PT J
AU Zhang, R
   Lao, L
   Ren, K
   Berman, BM
AF Zhang, Ruixin
   Lao, Lixing
   Ren, Ke
   Berman, Brian M
TI Mechanisms of acupuncture-electroacupuncture on persistent pain.
SO Anesthesiology
LA English
DT Review
AB In the last decade, preclinical investigations of electroacupuncture mechanisms 
   on persistent tissue injury (inflammatory), nerve injury (neuropathic), cancer, 
   and visceral pain have increased. These studies show that electroacupuncture 
   activates the nervous system differently in health than in pain conditions, 
   alleviates both sensory and affective inflammatory pain, and inhibits 
   inflammatory and neuropathic pain more effectively at 2 to 10 Hz than at 100 Hz. 
   Electroacupuncture blocks pain by activating a variety of bioactive chemicals 
   through peripheral, spinal, and supraspinal mechanisms. These include opioids, 
   which desensitize peripheral nociceptors and reduce proinflammatory cytokines 
   peripherally and in the spinal cord, and serotonin and norepinephrine, which 
   decrease spinal N-methyl-D-aspartate receptor subunit GluN1 phosphorylation. 
   Additional studies suggest that electroacupuncture, when combined with low 
   dosages of conventional analgesics, provides effective pain management which can 
   forestall the side effects of often-debilitating pharmaceuticals.
C1 From the Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland (R.Z., L.L., and B.M.B.)
   and Department of Neuraland Pain Sciences, Dental School, University of Maryland, Baltimore, Maryland(K.R.).
NR 0
TC 0
SN 1528-117
EI 0003-302
J9 Anesthesiology
PD DEC 11
PY 2013
VL 120
IS 2
BP 482
EP 503
DI 10.1097/ALN.0000000000000101 
PG 21
WC Acupuncture Points; Acupuncture Therapy; methods; Animals; Chronic Pain; etiology; Disease Models, Animal; Electroacupuncture; methods; Humans; Inflammation; complications; Neoplasms; complications; Neuralgia; drug therapy; Sensation; Spinal Cord; physiopathology; Visceral Pain; drug therapy
UT PubMed:24322588
PM 24322588
DA 2013-12-11
ER

PT J
AU Epstein, AS
   Liou, KT
   Romero, SAD
   Baser, RE
   Wong, G
   Xiao, H
   Mo, Z
   Walker, D
   MacLeod, J
   Li, Q
   Barton-Burke, M
   Deng, GE
   Panageas, KS
   Farrar, JT
   Mao, JJ
AF Epstein, Andrew S
   Liou, Kevin T
   Romero, Sally A D
   Baser, Raymond E
   Wong, Greta
   Xiao, Han
   Mo, Zunli
   Walker, Desiree
   MacLeod, Jodi
   Li, Qing
   Barton-Burke, Margaret
   Deng, Gary E
   Panageas, Katherine S
   Farrar, John T
   Mao, Jun J
TI Acupuncture vs Massage for Pain in Patients Living With Advanced Cancer: The 
SO JAMA network open
LA English
DT Journal Article
AB IMPORTANCE: Pain is challenging for patients with advanced cancer. While recent 
   guidelines recommend acupuncture and massage for cancer pain, their comparative 
   effectiveness is unknown. OBJECTIVE: To compare the effects of acupuncture and 
   massage on musculoskeletal pain among patients with advanced cancer. DESIGN, 
   SETTING, AND PARTICIPANTS: A multicenter pragmatic randomized clinical trial was 
   conducted at US cancer care centers consisting of a northeastern comprehensive 
   cancer center and a southeastern cancer institute from September 19, 2019, 
   through February 23, 2022. The principal investigator and study statisticians 
   were blinded to treatment assignments. The duration of follow-up was 26 weeks. 
   Intention-to-treat analyses were performed (linear mixed models). Participants 
   included patients with advanced cancer with moderate to severe pain and 
   clinician-estimated life expectancy of 6 months or more. Patient recruitment 
   strategy was multipronged (eg, patient database queries, mailings, referrals, 
   community outreach). Eligible patients had English or Spanish as their first 
   language, were older than 18 years, and had a Karnofsky score greater than or 
   equal to 60 (range, 0-100; higher scores indicating less functional impairment). 
   INTERVENTIONS: Weekly acupuncture or massage for 10 weeks with monthly booster 
   sessions up to 26 weeks. MAIN OUTCOMES AND MEASURES: The primary end point was 
   the change in worst pain intensity score from baseline to 26 weeks. The secondary 
   outcomes included fatigue, insomnia, and quality of life. The Brief Pain 
   Inventory (range, 0-10; higher numbers indicate worse pain intensity or 
   interference) was used to measure the primary outcome. The secondary outcomes 
   included fatigue, insomnia, and quality of life. RESULTS: A total of 298 
   participants were enrolled (mean [SD] age, 58.7 [14.1] years, 200 [67.1%] were 
   women, 33 [11.1%] Black, 220 [74.1%] White, 46 [15.4%] Hispanic, and 78.5% with 
   solid tumors). The mean (SD) baseline worst pain score was 6.9 (1.5). During 26 
   weeks, acupuncture reduced the worst pain score, with a mean change of -2.53 (95% 
   CI, -2.92 to -2.15) points, and massage reduced the Brief Pain Inventory worst 
   pain score, with a mean change of -3.01 (95% CI, -3.38 to -2.63) points; the 
   between-group difference was not significant (-0.48; 95% CI, -0.98 to 0.03; 
   P = .07). Both treatments also improved fatigue, insomnia, and quality of life 
   without significant between-group differences. Adverse events were mild and 
   included bruising (6.5% of patients receiving acupuncture) and transient soreness 
   (15.1% patients receiving massage). CONCLUSIONS AND RELEVANCE: In this randomized 
   clinical trial among patients with advanced cancer, both acupuncture and massage 
   were associated with pain reduction and improved fatigue, insomnia, and quality 
   of life over 26 weeks; however, there was no significant different between the 
   treatments. More research is needed to evaluate how best to integrate these 
   approaches into pain treatment to optimize symptom management for the growing 
   population of people living with advanced cancer. TRIAL REGISTRATION: 
   ClinicalTrials.gov Identifier: NCT04095234.
C1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Cancer Patient Support Center, Baptist Health Miami Cancer Institute, Miami, Florida.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Office of Nursing Research, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
NR 0
TC 0
SN 2574-380
EI 
J9 JAMA Netw Open
PD NOV 14
PY 2023
VL 6
IS 11
BP e2342482
EP e2342482
DI 10.1001/jamanetworkopen.2023.42482 
PG 1
WC Female; Humans; Male; Middle Aged; Acupuncture Therapy; Fatigue; Massage; Musculoskeletal Pain; Neoplasms; complications; Quality of Life; Sleep Initiation and Maintenance Disorders; Adult; Aged
UT PubMed:37962891
PM 37962891
DA 2023-11-14
ER

PT J
AU Mao, JJ
   Liou, KT
   Baser, RE
   Bao, T
   Panageas, KS
   Romero, SAD
   Li, QS
   Gallagher, RM
   Kantoff, PW
AF Mao, Jun J
   Liou, Kevin T
   Baser, Raymond E
   Bao, Ting
   Panageas, Katherine S
   Romero, Sally A D
   Li, Q Susan
   Gallagher, Rollin M
   Kantoff, Philip W
TI Effectiveness of Electroacupuncture or Auricular Acupuncture vs Usual Care for 
SO JAMA oncology
LA English
DT Journal Article
AB IMPORTANCE: The opioid crisis creates challenges for cancer pain management. 
   Acupuncture confers clinical benefits for chronic nonmalignant pain, but its 
   effectiveness in cancer survivors remains uncertain. OBJECTIVE: To determine the 
   effectiveness of electroacupuncture or auricular acupuncture for chronic 
   musculoskeletal pain in cancer survivors. DESIGN, SETTING, AND PARTICIPANTS: The 
   Personalized Electroacupuncture vs Auricular Acupuncture Comparative 
   Effectiveness (PEACE) trial is a randomized clinical trial that was conducted 
   from March 2017 to October 2019 (follow-up completed April 2020) across an urban 
   academic cancer center and 5 suburban sites in New York and New Jersey. Study 
   statisticians were blinded to treatment assignments. The 360 adults included in 
   the study had a prior cancer diagnosis but no current evidence of disease, 
   reported musculoskeletal pain for at least 3 months, and self-reported pain 
   intensity on the Brief Pain Inventory (BPI) ranging from 0 (no pain) to 10 (worst 
   pain imaginable). INTERVENTIONS: Patients were randomized 2:2:1 to 
   electroacupuncture (n = 145), auricular acupuncture (n = 143), or usual care 
   (n = 72). Intervention groups received 10 weekly sessions of electroacupuncture 
   or auricular acupuncture. Ten acupuncture sessions were offered to the usual care 
   group from weeks 12 through 24. MAIN OUTCOMES AND MEASURES: The primary outcome 
   was change in average pain severity score on the BPI from baseline to week 12. 
   Using a gatekeeping multiple-comparison procedure, electroacupuncture and 
   auricular acupuncture were compared with usual care using a linear mixed model. 
   Noninferiority of auricular acupuncture to electroacupuncture was tested if both 
   interventions were superior to usual care. RESULTS: Among 360 cancer survivors 
   (mean [SD] age, 62.1 [12.7] years; mean [SD] baseline BPI score, 5.2 [1.7] 
   points; 251 [69.7%] women; and 88 [24.4%] non-White), 340 (94.4%) completed the 
   primary end point. Compared with usual care, electroacupuncture reduced pain 
   severity by 1.9 points (97.5% CI, 1.4-2.4 points; P < .001) and auricular 
   acupuncture reduced by 1.6 points (97.5% CI, 1.0-2.1 points; P < .001) from 
   baseline to week 12. Noninferiority of auricular acupuncture to 
   electroacupuncture was not demonstrated. Adverse events were mild; 15 of 143 
   (10.5%) patients receiving auricular acupuncture and 1 of 145 (0.7%) patients 
   receiving electroacupuncture discontinued treatments due to adverse events 
   (P < .001). CONCLUSIONS AND RELEVANCE: In this randomized clinical trial among 
   cancer survivors with chronic musculoskeletal pain, electroacupuncture and 
   auricular acupuncture produced greater pain reduction than usual care. However, 
   auricular acupuncture did not demonstrate noninferiority to electroacupuncture, 
   and patients receiving it had more adverse events. TRIAL REGISTRATION: 
   ClinicalTrials.gov Identifier: NCT02979574.
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Family Medicine and Public Health, University of California, San Diego School of Medicine, San Diego.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Center for Health Equity Research and Promotion, Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
NR 0
TC 0
SN 2374-244
EI 2374-243
J9 JAMA Oncol
PD MAR 19
PY 2021
VL 7
IS 5
BP 720
EP 727
DI 10.1001/jamaoncol.2021.0310 
PG 7
WC Acupuncture, Ear; Adult; Cancer Survivors; Chronic Pain; therapy; Electroacupuncture; adverse effects; Female; Humans; Middle Aged; Musculoskeletal Pain; etiology; Neoplasms; complications; Treatment Outcome
UT PubMed:33734288
PM 33734288
DA 2021-03-19
ER

PT J
AU Yang, J
   Wahner-Roedler, DL
   Zhou, X
   Johnson, LA
   Do, A
   Pachman, DR
   Chon, TY
   Salinas, M
   Millstine, D
   Bauer, BA
AF Yang, Juan
   Wahner-Roedler, Dietlind L
   Zhou, Xuan
   Johnson, Lesley A
   Do, Alex
   Pachman, Deirdre R
   Chon, Tony Y
   Salinas, Manisha
   Millstine, Denise
   Bauer, Brent A
TI Acupuncture for palliative cancer pain management: systematic review.
SO BMJ supportive & palliative care
LA English
DT Journal Article
DE cancer; pain; supportive care
AB BACKGROUND: Pain is one of the most common and problematic symptoms encountered 
   by patients with cancer. Due to the multifactorial aetiology, pain management of 
   these patients frequently requires multidisciplinary interventions including 
   conventional support and specialty palliative care. Acupuncture has been 
   identified as a possible adjunctive therapy for symptom management in cancer 
   pain, and there is currently no systematic review focused solely on the evidence 
   of acupuncture on cancer pain in palliative care. OBJECTIVE: To critically 
   analyse currently available publications regarding the use of acupuncture for 
   pain management among patients with cancer in palliative care settings. METHODS: 
   Multiple academic databases were searched from inception to 29 October 2020. 
   Randomised controlled trials involving acupuncture in palliative care for 
   treatment of cancer-related pain were synthesised. Data were extracted by two 
   independent reviewers, and methodological quality of each included study was 
   assessed using the Oxford Centre for Evidence-Based Medicine (OCEBM) 2011 Levels 
   of Evidence. RESULTS: Five studies (n=189) were included in this systematic 
   review. Results indicated a favourable effect of acupuncture on pain relief in 
   palliative care for patients with cancer. According to OCEBM 2011 Levels of 
   Evidence, they were level 2 in one case (20%), level 3 in two cases (40%) and 
   level 4 in the remaining (40%). Low-level evidence adversely affects the 
   reliability of findings. CONCLUSIONS: Acupuncture may be an effective and safe 
   treatment associated with pain reduction in the palliative care of patients with 
   cancer. Further high-quality, adequately powered studies are needed in the 
   future.
C1 Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
   Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
   Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, China.
   Department of Women's Health/Internal Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
   Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
   Center for Palliative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
   Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
   Division of Family Medicine, Mayo Clinic, Jacksonville, Florida, USA.
   Department of Women's Health/Internal Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
   Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA Bauer.Brent@mayo.edu.
NR 0
TC 0
SN 2045-436
EI 2045-435
J9 BMJ Support Palliat Care
PD JAN 15
PY 2021
VL 11
IS 3
BP 264
EP 270
DI 10.1136/bmjspcare-2020-002638 
PG 6
WC Acupuncture Therapy; Cancer Pain; therapy; Humans; Neoplasms; complications; Pain Management; Palliative Care; Reproducibility of Results
UT PubMed:33441387
PM 33441387
DA 2021-01-15
ER

PT J
AU Zhang, Y
   Wang, S
   Ma, X
   Yuan, Y
   Cheng, H
   Lin, L
   Tian, L
AF Zhang, Yueyue
   Wang, Shaotong
   Ma, Xiaomin
   Yuan, Yang
   Cheng, Hui
   Lin, Lu
   Tian, Li
TI Massage therapy can effectively relieve cancer pain: A meta-analysis.
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: To critically evaluate the effects of massage therapy on cancer pain. 
   METHODS: Nine Chinese and English databases (PubMed, Cochrane Library, Embase, 
   SCOPUS, Web of Science core, China Biomedical Literature Database, China National 
   Knowledge Infrastructure, Wanfang, and VIP) were systematically searched from the 
   inception of databases to November 2022 for randomized controlled trials. 
   According to Cochrane Collaboration, 2 reviewers independently assessed the risk 
   of bias and extracted data from the included studies. All analyses were performed 
   with Review Manager 5.4. RESULTS: Thirteen randomized controlled trials were 
   included in the meta-analysis, containing 1000 patients (498 in the massage 
   therapy group and 502 in the control group). Massage therapy could significantly 
   relieve cancer pain in patients (standardized mean difference = -1.16, 95% 
   confidence interval [-1.39, -0.93], P < .00001), especially those in the 
   perioperative period and those with hematological malignancies. Foot reflexology 
   and hand acupressure had a moderate effect on cancer pain relief, with hand 
   acupressure being more effective. Massage duration of 10 to 30 minutes and a 
   program length of ≥1 week had a better effect and could significantly relieve 
   pain. The occurrence of adverse events was reported in 4 of the 13 studies, all 
   of which were no adverse events. CONCLUSIONS: Massage therapy can be used as a 
   complementary alternative therapy to relieve cancer pain in patients with 
   hematological malignancies, breast cancer, and cancers of the digestive system. 
   It is suggested that chemotherapy patients use foot reflexology, and 
   perioperative period patients use hand acupressure. A massage duration of 10 to 
   30 minutes and a program length of ≥1 week is recommended to achieve better 
   effects.
C1 School of Nursing, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
   The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of 
   School of Nursing, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
   The First People's Hospital of Kunshan, Suzhou, People's Republic of China.
   School of Nursing, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
   School of Nursing, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
   School of Nursing, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
   The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of 
   School of Nursing, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
   The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of 
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JUL 7
PY 2023
VL 102
IS 27
BP e33939
EP e33939
DI 10.1097/MD.0000000000033939 
PG 1
WC Humans; Female; Cancer Pain; therapy; Massage; Complementary Therapies; Breast Neoplasms; Hematologic Neoplasms
UT PubMed:37417622
PM 37417622
DA 2023-07-07
ER

PT J
AU He, Y
   Guo, X
   May, BH
   Zhang, AL
   Liu, Y
   Lu, C
   Mao, JJ
   Xue, CC
   Zhang, H
AF He, Yihan
   Guo, Xinfeng
   May, Brian H
   Zhang, Anthony Lin
   Liu, Yihong
   Lu, Chuanjian
   Mao, Jun J
   Xue, Charlie Changli
   Zhang, Haibo
TI Clinical Evidence for Association of Acupuncture and Acupressure With Improved 
SO JAMA oncology
LA English
DT Journal Article
AB IMPORTANCE: Research into acupuncture and acupressure and their application for 
   cancer pain has been growing, but the findings have been inconsistent. OBJECTIVE: 
   To evaluate the existing randomized clinical trials (RCTs) for evidence of the 
   association of acupuncture and acupressure with reduction in cancer pain. DATA 
   SOURCES: Three English-language databases (PubMed, Embase, and CINAHL) and 4 
   Chinese-language biomedical databases (Chinese Biomedical Literature Database, 
   VIP Database for Chinese Technical Periodicals, China National Knowledge 
   Infrastructure, and Wanfang) were searched for RCTs published from database 
   inception through March 31, 2019. STUDY SELECTION: Randomized clinical trials 
   that compared acupuncture and acupressure with a sham control, analgesic therapy, 
   or usual care for managing cancer pain were included. DATA EXTRACTION AND 
   SYNTHESIS: Data were screened and extracted independently using predesigned 
   forms. The quality of RCTs was appraised with the Cochrane Collaboration risk of 
   bias tool. Random-effects modeling was used to calculate the effect sizes of 
   included RCTs. The quality of evidence was evaluated with the Grading of 
   Recommendations Assessment, Development and Evaluation approach. MAIN OUTCOMES 
   AND MEASURES: The primary outcome was pain intensity measured by the Brief Pain 
   Inventory, Numerical Rating Scale, Visual Analog Scale, or Verbal Rating Scale. 
   RESULTS: A total of 17 RCTs (with 1111 patients) were included in the systematic 
   review, and data from 14 RCTs (with 920 patients) were used in the meta-analysis. 
   Seven sham-controlled RCTs (35%) were notable for their high quality, being 
   judged to have a low risk of bias for all of their domains, and showed that real 
   (compared with sham) acupuncture was associated with reduced pain intensity (mean 
   difference [MD], -1.38 points; 95% CI, -2.13 to -0.64 points; I2 = 81%). A 
   favorable association was also seen when acupuncture and acupressure were 
   combined with analgesic therapy in 6 RCTs for reducing pain intensity (MD, -1.44 
   points; 95% CI, -1.98 to -0.89; I2 = 92%) and in 2 RCTs for reducing opioid dose 
   (MD, -30.00 mg morphine equivalent daily dose; 95% CI, -37.5 mg to -22.5 mg). The 
   evidence grade was moderate because of the substantial heterogeneity among 
   studies. CONCLUSIONS AND RELEVANCE: This systematic review and meta-analysis 
   found that acupuncture and/or acupressure was significantly associated with 
   reduced cancer pain and decreased use of analgesics, although the evidence level 
   was moderate. This finding suggests that more rigorous trials are needed to 
   identify the association of acupuncture and acupressure with specific types of 
   cancer pain and to integrate such evidence into clinical care to reduce opioid 
   use.
C1 Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy ofChinese Medical Sciences, Guangzhou, Guangdong Province, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy ofChinese Medical Sciences, Guangzhou, Guangdong Province, China.
   China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
   China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
   Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy ofChinese Medical Sciences, Guangzhou, Guangdong Province, China.
   Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy ofChinese Medical Sciences, Guangzhou, Guangdong Province, China.
   Integrative Medicine Department, Memorial Sloan Kettering Cancer Center, New York, New York.
   Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy ofChinese Medical Sciences, Guangzhou, Guangdong Province, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy ofChinese Medical Sciences, Guangzhou, Guangdong Province, China.
NR 0
TC 0
SN 2374-244
EI 2374-243
J9 JAMA Oncol
PD DEC 20
PY 2019
VL 6
IS 2
BP 271
EP 278
DI 10.1001/jamaoncol.2019.5233 
PG 7
WC Acupressure; adverse effects; Acupuncture Therapy; adverse effects; Cancer Pain; therapy; Humans; Randomized Controlled Trials as Topic
UT PubMed:31855257
PM 31855257
DA 2019-12-20
ER

PT J
AU Scarborough, BM
   Smith, CB
AF Scarborough, Bethann M
   Smith, Cardinale B
TI Optimal pain management for patients with cancer in the modern era.
SO CA: a cancer journal for clinicians
LA English
DT Review
DE addiction; adjuvant; cancer; opioid; pain assessment; pain management
AB Pain is a common symptom among patients with cancer. Adequate pain assessment and 
   management are critical to improve the quality of life and health outcomes in 
   this population. In this review, the authors provide a framework for safely and 
   effectively managing cancer-related pain by summarizing the evidence for the 
   importance of controlling pain, the barriers to adequate pain management, 
   strategies to assess and manage cancer-related pain, how to manage pain in 
   patients at risk of substance use disorder, and considerations when managing pain 
   in a survivorship population. CA Cancer J Clin 2018;68:182-196. © 2018 American 
   Cancer Society.
C1 Assistant Professor, Brookdale Department of Geriatrics and Palliative Care, Icahn School of Medicine at Mount Sinai, New York, NY.
   Associate Professor of Medicine, Division of Hematology and Medical Oncology, Brookdale Department of Geriatrics and Palliative Care, Icahn School of Medicineat Mount Sinai, New York, NY.
   Director of Quality for Cancer Services, Mount Sinai Health System, Tisch Cancer 
NR 0
TC 0
SN 1542-486
EI 0007-923
J9 CA Cancer J Clin
PD APR 1
PY 2018
VL 68
IS 3
BP 182
EP 196
DI 10.3322/caac.21453 
PG 14
WC Acupuncture Therapy; Analgesics, Non-Narcotic; therapeutic use; Analgesics, Opioid; therapeutic use; Anticonvulsants; therapeutic use; Antidepressive Agents; therapeutic use; Cancer Pain; diagnosis; Delayed-Action Preparations; Healthcare Disparities; Humans; Injections, Epidural; Injections, Spinal; Medical Marijuana; therapeutic use; Mindfulness; Nerve Block; Pain Measurement; Prescription Drug Misuse; Quality of Life; Radiotherapy; Substance-Related Disorders; diagnosis
UT PubMed:29603142
PM 29603142
DA 2018-04-01
ER

PT J
AU Zhang, XW
   Hou, WB
   Pu, FL
   Wang, XF
   Wang, YR
   Yang, M
   Cheng, K
   Wang, Y
   Robinson, N
   Liu, JP
AF Zhang, Xiao-Wen
   Hou, Wen-Bin
   Pu, Feng-Lan
   Wang, Xue-Feng
   Wang, Yi-Ran
   Yang, Ming
   Cheng, Ke
   Wang, Yuyi
   Robinson, Nicola
   Liu, Jian-Ping
TI Acupuncture for cancer-related conditions: An overview of systematic reviews.
SO Phytomedicine : international journal of phytotherapy and phytopharmacology
LA English
DT Review
DE Acupuncture; Cancer-related conditions; Overview; Randomized controlled trials; Systematic reviews
AB BACKGROUND: Acupuncture is commonly used for cancer-related conditions worldwide, 
   and evidence is increasing year on year. There is a need to summarize the 
   evidence of acupuncture for cancer-related conditions comprehensively and 
   critically. OBJECTIVE: To evaluate and summarize the systematic reviews (SRs) 
   that assess the effects and safety of acupuncture for cancer-related conditions, 
   and to inform clinical practice and future studies. METHODS: A comprehensive 
   search was conducted on Pubmed, Embase, the Cochrane Library, Web of Science, 
   CNKI, VIP, Sinomed, and Wanfang from their inception to October 16, 2021. SRs of 
   randomized controlled trials (RCTs) on acupuncture for cancer-related conditions 
   were to be included. Two reviewers screened the eligible articles, and four 
   reviewers in pair extracted data and assessed the methodological quality/risk of 
   bias of all included reviews by AMSTAR 2 and ROBIS tools. The overlap of primary 
   studies was measured by calculating corrected covered areas. Data from the 
   included reviews were synthesized with a summary of meta-analysis or narrative 
   description. RESULTS: Fifty-one SRs of RCTs on acupuncture for cancer-related 
   conditions were included and synthesized. The methodological quality of SRs 
   included 1 "high", 5 "low" and 45 "very low" by AMSTAR 2. Sixteen SRs assessed as 
   low risk of bias (31.37%), and 35 SRs had high risk of bias (68.63%) by ROBIS. 
   Acupuncture showed effective on systemic conditions in relation to different 
   cancers, including cancer-related pain (17 SRs, 80 RCTs), fatigue (7 SRs, 18 
   RCTs), insomnia (4 SRs, 10 RCTs), quality of life (2 SRs, 15 RCTs); conditions in 
   relation to chemo-radiotherapy, including nausea and vomiting (3 SRs, 36 RCTs) 
   and bone marrow suppression (2 SRs, 21 RCTs); and conditions in relation to 
   specific cancers, including breast cancer-related menopause (3 SRs, 6 RCTs), hot 
   flashes (12 SRs, 13 RCTs), arthralgia (5 SRs, 10 RCTs), and nasopharyngeal 
   cancer-related dysphagia (1 SRs, 7 RCTs). Acupuncture appeared to have benefit 
   for patients with lymphoedema (3 SRs, 3 RCTs), gastrointestinal function (5 SRs, 
   27 RCTs), and xerostomia (4 SRs, 7 RCTs). Limited evidence showed inconsistent 
   results on acupuncture for chemotherapy-induced peripheral neuropathy (3 SRs, 6 
   RCTs), depression and anxiety (3 SRs, 9 RCTs). Acupuncture was regarded as a safe 
   therapy for cancer patients as no severe adverse events related were reported. 
   CONCLUSION: Evidence from SRs showed that acupuncture is beneficial to cancer 
   survivors with cancer-related pain, fatigue, insomnia, improved quality of life, 
   nausea and vomiting, bone marrow suppression, menopausal symptoms, arthralgia, 
   and dysphagia, and may also be potential for lymphoedema, gastrointestinal 
   function, and xerostomia. For neuropathy, depression and anxiety, acupuncture 
   should be used as an option based on individual conditions. Acupuncture is 
   relatively safe without serious adverse events. More well-designed clinical 
   trials of acupuncture are recommended on cancer-related depression and anxiety, 
   arthralgia, xerostomia, gastrointestinal dysfunction and dysphagia.
C1 Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
   Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
   Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
   School of Humanities, Beijing University of Chinese Medicine, Beijing 100029, China.
   School of Humanities, Beijing University of Chinese Medicine, Beijing 100029, China.
   The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
   Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400011, China.
   Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
   Institute of Health and Social Care, LondonSouth Bank University, London, UK.
   Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
   The National Research Center in Complementaryand Alternative Medicine (NAFKAM), Department of Community Medicine, Faculty ofHealth Science, UiT The Arctic University of Tromsø, Tromsø 9037, Norway.
EM Liujp@bucm.edu.cn
NR 0
TC 0
SN 1618-095
EI 
J9 Phytomedicine
PD SEP 14
PY 2022
VL 106
IS 
BP 154430
EP 154430
DI 10.1016/j.phymed.2022.154430 
PG 0
WC Acupuncture Therapy; methods; Antineoplastic Agents; Arthralgia; etiology; Cancer Pain; Deglutition Disorders; etiology; Fatigue; Female; Humans; Lymphedema; etiology; Nausea; etiology; Neoplasms; etiology; Sleep Initiation and Maintenance Disorders; Systematic Reviews as Topic; Vomiting; etiology; Xerostomia; etiology
UT PubMed:36099656
PM 36099656
DA 2022-09-14
ER

PT J
AU Brozović, G
   Lesar, N
   Janev, D
   Bošnjak, T
   Muhaxhiri, B
AF Brozović, Gordana
   Lesar, Nikola
   Janev, Dimitar
   Bošnjak, Tomislav
   Muhaxhiri, Burim
TI CANCER PAIN AND THERAPY.
SO Acta clinica Croatica
LA English
DT Review
DE adjuvant drugs; cancer pain; integrative medicine; non-opioids; opioids; regional nerve block
AB Cancer pain is not a homogenous and clearly understood pathological process. The 
   best treatment is a combination of drug and non-drug measures. Pain is divided 
   into visceral, bone or neuropathic pain and has characteristics of continuous or 
   intermittent pain. Cancer bone pain therapy remains centered on strong opioid, 
   radiotherapy and bisphosphonates. Invasive procedures are aimed to improve 
   neurological function, ambulation and pain relief. Solid tumors often demand 
   surgery. Treatment of acute postoperative pain is crucial for the prevention of 
   chronic pain. Chemotherapy and radiation sometimes also cause pain. The 
   management of cancer pain has improved because of rapid diagnosis and treatment, 
   understanding of analgesics and the cooperation of patients and their family. The 
   presence of special pain centers in hospitals also raise standard of cancer pain 
   management. Drug therapy with non-opioid, opioid and adjuvant drugs is the base 
   of such management. The side effects must be monitored and timely treated. 
   Methods of regional nerve blockade in pain control are numerous. Placement of 
   epidural, intrathecal and subcutaneous catheters, conductive nerve blocks with 
   continuous delivery of mixed local anesthetics are very successful for selected 
   patients. Conventional physical therapy involving lymphatic drainage is useful. 
   Acupuncture, psychotherapy and similar methods are also applicable.
C1 Division of Anaesthesiology, Reanimatology and Intensive Care Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center,Zagreb, Croatia.
   Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of 
   Division of Anaesthesiology, Reanimatology and Intensive Care Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center,Zagreb, Croatia.
   Division of Anaesthesiology, Reanimatology and Intensive Care Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center,Zagreb, Croatia.
   Division of Anaesthesiology, Reanimatology and Intensive Care Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center,Zagreb, Croatia.
   Division of Anaesthesiology, Reanimatology and Intensive Care Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center,Zagreb, Croatia.
NR 0
TC 0
SN 1333-945
EI 0353-946
J9 Acta Clin Croat
PD FEB 25
PY 2023
VL 61
IS Suppl 2
BP 103
EP 108
DI 10.20471/acc.2022.61.s2.13 
PG 5
WC Humans; Cancer Pain; drug therapy; Pain Management; Analgesics, Opioid; Pain, Postoperative; drug therapy; Analgesics; therapeutic use; Chronic Pain; drug therapy; Anesthetics, Local; Neoplasms
UT PubMed:36824638
PM 36824638
DA 2023-02-25
ER

PT J
AU Lu, S
   Wang, B
   Wang, J
   Guo, Y
   Li, S
   Zhao, S
   Yang, Y
   Feng, Y
   Xu, Z
AF Lu, Shanshan
   Wang, Bin
   Wang, Jiaqi
   Guo, Yi
   Li, Shanshan
   Zhao, Suhong
   Yang, Yuanzhen
   Feng, Yiting
   Xu, Zhifang
TI Moxibustion for the Treatment of Cancer and its Complications: Efficacies and 
SO Integrative cancer therapies
LA English
DT Review
DE cancer; chemotherapy; complications of cancer; moxibustion; side-effect
AB Cancer treatment remains a significant challenge for the medical community, and 
   improved therapies are necessary to treat cancer and its associated 
   complications. Current anticancer therapies often have significant side effects, 
   underscoring the need for new treatment options. Moxibustion is a representative 
   external therapy used in traditional Chinese medicine. This review examines 
   clinical studies demonstrating moxibustion's ability to improve the efficacy of 
   radiotherapy and chemotherapy and control tumor progression. Moxibustion can 
   prevent and treat various complications of cancer, including cancer-related or 
   therapy-induced gastrointestinal symptoms, myelosuppression, fatigue, pain, and 
   postoperative lymphedema. has also been shown to enhance the quality of life for 
   cancer patients. However, very few studies have investigated the underlying 
   mechanisms for these effects, a topic that requires systematic elucidation. 
   Evidence has shown that moxibustion alone or combined with chemotherapy can 
   improve survival and inhibit tumor growth in cancer-bearing animal models. The 
   anticancer effect of moxibustion is associated with alleviating the tumor 
   immunosuppressive and vascular microenvironments. Additionally, the therapeutic 
   effects of moxibustion may originate from the heat and radiation produced during 
   the combustion process on acupoints or lesions. This evidence provides a 
   scientific basis for the clinical application of moxibustion in anticancer 
   treatment and reducing the side effects of cancer therapies and helps promote the 
   precise application of moxibustion in cancer treatment.
C1 Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, P. R. China.
   Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.
   Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, P. R. China.
   Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.
   Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.
   Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.
   Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.
   Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.
   Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD SEP 25
PY 2023
VL 22
IS 
BP 15347354231198089
EP 15347354231198089
DI 10.1177/15347354231198089 
PG 1
WC Humans; Moxibustion; adverse effects; Quality of Life; Neoplasms; drug therapy; Fatigue; therapy; Medicine, Chinese Traditional; Tumor Microenvironment
UT PubMed:37746720
PM 37746720
DA 2023-09-25
ER

PT J
AU Faria, M
   Teixeira, M
   Pinto, MJ
   Sargento, P
AF Faria, Miguel
   Teixeira, Mónica
   Pinto, Maria João
   Sargento, Paulo
TI Efficacy of acupuncture on cancer pain: A systematic review and meta-analysis.
SO Journal of integrative medicine
LA English
DT Journal Article
DE Acupuncture; Cancer pain; Meta-analysis; Systematic review
AB BACKGROUND: Pain associated with cancer is one of the greatest causes of reduced 
   quality of life in patients. Acupuncture is one of the treatments used to address 
   this issue, with the great advantage of having little or no side effects, 
   especially when compared with pharmacological pain-killers. OBJECTIVE: The aim of 
   this systematic review and meta-analysis was to evaluate the current evidence 
   regarding the efficacy of acupuncture for cancer pain. SEARCH STRATEGY: Six 
   electronic databases (PubMed, EBSCO, Cochrane Library, Scielo, b-On and Scopus) 
   were searched for relevant articles about pain relief in cancer patients from 
   their beginning until 2022 using MeSH terms such as "acupuncture," 
   "electroacupuncture," "ear acupuncture," "acupuncture analgesia," ''oncological 
   pain," and "cancer pain." INCLUSION CRITERIA: Studies included were randomized 
   controlled trials (RCTs) where acupuncture was compared with no treatment, 
   placebo acupuncture or usual care. DATA EXTRACTION AND ANALYSIS: Three 
   independent reviewers participated in data extraction and evaluation of risk of 
   bias, and a meta-analysis was conducted. The primary outcome was pain intensity, 
   measured with the visual analog scale, numeric rating scale, or brief pain 
   inventory. Secondary outcomes also assessed were quality of life, functionality, 
   xerostomia, pain interference, and analgesic consumption. Results were expressed 
   as standardized mean difference (SMD) with 95% confidence interval (CI). RESULTS: 
   Sixteen RCTs with a total of 1124 participants were included in the 
   meta-analysis, with the majority of the studies presenting a low or unclear risk 
   of bias. Acupuncture was more effective in reducing pain than no treatment 
   (SMD = -0.90, 95 % CI [-1.68, -0.12]), sham acupuncture (SMD = -1.10, 95 % CI 
   [-1.59, -0.61]) or usual care (SMD = -1.16, 95 % CI [-1.38, -0.93]). CONCLUSION: 
   The results of this study suggest that acupuncture may be an effective 
   intervention to reduce pain associated with cancer. Despite some limitations due 
   to the low quality and small sample size of some included studies, as well as the 
   different types and stages of cancer, acupuncture might provide an effective and 
   safe treatment to reduce cancer pain. Please cite this article as: Faria M, 
   Teixeira M, Pinto MJ, Sargento P. Efficacy of acupuncture on cancer pain: A 
   systematic review and meta-analysis. J Integr Med. 2024; 22(3): 235-244.
C1 Núcleo de Investigação em Ciências e Tecnologias da Saúde, Instituto Politécnico da Lusofonia, 1950-396 Lisboa, Portugal
   Clínica São João de Deus, 1700-048Lisboa, Portugal. 
   Núcleo de Investigação em Ciências e Tecnologias da Saúde, Instituto Politécnico da Lusofonia, 1950-396 Lisboa, Portugal
   REQUIMTE/LAQV (Rede de Química eTecnologia/Laboratório Associado para a Química Verde), Instituto Superior deEngenharia, Instituto Politécnico do Porto, 4051-401 Porto, Portugal.
   Hospital SOERAD, 2560-312 Torres Vedras, Portugal.
   Núcleo de Investigação em Ciências e Tecnologias da Saúde, Instituto Politécnico da Lusofonia, 1950-396 Lisboa, Portugal
   Centro de Estudos Avançados em Direito"Francisco Suarez", 1749-024 Lisboa, Portugal.
EM miguel.faria@ipluso.pt
NR 0
TC 0
SN 
EI 2095-496
J9 J Integr Med
PD MAR 17
PY 2024
VL 22
IS 3
BP 235
EP 244
DI 10.1016/j.joim.2024.03.002 
PG 9
WC Humans; Acupuncture Therapy; adverse effects; Cancer Pain; diagnosis; Neoplasms; complications; Pain Management; adverse effects; Pain Measurement; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:38493063
PM 38493063
DA 2024-03-17
ER

PT J
AU Zhang, J
   Qin, Z
   So, TH
   Chang, TY
   Yang, S
   Chen, H
   Yeung, WF
   Chung, KF
   Chan, PY
   Huang, Y
   Xu, S
   Chiang, CY
   Lao, L
   Zhang, ZJ
AF Zhang, Jialing
   Qin, Zongshi
   So, Tsz Him
   Chang, Tien Yee
   Yang, Sichang
   Chen, Haiyong
   Yeung, Wing Fai
   Chung, Ka Fai
   Chan, Pui Yan
   Huang, Yong
   Xu, Shifen
   Chiang, Chun Yuan
   Lao, Lixing
   Zhang, Zhang-Jin
TI Acupuncture for chemotherapy-associated insomnia in breast cancer patients: an 
SO Breast cancer research : BCR
LA English
DT Journal Article
DE Acupuncture; Breast cancer; Cessation rate of sleeping medications; Chemotherapy-associated insomnia
AB BACKGROUND: Insomnia is a highly prevalent symptom occurred during and 
   post-chemotherapy. Acupuncture may have beneficial effects in the management of 
   chemotherapy-associated insomnia. This study was conducted to determine the 
   efficacy and safety of acupuncture in improving chemotherapy-associated insomnia 
   in breast cancer patients. METHODS: This assessor-participant blinded, 
   randomized, sham-controlled trial was conducted from November 2019 to January 
   2022 (follow-up completed July 2022). Participants were referred by oncologists 
   from two Hong Kong hospitals. Assessments and interventions were conducted at the 
   outpatient clinic of School of Chinese Medicine, the University of Hong Kong. The 
   138 breast cancer patients with chemotherapy-associated insomnia were randomly 
   assigned to receive either 15 sessions of active acupuncture regimen by combining 
   needling into body acupoints and acupressure on auricular acupoints or sham 
   acupuncture control (69 each) for 18 weeks, followed by 24 weeks of follow-up. 
   The primary outcome was measured using Insomnia Severity Index (ISI). Secondary 
   outcomes included the Pittsburgh Sleep Quality Index, Actiwatch and sleep diary 
   for sleep parameters, depression and anxiety, fatigue and pain, and quality of 
   life. RESULTS: There were 87.7% (121/138) participants who completed the primary 
   endpoint (week-6). The active acupuncture regimen was not superior to the sham 
   control in reducing ISI score from baseline to 6 weeks (mean difference: - 0.4, 
   95% CI - 1.8-1.1; P = 0.609), but produced short-term treatment and long-term 
   follow-up better outcomes in improving sleep onset latency, total sleep time, 
   sleep efficiency, anxiety, depression, and quality of life. Participants of the 
   active acupuncture group had a pronouncedly higher cessation rate of sleeping 
   medications than the sham control (56.5% vs. 14.3%, P = 0.011). All 
   treatment-related adverse events were mild. No participants discontinued 
   treatments due to adverse events. CONCLUSION: The active acupuncture regimen 
   could be considered as an effective option for the management of 
   chemotherapy-associated insomnia. It also could serve as a tapering approach to 
   reduce and even replace the use of sleeping medications in breast cancer 
   patients. Trial registration Clinicaltrials.gov : NCT04144309. Registered 30 
   October 2019.
C1 School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
   School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong 
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
   Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
   Comprehensive Oncology Centre, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, China.
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
   School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
   Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong, China.
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
   School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
   Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China.
   Hong Kong Institute of Cell & Molecular Medicine and Digital Centre of State-Key-Laboratory on Quality Appraisal of TCM, Hong Kong, China.
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China. llao@vuim.edu.
   Virginia University of Integrative Medicine, Fairfax, VA, 22031, USA. 
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China. zhangzj@hku.hk.
   Department of Chinese Medicine, The University of Hong Kong Shenzhen Hospital 
NR 0
TC 0
SN 1465-542
EI 1465-541
J9 Breast Cancer Res
PD APR 27
PY 2023
VL 25
IS 1
BP 49
EP 49
DI 10.1186/s13058-023-01645-0 
PG 0
WC Humans; Female; Sleep Initiation and Maintenance Disorders; chemically induced; Breast Neoplasms; complications; Quality of Life; Acupuncture Therapy; adverse effects; Sleep; Treatment Outcome
UT PubMed:37101228
PM 37101228
DA 2023-04-27
ER

PT J
AU Liao, HY
   Satyanarayanan, SK
   Lin, YW
   Su, KP
AF Liao, Hsien-Yin
   Satyanarayanan, Senthil Kumaran
   Lin, Yi-Wen
   Su, Kuan-Pin
TI Clinical efficacy and immune effects of acupuncture in patients with comorbid 
SO Brain, behavior, and immunity
LA English
DT Journal Article
DE Acupuncture; Biomarkers; Chronic pain; Comorbidity; Inflammatory cytokines; Major depression disorder
AB BACKGROUND: Depression and pain are highly comorbid and share biological 
   mechanisms. Acupuncture is commonly used to manage both pain and depression, but 
   the choice of acupoints for specific disorders differs. This study aimed to 
   investigate whether specific acupuncture intervention on pain- and 
   depression-acupoints would have specific efficacy and immune effects in patients 
   with comorbid chronic pain and major depressive disorder (MDD). METHODS: We 
   performed a subject- and assessor-blinded, crossover, and randomized controlled 
   clinical trial of depression- and pain-specific acupuncture intervention and 
   measured clinical responses and proinflammatory cytokines in patients with 
   comorbid chronic pain and MDD. Specific acupoints for pain and depression were 
   used in random order with a washout interval. Forty-seven patients were enrolled 
   and randomly assigned to two groups: (1) the depression-pain group (23 patients 
   who were treated with depression-specific acupoints and then the pain-specific 
   acupoints after the washout) and (2) pain-depression group (24 patients with the 
   reverse order). RESULTS: The pain-specific acupoints for pain did not reduce 
   Brief Pain Inventory scores to a significantly greater degree (-0.97 ± 1.69) than 
   the depression-specific acupoints (-0.28 ± 1.88); likewise, the 
   depression-specific acupoints did not significantly ameliorate Hamilton 
   Depression Rating Scale (-4.59 ± 6.02) than the pain-specific acupoints 
   (-6.69 ± 6.61). The pain-specific acupoints improved Beck Depression 
   Inventory-Second Edition (-6.74 ± 9.76) even better than the depression-specific 
   acupoints (-1.92 ± 10.74). The depression-specific acupoints did not 
   significantly decrease the depression-related interleukin (IL)-6 level 
   (-1.24 ± 6.67) than the pain-specific acupoints (-0.60 ± 4.36). The changed 
   levels of IL-1β, tumor necrosis factor (TNF)-α between the depression-specific 
   acupoints (-37.41 ± 194.49; -12.53 ± 54.68) and the pain-specific acupoints 
   (-15.46 ± 87.56; -7.28 ± 27.86) could not reach significantly different, too. 
   CONCLUSION: This study rejected our hypothesis that the pain-specific acupoints 
   might produce superior analgesic effects than the depression-specific acupoints 
   and vice versa. The cytokine results might imply that pain and depression share 
   common biological mechanisms. (trial registration: https://www. CLINICALTRIALS: 
   gov: NCT03328819).
C1 School of Post-Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
   Department of Acupuncture, ChinaMedical University Hospital, Taichung 40402, Taiwan.
   Mind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.
   Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
   Chinese Medicine Research Center,China Medical University, Taichung 40402, Taiwan. 
   Mind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan
   College of Medicine, China Medical University, Taichung,Taiwan
   Depression Center, An-Nan Hospital, China Medical University, Tainan,Taiwan. 
EM cobolsu@gmail.com
NR 0
TC 0
SN 1090-213
EI 
J9 Brain Behav Immun
PD MAR 23
PY 2023
VL 110
IS 
BP 339
EP 347
DI 10.1016/j.bbi.2023.03.016 
PG 8
WC Humans; Depressive Disorder, Major; complications; Cross-Over Studies; Chronic Pain; therapy; Depression; Acupuncture Therapy; adverse effects; Treatment Outcome
UT PubMed:36948325
PM 36948325
DA 2023-03-23
ER

PT J
AU de, Sousa TR
   Mattos, S
   Marcon, G
   Furtado, T
   Duarte, da Silva M
AF de Sousa, Tatiane Regina
   Mattos, Suzana
   Marcon, Giovanna
   Furtado, Thayná
   Duarte da Silva, Morgana
TI Acupuncture techniques and acupoints used in individuals under chemotherapy or 
SO Journal of clinical nursing
LA English
DT Journal Article
DE acupoints; acupuncture; cancer; pain
AB AIMS AND OBJECTIVES: To describe the main acupuncture techniques and parameters 
   that have been used in the most varied symptoms of different types of cancer. 
   BACKGROUND: Clinical evidence about the potential effectiveness of acupuncture 
   and related therapies to control signs and symptoms associated with cancer or its 
   treatment has been in several studies. Currently, there is already evidence of 
   the use of acupuncture for the treatment of nausea and vomiting, fatigue, dry 
   mouth, anxiety, depression, insomnia and pain. However, many studies lack firm 
   rights or reproducible guidelines for treatment. DESIGN: This study performs a 
   systematic review of clinical trials related to the topic, based on the PRISMA 
   protocol. Thus, a search was carried out in the Scopus, Pubmed and Web of Science 
   databases, covering studies since January 2007. METHODS: Structured and organised 
   according to PICO standards, using keywords ("cancer" OR "malignant tumour" OR 
   "chemotherapy" OR "radiotherapy") AND ("acupuncture" OR "electroacupuncture") AND 
   ("pain" OR "nausea" OR "vomit" OR "fatigue" OR "xerostomia" OR "insomnia" OR 
   "depression" OR "neuropathy"). RESULTS: After the selection and evaluation phase, 
   23 studies were included and analysed. CONCLUSION: Based on this analysis, it is 
   concluded that acupuncture is safe and there is evidence of the reduction of 
   gastrointestinal symptoms, chemotherapy-induced peripheral neuropathy, pain, dry 
   mouth, fatigue, insomnia, and improvement of cognitive capacity. RELEVANCE TO 
   CLINICAL PRACTICE: Acupuncture treatments could act by minimising the side 
   effects of conventional treatments and reducing symptoms induced by tumours. NO 
   PATIENT OR PUBLIC CONTRIBUTION: The patients had no direct involvement with the 
   study in question.
C1 Program of Post-graduation in Neuroscience, Federal University of Santa Catarina, Florianópolis, Brazil.
   Laboratory of Neurobiology of Pain and Inflammation (LANDI), Department of 
   Department of physiotherapy, Estacio de Santa Catarina University Center, São José, Brazil.
   Department of physiotherapy, Estacio de Santa Catarina University Center, São José, Brazil.
   Department of physiotherapy, Estacio de Santa Catarina University Center, São José, Brazil.
   Program of Post-graduation in Neuroscience, Federal University of Santa Catarina, Florianópolis, Brazil.
   Laboratory of Neurobiology of Pain and Inflammation (LANDI), Department of 
NR 0
TC 0
SN 1365-270
EI 
J9 J Clin Nurs
PD JUN 29
PY 2023
VL 32
IS 19-20
BP 6917
EP 6933
DI 10.1111/jocn.16812 
PG 16
WC Humans; Acupuncture Points; Acupuncture Therapy; adverse effects; Electroacupuncture; adverse effects; Neoplasms; radiotherapy; Nausea; chemically induced; Xerostomia; etiology; Pain; etiology
UT PubMed:37382085
PM 37382085
DA 2023-06-29
ER

PT J
AU Hershman, DL
   Unger, JM
   Greenlee, H
   Capodice, JL
   Lew, DL
   Darke, AK
   Kengla, AT
   Melnik, MK
   Jorgensen, CW
   Kreisle, WH
   Minasian, LM
   Fisch, MJ
   Henry, NL
   Crew, KD
AF Hershman, Dawn L
   Unger, Joseph M
   Greenlee, Heather
   Capodice, Jillian L
   Lew, Danika L
   Darke, Amy K
   Kengla, Alice T
   Melnik, Marianne K
   Jorgensen, Carla W
   Kreisle, William H
   Minasian, Lori M
   Fisch, Michael J
   Henry, N Lynn
   Crew, Katherine D
TI Effect of Acupuncture vs Sham Acupuncture or Waitlist Control on Joint Pain 
SO JAMA
LA English
DT Journal Article
AB IMPORTANCE: Musculoskeletal symptoms are the most common adverse effects of 
   aromatase inhibitors and often result in therapy discontinuation. Small studies 
   suggest that acupuncture may decrease aromatase inhibitor-related joint symptoms. 
   OBJECTIVE: To determine the effect of acupuncture in reducing aromatase 
   inhibitor-related joint pain. DESIGN, SETTING, AND PATIENTS: Randomized clinical 
   trial conducted at 11 academic centers and clinical sites in the United States 
   from March 2012 to February 2017 (final date of follow-up, September 5, 2017). 
   Eligible patients were postmenopausal women with early-stage breast cancer who 
   were taking an aromatase inhibitor and scored at least 3 on the Brief Pain 
   Inventory Worst Pain (BPI-WP) item (score range, 0-10; higher scores indicate 
   greater pain). INTERVENTIONS: Patients were randomized 2:1:1 to the true 
   acupuncture (n = 110), sham acupuncture (n = 59), or waitlist control (n = 57) 
   group. True acupuncture and sham acupuncture protocols consisted of 12 
   acupuncture sessions over 6 weeks (2 sessions per week), followed by 1 session 
   per week for 6 weeks. The waitlist control group did not receive any 
   intervention. All participants were offered 10 acupuncture sessions to be used 
   between weeks 24 and 52. MAIN OUTCOMES AND MEASURES: The primary end point was 
   the 6-week BPI-WP score. Mean 6-week BPI-WP scores were compared by study group 
   using linear regression, adjusted for baseline pain and stratification factors 
   (clinically meaningful difference specified as 2 points). RESULTS: Among 226 
   randomized patients (mean [SD] age, 60.7 [8.6] years; 88% white; mean [SD] 
   baseline BPI-WP score, 6.6 [1.5]), 206 (91.1%) completed the trial. From baseline 
   to 6 weeks, the mean observed BPI-WP score decreased by 2.05 points (reduced 
   pain) in the true acupuncture group, by 1.07 points in the sham acupuncture 
   group, and by 0.99 points in the waitlist control group. The adjusted difference 
   for true acupuncture vs sham acupuncture was 0.92 points (95% CI, 0.20-1.65; 
   P = .01) and for true acupuncture vs waitlist control was 0.96 points (95% CI, 
   0.24-1.67; P = .01). Patients in the true acupuncture group experienced more 
   grade 1 bruising compared with patients in the sham acupuncture group (47% vs 
   25%; P = .01). CONCLUSIONS AND RELEVANCE: Among postmenopausal women with 
   early-stage breast cancer and aromatase inhibitor-related arthralgias, true 
   acupuncture compared with sham acupuncture or with waitlist control resulted in a 
   statistically significant reduction in joint pain at 6 weeks, although the 
   observed improvement was of uncertain clinical importance. TRIAL REGISTRATION: 
   ClinicalTrials.gov Identifier: NCT01535066.
C1 Columbia University Medical Center, New York, New York.
   Fred Hutchinson Cancer Research Center, Seattle, Washington.
   SWOG Statistics and Data Management Center, Seattle, Washington.
   Fred Hutchinson Cancer Research Center, Seattle, Washington.
   Mount Sinai Hospital, New York, New York.
   Fred Hutchinson Cancer Research Center, Seattle, Washington.
   SWOG Statistics and Data Management Center, Seattle, Washington.
   Fred Hutchinson Cancer Research Center, Seattle, Washington.
   SWOG Statistics and Data Management Center, Seattle, Washington.
   Kaiser Permanente Medical Center, Walnut Creek, California.
   Spectrum Health Medical Group, Grand Rapids, Michigan.
   NCORP of the Carolinas (Greenville Health System), Greenville, South Carolina.
   St Luke's Mountain States Tumor Institute (PCRC NCORP), Boise, Idaho.
   Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland.
   AIM Specialty Health, Chicago, Illinois.
   University of Utah Huntsman Cancer Institute, Salt Lake City.
NR 0
TC 0
SN 1538-359
EI 0098-748
J9 JAMA
PD JUL 13
PY 2018
VL 320
IS 2
BP 167
EP 176
DI 10.1001/jama.2018.8907 
PG 9
WC Acupuncture Therapy; adverse effects; Adult; Aged; Aged, 80 and over; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Female; Humans; Middle Aged; Neoplasm Staging; Postmenopause; Single-Blind Method; Waiting Lists
UT PubMed:29998338
PM 29998338
DA 2018-07-13
ER

PT J
AU Ben-Arye, E
   Hausner, D
   Samuels, N
   Gamus, D
   Lavie, O
   Tadmor, T
   Gressel, O
   Agbarya, A
   Attias, S
   David, A
   Schiff, E
AF Ben-Arye, Eran
   Hausner, David
   Samuels, Noah
   Gamus, Dorit
   Lavie, Ofer
   Tadmor, Tamar
   Gressel, Orit
   Agbarya, Abed
   Attias, Samuel
   David, Adi
   Schiff, Elad
TI Impact of acupuncture and integrative therapies on chemotherapy-induced 
SO Cancer
LA English
DT Journal Article
DE acupuncture; chemotherapy-induced peripheral neuropathy; integrative medicine; integrative oncology; pain
AB BACKGROUND: To explore the impact of acupuncture with other complementary and 
   integrative medicine (CIM) modalities on chemotherapy-induced peripheral 
   neuropathy (CIPN) and quality of life (QoL) in oncology patients. METHODS: In 
   this prospective, pragmatic, and patient-preference study, patients with CIPN 
   were treated with acupuncture and CIM therapies (intervention group) or standard 
   care alone (controls) for 6 weeks. Patients in the intervention arm were 
   randomized to twice-weekly acupuncture-only (group A) or acupuncture with 
   additional manual-movement or mind-body CIM therapies (group B). Severity of CIPN 
   was assessed at baseline and at 6 weeks using the Functional Assessment of Cancer 
   Therapy-Taxane (FACT-Tax) tool. Other QoL-related outcomes were assessed with the 
   European Organization for Research and Treatment of Cancer Quality of Life 
   Questionnaire (EORTC); and the Measure Yourself Concerns and Well-being 
   questionnaire. Von Frey measurements examined perception thresholds. RESULTS: Of 
   168 participants, 136 underwent the study intervention (group A, 69; group B, 
   67), with 32 controls. Baseline-to-6-week assessment scores improved 
   significantly in the intervention arm (vs controls) on FACT-Tax (p = .038) and 
   emotional well-being (p = .04) scores; FACT-TAX scores for hand numbness/tingling 
   (p = .007) and discomfort (p < .0001); and EORTC physical functioning (p = .045). 
   Intervention groups A and B showed improved FACT-Tax physical well-being 
   (p < .001), FACT-TAX total score (p < .001), FACT-TAX feet discomfort (p = .003), 
   and EORTC pain (p = .017) scores. CONCLUSIONS: Acupuncture, with or without CIM 
   modalities, can relieve CIPN-related symptoms during oncology treatment. This is 
   most pronounced for hand numbness, tingling, pain, discomfort, and for physical 
   functioning.
C1 Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, Haifa, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 
   Tal Center for Integrative Medicine, Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
   Palliative Care Service, Chaim Sheba Medical Center, Ramat Gan, Israel.
   Center for Integrative Complementary Medicine, Shaarei Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
   Tal Center for Integrative Medicine, Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
   Complementary and Integrative Medicine Service, Sheba Medical Center, Ramat-Gan, 
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Unit of Hematology, Bnai Zion Medical Center, Haifa, Israel.
   Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, Haifa, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 
   Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, Haifa, Israel.
   Institute of Oncology, Bnai Zion Medical Center, Haifa, Israel.
   Department of Internal Medicine & Integrative Medicine Service, Bnai-Zion, Medical Center, Haifa, Israel.
   Palliative Care Service, Chaim Sheba Medical Center, Ramat Gan, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Department of Internal Medicine & Integrative Medicine Service, Bnai-Zion, 
NR 0
TC 0
SN 1097-014
EI 
J9 Cancer
PD AUG 13
PY 2022
VL 128
IS 20
BP 3641
EP 3652
DI 10.1002/cncr.34422 
PG 11
WC Acupuncture Therapy; Antineoplastic Agents; adverse effects; Humans; Hypesthesia; chemically induced; Neoplasms; drug therapy; Pain; chemically induced; Peripheral Nervous System Diseases; chemically induced; Prospective Studies; Quality of Life; Taxoids; therapeutic use
UT PubMed:35960141
PM 35960141
DA 2022-08-13
ER

PT J
AU Chen, T
   Zhang, WW
   Chu, YX
   Wang, YQ
AF Chen, Teng
   Zhang, Wen Wen
   Chu, Yu-Xia
   Wang, Yan-Qing
TI Acupuncture for Pain Management: Molecular Mechanisms of Action.
SO The American journal of Chinese medicine
LA English
DT Review
DE Electroacupuncture; Glial Cells; Manual Acupuncture; Pain Modulation; Review
AB Acupuncture reduces pain by activating specific areas called acupoints on the 
   patient's body. When these acupoints are fully activated, sensations of soreness, 
   numbness, fullness, or heaviness called De qi or Te qi are felt by clinicians and 
   patients. There are two kinds of acupuncture, manual acupuncture and 
   electroacupuncture (EA). Compared with non-acupoints, acupoints are easily 
   activated on the basis of their special composition of blood vessels, mast cells, 
   and nerve fibers that mediate the acupuncture signals. In the spinal cord, EA can 
   inhibit glial cell activation by down-regulating the chemokine CX3CL1 and 
   increasing the anti-inflammatory cytokine interleukin-10. This inhibits P38 
   mitogen-activated protein kinase and extracellular signal-regulated kinase 
   pathways, which are associated with microglial activation of the C-Jun N-terminal 
   kinase signaling pathway and subsequent astrocyte activation. The inactivation of 
   spinal microglia and astrocytes mediates the immediate and long-term analgesic 
   effects of EA, respectively. A variety of pain-related substances released by 
   glial cells such as the proinflammatory cytokines tumor necrosis factor [Formula: 
   see text], interleukin-1[Formula: see text], interleukin-6, and prostaglandins 
   such as prostaglandins E2 can also be reduced. The descending pain modulation 
   system in the brain, including the anterior cingulated cortex, the periaqueductal 
   gray, and the rostral ventromedial medulla, plays an important role in EA 
   analgesia. Multiple transmitters and modulators, including endogenous opioids, 
   cholecystokinin octapeptide, 5-hydroxytryptamine, glutamate, noradrenalin, 
   dopamine, [Formula: see text]-aminobutyric acid, acetylcholine, and orexin A, are 
   involved in acupuncture analgesia. Finally, the "Acupuncture [Formula: see text]" 
   strategy is introduced to help clinicians achieve better analgesic effects, and a 
   newly reported acupuncture method called acupoint catgut embedding, which injects 
   sutures made of absorbable materials at acupoints to achieve long-term effects, 
   is discussed.
C1 Department of Integrative Medicine and Neurobiology, Institutes of Integrative Medicine School of Basic Medical Sciences, Institutes of Brain Science, BrainScience Collaborative Innovation Center, State Key Laboratory of MedicalNeurobiology and MOE Frontiers Center for Brain Science, Fudan UniversityShanghai, P. R. China.
   Department of Integrative Medicine and Neurobiology, Institutes of Integrative Medicine School of Basic Medical Sciences, Institutes of Brain Science, BrainScience Collaborative Innovation Center, State Key Laboratory of MedicalNeurobiology and MOE Frontiers Center for Brain Science, Fudan UniversityShanghai, P. R. China.
   Department of Integrative Medicine and Neurobiology, Institutes of Integrative Medicine School of Basic Medical Sciences, Institutes of Brain Science, BrainScience Collaborative Innovation Center, State Key Laboratory of MedicalNeurobiology and MOE Frontiers Center for Brain Science, Fudan UniversityShanghai, P. R. China.
   Department of Integrative Medicine and Neurobiology, Institutes of Integrative Medicine School of Basic Medical Sciences, Institutes of Brain Science, BrainScience Collaborative Innovation Center, State Key Laboratory of MedicalNeurobiology and MOE Frontiers Center for Brain Science, Fudan UniversityShanghai, P. R. China.
NR 0
TC 0
SN 1793-685
EI 
J9 Am J Chin Med
PD MAY 19
PY 2020
VL 48
IS 4
BP 793
EP 811
DI 10.1142/S0192415X20500408 
PG 18
WC Acupuncture Analgesia; methods; Acupuncture Points; Adrenocorticotropic Hormone; physiology; Animals; Brain; blood supply; Chemokine CX3CL1; metabolism; Cytokines; metabolism; Dopamine; physiology; Electroacupuncture; Glutamic Acid; physiology; Hemodynamics; Humans; JNK Mitogen-Activated Protein Kinases; metabolism; MAP Kinase Signaling System; physiology; Neuroglia; physiology; Neurotransmitter Agents; physiology; Norepinephrine; physiology; Opioid Peptides; physiology; Serotonin; physiology; Sincalide; physiology; Spinal Cord; cytology; gamma-Aminobutyric Acid; physiology; p38 Mitogen-Activated Protein Kinases; metabolism
UT PubMed:32420752
PM 32420752
DA 2020-05-19
ER

PT J
AU Lu, W
   Giobbie-Hurder, A
   Freedman, RA
   Shin, IH
   Lin, NU
   Partridge, AH
   Rosenthal, DS
   Ligibel, JA
AF Lu, Weidong
   Giobbie-Hurder, Anita
   Freedman, Rachel A
   Shin, Im Hee
   Lin, Nancy U
   Partridge, Ann H
   Rosenthal, David S
   Ligibel, Jennifer A
TI Acupuncture for Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer 
SO The oncologist
LA English
DT Journal Article
DE Acupuncture; Breast cancer survivors; Chemotherapy-induced peripheral neuropathy; Quality of life; Taxane
AB BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most 
   debilitating long-term side effects in breast cancer survivors. We conducted a 
   randomized controlled pilot trial to assess the feasibility, safety, and effects 
   of an acupuncture intervention on CIPN in this population. PATIENTS AND METHODS: 
   Women with stage I-III breast cancer with grade 1 or higher CIPN after 
   taxane-containing adjuvant chemotherapy were randomized 1:1 to an immediate 
   acupuncture (IA) arm or to a waitlist control group (CG). Participants in the IA 
   arm received 18 sessions of acupuncture over 8 weeks, then received no additional 
   acupuncture. Patients in the CG arm received usual care over 8 weeks, followed by 
   nine sessions of acupuncture over 8 weeks. Measures including Patient 
   Neurotoxicity Questionnaire (PNQ), Functional Assessment of Cancer 
   Therapy-Neurotoxicity subscale (FACT-NTX), and Brief Pain Inventory-short form 
   (BPI-SF) were collected at baseline and at 4, 8, and 16 weeks after enrollment. 
   RESULTS: Forty women (median age, 54) were enrolled (20 to IA and 20 to CG), with 
   median time between completion of chemotherapy and enrollment of 14 months (range 
   1-92). At 8 weeks, participants in the IA arm experienced significant 
   improvements in PNQ sensory score (-1.0 ± 0.9 vs. -0.3 ± 0.6; p = .01), FACT-NTX 
   summary score (8.7 ± 8.9 vs. 1.2 ± 5.4; p = .002), and BPI-SF pain severity score 
   (-1.1 ± 1.7 vs. 0.3 ± 1.5; p = .03), compared with those in the CG arm. No 
   serious side effects were observed. CONCLUSION: Women with CIPN after adjuvant 
   taxane therapy for breast cancer experienced significant improvements in 
   neuropathic symptoms from an 8-week acupuncture treatment regimen. Additional 
   larger studies are needed to confirm these findings. IMPLICATIONS FOR PRACTICE: 
   Chemotherapy-induced peripheral neuropathy (CIPN) is a toxicity that often 
   persists for months to years after the completion of adjuvant chemotherapy for 
   early breast cancer. In a randomized pilot trial of 40 breast cancer survivors 
   with CIPN, an 8-week acupuncture intervention (vs. usual care) led to a 
   statistically and clinically significant improvement in subjective sensory 
   symptoms including neuropathic pain and paresthesia. Given the lack of effective 
   therapies and established safety profile of acupuncture, clinicians may consider 
   acupuncture as a treatment option for mild to moderate CIPN in practice.
C1 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
   Division of Biostatistics, Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
   Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
   Department of Medical Statistics and Informatics, School of Medicine at the Catholic University of Daegu, Daegu, Republic of Korea.
   Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
   Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
   Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
   Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
NR 0
TC 0
SN 1549-490
EI 1083-715
J9 Oncologist
PD APR 17
PY 2020
VL 25
IS 4
BP 310
EP 318
DI 10.1634/theoncologist.2019-0489 
PG 8
WC Acupuncture Therapy; Antineoplastic Agents; adverse effects; Breast Neoplasms; drug therapy; Cancer Survivors; Child; Child, Preschool; Female; Humans; Infant; Peripheral Nervous System Diseases; chemically induced; Pilot Projects
UT PubMed:32297442
PM 32297442
DA 2020-04-17
ER

PT J
AU Lopes-Júnior, LC
   Rosa, GS
   Pessanha, RM
   Schuab, SIPC
   Nunes, KZ
   Amorim, MHC
AF Lopes-Júnior, Luís Carlos
   Rosa, Gabriela Sylvestre
   Pessanha, Raphael Manhães
   Schuab, Sara Isabel Pimentel de Carvalho
   Nunes, Karolini Zuqui
   Amorim, Maria Helena Costa
TI Efficacy of the complementary therapies in the management of cancer pain in 
SO Revista latino-americana de enfermagem
LA English
DT Journal Article
AB OBJECTIVE: to synthesize the knowledge and to critically evaluate the evidences 
   arising from randomized controlled trials on the efficacy of the complementary 
   therapies in the management of cancer pain in adult patients with cancer in 
   palliative care. METHOD: a systematic review guided by the Preferred Reporting 
   Items for Systematic Reviews and Meta-Analyses. The search for articles in the 
   MEDLINE, ISI Web of Knowledge, CENTRAL Cochrane, and PsycINFO databases, as well 
   as the manual search, selection of studies, data extraction, and methodological 
   assessment using the Cochrane Bias Risk tool were performed independently by two 
   reviewers. RESULTS: eight hundred and fifteen (815) studies were identified, six 
   of them being selected and analyzed, of which three used massage therapy, one 
   study used a combination of progressive muscle relaxation and guided imaging, and 
   another two studies used acupuncture. Most of the studies had an uncertain risk 
   of bias (n=4; 67%). CONCLUSION: while the evidence from the studies evaluating 
   the use of massage therapy or the use of progressive muscle relaxation and guided 
   imaging for the management of cancer pain in these patients demonstrated 
   significant benefits, the other two studies that evaluated the use of acupuncture 
   as a complementary therapy showed contradictory results, therefore, needing more 
   research studies to elucidate such findings.
NR 0
TC 0
SN 1518-834
EI 0104-116
J9 Rev Lat Am Enfermagem
PD OCT 8
PY 2020
VL 28
IS 
BP e3377
EP e3377
DI 10.1590/1518-8345.4213.3377 
PG 1
WC Acupuncture Therapy; Adult; Cancer Pain; therapy; Complementary Therapies; Humans; Massage; Neoplasms; complications; Palliative Care
UT PubMed:33027406
PM 33027406
DA 2020-10-08
ER

PT J
AU Wang, W
   Liu, Y
   Yang, X
   Sun, J
   Yue, Z
   Lu, D
   Zhou, K
   Sun, Y
   Hou, A
   Zang, Z
   Jin, X
   Liu, C
   Wang, Y
   Yu, J
   Zhu, L
   Liu, Z
AF Wang, Weiming
   Liu, Yan
   Yang, Xiaofang
   Sun, Jianhua
   Yue, Zenghui
   Lu, Dianrong
   Zhou, Kehua
   Sun, Yuanjie
   Hou, Aihua
   Zang, Zhiwei
   Jin, Xiaoqing
   Liu, Chao
   Wang, Yuhang
   Yu, Jinna
   Zhu, Lili
   Liu, Zhishun
TI Effects of Electroacupuncture for Opioid-Induced Constipation in Patients With 
SO JAMA network open
LA English
DT Journal Article
AB IMPORTANCE: Opioid-induced constipation (OIC) is prevalent among patients treated 
   with opioids for cancer pain. Safe and effective therapies for OIC in patients 
   with cancer remain an unmet need. OBJECTIVE: To determine the efficacy of 
   electroacupuncture (EA) for OIC in patients with cancer. DESIGN, SETTING, AND 
   PARTICIPANTS: This randomized clinical trial was conducted at 6 tertiary 
   hospitals in China among 100 adult patients with cancer who were screened for OIC 
   and enrolled between May 1, 2019, and December 11, 2021. INTERVENTIONS: Patients 
   were randomized to receive 24 sessions of EA or sham electroacupuncture (SA) over 
   8 weeks and then were followed up for 8 weeks after treatment. MAIN OUTCOMES AND 
   MEASURES: The primary outcome was the proportion of overall responders, defined 
   as patients who had at least 3 spontaneous bowel movements (SBMs) per week and an 
   increase of at least 1 SBM from baseline in the same week for at least 6 of the 8 
   weeks of the treatment period. All statistical analyses were based on the 
   intention-to-treat principle. RESULTS: A total of 100 patients (mean [SD] age, 
   64.4 [10.5] years; 56 men [56.0%]) underwent randomization; 50 were randomly 
   assigned to each group. Among them, 44 of 50 patients (88.0%) in the EA group and 
   42 of 50 patients (84.0%) in the SA group received at least 20 (≥83.3%) sessions 
   of treatment. The proportion of overall responders at week 8 was 40.1% (95% CI, 
   26.1%-54.1%) in the EA group and 9.0% (95% CI, 0.5%-17.4%) in the SA group 
   (difference between groups, 31.1 percentage points [95% CI, 14.8-47.6 percentage 
   points]; P < .001). Compared with SA, EA provided greater relief for most OIC 
   symptoms and improved quality of life among patients with OIC. Electroacupuncture 
   had no effects on cancer pain and its opioid treatment dosage. 
   Electroacupuncture-related adverse events were rare, and, if any, all were mild 
   and transient. CONCLUSIONS AND RELEVANCE: This randomized clinical trial found 
   that 8-week EA treatment could increase weekly SBMs with a good safety profile 
   and improve quality of life for the treatment of OIC. Electroacupuncture thus 
   provided an alternative option for OIC in adult patients with cancer. TRIAL 
   REGISTRATION: ClinicalTrials.gov Identifier: NCT03797586.
C1 Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
   Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   College of Acumox and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
   Department of Acupuncture Rehabilitation, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   College of Acupuncture and Tuina, Hunan University of Chinese Medicine, Changsha, Hunan, China.
   Department of Oncology, Wang Jing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
   Department of Hospital Medicine, ThedaCare Regional Medical Center-Appleton, Appleton, Wisconsin.
   Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
   Department of Oncology, Yantai Hospital of Traditional Chinese Medicine, Yantai, China.
   Department of Acupuncture, Yantai Hospital of Traditional Chinese Medicine, Yantai, China.
   Department of Acupuncture, Zhejiang Hospital, Hangzhou, China.
   College of Acumox and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
   Department of Acupuncture Rehabilitation, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
   Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
   Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
NR 0
TC 0
SN 2574-380
EI 
J9 JAMA Netw Open
PD FEB 23
PY 2023
VL 6
IS 2
BP e230310
EP e230310
DI 10.1001/jamanetworkopen.2023.0310 
PG 1
WC Adult; Male; Humans; Middle Aged; Analgesics, Opioid; therapeutic use; Constipation; chemically induced; Electroacupuncture; Opioid-Induced Constipation; drug therapy; Cancer Pain; drug therapy; Quality of Life; Neoplasms; drug therapy; China
UT PubMed:36811861
PM 36811861
DA 2023-02-23
ER

PT J
AU Yeh, ML
   Liao, RW
   Yeh, PH
   Lin, CJ
   Wang, YJ
AF Yeh, Mei-Ling
   Liao, Ru-Wen
   Yeh, Pin-Hsuan
   Lin, Chuan-Ju
   Wang, Yu-Jen
TI Acupuncture-related interventions improve chemotherapy-induced peripheral 
SO BMC complementary medicine and therapies
LA English
DT Journal Article
DE Acupuncture; Chemotherapy-induced peripheral neuropathy; Electrical stimulation; Moxibustion; Pain; Quality of life
AB BACKGROUND: The previous effects of acupuncture-related interventions in 
   improving chemotherapy-induced peripheral neuropathy (CIPN) symptoms and quality 
   of life (QoL) remain unclear in terms of pairwise comparisons. AIMS: This 
   systematic review and network meta-analysis aimed to determine the hierarchical 
   effects of acupuncture-related interventions on symptoms, pain, and QoL 
   associated with CIPN in cancer patients undergoing chemotherapy. METHODS: Nine 
   electronic databases were searched, including PubMed, Embase, Cochrane Library, 
   EBSCO, Medline Ovid, Airiti Library, China National Knowledge Infrastructure 
   (CNKI), China Journal full-text database (CJFD), and Wanfang. Medical subject 
   heading terms and text words were used to search for eligible randomized 
   controlled trials published from database inception to May 2023. RESULTS: A total 
   of 33 studies involving 2,027 participants were included. Pairwise meta-analysis 
   revealed that acupuncture-related interventions were superior to usual care, 
   medication, or dietary supplements in improving CIPN symptoms, CIPN pain, and 
   QoL. Furthermore, network meta-analysis indicated that acupuncture plus 
   electrical stimulation (acupuncture-E) had the greatest overall effect among the 
   various interventions. The surface under the cumulative ranking curve (SUCRA) 
   revealed that acupuncture-E ranked the highest in improving CINP symptoms. 
   Acupuncture alone was most effective in reducing CIPN pain, and acupuncture plus 
   moxibustion (acupuncture-M) ranked highest in enhancing QoL. CONCLUSION: This 
   finding suggests that acupuncture-related interventions can provide patients with 
   benefits in improving CIPN symptoms, pain, and QoL. In particular, acupuncture-E 
   could be the most effective approach in which the provided evidence offers 
   diverse options for cancer patients and healthcare professionals. IMPLICATION FOR 
   THE PROFESSION AND/OR PATIENT CARE: These findings provide valuable insights into 
   the potential benefits of acupuncture-related interventions for managing 
   symptoms, pain, and QoL associated with CIPN in patients undergoing chemotherapy. 
   Among the various interventions studied, overall, acupuncture-E had the most 
   significant impact and was effective for a minimum duration of 3 weeks. On the 
   other hand, transcutaneous electrical acupoint/nerve stimulation (TEAS) was 
   identified as a noninvasive and feasible alternative for patients who had 
   concerns about needles or the risk of bleeding. It is recommended that TEAS 
   interventions should be carried out for a longer period, preferably lasting 
   4 weeks, to achieve optimal outcomes. TRIAL REGISTRATION: The study protocol was 
   registered in the International Prospective Register of Systematic Reviews. 
   REGISTRATION NUMBER: CRD42022319871.
C1 Department of Nursing, National Taipei University of Nursing and Health Sciences, No. 365, Minte Rd., Peitou Dist., Taipei City, 11219, Taiwan.
   Department of Nursing, Taipei Tzu Chi Hospital, No. 289, Jianguo Rd., Xindian Dist., New Taipei City, 23142, Taiwan.
   Department of Nursing, National Taipei University of Nursing and Health Sciences, No. 365, Minte Rd., Peitou Dist., Taipei City, 11219, Taiwan.
   Department of Nursing, Hsinchu Cathay General Hospital, No. 678, Sec. 2 Zhonghua Rd., East Dist., Hsinchu City, 300003, Taiwan. cgh306214@cgh.org.tw.
   Department of Nursing, Chang Gung University of Science and Technology, No. 261, Wenhwa 1 Rd., Guishan Dist., Taoyuan City, 333324, Taiwan.yjwang@mail.cgust.edu.tw.
NR 0
TC 0
SN 2662-767
EI 
J9 BMC Complement Med Ther
PD AUG 20
PY 2024
VL 24
IS 1
BP 310
EP 310
DI 10.1186/s12906-024-04603-1 
PG 0
WC Humans; Peripheral Nervous System Diseases; chemically induced; Acupuncture Therapy; methods; Antineoplastic Agents; adverse effects; Quality of Life; Neoplasms; drug therapy; Randomized Controlled Trials as Topic
UT PubMed:39160496
PM 39160496
DA 2024-08-20
ER

PT J
AU Tao, WW
   Jiang, H
   Tao, XM
   Jiang, P
   Sha, LY
   Sun, XC
AF Tao, Wei-Wei
   Jiang, Hua
   Tao, Xiao-Mei
   Jiang, Ping
   Sha, Li-Yan
   Sun, Xian-Ce
TI Effects of Acupuncture, Tuina, Tai Chi, Qigong, and Traditional Chinese Medicine 
SO Journal of pain and symptom management
LA English
DT Review
DE Acupuncture; Qigong; Tai Chi; cancer; massage; meta-analysis; symptom management
AB CONTEXT: Most cancer patients suffer from both the disease itself and symptoms 
   induced by conventional treatment. Available literature on the clinical effects 
   on cancer patients of acupuncture, Tuina, Tai Chi, Qigong, and Traditional 
   Chinese Medicine Five-Element Music Therapy (TCM-FEMT) reports controversial 
   results. OBJECTIVES: The primary objective of this meta-analysis was to evaluate 
   the effect of acupuncture, Tuina, Tai Chi, Qigong, and TCM-FEMT on various 
   symptoms and quality of life (QOL) in patients with cancer; risk of bias for the 
   selected trials also was assessed. METHODS: Studies were identified by searching 
   electronic databases (MEDLINE via both PubMed and Ovid, Cochrane Central, China 
   National Knowledge Infrastructure, Chinese Scientific Journal Database, China 
   Biology Medicine, and Wanfang Database). All randomized controlled trials (RCTs) 
   using acupuncture, Tuina, Tai Chi, Qigong, or TCM-FEMT published before October 
   2, 2014, were selected, regardless of whether the article was published in 
   Chinese or English. RESULTS: We identified 67 RCTs (5465 patients) that met our 
   inclusion criteria to perform this meta-analysis. Analysis results showed that a 
   significant combined effect was observed for QOL change in patients with terminal 
   cancer in favor of acupuncture and Tuina (Cohen's d: 0.21-4.55, P < 0.05), 
   whereas Tai Chi and Qigong had no effect on QOL of breast cancer survivors (P > 
   0.05). The meta-analysis also demonstrated that acupuncture produced 
   small-to-large effects on adverse symptoms including pain, fatigue, sleep 
   disturbance, and some gastrointestinal discomfort; however, no significant effect 
   was found on the frequency of hot flashes (Cohen's d = -0.02; 95% CI = -1.49 to 
   1.45; P = 0.97; I(2) = 36%) and mood distress (P > 0.05). Tuina relieved 
   gastrointestinal discomfort. TCM-FEMT lowered depression level. Tai Chi improved 
   vital capacity of breast cancer patients. High risk of bias was present in 74.63% 
   of the selected RCTs. Major sources of risk of bias were lack of blinding, 
   allocation concealment, and incomplete outcome data. CONCLUSION: Taken together, 
   although there are some clear limitations regarding the body of research reviewed 
   in this study, a tentative conclusion can be reached that acupuncture, Tuina, Tai 
   Chi, Qigong, or TCM-FEMT represent beneficial adjunctive therapies. Future study 
   reporting in this field should be improved regarding both method and content of 
   interventions and research methods.
C1 College of Nursing, Dalian Medical University, Dalian, People's Republic of China. 
   School of Nursing, Peking University, Beijing, People's Republic of China.
   Beijing Shijitan Hospital, Beijing, People's Republic of China.
   Graduate School, Dalian Medical University, Dalian, People's Republic of China. 
   College of Nursing, Dalian Medical University, Dalian, People's Republic of China.
   College of Public Health, Dalian Medical University, Dalian, People's Republic of China.
EM dywx.2009@163.com
NR 0
TC 0
SN 1873-651
EI 
J9 J Pain Symptom Manage
PD FEB 18
PY 2016
VL 51
IS 4
BP 728
EP 747
DI 10.1016/j.jpainsymman.2015.11.027 
PG 19
WC Acupuncture Therapy; Disease Management; Humans; Medicine, Chinese Traditional; methods; Music Therapy; methods; Neoplasms; physiopathology; Qigong; Quality of Life; Randomized Controlled Trials as Topic; Tai Ji
UT PubMed:26880252
PM 26880252
DA 2016-02-18
ER

PT J
AU Wang, Z
   Xu, H
   Wang, Z
   Zhou, H
   Diao, J
   Zhang, L
   Wang, Y
   Li, M
   Zhou, Y
AF Wang, Zhen
   Xu, Hui
   Wang, Zheng
   Zhou, Hang
   Diao, Jieyao
   Zhang, Lijuan
   Wang, Yu
   Li, Miaoxiu
   Zhou, Yunfeng
TI Effects of externally-applied, non-pharmacological Interventions on short- and 
SO Frontiers in immunology
LA English
DT Journal Article
DE efficacy; externally-applied; inflammatory cytokine; knee osteoarthritis; network meta-analysis; non-pharmacological interventions; short- and long-term
AB BACKGROUND: With the continuous development of clinical medicine, an increasing 
   number of non-pharmacological interventions have been applied for the treatment 
   of knee osteoarthritis (KOA), with the results of several recent randomized 
   controlled trials (RCTs) showing that a variety of externally-applied, 
   non-pharmacological interventions (EANPI) can improve symptoms and inflammation 
   in patients with KOA. However, the relative benefits and disadvantages of 
   non-drug therapies remain uncertain, and an optimal treatment strategy has not 
   yet been determined. OBJECTIVE: This study applied network meta-analysis (NMA) to 
   compare and rank the effectiveness of EANPI on the short- and long-term clinical 
   symptoms and inflammatory cytokine levels in patients with KOA. METHODS: Two 
   independent researchers searched online databases and performed manual retrieval 
   of related citations to identify RCTs that met the selection criteria for the 
   network meta-analysis. These researchers retrieved studies indexed from database 
   inception to August 2023 and performed data extraction and assessment of the risk 
   of bias. RESULTS: The analysis included 80 RCTs involving 8440 participants and 
   nine externally-applied, non-pharmacological therapies, namely extracorporeal 
   shock wave, radiofrequency, acupotomy, laser therapy, Tuina therapy, kinesio 
   taping, electroacupuncture, platelet-rich plasma injection, and ozone therapy. 
   The treatment courses ranged from 1 to 12 weeks, with follow-up periods ranging 
   from 4 to 24 weeks. The results of the NMA indicated that each non-drug therapy 
   was superior to sham intervention in improving all outcome indicators. Except for 
   the visual analog scale (VAS) and Western Ontario MacMaster (WOMAC) pain 
   outcomes, all non-drug therapies had better efficacy than pharmacological 
   treatments. For short-term VAS and tumor necrosis factor-alpha (TNF-α), 
   extracorporeal shock wave performed better than other therapies (90.2% and 85.2% 
   respectively). Radiofrequency therapy may be the most promising method to reduce 
   long-term VAS, short- and long-term WOMAC pain, and interleukin (IL)-1β level 
   (84.8%, 97.8%, 90.1%, 94.8% respectively). Tuina therapy may be a significant 
   choice for short- and long-term outcomes of WOMAC function and range of motion 
   (ROM). CONCLUSIONS: The results of the comprehensive comparison of the outcome 
   indicators in 9 different EANPI indicated that radiofrequency and Tuina therapy 
   were more effective and consistently ranked high in improving clinical symptoms 
   in the short and long term. Radiofrequency is effective at relieving pain, and 
   Tuina therapy can be given priority for treatment when hypofunction is the main 
   symptom. EANPI to improve pain symptoms may be related to the regulation of 
   inflammatory cytokine levels, which may be a potential mechanism of action. 
   SYSTEMATIC REVIEW REGISTRATION: 
   https://www.crd.york.ac.uk/prospero/display_record.php?, identifier 
   CRD42023464177.
C1 College of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, China.
   College of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, China.
   Tuina Department, The Third Affiliated Hospital of Henan University of Chinese 
   College of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, China.
   College of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, China.
   College of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, China.
   Rehabilitation Department, Jiaozuo Coal Industry (Group) Co. Ltd., Central Hospital, Jiaozuo, China.
   College of Computer Science, Xidian University, Xian, China.
   College of Acupuncture and Massage, Shanghai University of Chinese Medicine, Shanghai, China.
   College of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, China.
NR 0
TC 0
SN 1664-322
EI 
J9 Front Immunol
PD DEC 29
PY 2023
VL 14
IS 
BP 1309751
EP 1309751
DI 10.3389/fimmu.2023.1309751 
PG 0
WC Humans; Osteoarthritis, Knee; therapy; Cytokines; Pain; Acupuncture Therapy
UT PubMed:38155966
PM 38155966
DA 2023-12-29
ER

PT J
AU El, Iskandarani S
   Deng, G
AF El Iskandarani, Sarah
   Deng, Gary
TI Acupuncture in hematologic malignancies and hematopoietic cell transplantation.
SO Blood reviews
LA English
DT Review
DE Acupuncture; Cancer symptoms; Integrative medicine; Leukemia; Lymphoma
AB Acupuncture is an integrative medicine modality that has been used historically 
   and studied recently for managing various symptoms and diseases. Patients with 
   hematological malignancies often experience a high symptom burden including pain, 
   fatigue, nausea, vomiting, and insomnia. Pharmacological interventions are the 
   mainstay of managing these symptoms, although they may not provide adequate 
   control or are not well tolerated due to side effects. There have been many 
   randomized controlled trials of acupuncture on reduction of these symptoms. In 
   this review, we will summarize the current evidence on the effect of acupuncture 
   on the management of common symptoms experienced by patients with hematological 
   malignancies and the current understanding of acupuncture's mechanism of action. 
   The evidence is the strongest for reducing pain and nausea vomiting, less strong 
   for symptoms such as peripheral neuropathy, fatigue, constipation, insomnia, 
   night sweat, and pruritus.
C1 Memorial Sloan Kettering Cancer Center, Integrative Medicine Service, New York, NY, USA.
   Memorial Sloan Kettering Cancer Center, Integrative Medicine Service, New York, NY, USA. 
EM dengg@mskcc.org
NR 0
TC 0
SN 1532-168
EI 0268-960
J9 Blood Rev
PD JUN 21
PY 2022
VL 56
IS 
BP 100985
EP 100985
DI 10.1016/j.blre.2022.100985 
PG 0
WC Humans; Sleep Initiation and Maintenance Disorders; etiology; Acupuncture Therapy; adverse effects; Nausea; etiology; Vomiting; etiology; Fatigue; etiology; Hematopoietic Stem Cell Transplantation; adverse effects; Pain; etiology; Hematologic Neoplasms; therapy
UT PubMed:35725779
PM 35725779
DA 2022-06-21
ER

PT J
AU Woodbury, A
   Myles, B
AF Woodbury, Anna
   Myles, Bati
TI Integrative Therapies in Cancer Pain.
SO Cancer treatment and research
LA English
DT Journal Article
AB Integrative medicine is an approach to medical care that embraces all effective 
   therapies including complementary treatments such as acupuncture and hypnosis. 
   There is growing use of complementary therapies in the cancer patient population, 
   making it important that health care providers be aware of both the risks and 
   benefits of treatments that lie outside of the traditional allopathic medicine 
   paradigm. This chapter will explore some of the most common and well-investigated 
   complementary therapies for the treatment and prevention of cancer-related pain. 
   This will include discussions of: acupuncture, dietary supplements, massage, 
   guided imagery and cryotherapy among others. The goal of this is to provide a 
   framework for discussions between medical providers and their patients to ensure 
   safety, discussion of all available treatments, and to facilitate open lines of 
   communication.
C1 Anesthesiology, Veterans Affairs Medical Center, Emory University School of Medicine, Atlanta Veterans Affairs Healthcare System, 1670 Clairmont Rd, Decatur,GA, 30033, USA. anna.woodbury@emory.edu.
   Emergency Medicine Physician, Palliative Care Fellow, Emory University School of Medicine, Atlanta, GA, USA.
NR 0
TC 0
SN 
EI 0927-304
J9 Cancer Treat Res
PD SEP 21
PY 2021
VL 182
IS 
BP 281
EP 302
DI 10.1007/978-3-030-81526-4_18 
PG 21
WC Acupuncture Therapy; Cancer Pain; therapy; Complementary Therapies; Humans; Integrative Medicine; Massage; Neoplasms; complications
UT PubMed:34542889
PM 34542889
DA 2021-09-21
ER

PT J
AU O'Regan, D
   Filshie, J
AF O'Regan, David
   Filshie, Jacqueine
TI Acupuncture and cancer.
SO Autonomic neuroscience : basic & clinical
LA English
DT Review
AB Acupuncture has become a popular complementary treatment in oncology, 
   particularly as patients seek non-pharmacological alternatives to provide symptom 
   control. A considerable body of evidence suggests that acupuncture modulates 
   neurological processes to bring about its effects. This basic research is 
   supported by an increasing number of positive clinical studies of varying 
   quality. Lower quality studies have hampered the widespread acceptability of 
   acupuncture, with some deeming the inter-personal skills of the practitioner to 
   be more powerful than the needle or its equivalent. More recent randomised 
   control trials (RCTs) have sought to settle this controversy, with mixed results. 
   The literature was searched to identify, where possible, RCTs involving 
   acupuncture and various common cancer symptoms. A potential role for acupuncture 
   was found in the following cancer symptoms: pain, nausea and vomiting, 
   xerostomia, hot flushes, fatigue, anxiety, depression and insomnia. Acupuncture 
   is safe with minimal side-effects, and is clinically effective for the management 
   of these symptoms. Continuing research using validated methodology is essential. 
   In the interim, health professionals should be open to explore the use of 
   acupuncture with their cancer patients.
C1 The Royal Marsden Hospital, London and Surrey, UK.
NR 0
TC 0
SN 1872-748
EI 
J9 Auton Neurosci
PD JUL 8
PY 2010
VL 157
IS 1-2
BP 96
EP 100
DI 10.1016/j.autneu.2010.05.001 
PG 4
WC Acupuncture Therapy; methods; Anxiety; etiology; Depression; etiology; Fatigue; etiology; Humans; Nausea; etiology; Neoplasms; physiopathology; Pain; etiology; Pain Management; Randomized Controlled Trials as Topic; standards; Vomiting; etiology; Xerostomia; etiology
UT PubMed:20605536
PM 20605536
DA 2010-07-08
ER

PT J
AU Dios, PD
   Lestón, JS
AF Dios, Pedro Diz
   Lestón, Juan Seoane
TI Oral cancer pain.
SO Oral oncology
LA English
DT Review
AB Pain may be the initial symptom in oral cancer, and is a common complaint both in 
   patients awaiting treatment and in those already in treatment. However, little 
   has been published in the literature on the management of oral cancer pain. 
   Effective pain control requires a multimodal approach in which pharmacological 
   management based on the World Health Organization (WHO) analgesic ladder 
   continues to play an essential role. Although different routes are available for 
   the administration of analgesics, oral delivery continues to be the principal 
   route for pain control in the first instance. Interventional approaches include 
   blockade of a peripheral nerve or of the relevant ganglion, and the use of 
   central neuraxial blockade. The intraventricular or intrathecal administration of 
   opioids, with or without local anaesthetics, has been indicated for severe 
   intractable pain. The development of new treatment modalities provides additional 
   options, though further clinical research is required. There is no evidence of 
   the efficacy of non-pharmacological methods such as acupuncture or transcutaneous 
   nerve stimulation in the management of oral cancer pain. Surgery, radiation 
   therapy, and chemotherapy have also been suggested, but their results have not 
   been quantified.
C1 School of Medicine and Dentistry, Santiago de Compostela University, Santiago de Compostela, Spain. pedro.diz@usc.es
NR 0
TC 0
SN 1879-059
EI 
J9 Oral Oncol
PD MAR 24
PY 2010
VL 46
IS 6
BP 448
EP 51
DI 10.1016/j.oraloncology.2010.02.017 
PG -397
WC Analgesics, Opioid; administration & dosage; Anesthetics, Local; administration & dosage; Carcinoma, Squamous Cell; complications; Early Detection of Cancer; Female; Head and Neck Neoplasms; complications; Humans; Male; Nerve Block; methods; Pain; etiology; Pain Management; Pain Measurement
UT PubMed:20308009
PM 20308009
DA 2010-03-24
ER

PT J
AU Javdan, B
   Cassileth, B
AF Javdan, Bahar
   Cassileth, Barrie
TI Acupuncture Research at Memorial Sloan Kettering Cancer Center.
SO Journal of acupuncture and meridian studies
LA English
DT Review
DE acupuncture; cancer; dyspnea; lung cancer; lymphedema; xerostomia
AB Acupuncture may help treat specific cancer-related symptoms. Here, we summarize 
   our clinical trials that sought to determine acupuncture's role in managing 
   cancer-related symptoms. Trials have been conducted to determine acupuncture's 
   ability to mitigate cancer-related symptoms including dyspnea, fatigue, 
   xerostomia, lymphedema, hot flashes, postoperative ileus, pain and dysfunction 
   after neck dissection, and postthoracotomy pain. Published studies indicate that 
   acupuncture versus placebo acupuncture failed to reduce cancer-related dyspnea. 
   Both true and sham acupuncture alleviated fatigue slightly, but no significant 
   differences between groups emerged. Compared with sham acupuncture, our research 
   showed that acupuncture significantly improved saliva production in patients with 
   xerostomia and significantly reduced lymphedema patients' arm circumference in a 
   pilot study. However, acupuncture failed to significantly reduce hot flashes and 
   was no more successful than sham acupuncture in reducing postoperative ileus. 
   Significant reductions in pain and dysfunction occurred in cancer patients after 
   neck dissection. In a feasibility study, acupuncture was found to be acceptable 
   to lung cancer patients and did not interfere with standard postoperative care. 
   In summary, acupuncture is a potential candidate for the treatment of some 
   important cancer-related symptoms. Large clinical trials and research to 
   investigate mechanistic pathways are warranted.
C1 Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA.
   Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA. 
EM cassileth@mskcc.org
NR 0
TC 0
SN 2093-815
EI 
J9 J Acupunct Meridian Stud
PD JUN 24
PY 2015
VL 8
IS 3
BP 115
EP 21
DI 10.1016/j.jams.2015.03.005 
PG -94
WC Acupuncture Therapy; Biomedical Research; Clinical Trials as Topic; Combined Modality Therapy; adverse effects; Fatigue; etiology; Hot Flashes; etiology; Humans; Lymphedema; etiology; Neoplasms; therapy; New York City; Pain, Postoperative; etiology; Xerostomia; etiology
UT PubMed:26100064
PM 26100064
DA 2015-06-24
ER

PT J
AU Lu, W
   Rosenthal, DS
AF Lu, Weidong
   Rosenthal, David S
TI Acupuncture for cancer pain and related symptoms.
SO Current pain and headache reports
LA English
DT Review
AB Cancer pain is one of most prevalent symptoms in patients with cancer. 
   Acupuncture and related techniques have been suggested for the management of 
   cancer pain. The National Comprehensive Cancer Network guidelines for adult 
   cancer pain recommends acupuncture, as one of several integrative interventions, 
   in conjunction with pharmacologic intervention as needed. This review presents 
   the latest available evidence regarding the use of acupuncture for cancer pain. 
   It also provides "actionable" acupuncture protocols for specific cancer pain 
   conditions and related symptoms in order to provide more clinically relevant 
   solutions for clinicians and cancer patients with pain. These conditions include 
   postoperative cancer pain, postoperative nausea and vomiting, postsurgical 
   gastroparesis syndrome, opioid-induced constipation, opioid-induced pruritus, 
   chemotherapy-induced neuropathy, aromatase inhibitor-associated joint pain, and 
   neck dissection-related pain and dysfunction.
C1 Leonard P. Zakim Center for Integrative Therapies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. weidong_lu@dfci.harvard.edu
NR 0
TC 0
SN 1534-308
EI 1531-343
J9 Curr Pain Headache Rep
PD JAN 23
PY 2013
VL 17
IS 3
BP 321
EP 321
DI 10.1007/s11916-013-0321-3 
PG 0
WC Acupuncture Therapy; methods; Analgesics, Opioid; administration & dosage; Antineoplastic Agents; administration & dosage; Female; Guidelines as Topic; Humans; Male; Nausea; chemically induced; Neoplasms; complications; Pain Management; methods; Pain, Intractable; drug therapy; Treatment Outcome; United States; Vomiting; chemically induced
UT PubMed:23338773
PM 23338773
DA 2013-01-23
ER

PT J
AU Ernst, E
AF Ernst, Edzard
TI Acupuncture.
SO The Lancet. Oncology
LA English
DT Journal Article
C1 Edzard.Ernst@pms.ac.uk
NR 0
TC 0
SN 1474-548
EI 
J9 Lancet Oncol
PD FEB 5
PY 2010
VL 11
IS 1
BP 20
EP 20
DI 10.1016/S1470-2045(09)70399-7 
PG 0
WC Acupuncture Therapy; adverse effects; Analgesia; adverse effects; Antineoplastic Agents; adverse effects; Evidence-Based Medicine; Humans; Nausea; chemically induced; Neoplasms; complications; Pain; etiology; Palliative Care; Quackery; Treatment Outcome
UT PubMed:20129129
PM 20129129
DA 2010-02-05
ER

PT J
AU He, Y
   Xiang, S
   Zhang, D
   Chen, M
AF He, Yi
   Xiang, Shate
   Zhang, Danjun
   Chen, Muzhi
TI Acupuncture treatment for liver cancer pain: A meta-analysis.
SO Journal of surgical oncology
LA English
DT Review
DE acupuncture; liver cancer; meta‐analysis; pain; systematic review
AB Acupuncture treatment is a common intervention for the clinical relief of primary 
   liver cancer (PLC) pain, but there is variability in its efficacy. This review 
   systematically assessed the efficacy and safety of acupuncture treatment for PLC 
   pain by meta-analysis. A total of 17 randomized controlled trial studies 
   involving 1162 patients met the inclusion criteria. This study identified the 
   acupuncture method, treatment duration, and patient age were the main factors 
   affecting the efficacy of acupuncture treatment.
C1 College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, China.
   College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Rheumatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Rheumatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
NR 0
TC 0
SN 1096-909
EI 
J9 J Surg Oncol
PD MAY 20
PY 2024
VL 130
IS 1
BP 83
EP 92
DI 10.1002/jso.27691 
PG 9
WC Humans; Liver Neoplasms; therapy; Cancer Pain; therapy; Acupuncture Therapy; methods; Randomized Controlled Trials as Topic; Pain Management; methods
UT PubMed:38764249
PM 38764249
DA 2024-05-20
ER

PT J
AU Jiao, L
   He, X
   Zhang, J
   Liu, Y
   Luo, Y
   Wei, H
AF Jiao, Liangbo
   He, Xiaoxia
   Zhang, Jihong
   Liu, Yali
   Luo, Yanan
   Wei, Hu
TI Effects of Acupuncture on Cancer Pain in Animal Intervention Studies: A 
SO Integrative cancer therapies
LA English
DT Journal Article
DE ARRIVE; SYRCLE; acupuncture; cancer pain; methodological and reporting quality
AB BACKGROUND: Preclinical studies often provide the evidence base for clinical 
   studies. However, the design and reporting of preclinical trial results are 
   inadequate, resulting in poor reproducibility and clinical translatability. We 
   aimed to systematically evaluate the methodology and reporting quality of animal 
   studies of acupuncture for cancer pain. METHODS: About 7 databases were searched 
   for animal research articles on acupuncture for cancer pain from the beginning of 
   the database to January 31, 2022. ARRIVE guidelines, STRICTA, and SYRCLE risk of 
   bias tools were used to assess the reporting quality and risk of bias of the 
   selected studies. RESULTS: A total of 18 studies were evaluated. Of the 22 items 
   on the SYRCLE tool, only 6 items had a positive reporting rate of more than 50%. 
   Of the 39 items in the ARRIVE guidelines, 14 were rated excellent, and the least 
   frequently reported checklist items were 7. Out of the 17 STRICTA checklist items 
   analyzed, 10 were considered appropriately reported in more than 80% of the 
   studies, while 4 were correctly reported in less than 20%. CONCLUSIONS: Some 
   crucial points in the design, implementation, and reporting of the experiments 
   included in the study were not well developed, which could significantly affect 
   the clarity, reproducibility, and translatability of the experiments. There is a 
   need to fully implement scientific tool guidelines for future experimental 
   studies in order to improve the quality of preclinical studies and facilitate 
   effective translation of their results to the clinic.
C1 The Second People's Hospital of China Three Gorges University, Yichang, Hubei, China.
   Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China ThreeGorges University, Yichang, Hubei, China.
   The Second People's Hospital of China Three Gorges University, Yichang, Hubei, China.
   Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China ThreeGorges University, Yichang, Hubei, China.
   Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China ThreeGorges University, Yichang, Hubei, China.
   Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China ThreeGorges University, Yichang, Hubei, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD NOV 1
PY 2022
VL 21
IS 
BP 15347354221123788
EP 15347354221123788
DI 10.1177/15347354221123788 
PG 1
WC Animals; Cancer Pain; Reproducibility of Results; Acupuncture; Acupuncture Therapy; methods; Neoplasms; therapy
UT PubMed:36314416
PM 36314416
DA 2022-11-01
ER

PT J
AU Paley, CA
   Johnson, MI
   Tashani, OA
   Bagnall, AM
AF Paley, Carole A
   Johnson, Mark I
   Tashani, Osama A
   Bagnall, Anne-Marie
TI Acupuncture for cancer pain in adults.
SO The Cochrane database of systematic reviews
LA English
DT Journal Article
AB BACKGROUND: Forty per cent of individuals with early or intermediate stage cancer 
   and 90% with advanced cancer have moderate to severe pain and up to 70% of 
   patients with cancer pain do not receive adequate pain relief. It has been 
   claimed that acupuncture has a role in management of cancer pain and guidelines 
   exist for treatment of cancer pain with acupuncture. This is an updated version 
   of a Cochrane Review published in Issue 1, 2011, on acupuncture for cancer pain 
   in adults. OBJECTIVES: To evaluate efficacy of acupuncture for relief of 
   cancer-related pain in adults. SEARCH METHODS: For this update CENTRAL, MEDLINE, 
   EMBASE, PsycINFO, AMED, and SPORTDiscus were searched up to July 2015 including 
   non-English language papers. SELECTION CRITERIA: Randomised controlled trials 
   (RCTs) that evaluated any type of invasive acupuncture for pain directly related 
   to cancer in adults aged 18 years or over. DATA COLLECTION AND ANALYSIS: We 
   planned to pool data to provide an overall measure of effect and to calculate the 
   number needed to treat to benefit, but this was not possible due to 
   heterogeneity. Two review authors (CP, OT) independently extracted data adding it 
   to data extraction sheets. Data sheets were compared and discussed with a third 
   review author (MJ) who acted as arbiter. Data analysis was conducted by CP, OT 
   and MJ. MAIN RESULTS: We included five RCTs (285 participants). Three studies 
   were included in the original review and two more in the update. The authors of 
   the included studies reported benefits of acupuncture in managing pancreatic 
   cancer pain; no difference between real and sham electroacupuncture for pain 
   associated with ovarian cancer; benefits of acupuncture over conventional 
   medication for late stage unspecified cancer; benefits for auricular (ear) 
   acupuncture over placebo for chronic neuropathic pain related to cancer; and no 
   differences between conventional analgesia and acupuncture within the first 10 
   days of treatment for stomach carcinoma. All studies had a high risk of bias from 
   inadequate sample size and a low risk of bias associated with random sequence 
   generation. Only three studies had low risk of bias associated with incomplete 
   outcome data, while two studies had low risk of bias associated with allocation 
   concealment and one study had low risk of bias associated with inadequate 
   blinding. The heterogeneity of methodologies, cancer populations and techniques 
   used in the included studies precluded pooling of data and therefore 
   meta-analysis was not carried out. A subgroup analysis on acupuncture for 
   cancer-induced bone pain was not conducted because none of the studies made any 
   reference to bone pain. Studies either reported that there were no adverse events 
   as a result of treatment, or did not report adverse events at all. AUTHORS' 
   CONCLUSIONS: There is insufficient evidence to judge whether acupuncture is 
   effective in treating cancer pain in adults.
C1 Research & Development Department, Airedale NHS Foundation Trust, Airedale General Hospital, Steeton, Keighley, West Yorkshire, UK, BD20 6TD.
NR 0
TC 0
SN 1469-493
EI 
J9 Cochrane Database Syst Rev
PD OCT 16
PY 2015
VL 2015
IS 10
BP CD007753
EP CD007753
DI 10.1002/14651858.CD007753.pub3 
PG 1
WC Acupuncture Therapy; methods; Acupuncture, Ear; methods; Adult; Humans; Neoplasms; complications; Pain; etiology; Pain Management; methods; Pain Measurement; Randomized Controlled Trials as Topic
UT PubMed:26468973
PM 26468973
DA 2015-10-16
ER

PT J
AU Li, QY
   Yang, WX
   Liu, H
   Jiao, LJ
   Gong, YB
   Shi, J
AF Li, Quan-Yao
   Yang, Wen-Xiao
   Liu, Hui
   Jiao, Li-Jing
   Gong, Ya-Bin
   Shi, Jun
TI Research on Electroacupuncture Parameters for Cancer Pain Based on Data Mining.
SO Integrative cancer therapies
LA English
DT Review
DE cancer pain; data mining; electroacupuncture; parameter; traditional Chinese medicine
AB BACKGROUND: Cancer pain, a common complication of this disease, has been widely 
   treated by electroacupuncture in recent years. However, there are numerous 
   treatment parameters that are not conducive to clinical translation applications. 
   This study aims to summarize the stimulation parameters commonly used in 
   electroacupuncture treating cancer pain by data mining and visualization 
   techniques to provide a basis for the future acupuncture technology 
   transformation and selection of optimal stimulation parameters. METHODS: Nine 
   databases, including Pubmed, Cochrane Library, Embase, Web of Science, OVID, 
   China National Knowledge Infrastructure Database, China Biology Medicine disk, 
   China Science and Technology Journal Database, and Wanfang Database, were 
   searched for clinical studies on electroacupuncture treatment cancer pain 
   published between January 2012 and September 2022. A database was established 
   using Microsoft Excel 2020 and analyzed with SPSS Modeler 18.1 software and SPSS 
   statistics 26.0 software. RESULTS: Twenty-four articles were included according 
   to the established criteria. The most used electroacupuncture stimulation 
   parameters were a dilatational wave, the current frequency of 2/100 Hz, 
   stimulation duration of 30 minutes per treatment, and frequency of treatment once 
   a day. Fifty-eight acupoints were mentioned, and the total frequency of acupoints 
   involved was 156 times. The most used ones include Zusanli (ST36), Sanyinjiao 
   (SP06), Hegu (LI04), Neiguan (PC06), Quchi (LI11), Taichong (LR03), Ashi point, 
   Jiaji point, and those most generally used acupoints that are closely arranged on 
   the Stomach Channel of Foot Yangming and the Spleen Channel of Foot Taiyin. The 
   association analysis of acupoints revealed that the most supported acupoint pair 
   was Sanyinjiao (SP06) and Zusanli (ST36). Cluster analysis demonstrated 3 groups, 
   1 for obligatory acupoints, 1 for Ashi point, and the third for Jiaji point. 
   CONCLUSIONS: A dilatational wave, the current frequency of 2/100 Hz, 30-minute 
   stimulation, and acupoints of the Stomach Channel of Foot Yangming and the Spleen 
   Channel of Foot Taiyin selection are frequently used in electroacupuncture for 
   treating cancer pain. Due to the limitations of this study, further research and 
   more standardized, multi-center, large-sample clinical trials can be carried out 
   to guide optimizing acupuncture treatment schemes and promote the formation of 
   TCM-characteristic technologies for cancer pain.
C1 Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional ChineseMedicine, Shanghai, China.
   Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional ChineseMedicine, Shanghai, China.
   Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional ChineseMedicine, Shanghai, China.
   Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional ChineseMedicine, Shanghai, China.
   Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional ChineseMedicine, Shanghai, China.
   Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional ChineseMedicine, Shanghai, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD AUG 8
PY 2023
VL 22
IS 
BP 15347354231192017
EP 15347354231192017
DI 10.1177/15347354231192017 
PG 1
WC Humans; Electroacupuncture; Meridians; Cancer Pain; therapy; Acupuncture Therapy; Data Mining; Neoplasms; complications
UT PubMed:37551854
PM 37551854
DA 2023-08-08
ER

PT J
AU Martini, RS
   Brown, T
   Singh, V
   Woodbury, A
AF Martini, Reema Sabeeha
   Brown, Terrell
   Singh, Vinita
   Woodbury, Anna
TI Integrative Approaches for Cancer Pain Management.
SO Current oncology reports
LA English
DT Review
DE Acupuncture; Alternative; Cancer pain; Complementary; Integrative; Yoga
AB PURPOSE OF REVIEW: The goal of this review is to summarize updates to the broad 
   array of complementary therapies available for cancer pain. This paper will serve 
   as a reference for clinicians managing pain in cancer patients. RECENT FINDINGS: 
   Patients are embracing integrative therapies in growing numbers; clinicians must 
   be prepared to incorporate these therapies into patients' existing treatment 
   regimens. This requires knowledge regarding risks, benefits, and potential 
   interactions with existing cancer therapies. Integrative cancer pain management 
   strategies have shown promise, with several proven effective for the management 
   of cancer pain. Energy therapies, including acupuncture, and biologicals and 
   nutraceuticals including overall diet and vitamin D, have the highest level of 
   evidence for efficacy. The remaining therapies discussed in this chapter may be 
   beneficial for patients on a case-by-case basis; risks and benefits of each 
   individual therapy as described in the text must be further assessed in future 
   rigorous trials to further clarify the role of these complementary therapies in 
   cancer pain management.
C1 Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA. reema.martini@emory.edu.
   Emory University Laney Graduate School, Atlanta, GA, USA. 
   Morehouse School of Medicine, Atlanta, GA, USA.
   Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA.
   Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA.
   Atlanta Veterans Affairs Healthcare System, Atlanta, GA, USA.
NR 0
TC 0
SN 1534-626
EI 1523-379
J9 Curr Oncol Rep
PD APR 29
PY 2024
VL 26
IS 6
BP 691
EP 705
DI 10.1007/s11912-024-01536-3 
PG 14
WC Humans; Cancer Pain; therapy; Pain Management; methods; Complementary Therapies; methods; Neoplasms; complications; Integrative Medicine; methods
UT PubMed:38683254
PM 38683254
DA 2024-04-29
ER

PT J
AU Qi, QL
   Han, X
   Tang, C
AF Qi, Qing-Ling
   Han, Xue
   Tang, Cheng
TI Effects of Acupuncture on Breast Cancer Patients Taking Aromatase Inhibitors.
SO BioMed research international
LA English
DT Journal Article
AB Although acupuncture has been used in clinical practice for thousands of years, 
   it remains a controversial treatment option to help alleviate pain in cancer 
   patients. In this study, we analyzed published material on randomized trials of 
   acupuncture from MEDLINE published up until July 31, 2018, to assess its effects 
   on pain experienced by cancer patients. Revman 5.0 software was used to conduct 
   meta-analysis with pain score as the index. The results of nine randomized 
   controlled trials involving 592 patients were analyzed and showed that 
   acupuncture can relieve the pain caused by aromatase inhibitors. Weighted mean 
   difference of worst pain and pain severity was -3.03, 95% CI (-3.90,-2.16) and 
   -2.69, 95% CI (-4.08,-1.30), respectively (P < 0.01). This led us to conclude 
   that acupuncture has pain relieving effects against pain caused by aromatase 
   inhibitors.
C1 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture andMoxibustion, 300381 Tianjin, China.
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture andMoxibustion, 300381 Tianjin, China.
   School of Pharmacy, Tianjin Medical University, 300070 Tianjin, China.
NR 0
TC 0
SN 2314-614
EI 2314-613
J9 Biomed Res Int
PD SEP 23
PY 2022
VL 2022
IS 
BP 1164355
EP 1164355
DI 10.1155/2022/1164355 
PG 0
WC Acupuncture; Acupuncture Therapy; methods; Aromatase Inhibitors; adverse effects; Breast Neoplasms; chemically induced; Female; Humans; Pain; drug therapy; Randomized Controlled Trials as Topic
UT PubMed:36132087
PM 36132087
DA 2022-09-23
ER

PT J
AU Yang, R
   Zhang, YX
   Zhang, CC
   Yan, QF
   Han, L
AF Yang, Rui
   Zhang, Yi-Xuan
   Zhang, Chun-Chang
   Yan, Qin-Feng
   Han, Lin
TI Acupuncture and moxibustion treatment for breast cancer-related lymphoedema： a 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acupuncture; Breast cancer-related lymphedema; Meta-analysis; Randomized controlled trials; Systematic review
AB OBJECTIVES: To evaluate the efficacy of acupuncture in treating breast 
   cancer-related lymphedema (BCRL) by using systematic review and Meta analysis 
   method. METHODS: Searching CNKI, Wanfang Data Knowledge Service Platform, VIP 
   Chinese Journal Service Platform, Chinese Biomedical Literature Database, PubMed, 
   Cochrane Library, Embase and Web of Science, the randomized controlled trials 
   (RCTs) literature of acupuncture for BCRL was collected from the establishment of 
   the databases to October 1(st), 2023. After data extraction and risk of bias 
   evaluation of the included literature, Meta-analysis was performed using 
   RevMan5.4 software. RESULTS: A total of 14 RCTs with 952 patients were included. 
   The Meta-analysis results showed that compared with comprehensive decongestive 
   therapy (CDT), CDT-associated methods and other interventions of the contro 
   group, acupuncture was able to decrease the circumference of the proximal 10 cm 
   to elbow crease (MD=-1.95, P=0.000 5), reduce the difference in arm circumference 
   (MD=-1.30, P<0.000 01), and increase the effective index (MD=27.47, P<0.000 
   01；RR=1.23, P=0.000 5)；acupuncture improves the range of motion(ROM) scores of 
   shoulder joint in four areas：anteflexion(SMD=0.47, P=0.04), posterior extension 
   (SMD=0.87, P<0.000 01), abduction (SMD=0.48, P=0.03), and adduction (SMD=0.72, 
   P=0.000 5)；acupuncture also could alleviate pain and improve visual analog scale 
   (VAS) scores (MD=-1.15, P<0.000 01). No serious adverse reactions were reported 
   in the literatures. CONCLUSIONS: Acupuncture can effectively improve the degree 
   of limb edema and subjective symptoms in BCRL patients.
C1 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   Tianjin University of Traditional Chinese Medicine, Tianjin 301617.
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   Tianjin University of Traditional Chinese Medicine, Tianjin 301617.
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   Tianjin University of Traditional Chinese Medicine, Tianjin 301617.
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   Tianjin University of Traditional Chinese Medicine, Tianjin 301617.
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China. tjhanlin@163.com.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUL 18
PY 2024
VL 49
IS 7
BP 715
EP 725
DI 10.13702/j.1000-0607.20230903 
PG 10
WC Humans; Moxibustion; Acupuncture Therapy; Female; Breast Cancer Lymphedema; therapy; Randomized Controlled Trials as Topic; Breast Neoplasms; therapy; Treatment Outcome; Acupuncture Points; Lymphedema; therapy
UT PubMed:39020490
PM 39020490
DA 2024-07-18
ER

PT J
AU Liang, Q
   Zhang, K
   Wang, S
   Xu, X
   Liu, Y
   Cui, S
   Liu, L
AF Liang, Qi
   Zhang, Ke
   Wang, Sumeng
   Xu, Xian
   Liu, Yiqian
   Cui, Shiyun
   Liu, Lingxiang
TI Acupuncture for Cancer Pain - An Adjuvant Therapy for Cancer Pain Relief.
SO The American journal of Chinese medicine
LA English
DT Review
DE Acupuncture; Cancer Pain; Pain Management; Review
AB As current pain management methods cannot effectively control pain among cancer 
   patients, acupuncture has developed as an adjuvant therapy for cancer pain 
   relief. However, the efficacy of acupuncture in treating cancer pain remains 
   controversial. Here, we briefly introduced the development of pain management, 
   analgesic mechanisms, and acupuncture methods. Meanwhile, a comprehensive 
   overview of acupuncture programs was provided in terms of different cancer types, 
   sources, and degrees. Interestingly, acupuncture can treat both tumor-induced 
   pain and therapy-induced pain well among cancer patients. We preliminarily 
   summarized frequently-used acupoints for different types of cancer pain and found 
   that needle retention time was mostly 30 min, and treatment cycle was two weeks. 
   Additionally, clinicians consistently selected Ashi acupoint or bilateral Zusanli 
   acupoint and combined multiple acupuncture methods for different degrees of 
   cancer pain.
C1 Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China.
   Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China.
   Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China.
   Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China.
   Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China.
   Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China.
   Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China.
NR 0
TC 0
SN 1793-685
EI 
J9 Am J Chin Med
PD DEC 11
PY 2020
VL 48
IS 8
BP 1769
EP 1786
DI 10.1142/S0192415X20500883 
PG 17
WC Female; Humans; Male; Acupuncture Analgesia; methods; Breast Neoplasms; complications; Cancer Pain; etiology; Combined Modality Therapy; Lung Neoplasms; complications; Pain, Postoperative; etiology; Stomach Neoplasms; complications; Neoplasms; complications
UT PubMed:33300479
PM 33300479
DA 2020-12-11
ER

PT J
AU Lu, W
   Rosenthal, DS
AF Lu, Weidong
   Rosenthal, David S
TI Oncology Acupuncture for Chronic Pain in Cancer Survivors: A Reflection on the 
SO Hematology/oncology clinics of North America
LA English
DT Review
DE ASCO practice guideline; Cancer survivors; Chronic pain; Oncology acupuncture
AB Chronic pain syndromes associated with cancer treatment are common but difficult 
   to manage. The American Society of Clinical Oncology recently published a 
   practice guideline to address the unmet needs of cancer survivors, Management of 
   Chronic Pain in Survivors of Adult Cancers, which stresses the importance of 
   implementing integrative therapies including acupuncture. This review focuses on 
   randomized clinical trials of acupuncture for chronic pain in cancer survivors, 
   including its use in chemotherapy-induced peripheral neuropathy, aromatase 
   inhibitor-associated arthralgia, and post neck dissection pain, and provides 
   future directions of oncology acupuncture research in cancer survivorship. The 
   features of oncology acupuncture are also discussed.
C1 Leonard P. Zakim Center for Integrative Therapies and Healthy Living, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215,USA. 
   Leonard P. Zakim Center for Integrative Therapies and Healthy Living, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215,USA.
EM weidong_lu@dfci.harvard.edu
NR 0
TC 0
SN 1558-197
EI 
J9 Hematol Oncol Clin North Am
PD MAY 8
PY 2018
VL 32
IS 3
BP 519
EP 533
DI 10.1016/j.hoc.2018.01.009 
PG 14
WC Acupuncture Analgesia; methods; Cancer Survivors; Chronic Pain; etiology; Humans; Medical Oncology; Neoplasms; pathology; Practice Guidelines as Topic; Societies, Medical; United States
UT PubMed:29729786
PM 29729786
DA 2018-05-08
ER

PT J
AU Paley, CA
   Johnson, MI
   Tashani, OA
   Bagnall, AM
AF Paley, Carole A
   Johnson, Mark I
   Tashani, Osama A
   Bagnall, Anne-Marie
TI Acupuncture for cancer pain in adults.
SO The Cochrane database of systematic reviews
LA English
DT Journal Article
AB BACKGROUND: Forty percent of individuals with early or intermediate stage cancer 
   and 90% with advanced cancer have moderate to severe pain and up to 70% of 
   patients with cancer pain do not receive adequate pain relief. It has been 
   claimed that acupuncture has a role in management of cancer pain and guidelines 
   exist for treatment of cancer pain with acupuncture. OBJECTIVES: To evaluate 
   efficacy of acupuncture for relief of cancer-related pain in adults. SEARCH 
   STRATEGY: CENTRAL, MEDLINE, EMBASE, PsycINFO, AMED, and SPORTDiscus were searched 
   up to November 2010 including non-English language papers. SELECTION CRITERIA: 
   Randomised controlled trials (RCTs) evaluating any type of invasive acupuncture 
   for pain directly related to cancer in adults of 18 years or over. DATA 
   COLLECTION AND ANALYSIS: It was planned to pool data to provide an overall 
   measure of effect and to calculate the number needed to treat to benefit, but 
   this was not possible due to heterogeneity. Two review authors (CP, OT) 
   independently extracted data adding it to data extraction sheets. Quality scores 
   were given to studies. Data sheets were compared and discussed with a third 
   review author (MJ) who acted as arbiter. Data analysis was conducted by CP, OT 
   and MJ. MAIN RESULTS: Three RCTs (204 participants) were included. One high 
   quality study investigated the effect of auricular acupuncture compared with 
   auricular acupuncture at 'placebo' points and with non-invasive vaccaria ear 
   seeds attached at 'placebo' points. Participants in two acupuncture groups were 
   blinded but blinding wasn't possible in the ear seeds group because seeds were 
   attached using tape. This may have biased results in favour of acupuncture 
   groups. Participants in the real acupuncture group had lower pain scores at two 
   month follow-up than either the placebo or ear seeds group.There was high risk of 
   bias in two studies because of low methodological quality. One study comparing 
   acupuncture with medication concluded that both methods were effective in 
   controlling pain, although acupuncture was the most effective. The second study 
   compared acupuncture, point-injection and medication in participants with stomach 
   cancer. Long-term pain relief was reported for both acupuncture and 
   point-injection compared with medication during the last 10 days of treatment. 
   Although both studies have positive results in favour of acupuncture they should 
   be viewed with caution due to methodological limitations, small sample sizes, 
   poor reporting and inadequate analysis. AUTHORS' CONCLUSIONS: There is 
   insufficient evidence to judge whether acupuncture is effective in treating 
   cancer pain in adults.
C1 Research and Effectiveness Department, Airedale NHS Trust, Airedale General Hospital, Steeton, Keighley, West Yorkshire, UK, BD20 6TD.
NR 0
TC 0
SN 1469-493
EI 
J9 Cochrane Database Syst Rev
PD JAN 21
PY 2011
VL 0
IS 1
BP CD007753
EP CD007753
DI 10.1002/14651858.CD007753.pub2 
PG 1
WC Acupuncture Therapy; methods; Acupuncture, Ear; methods; Adult; Humans; Neoplasms; complications; Pain; etiology; Pain Management; Pain Measurement; Randomized Controlled Trials as Topic
UT PubMed:21249694
PM 21249694
DA 2011-01-21
ER

PT J
AU Yao, Z
   Xu, Z
   Xu, T
   Liu, X
   Xu, S
   Wan, C
   Zhou, X
AF Yao, Ziqian
   Xu, Zhongbo
   Xu, Tielong
   Liu, Xiaowu
   Xu, Sheng
   Wan, Chanjun
   Zhou, Xu
TI Moxibustion for alleviating chemotherapy-induced gastrointestinal adverse 
SO Complementary therapies in clinical practice
LA English
DT Journal Article
DE Chemotherapy; Gastrointestinal adverse effects; Malignant tumours; Moxibustion; Systematic review
AB OBJECTIVE: This systematic review aims to assess whether moxibustion is effective 
   and safe for gastrointestinal adverse effects, a common and thorny issue arising 
   from chemotherapy. METHODS: Seven electronic databases were searched up to August 
   28, 2021, to identify randomized controlled trials (RCTs) comparing moxibustion 
   versus non-moxibustion treatments for various gastrointestinal adverse effects 
   after chemotherapy. The Karnofsky performance status (KPS) and quality of life 
   scores and the incidence of moxibustion-related adverse events were also 
   investigated. Effects in meta-analyses were measured by risk ratios (RRs) or mean 
   differences (MDs). RESULTS: Thirty-two RCTs (n = 2990) were included. Compared to 
   the controls, moxibustion significantly reduced the incidences of nausea/vomiting 
   (RR 0.70, 95% CI 0.61-0.79), severe nausea/vomiting (RR 0.39, 95% CI 0.29-0.51), 
   diarrhoea (RR 0.56, 95% CI 0.38-0.82), constipation (RR 0.59, 95% CI 0.44-0.78), 
   and abdominal distension (RR 0.60, 95% CI 0.46-0.78). The KPS (MD 7.53, 95% CI 
   3.42-11.64) and quality of life (MD 8.88, 95% CI 0.96-16.80) scores were also 
   significantly improved after moxibustion. The results did not support a benefit 
   of moxibustion on inappetence (RR 0.69, 95% CI 0.40-1.22) or abdominal pain (RR 
   0.60, 95% CI 0.28-1.30). All adverse events related to moxibustion were mild. 
   CONCLUSIONS: Moderate-to very-low-quality evidence suggests that moxibustion may 
   be safely used as an adjuvant treatment after chemotherapy to reduce the 
   incidences of nausea and vomiting, diarrhoea, constipation, and abdominal 
   distension and improve the performance status and quality of life in patients 
   with malignant tumours. Its effects on abdominal pain and inappetence are 
   uncertain.
C1 Evidence-based Medicine Research Centre, Jiangxi University of Chinese Medicine, Nanchang, China. 
   Department of Emergency, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China. 
   Evidence-based Medicine Research Centre, Jiangxi University of Chinese Medicine, Nanchang, China. 
   Evidence-based Medicine Research Centre, Jiangxi University of Chinese Medicine, Nanchang, China. 
   Evidence-based Medicine Research Centre, Jiangxi University of Chinese Medicine, Nanchang, China. 
   Department of Cardiology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China. 
   Evidence-based Medicine Research Centre, Jiangxi University of Chinese Medicine, Nanchang, China. 
EM zhouxu_ebm@hotmail.com
NR 0
TC 0
SN 1873-694
EI 
J9 Complement Ther Clin Pract
PD JAN 10
PY 2022
VL 46
IS 
BP 101527
EP 101527
DI 10.1016/j.ctcp.2021.101527 
PG 0
WC Antineoplastic Agents; adverse effects; Humans; Moxibustion; Nausea; chemically induced; Randomized Controlled Trials as Topic; Vomiting; chemically induced
UT PubMed:34999499
PM 34999499
DA 2022-01-10
ER

PT J
AU Cheng, HB
AF Cheng, Hai-Bo
TI Clinical practice of acupuncture and moxibustion in treatment of tumor-related 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Review
DE Acupuncture-moxibustion; Clinical practice; Tumor-related syndrome
AB Tumor and its concomitant symptoms such as pain, fatigue and nausea bring a huge 
   physical and mental burden to the patients. Although the medication is a common 
   intervention for these symptoms, these problems have not been solved yet due to 
   the side effects and patients' tolerance. In modern clinical practice of 
   anti-tumor, acupuncture-moxibustion not only inhibits the growth of tumor, but 
   also ameliorates the related symptoms as an auxiliary therapy. The paper 
   summarizes the application of acupuncture-moxibustion in treatment of malignant 
   tumor and its related symptoms, systematizes the therapeutic effects on the 
   common symptoms and analyzes the clinical value of acupuncture-moxibustion for 
   anti-tumor.
C1 Key Laboratory of Acupuncture and Herbal Medicine of the Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.haibocheng@njucm.edu.cn.
   The First School of Clinical Medicine, Nanjing 210023. haibocheng@njucm.edu.cn.
   Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, Nanjing 210023. haibocheng@njucm.edu.cn.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUL 18
PY 2024
VL 49
IS 7
BP 693
EP 699
DI 10.13702/j.1000-0607.20230985 
PG 6
WC Humans; Moxibustion; Acupuncture Therapy; Neoplasms; therapy
UT PubMed:39020487
PM 39020487
DA 2024-07-18
ER

PT J
AU Chien, TJ
   Liu, CY
   Chang, YF
   Fang, CJ
   Hsu, CH
AF Chien, Tsai-Ju
   Liu, Chia-Yu
   Chang, Yi-Fang
   Fang, Ching-Ju
   Hsu, Chung-Hua
TI Acupuncture for treating aromatase inhibitor-related arthralgia in breast cancer: 
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
AB PURPOSE: Acupuncture has been used as a complementary medical treatment for 
   arthralgia and other types of pain. The objective of this review is to assess the 
   effectiveness of acupuncture in the treatment of arthralgia in patients with 
   breast cancer who were treated with aromatase inhibitors (AIs). METHODS: A 
   literature search was performed, without language restrictions, of 10 databases 
   from their inception through February 2014. The literature reviewed included 
   randomized clinical trials (RCTs) and clinical trials that compared real versus 
   sham acupuncture for the treatment of AI-related musculoskeletal symptoms 
   (AIMSS). The methodologic quality of these trials was assessed by using the 
   modified Jadad Quality Scale. Meta-analytic software (RevMan 5.0) was used to 
   analyze the data. RESULTS: Five To compare the effects of real versus sham 
   acupuncture, five RCTs were assessed by meta-analysis and quality analysis. Three 
   of the RCTs reported favorable effects with regard to use of acupuncture in 
   reducing pain and joint-related symptoms, while the other two RCTs did not. The 
   meta-analysis showed trends toward reduced pain and stiffness in patients given 
   acupuncture compared with those who received sham treatment (n=82; pain, mean 
   difference: -2.07 [95% confidence interval (CI), -4.72 to 0.57]; p=0.12; 
   stiffness, mean difference: -86.10 [95% CI, -249.11 to 76.92]; p=0.30), although 
   these differences were not statistically significant. CONCLUSIONS: Acupuncture 
   has been reported as a safe and promising treatment for AIMSS, but the present 
   analysis indicated that the effects were not statistically significant. Other 
   outcome measurements, such as imaging studies, would be worth including in future 
   studies to further confirm the efficacy of acupuncture in AIMSS.
C1 1 Institute of Traditional Medicine, National Yang-Ming University , Taipei, Taiwan .
NR 0
TC 0
SN 1557-770
EI 1075-553
J9 J Altern Complement Med
PD APR 29
PY 2015
VL 21
IS 5
BP 251
EP 60
DI 10.1089/acm.2014.0083 
PG -191
WC Acupuncture Therapy; methods; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Female; Humans
UT PubMed:25915433
PM 25915433
DA 2015-04-29
ER

PT J
AU Van, de Castle B
   Lukkahatai, N
   Billing, BL
   Huang, X
   Wu, H
   Zhang, J
   Abdi, S
   Kameoka, J
   Smith, TJ
AF Van de Castle, Barb
   Lukkahatai, Nada
   Billing, Bsn Lynn
   Huang, Xinran
   Wu, Hulin
   Zhang, Jingyu
   Abdi, Salahadin
   Kameoka, Jun
   Smith, Thomas J
TI Nurse-Administered Auricular Point Acupressure for Cancer-Related Pain.
SO Integrative cancer therapies
LA English
DT Journal Article
DE auricular acupressure; cancer; cancer-related-pain; nursing; pain
AB PURPOSE: The study aimed to (1) examine the feasibility of providing a training 
   course on auricular point acupressure (APA) for clinical oncology nurses to 
   integrate APA into real-world nursing care settings, and (2) examine the 
   effectiveness of APA on cancer-related pain (CRP) under usual inpatient oncology 
   ward conditions. METHODS: This was a 2-phase feasibility study. Phase 1, an 
   in-person, 8 hour training program was provided to oncology nurses. Phase 2, a 
   prospective and feasibility study was conducted to evaluate the integration of 
   APA into nursing care activities to manage CRP. Oncology patients were included 
   if their pain was rated at ≥4 on a 0 to 10 numeric rating scale in the past 
   24 hours. Patients received 1 APA treatment administered by the nurses and were 
   instructed to stimulate the points for 3 days. Study outcomes (pain intensity, 
   fatigue, and sleep disturbance), pain medication use, and APA practice were 
   measured by a phone survey daily. RESULTS: Ten oncology nurses received APA 
   training in phase 1. APA had been added to the hospital's electronic health 
   records (EHRs) as a pain treatment. In phase 2, 33 oncology patients received APA 
   treatment with a 100% adherence rate (pressing the seeds 3 times per day, 
   3 minutes per time based on the suggestion). The side effects of APA were minimal 
   (~8%-12% felt tenderness on the ear). After 3 days of APA, patients reported 38% 
   pain relief, 39% less fatigue, and 45% improvement in sleep disturbance; 24% 
   reduced any type of pain medication use and 19% reduced opioid use (10 mg opioids 
   using milligram morphine equivalent). The major barrier to integrating APA into 
   routine nursing practice was time management (how to include APA in a daily 
   workflow). CONCLUSION: It is feasible to provide 8-hour training to oncology 
   nurses for mastering APA skill and then integrating APA into their daily nursing 
   care for patients with CRP. Based on the promising findings (decreased pain, 
   improved fatigue and sleep disturbance, and less opioid use), the next step is to 
   conduct a randomized clinical trial with a larger sample to confirm the efficacy 
   of APA for oncology nurses to treat CRP in real-world practice.ClinicalTrial.gov 
   identifier number: NCT04040140.
C1 University of Maryland School of Nursing, Baltimore, MD, USA.
   Johns Hopkins University School of Nursing, Baltimore, MD, USA.
   Johns Hopkins Hospital, Baltimore, MD, USA.
   The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
   The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
   Johns Hopkins University School of Nursing, Baltimore, MD, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   Waseda University, Tokyo, Japan.
   Johns Hopkins University School of Medicine, Baltimore, MD, USA.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD SEP 14
PY 2023
VL 22
IS 
BP 15347354231198086
EP 15347354231198086
DI 10.1177/15347354231198086 
PG 1
WC Humans; Acupressure; Analgesics, Opioid; Cancer Pain; therapy; Fatigue; Feasibility Studies; Neoplasms; complications; Prospective Studies; Treatment Outcome
UT PubMed:37706457
PM 37706457
DA 2023-09-14
ER

PT J
AU Han, KH
   Cho, KH
   Han, C
   Cui, S
   Lin, L
   Baek, HY
   Kim, J
AF Han, Kyou-Hwan
   Cho, Ki Haeng
   Han, Caroline
   Cui, Shanqin
   Lin, Lily
   Baek, Ho-Yu
   Kim, Jaejong
TI The effectiveness and safety of acupuncture treatment on sciatica: A systematic 
SO Complementary therapies in medicine
LA English
DT Journal Article
DE A systematic review and meta-analysis; Acupuncture treatment; Analgesic; Randomized controlled trial; Sciatica
AB BACKGROUND: Sciatica results from primary or secondary damage to the sciatic 
   nerve in the lumbar or gluteal region. The first option for sciatica is 
   analgesics, but their therapeutic effect and safety in long-term use are 
   questionable. On the other hand, acupuncture has recently been recognized as a 
   complementary and alternative medicine (CAM) to conventional medicine, and 
   studies on its effectiveness and safety have been actively conducted. OBJECTIVE: 
   To systematically compare acupuncture with analgesics in terms of effect, safety, 
   and durability in the treatment of sciatica METHODS: This review was performed in 
   accordance with Cochrane Handbook for Systematic Reviews of Interventions Version 
   6.2. Four databases were searched for this review: Wangfang, the Korean 
   Traditional Knowledge Portal (KTKP), PubMed, and EBSCOhost. The primary outcome 
   measures in the review were total effective rate (TER), visual analog scale (VAS) 
   score and pain threshold, and the secondary ones were adverse effects (AEs) and 
   relapse rates. Risk ratio (RR) for TER and mean difference (MD) for VAS score and 
   pain threshold were used as statistics for the meta-analysis of effectiveness, 
   along with associated 95 % confidence intervals (CIs) and P-values. AEs and 
   relapse rates were used for the safety and durability of the interventions. 
   Version 2 of the Cochrane risk-of-bias assessment tool for randomized trials (RoB 
   2) was used for the methodological quality of randomized controlled trials (RCTs) 
   included in the review. RESULTS: The synthesized TER of 28 RCTs involving 2707 
   participants was significantly higher in the acupuncture group compared to the 
   analgesic group (RR [95 % CI] = 1.20 [1.16, 1.24], P < 0.001). The synthesized 
   VAS score of 7 RCTs involving 589 participants was significantly reduced in the 
   acupuncture group compared to the analgesic group (MD [95 % CI] = - 1.78 [- 2.44, 
   - 1.12], P < 0.001). In 5 RCTs involving 311 participants, the synthesized pain 
   threshold was significantly elevated in the acupuncture group compared to the 
   analgesic group (MD [95 % CI] = 0.93 [0.64, 1.22], P < 0.001). Additionally, 
   adverse effects (AEs) and relapse rates of RCTs in the review were lower in the 
   acupuncture group compared to the analgesic group. CONCLUSION: In this systematic 
   review, acupuncture treatment was significantly effective and safe compared to 
   analgesics in sciatica. In the future, studies with a rigorous study design are 
   required to increase the validity of the effectiveness and safety of acupuncture 
   treatment for sciatica.
C1 SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 6th Street, Los Angeles, CA 90057, USA. 
   SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 6th Street, Los Angeles, CA 90057, USA.
   SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 6th Street, Los Angeles, CA 90057, USA.
   SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 6th Street, Los Angeles, CA 90057, USA.
   SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 6th Street, Los Angeles, CA 90057, USA.
   School of Big Data and Financial Statistics, Wonkwang University, 460 Iksandaero, Iksan, Jeonbuk 54538, the Republic of Korea.
   SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 6th Street, Los Angeles, CA 90057, USA.
EM youhwan2013@gmail.com
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD AUG 20
PY 2022
VL 71
IS 
BP 102872
EP 102872
DI 10.1016/j.ctim.2022.102872 
PG 0
WC Humans; Neoplasm Recurrence, Local; drug therapy; Acupuncture Therapy; adverse effects; Analgesics; therapeutic use; Complementary Therapies; Sciatica; therapy
UT PubMed:35985442
PM 35985442
DA 2022-08-20
ER

PT J
AU Zhang, D
   Ji, Y
   Lv, L
   Zhou, Q
   Liu, Z
   Zhang, C
   Chen, S
AF Zhang, Di
   Ji, Yue
   Lv, Liu
   Zhou, Qiongyang
   Liu, Zhijiang
   Zhang, Chenlin
   Chen, Shanshan
TI An Overview of Systematic Reviews and Meta-Analyses of Clinical Studies of 
SO Integrative cancer therapies
LA English
DT Review
DE acupuncture; cancer; evidence; overview; pain
AB BACKGROUND: Systematic reviews (SRs) and meta-analyses (MAs) for the use of 
   acupuncture for cancer pain have been increasing, but the evidence has not been 
   systematically and comprehensively assessed. We aimed to perform an overview of 
   the evidence quality of SRs/MAs of acupuncture for improving cancer pain. 
   METHODS: 8 databases were systematically searched to identify SRs/MAs of 
   acupuncture for improving cancer pain. The A Measurement Tool to Assess 
   Systematic Reviews 2 (AMSTAR-2), Risk of Bias in Systematic Reviews (ROBIS), 
   Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and 
   Grades of Recommendations, Assessment, Development, and Evaluation (GRADE), 
   respectively, were applied by 2 independent reviewers to evaluate the 
   methodological quality, risk of bias, reporting quality, and evidence quality. 
   RESULTS: A total of 14 SRs/MAs were included in the present study. By AMSTAR-2, 
   two reviews were rated as having high methodological quality, while 12 were given 
   a critically low rating. All SRs/MAs in Phase 1, Domain 1, and Domain 4, 
   according to ROBIS, were at low risk. Furthermore, 4 reviews in Domain 2, twelve 
   reviews in Domain 3, and ten SRs/MAs in Phase 3, were rated as having low risk of 
   bias. With reporting quality, some reporting flaws were identified in the topic 
   of protocol and registration, additional analyses, and search strategy. According 
   to GRADE, the level of evidence quality was "critically low" to "moderate," and 
   risk of bias was the most common downgraded factor. CONCLUSION: Acupuncture may 
   be beneficial in improving cancer pain. However, due to the identified 
   limitations and inconsistent findings, we recommend further rigorous, and more 
   standardized SRs/MAs to provide strong evidence for definitive conclusions.
C1 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
   Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   The First People's Hospital of Wenling, Wenling, China.
   Gushi County Hospital of TCM, Gushi, China.
   Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Gansu Provincial Hospital of TCM, Lanzhou, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD NOV 9
PY 2023
VL 22
IS 
BP 15347354231210288
EP 15347354231210288
DI 10.1177/15347354231210288 
PG 1
WC Humans; Acupuncture Therapy; Cancer Pain; therapy; Databases, Factual; Neoplasms; complications; Systematic Reviews as Topic; Meta-Analysis as Topic
UT PubMed:37942632
PM 37942632
DA 2023-11-09
ER

PT J
AU Shi, Z
   Sun, H
   Wu, J
   Jin, Y
   Cao, S
   Cai, J
AF Shi, Zhengqin
   Sun, Hong
   Wu, Junlei
   Jin, Yude
   Cao, Sujie
   Cai, Jianli
TI Chinese acupoint therapies in cancer pain management: research advances and 
SO Pain management
LA English
DT Review
DE Cancer pain; acupuncture; analgesic therapies; electroacupuncture; moxibustion; traditional Chinese medicine
AB Cancer pain management (CPM) is crucial in oncology care, with current approaches 
   including pharmacotherapy, radiotherapy, chemotherapy, nerve blocks, and 
   psychological support. However, long-term drug use risks adverse effects and 
   addiction, while physiotherapies often lack sustained efficacy. Therefore, 
   identifying safer adjuvant analgesic therapies has become an urgent issue. 
   Traditional Chinese Medicine (TCM) acupoint therapies (acupuncture, moxibustion, 
   and acupoint injection) offer safer adjuvant analgesia with growing clinical 
   validation. This narrative review aims to introduce the research progress of 
   acupoint therapy in alleviating cancer pain and the role of emerging technologies 
   in advancing acupoint therapy. All literature selections were sourced exclusively 
   from PubMed and CNKI databases. First, we briefly introduce the mechanisms of 
   cancer pain, outline relevant evaluation methods, and summarize the limitations 
   of existing CPM strategies. Additionally, we discuss the therapeutic effects, 
   underlying mechanisms, and potential improvements of acupoint therapies in CPM. 
   Notably, recent advancements in information technology, artificial intelligence, 
   and materials science, along with the development of noninvasive stimulation 
   methods and innovative devices, have significantly advanced the understanding of 
   acupoint treatment mechanisms and expanded their clinical applications. Finally, 
   we highlight the challenges and future directions for TCM acupoint therapies. 
   This study provides clinical insights and recommendations for CPM.
C1 Department of Thyroid and Breast Minimally Invasive Surgery, Huzhou First People's Hospital, Huzhou, China.
   Department of General Surgery, Huzhou First People's Hospital, Huzhou, China.
   Department of Thyroid and Breast Minimally Invasive Surgery, Huzhou First People's Hospital, Huzhou, China.
   Department of General Surgery, Huzhou First People's Hospital, Huzhou, China.
   Department of Information Technology, Huzhou First People's Hospital, Huzhou, China.
   Nursing Department, Huzhou First People's Hospital, Huzhou, China.
NR 0
TC 0
SN 1758-187
EI 1758-186
J9 Pain Manag
PD MAY 22
PY 2025
VL 15
IS 6
BP 345
EP 358
DI 10.1080/17581869.2025.2510191 
PG 13
WC Humans; Cancer Pain; therapy; Acupuncture Points; Pain Management; methods; Medicine, Chinese Traditional; methods; Acupuncture Therapy; methods
UT PubMed:40402471
PM 40402471
DA 2025-05-22
ER

PT J
AU Yeh, CH
   Lukkahatai, N
   Huang, X
   Wu, H
   Wang, H
   Zhang, J
   Sun, X
   Smith, TJ
AF Yeh, Chao Hsing
   Lukkahatai, Nada
   Huang, Xinran
   Wu, Hulin
   Wang, Hongyu
   Zhang, Jingyu
   Sun, Xinyi
   Smith, Thomas J
TI Biological Correlates of the Effects of Auricular Point Acupressure on Pain.
SO Pain management nursing : official journal of the American Society of Pain 
LA English
DT Journal Article
DE Auricular point acupressure; Chemokines; Cytokines; Inflammatory biomarkers; Self-management
AB BACKGROUND: To identify candidate inflammatory biomarkers for the underlying 
   mechanism of auricular point acupressure (APA) on pain relief and examine the 
   correlations among pain intensity, interference, and inflammatory biomarkers. 
   DESIGN: This is a secondary data analysis. METHODS: Data on inflammatory 
   biomarkers collected via blood samples and patient self-reported pain intensity 
   and interference from three pilot studies (chronic low back pain, n = 61; 
   arthralgia related to aromatase inhibitors, n = 20; and chemotherapy-induced 
   neuropathy, n = 15) were integrated and analyzed. This paper reports the results 
   based on within-subject treatment effects (change in scores from pre- to post-APA 
   intervention) for each study group (chronic low back pain, cancer pain), 
   between-group differences (changes in scores from pre- to post-intervention 
   between targeted-point APA [T-APA] and non-targeted-point APA [NT-APA]), and 
   correlations among pain intensity, interference, and biomarkers. RESULTS: 
   Within-group analysis (the change score from pre- to post-APA) revealed 
   statistically significant changes in three biomarkers: TNF-α (cancer pain in the 
   APA group, p = .03), β-endorphin (back pain in the APA group, p = .04), and IL-2 
   (back pain in the NT-APA group, p = .002). Based on between-group analysis in 
   patients with chronic low back pain (T-APA vs NT-APA), IL-4 had the largest 
   effect size (0.35), followed by TNF-α (0.29). A strong positive monotonic 
   relationship between IL-1β and IL-2 was detected. CONCLUSIONS: The current 
   findings further support the potential role of inflammatory biomarkers in the 
   analgesic effects of APA. More work is needed to gain a comprehensive 
   understanding of the underlying mechanisms of APA on chronic pain. Because it is 
   simple, inexpensive, and has no negative side effects, APA can be widely 
   disseminated as an alternative to opioids.
C1 University of Texas Health Science Center at Houston Cizik School of Nursing. 
   Johns Hopkins University School of Nursing.
   University of Texas Health Science Center Houston School of Public Health.
   University of Texas Health Science Center Houston School of Public Health.
   University of Texas Health Science Center at Houston Cizik School of Nursing
   University of Texas Health Science Center at Houston, McGovern Medical School.
   Johns Hopkins University Krieger School of Arts and Sciences.
   Johns Hopkins University Krieger School of Arts and Sciences.
   Johns Hopkins University School of Medicine.
EM chao.hsing.yeh@uth.tmc.edu
NR 0
TC 0
SN 1532-863
EI 1524-904
J9 Pain Manag Nurs
PD DEC 22
PY 2022
VL 24
IS 1
BP 19
EP 26
DI 10.1016/j.pmn.2022.11.004 
PG 7
WC Humans; Low Back Pain; therapy; Treatment Outcome; Cancer Pain; Acupressure; methods; Interleukin-2; Tumor Necrosis Factor-alpha
UT PubMed:36543665
PM 36543665
DA 2022-12-22
ER

PT J
AU Oberoi, D
   Reed, EN
   Piedalue, KA
   Landmann, J
   Carlson, LE
AF Oberoi, Devesh
   Reed, Erica N
   Piedalue, Katherine-Ann
   Landmann, Jessa
   Carlson, Linda E
TI Exploring patient experiences and acceptability of group vs. individual 
SO BMC complementary medicine and therapies
LA English
DT Journal Article
DE Acupuncture; Group acupuncture; Individual acupuncture; Oncology; Patient experience; Patient privacy; Qualitative; Social support
AB BACKGROUND: Individual acupuncture (AP) is a safe and effective treatment for 
   cancer-related pain and other symptoms in cancer survivors. However, access to 
   individual AP is limited, and costs can be prohibitive. Group AP could be a more 
   cost-effective alternative as it is less expensive and non-inferior to individual 
   AP for pain relief. Despite growing evidence in favour of group AP, patient 
   acceptability and experience of group AP in cancer patients is relatively 
   unknown. This exploratory study sought to compare patient experiences and 
   acceptability of group versus individual AP in cancer patients. METHODS: 
   Semi-structured, open-ended, in-depth interviews were conducted in a subset of 11 
   cancer patients enrolled in a randomized non-inferiority trial of group vs. 
   individual AP for cancer pain. Participants for this study were recruited via 
   purposive sampling, aiming for diversity in age, sex, education, employment, 
   cancer types, and treatment arms. Data was analyzed using inductive thematic 
   analysis. RESULTS: Two major themes were identified: a) overall experience of AP 
   treatment b) value of AP. Participants across both treatment arms acknowledged 
   improvement in pain, quality of sleep, mood and fatigue. Participants in the 
   group AP arm reported a significant increase in perceived social support, while 
   participants in the individual arm valued privacy and one-on-one interaction with 
   the acupuncturist. Although some participants in the group arm had 
   privacy-related concerns before the commencement of the program, these concerns 
   waned after a few AP sessions. Participants across both the treatment arms 
   reported cordial clinician-patient relationship with the acupuncturist. 
   Willingness to pursue AP treatment in the future was comparable across both the 
   treatment arms and was limited by out-of-pocket costs. CONCLUSION: Patient 
   acceptability and experience of treatment in group AP was on par with individual 
   AP. Group AP may further augment perceived social support among patients and 
   privacy concerns, if any, subside after a few sessions. TRIAL REGISTRATION: 
   ClinicalTrials.gov ( NCT03641222 ). Registered 10 July 2018 - Retrospectively 
   registered.
C1 Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
   Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
   Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
   Vive Integrative Health Group, 1889 - 45 Street NW, Calgary, AB, Canada.
   Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. lcarlso@ucalgary.ca.
   Department of Psychosocial Oncology, Cancer Control Alberta, Tom Baker Cancer 
NR 0
TC 0
SN 2662-767
EI 
J9 BMC Complement Med Ther
PD JUN 14
PY 2022
VL 22
IS 1
BP 155
EP 155
DI 10.1186/s12906-022-03600-6 
PG 0
WC Acupuncture Therapy; Cancer Pain; therapy; Humans; Neoplasms; complications; Pain; Pain Management; Patient Outcome Assessment
UT PubMed:35698124
PM 35698124
DA 2022-06-14
ER

PT J
AU Jia, L
   Wang, K
   Chen, S
AF Jia, Liting
   Wang, Keyi
   Chen, Shuquan
TI Acupuncture combined with opioid for treatment of lung cancer-related pain: A 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Many individuals diagnosed with lung cancer suffer from tremendous 
   pain, and it is crucial to implement more effective measures to assist these 
   patients in alleviating their pain. The present study utilizes a meta-analysis to 
   evaluate the safety and efficacy of acupuncture combined with opioids for 
   treating lung cancer-related pain in patients. METHODS: We have searched 8 
   electronic databases: The Cochrane Library, PubMed, Embase, Web of Science, China 
   National Knowledge Infrastructure, China Science and Technology Journal Database, 
   Wanfang Database, and SinoMed. We included all randomized controlled trials of 
   acupuncture combined with opioids for lung cancer-related pain in adults. We 
   observed the main outcome indicators, including pain relief rates, numeric rating 
   scale scores, and adverse events. Two researchers independently conducted 
   literature screening, literature data extraction, and assessment of bias risk in 
   the literature quality. Any disagreements were resolved through discussions 
   between the 2 researchers or consultations with a third researcher. The risk of 
   bias in the included studies was assessed using the revised risk of bias 
   assessment tool. The overall quality of evidence for each outcome was evaluated 
   using Grading of Recommendations, Assessment, Development and Evaluations. 
   RESULTS: We retrieved 812 lung cancer patients from 11 trials. The study showed 
   that compared to opioids alone, the combination of acupuncture and opioids 
   significantly reduced numeric rating scale scores, increased pain relief rates, 
   and decreased the occurrence of side effects. CONCLUSION: The current evidence 
   indicates that combining acupuncture with opioid analgesics is superior to using 
   opioid analgesics alone for managing lung cancer-related pain. Additionally, this 
   combination therapy has fewer adverse reactions.
C1 Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
   Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
   Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
   Jinan Integrated Traditional Chinese and Western Medicine Hospital, Jinan, 
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD OCT 21
PY 2024
VL 103
IS 42
BP e40158
EP e40158
DI 10.1097/MD.0000000000040158 
PG 1
WC Humans; Acupuncture Therapy; methods; Analgesics, Opioid; therapeutic use; Cancer Pain; therapy; Combined Modality Therapy; Lung Neoplasms; complications; Pain Management; methods; Randomized Controlled Trials as Topic
UT PubMed:39432621
PM 39432621
DA 2024-10-21
ER

PT J
AU Liang, D
   Ren, Y
   Huang, L
   Jin, S
AF Liang, Dongdong
   Ren, Yelong
   Huang, Ledan
   Jin, Shenhui
TI A Study on THE Mechanism of Electroacupuncture to Alleviate Visceral Pain and NGF 
SO Computational intelligence and neuroscience
LA English
DT Journal Article
AB Visceral pain is unbearable, and natural methods are needed to relieve it. 
   Electroacupuncture is a relatively new technique that helps relieve visceral pain 
   by improving blood circulation and providing energy to clogged parts of the body. 
   However, its analgesic effect and mechanism in colorectal pain are still unknown. 
   In this study, the visceral pain models of electroacupuncture in rats were 
   compared and discussed, using nanocomponents to stimulate the expression and 
   mechanism of the nerve growth factor in colorectal pain and electroacupuncture 
   and to observe the expression and mechanism of nerve growth factor in visceral 
   pain relief rats induced by nanocomponents and electroacupuncture. The results 
   show that nanocomponents can effectively relieve visceral pain under the action 
   of electroacupuncture. NGF can activate endogenous proliferation, migration, 
   differentiation, and integration. NSC can promote nerve regeneration and recovery 
   after injury.
C1 Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
   Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
   Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
   Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
NR 0
TC 0
SN 1687-527
EI 1687-526
J9 Comput Intell Neurosci
PD OCT 25
PY 2022
VL 2022
IS 
BP 3755439
EP 3755439
DI 10.1155/2022/3755439 
PG 0
WC Rats; Animals; Electroacupuncture; Visceral Pain; therapy; Nerve Growth Factor; metabolism; Rats, Sprague-Dawley; Analgesics; Colorectal Neoplasms
UT PubMed:36275969
PM 36275969
DA 2022-10-25
ER

PT J
AU Maindet, C
   Burnod, A
   Minello, C
   George, B
   Allano, G
   Lemaire, A
AF Maindet, Caroline
   Burnod, Alexis
   Minello, Christian
   George, Brigitte
   Allano, Gilles
   Lemaire, Antoine
TI Strategies of complementary and integrative therapies in cancer-related 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Review
DE Cancer pain; Complementary therapies; Mind-body therapy; Multimorphic pain; Pain management; Personalized management
AB PURPOSE: Complementary integrative therapies (CITs) correspond to growing demand 
   in patients with cancer-related pain. This demand needs to be considered 
   alongside pharmaceutical and/or interventional therapies. CITs can be used to 
   cover certain specific pain-related characteristics. The objective of this review 
   is to present the options for CITs that could be used within dynamic, 
   multidisciplinary, and personalized management, leading to an integrative 
   oncology approach. METHODS: Critical reflection based on literature analysis and 
   clinical practice. RESULTS: Most CITs only showed trends in efficacy as cancer 
   pain was mainly a secondary endpoint, or populations were restricted. Physical 
   therapy has demonstrated efficacy in motion and pain, in some specific cancers 
   (head and neck or breast cancers) or in treatments sequelae (lymphedema). In 
   cancer survivors, higher levels of physical activity decrease pain intensity. Due 
   to the multimorphism of cancer pain, certain mind-body therapies acting on 
   anxiety, stress, depression, or mood disturbances (such as massage, acupuncture, 
   healing touch, hypnosis, and music therapy) are efficient on cancer pain. Other 
   mind-body therapies have shown trends in reducing the severity of cancer pain and 
   improving other parameters, and they include education (with coping skills 
   training), yoga, tai chi/qigong, guided imagery, virtual reality, and 
   cognitive-behavioral therapy alone or combined. The outcome sustainability of 
   most CITs is still questioned. CONCLUSIONS: High-quality clinical trials should 
   be conducted with CITs, as their efficacy on pain is mainly based on efficacy 
   trends in pain severity, professional judgment, and patient preferences. Finally, 
   the implementation of CITs requires an interdisciplinary team approach to offer 
   optimal, personalized, cancer pain management.
C1 Pain management centre, Grenoble-Alpes University Hospital, Grenoble, France.
   Department of supportive care, Institut Curie, PSL Research University, Paris, France.
   Anaesthesia-intensive care department, Cancer Centre Georges François Leclerc, Dijon, France.
   Pain management unit, Saint-Louis Hospital, Paris, France.
   Pain management unit, Mutualist Clinic of la Porte-de-l'Orient, Lorient, France.
   Oncology and medical specialties department, Valenciennes General Hospital, Valenciennes, France. lemaire-a@ch-valenciennes.fr.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD MAY 12
PY 2019
VL 27
IS 8
BP 3119
EP 3132
DI 10.1007/s00520-019-04829-7 
PG 13
WC Acupuncture Therapy; methods; Cancer Pain; psychology; Complementary Therapies; methods; Humans; Massage; methods; Music Therapy; Neoplasms; therapy; Pain Management; methods; Randomized Controlled Trials as Topic
UT PubMed:31076901
PM 31076901
DA 2019-05-12
ER

PT J
AU Deng, G
   Bao, T
   Mao, JJ
AF Deng, Gary
   Bao, Ting
   Mao, Jun J
TI Understanding the Benefits of Acupuncture Treatment for Cancer Pain Management.
SO Oncology (Williston Park, N.Y.)
LA English
DT Review
AB This article summarizes the current evidence regarding the use of acupuncture for 
   pain management in cancer patients. It includes a description of how acupuncture 
   is thought to work and what the intervention entails, data on acupuncture for 
   managing pain caused by cancer or by cancer treatment (radiation, chemotherapy, 
   endocrine therapy), how acupuncture is practiced in the US medical system, 
   discussion of safety issues, and practical tips on how to integrate acupuncture 
   into cancer care.
NR 0
TC 0
SN 
EI 0890-909
J9 Oncology (Williston Park)
PD JUN 26
PY 2018
VL 32
IS 6
BP 310
EP 6
DI 
PG -304
WC Acupuncture Therapy; methods; Antineoplastic Agents; adverse effects; Aromatase Inhibitors; adverse effects; Arthralgia; etiology; Cancer Pain; therapy; Humans; Musculoskeletal Diseases; etiology; Neoplasms; drug therapy; Pain Management; methods; Peripheral Nervous System Diseases; etiology
UT PubMed:29940063
PM 29940063
DA 2018-06-26
ER

PT J
AU Viscuse, PV
   Price, K
   Millstine, D
   Bhagra, A
   Bauer, B
   Ruddy, KJ
AF Viscuse, Paul V
   Price, Katharine
   Millstine, Denise
   Bhagra, Anjali
   Bauer, Brent
   Ruddy, Kathryn J
TI Integrative medicine in cancer survivors.
SO Current opinion in oncology
LA English
DT Review
AB PURPOSE OF REVIEW: Due to medical advances and an aging population, the number of 
   cancer survivors continues to rise. Survivors often experience late and long-term 
   sequelae of cancer and its treatment (e.g., fatigue, pain, fear of recurrence, 
   and stress). As a result, some patients have utilized or expressed interest in 
   integrative medicine (IM) modalities for prevention of recurrence, optimizing 
   health, enhancing quality of life, and managing symptoms. The purpose of this 
   review is to focus on research published during the past year that informs our 
   understanding of the utility of IM for cancer survivors. RECENT FINDINGS: 
   Physical activity, diet, dietary supplements, mind-body modalities, acupuncture, 
   and massage therapy all may play a role in the management of the physical (e.g., 
   fatigue and pain) and emotional (e.g., anxiety and fear) issues faced by cancer 
   survivors. SUMMARY: IM therapies are appealing to and utilized by many cancer 
   survivors and may reduce symptom burden. Clinicians who provide cancer 
   survivorship care may improve patient care by understanding the evidence for and 
   against their use.
C1 aDepartment of Medicine bDivision of Medical Oncology, Mayo Clinic, Rochester, Minnesota cDivision of Women's Health Internal Medicine, Mayo Clinic, Scottsdale,Arizona, USA.
NR 0
TC 0
SN 1531-703
EI 1040-874
J9 Curr Opin Oncol
PD MAY 2
PY 2017
VL 29
IS 4
BP 235
EP 242
DI 10.1097/CCO.0000000000000376 
PG 7
WC Acupuncture Therapy; Diet; Dietary Supplements; Exercise; Humans; Massage; Mind-Body Therapies; Neoplasms; mortality; Survivors
UT PubMed:28459738
PM 28459738
DA 2017-05-02
ER

PT J
AU Jin, H
   Liang, J
   Zhang, S
   Ma, S
   Qin, H
   Zhang, D
   Pang, X
   Zhang, M
AF Jin, Hong
   Liang, Ji
   Zhang, Siqi
   Ma, Shuai
   Qin, Hongyu
   Zhang, Dongxu
   Pang, Xueying
   Zhang, Miao
TI External treatment of traditional Chinese medicine for cancer pain: A systematic 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Cancer pain is one of the most intolerable and frightening symptoms 
   of cancer patients. However, the clinical effect of the three-step analgesic 
   ladder method (TSAL) is not satisfactory. The combination of external treatment 
   of traditional Chinese medicine (TCM) can improve the clinical effect. OBJECTIVE: 
   This study used network meta-analysis to compare the effects of different 
   external treatment methods of TCM combined with TSAL on cancer pain. METHODS: 
   Databases searched by our team included Google Scholar, Web of Science, Scopus, 
   Embase, PubMed, and Cochrane Library. Randomized controlled trials related to the 
   external treatment of TCM combined with TSAL for cancer pain were screened from 
   the establishment of the database till now. The above literature extracted 
   clinical efficacy, NRS score, KPS score, analgesic onset time, and duration as 
   the main results after the screening. The 95% confidence interval (95% CI) of OR 
   value and SMD value was used as the effect index to compare the difference in 
   efficacy of different interventions, and the ranking was conducted. STATA 17.0 
   software was used for the statistical analysis of the above data. RESULTS: A 
   total of 78 studies were included, including 8 interventions and 5742 
   participants. Based on ranking probability, the clinical effective rate of manual 
   acupuncture combined with TSAL was the best when the intervention time was set at 
   4 weeks [OR = 5.42, 95% CI (1.99,14.81)], and the improvement effect on KPS score 
   was also the best [SMD = 0.97, 95% CI (0.61, 1.33)]. Acupoint external 
   application was the best intervention in reducing NRS score [SMD = -1.14, 95% CI 
   (-1.90, -0.93)]. Acupoint moxibustion combined with TSAL was considered to be the 
   most effective intervention to prolong the duration of analgesia [SMD = 1.69, 95% 
   CI (0.84, 2.54)] and shortening the onset time of analgesia [SMD = -3.00, 95% CI 
   (-4.54, -1.47)]. CONCLUSIONS: TSAL combined with manual acupuncture is the best 
   in terms of clinical efficacy and improvement of patients' functional activity 
   status. With the extension of treatment time, the intervention of this kind of 
   treatment on the clinical effect is more pronounced. Acupoint external 
   application also has a unique advantage in reducing the pain level of patients. 
   From the point of view of analgesic duration and duration of analgesia, combined 
   acupoint moxibustion has the best effect.
C1 Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Oncology Department, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
   Acupuncture and Moxibustion Consulting Room No. 10, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD FEB 23
PY 2024
VL 103
IS 8
BP e37024
EP e37024
DI 10.1097/MD.0000000000037024 
PG 1
WC Humans; Medicine, Chinese Traditional; methods; Cancer Pain; therapy; Acupuncture Therapy; methods; Pain Management; methods; Randomized Controlled Trials as Topic; Treatment Outcome; Combined Modality Therapy; Pain Measurement; Analgesics; therapeutic use
UT PubMed:38394488
PM 38394488
DA 2024-02-23
ER

PT J
AU Wu, JL
   Qin, JF
   Qin, JX
   Cheng, CH
   Sun, ZR
   Qin, XY
AF Wu, Jian-Li
   Qin, Jian-Feng
   Qin, Jian-Xiong
   Cheng, Cai-Hong
   Sun, Zhong-Ren
   Qin, Xun-Yun
TI [Research progress on analgesic mechanism of acupuncture for cancer pain].
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Review
DE Acupuncture; Cancer pain; Mechanism; Research progress
AB Cancer pain is one of the common complications in patients with intermediate or 
   advanced cancer, which brings severe sufferings to patients and their families, 
   and also seriously interferes with the anti-tumor process. Acupuncture is an 
   effective method for the treatment of cancer pain, which has the advantages of 
   simple operation, quick effect and fewer side effects, and is widely used in 
   clinic. In this paper, we reviewed the relevant literature on the mechanisms of 
   acupuncture in the treatment of cancer pain both at home and abroad in recent 
   years, and summarized the analgesic mechanisms of acupuncture for cancer pain 
   from the peripheral level and the central level. It is found that acupuncture can 
   relieve cancer pain by regulating immune inflammatory response, expression of ion 
   channels and pain-related receptors, remising central sensitization, activating 
   endogenous pain modulating system and suppressing pain transmission pathways. In 
   addition, we also think that the use of high-throughput multi-omics techniques 
   and neuroimaging methods to detect and analyze the brain areas or body fluids 
   before and after acupuncture should be the focus of acupuncture analgesia 
   research in the future.
C1 Heilongjiang University of Chinese Medicine, Harbin 150040, China.
   Research Institute of Heilongjiang Dekun Yao-Minority Medicine, Daqing 163311, 
   Beijing Yao-Minority Medicine Hospital, Beijing 100070.
   Beijing Yao-Minority Medicine Hospital, Beijing 100070.
   Beijing Yao-Minority Medicine Hospital, Beijing 100070.
   Heilongjiang University of Chinese Medicine, Harbin 150040, China.
   Research Institute of Heilongjiang Dekun Yao-Minority Medicine, Daqing 163311, Heilongjiang Province. 13910576999@163.com.
   Beijing Yao-Minority Medicine Hospital, Beijing 100070. 13910576999@163.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD NOV 19
PY 2024
VL 49
IS 11
BP 1220
EP 1225
DI 10.13702/j.1000-0607.20230591 
PG 5
WC Humans; Acupuncture Analgesia; Cancer Pain; therapy; Animals; Neoplasms; therapy; Acupuncture Therapy; Pain Management
UT PubMed:39557440
PM 39557440
DA 2024-11-19
ER

PT J
AU Wan, Q
   Chen, H
   Wang, X
   Xi, H
   Zheng, S
   Luo, S
   Wu, W
   Pan, R
AF Wan, Qingyun
   Chen, Hao
   Wang, Xiaoqiu
   Xi, Hanqing
   Zheng, Shiyu
   Luo, Shuting
   Wu, Wenzhong
   Pan, Rui
TI Effectiveness of different acupuncture therapies for chronic cancer pain: A 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Pain is a common and distressing symptom experienced by cancer 
   patients. Previous research found acupuncture was associated with significant 
   reductions in pain intensity and opioid use. Acupuncture therapies are various, 
   and the difference in efficacy and safety has never been assessed. This paper 
   aims to assess and rank the effectiveness of the different acupuncture methods 
   and provide an acupuncture treatment guideline for relieving chronic pain in 
   cancer survivors. METHODS: Four English databases (PubMed, Embase, Cochrane 
   library, and Web of Science) and 4 Chinese databases (China National Knowledge 
   Infrastructure, Wanfang Data, and Chinese Biomedical Literature Database) will be 
   searched for randomized controlled trials (RCTs) published from the database 
   inception to November 30, 2021. The primary outcomes will be patient-reported 
   pain intensity measured by the Brief Pain Inventory, Visual Analog Scale, Verbal 
   Rating Scale, Numerical Rating Scale, and other valid outcome measures. The 
   Grading of Recommendations Assessment, and Development and Evaluation System will 
   evaluate the quality of evidence. Bayesian network meta-analysis will be 
   performed in WinBUGS V.1.4.3 to determine the comparative effectiveness of the 
   acupuncture therapies. RESULTS: This study will quantify the effectiveness of 
   each acupuncture intervention for chronic cancer pain with pain scores and the 
   use of analgesics. The adverse events of acupuncture treatment for cancer pain 
   will also be reported. CONCLUSION: The conclusion of our study will help 
   physicians and patients choose suitable acupuncture methods to manage cancer 
   pain.
C1 Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Nanjing University of Chinese Medicine, Nanjing, China.
   Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Jiangsu Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JAN 29
PY 2022
VL 101
IS 4
BP e27965
EP e27965
DI 10.1097/MD.0000000000027965 
PG 1
WC Acupuncture Therapy; Cancer Pain; therapy; Chronic Pain; etiology; Humans; Neoplasms; complications; Pain Measurement; Research Design; Network Meta-Analysis as Topic
UT PubMed:35089187
PM 35089187
DA 2022-01-29
ER

PT J
AU Zhang, K
   Gao, C
   Li, C
   Li, Y
   Wang, S
   Tang, Q
   Zhao, C
   Zhai, J
AF Zhang, Kai
   Gao, Chao
   Li, Chengyu
   Li, Yan
   Wang, Shenjun
   Tang, Qilin
   Zhao, Chen
   Zhai, Jingbo
TI Acupuncture for Acute Pancreatitis: A Systematic Review and Meta-analysis.
SO Pancreas
LA English
DT Journal Article
AB OBJECTIVE: The objective of this study was to assess the efficacy and safety of 
   acupuncture plus routine treatment (RT) for acute pancreatitis (AP). METHODS: 
   Literature searches were performed in 8 databases up to October 31, 2018. 
   Randomized controlled trials comparing acupuncture plus RT with RT alone for AP 
   were included. RESULTS: Twelve eligible studies were included finally. The 
   meta-analysis showed that acupuncture plus RT compared with RT alone could 
   significantly improve the total effective rate and gastrointestinal function and 
   reduce the Acute Physiology, Age, Chronic Health Evaluation II score, tumor 
   necrosis factor α count, the time of resuming to diets, and the length of 
   hospital stay. Only 3 of the studies reported adverse events or reactions. 
   CONCLUSIONS: This study suggested that acupuncture combined with RT may be 
   effective for AP. However, more rigorously designed randomized controlled trials 
   are warranted to confirm the current findings.
C1 From the Department of Acupuncture and Moxibustion, Tianjin Gong An Hospital.
   Tianjin Medical University General Hospital, Tianjin Institute of General Surgery, Tianjin.
   Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing.
   From the Department of Acupuncture and Moxibustion, Tianjin Gong An Hospital.
   Research Center of Experimental Acupuncture Science, School of Acumox and Tuina, Tianjin University of Traditional Chinese Medicine.
   Graduate College, Tianjin University of Traditional Chinese Medicine, Tianjin.
   Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing.
   Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
NR 0
TC 0
SN 1536-482
EI 
J9 Pancreas
PD OCT 9
PY 2019
VL 48
IS 9
BP 1136
EP 1147
DI 10.1097/MPA.0000000000001399 
PG 11
WC Abdominal Pain; therapy; Acupuncture Therapy; methods; Acute Disease; Female; Humans; Male; Outcome Assessment, Health Care; methods; Pancreatitis; drug therapy; Randomized Controlled Trials as Topic; statistics & numerical data; Tumor Necrosis Factor-alpha; metabolism
UT PubMed:31593017
PM 31593017
DA 2019-10-09
ER

PT J
AU Lyu, Z
   Guo, Y
   Gong, Y
   Fan, W
   Dou, B
   Li, N
   Wang, S
   Xu, Y
   Liu, Y
   Chen, B
   Guo, Y
   Xu, Z
   Lin, X
AF Lyu, Zhongxi
   Guo, Yongming
   Gong, Yinan
   Fan, Wen
   Dou, Baomin
   Li, Ningcen
   Wang, Shenjun
   Xu, Yuan
   Liu, Yangyang
   Chen, Bo
   Guo, Yi
   Xu, Zhifang
   Lin, Xiaowei
TI The Role of Neuroglial Crosstalk and Synaptic Plasticity-Mediated Central 
SO Neural plasticity
LA English
DT Review
AB Although pain is regarded as a global public health priority, analgesic therapy 
   remains a significant challenge. Pain is a hypersensitivity state caused by 
   peripheral and central sensitization, with the latter considered the culprit for 
   chronic pain. This study summarizes the pathogenesis of central sensitization 
   from the perspective of neuroglial crosstalk and synaptic plasticity and 
   underlines the related analgesic mechanisms of acupuncture. Central sensitization 
   is modulated by the neurotransmitters and neuropeptides involved in the ascending 
   excitatory pathway and the descending pain modulatory system. Acupuncture 
   analgesia is associated with downregulating glutamate in the ascending excitatory 
   pathway and upregulating opioids, 𝛾-aminobutyric acid, norepinephrine, and 
   5-hydroxytryptamine in the descending pain modulatory system. Furthermore, it is 
   increasingly appreciated that neurotransmitters, cytokines, and chemokines are 
   implicated in neuroglial crosstalk and associated plasticity, thus contributing 
   to central sensitization. Acupuncture produces its analgesic action by inhibiting 
   cytokines, such as interleukin-1β, interleukin-6, and tumor necrosis factor-α, 
   and upregulating interleukin-10, as well as modulating chemokines and their 
   receptors such as CX3CL1/CX3CR1, CXCL12/CXCR4, CCL2/CCR2, and CXCL1/CXCR2. These 
   factors are regulated by acupuncture through the activation of multiple signaling 
   pathways, including mitogen-activated protein kinase signaling (e.g., the p38, 
   extracellular signal-regulated kinases, and c-Jun-N-terminal kinase pathways), 
   which contribute to the activation of nociceptive neurons. However, the responses 
   of chemokines to acupuncture vary among the types of pain models, acupuncture 
   methods, and stimulation parameters. Thus, the exact mechanisms require future 
   clarification. Taken together, inhibition of central sensitization modulated by 
   neuroglial plasticity is central in acupuncture analgesia, providing a novel 
   insight for the clinical application of acupuncture analgesia.
C1 Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional 
   National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional 
   National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Suzuka University of Medical Science, Suzuka 5100293, Japan.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional 
   National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional 
   National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional 
   National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional 
   National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional 
   National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
NR 0
TC 0
SN 1687-544
EI 2090-590
J9 Neural Plast
PD FEB 4
PY 2021
VL 2021
IS 
BP 8881557
EP 8881557
DI 10.1155/2021/8881557 
PG 0
WC Acupuncture Analgesia; methods; Animals; Cytokines; immunology; Humans; Neuroglia; immunology; Neuronal Plasticity; physiology; Pain; immunology; Pain Management; methods
UT PubMed:33531894
PM 33531894
DA 2021-02-04
ER

PT J
AU Ben-Arye, E
   Segev, Y
   Galil, G
   Marom, I
   Gressel, O
   Stein, N
   Hirsh, I
   Samuels, N
   Schmidt, M
   Schiff, E
   Lurie, I
   Lavie, O
AF Ben-Arye, Eran
   Segev, Yakir
   Galil, Galit
   Marom, Inbal
   Gressel, Orit
   Stein, Nili
   Hirsh, Irena
   Samuels, Noah
   Schmidt, Meirav
   Schiff, Elad
   Lurie, Irina
   Lavie, Ofer
TI Acupuncture during gynecological oncology surgery: A randomized controlled trial 
SO Cancer
LA English
DT Journal Article
DE acupuncture; anxiety; gynecological oncology; integrative medicine; integrative oncology; pain; peri-operative
AB BACKGROUND: In this study, the impact of a multimodal integrative oncology pre- 
   and intraoperative intervention on pain and anxiety among patients undergoing 
   gynecological oncology surgery was explored. METHODS: Study participants were 
   randomized to three groups: Group A received preoperative touch/relaxation 
   techniques, followed by intraoperative acupuncture; Group B received preoperative 
   touch/relaxation only; and a control group (Group C) received standard care. Pain 
   and anxiety were scored before and after surgery using the Measure Yourself 
   Concerns and Wellbeing (MYCAW) and Quality of Recovery (QOR-15) questionnaires, 
   using Part B of the QOR to assess pain, anxiety, and other quality-of-life 
   parameters. RESULTS: A total of 99 patients participated in the study: 45 in 
   Group A, 25 in Group B, and 29 in Group C. The three groups had similar baseline 
   demographic and surgery-related characteristics. Postoperative QOR-Part B scores 
   were significantly higher in the treatment groups (A and B) when compared with 
   controls (p = .005), including for severe pain (p = .011) and anxiety (p = .007). 
   Between-group improvement for severe pain was observed in Group A compared with 
   controls (p = .011). Within-group improvement for QOR depression subscales was 
   observed in only the intervention groups (p <0.0001). Compared with Group B, 
   Group A had better improvement of MYCAW-reported concerns (p = .025). 
   CONCLUSIONS: A preoperative touch/relaxation intervention may significantly 
   reduce postoperative anxiety, possibly depression, in patients undergoing 
   gynecological oncology surgery. The addition of intraoperative acupuncture 
   significantly reduced severe pain when compared with controls. Further research 
   is needed to confirm these findings and better understand the impact of 
   intraoperative acupuncture on postoperative pain. PLAIN LANGUAGE SUMMARY: 
   Integrative oncology programs are increasingly becoming part of 
   supportive/palliative care, with many working within the Society for Integrative 
   Oncology. This study examined the impact of a multimodal integrative oncology 
   program on pain and anxiety among 99 patients undergoing gynecological oncology 
   surgery. Participants were randomized to three groups: preoperative 
   touch/relaxation treatments, followed by intraoperative acupuncture; preoperative 
   touch/relaxation without acupuncture; and a control group receiving standard care 
   only. The preoperative touch/relaxation intervention significantly reduced 
   perioperative anxiety, with the addition of intraoperative acupuncture 
   significantly reducing severe pain as well, when compared with controls. Further 
   research is needed to confirm these findings.
C1 Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, Haifa, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
   Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, Haifa, Israel.
   Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
   Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, Haifa, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 
   Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel.
   Department of Anesthesiology, Critical Care and Pain Medicine, Carmel Medical Center, Haifa, Israel.
   Center for Integrative Complementary Medicine, Shaarei Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
   Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Department of Internal Medicine & Integrative Medicine Service, Bnai-Zion, 
   Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
NR 0
TC 0
SN 1097-014
EI 
J9 Cancer
PD JAN 18
PY 2023
VL 129
IS 6
BP 908
EP 919
DI 10.1002/cncr.34542 
PG 11
WC Female; Humans; Acupuncture Therapy; Genital Neoplasms, Female; surgery; Anxiety; etiology; Pain, Postoperative; etiology; Medical Oncology
UT PubMed:36647622
PM 36647622
DA 2023-01-18
ER

PT J
AU Xie, T
   Liu, C
   Wu, Y
   Li, X
   Yang, Q
   Tan, J
AF Xie, Tianle
   Liu, Can
   Wu, Yudi
   Li, Xiuxiu
   Yang, Qianyun
   Tan, Jing
TI Efficacy and Safety of Different Acupuncture Treatments for Cancer-Related Pain: 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; cancer; cancer pain; meta-analysis
AB BACKGROUND: Cancer pain is a prevalent and persistent issue, and while there have 
   been some observations of the possible benefits of acupuncture in managing cancer 
   pain, there is still debate regarding its safety and effectiveness. This study 
   aims to compare the efficacy and safety of different acupuncture modalities in 
   the treatment of cancer pain through a network meta-analysis. METHODS: Between 
   the time each database was created and June 3, 2024, eight databases were 
   queried: PubMed, Cochrane, Embase, Web of Science, CNKI, Wanfang, VIP, and China 
   Biomedicine. Randomized controlled trials investigating the use of various 
   acupuncture and moxibustion techniques in the treatment of cancer pain were 
   identified. Publication bias and quality of randomized controlled trials were 
   assessed using the Cochrane Risk of Bias tool and the Jadad scale, and network 
   meta-analyses were performed using Stata 15 and R 4.3.2. RESULTS: We incorporated 
   111 studies encompassing 9549 individuals diagnosed with cancer, examining 29 
   distinct therapies. Network meta-analysis showed that, compared to Usual 
   Medicine, Acupuncture + Usual Medicine + Traditional Chinese medicine 
   (MD = -1.83, 95% CI: -2.86 to -0.80) could reduce NRS scores, 
   Acupuncture + Traditional Chinese medicine (OR = 30.86, 95% CI: 3.75-254.20) 
   could improve cancer pain relief, Moxibustion + Usual Medicine (MD = 2.12, 95% 
   CI: 0.43-3.80) could effectively improve KPS score, Acupuncture + Application of 
   Chinese medicine (OR = 0.16, 95% CI: 0.04-0.66) is associated with a lower 
   incidence of constipation, Electro-Acupuncture + Usual Medicine (OR = 0.11, 95% 
   CI: 0.03-0.45) shows a lower incidence of nausea and vomiting, 
   Acupuncture + Moxibustion + Usual Medicine (OR = 0.29, 95% CI: 0.09-0.90) is 
   associated with a lower incidence of dizziness. CONCLUSION: 
   Acupuncture + Traditional Chinese medicine is the best intervention for different 
   acupuncture methods in the treatment of cancer pain, and Moxibustion + Usual 
   Medicine is the best intervention to improve the quality of life of patients.
C1 Hunan University of Chinese Medicine, Changsha, Hunan, China.
   Hunan University of Chinese Medicine, Changsha, Hunan, China.
   Hunan University of Chinese Medicine, Changsha, Hunan, China.
   Hunan University of Chinese Medicine, Changsha, Hunan, China.
   Hunan University of Chinese Medicine, Changsha, Hunan, China.
   Hunan University of Chinese Medicine, Changsha, Hunan, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD JAN 28
PY 2025
VL 24
IS 
BP 15347354251314500
EP 15347354251314500
DI 10.1177/15347354251314500 
PG 1
WC Humans; Acupuncture Therapy; methods; Cancer Pain; therapy; Medicine, Chinese Traditional; methods; Moxibustion; methods; Neoplasms; complications; Pain Management; methods; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:39873173
PM 39873173
DA 2025-01-28
ER

PT J
AU Kutcher, AM
   LeBaron, VT
AF Kutcher, Anna M
   LeBaron, Virginia T
TI Evaluating Acupuncture for the Treatment of Chemotherapy-induced Peripheral 
SO Western journal of nursing research
LA English
DT Review
DE acupuncture; cancer; chemotherapy-induced peripheral neuropathy; electro-acupuncture; integrative oncology; integrative review
AB The purpose of this integrative review of the literature is to synthesize the 
   current evidence and identify gaps in knowledge regarding the effectiveness of 
   acupuncture to treat chemotherapy-induced peripheral neuropathy (CIPN). PubMed, 
   CINAHL, Web of Science, and Cochrane Review databases were searched using 
   inclusion criteria: keywords acupuncture, cancer, and peripheral neuropathy, 
   published in English, between 2009 and 2019. Sixteen articles met the inclusion 
   criteria. The literature indicates that acupuncture is generally well tolerated 
   by patients with cancer, and a majority of patients with CIPN reported decreased 
   pain and increased quality of life after receiving acupuncture treatment. A 
   comprehensive understanding of the ability of acupuncture to treat CIPN is 
   limited by variability of acupuncture techniques and inconsistency in measures of 
   evaluation.
C1 University of Virginia School of Nursing, Charlottesville, VA, USA.
   University of Virginia School of Nursing, Charlottesville, VA, USA.
NR 0
TC 0
SN 1552-845
EI 
J9 West J Nurs Res
PD FEB 10
PY 2021
VL 44
IS 2
BP 169
EP 179
DI 10.1177/0193945921992538 
PG 10
WC Acupuncture Therapy; methods; Antineoplastic Agents; adverse effects; Humans; Neoplasms; drug therapy; Peripheral Nervous System Diseases; chemically induced; Quality of Life
UT PubMed:33559535
PM 33559535
DA 2021-02-10
ER

PT J
AU Badel, T
   Zadravec, D
   Bašić, Kes V
   Smoljan, M
   Kocijan, Lovko S
   Zavoreo, I
   Krapac, L
   Anić, Milošević S
AF Badel, Tomislav
   Zadravec, Dijana
   Bašić Kes, Vanja
   Smoljan, Mia
   Kocijan Lovko, Sandra
   Zavoreo, Iris
   Krapac, Ladislav
   Anić Milošević, Sandra
TI OROFACIAL PAIN - DIAGNOSTIC AND THERAPEUTIC CHALLENGES.
SO Acta clinica Croatica
LA English
DT Journal Article
DE anxiety; orofacial pain; temporomandibular joint; trigeminal neuralgia
AB The concept of diagnostics and therapy of musculoskeletal and neuropathic 
   diseases of the stomatognathic system, which are the subject of this paper, has 
   been developing for decades. It can be said that in order to avoid 
   misunderstanding, the orofacial pain as a clinical problem, in the narrower 
   sense, involves non-odontogenic and non-malignant causes of orofacial region. In 
   this study, the results of clinical diagnosis of the population of 557 
   consecutive patients with orofacial pain based on multidisciplinary diagnostics 
   were evaluated. 15.6% of patients have given up on the participation in the 
   study. It has been shown that the patients who dropped out of the study were 
   significantly older (p=0.0411) than those who agreed to participate, but there 
   was no difference in gender ratio (p=0.185) since the proportion of female 
   patients prevailed. In an analysis of 84.4% of patients participating in the 
   study, the elevated anxiety values were established (mean value on STAI 1 was 
   39.2 and STAI 2 was 41.1) and statistical significance was found in correlation 
   between elevated anxiety and intensity of pain as shown on visual analogue scale 
   on open mouth (p<0.0001). Compared to the age, the statistical significance was 
   for STAI 1 (p=0.0097) but not for STAI 2 (p=0.5599). The most common form of 
   therapy is Michigan stabilization splint: for disc displacement of 
   temporomandibular joint (TMJ) in 38.9% of patients and in combination with 
   physiotherapy in 18.7% of patients; for osteoarthritis of TMJ in 28.4% and in 
   combination with physiotherapy in 26.4% of patients. The treatment with 
   anticonvulsant drugs for trigeminal neuralgia predominates in 54.3% of patients, 
   which is combined with acupuncture in 25.7% of patients and only acupuncture in 
   17.1% of patients. In this study, a multidisciplinary co-operation in initial 
   diagnostics and differential was designed to develop subspecialist knowledge on 
   orofacial pain.
C1 1Department of Removable Prosthodontics, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
   2Department of Diagnostic and Interventional Radiology,Sestre milosrdnice University Hospital Center, University of Zagreb, Zagreb,Croatia
   3Department of Neurology, Sestre milosrdnice University Hospital Center,University of Zagreb, Zagreb, Croatia
   4Psychiatry Hospital "Sv Ivan", Zagreb,Croatia
   5Academy of Medical Sciences of Croatia, Department of Public Health,Zagreb, Croatia
   6Department of Orthodontics, School of Dental Medicine,University of Zagreb, Zagreb, Croatia.
   1Department of Removable Prosthodontics, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
   2Department of Diagnostic and Interventional Radiology,Sestre milosrdnice University Hospital Center, University of Zagreb, Zagreb,Croatia
   3Department of Neurology, Sestre milosrdnice University Hospital Center,University of Zagreb, Zagreb, Croatia
   4Psychiatry Hospital "Sv Ivan", Zagreb,Croatia
   5Academy of Medical Sciences of Croatia, Department of Public Health,Zagreb, Croatia
   6Department of Orthodontics, School of Dental Medicine,University of Zagreb, Zagreb, Croatia.
   1Department of Removable Prosthodontics, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
   2Department of Diagnostic and Interventional Radiology,Sestre milosrdnice University Hospital Center, University of Zagreb, Zagreb,Croatia
   3Department of Neurology, Sestre milosrdnice University Hospital Center,University of Zagreb, Zagreb, Croatia
   4Psychiatry Hospital "Sv Ivan", Zagreb,Croatia
   5Academy of Medical Sciences of Croatia, Department of Public Health,Zagreb, Croatia
   6Department of Orthodontics, School of Dental Medicine,University of Zagreb, Zagreb, Croatia.
   1Department of Removable Prosthodontics, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
   2Department of Diagnostic and Interventional Radiology,Sestre milosrdnice University Hospital Center, University of Zagreb, Zagreb,Croatia
   3Department of Neurology, Sestre milosrdnice University Hospital Center,University of Zagreb, Zagreb, Croatia
   4Psychiatry Hospital "Sv Ivan", Zagreb,Croatia
   5Academy of Medical Sciences of Croatia, Department of Public Health,Zagreb, Croatia
   6Department of Orthodontics, School of Dental Medicine,University of Zagreb, Zagreb, Croatia.
   1Department of Removable Prosthodontics, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
   2Department of Diagnostic and Interventional Radiology,Sestre milosrdnice University Hospital Center, University of Zagreb, Zagreb,Croatia
   3Department of Neurology, Sestre milosrdnice University Hospital Center,University of Zagreb, Zagreb, Croatia
   4Psychiatry Hospital "Sv Ivan", Zagreb,Croatia
   5Academy of Medical Sciences of Croatia, Department of Public Health,Zagreb, Croatia
   6Department of Orthodontics, School of Dental Medicine,University of Zagreb, Zagreb, Croatia.
   1Department of Removable Prosthodontics, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
   2Department of Diagnostic and Interventional Radiology,Sestre milosrdnice University Hospital Center, University of Zagreb, Zagreb,Croatia
   3Department of Neurology, Sestre milosrdnice University Hospital Center,University of Zagreb, Zagreb, Croatia
   4Psychiatry Hospital "Sv Ivan", Zagreb,Croatia
   5Academy of Medical Sciences of Croatia, Department of Public Health,Zagreb, Croatia
   6Department of Orthodontics, School of Dental Medicine,University of Zagreb, Zagreb, Croatia.
   1Department of Removable Prosthodontics, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
   2Department of Diagnostic and Interventional Radiology,Sestre milosrdnice University Hospital Center, University of Zagreb, Zagreb,Croatia
   3Department of Neurology, Sestre milosrdnice University Hospital Center,University of Zagreb, Zagreb, Croatia
   4Psychiatry Hospital "Sv Ivan", Zagreb,Croatia
   5Academy of Medical Sciences of Croatia, Department of Public Health,Zagreb, Croatia
   6Department of Orthodontics, School of Dental Medicine,University of Zagreb, Zagreb, Croatia.
   1Department of Removable Prosthodontics, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
   2Department of Diagnostic and Interventional Radiology,Sestre milosrdnice University Hospital Center, University of Zagreb, Zagreb,Croatia
   3Department of Neurology, Sestre milosrdnice University Hospital Center,University of Zagreb, Zagreb, Croatia
   4Psychiatry Hospital "Sv Ivan", Zagreb,Croatia
   5Academy of Medical Sciences of Croatia, Department of Public Health,Zagreb, Croatia
   6Department of Orthodontics, School of Dental Medicine,University of Zagreb, Zagreb, Croatia.
NR 0
TC 0
SN 1333-945
EI 0353-946
J9 Acta Clin Croat
PD NOV 20
PY 2019
VL 58
IS Suppl 1
BP 82
EP 89
DI 10.20471/acc.2019.58.s1.12 
PG 7
WC Acupuncture Therapy; Adolescent; Adult; Aged; Aged, 80 and over; Anxiety; etiology; Child; Facial Pain; etiology; Female; Humans; Male; Middle Aged; Osteoarthritis; complications; Pain Measurement; Physical Therapy Modalities; Temporomandibular Joint; Temporomandibular Joint Disorders; complications; Trigeminal Neuralgia; complications; Young Adult
UT PubMed:31741564
PM 31741564
DA 2019-11-20
ER

PT J
AU Maurer, J
   Friedemann, T
   Chen, Y
   Ambrosini, F
   Knipper, S
   Maurer, T
   Heinzer, H
   Thederan, I
   Schroeder, S
AF Maurer, Jean
   Friedemann, Thomas
   Chen, Yuelai
   Ambrosini, Francesca
   Knipper, Sophie
   Maurer, Tobias
   Heinzer, Hans
   Thederan, Imke
   Schroeder, Sven
TI A randomized controlled study on acupuncture for peri-operative pain after open 
SO BJU international
LA English
DT Journal Article
DE acupuncture; open radical prostatectomy; pain reduction; peri‐operative pain; press tack needle; prostate cancer
AB OBJECTIVES: To evaluate the advantages of adding acupuncture to standard 
   postoperative pain management for open radical prostatectomy (RP). MATERIALS AND 
   METHODS: A randomized controlled trial (1:1:1) comparing routine postoperative 
   analgesic care (control [CON]) vs the addition of press tack needle acupuncture 
   (ACU) or press tack placebo acupressure (SHAM) for pain management after open RP 
   was performed. A total of 126 patients were enrolled between February 2020 and 
   April 2021. After open RP, the CON group received standard postoperative 
   analgesia, the ACU group received long-term acupuncture with press tacks at 
   specific points (P-6, Shenmen and SP-6) along with standard analgesia, and the 
   SHAM group received placebo press tacks at the same acupuncture points alongside 
   standard analgesia. The primary endpoint was postoperative pain measured on a 
   numeric rating scale, the NRS-11, calculated as the area under the curve. The 
   cumulative use of routine postoperative analgesics, time to first defaecation, 
   and quality of life were analysed using the Kruskal-Wallis rank sum test, 
   Fisher's exact test, and Pearson's chi-squared test. RESULTS: The ACU group 
   reported significantly less postoperative pain compared to the SHAM (P = 0.007) 
   and CON groups (P = 0.02). There were no significant difference in median 
   (interquartile range) cumulative pain medication usage, time to first defaecation 
   (CON: 37 [33, 44] h; SHAM: 37 [33, 42] h; ACU: 37 [33, 41] h; P > 0.9), or health 
   status at discharge (EuroQol five-dimension, five-level general health assessment 
   questionnaire: CON: 70 [65-83]; SHAM: 70 [60-80]; ACU: 70 [50-80]). CONCLUSION: 
   Incorporating acupuncture into postoperative pain management can improve patient 
   postoperative outcomes.
C1 Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
   HanseMerkur Center for Traditional Chinese Medicine at the University Hospital Hamburg-Eppendorf, Hamburg, Germany.
   Longhua Hospital Affiliated to Shanghai University of TCM, Shanghai, China.
   Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
   IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
   Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
   Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
   Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
   Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
   Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
   HanseMerkur Center for Traditional Chinese Medicine at the University Hospital Hamburg-Eppendorf, Hamburg, Germany.
NR 0
TC 0
SN 1464-410
EI 
J9 BJU Int
PD FEB 6
PY 2024
VL 133
IS 6
BP 725
EP 732
DI 10.1111/bju.16288 
PG 7
WC Humans; Prostatectomy; adverse effects; Male; Pain, Postoperative; etiology; Middle Aged; Aged; Acupuncture Therapy; methods; Pain Measurement; Pain Management; methods; Prostatic Neoplasms; surgery; Acupuncture Analgesia; methods; Quality of Life
UT PubMed:38316611
PM 38316611
DA 2024-02-06
ER

PT J
AU Paley, CA
   Johnson, MI
   Bennett, MI
AF Paley, Carole A
   Johnson, Mark I
   Bennett, Michael I
TI Acupuncture: a treatment for breakthrough pain in cancer?
SO BMJ supportive & palliative care
LA English
DT Review
AB CONTEXT: Patients with chronic cancer pain frequently suffer severe exacerbations 
   of pain intensity which are difficult to control adequately via pharmaceutical 
   management. Management of these episodes of breakthrough pain (BTP) presents a 
   challenge both to the physician and the patient, and supplemental 'rescue' doses 
   of opioids required to control BTP can produce intolerable side-effects and often 
   do not act rapidly enough to provide adequate analgesia. There is very little 
   evidence to support the use of acupuncture for BTP in cancer and few studies have 
   considered the rapidity of the analgesic response to acupuncture for any type of 
   pain. However, the available physiological evidence provides a convincing 
   rationale and one which warrants research. OBJECTIVE: The objective of this paper 
   is to debate the available physiological evidence for a rapid analgesic response 
   to acupuncture in the context of the needs of the patient with cancer BTP, 
   current interventions, acupuncture technique and the practical considerations 
   involved in administering treatment rapidly and safely. CONCLUSION: Current 
   evidence suggests that acupuncture has the potential to produce rapid and 
   effective analgesia when needles are inserted deeply enough and manipulated 
   sufficiently. For cancer BTP this represents a possible adjunctive treatment, and 
   consideration should be given to administering acupuncture alongside 'rescue' 
   doses of medication to 'kick-start' the analgesic response before the medication 
   takes effect. However, research is needed to provide evidence that acupuncture is 
   effective for BTP in cancer, and the feasibility, practicality and safety of 
   patients administering acupuncture themselves must also be taken into account.
C1 Research & Effectiveness Department, Airedale NHS Foundation Trust, Steeton, Keighley, UK.
NR 0
TC 0
SN 2045-436
EI 
J9 BMJ Support Palliat Care
PD DEC 1
PY 2011
VL 1
IS 3
BP 335
EP 8
DI 10.1136/bmjspcare-2011-000066 
PG -327
WC Acupuncture Therapy; methods; Breakthrough Pain; etiology; Humans; Neoplasms; complications; Pain Measurement; Time Factors; Treatment Outcome
UT PubMed:24653480
PM 24653480
DA 2011-12-01
ER

PT J
AU Cassileth, BR
   Keefe, FJ
AF Cassileth, Barrie R
   Keefe, Francis J
TI Integrative and behavioral approaches to the treatment of cancer-related 
SO The oncologist
LA English
DT Review
AB Integrative oncology is the synthesis of mainstream cancer care and 
   evidence-based complementary therapies. Complementary strategies include massage 
   therapies, acupuncture, fitness, and mind-body techniques, which take advantage 
   of the reciprocal relationship between the mind and body. Neuropathic pain--and 
   pain more generally--is part of a complex process involving the whole physical 
   and psychosocial being, therefore requiring an integrative management approach. 
   Several studies have demonstrated, for example, that social context plays an 
   important role in the perception of pain and that a patient's coping strategies 
   can influence the persistence of pain. In this article, we briefly describe 
   research illustrating the promise of integrative approaches for the treatment of 
   cancer-related neuropathic pain.
C1 Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
NR 0
TC 0
SN 1549-490
EI 
J9 Oncologist
PD MAY 28
PY 2010
VL 15 Suppl 2
IS 
BP 19
EP 23
DI 10.1634/theoncologist.2009-S504 
PG 4
WC Acupuncture Therapy; Cognitive Behavioral Therapy; Humans; Hypnosis; Massage; Neoplasms; complications; Neuralgia; etiology
UT PubMed:20489193
PM 20489193
DA 2010-05-28
ER

PT J
AU Tang, J
   Sun, Z
   Wang, Y
   Liu, J
   Wang, S
   Wang, X
AF Tang, Jie
   Sun, Zhilu
   Wang, Yan
   Liu, Jing
   Wang, Shuai
   Wang, Xilian
TI Effect and Mechanism of Endothelin Receptor A Inhibitor BQ-123 Combined with 
SO Disease markers
LA English
DT Journal Article
AB OBJECTIVE: To research the impact and mechanism of endothelin receptor A 
   inhibitor BQ-123 combined with electroacupuncture on tibia cancer pain in rats. 
   METHODS: Sprague-Dawley (SD) rats were randomly divided into sham group (SHAM 
   group) and bone cancer pain model group (BCP group). The behavior of SD rats was 
   measured. The histology of the right tibia was observed by hematoxylin-eosin (HE) 
   staining. The remaining rats were randomly divided into model, BQ-123, 
   electroacupuncture, and BQ-123+ electroacupuncture group. Behavioral tests were 
   performed, and mechanical pain threshold (MWT) and thermal pain threshold (TWL) 
   were measured. The expressions of α-smooth muscle actin (αSMA), ETAR (endothelin 
   A receptor), ETB (End of Transmission Block), P-Phosphatidylinositol 3-kinase 
   (PI3K), and P-Protein kinase B (Akt) were detected by real-time fluorescence 
   quantitative PCR and western blot. RESULTS: In the BCP group, bone structure was 
   severely damaged, local tissue swelling was obvious, bone trabecula was missing, 
   and bone cortex was discontinuous. The optical density of Glial fibrillary acidic 
   protein (GFAP) and CD11b immunoreactive signal in BCP group was significantly 
   increased, and most of the ETAR of endothelin receptor was comapped with NeuN, 
   and a small part of GFAP was comapped with CD11b, but no comapped with CD11b. The 
   AS score of BQ-123+ electroacupuncture group was significantly lower than that of 
   BQ-123 group and electroacupuncture group (P < 0.05), whereas the MWT and TWL 
   values were significantly higher than that of the BQ-123 group and 
   electroacupuncture group (P < 0.05). The mRNA expression of α-SMA and ETAR in 
   BQ-123+ electroacupuncture group was lower than that in BQ-123 and 
   electroacupuncture group, and the protein expression of P-PI3K and P-Akt in 
   BQ-123+ electroacupuncture group was lower as well. CONCLUSION: BQ-123 may 
   inhibit the activation of PI3K/Akt signal path combined with electroacupuncture 
   to alleviate the effects of tibia cancer pain in rats.
C1 The First Affiliated Hospital, Department of Pain, Hengyang Medical School, University of South China, 421001, China.
   The First Affiliated Hospital, Department of Emergency, Hengyang Medical School, University of South China, 421001, China.
   The First Affiliated Hospital, Department of Pathology, Hengyang Medical School, University of South China, 421001, China.
   The First Affiliated Hospital, Department of Rehabilitation, Hengyang Medical School, University of South China, 421001, China.
   The First Affiliated Hospital, Department of Hand Foot Surgery, Hengyang Medical School, University of South China, 421001, China.
   The First Affiliated Hospital, Department of Pain, Hengyang Medical School, University of South China, 421001, China.
NR 0
TC 0
SN 1875-863
EI 0278-024
J9 Dis Markers
PD MAY 28
PY 2022
VL 2022
IS 
BP 8563202
EP 8563202
DI 10.1155/2022/8563202 
PG 0
WC Animals; Cancer Pain; Electroacupuncture; Humans; Neoplasms; Peptides, Cyclic; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; genetics; Tibia; metabolism
UT PubMed:35620269
PM 35620269
DA 2022-05-28
ER

PT J
AU Yang, X
   Liang, B
   Xue, D
   Liang, J
   Zaslawski, C
   Chen, J
AF Yang, Xia
   Liang, Bing
   Xue, Demin
   Liang, Jing
   Zaslawski, Chris
   Chen, Ji
TI Global research trends in acupuncture for cancer pain: A bibliometric analysis.
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: In recent years, acupuncture has gained popularity in the management 
   of cancer-related pain (CRP). This study aims to use bibliometric analysis to 
   investigate the historical development, recent hotspots and research trends in 
   this field. METHODS: The Web of Science Core Collection database was selected as 
   the data source for this study to retrieve and obtain literature related to 
   acupuncture and CRP. Data analyses were performed with CiteSpace and VOSviewer to 
   conduct the bibliometric analysis. RESULTS: This bibliometric analysis was 
   conducted from 2000 to 2022. A total of 664 publications were included in this 
   work. The number of publications has steadily increased over the last 2 decades. 
   The United States has the largest number of published articles (244 papers), 
   while the People's Republic of China has the highest centrality (0.48). The 
   primary research institutions were Memorial Sloan-Kettering Cancer Center, Kyung 
   Hee University and Beijing University of Chinese Medicine. Mao Jun J. was the 
   most prolific author, while Heather Greenlee was the most cited one. The most 
   productive journal was Integrative Cancer Therapies. The most frequent keywords 
   excluding the search subject were "electroacupuncture," "management," "quality of 
   life," "breast cancer," "Aromatase inhibitor," "neuropathic pain," "mechanisms," 
   and "protocol." CONCLUSION: This study explored the application value of 
   acupuncture in the management of CRP with bibliometric analysis, offering an 
   intuitive understanding of this topic and revealing the hotspots and research 
   trends.
C1 Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   School of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   School of Foreign Languages, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Faculty of Science, University of Technology, Sydney, New South Wales, Australia.
   School of Foreign Languages, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD OCT 13
PY 2023
VL 102
IS 41
BP e34739
EP e34739
DI 10.1097/MD.0000000000034739 
PG 1
WC Humans; Cancer Pain; therapy; Quality of Life; Acupuncture Therapy; Electroacupuncture; Bibliometrics; Neoplasms; complications
UT PubMed:37832094
PM 37832094
DA 2023-10-13
ER

PT J
AU Lu, L
   Liao, M
   Zeng, J
   He, J
AF Lu, Liming
   Liao, Muxi
   Zeng, Jingchun
   He, Jun
TI Quality of reporting and its correlates among randomized controlled trials on 
SO Expert review of anticancer therapy
LA English
DT Review
AB This study aims to analyze the quality of reporting and its correlates in 
   randomized controlled trials (RCTs) on acupuncture for cancer pain. Quality of 
   reporting for included papers was assessed against a subset of criteria adapted 
   from the CONSORT 2010 statement and STRICTA. An overall quality score (OQS) and a 
   combined key methodologic index score (MIS) was calculated for each trial. 
   Factors associated with OQS and MIS were then identified. A total of 32 RCTs were 
   included in the full text. The median OQS based on the CONSORT Statement and 
   STRICTA was 4.0 and 0, respectively. The significant predictors for CONSORT OQS 
   were year of publication and nationality of authors, for STRICTA it was 
   nationality of authors and for MIS it was publication language. The quality of 
   reporting in RCTs on acupuncture for cancer pain was poor. This indicates that 
   RCTs on acupuncture for cancer pain need substantial improvement.
C1 Faculty of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
NR 0
TC 0
SN 1744-832
EI 
J9 Expert Rev Anticancer Ther
PD APR 9
PY 2013
VL 13
IS 4
BP 489
EP 98
DI 10.1586/era.13.27 
PG -391
WC Acupuncture Therapy; Humans; Neoplasms; complications; Outcome Assessment, Health Care; standards; Pain; etiology; Publishing; standards; Quality Improvement; Randomized Controlled Trials as Topic
UT PubMed:23560843
PM 23560843
DA 2013-04-09
ER

PT J
AU He, Y
   Zhang, H
   Li, Y
   Long, S
   Xiao, S
   May, BH
   Lin, Zhang A
   Guo, X
   Xue, CC
   Lu, C
AF He, Yihan
   Zhang, Haibo
   Li, Yifang
   Long, Shunqin
   Xiao, Shujing
   May, Brian H
   Lin Zhang, Anthony
   Guo, Xinfeng
   Xue, Charlie Changli
   Lu, Chuanjian
TI Acupuncture combined with opioids for cancer pain: a pilot pragmatic randomized 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE acupuncture; cancer pain; pharmacological analgesics; pragmatic trial
AB OBJECTIVE: Given the existing evidence for the analgesic effect of acupuncture, 
   the current study aimed to assess whether acupuncture could be feasible and 
   manageable as an adjunctive therapy for cancer pain in a real-world hospital 
   setting. METHODS: Thirty patients in an Oncology department with moderate or 
   severe pain were recruited and randomized to an adjunctive acupuncture group or 
   control group, who received pharmacotherapy for pain management without 
   acupuncture. The duration of the treatment course was 1 week with a 2-week 
   follow-up. In total, four acupuncture sessions were administered, on days 1/2/4/6 
   of the trial. Pain intensity was measured using a numerical rating scale (NRS) 
   and the daily opioid dose was recorded. RESULTS: The overall trends favored 
   acupuncture for both pain intensity and daily opioid consumption. The proportion 
   of participants experiencing at least a 2-point reduction in the NRS at the end 
   of the treatment was 93% (n = 14/15) for the acupuncture group and 57% (n = 8/14) 
   for the control group (risk difference (RD) 36.1%, 95% confidence interval (CI) 
   [7.4%-65.0%]; relative risk (RR) 1.63, 95% CI [1.02-2.62]; p = 0.04). There were 
   no serious adverse events and no dropouts during the treatment. CONCLUSION: This 
   pilot study showed that adding acupuncture to routine analgesia for patients with 
   cancer pain was feasible and acceptable to patients. The clinical effects of 
   adding acupuncture as an adjunctive therapy need to be further evaluated. 
   CLINICAL TRIAL REGISTRATION NUMBER: ChiCTR1800017023 (Chinese Clinical Trial 
   Registry).
C1 China-Australia International Research Centre for Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital ofGuangzhou University of Chinese Medicine, Guangdong Provincial Academy of ChineseMedical Sciences, Guangzhou, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, GuangdongProvincial Academy of Chinese Medical Sciences, Guangzhou, China.
   Department of Traditional Therapy, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of ChineseMedicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou,China.
   Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, GuangdongProvincial Academy of Chinese Medical Sciences, Guangzhou, China.
   Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, GuangdongProvincial Academy of Chinese Medical Sciences, Guangzhou, China.
   China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.
   China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.
   China-Australia International Research Centre for Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital ofGuangzhou University of Chinese Medicine, Guangdong Provincial Academy of ChineseMedical Sciences, Guangzhou, China.
   China-Australia International Research Centre for Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital ofGuangzhou University of Chinese Medicine, Guangdong Provincial Academy of ChineseMedical Sciences, Guangzhou, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   China-Australia International Research Centre for Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital ofGuangzhou University of Chinese Medicine, Guangdong Provincial Academy of ChineseMedical Sciences, Guangzhou, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, China.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD NOV 11
PY 2021
VL 40
IS 2
BP 133
EP 141
DI 10.1177/09645284211056016 
PG 8
WC Acupuncture Therapy; Analgesics, Opioid; therapeutic use; Cancer Pain; drug therapy; Humans; Neoplasms; complications; Pain Management; Pilot Projects
UT PubMed:34755569
PM 34755569
DA 2021-11-11
ER

PT J
AU Running, A
   Seright, T
AF Running, Alice
   Seright, Teresa
TI Integrative oncology: managing cancer pain with complementary and alternative 
SO Current pain and headache reports
LA English
DT Review
AB For the projected 1,638,910 patients with a diagnosis of cancer this year, the 
   great majority of them (75-90 %) will experience cancer-related pain. A growing 
   number of these patients will turn to complementary and alternative therapies to 
   assist with the management of their pain and other cancer-related symptoms. The 
   World Health Organization's suggested approach to pain management begins with the 
   use of time honored opioids, but recommends the use of adjuvant therapies early 
   in the management process. Complementary and alternative therapies are being used 
   by more patients each year to assist with the management of their pain. 
   Practitioners and researchers must be aware of the evidence that exists to 
   support or refute the use of these therapies. In this manuscript we review 
   evidence from the recent past on complementary and alternative therapies for pain 
   with emphasis on more common modalities including acupuncture, bio-energy, 
   massage, and music.
C1 College of Nursing, Montana State University, Bozeman, MT 59717-3560, USA. alice.running@montana.edu
NR 0
TC 0
SN 1534-308
EI 
J9 Curr Pain Headache Rep
PD MAY 29
PY 2012
VL 16
IS 4
BP 325
EP 31
DI 10.1007/s11916-012-0275-x 
PG -294
WC Acupuncture Therapy; Anxiety; diagnosis; Combined Modality Therapy; Complementary Therapies; methods; Evidence-Based Medicine; Female; Holistic Health; Humans; Male; Massage; Meditation; Music Therapy; Neoplasms; complications; Pain; diagnosis; Pain Management; methods; Patient Selection; Treatment Outcome
UT PubMed:22639181
PM 22639181
DA 2012-05-29
ER

PT J
AU Zhao, YX
   Yao, MJ
   Shen, JW
   Zhang, WX
   Zhou, YX
AF Zhao, Yu-Xue
   Yao, Ming-Jiang
   Shen, Jian-Wu
   Zhang, Wen-Xi
   Zhou, Yuan-Xi
TI Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer 
SO Molecular pain
LA English
DT Journal Article
DE Cancer pain; electroacupuncture; inflammatory signals; neuropeptide
AB Pain is a major symptom in cancer patients, and cancer-induced bone pain (CIBP) 
   is the most common type of moderate and severe cancer-related pain. The current 
   available analgesic treatments for CIBP have adverse effects as well as limited 
   therapeutic effects. Acupuncture is proved effective in pain management as a safe 
   alternative therapy. We evaluated the analgesic effect of acupuncture in 
   treatment of cancer pain and try to explore the underlying analgesic mechanisms. 
   Nude mice were inoculated with cancer cells into the left distal femur to 
   establish cancer pain model. Electroacupuncture (EA) treatment was applied for 
   the xenograft animals. Pain behaviors of mice were evaluated, followed by the 
   detections of neuropeptide-related and inflammation-related indicators in 
   peripheral and central levels. EA treatment alleviated cancer-induced pain 
   behaviors covering mechanical allodynia, thermal hyperalgesia and spontaneous 
   pain, and also down-regulated immunofluorescence expressions of neuropeptide CGRP 
   and p75 in the skin of affected plantar area in xenograft mice, and inhibited 
   expressions of overexpressed neuropeptide-related and inflammation-related 
   protein in the lumbar spinal cord of xenograft mice. Overall, our findings 
   suggest that EA treatment ameliorated cancer-induced pain behaviors in the mouse 
   xenograft model of cancer pain, possibly through inhibiting the expressions of 
   neuropeptide-related and inflammation-related protein in central level following 
   tumor cell xenografts.
C1 Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences , Beijing, China. RINGGOLD: 535285
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences , Beijing, China. RINGGOLD: 535285
   Institute of Basic Medical Sciences, Xiyuan Hospital of China Academy of Chinese 
   Key Laboratory of Pharmacology of Chinese Materia Medica, Beijing, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences , Beijing, China. RINGGOLD: 535285
   Urology Department of Xiyuan Hospital, Xiyuan Hospital of China Academy of 
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences , Beijing, China. RINGGOLD: 535285
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences , Beijing, China. RINGGOLD: 535285
NR 0
TC 0
SN 1744-806
EI 
J9 Mol Pain
PD MAR 6
PY 2024
VL 20
IS 
BP 17448069241240692
EP 17448069241240692
DI 10.1177/17448069241240692 
PG 1
WC Rats; Humans; Mice; Animals; Cancer Pain; etiology; Electroacupuncture; Nociception; Mice, Nude; Rats, Sprague-Dawley; Pain; metabolism; Hyperalgesia; complications; Analgesics; metabolism; Neoplasms; Inflammation; metabolism; Neuropeptides; Spinal Cord; metabolism
UT PubMed:38443317
PM 38443317
DA 2024-03-06
ER

PT J
AU Wang, Y
   Yan, T
   Mu, X
   Dong, H
   Su, J
AF Wang, Yan
   Yan, Tingquan
   Mu, Xiaojing
   Dong, Hong
   Su, Jinman
TI Effects of Moxibustion Combined with Ultrashort Wave on Pain and Oxidative Stress 
SO Computational and mathematical methods in medicine
LA English
DT Journal Article
AB OBJECTIVE: To explore the effect of moxibustion instrument combined with 
   ultrashort wave on pain and oxidative stress in elderly patients with knee 
   osteoarthritis (KOA). METHOD: 84 elderly patients with knee osteoarthritis 
   treated in our hospital from May 2020 to June 2021 were randomly divided into 
   observation group (n = 42) and control group (n = 42). The observation group was 
   treated with moxibustion instrument combined with ultrashort wave, while the 
   control group was treated with moxibustion instrument. The clinical efficacy of 
   the two groups was compared, and the pain of the two groups was evaluated by 
   visual analogue scale (VAS). Lysholm knee joint score scale and osteoarthritis 
   index (WOMAC) scale of Western Ontario and McMaster University were used to 
   evaluate the knee joint function of the two groups, and the levels of 
   interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α), serum superoxide 
   dismutase (SOD), serum malondialdehyde (MDA), serum miR-155, and NLRP3 were 
   detected in the two groups, and the comprehensive quality of life assessment 
   questionnaire-74 was used, and the adverse reactions were compared between the 
   two groups. RESULTS: The total effective rate of observation group (90.48%) was 
   higher than that of control group (69.05%) (P < 0.05). After treatment, VAS, 
   Lysholm knee joint, WOMAC, quality of life scores, IL-1β, TNF-α, SOD, MDA, 
   miR-155, and NLRP3 in the observation group were better than those in the control 
   group, and the differences were statistically significant (P < 0.05). There were 
   no obvious adverse reactions in both groups. Conclusion. Moxibustion instrument 
   combined with ultrashort wave can effectively improve knee joint pain, knee joint 
   function, inflammatory reaction, oxidative stress reaction, and quality of life 
   in elderly KOA patients, and the therapeutic effect is good.
C1 First Outpatient Department, 971st Hospital, People's Liberation Army Navy, Qingdao, Shandong 266071, China.
   First Outpatient Department, 971st Hospital, People's Liberation Army Navy, Qingdao, Shandong 266071, China.
   First Outpatient Department, 971st Hospital, People's Liberation Army Navy, Qingdao, Shandong 266071, China.
   First Outpatient Department, 971st Hospital, People's Liberation Army Navy, Qingdao, Shandong 266071, China.
   Ten Branches of Recuperation, Navy Qingdao Special Service Convalescent Center, Qingdao, Shandong 266071, China.
NR 0
TC 0
SN 1748-671
EI 1748-670
J9 Comput Math Methods Med
PD MAY 20
PY 2022
VL 2022
IS 
BP 3921021
EP 3921021
DI 10.1155/2022/3921021 
PG 0
WC Age Factors; Aged; Humans; Knee Joint; MicroRNAs; Moxibustion; NLR Family, Pyrin Domain-Containing 3 Protein; Osteoarthritis, Knee; metabolism; Oxidative Stress; Pain; etiology; Pain Management; Quality of Life; Superoxide Dismutase; metabolism; Treatment Outcome; Tumor Necrosis Factor-alpha; metabolism; Ultrasonic Therapy
UT PubMed:35586674
PM 35586674
DA 2022-05-20
ER

PT J
AU Latchman, J
   Le, LQ
   McGuire, A
AF Latchman, Jessica
   Le, Liem Q
   McGuire, Anthony
TI Incorporating Music Therapy With Acupuncture in Managing Cancer Pain at an 
SO Clinical journal of oncology nursing
LA English
DT Journal Article
DE acupuncture; cancer; cancer-related pain; complementary medicine; music therapy
AB BACKGROUND: Complementary and alternative medicine encompasses various 
   nonpharmacologic interventions for managing pain, such as acupuncture and music 
   therapy. Few studies have combined these two interventions in the management of 
   cancer-related pain. OBJECTIVES: The purpose of this evidence-based project was 
   to compare acupuncture-only therapy versus dual therapy (acupuncture and music 
   therapy) on pain intensity scores in patients with cancer. METHODS: This 
   evidence-based project included 102 participants at a private acupuncture 
   practice. One group had acupuncture only for six weeks, and another had six weeks 
   of acupuncture and music therapy. The Numeric Pain Rating Scale was used to 
   assess pain before and after the interventions. FINDINGS: Findings showed that 
   both groups had clinically and statistically significant improvements in pain 
   intensity scores. Although a significant difference was not noted between the two 
   groups, acupuncture and music therapy were each found to be effective for 
   managing cancer-related pain.
C1 H. Lee Moffitt Cancer and Research Institute.
   University of Western States.
   University of South Florida.
NR 0
TC 0
SN 1538-067
EI 
J9 Clin J Oncol Nurs
PD JUN 3
PY 2024
VL 28
IS 3
BP 305
EP 312
DI 10.1188/24.CJON.305-312 
PG 7
WC Humans; Music Therapy; methods; Acupuncture Therapy; methods; Female; Middle Aged; Male; Cancer Pain; therapy; Aged; Adult; Pain Management; methods; Neoplasms; complications; Pain Measurement; Combined Modality Therapy; Treatment Outcome
UT PubMed:38830247
PM 38830247
DA 2024-06-03
ER

PT J
AU Choi, TY
   Lee, MS
   Kim, TH
   Zaslawski, C
   Ernst, E
AF Choi, Tae-Young
   Lee, Myeong Soo
   Kim, Tae-Hun
   Zaslawski, Christopher
   Ernst, Edzard
TI Acupuncture for the treatment of cancer pain: a systematic review of randomised 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
AB PURPOSE: Controlling cancer-related pain is an important component in the 
   palliative care of cancer patients. The objective of this review was to assess 
   the effectiveness of acupuncture for treating cancer pain. METHODS: Fourteen 
   databases were searched from their inception through April 2011. Randomised 
   clinical trials (RCTs) were included if acupuncture was used as the sole 
   treatment or as a part of a combination therapy for cancer pain. Studies were 
   included if they were controlled with a placebo or controlled against a 
   drug-therapy or no-treatment group. The Cochrane criteria were used to assess the 
   risk of bias. RESULTS: A total of 15 RCTs met our inclusion criteria. All of the 
   included RCTs were associated with a high risk of bias. The majority of 
   acupuncture treatments or combination therapies with analgesics exhibited 
   favourable effects compared with conventional treatments in individual studies. 
   However, a meta-analysis suggested that acupuncture did not generate a better 
   effect than drug therapy (n = 886; risk ratio (RR), 1.12; 95% CI 0.98 to 1.28; P 
   = 0.09). The comparison between acupuncture plus drug therapy and drug therapy 
   alone demonstrated a significant difference in favour of the combination therapy 
   (n = 437; RR, 1.36; 95% CI 1.13 to 1.64; P = 0.003). The results of this 
   systematic review provide no strong evidence for the effectiveness of acupuncture 
   in the management of cancer pain. CONCLUSION: The total number of RCTs included 
   in the analysis and their methodological quality were too low to draw firm 
   conclusions. Future rigorous RCTs will be necessary to assess the clinical 
   efficacy of acupuncture in this area.
C1 Medical Research Division, Korea Institute of Oriental Medicine, Daejeon, 305-811, South Korea.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD MAR 27
PY 2012
VL 20
IS 6
BP 1147
EP 58
DI 10.1007/s00520-012-1432-9 
PG -1089
WC Acupuncture Therapy; methods; Analgesics; administration & dosage; Combined Modality Therapy; Humans; Neoplasms; complications; Pain; etiology; Pain Management; methods; Palliative Care; methods; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:22447366
PM 22447366
DA 2012-03-27
ER

PT J
AU Garcia, MK
   McQuade, J
   Lee, R
   Haddad, R
   Spano, M
   Cohen, L
AF Garcia, M Kay
   McQuade, Jennifer
   Lee, Richard
   Haddad, Robin
   Spano, Michael
   Cohen, Lorenzo
TI Acupuncture for symptom management in cancer care: an update.
SO Current oncology reports
LA English
DT Journal Article
AB In a previous systematic review of the worldwide literature of randomized 
   controlled trials (RCTs) involving needle insertion into acupuncture points for 
   symptom management in cancer patients, we identified only one high-quality RCT 
   that was deemed to have a low risk of bias. Medline, Embase, CINAHL, Cochrane 
   (all databases), Scopus, and PubMed were searched from inception through December 
   2011 with no language limits applied. A total of 41 RCTs met all inclusion 
   criteria and were rated. In the current review, we examined 18 trials published 
   since our last report. The purpose of this update was to emphasize important 
   recent findings and discuss how concerns such as blinding, separating 
   non-specific placebo effects from specific needling effects, determining biologic 
   mechanisms and dosing parameters, evaluating determinants of response such as 
   expectation, controlling for sources of bias, and the lack of standardization in 
   treatment and study methods may affect the interpretation of study results.
C1 Department of General Oncology, Integrative Medicine Program, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 0462, Houston, TX,77030, USA, kaygarcia@mdanderson.org.
NR 0
TC 0
SN 1534-626
EI 
J9 Curr Oncol Rep
PD OCT 19
PY 2014
VL 16
IS 12
BP 418
EP 418
DI 10.1007/s11912-014-0418-9 
PG 0
WC Acupuncture Therapy; Antineoplastic Agents; administration & dosage; Arthralgia; chemically induced; Evidence-Based Medicine; Fatigue; etiology; Hot Flashes; etiology; Humans; Nausea; etiology; Neoplasms; complications; Randomized Controlled Trials as Topic; Treatment Outcome; Xerostomia; chemically induced
UT PubMed:25325937
PM 25325937
DA 2014-10-19
ER

PT J
AU Yang, J
   Xu, G
   Yin, Z
   Cheng, Y
   Sun, SM
   Zheng, Q
   Chen, J
   Liang, FR
   Zhao, L
AF Yang, Jiao
   Xu, Guixing
   Yin, Zihan
   Cheng, Ying
   Sun, Sheng Ming
   Zheng, Qianhua
   Chen, Jiao
   Liang, Fan-Rong
   Zhao, Ling
TI Acupuncture for chronic cancer-related pain: a systematic review and network 
SO BMJ open
LA English
DT Journal Article
DE anaesthesia in oncology; complementary medicine; pain management
AB INTRODUCTION: Chronic cancer-related pain is one of the most common excruciating 
   symptom that can be caused by the cancer (by the primary tumour or by metastases) 
   or by its treatment (surgery, chemotherapy and radiotherapy). Although multiple 
   clinical trials and systematic reviews have suggested that acupuncture could be 
   effective in treating chronic cancer-related pain, the comparative efficacy and 
   safety of these acupuncture methods remains unclear. We, therefore, performed 
   this study to evaluate and rank the efficacy and safety of different acupuncture 
   methods for chronic cancer-related pain. METHODS AND ANALYSIS: Seven databases 
   will be searched, including Cochrane Library, MEDLINE, Embase, Chinese National 
   Knowledge Infrastructure (CNKI), Wanfang Database, the Chongqing VIP Chinese 
   Science and Technology Periodical Database and Chinese Biomedical Literature 
   Database (CBM) from their inception to March 2020. The primary outcome is the 
   change of pain intensity. Bayesian network meta-analysis will be conducted using 
   software R3.5.1. Finally, we will use the Grading of Recommendations Assessment, 
   Development and Evaluation System (GRADE) to assess the quality of evidence. 
   ETHICS AND DISSEMINATION: Ethical approval is not required for literature-based 
   studies. The results will be disseminated through peer-reviewed publication. 
   PROSPERO REGISTRATION NUMBER: CRD42020165747.
C1 Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China acuresearch@126.com zhaoling@cdutcm.edu.cn.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China acuresearch@126.com zhaoling@cdutcm.edu.cn.
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD OCT 10
PY 2020
VL 10
IS 10
BP e039087
EP e039087
DI 10.1136/bmjopen-2020-039087 
PG 1
WC Acupuncture Therapy; Bayes Theorem; Cancer Pain; etiology; Chronic Pain; etiology; Humans; Neoplasms; complications; Systematic Reviews as Topic; Network Meta-Analysis as Topic
UT PubMed:33033027
PM 33033027
DA 2020-10-10
ER

PT J
AU Garcia, MK
   McQuade, J
   Haddad, R
   Patel, S
   Lee, R
   Yang, P
   Palmer, JL
   Cohen, L
AF Garcia, M Kay
   McQuade, Jennifer
   Haddad, Robin
   Patel, Sonya
   Lee, Richard
   Yang, Peiying
   Palmer, J Lynn
   Cohen, Lorenzo
TI Systematic review of acupuncture in cancer care: a synthesis of the evidence.
SO Journal of clinical oncology : official journal of the American Society of 
LA English
DT Journal Article
AB PURPOSE: Many cancer centers offer acupuncture services. To date, a comprehensive 
   systematic review of acupuncture in cancer care has not been conducted. The 
   purpose of this review was to evaluate the efficacy of acupuncture for symptom 
   management in patients with cancer. METHODS: Medline, Embase, CINAHL, Cochrane 
   (all databases), Scopus, and PubMed were searched from inception through December 
   2011 for prospective randomized clinical trials (RCT) evaluating acupuncture for 
   symptom management in cancer care. Only studies involving needle insertion into 
   acupuncture points were included. No language limitations were applied. Studies 
   were assessed for risk of bias (ROB) according to Cochrane criteria. Outcomes by 
   symptom were designated as positive, negative, or unclear. RESULTS: A total of 
   2,151 publications were screened. Of those, 41 RCTs involving eight symptoms 
   (pain, nausea, hot flashes, fatigue, radiation-induced xerostomia, prolonged 
   postoperative ileus, anxiety/mood disorders, and sleep disturbance) met all 
   inclusion criteria. One positive trial of acupuncture for chemotherapy-induced 
   nausea and vomiting had low ROB. Of the remaining studies, eight had unclear ROB 
   (four positive, three negative, and one with unclear outcomes). Thirty-three 
   studies had high ROB (19 positive, 11 negative, and three with both positive and 
   negative outcomes depending on the symptom). CONCLUSION: Acupuncture is an 
   appropriate adjunctive treatment for chemotherapy-induced nausea/vomiting, but 
   additional studies are needed. For other symptoms, efficacy remains undetermined 
   owing to high ROB among studies. Future research should focus on standardizing 
   comparison groups and treatment methods, be at least single-blinded, assess 
   biologic mechanisms, have adequate statistical power, and involve multiple 
   acupuncturists.
C1 University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 0462, Houston, TX 77030, USA.
NR 0
TC 0
SN 1527-775
EI 0732-183
J9 J Clin Oncol
PD JAN 24
PY 2013
VL 31
IS 7
BP 952
EP 60
DI 10.1200/JCO.2012.43.5818 
PG -892
WC Acupuncture Therapy; Antineoplastic Agents; administration & dosage; Anxiety; etiology; Evidence-Based Medicine; Fatigue; etiology; Hot Flashes; etiology; Humans; Intestinal Pseudo-Obstruction; etiology; Mood Disorders; etiology; Nausea; etiology; Neoplasms; complications; Observer Variation; Pain; etiology; Pain Management; methods; Radiotherapy; adverse effects; Randomized Controlled Trials as Topic; Sleep Wake Disorders; etiology; Treatment Outcome; Xerostomia; etiology
UT PubMed:23341529
PM 23341529
DA 2013-01-24
ER

PT J
AU Hershman, DL
   Loprinzi, C
   Schneider, BP
AF Hershman, Dawn L
   Loprinzi, Charles
   Schneider, Bryan P
TI Symptoms: Aromatase Inhibitor Induced Arthralgias.
SO Advances in experimental medicine and biology
LA English
DT Review
AB Recent clinical trials have demonstrated that aromatase inhibitors (AIs) are 
   slightly more effective than tamoxifen at reducing breast cancer recurrences. 
   However, breast cancer patients receiving AIs have a higher incidence of 
   musculoskeletal symptoms, particularly joint pain and stiffness. Musculoskeletal 
   pain and stiffness can lead to noncompliance and increased utilization of health 
   care resources. There is a suggestion that the syndrome is the result of estrogen 
   deprivation and may share components with autoimmune diseases such as Sjögren's 
   syndrome. Several factors may increase the likelihood of developing AI 
   arthralgia, such as prior chemotherapy, prior hormone replacement therapy, and 
   increased weight; there are inconsistencies with regard to the data on genetic 
   predispositions to this syndrome. While several studies have been done to 
   evaluate interventions to treat or prevent AI arthralgia, no clear treatment has 
   emerged as being particularly beneficial. Much of the research has been limited 
   by small sample size, difficulty blinding patients to placebo, inconsistent 
   definitions of the syndrome, multiple patient reported outcomes, lack of 
   objective outcome measures and heterogeneous patient populations. We are at the 
   early stages of research in characterizing, understanding etiology, preventing 
   and treating AI arthralgias; however much work is being done in this area which, 
   hopefully, will ultimately improve the lives of women with breast cancer.
C1 Medicine and Epidemiology, Herbert Irving Comprehensive Cancer Center, Columbia University, 161 Fort Washington, 1068, New York, NY, 10032, USA,dlh23@cumc.columbia.edu.
NR 0
TC 0
SN 
EI 0065-259
J9 Adv Exp Med Biol
PD JUN 11
PY 2015
VL 862
IS 
BP 89
EP 100
DI 10.1007/978-3-319-16366-6_7 
PG 11
WC Acupuncture Therapy; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Chondroitin; therapeutic use; Female; Glucosamine; therapeutic use; Humans; Risk Factors; Vitamin D Deficiency; complications
UT PubMed:26059931
PM 26059931
DA 2015-06-11
ER

PT J
AU Paley, CA
   Tashani, OA
   Bagnall, AM
   Johnson, MI
AF Paley, Carole A
   Tashani, Osama A
   Bagnall, Anne-Marie
   Johnson, Mark I
TI A Cochrane systematic review of acupuncture for cancer pain in adults.
SO BMJ supportive & palliative care
LA English
DT Journal Article
AB BACKGROUND: Cancer-related pain is a significant and debilitating problem. 
   Non-pharmacological treatments such as acupuncture may have an adjunctive role in 
   controlling pain without the undesirable side effects of drug regimens and yet 
   the evidence base remains limited. OBJECTIVES: The main objective of this 
   systematic review was to evaluate the effectiveness of acupuncture in the 
   management of cancer-related pain in adults. Subgroup analyses were planned for 
   acupuncture dose and for the outcome of studies investigating acupuncture for 
   cancer-induced bone pain. METHODS: Six electronic databases were searched, 
   including the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, 
   PsycINFO, AMED and SPORTDiscus. Studies included in the review were randomised 
   controlled trials investigating the use of acupuncture for cancer pain using pain 
   as a primary outcome measure. In total, 253 published references were identified 
   but only three studies met the inclusion criteria and were included in the final 
   review. RESULTS: Of the three included studies, only one was judged to be of high 
   methodological quality and showed auricular acupuncture to be superior to placebo 
   acupuncture and ear seeds at placebo points. However, the study was relatively 
   small and blinding was compromised. The two low-quality studies gave positive 
   results in favour of acupuncture for cancer pain, but these results should be 
   viewed with caution due to methodological limitations, small sample sizes, poor 
   reporting and inadequate analysis. CONCLUSION: There is insufficient evidence to 
   judge whether acupuncture is effective in treating cancer pain in adults.
C1 Research & Effectiveness Department, Airedale NHS Foundation Trust, Steeton, Keighley, UK.
NR 0
TC 0
SN 2045-436
EI 
J9 BMJ Support Palliat Care
PD JUN 1
PY 2011
VL 1
IS 1
BP 51
EP 5
DI 10.1136/bmjspcare-2011-000022 
PG -46
WC Acupuncture Therapy; methods; Acupuncture, Ear; methods; Adult; Humans; Neoplasms; complications; Pain; etiology; Pain Management; methods; Treatment Outcome
UT PubMed:24653050
PM 24653050
DA 2011-06-01
ER

PT J
AU Ledford, C
AF Ledford, Christopher
TI Spine Conditions: Mechanical and Inflammatory Low Back Pain.
SO FP essentials
LA English
DT Review
AB Mechanical low back pain (LBP) is an injury or derangement of an anatomic 
   structure in the low back. When evaluating patients with LBP, clinicians should 
   maintain clinical suspicion for vertebral fracture, cancer, and cauda equina 
   syndrome. Management includes patient education focused on exercise, massage, and 
   behavioral approaches such as cognitive behavioral therapy. Acupuncture can be an 
   effective alternative and specific herbal supplements may provide short-term pain 
   relief. The prognosis for patients with mechanical LBP is good. Inflammatory LBP 
   is pain resulting from a systemic inflammatory condition, often referred to as 
   axial spondyloarthritis. Ankylosing spondylitis is chronic inflammatory LBP 
   characterized by early onset (mean age 24 years), with a higher prevalence in 
   men. Five clinical parameters can help identify inflammatory LBP: improvement 
   with exercise, pain at night, insidious onset, onset at younger than 40 years, 
   and no improvement with rest. Management of inflammatory LBP typically includes 
   nonsteroidal anti-inflammatory drugs and structured exercise programs, with 
   emphasis on the involvement of a rheumatology subspecialist. Spondyloarthritis is 
   associated with other rheumatic or autoimmune conditions, including rheumatoid 
   arthritis, inflammatory bowel disease, and psoriasis. These should be considered 
   when evaluating patients with inflammatory LBP.
C1 Eglin Air Force Base Family Medicine Residency, 307 Boatner Rd, Eglin AFB, FL 32542.
NR 0
TC 0
SN 
EI 2159-300
J9 FP Essent
PD OCT 12
PY 2017
VL 461
IS 
BP 15
EP 20
DI 
PG 5
WC Acupuncture Therapy; Anti-Inflammatory Agents, Non-Steroidal; therapeutic use; Back Injuries; diagnosis; Cognitive Behavioral Therapy; Exercise Therapy; Herbal Medicine; Humans; Low Back Pain; diagnosis; Pain Management; Physical Therapy Modalities; Prognosis; Spondylarthropathies; diagnosis
UT PubMed:29019640
PM 29019640
DA 2017-10-12
ER

PT J
AU Gao, Y
   Ma, T
   Han, M
   Yu, M
   Wang, X
   Lv, Y
   Wang, X
AF Gao, Yu
   Ma, Tingting
   Han, Mei
   Yu, Mingwei
   Wang, Xiuhui
   Lv, Yiren
   Wang, Xiaomin
TI Effects of Acupuncture and Moxibustion on Breast Cancer-Related Lymphedema: A 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; breast cancer-related lymphedema; moxibustion
AB OBJECTIVE: The aim of this systematic review and meta-analysis of randomized 
   controlled trials (RCTs) was to evaluate the effects of acupuncture and 
   moxibustion (AM) in women with breast cancer-related lymphedema (BCRL). METHODS: 
   We retrieved RCTs published before January 24, 2021, from the MEDLINE, EMBASE, 
   Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), 
   Chongqing VIP (VIP), and Wanfang databases. RCTs that compared acupuncture and/or 
   moxibustion intervention with other treatments were included. A random effects or 
   fixed effects model was used based on the heterogeneity findings. Study quality 
   was evaluated using the Cochrane risk of bias tool. RESULTS: We included 14 RCTs 
   in the analyses, of which 4 RCTs adopted acupuncture, 4 RCTs used moxibustion, 
   and the rest used both. AM significantly reduced arm circumference at the elbow 
   crease compared to routine care (Mean deviation (MD) = -7.26, 95% confidence 
   interval (CI) = -8.30 to -6.21, P < .00001). There was a significant difference 
   between AM and diosmin tablets in the effective index for upper limb lymphedema 
   (MD = 24.68, 95% CI = 24.82-30.53, P < .00001), the range of motion of the 
   shoulder during protraction (MD = 6.77, 95% CI = 2.81-10.73, P = .0008), and 
   adduction (MD = 4.17, 95% CI = 1.02-7.32, P = .01). There was a significant 
   difference between moxibustion and pneumatic circulation (MD = -0.51, 95% 
   CI = -0.85 to -0.17, P = .003) in the visual analog score (VAS) for swelling. 
   Finally, compared to the blank control, acupuncture reduced the VAS for pain 
   (MD = -1.33, 95% CI = -1.52 to -1.15, P < .00001; heterogeneity (I(2)) = 0%, 
   P = .57). CONCLUSION: Our results suggest that AM is effective in the treatment 
   of BCRL. AM may reduce arm circumference at the elbow crease (compared to routine 
   care), increase effective index for upper limb lymphedema (compared to oral 
   diosmin tablets), improve the range of motion of the shoulder during protraction 
   and adduction (compared to oral diosmin tablets), and decrease the VAS for both 
   swelling (compared to pneumatic circulation) and pain (compared to blank 
   control).
C1 Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
   Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
   Beijing University of Chinese Medicine, Beijing, China.
   Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
   Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
   Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
   Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD SEP 16
PY 2021
VL 20
IS 
BP 15347354211044107
EP 15347354211044107
DI 10.1177/15347354211044107 
PG 1
WC Acupuncture Therapy; Breast Neoplasms; complications; Female; Humans; Lymphedema; etiology; Moxibustion; Randomized Controlled Trials as Topic
UT PubMed:34521235
PM 34521235
DA 2021-09-16
ER

PT J
AU Hershman, DL
   Unger, JM
   Greenlee, H
   Capodice, J
   Lew, DL
   Darke, A
   Minasian, LM
   Fisch, MJ
   Henry, NL
   Crew, KD
AF Hershman, Dawn L
   Unger, Joseph M
   Greenlee, Heather
   Capodice, Jillian
   Lew, Danika L
   Darke, Amy
   Minasian, Lori M
   Fisch, Michael J
   Henry, N Lynn
   Crew, Katherine D
TI Comparison of Acupuncture vs Sham Acupuncture or Waiting List Control in the 
SO JAMA network open
LA English
DT Journal Article
AB IMPORTANCE: Aromatase inhibitors (AIs) have proven efficacy for the treatment of 
   hormone-sensitive breast cancer; however, arthralgias (pain and stiffness) 
   contribute to nonadherence with therapy for more than 50% of patients. OBJECTIVE: 
   To examine the effect of acupuncture in reducing AI-related joint pain through 52 
   weeks. DESIGN, SETTING, AND PARTICIPANTS: A randomized clinical trial was 
   conducted at 11 sites in the US from May 1, 2012, to February 29, 2016, with a 
   scheduled final date of follow-up of September 5, 2017, to compare true 
   acupuncture (TA) with sham acupuncture (SA) or waiting list control (WC). Women 
   with early-stage breast cancer were eligible if they were taking an AI and scored 
   3 or higher on the Brief Pain Inventory Worst Pain (BPI-WP) item (score range, 
   0-10; higher scores indicate greater pain). Analysis was conducted for data 
   received through May 3, 2021. INTERVENTIONS: Participants were randomized 2:1:1 
   to the TA (n = 110), SA (n = 59), or WC (n = 57) group. The TA and SA protocols 
   were composed of 6 weeks of intervention at 2 sessions per week (12 sessions 
   overall), followed by 6 additional weeks of intervention with 1 session per week. 
   Participants randomized to WC received no intervention. All participants were 
   offered 10 acupuncture sessions to be used between weeks 24 and 52. MAIN OUTCOMES 
   AND MEASURES: In this long-term evaluation, the primary end point was the 52-week 
   BPI-WP score, compared by study group using linear regression, adjusted for 
   baseline pain and stratification factors. RESULTS: Among 226 randomized women 
   (mean [SD] age, 60.7 [8.6] years; 87.7% White; mean [SD] baseline BPI-WP score, 
   6.7 [1.5]), 191 (84.5%) completed the trial. In a linear regression, 52-week mean 
   BPI-WP scores were 1.08 (95% CI, 0.24-1.91) points lower in the TA compared with 
   the SA group (P = .01) and were 0.99 (95% CI, 0.12-1.86) points lower in the TA 
   compared with the WC group (P = .03). In addition, 52-week BPI pain interference 
   scores were statistically significantly lower in the TA compared with the SA 
   group (difference, 0.58; 95% CI, 0.00-1.16; P = .05). Between 24 and 52 weeks, 12 
   (13.2%) of TA, 6 (11.3%) of SA, and 5 (10.6%) of WC patients reported receipt of 
   acupuncture. CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, women 
   with AI-related joint pain receiving 12 weeks of TA had reduced pain at 52 weeks 
   compared with controls, suggesting long-term benefits of this therapy. TRIAL 
   REGISTRATION: ClinicalTrials.gov Identifier: NCT01535066.
C1 Columbia University Irving Medical Center, New York, New York.
   Fred Hutchinson Cancer Center, Seattle, Washington.
   SWOG Statistics and Data Management Center, Seattle, Washington.
   Fred Hutchinson Cancer Center, Seattle, Washington.
   Department of Urology, Mount Sinai Hospital, New York, New York.
   Fred Hutchinson Cancer Center, Seattle, Washington.
   SWOG Statistics and Data Management Center, Seattle, Washington.
   Fred Hutchinson Cancer Center, Seattle, Washington.
   SWOG Statistics and Data Management Center, Seattle, Washington.
   Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland.
   AIM Specialty Health, Chicago, Illinois.
   Department of Medicine, University of Michigan, Ann Arbor.
   Columbia University Irving Medical Center, New York, New York.
NR 0
TC 0
SN 2574-380
EI 
J9 JAMA Netw Open
PD NOV 12
PY 2022
VL 5
IS 11
BP e2241720
EP e2241720
DI 10.1001/jamanetworkopen.2022.41720 
PG 1
WC Humans; Female; Middle Aged; Aromatase Inhibitors; adverse effects; Waiting Lists; Acupuncture Therapy; methods; Arthralgia; therapy; Breast Neoplasms; complications
UT PubMed:36367721
PM 36367721
DA 2022-11-12
ER

PT J
AU Johnson, JR
   Crespin, DJ
   Griffin, KH
   Finch, MD
   Dusek, JA
AF Johnson, Jill R
   Crespin, Daniel J
   Griffin, Kristen H
   Finch, Michael D
   Dusek, Jeffery A
TI Effects of integrative medicine on pain and anxiety among oncology inpatients.
SO Journal of the National Cancer Institute. Monographs
LA English
DT Journal Article
AB BACKGROUND: Few studies have investigated the effectiveness of integrative 
   medicine (IM) therapies on pain and anxiety among oncology inpatients. METHODS: 
   Retrospective data obtained from electronic medical records identified patients 
   with an oncology International Classification of Diseases-9 code who were 
   admitted to a large Midwestern hospital between July 1, 2009 and December 31, 
   2012. Outcomes were change in patient-reported pain and anxiety, rated before and 
   after individual IM treatment sessions, using a numeric scale (0-10). RESULTS: Of 
   10948 hospital admissions over the study period, 1833 (17%) included IM therapy. 
   Older patients had reduced odds of receiving any IM therapy (odds ratio [OR]: 
   0.97, 95% confidence interval [95% CI] = 0.96 to 0.98) and females had 63% (OR: 
   1.63, 95% CI = 1.38 to 1.92) higher odds of receiving any IM therapy compared 
   with males. Moderate (OR: 1.97, 95% CI = 1.61 to 2.41), major (OR: 3.54, 95% CI = 
   2.88 to 4.35), and extreme (OR: 5.96, 95% CI = 4.71 to 7.56) illness severity 
   were significantly associated with higher odds of receiving IM therapy compared 
   with admissions of minor illness severity. After receiving IM therapy, patients 
   averaged a 46.9% (95% CI = 45.1% to 48.6%, P <.001) reduction in pain and a 56.1% 
   (95% CI = 54.3% to 58.0%, P <.001) reduction in anxiety. Bodywork and traditional 
   Chinese Medicine therapies were most effective for reducing pain, while no 
   significant differences among therapies for reducing anxiety were observed. 
   CONCLUSIONS: IM services to oncology inpatients resulted in substantial decreases 
   in pain and anxiety. Observational studies using electronic medical records 
   provide unique information about real-world utilization of IM. Future studies are 
   warranted and should explore potential synergy of opioid analgesics and IM 
   therapy for pain control.
C1 Integrative Health Research Center, Penny George Institute for Health and Healing, Allina Health, Minneapolis, MN (JRJ, KHG, JAD)
   Division of HealthPolicy and Management, University of Minnesota School of Public Health,Minneapolis, MN (DJC)
   Medical Industry Leadership Institute, Carlson School ofManagement, University of Minnesota, Minneapolis, MN (MDF).Jill.Johnson3@allina.com.
   Integrative Health Research Center, Penny George Institute for Health and Healing, Allina Health, Minneapolis, MN (JRJ, KHG, JAD)
   Division of HealthPolicy and Management, University of Minnesota School of Public Health,Minneapolis, MN (DJC)
   Medical Industry Leadership Institute, Carlson School ofManagement, University of Minnesota, Minneapolis, MN (MDF).
   Integrative Health Research Center, Penny George Institute for Health and Healing, Allina Health, Minneapolis, MN (JRJ, KHG, JAD)
   Division of HealthPolicy and Management, University of Minnesota School of Public Health,Minneapolis, MN (DJC)
   Medical Industry Leadership Institute, Carlson School ofManagement, University of Minnesota, Minneapolis, MN (MDF).
   Integrative Health Research Center, Penny George Institute for Health and Healing, Allina Health, Minneapolis, MN (JRJ, KHG, JAD)
   Division of HealthPolicy and Management, University of Minnesota School of Public Health,Minneapolis, MN (DJC)
   Medical Industry Leadership Institute, Carlson School ofManagement, University of Minnesota, Minneapolis, MN (MDF).
   Integrative Health Research Center, Penny George Institute for Health and Healing, Allina Health, Minneapolis, MN (JRJ, KHG, JAD)
   Division of HealthPolicy and Management, University of Minnesota School of Public Health,Minneapolis, MN (DJC)
   Medical Industry Leadership Institute, Carlson School ofManagement, University of Minnesota, Minneapolis, MN (MDF).
NR 0
TC 0
SN 1745-661
EI 1052-677
J9 J Natl Cancer Inst Monogr
PD MAR 10
PY 2015
VL 2014
IS 50
BP 330
EP 7
DI 10.1093/jncimonographs/lgu030 
PG -323
WC Acupressure; Acupuncture Therapy; Adult; Age Factors; Aged; Anxiety; therapy; Complementary Therapies; statistics & numerical data; Female; Humans; Inpatients; psychology; Integrative Medicine; Male; Massage; Middle Aged; Neoplasms; complications; Pain; etiology; Pain Management; methods; Retrospective Studies; Severity of Illness Index; Sex Factors
UT PubMed:25749600
PM 25749600
DA 2015-03-10
ER

PT J
AU Zhang, D
   Zhao, X
   Li, H
   Chen, W
   Liu, C
AF Zhang, Dongxu
   Zhao, Xinhua
   Li, Hongping
   Chen, Wen
   Liu, Cunzhi
TI Effect of eight different acupuncture and moxibustion therapies on breast 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture and moxibustion therapies; Arm circumference; Breast cancer-related lymphedema; Network meta-analysis; Pain
AB BACKGROUND: Breast cancer is the most prevalent cancer worldwide, and nearly 30% 
   of affected patients experience breast cancer-related lymphedema (BCRL). Some 
   evidence suggests that acupuncture and moxibustion therapies are safe and 
   effective in the treatment of BCRL. Nevertheless, there is controversy regarding 
   the optimal acupuncture and moxibustion therapy for BCRL. OBJECTIVE: The aim of 
   this study was to compare and rank the efficacy of different acupuncture and 
   moxibustion therapies for BCRL, to identify the best acupuncture and moxibustion 
   therapy for BCRL, and to provide a reference for clinicians to choose the 
   treatment modality. METHODS: We searched PubMed, Embase, Cochrane Library, Web of 
   Science, Google Scholar, China National Knowledge Infrastructure, CQVIP, Wanfang 
   Data, and SINOMED Databases for randomized controlled trials (RCTs) of 
   acupuncture and moxibustion therapy for BCRL from inception to March 30, 2023. 
   The quality of the included literature was assessed using the Cochrane risk of 
   bias assessment, and data were analyzed and plotted using R4.3.2 and Stata 15.1 
   software. RESULTS: We included 27 RCTs including 8 acupuncture interventions with 
   a sample size of 1976 cases. The results of the network meta-analysis showed that 
   acupuncture + moxibustion, moxibustion, blood-letting puncture and cupping, and 
   electroacupuncture combined with conventional rehabilitation were superior to 
   conventional rehabilitation alone in reducing arm circumference. Moxibustion 
   combined with conventional rehabilitation was superior to conventional 
   rehabilitation alone in reducing the degree of edema. Electroacupuncture and 
   acupoint massage combined with conventional rehabilitation were superior to 
   conventional rehabilitation alone in reducing the visual analogue scale (VAS) 
   scores. And in terms of improving the mobility of the shoulder joint, moxibustion 
   and electroacupuncture combined with conventional rehabilitation were better than 
   conventional rehabilitation alone. CONCLUSION: The combination of acupuncture and 
   moxibustion therapy with conventional rehabilitation can improve the efficacy of 
   BCRL. Acupuncture + moxibustion was the best treatment modality to reduce arm 
   circumference, acupuncture was the best modality to reduce edema, and 
   electroacupuncture was the most effective modality for relieving BCRL pain 
   symptoms and was the best choice to improve abduction range of motion (ROM). Due 
   to the limitations of this study, this conclusion remains to be validated by 
   further high-quality clinical studies.
C1 Beijing University of Chinese Medicine, Beijing, China.
   Tumor Center, Beijing Anorectal Hospital, Beijing, China.
   Beijing University of Chinese Medicine, Beijing, China.
   Beijing University of Chinese Medicine, Beijing, China.
   Beijing University of Chinese Medicine, Beijing, China. lcz623780@126.com.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD SEP 13
PY 2025
VL 33
IS 10
BP 850
EP 850
DI 10.1007/s00520-025-09861-4 
PG 0
WC Female; Humans; Acupuncture Therapy; methods; Bayes Theorem; Breast Cancer Lymphedema; therapy; Breast Neoplasms; complications; Moxibustion; methods; Randomized Controlled Trials as Topic
UT PubMed:40944772
PM 40944772
DA 2025-09-13
ER

PT J
AU Hopkins, Hollis AS
AF Hopkins Hollis, Anne Seton
TI Acupuncture as a treatment modality for the management of cancer pain: the state 
SO Oncology nursing forum
LA English
DT Review
AB PURPOSE/OBJECTIVES: To explore the current state of the science regarding 
   acupuncture as a treatment modality for cancer pain. DATA SOURCES: PubMed and 
   CINAHL databases were searched, as were Web sites from the National Cancer 
   Institute, the National Institute of Health's Complementary and Alternative 
   Medicine Program, and the American Cancer Society. DATA SYNTHESIS: This article 
   synthesizes nine years of published research on the use of acupuncture as an 
   adjunct treatment for the management of cancer pain. CONCLUSIONS: Findings 
   suggest a lack of level I evidence regarding the use of acupuncture as a cancer 
   pain treatment modality. The majority of evidence is level III or higher; 
   therefore, causality cannot be inferred. IMPLICATIONS FOR NURSING: Future 
   research should focus on level I and level II evidence, controlling for variables 
   to strengthen validity, and addressing sample size to enhance the 
   generalizability of results. Nurses should be knowledgeable about the state of 
   the science evidence available to assist patients in making educated decisions.
C1 School of Nursing, Johns Hopkins University, Baltimore, MD, USA. ahopkin9@son.jhmi.edu
NR 0
TC 0
SN 1538-068
EI 
J9 Oncol Nurs Forum
PD AUG 28
PY 2010
VL 37
IS 5
BP E344
EP 8
DI 10.1188/10.ONF.E344-E348 
PG 1
WC Acupuncture Therapy; nursing; Humans; Neoplasms; nursing; Pain; nursing; Pain Management; Randomized Controlled Trials as Topic
UT PubMed:20797942
PM 20797942
DA 2010-08-28
ER

PT J
AU Enblom, A
AF Enblom, Anna
TI Patients' and physiotherapists' belief in and use of acupuncture for 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE ACUPUNCTURE; COMPLEMENTARY MEDICINE; ONCOLOGY; PAIN MANAGEMENT; PHYSIOTHERAPY; REHABILITATION MEDICINE
AB BACKGROUND: It is important to investigate attitudes to acupuncture, because 
   therapists' and patients' expectations may affect the treatment outcome. AIM: To 
   explore the use of and belief in acupuncture among oncological physiotherapists 
   and to explore patients' interest in receiving acupuncture during cancer therapy 
   and their belief in its effectiveness. METHODS: 522 patients (80% female, mean 
   age 67 years) reported on their interest in receiving acupuncture for nausea 
   during radiotherapy treatment; a subgroup (n=198) additionally disclosed their 
   belief in the effectiveness of acupuncture. 117 Swedish oncological 
   physiotherapists (96% female, mean age 48 years) answered a questionnaire 
   regarding their use of and belief in acupuncture. RESULTS: Of the patients 
   initiating cancer therapy, 359 (69%) were interested in receiving acupuncture. 
   The patients believed acupuncture to be effective for pain (79%), nausea (79%) 
   and vasomotor symptoms (48%). Of the 117 physiotherapists, 66 (56%) practised 
   acupuncture. Physiotherapists generally believed in the effectiveness of 
   acupuncture. For pain, 89% believed that acupuncture was effective and 42% of 
   them practised it. Similar responses were noted for chemotherapy-induced nausea 
   (86% and 38%, respectively) and vasomotor symptoms (80% and 28%, respectively). 
   Younger physiotherapists and patients were more likely to believe in the 
   effectiveness of acupuncture compared with older ones. CONCLUSIONS: More than two 
   thirds of patients with cancer were interested in receiving acupuncture during 
   therapy. Patients and oncological physiotherapists believed that acupuncture was 
   effective for cancer pain, nausea and vasomotor symptoms. Further studies of 
   acupuncture for cancer-related symptoms and of the effect of patients' and 
   clinicians' therapeutic relationships, including treatment expectations, would be 
   welcome.
C1 Department of Medical and Health Sciences, Division of Physiotherapy, Linköping University, Linköping, Sweden.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD APR 27
PY 2017
VL 35
IS 4
BP 251
EP 258
DI 10.1136/acupmed-2015-011007 
PG 7
WC Acupuncture Therapy; psychology; Adult; Aged; Antineoplastic Agents; adverse effects; Cancer Pain; etiology; Cross-Sectional Studies; Culture; Drug Therapy; Female; Humans; Male; Middle Aged; Nausea; etiology; Neoplasms; drug therapy; Oncologists; psychology; Patients; psychology; Radiotherapy; adverse effects; Surveys and Questionnaires; Treatment Outcome
UT PubMed:28442462
PM 28442462
DA 2017-04-27
ER

PT J
AU Yang, M
   Baser, RE
   Khanin, R
   Autuori, I
   Li, QS
   Panageas, KS
   Orlow, I
   Mao, JJ
AF Yang, Mingxiao
   Baser, Raymond E
   Khanin, Raya
   Autuori, Isidora
   Li, Qing S
   Panageas, Katherine S
   Orlow, Irene
   Mao, Jun J
TI COMT Val158Met Affects the Analgesic Response to Acupuncture Among Cancer 
SO The journal of pain
LA English
DT Journal Article
DE COMT Val158Met; acupuncture; cancer survivors; chronic pain; treatment response
AB Catechol-O-methyltransferase (COMT) is the major enzyme involved in the 
   catabolism of dopamine, a neurotransmitter in the brain's reward system. The 
   common COMT polymorphism Val158Met (rs4680 G>A) modulates pain response to 
   opioids through a reward-motivated mechanism; however, its role in 
   nonpharmacological pain medicine has not been clinically characterized. We 
   genotyped 325 participants from a randomized controlled trial of cancer survivors 
   with chronic musculoskeletal pain. We found that carrying methionine at position 
   158 (158Met) of COMT, encoded by the A allele, significantly increased the 
   analgesic response to electroacupuncture (74% vs 50%; odds ratio [OR]: 2.79; 95% 
   confidence interval [CI]: 1.31, 6.05; P < .01), but not to auricular acupuncture 
   (68% vs 60%; OR: 1.43; 95% CI: .65, 3.12; P = .37) or usual care (24% vs 18%; OR: 
   1.46; 95% CI: .38, 7.24; P = .61) compared to Val/Val. These findings raise the 
   possibility that COMT Val158Met might be an important predictor of analgesic 
   response to electroacupuncture, providing novel insights into precision 
   nonpharmacologic pain management tailored to individual genetic backgrounds. 
   PERSPECTIVE: This work suggests the modulating effects of the polymorphism in 
   COMT Val158Met on the response to acupuncture. Further research needs to validate 
   these findings, increase the mechanistic understanding of acupuncture, and guide 
   further development of acupuncture as a precision pain management strategy.
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
   Bioinformatics Core Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. 
EM maoj@mskcc.org
NR 0
TC 0
SN 1528-844
EI 1526-590
J9 J Pain
PD MAY 16
PY 2023
VL 24
IS 9
BP 1721
EP 1730
DI 10.1016/j.jpain.2023.05.005 
PG 9
WC Humans; Catechol O-Methyltransferase; genetics; Chronic Pain; genetics; Cancer Survivors; Genotype; Acupuncture Therapy; Analgesics, Opioid; Polymorphism, Single Nucleotide; genetics; Neoplasms
UT PubMed:37187218
PM 37187218
DA 2023-05-16
ER

PT J
AU Zhang, S
   Li, Y
   Liang, Z
   Dai, J
   Huang, H
   Zhang, H
   Yang, B
   Wang, J
   Tang, D
AF Zhang, Shaowang
   Li, Yuanyin
   Liang, Zhide
   Dai, Jiaxing
   Huang, Hong
   Zhang, Huanghui
   Yang, Bing
   Wang, Jinghui
   Tang, Dongxin
TI Comparing the effects of different non-pharmacological traditional Chinese 
SO Complementary therapies in medicine
LA English
DT Review
DE Cancer survivors; Fatigue; Network Meta-Analysis; Non-pharmacological traditional Chinese medicine therapies; Pain
AB OBJECTIVES: Several studies have demonstrated the positive impact of 
   non-pharmacological Traditional Chinese Medicine (TCM) therapies on pain, 
   fatigue, sleep quality, and quality of life in cancer survivors. However, no 
   research has compared the effectiveness of these therapies. This study aims to 
   compare various interventions and identify the most effective non-pharmacological 
   TCM therapies to provide evidence-based recommendations for cancer survivors. 
   METHODS: A systematic search was conducted in PubMed, Embase, Web of Science, 
   CNKI, and Wanfang Data. RCTs investigating the effects of Taichi, Qigong, 
   acupuncture, acupressure, TCM emotional therapy, and mixed therapies as 
   interventions for cancer survivors were screened was conducted. Data from the 
   creation of the database to February 2025 were included. Two independent 
   reviewers evaluated the study quality. A Bayesian Network Meta-analysis was 
   conducted to carry out a random effects model. RESULTS: Seventy-one RCTs 
   involving 6473 patients were included in the analysis. Network meta-analysis 
   showed significance for all five intervention therapies in pain control in cancer 
   patients. The best efficacy was observed for acupressure (SMD=-1.1 [-1.55, 
   -0.66]) and Taichi/Qigong (SMD=-1.08[-1.64, -0.53]), followed by TCM emotional 
   therapy (SMD=-0.93 [-1.42, -0.44]) and acupuncture (SMD=-0.54 [-0.93, -0.15]), 
   with the latter showing comparatively lower efficacy. None of the interventions 
   demonstrated superior efficacy in improving fatigue compared to the control 
   group. Mixed therapies (SMD=-1.36[-2.56, -0.28]) demonstrated the greatest effect 
   in improving sleep quality. Taichi/Qigong (SMD=1.87 [0.96, 2.83]) demonstrated 
   certain advantages in improving quality of life. However, acupuncture and TCM 
   emotional therapy had no significant effect on sleep quality or overall quality 
   of life. CONCLUSION: The evidence from this study suggests that acupressure and 
   Taichi/Qigong are recommended as the most effective therapies for pain relief and 
   quality of life improvement, respectively. The efficacy of these therapies for 
   fatigue remains inconclusive. However, due to the limited number of included 
   studies and the high risk of bias, these results should be interpreted with 
   caution. Future studies should include more rigorously designed high-quality 
   randomized controlled trials to confirm their long-term efficacy and safety. 
   REGISTRATION: PROSPERO CRD42024601976.
C1 Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
   Talent Base for TCM Tumor Inheritance and Science and Technology Innovation of GuizhouProvince, Guiyang 550000, China. 
   Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
   Talent Base for TCM Tumor Inheritance and Science and Technology Innovation of GuizhouProvince, Guiyang 550000, China. 
   Department of Physical Education, College of Physical Education, Qingdao University, Qingdao 266071, China. 
   Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
   Talent Base for TCM Tumor Inheritance and Science and Technology Innovation of GuizhouProvince, Guiyang 550000, China. 
   Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
   Talent Base for TCM Tumor Inheritance and Science and Technology Innovation of GuizhouProvince, Guiyang 550000, China. 
   Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
   Talent Base for TCM Tumor Inheritance and Science and Technology Innovation of GuizhouProvince, Guiyang 550000, China. 
   Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
   The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550000, China
   Talent Base for TCM Tumor Inheritance and Science andTechnology Innovation of Guizhou Province, Guiyang 550000, China. Electronicaddress: 1006019442@qq.com.
   Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
   The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550000, China
   Talent Base for TCM Tumor Inheritance and Science andTechnology Innovation of Guizhou Province, Guiyang 550000, China. Electronicaddress: 547917662@qq.com.
   Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
   The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550000, China
   Talent Base for TCM Tumor Inheritance and Science andTechnology Innovation of Guizhou Province, Guiyang 550000, China. Electronicaddress: hemingankang@sina.com.
EM 1257379762@qq.com
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD MAR 30
PY 2025
VL 90
IS 
BP 103164
EP 103164
DI 10.1016/j.ctim.2025.103164 
PG 0
WC Humans; Acupressure; Acupuncture Therapy; Bayes Theorem; Cancer Survivors; Fatigue; therapy; Medicine, Chinese Traditional; methods; Neoplasms; therapy; Qigong; Quality of Life; Randomized Controlled Trials as Topic
UT PubMed:40157553
PM 40157553
DA 2025-03-30
ER

PT J
AU Oh, B
   Eade, T
   Kneebone, A
   Pavlakis, N
   Clarke, S
   Eslick, G
   River, J
   Back, M
AF Oh, Byeongsang
   Eade, Thomas
   Kneebone, Andrew
   Pavlakis, Nick
   Clarke, Stephen
   Eslick, Guy
   River, Jo
   Back, Michael
TI Factors affecting whether or not cancer patients consider using acupuncture.
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE ACUPUNCTURE; ONCOLOGY
AB OBJECTIVE: To explore the factors associated with utilisation of an acupuncture 
   service in a tertiary oncology setting in an Australian public hospital. METHOD: 
   Cancer patients attending oncology clinics at a university teaching hospital were 
   invited to participate in the evaluation of acupuncture services from June 2014 
   to May 2015. Patients had a prior diagnosis of cancer (albeit at different 
   stages) and were planning to receive, or were already receiving, systemic and/or 
   radiation cancer treatment. RESULTS: The majority (81%) of participants indicated 
   that they would consider the use of acupuncture during their cancer treatment. 
   The most common reasons given for not considering acupuncture included adequate 
   control of symptoms already with medical treatment, inconvenient clinic timing, 
   and needle phobia. The main reasons given for considering acupuncture use 
   included its perceived capability of reducing fatigue, boosting energy levels, 
   improving immune function, and reducing pain and anxiety. Patients considering 
   acupuncture use also demonstrated significantly higher levels of stress 
   (p<0.001), anxiety and depression (p<0.001), fatigue (p<0.001), and lower global 
   quality of life (p<0.01) compared to those who were not considering acupuncture. 
   CONCLUSIONS: The findings show that demand for acupuncture by cancer patients is 
   high. A substantial proportion of cancer patients intend to use acupuncture to 
   manage cancer and/or cancer treatment-related symptoms. Discussion with patients 
   about acupuncture and other complementary therapies during the consultation may 
   improve cancer care.
C1 Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.
   Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
   Harvard Medical School, Boston, Massachusetts, USA.
   Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.
   Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
   Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.
   Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
   Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.
   Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
   Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.
   Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
   Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
   Sydney Nursing School, University of Sydney, Camperdown, New South Wales, Australia.
   Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.
   Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD SEP 24
PY 2016
VL 35
IS 2
BP 107
EP 113
DI 10.1136/acupmed-2016-011115 
PG 6
WC Acupuncture Therapy; Adolescent; Adult; Aged; Anxiety; etiology; Australia; Cross-Sectional Studies; Fatigue; etiology; Female; Humans; Male; Middle Aged; Neoplasms; complications; Pain; etiology; Pain Management; Quality of Life; Young Adult
UT PubMed:27658799
PM 27658799
DA 2016-09-24
ER

PT J
AU Shi, Y
   Nguyen, T
   Farrell, M
   Rodgers-Melnick, S
   Moss, G
   Kaiser, C
   Dusek, JA
   Mendiratta, P
   Adan, F
   Lee, RT
AF Shi, Yuming
   Nguyen, Thuy
   Farrell, Megan
   Rodgers-Melnick, Samuel
   Moss, Gabriel
   Kaiser, Christine
   Dusek, Jeffery A
   Mendiratta, Prateek
   Adan, Francoise
   Lee, Richard T
TI Retrospective Outcomes of a New Acupuncture Service at a Comprehensive Cancer 
SO Journal of integrative and complementary medicine
LA English
DT Journal Article
DE acupuncture; cancer; integrative oncology; symptom management
AB Introduction: Among cancer centers, patients' interest in acupuncture is growing, 
   in addition to clinical research in the intervention. Their National Cancer 
   Institute-designated comprehensive cancer center piloted an acupuncture service. 
   Their aim was to assess whether acupuncture impacted patient self-reported 
   symptoms as delivered clinically and discuss their implementation strategy. 
   Methods: Patients undergoing acupuncture at a comprehensive cancer center from 
   June 2019 to March 2020 were asked to complete a modified Edmonton Symptom 
   Assessment Scale (ESAS) before and after each session. The authors evaluated 
   symptom changes after acupuncture in both outpatient and inpatient settings. A 
   change of ≥1 U, on the 0-10 scale, was considered clinically significant. 
   Results: Three hundred and nine outpatient and 394 inpatient acupuncture sessions 
   were provided to patients at the comprehensive cancer center during this period, 
   of which surveys from 186 outpatient (34 patients) and 124 inpatient (57 
   patients) sessions were available for analysis. The highest pretreatment symptoms 
   reported by outpatients were neuropathy (5.78), pain (5.58), and tiredness 
   (5.59). Outpatients receiving acupuncture reported clinically significant 
   improvements in pain (ESAS score change of -2.97), neuropathy (-2.68), decreased 
   lack of well-being (-2.60), tiredness (-1.85), nausea (-1.83), anxiety (-1.56), 
   activities of daily living issues (-1.32), depression (-1.23), anorexia (-1.19), 
   insomnia (-1.14), and shortness of breath (-1.14). The most severe pretreatment 
   symptoms reported by inpatients were pain (6.90), insomnia (6.16), and 
   constipation (5.44). Inpatients receiving acupuncture reported clinically 
   significant improvements in anxiety (-3.69), nausea (-3.61), insomnia (-3.26), 
   depression (-2.98), pain (-2.77), neuropathy (-2.68), anorexia (-2.20), 
   constipation (-1.95), and diarrhea (-1.26). Conclusion: Both outpatient and 
   inpatient participants in this pilot acupuncture program reported clinically 
   significant improvements in symptoms after a single acupuncture treatment. Some 
   differences between the outpatient and inpatient settings warrant further 
   investigation.
C1 Case Western Reserve University, Cleveland, OH, USA.
   University Hospitals Connor Whole Health, Cleveland, OH, USA.
   Cleveland Clinic, Cleveland, OH, USA.
   Case Western Reserve University, Cleveland, OH, USA.
   Case Western Reserve University, Cleveland, OH, USA.
   University Hospitals Connor Whole Health, Cleveland, OH, USA.
   Case Western Reserve University, Cleveland, OH, USA.
   University Hospitals Connor Whole Health, Cleveland, OH, USA.
   Case Western Reserve University, Cleveland, OH, USA.
   University Hospitals Connor Whole Health, Cleveland, OH, USA.
   Case Western Reserve University, Cleveland, OH, USA.
   University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
   Case Western Reserve University, Cleveland, OH, USA.
   University Hospitals Connor Whole Health, Cleveland, OH, USA.
   Case Western Reserve University, Cleveland, OH, USA.
   University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
   Integrative Medicine Program, Departments of Supportive Care Medicine and Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
NR 0
TC 0
SN 2768-361
EI 
J9 J Integr Complement Med
PD MAY 30
PY 2023
VL 29
IS 10
BP 674
EP 682
DI 10.1089/jicm.2022.0709 
PG 8
WC Humans; Sleep Initiation and Maintenance Disorders; Retrospective Studies; Activities of Daily Living; Anorexia; Pain; Acupuncture Therapy; Constipation; therapy; Nausea; etiology; Neoplasms; complications
UT PubMed:37252748
PM 37252748
DA 2023-05-30
ER

PT J
AU Serçe, S
   Ovayolu, Ö
   Pirbudak, L
   Ovayolu, N
AF Serçe, Sibel
   Ovayolu, Özlem
   Pirbudak, Lütfiye
   Ovayolu, Nimet
TI The Effect of Acupressure on Pain in Cancer Patients With Bone Metastasis: A 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupressure; cancer; metastasis; nursing; pain; radiotherapy
AB BACKGROUND: Pain is a serious and common problem in bone metastases. For this 
   purpose, complementary and supportive practices are also applied along with 
   medical treatment. This study was conducted for the purpose of evaluating the 
   effect of acupressure on pain in cancer patients with bone metastasis. METHODS: 
   The study was conducted in a nonrandomized controlled trial with patients who 
   applied to the radiotherapy unit of an oncology hospital. The data of the study 
   were collected by using a questionnaire and the Visual Analog Scale. A total of 8 
   acupressure sessions, which lasted for approximately 10 minutes each (with 
   warming and acupressure periods), was applied to the intervention group. The data 
   were analyzed by using χ(2) test, paired t test, and Pearson's correlation 
   coefficient. RESULTS: It was determined that the pain mean score of the 
   intervention group was 7.6 ± 1.9 before the acupressure and decreased to 6.8 ± 
   1.9 after the acupressure and this result was statistically significant. On the 
   other hand, no significant difference was determined in the pain mean score of 
   the control group. CONCLUSIONS: Acupressure is applicable for cancer patients 
   with bone metastasis by nursing staff after receiving brief training and may make 
   a difference in relieving pain of the patients. Further well-designed trials 
   should be conducted.
C1 1 Gaziantep University Hospital.
   2 Department of Nursing, Faculty of Health Science, Gaziantep University.
   3 School of Medicine, Gaziantep University.
   4 Department of Nursing, Faculty of Health Science, Gaziantep University.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD APR 14
PY 2018
VL 17
IS 3
BP 728
EP 736
DI 10.1177/1534735418769153 
PG 8
WC Acupressure; methods; Adult; Bone Neoplasms; complications; Cancer Pain; etiology; Female; Humans; Male; Middle Aged; Pain Management; methods; Surveys and Questionnaires; Visual Analog Scale; Young Adult
UT PubMed:29649905
PM 29649905
DA 2018-04-14
ER

PT J
AU Wang, J
   Lei, Y
   Bao, B
   Yu, X
   Dai, H
   Chen, F
   Li, H
   Wang, B
AF Wang, Jisheng
   Lei, Yi
   Bao, Binghao
   Yu, Xudong
   Dai, Hengheng
   Chen, Fei
   Li, Haisong
   Wang, Bin
TI Acupuncture for pain caused by prostate cancer: Protocol for a systematic review.
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Prostate cancer is a male malignant tumor disease with high 
   prevalence in recent years. Patients with advanced prostate cancer are more 
   likely to have bone metastasis and strong bone pain, and even lead to 
   pathological fracture, which has a serious impact on the quality of life of 
   patients. Acupuncture has good clinical efficacy in treating pain caused by 
   prostate cancer. This review hopes to adopt meta-analysis to evaluate the 
   efficacy and safety of acupuncture in the treatment of pain caused by prostate 
   cancer and provides evidence for its application in clinical practice. METHODS 
   AND ANALYSIS: We will search for PubMed, Cochrane Library, AMED, EMbase, 
   WorldSciNet, Nature, Science online and China Journal Full-text Database (CNKI), 
   China Biomedical Literature CD-ROM Database (CBM), and related randomized 
   controlled trials included in the China Resources Database. The time is limited 
   from the construction of the library to November 2018. We will use the criteria 
   provided by Cochrane 5.1.0 for quality assessment and risk assessment of the 
   included studies, and use the Revman 5.3 and Stata 13.0 software for 
   meta-analysis of the effectiveness, recurrence rate, and symptom scores of 
   epididymitis. ETHICS AND DISSEMINATION: This systematic review will evaluate the 
   efficacy and safety of acupuncture for pain caused by prostate cancer. Owing to 
   the fact that all of the data used in this systematic review and meta-analysis 
   have been published, this review does not require ethical approval. Furthermore, 
   all data will be anonymously analyzed during the review process trial. TRIAL 
   REGISTRATION NUMBER: PROSPERO CRD42018111550.
C1 Graduate School of Beijing University of Chinese Medicine.
   Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese 
   Department of Andrology, The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Shaanxi, China.
   Graduate School of Beijing University of Chinese Medicine.
   Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese 
   Graduate School of Beijing University of Chinese Medicine.
   Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese 
   Graduate School of Beijing University of Chinese Medicine.
   Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese 
   Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing.
   Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing.
   Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JAN 12
PY 2019
VL 98
IS 2
BP e13954
EP e13954
DI 10.1097/MD.0000000000013954 
PG 1
WC Acupuncture Therapy; methods; Bone Neoplasms; complications; Cancer Pain; therapy; Humans; Male; Prostatic Neoplasms; complications; Quality of Life; Randomized Controlled Trials as Topic; Research Design; Meta-Analysis as Topic; Systematic Reviews as Topic
UT PubMed:30633174
PM 30633174
DA 2019-01-12
ER

PT J
AU Sharifi, Rizi M
   Shamsalinia, A
   Ghaffari, F
   Keyhanian, S
   Naderi, Nabi B
AF Sharifi Rizi, Moloud
   Shamsalinia, Abbas
   Ghaffari, Fatemeh
   Keyhanian, Shahrbanoo
   Naderi Nabi, Bahram
TI The effect of acupressure on pain, anxiety, and the physiological indexes of 
SO Complementary therapies in clinical practice
LA English
DT Journal Article
DE Acupressure; Anxiety; Aspiration; Biopsy; Bone marrow; Pain; Physiological indexes
AB OBJECTIVES: This study aimed to determine the effect of acupressure on pain 
   intensity, anxiety, and physiological indexes of patients with cancer undergoing 
   bone marrow biopsy and aspiration. METHODS: The study was designed as a 
   randomized, double-blinded, controlled trial. Ninety samples was selected using 
   the convenience sampling method, then for allocation groups random block sampling 
   was used (30 for each group). The three groups were similar by age and gender. 
   LI4 and HT7 (Shen Men) acupressure points were examined for the intervention. 
   Sham pressure was used in the placebo group while no intervention was applied in 
   the control group. RESULTS: The results showed that the lowest average anxiety 
   score (1.5 ± 0.5; P = 0.01) and the lowest average pain score (4.9 ± 0.8) after 
   the intervention were related to the acupressure method (P = 0.001). CONCLUSION: 
   Cost effectiveness and short-term simple education make acupressure method useful 
   in clinical settings for different illnesses.
C1 Ramsar Nursing Care Research Center, Babol University of Medical Sciences, Babol, Mazandaran, Iran. 
   Ramsar Nursing Care Research Center, Babol University of Medical Sciences, Babol, Mazandaran, Iran. 
   Ramsar Nursing Care Research Center, Babol University of Medical Sciences, Babol, Mazandaran, Iran. 
   Department of Oncology, Azad University of Tonekabon, Tonekabon, Mazandaran, Iran. 
   Anesthesiology Department, Anesthesiology Research Center, Guilan University of Medical Sciences, Rasht, Iran. 
EM naderi_bahram@gums.ac.ir
NR 0
TC 0
SN 1873-694
EI 
J9 Complement Ther Clin Pract
PD NOV 11
PY 2017
VL 29
IS 
BP 136
EP 141
DI 10.1016/j.ctcp.2017.09.002 
PG 5
WC Acupressure; methods; Adult; Aged; Anxiety; prevention & control; Biopsy, Needle; Bone Marrow; Female; Humans; Male; Middle Aged; Neoplasms; pathology; Pain; prevention & control; Pain Management; methods
UT PubMed:29122251
PM 29122251
DA 2017-11-11
ER

PT J
AU He, Y
   May, BH
   Zhang, AL
   Guo, X
   Liu, Y
   Qu, Y
   Chang, X
   Lu, CJ
   Xue, CC
   Zhang, H
AF He, Yihan
   May, Brian H
   Zhang, Anthony Lin
   Guo, Xinfeng
   Liu, Yihong
   Qu, Yanchun
   Chang, Xuesong
   Lu, Chuan-Jian
   Xue, Charlie Changli
   Zhang, Haibo
TI Acupuncture for cancer pain: protocol for a pilot pragmatic randomised controlled 
SO BMJ open
LA English
DT Journal Article
DE acupuncture; cancer pain; pilot; pragmatic randomised controlled trial; protocol
AB INTRODUCTION: Although acupuncture has been recommended for alleviating cancer 
   pain by clinical guidelines, the level of the supporting evidence needs to be 
   improved. A pragmatic randomised controlled trial (pRCT) in a hospital setting 
   would provide real-world assessments of the overall clinical effects of 
   acupuncture. This pilot trial aims to explore the feasibility and provide data 
   for sample size calculations for a pRCT evaluating the effectiveness of 
   acupuncture as an adjunctive therapy to routine medical care for cancer pain. 
   METHODS AND ANALYSIS: Thirty patients with cancer admitted to the oncology 
   department with moderate or severe pain will be recruited. Participants will be 
   randomised at a ratio of 1:1 to the adjunctive acupuncture group or a control 
   group which receives routine pain management without acupuncture. The 
   standardised section of the acupuncture protocol will be developed based on the 
   results of reviews of the literature, recommendations in clinical guidelines and 
   interviews with clinical experts. The acupuncturist will be allowed to tailor the 
   protocol according to the individual situation of each participant. Primary 
   outcomes relevant to the feasibility of conducting a fully powered trial include: 
   numbers and proportions of participants recruited, screened, consented and 
   randomised; numbers and reasons for withdrawals and dropouts; numbers and types 
   of adverse events; feasibility of implementing the trial procedures; evaluation 
   of the comprehensiveness and ease-of-use of the case report form. Secondary 
   outcomes are clinical measurements of the effectiveness of the treatment that are 
   intended for use in the full-scale trial. Analysis of feasibility will be 
   descriptive and pain intensity measures will be analysed using mixed-effects 
   regression. ETHICS AND DISSEMINATION: Ethics approval was obtained from the 
   Institutional Ethics Committee of Guangdong Provincial Hospital of Chinese 
   Medicine (approval no: Z2017-184-01) and RMIT University Human Research Ethics 
   Committee (reference no: 21361). Results will be disseminated in a peer-reviewed 
   journal, and trial participants will be informed via email and/or phone calls. 
   TRIAL REGISTRATION NUMBER: ChiCTR1800017023.
C1 Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangdong Provincial Academy ofChinese Medical Science, Guangzhou, Guangdong, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
   China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
   Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangdong Provincial Academy ofChinese Medical Science, Guangzhou, Guangdong, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangdong Provincial Academy ofChinese Medical Science, Guangzhou, Guangdong, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangdong Provincial Academy ofChinese Medical Science, Guangzhou, Guangdong, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangdong Provincial Academy ofChinese Medical Science, Guangzhou, Guangdong, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangdong Provincial Academy ofChinese Medical Science, Guangzhou, Guangdong, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangdong Provincial Academy ofChinese Medical Science, Guangzhou, Guangdong, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD JUL 11
PY 2019
VL 9
IS 7
BP e025564
EP e025564
DI 10.1136/bmjopen-2018-025564 
PG 1
WC Acupuncture Therapy; Adult; Cancer Pain; psychology; Female; Humans; Male; Pain Management; methods; Pain Measurement; Pilot Projects; Pragmatic Clinical Trials as Topic; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:31289059
PM 31289059
DA 2019-07-11
ER

PT J
AU Dai, L
   Liu, Y
   Ji, G
   Xu, Y
AF Dai, Liang
   Liu, Yang
   Ji, Guang
   Xu, Yangxian
TI Acupuncture and Derived Therapies for Pain in Palliative Cancer Management: 
SO Journal of palliative medicine
LA English
DT Journal Article
DE acupuncture; cancer pain; systematic review
AB Background: Acupuncture is a classical complementary therapy, but benefits in 
   palliative cancer pain are still unclear due to lack of consistent evidence. 
   Objectives: To comprehensively evaluate the effectiveness of acupuncture and 
   derived therapies (such as electroacupuncture, laser acupuncture, and 
   transcutaneous electrical nerve stimulation) for analgesia in palliative cancer 
   care based on both single-arm and controlled trials. Design: Eight databases were 
   searched from inception to August 31, 2020. Both single-arm trials and controlled 
   trials were included. The primary outcome was the change in pain intensity, as 
   evaluated by the numeric rating scale (NRS) and the visual analog scale. 
   Subjects: Adults with cancer. Results: Forty-one controlled studies with 2685 
   participants and 18 single-arm studies with 1084 participants were included. For 
   controlled trials, meta-analysis indicated that acupuncture and derived therapies 
   in addition led to greater reductions in the NRS score than conventional 
   analgesics alone (weighted mean difference [WMD]: 1.33 [0.85-1.82], p < 0.001). 
   For single-arm trials, meta-analysis showed that both the immediate effect (WMD: 
   1.57 [1.43-1.71], p < 0.001) and long-term longitudinal effect (WMD: 1.81 
   [1.25-2.37], p < 0.001) of acupuncture on analgesia were positive, as evaluated 
   by the NRS, respectively. The benefits of acupuncture and derived therapies were 
   also seen in quality of life and the global improvement rate. LI4 (Hegu) was the 
   most frequently used acupoint. Conclusions: This systematic review supported the 
   application of acupuncture and derived therapies for managing pain during 
   palliative cancer care from two dimensions. Further studies could explore the 
   effect of acupuncture on other predominant symptoms in palliative cancer 
   patients.
C1 Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Department of Gastrointestinal Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Department of Gastrointestinal Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
NR 0
TC 0
SN 1557-774
EI 
J9 J Palliat Med
PD MAR 12
PY 2021
VL 24
IS 7
BP 1078
EP 1099
DI 10.1089/jpm.2020.0405 
PG 21
WC Acupuncture Therapy; Adult; Complementary Therapies; Humans; Neoplasms; complications; Pain; Palliative Care; Quality of Life; Randomized Controlled Trials as Topic
UT PubMed:33691493
PM 33691493
DA 2021-03-12
ER

PT J
AU Paley, CA
   Johnson, MI
   Bennett, MI
AF Paley, Carole A
   Johnson, Mark I
   Bennett, Michael I
TI Should physiotherapists use acupuncture for treating patients with cancer-induced 
SO Physiotherapy
LA English
DT Review
AB BACKGROUND: Patients suffering from pain due to bony metastases in cancer 
   represent a challenge to the physiotherapist as part of the multidisciplinary 
   team. Adequate pain relief improves quality of life and functional status, yet 
   conventional analgesia often has undesirable side-effects and non-pharmacological 
   treatments (e.g. some electrotherapies) may be contraindicated in cancer. 
   Acupuncture is a potential treatment for cancer-induced bone pain (CIBP) as it 
   has few side effects and is relatively easy to administer. There is a dearth of 
   research on the use of acupuncture in treating CIBP and some practitioners 
   express fears about treating cancer patients with acupuncture. OBJECTIVES: To 
   discuss the use of acupuncture for CIBP by reviewing the physiological rationale 
   for using acupuncture to treat CIBP and the risks and benefits of using 
   acupuncture in clinical practice. DATA SOURCES: Evidence was identified by 
   searching seven major databases: Cochrane Central Register of Controlled Trials 
   (CENTRAL), MEDLINE, EMBASE, CINAHL, PsycINFO, AMED and SPORTDiscus. Evidence was 
   synthesised by the authors to raise issues and discussion points within a 
   narrative review framework. FINDINGS: Available physiological evidence supports 
   potentially efficacious effects of acupuncture for reduction of CIBP. Clinical 
   literature suggests that acupuncture may be effective as an adjunctive treatment 
   for CIBP and that risks are manageable. However, there is a need for 
   well-designed randomised controlled trials to investigate efficacy and 
   effectiveness in patients. CONCLUSIONS: Acupuncture has the potential to provide 
   sustained background analgesia and/or rapid onset analgesia for breakthrough pain 
   if the appropriate points and techniques are used.
C1 Airedale NHS Foundation Trust, Steeton, Keighley BD206TD, UK. biodynamics.physiotherapy@tesco.net
NR 0
TC 0
SN 1873-146
EI 
J9 Physiotherapy
PD AUG 9
PY 2011
VL 97
IS 3
BP 256
EP 63
DI 10.1016/j.physio.2010.08.008 
PG -193
WC Acupuncture Analgesia; standards; Bone and Bones; Evidence-Based Practice; Humans; Neoplasms; complications; Pain; physiopathology; Physical Therapy Modalities; standards; Risk Assessment
UT PubMed:21820545
PM 21820545
DA 2011-08-09
ER

PT J
AU Dong, B
   Lin, L
   Chen, Q
   Qi, Y
   Wang, F
   Qian, K
   Tian, L
AF Dong, Bei
   Lin, Lu
   Chen, Qiuyun
   Qi, Yishu
   Wang, Fen
   Qian, Keyan
   Tian, Li
TI Wrist-ankle acupuncture has a positive effect on cancer pain: a meta-analysis.
SO BMC complementary medicine and therapies
LA English
DT Journal Article
DE Cancer; Meta-analysis; Pain; Randomized controlled trial; Wrist-ankle acupuncture
AB BACKGROUND: Wrist-ankle acupuncture (WAA) as a kind of micro acupuncture therapy 
   has been used to management cancer pain, however, the effects of WAA on cancer 
   pain were controversial in the current studies. Therefore, the purpose of this 
   meta-analysis was to critically evaluate the effect of wrist-ankle acupuncture 
   (WAA) on cancer pain. METHODS: Seven digital databases were searched from the 
   inception of databases to July 2020, including CNKI, Wanfang, VIP, CBM, Cochrane 
   Library, PubMed and Embase. Randomized controlled trials conforming to the 
   inclusion and exclusion criteria were screened and extracted; the risk of bias 
   was evaluated using the Cochrane Collaboration criteria. The primary outcome 
   indicators included pain relief rate and pain score, and the secondary outcome 
   was adverse reaction incidence. All analyses were performed with Review Manager 
   5.3. RESULTS: A total of 13 studies with 1005 cancer patients (intervention 
   group: 568, control group: 437) were included in this meta-analysis. The results 
   demonstrated that the pain relief rate of experimental group (WAA / WAA + drug 
   intervention) was better than that of control group (analgesic drug 
   intervention), and the difference was statistically significant [RR = 1.31, 
   95%CI: 1.15 ~ 1.49, P < 0.01]. CONCLUSIONS: WAA has certain effect on cancer 
   pain, and the effect of WAA combined with pharmacological intervention is better 
   than that of drug therapy alone.
C1 Oncology Department of the First Affiliated Hospital of Soochow University, No. 188 Shizi Road, Suzhou, 215006, China.
   School of Nursing, Medical College of Soochow University, No. 188 Shizi Road, Suzhou, 215006, China.
   Oncology Department of the First Affiliated Hospital of Soochow University, No. 188 Shizi Road, Suzhou, 215006, China.
   School of Nursing, Medical College of Soochow University, No. 188 Shizi Road, Suzhou, 215006, China.
   Oncology Department of the First Affiliated Hospital of Soochow University, No. 188 Shizi Road, Suzhou, 215006, China.
   Radiotherapy Department of the First Affiliated Hospital of Soochow University, Suzhou, China.
   Oncology Department of the First Affiliated Hospital of Soochow University, No. 188 Shizi Road, Suzhou, 215006, China. tianlisz@suda.edu.cn.
   School of Nursing, Medical College of Soochow University, No. 188 Shizi Road, 
NR 0
TC 0
SN 2662-767
EI 
J9 BMC Complement Med Ther
PD JAN 9
PY 2021
VL 21
IS 1
BP 24
EP 24
DI 10.1186/s12906-020-03193-y 
PG 0
WC Acupuncture Points; Acupuncture Therapy; methods; Adult; Aged; Aged, 80 and over; Ankle; Bias; Cancer Pain; therapy; Female; Humans; Male; Middle Aged; Pain Management; methods; Pain Measurement; Wrist; Young Adult
UT PubMed:33413347
PM 33413347
DA 2021-01-09
ER

PT J
AU Qi, L
   Shi, H
   Zhang, Y
   Zhang, X
   Jia, H
   Tian, H
AF Qi, Lin
   Shi, Hongshuo
   Zhang, Yunsong
   Zhang, Xuecheng
   Jia, Hongling
   Tian, Hu
TI The effect of acupuncture on recovery after colorectal cancer resection: A 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: To evaluate the efficacy and safety of acupuncture by systematically 
   reviewing the literature on colorectal cancer resection. METHODS: Seven 
   electronic databases were searched from inception to February 28, 2023. 
   Randomized controlled trials on acupuncture in patients after CRC resection were 
   included. Two reviewers independently selected relevant trials, extracted data, 
   and assessed the risk of bias. A random-effects meta-analysis model was used to 
   obtain summary effect estimates. The data were pooled and analyzed using RevMan 
   5.3. The heterogeneity of selected studies was evaluated by evaluating the 
   I-squared (I2) statistics. RESULTS: Twenty-two studies with 1878 patients were 
   included. Results of the meta-analysis showed there was a low level evidence that 
   acupuncture may improve early postoperative symptoms, such as time to first 
   flatus (n = 876, MD -0.77h, 95% CI -1.22 to -0.33 h, I2 = 89%), time to first 
   bowel movement (n = 671, MD -1.41h, 95% CI -2.20 to -0.63 h, I2 = 95%), time to 
   first defecation (n = 556, MD -1.03h, 95% CI -1.88 to -0.18 h, I2 = 95%), and 
   nausea/vomiting (n = 1488, RR 0.72, 95% CI 0.59-0.89, I2 = 49%) compared with 
   usual care and sham acupuncture. However, there were no statistically significant 
   differences in postoperative pain (n = 1188, MD-0.21, 95% CI -0.59 to 0.17, I2 = 
   74%). And there was no sufficient evidence of improving long-term functional 
   outcomes. There was substantial heterogeneity across trials. The adverse events 
   associated with acupuncture stimulation were minor in include studies. CONCLUSION 
   SUBSECTIONS: There is currently low-level evidence supporting the use of 
   acupuncture on postoperative symptoms for patients after colorectal cancer 
   resection. More investigations should be established based on the STRICTA 
   statement strictly.
C1 College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
   College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
   The First Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
   Beijing University of Chinese Medicine, Beijing, China.
   The Second Affiliated Hospital of Shandong University of traditional Chinese Medicine, Jinan, China.
   College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD SEP 1
PY 2023
VL 102
IS 35
BP e34678
EP e34678
DI 10.1097/MD.0000000000034678 
PG 1
WC Humans; Randomized Controlled Trials as Topic; Acupuncture Therapy; Pain, Postoperative; Databases, Factual; Colorectal Neoplasms; surgery
UT PubMed:37657054
PM 37657054
DA 2023-09-01
ER

PT J
AU Chen, Q
   HongMei, M
   Yi, L
AF Chen, Qiuyu
   HongMei, Ma
   Yi, Liu
TI Acupoint Application Combined with Acupressure as an Adjunctive Therapy for 
SO Journal of visualized experiments : JoVE
LA English
DT Journal Article
AB Chemotherapy-induced nausea and vomiting (CINV) refers to the nausea and vomiting 
   experienced by patients after the application of chemotherapy drugs, 
   significantly affecting their quality of life and physical recovery, as well as 
   increasing the pain of the patients. Basic medicine primarily focuses on acid 
   suppression, gastric protection, and vomiting suppression, but there are still 
   many patients with nausea and vomiting symptoms that cannot be alleviated. 
   Traditional Chinese medicine (TCM) can effectively alleviate nausea and vomiting 
   through acupoint stimulation and pressure, while also offering advantages such as 
   simplicity, affordability, and fewer side effects. The aim of this article is to 
   introduce the method of using acupoint application combined with acupressure as 
   an adjunctive therapy for CINV, using the Multinational Association of Supportive 
   Care in Cancer (MASCC) Antiemesis Tool (MAT) tablet scale as a questionnaire. The 
   article details aspects such as acupoint selection, production, and the use of 
   acupoint application, massage techniques, and operating procedures, all with the 
   goal of ensuring the safety and efficacy of acupoint application combined with 
   acupressure as an adjuvant therapy, thereby improving patients' clinical symptoms 
   and quality of life.
C1 Chengdu University of Traditional Chinese Medicine
   chenqiuyu@stu.cdutcm.edu.cn.
   Oncology Department of Chengdu First People's Hospital.
   Chengdu University of Traditional Chinese Medicine.
NR 0
TC 0
SN 1940-087
EI 
J9 J Vis Exp
PD JUL 8
PY 2024
VL 0
IS 208
BP 
EP 
DI 10.3791/66865 
PG 0
WC Humans; Nausea; therapy; Vomiting; therapy; Acupressure; methods; Acupuncture Points; Antineoplastic Agents; adverse effects
UT PubMed:38975748
PM 38975748
DA 2024-07-08
ER

PT J
AU Bae, K
   Yoo, HS
   Lamoury, G
   Boyle, F
   Rosenthal, DS
   Oh, B
AF Bae, Kyeore
   Yoo, Hwa-Seung
   Lamoury, Gillian
   Boyle, Frances
   Rosenthal, David S
   Oh, Byeongsang
TI Acupuncture for Aromatase Inhibitor-Induced Arthralgia: A Systematic Review.
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; aromatase inhibitors; arthralgia; breast cancer; joint pain; pain management
AB BACKGROUND: Aromatase inhibitors (AIs) are commonly used as adjunctive hormone 
   treatment for early breast cancer patients. The major side effect of AIs is 
   arthralgia, which affects adherence. Previous reviews suggested that acupuncture 
   is effective in the management of cancer-related pain. The aim of this review is 
   to evaluate the effects of acupuncture on arthralgia caused by AIs. METHODS: This 
   article examined randomized controlled trials (RCTs) measuring the effects of 
   acupuncture on joint symptoms caused by AIs within 8 medical databases till May 
   2014. The quality of the articles was evaluated according to the Cochrane risk of 
   bias (ROB) tool. RESULTS: Four RCTs were identified in medical journals. Two 
   studies were conducted with manual acupuncture and 2 studies were 
   electroacupuncture. The range of sample size was between 32 and 67. One RCT 
   showed significant improvement in the acupuncture group compared with the sham 
   control group and another RCT showed a statistical difference between the 
   electroacupuncture and waitlist group. The other 2 studies showed no statistical 
   differences between control and acupuncture groups. Two studies conducted blood 
   analysis to elucidate the mechanism of efficacy of acupuncture for arthralgia. 
   The 2 positive studies had a lower ROB and 2 studies had a high ROB. CONCLUSIONS: 
   The systematic review suggests that acupuncture has potential benefits to improve 
   arthralgia caused by AIs. However, further trials of adequate sample size, 
   appropriate control group, and longer follow-up are necessary to investigate the 
   efficacy of acupuncture in AI-induced arthralgia.
C1 Royal North Shore Hospital, Sydney Medical School, Sydney, New South Wales, Australia East-West Cancer Center, Dunsan Korean Medicine Hospital of DaejeonUniversity, Daejeon, Korea kyeorebae@gmail.com.
   East-West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University, Daejeon, Korea.
   Royal North Shore Hospital, Sydney Medical School, Sydney, New South Wales, Australia Mater Hospital, Sydney Medical School, Sydney, New South Wales,Australia.
   Mater Hospital, Sydney Medical School, Sydney, New South Wales, Australia.
   Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
   Royal North Shore Hospital, Sydney Medical School, Sydney, New South Wales, Australia Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
NR 0
TC 0
SN 1552-695
EI 
J9 Integr Cancer Ther
PD JUL 30
PY 2015
VL 14
IS 6
BP 496
EP 502
DI 10.1177/1534735415596573 
PG 6
WC Acupuncture Therapy; methods; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Female; Humans; Randomized Controlled Trials as Topic
UT PubMed:26220605
PM 26220605
DA 2015-07-30
ER

PT J
AU An, LX
   Chen, X
   Ren, XJ
   Wu, HF
AF An, Li-Xin
   Chen, Xue
   Ren, Xiu-Jun
   Wu, Hai-Feng
TI Electro-acupuncture decreases postoperative pain and improves recovery in 
SO The American journal of Chinese medicine
LA English
DT Journal Article
DE Appetite; Dizziness; Electro-Acupuncture; Postoperative Pain; Supratentorial Craniotomy
AB We performed this study to examine the effect of electro-acupuncture (EA) on 
   postoperative pain, postoperative nausea and vomiting (PONV) and recovery in 
   patients after a supratentorial tumor resection. Eighty-eight patients requiring 
   a supratentorial tumor resection were anesthetized with sevoflurane and randomly 
   allocated to a no treatment group (Group C) or an EA group (Group A). After 
   anesthesia induction, the patients in Group A received EA at LI4 and SJ5, at BL63 
   and LR3 and at ST36 and GB40 on the same side as the craniotomy. The stimulation 
   was continued until the end of the operation. Patient-controlled intravenous 
   analgesia (PCIA) was used for the postoperative analgesia. The postoperative pain 
   scores, PONV, the degree of dizziness and appetite were recorded. In the first 6 
   hours after the operation, the mean total bolus, the effective times of PCIA 
   bolus administrations and the VAS scores were much lower in the EA group (p < 
   0.05). In the EA group, the incidence of PONV and degree of dizziness and feeling 
   of fullness in the head within the first 24 hours after the operation was much 
   lower than in the control group (p < 0.05). In the EA group, more patients had a 
   better appetite than did the patients in group C (51.2% vs. 27.5%) (p < 0.05). 
   The use of EA in neurosurgery patients improves the quality of postoperative 
   analgesia, promotes appetite recovery and decreases some uncomfortable 
   sensations, such as dizziness and feeling of fullness in the head.
C1 Department of Anesthesia, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
NR 0
TC 0
SN 1793-685
EI 
J9 Am J Chin Med
PD AUG 30
PY 2014
VL 42
IS 5
BP 1099
EP 109
DI 10.1142/S0192415X14500682 
PG -990
WC Adolescent; Adult; Analgesia, Patient-Controlled; statistics & numerical data; Craniotomy; Dizziness; prevention & control; Electroacupuncture; methods; Female; Humans; Male; Middle Aged; Pain, Postoperative; therapy; Postoperative Complications; prevention & control; Postoperative Nausea and Vomiting; prevention & control; Supratentorial Neoplasms; surgery; Young Adult
UT PubMed:25169910
PM 25169910
DA 2014-08-30
ER

PT J
AU Sharif, Nia H
   Pahlevan, Sharif S
   Yaghoobzadeh, A
   Yeoh, KK
   Goudarzian, AH
   Soleimani, MA
   Jamali, S
AF Sharif Nia, Hamid
   Pahlevan Sharif, Saeed
   Yaghoobzadeh, Ameneh
   Yeoh, Ken Kyid
   Goudarzian, Amir Hossein
   Soleimani, Mohammad Ali
   Jamali, Saman
TI Effect of acupressure on pain in Iranian leukemia patients: A randomized 
SO International journal of nursing practice
LA English
DT Journal Article
DE Iran; acupressure; cancer; leukemia; nursing; pain
AB Nonpharmacological methods of pain relief such as acupressure are becoming 
   increasingly popular worldwide. Practitioners often claim that such methods are 
   highly effective and less invasive than analgesic drugs, but available empirical 
   evidence is largely inconclusive. This study aimed to test the hypothesis that, 
   postacupressure intervention, the amount of pain experienced by sampled leukemia 
   patients, who received acupressure in addition to standard care, will reduce 
   substantially compared to patients who received only routine treatment. This 
   controlled trial was undertaken with hospitalized leukemia patients between 
   February and June 2015. Our primary sample consisted of 100 participants who were 
   randomly allocated to 2 groups. One (intervention) group underwent 12 acupressure 
   sessions in addition to standard treatment while the control group received no 
   intervention apart from being given the standard treatment for leukemia. The 
   visual analogue scale was used to measure the levels of pain experienced. No 
   significant differences were found between the 2 groups across 12 interventions. 
   However, each group reported significantly different pain level changes before 
   and after each intervention, suggested that the acupressure method was effective 
   in reducing pain in the short term. Nurses are able to apply this complementary 
   therapy alongside other procedures to manage these patients' pain. It is 
   recommended that further studies be conducted to better understand the specific 
   conditions under which acupressure can provide effective pain relief.
C1 School of Nursing and Midwifery Amol, Mazandaran University of Medical Sciences, Sari, Iran.
   Taylor's Business School, Subang Jaya, Malaysia.
   Tehran University of Medical Sciences, Tehran, Iran.
   Nottingham University Business School, University of Nottingham Malaysia Campus, Semenyih, Selangor Darul Ehsan, Malaysia.
   Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
   Social Determinants of Health Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
   Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
NR 0
TC 0
SN 1440-172
EI 
J9 Int J Nurs Pract
PD JAN 7
PY 2017
VL 23
IS 2
BP 
EP 
DI 10.1111/ijn.12513 
PG 0
WC Acupressure; Adult; Cancer Pain; diagnosis; Female; Humans; Iran; Leukemia; complications; Male; Middle Aged; Pain Measurement; Single-Blind Method
UT PubMed:28058748
PM 28058748
DA 2017-01-07
ER

PT J
AU Deng, G
   Cassileth, B
AF Deng, Gary
   Cassileth, Barrie
TI Acupuncture in cancer care.
SO Oncology (Williston Park, N.Y.)
LA English
DT Journal Article
NR 0
TC 0
SN 
EI 0890-909
J9 Oncology (Williston Park)
PD JUL 1
PY 2011
VL 25
IS 7 Suppl Nurse Ed
BP 
EP 
DI 
PG 0
WC Acupuncture Therapy; Hot Flashes; etiology; Humans; Nausea; etiology; Neoplasms; complications; Oncology Nursing; methods; Pain; etiology; Practice Guidelines as Topic; Risk Factors; Vomiting; etiology; Xerostomia; etiology
UT PubMed:25373274
PM 25373274
DA 2011-07-01
ER

PT J
AU Zhao, Q
   Zheng, S
   Delaney, GP
   Moylan, E
   Agar, MR
   Koh, ES
   Lai, H
   Birling, Y
   Zhang, GS
   Wang, K
   Ma, Y
   Zhu, X
AF Zhao, Qi
   Zheng, Suyang
   Delaney, Geoff P
   Moylan, Eugene
   Agar, Meera R
   Koh, Eng-Siew
   Lai, Hezheng
   Birling, Yoann
   Zhang, George Shengxi
   Wang, Kang
   Ma, Yong
   Zhu, Xiaoshu
TI Acupuncture for Cancer Related Pain: Protocol for a Pragmatic Randomised 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; cancer related pain; clinical trial; complementary and alternative medicine; pragmatic
AB BACKGROUND: Acupuncture has been proved effective for cancer related pain (CRP) 
   in China, America and some other countries. However, there is relative lack of 
   evidence to support the use of acupuncture for CRP in Australia. OBJECTIVES: To 
   assess the effectiveness and safety of acupuncture for management of CRP in a 
   real-world setting and to understand cancer patients' experience of undergoing 
   acupuncture for CRP. METHODS: A pragmatic randomised controlled trial will be 
   conducted in South Western Sydney Local Health District (SWSLHD) in NSW, 
   Australia. Adults with cancer related pain (n = 106) will be randomised in a 1:1 
   ratio to receive the acupuncture intervention up front versus after a wait list 
   period of 4 weeks. Pain level (by Numerical Rating Scale), analgesic use, 
   auricular acupressure frequency and adverse events will be assessed at baseline, 
   mid-treatment and post-treatment. Expectancy on trial outcome (by Credibility and 
   Expectancy questionnaire) will be assessed at baseline. The perspective of the 
   participants (by an interview) will be recorded after the last intervention. 
   EXPECTED OUTCOMES: We hypothesise that acupuncture will relieve cancer related 
   pain at mid-treatment and post-treatment. We also hypothesise that few adverse 
   events will be provoked by acupuncture. TRIAL REGISTRATION: Australia New-Zealand 
   Clinical Trial Registry (ACTRN12620000325909).
C1 Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
   Chinese Medicine Centre, Western Sydney University, NSW, Australia.
   Chinese Medicine Centre, Western Sydney University, NSW, Australia.
   Nanjing University of Chinese Medicine, Nanjing, China.
   University of NSW, Australia.
   South Western Sydney Local Health District, NSW, Australia.
   South Western Sydney Local Health District, NSW, Australia.
   University of Technology Sydney, NSW, Australia.
   University of NSW, NSW, Australia.
   South Western Sydney Local Health District, NSW, Australia.
   Chinese Medicine Centre, Western Sydney University, NSW, Australia.
   Chinese Medicine Centre, Western Sydney University, NSW, Australia.
   Chinese Medicine Centre, Western Sydney University, NSW, Australia.
   Chinese Medicine Centre, Western Sydney University, NSW, Australia.
   Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, China.
   Nanjing University of Chinese Medicine, Nanjing, China.
   Affiliated Hospital of Nanjing University of Chinese Medicine.
   Chinese Medicine Centre, Western Sydney University, NSW, Australia.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD DEC 11
PY 2020
VL 19
IS 
BP 1534735420976579
EP 1534735420976579
DI 10.1177/1534735420976579 
PG 1
WC Acupressure; Acupuncture Therapy; Adult; Analgesics; Cancer Pain; therapy; Humans; Neoplasms; therapy; Randomized Controlled Trials as Topic; Surveys and Questionnaires; Treatment Outcome; Pragmatic Clinical Trials as Topic
UT PubMed:33300382
PM 33300382
DA 2020-12-11
ER

PT J
AU Booher, A
   Mao, JJ
   Muniz, RC
   Romero, SAD
   Li, SQ
   Lopez, AM
   Liou, KT
AF Booher, Allison
   Mao, Jun J
   Muniz, Rosario Costas
   Romero, Sally A D
   Li, Susan Q
   Lopez, Ana Maria
   Liou, Kevin T
TI Association between Hispanic Ethnicity and Greater Expectation of Benefit from 
SO Journal of immigrant and minority health
LA English
DT Journal Article
DE Acupuncture; Cancer; Ethnic disparities; Health equity; Hispanic; Integrative medicine; Latina; Latino; Massage; Pain
AB Individuals living with cancer and survivors of cancer who self-identify as 
   Hispanic experience higher pain burden and greater barriers to pain management 
   compared with their non-Hispanic counterparts. The Society for Integrative 
   Oncology-ASCO guideline recommends acupuncture and massage for cancer pain 
   management. However, Hispanic individuals' expectations about these modalities 
   remain under-studied and highlight a potential barrier to treatment utilization 
   in this population. We conducted a subgroup analysis of baseline data from two 
   randomized clinical trials to evaluate ethnic differences in treatment 
   expectations about integrative pain treatment modalities among Hispanic and 
   non-Hispanic cancer patients and survivors of cancer. The Mao Expectancy of 
   Treatment Effects (METE) instrument was used to measure treatment expectancy for 
   electro-acupuncture, auricular acupuncture, and massage therapy. Results of this 
   study demonstrated that Hispanic participants reported greater expectation of 
   benefit from electroacupuncture, auricular acupuncture, and massage (all 
   P < 0.01). After controlling for age, gender, race, and education, Hispanic 
   ethnicity remained significantly associated with greater expectation of benefit 
   from integrative therapies for pain (coef.=1.47, 95% CI, 0.67-2.27). Non-white 
   race (coef.=1.04, 95% CI, 0.42-1.65), no college education (coef.=1.16, 95% CI, 
   0.59-1.74), and female gender (coef.=0.94, 95% CI, 0.38-1.50) were also 
   associated with a greater expectation of benefit from integrative therapies. Pain 
   management should be informed by a shared decision-making approach that aligns 
   treatment expectancy with treatment selections to optimize outcomes. Compared 
   with non-Hispanic participants, Hispanic individuals reported higher expectation 
   of benefit from acupuncture and massage, highlighting the potential role for 
   integrative therapies in addressing ethnic pain disparities. Trial Registration 
   NCT02979574 NCT04095234.
C1 Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
   Integrative Medicine Service, Department of Medicine, Bendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, 321 East 61st Street,New York, NY, 10065, USA.
   Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, CA, USA.
   Integrative Medicine Service, Department of Medicine, Bendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, 321 East 61st Street,New York, NY, 10065, USA.
   Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
   Integrative Medicine Service, Department of Medicine, Bendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, 321 East 61st Street,New York, NY, 10065, USA. liouk@mskcc.org.
NR 0
TC 0
SN 1557-192
EI 1557-191
J9 J Immigr Minor Health
PD JUL 9
PY 2024
VL 26
IS 5
BP 953
EP 957
DI 10.1007/s10903-024-01611-8 
PG 4
WC Adult; Aged; Female; Humans; Male; Middle Aged; Acupuncture Therapy; Acupuncture, Ear; Cancer Pain; therapy; Hispanic or Latino; Massage; Neoplasms; ethnology; Pain Management; methods; Sex Factors; Socioeconomic Factors
UT PubMed:38977653
PM 38977653
DA 2024-07-09
ER

PT J
AU Lin, TY
   Hsieh, CL
AF Lin, Ting-Yen
   Hsieh, Ching-Liang
TI Clinical Applications of Bee Venom Acupoint Injection.
SO Toxins
LA English
DT Journal Article
DE acupoint injections; bee venom; clinical application; pharmacological mechanism
AB Bee venom is a complex natural mixture with various pharmaceutical properties. 
   Among these properties, its peptides and enzymes have potential medical therapy 
   for pain relief and inflammation. In clinical settings, this therapy has been 
   used widely to treat diseases by injecting into acupoints. In this article, we 
   have conducted various research from PubMed, Cochrane Library, and Clinical Key 
   from inception of July 2020. The results revealed that bee venom therapy has been 
   reported effective in anti-inflammatory, antiapoptosis, and analgesic effects. 
   Moreover, bee venom acupuncture has been commonly used for clinical disorders 
   such as Parkinson disease, neuropathic pain, Alzheimer disease, intervertebral 
   disc disease, spinal cord injury, musculoskeletal pain, arthritis, multiple 
   sclerosis, skin disease and cancer.
C1 Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan.
   Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan.
   Graduate Institute of Acupuncture Science, College of Chinese Medicine, China 
   Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan.
NR 0
TC 0
SN 2072-665
EI 
J9 Toxins (Basel)
PD OCT 1
PY 2020
VL 12
IS 10
BP 
EP 
DI 10.3390/toxins12100618 
PG 0
WC Acupuncture Points; Acupuncture Therapy; adverse effects; Animals; Bee Venoms; administration & dosage; Disease Models, Animal; Humans; Injections; Treatment Outcome
UT PubMed:32992601
PM 32992601
DA 2020-10-01
ER

PT J
AU Meng, FF
   Feng, YH
AF Meng, Fan-Feng
   Feng, Yan-Hong
TI A pilot study of acupuncture at pain acupoints for cervical cancer pain.
SO Medicine
LA English
DT Journal Article
AB This retrospective study aimed to investigate the feasible effectiveness of 
   acupuncture at pain acupoints for the treatment of patients with cervical cancer 
   pain (CCP). A total of 64 cases were analyzed. All these cases were assigned to 
   an acupuncture group or a control group according to the different therapies they 
   received. The cases in the acupuncture group received acupuncture treatment at 
   pain acupoints, while the subjects in the control group underwent acupuncture at 
   regular acupoints. The primary endpoint was CCP, assessed by numeric rating scale 
   (NRS). The secondary endpoints were evaluated by the European Organization for 
   Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC 
   QLQ-C30), and Karnofsky Performance Status (KPS). In addition, adverse events 
   were also recorded during the treatment period. After treatment, patients in the 
   acupuncture group exerted greater outcomes in CCP reduction when compared with 
   patients in the control group (P < .01). In addition, no adverse events were 
   recorded in either group. The results of this study showed that acupuncture at 
   pain acupoints might be efficacious in patients with CCP after 14-day treatment.
C1 Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD DEC 30
PY 2018
VL 97
IS 52
BP e13736
EP e13736
DI 10.1097/MD.0000000000013736 
PG 1
WC Acupuncture Points; Acupuncture Therapy; methods; Cancer Pain; etiology; Feasibility Studies; Female; Humans; Karnofsky Performance Status; Middle Aged; Pilot Projects; Quality of Life; Retrospective Studies; Surveys and Questionnaires; Treatment Outcome; Uterine Cervical Neoplasms; complications
UT PubMed:30593148
PM 30593148
DA 2018-12-30
ER

PT J
AU Tian, SX
   Xu, T
   Shi, RY
   Cai, YQ
   Wu, MH
   Zhen, SJ
   Wang, W
   Zhou, Y
   Du, JY
   Fang, JF
   Shao, XM
   Liu, BY
   Jiang, YL
   He, XF
   Fang, JQ
   Liang, Y
AF Tian, Shu-Xin
   Xu, Ting
   Shi, Ren-Yi
   Cai, Yang-Qian
   Wu, Ming-Hui
   Zhen, Si-Jia
   Wang, Wen
   Zhou, You
   Du, Jun-Ying
   Fang, Jun-Fan
   Shao, Xiao-Mei
   Liu, Bo-Yi
   Jiang, Yong-Liang
   He, Xiao-Fen
   Fang, Jian-Qiao
   Liang, Yi
TI Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role 
SO Purinergic signalling
LA English
DT Journal Article
DE Bone cancer-induced pain; DRG; Electroacupuncture; P2X3 receptor
AB Upregulation of P2X3 receptor (P2X3R) has been strongly implicated in nociceptive 
   signaling including bone cancer pain (BCP). The present study, using rat bone 
   cancer model, aimed to explore the role of P2X3R in regulating rat pain behavior 
   under the intervention of electroacupuncture (EA). The BCP model was successfully 
   established by injection with MRMT-1 breast cancer cell into the medullary cavity 
   of left tibia for 3 × 10(4) cells/3 μL PBS in rats as revealed by obvious bone 
   destruction, decreased paw withdrawal thresholds (PWTs), and reduced paw 
   withdrawal latencies (PWLs). Western blot analyses showed that P2X3R expression 
   was significantly upregulated in ipsilateral lumbar 4-6 (L4-6) dorsal root 
   ganglia (DRG), but the difference not seen in spinal cord dorsal horn (SCDH). 
   With the in-depth study of P2X3R activation, we observed that intrathecal 
   injection of P2X3R agonist α,β-meATP aggravated MRMT-1 induced BCP, while 
   injection of P2X3R inhibitor A-317491 alleviated pain. Subsequently, we 
   demonstrated that BCP induced mechanical allodynia and thermal hyperalgesia were 
   attenuated after EA treatment. Under EA treatment, total P2X3R protein expression 
   in ipsilateral DRGs was decreased, and it is worth mentioning that decreased 
   expression of P2X3R membrane protein, which indicated that both the expression 
   and membrane trafficking of P2X3R were inhibited by EA. The immunofluorescence 
   assay showed that EA stimulation exerted functions by reducing the expression of 
   P2X3R-positive cells in ipsilateral DRGs of BCP rats. Ca(2+) imaging analysis 
   revealed that the EA stimulation decreased the percentage of α,β-meATP responsive 
   neurons in DRGs and inhibited calcium influx. Notably, the inhibitory effect of 
   EA on mechanical allodynia and nociceptive flinches was abolished by intrathecal 
   injection of α,β-meATP. These findings demonstrated EA stimulation ameliorated 
   mechanical allodynia and thermal hyperalgesia in rat model of MRMT-1-induced BCP. 
   EA exerts analgesic effect on BCP by reducing the overexpression and functional 
   activity of P2X3R in ipsilateral DRGs of BCP rats. Our work first demonstrates 
   the critical and overall role of P2X3R in EA's analgesia against peripheral 
   sensitization of MRMT-1-induced BCP and further supports EA as a potential 
   therapeutic option for cancer pain in clinic.
C1 Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Acupuncture and Moxibustion, Sanya Traditional Chinese Medicine Hospital, Sanya, 572000, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of 
   Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medicine, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District,Hangzhou, 310053, Zhejiang Province, China. liangyiwww@126.com.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of 
NR 0
TC 0
SN 1573-954
EI 1573-953
J9 Purinergic Signal
PD APR 29
PY 2022
VL 19
IS 1
BP 13
EP 27
DI 10.1007/s11302-022-09861-7 
PG 14
WC Rats; Animals; Hyperalgesia; metabolism; Cancer Pain; metabolism; Receptors, Purinergic P2X3; metabolism; Rats, Sprague-Dawley; Electroacupuncture; methods; Pain; metabolism; Bone Neoplasms; metabolism; Analgesics; Ganglia, Spinal; metabolism
UT PubMed:35478452
PM 35478452
DA 2022-04-29
ER

PT J
AU Ng, DQ
   Lee, S
   Lee, RT
   Wang, Y
   Chan, A
AF Ng, Ding Quan
   Lee, Sanghoon
   Lee, Richard T
   Wang, Yun
   Chan, Alexandre
TI Real-world impact of acupuncture on analgesics and healthcare resource 
SO BMC medicine
LA English
DT Journal Article
DE Acupuncture; Cancer pain; Claims data; Difference-in-difference; Propensity score; Real-world evidence
AB BACKGROUND: This study evaluated the real-world impact of acupuncture on 
   analgesics and healthcare resource utilization among breast cancer survivors. 
   METHODS: From a United States (US) commercial claims database (25% random sample 
   of IQVIA PharMetrics® Plus for Academics), we selected 18-63 years old malignant 
   breast cancer survivors experiencing pain and ≥ 1 year removed from cancer 
   diagnosis. Using the difference-in-difference technique, annualized changes in 
   analgesics [prevalence, rates of short-term (< 30-day supply) and long-term 
   (≥ 30-day supply) prescription fills] and healthcare resource utilization 
   (healthcare costs, hospitalizations, and emergency department visits) were 
   compared between acupuncture-treated and non-treated patients. RESULTS: Among 495 
   (3%) acupuncture-treated patients (median age: 55 years, stage 4: 12%, average 
   2.5 years post cancer diagnosis), most had commercial health insurance (92%) and 
   experiencing musculoskeletal pain (98%). Twenty-seven percent were receiving 
   antidepressants and 3% completed ≥ 2 long-term prescription fills of opioids. 
   Prevalence of opioid usage reduced from 29 to 19% (P < 0.001) and NSAID usage 
   reduced from 21 to 14% (P = 0.001) post-acupuncture. The relative prevalence of 
   opioid and NSAID use decreased by 20% (P < 0.05) and 19% (P = 0.07), 
   respectively, in the acupuncture-treated group compared to non-treated patients 
   (n = 16,129). However, the reductions were not statistically significant after 
   adjustment for confounding. Patients receiving acupuncture for pain (n = 264, 
   53%) were found with a relative decrease by 47% and 49% (both P < 0.05) in 
   short-term opioid and NSAID fills compared to those treated for other conditions. 
   High-utilization patients (≥ 10 acupuncture sessions, n = 178, 36%) were observed 
   with a significant reduction in total healthcare costs (P < 0.001) unlike 
   low-utilization patients. CONCLUSIONS: Although adjusted results did not show 
   that patients receiving acupuncture had better outcomes than non-treated 
   patients, exploratory analyses revealed that patients treated specifically for 
   pain used fewer analgesics and those with high acupuncture utilization incurred 
   lower healthcare costs. Further studies are required to examine acupuncture 
   effectiveness in real-world settings.
C1 School of Pharmacy & Pharmaceutical Sciences, University of California Irvine, 802 W Peltason Dr, Irvine, CA, 92697-4625, USA.
   School of Pharmacy, Chapman University, RK 94-206, 9401 Jeronimo Road, Irvine, 
   College of Korean Medicine, Kyung Hee University, Seoul, South Korea.
   Integrative Medicine Program, Departments of Supportive Care Medicine and Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
   School of Pharmacy, Chapman University, RK 94-206, 9401 Jeronimo Road, Irvine, CA, 92618, USA. yunwang@chapman.edu.
   School of Pharmacy & Pharmaceutical Sciences, University of California Irvine, 802 W Peltason Dr, Irvine, CA, 92697-4625, USA. a.chan@uci.edu.
NR 0
TC 0
SN 1741-701
EI 
J9 BMC Med
PD SEP 17
PY 2024
VL 22
IS 1
BP 394
EP 394
DI 10.1186/s12916-024-03626-2 
PG 0
WC Humans; Middle Aged; Female; Breast Neoplasms; therapy; Cancer Survivors; Adult; Acupuncture Therapy; economics; Analgesics; therapeutic use; Patient Acceptance of Health Care; statistics & numerical data; United States; epidemiology; Young Adult; Adolescent; Pain Management; methods; Cancer Pain; therapy
UT PubMed:39285302
PM 39285302
DA 2024-09-17
ER

PT J
AU Widgren, Y
   Fransson, P
   Efverman, A
AF Widgren, Ylva
   Fransson, Per
   Efverman, Anna
TI Acupuncture in Patients Undergoing Cancer Therapy: Their Interest and Belief in 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture therapy; attitudes; cancer survivors; complementary and alternative medicine; expectations; oncology nursing
AB OBJECTIVES: Since pre-existing expectations, that is, beliefs, in a treatment may 
   modify outcomes, and acupuncture studies often fail to measure expectations, we 
   wanted to investigate the use of acupuncture, interest, and belief in acupuncture 
   effects among patients undergoing cancer therapy. METHOD: A cross-sectional 
   design, where the participants answered a study-specific questionnaire with 
   questions regarding their use of, interest and belief in acupuncture treatment. 
   RESULTS: A total of 457 patients with cancer (48% men, mean age 65 years) 
   answered the questionnaire. Acupuncture was used by 4 (1%) patients during their 
   cancer therapy, and 368 (83%) expressed an interest in receiving acupuncture. Of 
   the 457 patients, 289 (63%) believed acupuncture to be effective for at least 1 
   of 17 requested symptoms, most commonly pain (56% of the patients) and muscle 
   tension (40%). They believed acupuncture to be effective for a mean value 3 of 
   the 17 requested symptoms. Women (P < .001), and patients 41 to 65 years 
   (P < .001), expressed a stronger belief in acupuncture effects than others. 
   CONCLUSIONS: Men and older patients expressed weaker beliefs in acupuncture 
   effects than other patients, indicating the importance of collecting expectancy 
   data in future randomized sham-controlled acupuncture studies to be able to treat 
   expectancy as an effect-modifier. The high interest and beliefs in acupuncture 
   effects found also indicate that acupuncture should be available for patients 
   with cancer, for side effects where acupuncture has shown to be effective. In a 
   clinical setting, older men might need more encouragement regarding positive 
   expected outcomes of the acupuncture treatment than younger women.
C1 University of Gävle, Gavle, Sweden.
   Region Hospital of Sundsvall-Härnösand, County Council of Västernorrland, 
   Umeå University, Umeå, Sweden.
   Umeå University Hospital, Umeå, Sweden.
   University of Gävle, Gavle, Sweden.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD FEB 26
PY 2022
VL 21
IS 
BP 15347354221077277
EP 15347354221077277
DI 10.1177/15347354221077277 
PG 1
WC Acupuncture; Acupuncture Therapy; Aged; Cross-Sectional Studies; Female; Humans; Male; Neoplasms; therapy; Pain; etiology
UT PubMed:35212241
PM 35212241
DA 2022-02-26
ER

PT J
AU Hay, W
AF Hay, William
TI Sham procedure inadequate.
SO Cancer
LA English
DT Letter
C1 Department of Family Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
NR 0
TC 0
SN 1097-014
EI 
J9 Cancer
PD JAN 8
PY 2015
VL 121
IS 7
BP 1148
EP 1148
DI 10.1002/cncr.29114 
PG 0
WC Anxiety; therapy; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Depression; therapy; Electroacupuncture; methods; Fatigue; therapy; Female; Humans; Sleep Wake Disorders; therapy
UT PubMed:25565320
PM 25565320
DA 2015-01-08
ER

PT J
AU Wei, W
   Yao, B
   Sun, X
   Xing, S
   Wang, K
   He, F
   Xu, Q
   Ren, C
AF Wei, Wei
   Yao, Bei
   Sun, Xiaoying
   Xing, Shaona
   Wang, Kaiyi
   He, Fangmei
   Xu, Qiaobo
   Ren, Chunxiao
TI Invasive or noninvasive? A systematic review and network meta-analysis of 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupressure; Acupuncture; Cancer pain; Complementary therapies; Network meta-analysis
AB BACKGROUND: Both acupressure and acupuncture effectively alleviate pain in cancer 
   patients. Acupuncture requires specialized practitioners and is invasive, while 
   acupressure is noninvasive and can be self-administered. Current comparative 
   evidence remains insufficient for clear clinical recommendations. AIMS: To 
   investigate the relative efficacy of acupuncture versus acupressure in 
   alleviating pain among cancer patients. METHODS: This systematic review and 
   network meta-analysis employed a Bayesian framework. Eight major Chinese and 
   English databases were searched from inception to March 1, 2025. Two independent 
   reviewers screened literature, extracted data, and assessed bias in selected 
   studies using the Risk of Bias 2 tool. Network meta-analysis was conducted using 
   R software version 4.4.1. RESULTS: Thirty-seven RCTs including 3066 patients were 
   analyzed to compare eight treatments: manual acupuncture, transcutaneous 
   electrical acupoint stimulation, auricular acupressure, electro-acupuncture, 
   acupoint massage, auricular acupuncture, moxibustion, and placebo. Network 
   meta-analysis revealed auricular acupuncture provided the greatest pain score 
   improvement compared to placebo, followed by auricular acupressure and acupoint 
   massage. CONCLUSION: Based on our analysis, we recommend auricular acupuncture, 
   auricular acupressure, and acupoint massage for managing cancer pain. While 
   current studies demonstrate potential benefits, limitations include concurrent 
   pain medication use and methodological inconsistencies. Future research should 
   include more robust, single-intervention clinical trials to definitively evaluate 
   efficacy for oncology patients.
C1 Shaanxi Energy Institute, Xianyang City, 712000, Shaanxi Province, China.
   China Academy of Chinese Medical Sciences, Institute of Basic Research in Clinical Medicine, Beijing, China.
   Shaanxi Energy Institute, Xianyang City, 712000, Shaanxi Province, China.
   Shaanxi Energy Institute, Xianyang City, 712000, Shaanxi Province, China.
   Shaanxi Energy Institute, Xianyang City, 712000, Shaanxi Province, China.
   Shaanxi Energy Institute, Xianyang City, 712000, Shaanxi Province, China.
   Shaanxi Energy Institute, Xianyang City, 712000, Shaanxi Province, China.
   Shaanxi Energy Institute, Xianyang City, 712000, Shaanxi Province, China. 2215222801@qq.com.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD OCT 31
PY 2025
VL 33
IS 11
BP 997
EP 997
DI 10.1007/s00520-025-10068-w 
PG 0
WC Humans; Cancer Pain; therapy; Acupressure; methods; Acupuncture Therapy; methods; Randomized Controlled Trials as Topic; Neoplasms; complications; Bayes Theorem; Pain Management; methods
UT PubMed:41171390
PM 41171390
DA 2025-10-31
ER

PT J
AU Lam, WL
   Yeung, WF
   Wong, MK
   Cheung, CW
   Chan, KKL
   Ngan, HYS
   Wong, CKH
   Chen, HY
   Lao, L
AF Lam, Wing Lok
   Yeung, Wing Fai
   Wong, Mei Kuen
   Cheung, Chi Wai
   Chan, Karen Kar Loen
   Ngan, Hextan Yuen Sheung
   Wong, Carlos King Ho
   Chen, Hai Yong
   Lao, Lixing
TI Combined electroacupuncture and auricular acupuncture for postoperative pain 
SO Trials
LA English
DT Journal Article
DE AUC; Acupuncture; Analgesia; Health economic analysis; Morphine consumption; Operation; Placebo; RCT
AB BACKGROUND: Postoperative pain is a major complaint following abdominal surgery 
   for gynecological diseases. Effective postoperative pain control after abdominal 
   surgery is particularly important for patient recovery, mobility, and 
   satisfaction. Acupuncture has been commonly used for pain management. However, 
   its efficacy in postoperative pain control is inconclusive and health economic 
   evaluation is limited. METHODS: A randomized, sham-controlled, patient- and- 
   assessor-blind trial is designed to evaluate the efficacy and safety of 
   acupuncture in managing postoperative pain following abdominal surgery of 
   gynecological diseases. Patients who are eligible for laparotomy with a midline 
   incision for gynecological neoplasia, including ovarian mass, uterine mass, and 
   cervical lesions, will be recruited. Seventy-two participants will be randomly 
   allocated to an acupuncture or non-invasive sham control in a 1:1 ratio. 
   Treatment will be done within 2 h before operation, upon arrival to the ward and 
   once daily for 5 days. The Pain Numerical Rating Scale (NRS) on the first 5 days 
   during hospitalization will be the primary outcome and will be analyzed using the 
   area-under-the-curve (AUC) method. The secondary outcome measures include 
   frequency of rescue analgesic use during hospital stay, cumulative morphine 
   consumption; quality of recovery as measured by time to recovery variables and 
   the Quality of Recovery-9 (QoR-9); quality of life as measured by the Short 
   Form-6 dimension (SF-6D) and EuroQol-5 Dimension-5 Level (EQ-5D-5 L). The 
   incremental cost-effectiveness ratio of acupuncture vs sham acupuncture will be 
   calculated. DISCUSSION: This study protocol provides an example of integrative 
   medicine practice in a hospital setting for the management of postoperative pain 
   using acupuncture treatment. The acupuncture treatment protocol, if proven to be 
   effective, can be implemented in routine settings to play a role in postoperative 
   pain management for patients who have undergone abdominal surgery for 
   gynecological diseases. TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT02851186 . 
   Registered on 19 July 2016.
C1 School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, Special Administrative Region of China.
   School of Nursing, the Hong Kong Polytechnic University, Kowloon, Hong Kong, Special Administrative Region of China.
   School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, Special Administrative Region of China.
   Department of Anesthesiology, The University of Hong Kong, 4/F, K Block, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong, Special AdministrativeRegion of China.
   Department of Obstetrics and Gynecology, The University of Hong Kong, 6/F, Professorial Block, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong,Special Administrative Region of China.
   Department of Obstetrics and Gynecology, The University of Hong Kong, 6/F, Professorial Block, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong,Special Administrative Region of China.
   Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F, Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Pokfulam, Hong Kong, SpecialAdministrative Region of China.
   School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, Special Administrative Region of China.
   School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, Special Administrative Region of China. lxlao1@hku.hk.
NR 0
TC 0
SN 1745-621
EI 
J9 Trials
PD JAN 6
PY 2018
VL 19
IS 1
BP 8
EP 8
DI 10.1186/s13063-017-2359-8 
PG 0
WC Abdomen; surgery; Acupuncture, Ear; adverse effects; Analgesics; therapeutic use; Double-Blind Method; Electroacupuncture; adverse effects; Female; Genital Diseases, Female; surgery; Gynecologic Surgical Procedures; adverse effects; Hong Kong; Humans; Pain Measurement; Pain, Postoperative; diagnosis; Quality of Life; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome
UT PubMed:29301556
PM 29301556
DA 2018-01-06
ER

PT J
AU Bao, T
   Zhi, WI
   Baser, RE
   Li, QS
   Weitzman, M
   Gillespie, EF
   Robson, M
   Mao, JJ
AF Bao, Ting
   Zhi, W Iris
   Baser, Raymond E
   Li, Q Susan
   Weitzman, Matthew
   Gillespie, Erin F
   Robson, Mark
   Mao, Jun J
TI Electro-acupuncture versus battle field auricular acupuncture in breast cancer 
SO Breast cancer research and treatment
LA English
DT Journal Article
DE Acupuncture; Breast cancer; Pain; Quality of life
AB PURPOSE: Chronic musculoskeletal pain is common and debilitating among breast 
   cancer survivors. The PEACE trial demonstrated that electro-acupuncture (EA) and 
   battle field auricular acupuncture (BFAA) both reduced pain more than usual care 
   (UC) in cancer survivors. However, the comparative effectiveness between EA and 
   BFAA among breast cancer survivors is unknown. METHODS: EA and BFAA received ten 
   weekly treatments. UC was offered ten EA treatments after week 12. The primary 
   endpoint was change in mean Brief Pain Inventory (BPI) pain severity from 
   baseline to week 12. We analyzed the subset of 165 (46%) trial participants with 
   a breast cancer primary diagnosis. We conducted constrained linear mixed model 
   analyses, which constrained all arms to a common pre-randomization baseline mean. 
   Model-based mean estimates at weeks 12 and 24 were compared between arms using 
   model contrasts. RESULTS: Among 165 breast cancer survivors, common 
   pre-randomization mean pain severity was 5.35 [95% Confidence Interval (CI) 5.04, 
   5.66]. At week 12, BPI pain severity score was 2.69 (2.26. 3.13) in EA, 3.60 
   (3.17, 4.02) in BFAA, and 5.06 (4.47, 5.65) in UC. EA reduced pain severity 
   significantly more than BFAA at weeks 12 [- 0.90 (- 1.45, - 0.36), p = 0.001] and 
   24 [- 0.82, (- 1.38, - 0.27), p = 0.004]. EA and BFAA significantly improved both 
   Patient-Reported Outcomes Measurement Information System (PROMIS) - Global Health 
   physical health and mental health component scores at week 12 compared to UC. 
   Mild toxicities were reported. CONCLUSION: EA was more effective than BFAA at 
   reducing pain severity, but both similarly improved physical and mental health 
   scores. Breast cancer survivors with chronic musculoskeletal pain may consider EA 
   before BFAA. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02979574. 
   https://clinicaltrials.gov/ct2/show/NCT02979574.
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. tingbao@gmail.com.
   Breast Medicine Service, Solid Tumor Division, Department of Medicine, Memorial 
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 321 E. 61st Street, 4th Floor, New York, NY, 10065, USA.tingbao@gmail.com.
   Breast Medicine Service, Solid Tumor Division, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, USA.
   Breast Medicine Service, Solid Tumor Division, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
NR 0
TC 0
SN 1573-721
EI 0167-680
J9 Breast Cancer Res Treat
PD AUG 24
PY 2023
VL 202
IS 2
BP 287
EP 295
DI 10.1007/s10549-023-07072-1 
PG 8
WC Humans; Female; Breast Neoplasms; complications; Cancer Survivors; Musculoskeletal Pain; therapy; Acupuncture, Ear; Acupuncture Therapy
UT PubMed:37612534
PM 37612534
DA 2023-08-24
ER

PT J
AU Tang, Q
   Zhang, K
AF Tang, Qilin
   Zhang, Kai
TI Association of Acupuncture and Acupressure With Improved Cancer Pain.
SO JAMA oncology
LA English
DT Letter
C1 School of Basic Medical Sciences, Hebei University of Chinese Medicine, Shijiazhuang, China.
   Department of Acupuncture and Moxibustion, Tianjin Gong An Hospital, Tianjin, China.
NR 0
TC 0
SN 2374-244
EI 
J9 JAMA Oncol
PD APR 24
PY 2020
VL 6
IS 6
BP 938
EP 938
DI 10.1001/jamaoncol.2020.0616 
PG 0
WC Acupressure; Acupuncture Therapy; Cancer Pain; therapy; Humans; Neoplasms; complications
UT PubMed:32324212
PM 32324212
DA 2020-04-24
ER

PT J
AU Cai, DB
   Yuan, WQ
   Zheng, W
AF Cai, Dong-Bin
   Yuan, Wei-Qu
   Zheng, Wei
TI Association of Acupuncture and Acupressure With Improved Cancer Pain.
SO JAMA oncology
LA English
DT Letter
C1 Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China.
   Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China.
   The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, China.
NR 0
TC 0
SN 2374-244
EI 
J9 JAMA Oncol
PD APR 24
PY 2020
VL 6
IS 6
BP 939
EP 940
DI 10.1001/jamaoncol.2020.0622 
PG 1
WC Acupressure; Acupuncture Therapy; Cancer Pain; therapy; Humans; Neoplasms; complications
UT PubMed:32324193
PM 32324193
DA 2020-04-24
ER

PT J
AU Wang, B
   Lu, Z
   Huang, Y
AF Wang, Bolin
   Lu, Zhong
   Huang, Yan
TI Association of Acupuncture and Acupressure With Improved Cancer Pain.
SO JAMA oncology
LA English
DT Letter
C1 Weifang Medical University, Weifang, China.
   Department of Oncology, Affiliated Hospital of Weifang Medical University, Weifang, China.
   Department of Oncology, Affiliated Hospital of Weifang Medical University, Weifang, China.
NR 0
TC 0
SN 2374-244
EI 
J9 JAMA Oncol
PD APR 24
PY 2020
VL 6
IS 6
BP 938
EP 939
DI 10.1001/jamaoncol.2020.0619 
PG 1
WC Acupressure; Acupuncture Therapy; Cancer Pain; therapy; Humans; Neoplasms; complications
UT PubMed:32324200
PM 32324200
DA 2020-04-24
ER

PT J
AU He, Y
   May, BH
   Zhang, H
AF He, Yihan
   May, Brian H
   Zhang, Haibo
TI Association of Acupuncture and Acupressure With Improved Cancer Pain-Reply.
SO JAMA oncology
LA English
DT Letter
C1 Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy ofChinese Medical Sciences, Guangzhou, Guangdong Province, China.
   China-Australia International Research Centre for Chinese Medicine, School of 
   China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
   Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy ofChinese Medical Sciences, Guangzhou, Guangdong Province, China.
NR 0
TC 0
SN 2374-244
EI 
J9 JAMA Oncol
PD APR 24
PY 2020
VL 6
IS 6
BP 940
EP 940
DI 10.1001/jamaoncol.2020.0640 
PG 0
WC Acupressure; Acupuncture Therapy; Cancer Pain; therapy; Humans; Neoplasms; complications
UT PubMed:32324196
PM 32324196
DA 2020-04-24
ER

PT J
AU Chiu, HY
   Hsieh, YJ
   Tsai, PS
AF Chiu, H Y
   Hsieh, Y J
   Tsai, P S
TI Systematic review and meta-analysis of acupuncture to reduce cancer-related pain.
SO European journal of cancer care
LA English
DT Journal Article
DE acupuncture; cancer-related pain; meta-analysis
AB We conducted a systematic review and meta-analysis to evaluate the effects of 
   acupuncture on malignancy-related, chemotherapy (CT)- or radiation therapy 
   (RT)-induced, surgery-induced, and hormone therapy (HT)-induced pain. Randomised 
   controlled trials (RCTs) examining the effects of acupuncture on cancer-related 
   pain were reached from the EMBASE, PubMed, PsycINFO, Cochrane Central Register of 
   Controlled Trials, CINAHL, Airiti library, Taiwan Electrical Periodical Service, 
   Wanfang Data (a Chinese database) and China Knowledge Resource Integrated 
   Database from inception through June 2014. Heterogeneity, moderator analysis, 
   publication bias and risk of bias associated with the included studies were 
   examined. A total of 29 RCTs yielding 36 effect sizes were included. The overall 
   effect of acupuncture on cancer-related pain was -0.45 [95% confidence interval 
   (CI) = -0.63 to -0.26]. The subanalysis indicated that acupuncture relieved 
   malignancy-related and surgery-induced pain [effect size (g) = -0.71, and -0.40; 
   95% CI = -0.94 to -0.48, and -0.69 to -0.10] but not CT- or RT-induced and 
   HT-induced pain (g = -0.05, and -0.64, 95% CI = -0.33 to 0.24, and -1.55 to 
   0.27). Acupuncture is effective in relieving cancer-related pain, particularly 
   malignancy-related and surgery-induced pain. Our findings suggest that 
   acupuncture can be adopted as part of a multimodal approach for reducing 
   cancer-related pain.
C1 School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
   School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
   School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
NR 0
TC 0
SN 1365-235
EI 
J9 Eur J Cancer Care (Engl)
PD FEB 9
PY 2016
VL 26
IS 2
BP 
EP 
DI 10.1111/ecc.12457 
PG 0
WC Acupuncture Therapy; methods; Cancer Pain; therapy; Humans
UT PubMed:26853524
PM 26853524
DA 2016-02-09
ER

PT J
AU Li, X
   Lampson, K
   Rosa, WE
   Li, QS
   Ramalingam, MB
   Epstein, AS
   Mao, JJ
AF Li, Xiaotong
   Lampson, Kaitlin
   Rosa, William E
   Li, Q Susan
   Ramalingam, Mothi Babu
   Epstein, Andrew S
   Mao, Jun J
TI Effect of acupuncture on fatigue in cancer survivors with chronic pain: a 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture; Cancer survivors; Chronic pain; Clinical trial; Fatigue
AB PURPOSE: Fatigue is one of the most common and troublesome symptoms in cancer 
   survivors and is strongly correlated with pain. We evaluated the effect of 
   acupuncture versus usual care for fatigue among cancer survivors with chronic 
   pain. METHODS: We analyzed data from a randomized clinical trial comparing the 
   effect of electro-acupuncture (EA) or battlefield acupuncture (BFA) versus 
   waitlist control (WLC) for chronic musculoskeletal pain in cancer survivors. 
   Analysis included participants who reported moderate or severe fatigue at 
   baseline. Interventions were delivered over 10 weeks. Fatigue severity was 
   measured using the Brief Fatigue Inventory (BFI). RESULTS: Among 274 participants 
   (mean age 61.0 years [standard deviation (SD)] 12.8; 73.0% women), the baseline 
   BFI worst fatigue score was 7.1 (SD 1.7). EA and BFA were associated with 
   reductions in worst fatigue score of 2.4 points (95% confidence interval 
   [CI]: - 2.9 to - 1.9) and 2.0 points (95% CI: - 2.5 to - 1.5) from baseline to 
   week 12. There was no significant between-group difference. A higher proportion 
   of patients in both EA and BFA experienced clinically meaningful fatigue 
   improvement compared to WLC (61.2% and 51.6% vs. 37.3%, p = 0.019). Fatigue 
   reductions persisted at week 24 (EA: -2.1 points [95% CI: -2.6 to -1.7]; BFA: 
   -2.2 points [95% CI: -2.8 to -1.7]). CONCLUSION: Cancer survivors with chronic 
   pain experienced clinically meaningful and durable fatigue reductions when 
   receiving either EA or BFA. IMPLICATIONS FOR CANCER SURVIVORS: These findings 
   support the clinical utility of acupuncture as an evidence-based option for 
   managing fatigue in cancer survivors with pain. TRIAL REGISTRATION: 
   ClinicalTrials.gov Identifier: NCT02979574; November 30, 2016.
C1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Rehabilitation Medicine, Singapore General Hospital, Singapore, Singapore.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Weill Cornell Medical College, Cornell University, New York, NY, USA.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. maoj@mskcc.org.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD DEC 13
PY 2025
VL 34
IS 1
BP 31
EP 31
DI 10.1007/s00520-025-10219-z 
PG 0
WC Humans; Fatigue; therapy; Female; Middle Aged; Male; Chronic Pain; therapy; Cancer Survivors; Acupuncture Therapy; methods; Aged; Neoplasms; complications; Electroacupuncture; methods; Severity of Illness Index
UT PubMed:41389238
PM 41389238
DA 2025-12-13
ER

PT J
AU Bao, T
   Seidman, AD
   Piulson, L
   Vertosick, E
   Chen, X
   Vickers, AJ
   Blinder, VS
   Zhi, WI
   Li, Q
   Vahdat, LT
   Dickler, MN
   Robson, ME
   Mao, JJ
AF Bao, Ting
   Seidman, Andrew D
   Piulson, Lauren
   Vertosick, Emily
   Chen, Xi
   Vickers, Andrew J
   Blinder, Victoria S
   Zhi, Wanqing I
   Li, Qing
   Vahdat, Linda T
   Dickler, Maura N
   Robson, Mark E
   Mao, Jun J
TI A phase IIA trial of acupuncture to reduce chemotherapy-induced peripheral 
SO European journal of cancer (Oxford, England : 1990)
LA English
DT Journal Article
DE Acupuncture; Breast cancer; CIPN; Chemotherapy; Chemotherapy-induced peripheral neuropathy; Paclitaxel
AB PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and 
   potentially dose-limiting side-effect of neurotoxic chemotherapy for cancer 
   patients. We evaluated the preliminary efficacy of acupuncture in preventing 
   worsening CIPN in patients receiving paclitaxel. METHODS: In this phase IIA 
   single-arm clinical trial, we screened stage I-III breast cancer patients 
   receiving neoadjuvant/adjuvant weekly paclitaxel for development of CIPN. The 
   primary objective was to assess acupuncture's efficacy in preventing the 
   escalation of National Cancer Institute-Common Toxicity Criteria for Adverse 
   Events (NCI-CTCAE), version 4.0, grade II CIPN to higher grades. Acupuncture was 
   deemed worthy of further study if 23 or more of the 27 enrolled patients did not 
   develop grade III CIPN. Outcome measures (NCI-CTCAE CIPN grade, Functional 
   Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity 
   [FACT/GOG-Ntx], Neuropathic Pain Scale [NPS]) were obtained weekly during the 
   intervention. RESULTS: Of 104 patients screened, 37 developed grade II CIPN 
   (36%), and 28 (27%) enrolled into the intervention phase; one was removed due to 
   protocol violation. Of the 27 patients receiving acupuncture, 26 completed 
   paclitaxel treatment without developing grade III CIPN, meeting our prespecified 
   success criteria for declaring acupuncture worthy of further study. FACT/GOG-Ntx 
   and NPS scores remained stable during the intervention while continuing weekly 
   paclitaxel. Acupuncture treatment was well tolerated; 4 of 27 (15%) patients 
   reported grade I bruising. CONCLUSIONS: Acupuncture was safe and showed 
   preliminary evidence of effectiveness in reducing the incidence of high grade 
   CIPN during chemotherapy. A follow-up randomised controlled trial is needed to 
   establish definitive efficacy in CIPN prevention for patients at risk.
C1 Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA. 
   Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065, USA. 
   Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA. 
   Memorial Sloan Kettering Cancer Center, 485 Lexington Avenue, New York, NY, 10017, USA. 
   Memorial Sloan Kettering Cancer Center, 444 E 68th Street, New York, NY, 10065, USA. 
   Memorial Sloan Kettering Cancer Center, 485 Lexington Avenue, New York, NY, 10017, USA. 
   Memorial Sloan Kettering Cancer Center, 485 Lexington Avenue, New York, NY, 10017, USA. 
   Memorial Sloan Kettering Cancer Center Commack, 650 Commack Road, Commack, NY, 11725, USA. 
   Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA. 
   Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065, USA. 
   Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065, USA. 
   Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065, USA. 
   Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA. 
EM maoj@mskcc.org
NR 0
TC 0
SN 1879-085
EI 0959-804
J9 Eur J Cancer
PD JUL 17
PY 2018
VL 101
IS 
BP 12
EP 19
DI 10.1016/j.ejca.2018.06.008 
PG 7
WC Acupuncture Therapy; adverse effects; Adult; Antineoplastic Combined Chemotherapy Protocols; adverse effects; Breast Neoplasms; drug therapy; Chemotherapy, Adjuvant; Contusions; etiology; Female; Humans; Middle Aged; Neoadjuvant Therapy; Paclitaxel; administration & dosage; Peripheral Nervous System Diseases; chemically induced; Severity of Illness Index; Treatment Outcome
UT PubMed:30007894
PM 30007894
DA 2018-07-17
ER

PT J
AU Wang, YH
   Zhou, MF
   Chen, L
   Song, YF
   Sun, MZ
   Pei, LX
   Sun, JH
AF Wang, Yu-Hang
   Zhou, Ming-Fei
   Chen, Lu
   Song, Ya-Fang
   Sun, Meng-Zhu
   Pei, Li-Xia
   Sun, Jian-Hua
TI [Application of Tiaoshen Jianpi acupuncture and moxibustion in hospice care for 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE Tiaoshen Jianpi; acupuncture and moxibustion; analgesia; cancer, terminal; hospice care
AB To analyze the application feasibility of Tiaoshen Jianpi acupuncture and 
   moxibustion in hospice care for terminal cancer patients. Tiaoshen Jianpi 
   acupuncture and moxibustion adjusts the spirit to regulate emotions and fortifies 
   the spleen to supplement and boost foundation of acquired (postnatal) 
   constitution. And it could relieve adverse reactions after radiotherapy and 
   chemotherapy, alleviate pain and regulate emotions in hospice care for terminal 
   cancer patients, so as to promote the progress of hospice care for terminal 
   cancer patients.
C1 School of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.
   Department of Oncology, Nanjing Xiaohang Hospital.
   Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province.
   School of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.
   School of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.
   Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province.
   Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAR 11
PY 2022
VL 42
IS 3
BP 333
EP 6
DI 10.13703/j.0255-2930.20201210-k0002 
PG -327
WC Acupuncture Therapy; Hospice Care; Humans; Moxibustion; Neoplasms; therapy; Spleen
UT PubMed:35272415
PM 35272415
DA 2022-03-11
ER

PT J
AU Tao, SY
   Tang, J
   Wang, X
   Jiang, NN
   Li, Y
   Wu, P
AF Tao, Si-Yu
   Tang, Jie
   Wang, Xue
   Jiang, Nan-Nan
   Li, Yuan
   Wu, Ping
TI Moxibustion as an adjunctive treatment for rheumatoid arthritis and its effects 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE Wnt/β-catenin signaling pathway; bone metabolism; moxibustion; rheumatoid arthritis (RA); sclerostin (SOST); tumor necrosis factor-α (TNF-α); β-catenin
AB OBJECTIVES: To observe the clinical efficacy of moxibustion as an adjunctive 
   treatment for rheumatoid arthritis (RA) based on conventional medication and its 
   effects on serum sclerostin (SOST) and β-catenin levels, exploring the potential 
   mechanisms by which moxibustion may protect joint bones in RA patients. METHODS: 
   Seventy-six RA patients were randomly divided into an observation group (38 
   cases, 3 cases dropped out) and a control group (38 cases, 4 cases were 
   eliminated, 2 cases dropped out). The patients in the control group were treated 
   with conventional oral medication; based on the treatment of the control group, 
   the patients in the observation group were treated with moxibustion. The direct 
   moxibustion was applied at Zusanli (ST 36) on both sides and ashi points around 
   small joints, and indirect moxibustion was applied at Shenshu (BL 23) on both 
   sides and ashi points around large joints. The treatment was given three times a 
   week for a total of 5 weeks. The count of pain and swollen joint, morning 
   stiffness score, disease activity score of 28 joints (DAS28), visual analogue 
   scale (VAS) score, health assessment questionnaire (HAQ) score, and serum levels 
   of SOST, β-catenin, and tumor necrosis factor-α (TNF-α) were evaluated before and 
   after treatment in the two groups. RESULTS: Compared those before treatment, 
   after treatment, both groups showed a reduction in pain and swollen joint count 
   (P<0.01, P<0.05), morning stiffness, DAS28, VAS, and HAQ scores (P<0.01, P<0.05), 
   with the observation group having lower scores than the control group (P<0.01). 
   Serum levels of SOST, β-catenin, and TNF-α after treatment in the observation 
   group were lower than those in both before treatment and the control group 
   (P<0.01, P<0.05). There was a positive correlation between the difference in 
   serum β-catenin levels before and after treatment and the difference in serum 
   SOST (r=0.578, P<0.001) and TNF-α (r=0.403, P<0.05) levels in the observation 
   group. CONCLUSIONS: In addition to medication, moxibustion as an adjunctive 
   treatment could significantly alleviate joint pain and reduce disease activity in 
   RA patients, suggesting a potential role in joint protection. This mechanism may 
   be related to the inhibition of the inflammatory factor TNF-α, regulation of 
   β-catenin levels, and reduction in the production of the endogenous negative 
   regulator protein SOST within the Wnt/β-catenin signaling pathway.
C1 College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China. 269402733@qq.com.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   Department of Rheumatic Immunology, Hospital of Chengdu University of TCM/TCM Hospital of Sichuan Province.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China. wuping_33@163.com.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD DEC 14
PY 2023
VL 43
IS 12
BP 1384
EP 1389
DI 10.13703/j.0255-2930.20230414-k0005 
PG 5
WC Humans; Moxibustion; Tumor Necrosis Factor-alpha; beta Catenin; Acupuncture Points; Arthritis, Rheumatoid; therapy; Arthralgia; Adaptor Proteins, Signal Transducing
UT PubMed:38092536
PM 38092536
DA 2023-12-14
ER

PT J
AU Liu, X
   Lu, J
   Wang, G
   Chen, X
   Xv, H
   Huang, J
   Xue, M
   Tang, J
AF Liu, Xiaomeng
   Lu, Jing
   Wang, Guoxin
   Chen, Xiu
   Xv, Haiping
   Huang, Jing
   Xue, Mingxin
   Tang, Jinhai
TI Acupuncture for Arthralgia Induced by Aromatase Inhibitors in Patients with 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; aromatase inhibitor-induced arthralgia; breast cancer; meta-analysis
AB BACKGROUND: Aromatase inhibitor-induced arthralgia (AIA) is the most common side 
   effect of aromatase inhibitors (AIs) used in breast cancer patients and is 
   related to the rate of adherence to AIs. The clinical effects of acupuncture on 
   AIA have been assessed by some randomized controlled trials (RCTs). However, some 
   studies reported that acupuncture was effective, while others claimed that it was 
   ineffective. To clarify the clinical and placebo effects of acupuncture in 
   treating AIA, we conducted this meta-analysis. METHODS: Two reviewers (XL and GW) 
   independently searched for RCTs in 5 English databases (PubMed, Web of Science, 
   Embase, Springer, Cochrane Library) and 4 Chinese databases (China National 
   Knowledge Infrastructure Database (CNKI), SinoMed, VIP and Wanfang Database) from 
   their inception to 30 November 2019. Following the Preferred Reporting Items for 
   Systematic Reviews and Meta-Analyses (PRISMA) guidelines, this meta-analysis was 
   performed by fixed or random-effects models, and data were pooled with mean 
   differences (MDs). RESULTS: Seven trials involving 603 patients were reviewed. 
   The primary outcome, the Brief Pain Inventory (BPI) score, significantly differed 
   between the acupuncture and control groups [pain-related interference: 
   MD = -1.89, 95% confidence interval (CI) [-2.99, -0.79], Z = 3.36 
   (P = .008 < .05), pain severity: MD = -1.57, 95% CI [-2.46, -0.68], Z = 3.45 
   (P = .0006 < .05), worst pain: MD = -2.31, 95% CI [-3.15, -1.48], Z = 5.47 
   (P < .0001 < .05)]. No severe adverse events were reported in any study. 
   CONCLUSION: This meta-analysis showed that acupuncture is a safe and effective 
   treatment for breast cancer patients with AIA. Additional research with improved 
   blinding methods is warranted to further explore the nature of non-specific and 
   placebo effects in true and sham acupuncture.
C1 Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
   The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's 
   The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
   Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
   The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
   The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
   Third Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
   Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
   The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's 
   The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD FEB 16
PY 2021
VL 20
IS 
BP 1534735420980811
EP 1534735420980811
DI 10.1177/1534735420980811 
PG 1
WC Acupuncture Therapy; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Female; Humans; Treatment Outcome
UT PubMed:33586504
PM 33586504
DA 2021-02-16
ER

PT J
AU Tao, W
   Luo, X
   Cui, B
   Liang, D
   Wang, C
   Duan, Y
   Li, X
   Zhou, S
   Zhao, M
   Li, Y
   He, Y
   Wang, S
   Kelley, KW
   Jiang, P
   Liu, Q
AF Tao, Weiwei
   Luo, Xi
   Cui, Bai
   Liang, Dapeng
   Wang, Chunli
   Duan, Yangyang
   Li, Xiaofen
   Zhou, Shiyu
   Zhao, Mingjie
   Li, Yi
   He, Yumin
   Wang, Shaowu
   Kelley, Keith W
   Jiang, Ping
   Liu, Quentin
TI Practice of traditional Chinese medicine for psycho-behavioral intervention 
SO Oncotarget
LA English
DT Journal Article
DE cancer; meta-analysis; psycho-behavioral interventions; quality of life; traditional Chinese medicine
AB BACKGROUND: Cancer patients suffer from diverse symptoms, including depression, 
   anxiety, pain, and fatigue and lower quality of life (QoL) during disease 
   progression. This study aimed to evaluate the benefits of Traditional Chinese 
   Medicine psycho-behavioral interventions (TCM PBIs) on improving QoL by 
   meta-analysis. RESULTS: The six TCM PBIs analyzed were acupuncture, Chinese 
   massage, Traditional Chinese Medicine five elements musical intervention (TCM 
   FEMI), Traditional Chinese Medicine dietary supplement (TCM DS), Qigong and Tai 
   Chi. Although both TCM PBIs and non-TCM PBIs reduced functional impairments in 
   cancer patients and led to pain relief, depression remission, reduced time to 
   flatulence following surgery and sleep improvement, TCM PBIs showed more 
   beneficial effects as assessed by reducing both fatigue and gastrointestinal 
   distress. In particular, acupuncture relieved fatigue, reduced diarrhea and 
   decreased time to flatulence after surgery in cancer patients, while therapeutic 
   Chinese massage reduced time to flatulence and time to peristaltic sound. 
   METHODS: Electronic literature databases (PubMed, CNKI, VIP, and Wanfang) were 
   searched for randomized, controlled trials conducted in China. The primary 
   intervention was TCM PBIs. The main outcome was health-related QoL (HR QoL) 
   post-treatment. We applied standard meta analytic techniques to analyze data from 
   papers that reached acceptable criteria. CONCLUSION: These findings demonstrate 
   the efficacy of TCM PBIs in improving QoL in cancer patients and establish that 
   TCM PBIs represent beneficial adjunctive therapies for cancer patients.
C1 Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
   Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South 
   College of Nursing, Dalian Medical University, Dalian, China.
   Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
   Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South 
   Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
   Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South 
   Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
   Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South 
   Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
   Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South 
   Department of Radiology, Second Affiliated Hospital, Dalian Medical University, Dalian, China.
   School of Public Health, Dalian Medical University, Dalian, China.
   Department of Psychology, Dalian Medical University, Dalian, China.
   Dalian Medical University Magazine, Dalian, China.
   School of Art, Dalian Medical University, Dalian, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Department of Radiology, Second Affiliated Hospital, Dalian Medical University, Dalian, China.
   Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, Urbana, IL, USA.
   Department of Pathology, College of Medicine, University of Illinois at 
   Graduate School, Dalian Medical University, Dalian, China.
   Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.
   Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South 
NR 0
TC 0
SN 1949-255
EI 
J9 Oncotarget
PD OCT 27
PY 2015
VL 6
IS 37
BP 39725
EP 39
DI 10.18632/oncotarget.5388 
PG -39686
WC Acupuncture Therapy; methods; Behavior Therapy; methods; Clinical Trials as Topic; Diet Therapy; methods; Fatigue; therapy; Female; Gastrointestinal Diseases; therapy; Humans; Male; Massage; methods; Medicine, Chinese Traditional; methods; Middle Aged; Neoplasms; physiopathology; Outcome Assessment, Health Care; methods; Pain; physiopathology; Psychotherapy; methods; Qigong; Quality of Life; Tai Ji
UT PubMed:26498685
PM 26498685
DA 2015-10-27
ER

PT J
AU Lu, Z
   Wang, Q
   Sun, X
   Zhang, W
   Min, S
   Zhang, J
   Zhao, W
   Jiang, J
   Wang, Y
   Zhu, Y
   Zheng, L
   Wang, Y
   Guo, Y
   Zhang, L
   Wang, L
   Lei, C
   Liu, T
   Yang, X
   Zhang, J
   Li, C
   Zhang, N
   Dong, H
   Xiong, L
AF Lu, Zhihong
   Wang, Qiang
   Sun, Xude
   Zhang, Wei
   Min, Su
   Zhang, Jiaqiang
   Zhao, Weixian
   Jiang, Jianfeng
   Wang, Yonghui
   Zhu, Yaomin
   Zheng, Lanlan
   Wang, Ying
   Guo, Yuanyuan
   Zhang, Liyuan
   Wang, Lini
   Lei, Chong
   Liu, Tingting
   Yang, Xue
   Zhang, Junbao
   Li, Chen
   Zhang, Nian
   Dong, Hailong
   Xiong, Lize
TI Transcutaneous electrical acupoint stimulation before surgery reduces chronic 
SO Journal of clinical anesthesia
LA English
DT Journal Article
DE Acupoint stimulation; Chronic pain; Combined acupoints; Mastectomy; Postoperative pain
AB STUDY OBJECTIVE: Despite multiple interventions, the incidence of chronic pain 
   after mastectomy could be as high as 50% after surgery. This study aimed to 
   determine the efficacy of transcutaneous electrical acupoint stimulation (TEAS) 
   before anesthesia induction in reducing chronic pain and to compare the effect of 
   combined acupoint TEAS with that of single acupoint TEAS. DESIGN: A multicenter 
   randomized clinical trial. SETTING: The study was conducted at six medical 
   centers in China from May 2016 to April 2018. Final follow-up was on October 26, 
   2018. PARTICIPANTS: Eligible patients were women scheduled for radical mastectomy 
   under general anesthesia. INTERVENTIONS: Patients were randomly and equally 
   grouped into sham control (n = 188), single acupoint (PC6, n = 198), or combined 
   acupoints (PC6 and CV17, n = 190) TEAS groups using a centralized 
   computer-generated randomization system. TEAS was applied for 30 min before 
   anesthesia induction. The sham-operated control group received electrode 
   attachment but without stimulation. Anesthesiologists, surgeons, and outcome 
   assessors were blinded to the interventions. MEASURES: The primary endpoint was 
   the incidence of chronic pain 6 months after surgery. Incidences were compared 
   among the groups using the unadjusted χ(2) test. RESULTS: Of the 576 randomized 
   patients, 568 completed the trial. In the intention-to-treat analysis, 
   post-mastectomy pain at 6 months was reported in 42 of 190 patients (22.1%) in 
   the combined acupoints group, 65 of 188 patients (34.6%) in the sham-operated 
   group (P = 0.007; relative risk [RR], 95% confidence interval [CI]: 0.68, 
   0.52-0.89), and 72 of 198 patients (36.4%) in the single acupoint group 
   (P = 0.002; RR, 95% CI: 0.72, 0.55-0.93). Remifentanil consumption during surgery 
   and postoperative nausea and vomiting at 24 h after surgery were lower in the 
   combined acupoint group than that in the sham-operated group. CONCLUSION: TEAS at 
   combined acupoints before surgery was associated with reduced chronic pain 
   6 months after surgery. TRIAL REGISTRATION: Clinicaltrials.gov identifier: 
   NCT02741726. Registered on April 13, 2016.
C1 Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. 
   Department of Anesthesiology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
   Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, China.
   Department of Anesthesiology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China.
   Department of Anesthesiology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
   Department of Anesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.
   Department of Anesthesiology, Second Affiliated Hospital of Guangdong University of Traditional Chinese Medicine, Guangzhou, Guangdong 510120, China.
   Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
   Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
   Department of Anesthesiology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
   Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, China.
   Department of Anesthesiology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China.
   Department of Anesthesiology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
   Department of Anesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.
   Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
   Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
   Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
   Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
   Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
   Department of Medical Statistics, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
   Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, China.
   Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
   Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China
   Department ofAnesthesiology and Perioperative Medicine, Translational Research Institute ofBrain and Brain-Like Intelligence， Shanghai Fourth People's Hospital Affiliatedto Tongji University School of Medicine, Shanghai 200434, China. Electronicaddress: lizexiong@tongji.edu.cn.
EM eerlu23@163.com
NR 0
TC 0
SN 1873-452
EI 
J9 J Clin Anesth
PD JUL 17
PY 2021
VL 74
IS 
BP 110453
EP 110453
DI 10.1016/j.jclinane.2021.110453 
PG 0
WC Acupuncture Points; Anesthesia, General; adverse effects; Breast Neoplasms; surgery; Chronic Pain; epidemiology; Female; Humans; Mastectomy; adverse effects
UT PubMed:34271271
PM 34271271
DA 2021-07-17
ER

PT J
AU Bettini, E
   Idiokitas, R
   Mahmood, L
   Jacobs, S
   Steinhorn, D
AF Bettini, Elizabeth
   Idiokitas, Risi
   Mahmood, Laila
   Jacobs, Shana
   Steinhorn, David
TI Safety and Acceptance of Acupuncture and Acupressure in Children, Adolescents, 
SO Cancer nursing
LA English
DT Journal Article
AB BACKGROUND: Hematopoietic stem cell transplant (HSCT) is associated with 
   significant morbidity and high symptom burden including mucositis pain, nausea, 
   and vomiting. There is little documentation in the literature regarding 
   acupuncture or acupressure for children undergoing HSCT. OBJECTIVE: The purpose 
   of this study was to determine the safety and acceptance of acupuncture and 
   acupressure in children undergoing HSCT in a large tertiary care children's 
   hospital. METHODS: This is a descriptive retrospective study that evaluated 80 
   admissions to the HSCT unit over a 24-month period. Every child admitted for HSCT 
   was offered acupuncture or acupressure as part of their care. RESULTS: Of 80 
   patients, 46 were male patients (ages range, 0-32 years; mean, 8 years). 
   Diagnoses include leukemia/lymphoma, sickle cell disease, aplastic anemia, 
   neuroblastoma, and other metabolic, other solid tumor, or other hematologic 
   disorders. Both allogenic and autologous were represented. Sixty-six patients 
   (82.5%) agreed to treatment with acupuncture, acupressure, or both. There were no 
   adverse effects or safety concerns noted. Symptoms addressed by acupuncture or 
   acupressure included pain from mucositis, nausea, constipation, diarrhea, 
   anxiety, insomnia, and general wellness or healing. CONCLUSION: This study 
   demonstrates that acupuncture and acupressure are well accepted by children and 
   their families admitted for HSCT and are safe even when performed in the first 4 
   weeks following transplant when the patient is likely to have thrombocytopenia. 
   IMPLICATIONS FOR PRACTICE: These findings suggest that there may be more 
   therapies for patients undergoing HSCT to help with symptom control.
C1 Author Affiliations: Palliative Care, Children's National Hospital, Washington, DC (Drs Bettini, Idiokitas, Mahmood, and Jacobs)
   and Capital Caring Hospice,Falls Church, Virginia (Dr Steinhorn).
NR 0
TC 0
SN 1538-980
EI 
J9 Cancer Nurs
PD JUN 10
PY 2022
VL 46
IS 3
BP E204
EP E207
DI 10.1097/NCC.0000000000001135 
PG 1
WC Humans; Child; Male; Adolescent; Young Adult; Infant, Newborn; Infant; Child, Preschool; Adult; Female; Acupressure; Mucositis; etiology; Retrospective Studies; Acupuncture Therapy; adverse effects; Nausea; etiology; Pain; etiology; Hematopoietic Stem Cell Transplantation; adverse effects
UT PubMed:35679148
PM 35679148
DA 2022-06-10
ER

PT J
AU Lee, I
   Garland, SN
   DeMichele, A
   Farrar, JT
   Im, EO
   Mao, JJ
AF Lee, Iris
   Garland, Sheila N
   DeMichele, Angela
   Farrar, John T
   Im, Eun-Ok
   Mao, Jun J
TI A cross-sectional survey of pain catastrophising and acupuncture use among breast 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE ACUPUNCTURE; ONCOLOGY; PAIN MANAGEMENT
AB INTRODUCTION: Treatment-related joint pain affects almost half of all women with 
   breast cancer using aromatase inhibitors and is a major reason for terminating 
   treatment. Although acupuncture is becoming an increasingly popular, 
   evidence-based option for treating pain, little is known about the potential 
   influence of psychological factors on acupuncture use. OBJECTIVE: We aimed to 
   evaluate the association between pain catastrophising and use of acupuncture in 
   breast cancer survivors experiencing arthralgia. METHODS: We conducted a 
   cross-sectional survey of arthralgic breast cancer patients. Patients were asked 
   if they had used acupuncture since their cancer diagnosis. The Pain 
   Catastrophising Scale (PCS) was used to measure negative coping styles related to 
   the experience of pain. We performed multiple logistic regression analysis to 
   evaluate the relationship between pain catastrophising and acupuncture use, 
   adjusting for covariates. RESULTS: Of the 424 participants, 69 (16%) reported use 
   of acupuncture since their breast cancer diagnosis. In multivariate analyses, 
   compared to those in the lowest PCS score tertile, patients with the highest PCS 
   scores were more likely to have used acupuncture (p=0.03). In particular, 
   patients with high levels of rumination (p=0.005) and magnification (p=0.008) 
   were more likely to have used acupuncture. Helplessness was not associated with 
   acupuncture use (p=0.23). CONCLUSIONS: High levels of pain catastrophising, and 
   specifically the processes of rumination and magnification, were associated with 
   greater acupuncture use. We believe this could have important implications for 
   understanding which population is more likely to seek acupuncture treatment and 
   how this alternative therapy could be better targeted to these patients.
C1 Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
   Department of Biostatistics and Epidemiology, Perelman School of Medicine at the 
   Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
   Department of Psychology, Memorial University of Newfoundland, St John's, 
   Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
   Abramson Cancer Center, Perelman School of Medicine at the University of 
   Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
   Abramson Cancer Center, Perelman School of Medicine at the University of 
   Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
   School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
   Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
   Department of Biostatistics and Epidemiology, Perelman School of Medicine at the 
   Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
   The Bendheim Center for Integrative Medicine, Memorial Sloan-Kettering Cancer 
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD MAY 15
PY 2016
VL 35
IS 1
BP 38
EP 43
DI 10.1136/acupmed-2016-011056 
PG 5
WC Acupuncture Therapy; methods; Aged; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Catastrophization; chemically induced; Cross-Sectional Studies; Female; Humans; Middle Aged; Pain Measurement; Surveys and Questionnaires; Survivors; psychology; Treatment Outcome
UT PubMed:27177930
PM 27177930
DA 2016-05-15
ER

PT J
AU Huang, XR
   Xu, M
   Xu, Y
   Wang, SJ
   Ni, FL
AF Huang, Xin-Rui
   Xu, Min
   Xu, Yan
   Wang, Shu-Jie
   Ni, Fei-Lin
TI Auricular acupressure for insomnia in women with breast cancer: A systematic 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Breast cancer as the malignant tumor with the highest incidence and 
   mortality rate among the global female population. Insomnia is a common complaint 
   in breast cancer patients, more than one-third (38-47%) of breast cancer patients 
   suffer it. Auricular acupressure (AA), a non-pharmacological therapy, has been 
   used in the studies to intervene in insomnia in breast cancer patients. The 
   objective of this systematic review and meta-analysis is to investigate the 
   efficacy and safety of AA therapy in intervening with insomnia in breast cancer. 
   METHODS: A systematic literature search was performed for 10 databases up to 
   January of 2024 to identify randomized control trials (RCTs). The methodological 
   quality of RCTs was assessed independently using the Cochrane Handbook for 
   Systematic Reviews of Interventions. The quality of evidence was evaluated with 
   the Grading of Recommendations Assessment, Development and Evaluation approach. 
   Data were screened and extracted independently using predesigned forms. The 
   meta-analysis was conducted using RevMan 5.3 software, P-value < .05 means 
   statistically significant. RESULTS: This review included 15 studies from 3 
   different countries with a total of 1125 adult participants. The pooled results 
   showed that AA significantly in improving sleep quality (mean difference 
   [MD] = -3.36, 95% confidence interval [CI]: [-4.65, -2.07], P < .001) and life 
   quality (MD = -7.82, 95% CI: [-14.76, -0.88], P = .03). Based on data from sleep 
   monitoring devices, AA was valuable for improving sleep efficiency (MD = -3.63, 
   95% CI: [-4.19,-3.07], P = .03) in breast cancer patients. Adverse events were 
   reported in 5 RCTs. Common adverse reactions include auricular skin allergic 
   reaction (10/259, 3.9%), bruising (7/259, 2.7%), pain (3/259, 1.2%), and local 
   pressure ulcers on the auricular points (2/259, 0.8%). The evidence grade was 
   moderate because of the substantial heterogeneity among studies. Heart, Shenmen, 
   and Subcortex were the 3 most numerous auricular points, with a total share of up 
   to 71.70%. CONCLUSION: This systematic review and meta-analysis demonstrates the 
   efficacy and safety of AA in intervening insomnia in breast cancer patients, 
   providing a basis for the selection of clinical auricular points. However, the 
   high-quality RCTs in existence are not enough, and more rigorous trials are 
   needed to identify the efficacy of AA and insomnia.
C1 Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou,Zhejiang Province, China.
   Office of the Dean, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ZhejiangProvince, China.
   College of Nursing, Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang Province, China.
   Department of Breast Diseases, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou,Zhejiang Province, China.
   Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou,Zhejiang Province, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD FEB 17
PY 2025
VL 104
IS 7
BP e41498
EP e41498
DI 10.1097/MD.0000000000041498 
PG 1
WC Humans; Female; Sleep Initiation and Maintenance Disorders; therapy; Breast Neoplasms; complications; Acupressure; methods; Randomized Controlled Trials as Topic; Acupuncture, Ear; methods
UT PubMed:39960920
PM 39960920
DA 2025-02-17
ER

PT J
AU Bao, T
   Li, SQ
   Dearing, JL
   Piulson, LA
   Seluzicki, CM
   Sidlow, R
   Mao, JJ
AF Bao, Ting
   Li, Susan Q
   Dearing, Josh L
   Piulson, Lauren A
   Seluzicki, Christina M
   Sidlow, Robert
   Mao, Jun J
TI Acupuncture versus medication for pain management: a cross-sectional study of 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE acupuncture; complementary medicine; oncology; pain management
AB AIM OF THE STUDY: Breast cancer survivors who take aromatase inhibitors (AI) 
   often suffer from chronic pain. Emerging evidence supports the use of acupuncture 
   as an effective pain management strategy for this condition, but its 
   acceptability among cancer survivors is unknown. We evaluated breast cancer 
   survivors' preferences for acupuncture as compared with medication use and 
   identified factors predictive of this preference. METHODS: We conducted a 
   cross-sectional study among breast cancer survivors who were currently, or had 
   been, taking an AI. The primary outcome was degree of preference for acupuncture 
   as compared with medication for pain management. We conducted multivariate 
   logistic regression analyses to evaluate the effects of socioeconomic status 
   (SES) factors and health beliefs on treatment preference. RESULTS: Among 592 
   participants, 160 (27.0%) preferred acupuncture, 153 (25.8%) preferred medication 
   and 279 (47.1%) had no clear preference. In a multivariate analysis that only 
   included SES, higher education and white race were significantly associated with 
   greater preference for acupuncture. When health beliefs were added, SES effects 
   were attenuated, while greater expectation of acupuncture's effect, lower 
   perceived barriers to its use, higher social norm (endorsement from family 
   members and healthcare professionals) related to acupuncture and higher holistic 
   health beliefs were associated with greater preference for acupuncture. 
   CONCLUSION: We found similar rates of preference for acupuncture versus 
   medication among breast cancer survivors for pain management. Specific attitudes 
   and beliefs predicted such preferences, highlighting the importance of a 
   patient-centred approach to align patient beliefs and preferences with 
   therapeutic options for more effective pain management. TRIAL REGISTRATION 
   NUMBER: NCT01013337; Results.
C1 Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA.
   Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA.
   Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA.
   Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA.
   Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA.
   Division of Survivorship and Supportive Care, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA.
NR 0
TC 0
SN 1759-987
EI 0964-528
J9 Acupunct Med
PD FEB 15
PY 2018
VL 36
IS 2
BP 80
EP 87
DI 10.1136/acupmed-2017-011435 
PG 7
WC Acupuncture Therapy; Adult; Aged; Aged, 80 and over; Aromatase Inhibitors; therapeutic use; Breast Neoplasms; complications; Cancer Survivors; psychology; Chronic Pain; drug therapy; Cross-Sectional Studies; Culture; Female; Humans; Longitudinal Studies; Middle Aged; Pain; drug therapy; Patient Preference; Prospective Studies
UT PubMed:29440043
PM 29440043
DA 2018-02-15
ER

PT J
AU Choi, H
   Gao, S
   Schlaeger, JM
   Patil, CL
   Doorenbos, AZ
   Sullivan, K
   Lif, N
   Li, H
AF Choi, Hannah
   Gao, Shuang
   Schlaeger, Judith M
   Patil, Crystal L
   Doorenbos, Ardith Z
   Sullivan, Katelyn
   Lif, Natalie
   Li, Hongjin
TI Expectancy Effect of Acupuncture on Cancer-Related Outcomes: A Systematic Review.
SO Oncology nursing forum
LA English
DT Journal Article
DE acupuncture; cancer; expectancy; symptom; systematic review
AB PROBLEM IDENTIFICATION: Previous reviews have reported the efficacy of 
   acupuncture in managing cancer-related symptoms. However, there is a lack of 
   comprehensive reviews examining how patients' expectancy regarding acupuncture 
   influences treatment outcomes in the context of cancer survivorship. LITERATURE 
   SEARCH: 9 databases were searched for articles published through August 2023. The 
   authors included acupuncture studies that reported on patient expectancy for the 
   effectiveness of acupuncture. DATA EVALUATION: 10 studies were included in this 
   review. Study quality was assessed using the Cochrane risk-of-bias tool and the 
   ROBINS-I (Risk Of Bias In Non-randomised Studies-of Interventions) tool. 
   SYNTHESIS: 5 studies explored the relationship between expectancy and 
   cancer-related outcomes, and in 3, expectancy was significantly associated with 
   reduced pain, frequency of bowel movements, and severity of insomnia. Male and 
   older patients, nonresponders to acupuncture, and those with lower education 
   levels had lower expectancy regarding acupuncture. IMPLICATIONS FOR NURSING: 
   Healthcare providers should assess patient expectancy to comprehensively 
   understand its role in improving acupuncture outcomes.
C1 University of Illinois.
   University of Illinois.
   University of Illinois.
   University of Illinois, Chicago.
   University of Illinois at Chicago.
   University of Illinois.
   University of Illinois.
   University of Illinois at Chicago.
NR 0
TC 0
SN 1538-068
EI 
J9 Oncol Nurs Forum
PD OCT 21
PY 2024
VL 51
IS 6
BP 547
EP 564
DI 10.1188/24.ONF.547-564 
PG 17
WC Humans; Acupuncture Therapy; methods; Neoplasms; complications; Male; Female; Middle Aged; Aged; Adult; Aged, 80 and over; Treatment Outcome
UT PubMed:39431691
PM 39431691
DA 2024-10-21
ER

PT J
AU Zhi, WI
   Ingram, E
   Li, SQ
   Chen, P
   Piulson, L
   Bao, T
AF Zhi, W Iris
   Ingram, Evan
   Li, Susan Qing
   Chen, Patricia
   Piulson, Lauren
   Bao, Ting
TI Acupuncture for Bortezomib-Induced Peripheral Neuropathy: Not Just for Pain.
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; bortezomib; multiple myeloma; peripheral neuropathy
AB BACKGROUND: Bortezomib-induced peripheral neuropathy (BIPN) is a common and 
   debilitating side effect. Our pilot study demonstrated that acupuncture is safe 
   and can decrease total neuropathic symptoms. However, there is lack of knowledge 
   in which individual BIPN symptoms benefited from acupuncture. PURPOSE: To 
   characterize individual symptoms reduced by acupuncture in patients with BIPN. 
   METHODS: Patients with multiple myeloma treated with bortezomib who developed 
   BIPN grade 2 or above, based on National Cancer Institute Common Terminology 
   Criteria for Adverse Events (NCI CTCAE), were enrolled and received 10 
   acupuncture treatments over 10 weeks. Self-reported BIPN-associated symptoms 
   assessments were collected weekly at baseline, during, and after acupuncture 
   treatment using the Neuropathy Pain Scale (NPS) and the Functional Assessment of 
   Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) 
   questionnaires. Changes in individual symptoms were analyzed based on 
   FACT/GOG-Ntx and NPS scores. RESULTS: There were statistically significant 
   reductions in individual symptoms in both NPS and FACT/GOG-Ntx. The FACT/GOG-Ntx 
   reductions were most pronounced in hand/feet numbness/tingling, discomfort, and 
   trouble walking. The sensory symptoms, such as tingling and numbness, especially 
   in the feet, reduced the most ( P < .0001), and motor dysfunction also reduced 
   significantly ( P = .0001). Both hearing and dysfunction scores were also 
   statistically significantly increased, indicating improved symptoms. The NPS 
   scores showed significant symptom relief in all 10 items from the NPS assessment, 
   particularly in cold sensitivity and an unpleasant feeling. CONCLUSIONS: 
   Acupuncture can improve multiple symptoms associated with BIPN, particularly 
   numbness and tingling in hands and feet, cold sensitivity, and an unpleasant 
   feeling. Further randomized control trials are warranted to confirm our findings.
C1 1 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   2 University of Toledo, Toledo, OH, USA.
   1 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   1 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   1 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   1 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD JUL 22
PY 2018
VL 17
IS 4
BP 1079
EP 1086
DI 10.1177/1534735418788667 
PG 7
WC Acupuncture; methods; Acupuncture Therapy; methods; Aged; Bortezomib; adverse effects; Female; Humans; Male; Middle Aged; Multiple Myeloma; drug therapy; Pain; physiopathology; Pain Measurement; methods; Peripheral Nervous System Diseases; chemically induced; Pilot Projects
UT PubMed:30027756
PM 30027756
DA 2018-07-22
ER

PT J
AU Thottungal, A
   Kumar, P
   Bhaskar, A
AF Thottungal, Athmaja
   Kumar, Pranab
   Bhaskar, Arun
TI Interventions for myofascial pain syndrome in cancer pain: recent advances: why, 
SO Current opinion in supportive and palliative care
LA English
DT Review
AB PURPOSE OF REVIEW: Pain is one of the most feared and most common symptoms of 
   cancer, experienced by 38-85% of patients. Pain in terminally ill cancer patients 
   is a multidimensional experience caused by a diverse array of factors - cancer 
   itself, its treatment or other causes. Studies have shown a high incidence of 
   myofascial pain syndrome (MPS) in patients with cancer and the knowledge of 
   myofascial trigger points (MTrPs) is important to address and manage existing 
   pain, and to prevent the recurrence of pain. This review aims to summarize recent 
   advances in interventions for managing MPS in patients with cancer. RECENT 
   FINDINGS: Database searches were conducted on MEDLINE, CINAHL, and Google Scholar 
   to locate all studies published from inception until April 2019 using the 
   keywords cancer pain, myofascial pain, TrPs with emphasis of any methodological 
   quality that included interventions for MPS. MPS in advanced cancer patients are 
   more commonly observed along with other cancer pains rather than independently 
   with a prevalence of 11.9-48% in those patients diagnosed with cancer of head and 
   neck and breast cancer. SUMMARY: Interventional therapies employing ultrasound 
   guided injection of the MTrPs is gaining popularity in the management of MPS in 
   cancer pain and may be a better alternative than the use of opioid analgesics in 
   the multidisciplinary management.
C1 Department of Anesthesia and Pain Management, East Kent University Hospitals, Kent, United Kingdom.
   Department of Anesthesia and Pain Management, University Health Network-Toronto Western Hospital, Ontario, Canada.
   Department of Anesthesia and Pain Management, Charing Cross University Hospital, London, United Kingdom.
NR 0
TC 0
SN 1751-426
EI 
J9 Curr Opin Support Palliat Care
PD JUL 28
PY 2019
VL 13
IS 3
BP 262
EP 269
DI 10.1097/SPC.0000000000000446 
PG 7
WC Acupuncture Therapy; methods; Analgesics; therapeutic use; Anesthetics, Local; therapeutic use; Humans; Myofascial Pain Syndromes; etiology; Neoplasms; complications; Nerve Block; methods; Therapy, Soft Tissue; methods; Trigger Points
UT PubMed:31348012
PM 31348012
DA 2019-07-28
ER

PT J
AU Moran, JM
   Fernández, AS
   Pedrera-Zamorano, JD
AF Moran, Jose M
   Fernández, Antonio S
   Pedrera-Zamorano, Juan D
TI Response to "Assessing the Impact of Acupuncture on Pain, Nausea, Anxiety, and 
SO Oncology nursing forum
LA English
DT Journal Article
DE acupuncture ; mastectomy; nausea; pain
AB We read with interest the pilot randomized, controlled trial by Quinlan-Woodward 
   et al. (2016) published in Oncology Nursing Forum about the impact of acupuncture 
   on pain, nausea, anxiety, and coping in women undergoing a mastectomy. We think 
   that there are both theoretical and methodologic issues that do not allow the 
   authors to conclude that their study demonstrated that acupuncture delivered 
   postoperatively in the hospital after mastectomy can reduce the severity of 
   symptoms experienced and increase the patient's ability to cope with her 
   symptoms. .
C1 University of Extremadura.
   Hospital San Pedro de Alcántara.
   University of Extremadura.
NR 0
TC 0
SN 1538-068
EI 
J9 Oncol Nurs Forum
PD AUG 19
PY 2017
VL 44
IS 5
BP 522
EP 524
DI 10.1188/17.ONF.522-524 
PG 2
WC Acupuncture Therapy; Adaptation, Psychological; Adult; Aged; Aged, 80 and over; Analgesics; therapeutic use; Anti-Anxiety Agents; therapeutic use; Antiemetics; therapeutic use; Anxiety; therapy; Breast Neoplasms; surgery; Female; Humans; Mastectomy; adverse effects; Middle Aged; Nausea; therapy; Pain, Postoperative; etiology
UT PubMed:28820520
PM 28820520
DA 2017-08-19
ER

PT J
AU Zhang, T
   Zhang, Q
   Zhu, P
   Sun, W
   Ding, Z
   Hu, L
AF Zhang, Teng
   Zhang, Qiang
   Zhu, Peiye
   Sun, Weidong
   Ding, Zaiqiao
   Hu, Lu
TI The Efficacy of Acupuncture in the Treatment of Chemotherapy-Induced Peripheral 
SO Alternative therapies in health and medicine
LA English
DT Journal Article
AB BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN), one of the most 
   common adverse events associated with chemotherapy, may affect efficacy because 
   of the interruption of chemotherapy or change of regimen in severe cases, and may 
   even increase cancer mortality. Relevant data supports the evidence that 
   acupuncture can treat pain and sensory abnormalities. However, choosing the most 
   effective acupuncture therapy is difficult because of the lack of evidence-based 
   medicine and comparisons between different acupuncture therapies for treating 
   CIPN. The aim of this study was to use a network meta-analysis (NMA) to evaluate 
   the efficacy of different acupuncture therapies for CIPN. METHODS: We searched 
   Embase, PubMed, Web of Science, The Cochrane Library, The Chinese Journal Full 
   Text Database, Chinese Biomedical Literature Database, and WanFang Database for 
   randomized controlled trials (RCTs) of acupuncture for CIPN. The search period 
   was from the creation of the relevant library to August 10, 2023. A total of 2 
   investigators independently performed literature screening, data extraction, and 
   risk for bias evaluation. Stata 14.0 software (StataCorp LLC, College Station, 
   Texas USA), was used for the NMA. RESULTS: A total of 13 eligible RCTs involving 
   746 patients and 6 acupuncture therapies were included in the study. The NMA 
   results showed that electroacupuncture was superior to moxibustion, manual 
   acupuncture, acupoint injection and Western medicine in improving the total 
   effective rate of treatment of CIPN; electroacupuncture + moxibustion was better 
   than manual acupuncture, acupoint injection, and Western medicine. Manual 
   acupuncture's total effective rate was better than Western medicine. However, 
   electroacupuncture was the most effective treatment for CIPN according to the 
   surface under the cumulative ranking curve (SUCRA) ranking. CONCLUSION: After a 
   comprehensive evaluation of 6 acupuncture therapies for treating CIPN based on 
   NMA, electroacupuncture may be the best option for treating CIPN. However, would 
   be more convincing to get evidence from more RCTs.
NR 0
TC 0
SN 
EI 1078-679
J9 Altern Ther Health Med
PD SEP 14
PY 2023
VL 29
IS 8
BP 898
EP 906
DI 
PG 8
WC Humans; Acupuncture Therapy; methods; Moxibustion; Peripheral Nervous System Diseases; chemically induced; Antineoplastic Agents; adverse effects
UT PubMed:37708563
PM 37708563
DA 2023-09-14
ER

PT J
AU Park, S
   Gu, JH
   Jang, HK
   Oh, MS
   Lee, EJ
   Jung, IC
AF Park, Sohyeon
   Gu, Ji-Hyang
   Jang, Hye-Kyoung
   Oh, Min-Seok
   Lee, Eun-Jung
   Jung, In Chul
TI Electroacupuncture for post-thoracotomy pain: Protocol for a systematic review 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Thoracotomy is a common surgical procedure used in cases such as 
   trauma and cancer resection. It is an invasive procedure in which incisions are 
   made in the chest wall to gain access to the chest. Therefore, it often produces 
   intense postoperative pain. Electroacupuncture has been known for its analgesic 
   effects in various conditions, including cases of postoperative pain. This 
   protocol design is for a systematic review and meta-analysis to gather evidence 
   and investigate the analgesic effects of electroacupuncture in pain after 
   thoracotomy. METHODS: The studies for the systematic review will be searched with 
   keywords on the following 10 databases: PubMed, Cochrane Library (CENTRAL), 
   EMBASE, MEDLINE, Google Scholar, CNKI, KoreaMed, KMBASE, KISS, and OASIS. The 
   search will be done without language restrictions. Only the randomized controlled 
   trials that meet the eligibility criteria will be finally included in the study. 
   The quality of the study will be assessed using the Cochrane Collaborations' 
   risk-of-bias tool, and Cochrane's software RevMan 5.3 will be used for 
   meta-analysis. RESULTS: The designed study will provide a systematic review and 
   meta-analysis of the searched and randomized controlled trials that meet the 
   eligibility criteria. Meta-analysis will be performed with pain scores as the 
   main outcome measure, and they may also be performed with additional outcomes. 
   The qualitative and quantitative data synthesis is expected to provide high 
   quality evidence to judge the pain management effect of electroacupuncture for 
   patients who underwent thoracotomy. CONCLUSION: The conclusion of this systematic 
   review and meta-analysis will provide evidence to judge whether 
   electroacupuncture is an effective analgesic treatment option for patients 
   suffering with post-thoracotomy pain. PROSPERO REGISTRATION NUMBER: 
   CRD42019142157.
C1 College of Korean Medicine.
   Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Dong-Gu.
   Clinical Trial Center, Dunsan Korean Medicine Hospital of Daejeon University, Seo-Gu Daejeon.
   Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Dong-Gu.
   Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Dong-Gu.
   Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University, Dong-Gu, Daejeon, Republic of Korea.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD MAR 3
PY 2020
VL 99
IS 9
BP e19312
EP e19312
DI 10.1097/MD.0000000000019312 
PG 1
WC Electroacupuncture; methods; Humans; Pain, Postoperative; therapy; Systematic Reviews as Topic; Thoracotomy; adverse effects
UT PubMed:32118757
PM 32118757
DA 2020-03-03
ER

PT J
AU Gruenbaum, SE
   Meng, L
   Bilotta, F
AF Gruenbaum, Shaun E
   Meng, Lingzhong
   Bilotta, Federico
TI Recent trends in the anesthetic management of craniotomy for supratentorial tumor 
SO Current opinion in anaesthesiology
LA English
DT Review
AB PURPOSE OF REVIEW: The article reviews the recent evidence on the anesthetic 
   management of patients undergoing craniotomy for supratentorial tumor resection. 
   RECENT FINDINGS: A rapid recovery of neurological function after craniotomy for 
   supratentorial tumor allows for the prompt diagnosis of intracranial 
   complications and possibly an early hospital discharge. Intraoperative esmolol 
   infusion was shown to reduce the anesthetic requirements, and may facilitate a 
   more rapid recovery of neurological function. Outpatient craniotomy for 
   supratentorial tumor resection has been associated with several clinical and 
   economic benefits, but has not gained widespread use because of skepticism and 
   medical-legal concerns. Awake craniotomy is associated with advantageous outcomes 
   compared with surgery under general anesthesia, and is regarded as the standard 
   of care for tumors that reside in or in close proximity to the eloquent brain. 
   Recent studies have demonstrated that intraoperative electroacupuncture, 
   dexmedetomidine, pregabalin, and lidocaine may facilitate postcraniotomy pain 
   management. The use of volatile anesthetic agents in cancer surgery is associated 
   with a worse survival compared with intravenous anesthetics, possibly by 
   hindering immunologic defenses against cancer cells. SUMMARY: Recent evidence has 
   yielded valuable information regarding anesthetic management of patients 
   undergoing supratentorial tumor craniotomy. Despite a plethora of studies that 
   compare short-term outcomes using different anesthetic and analgesic regimens, 
   randomized controlled trials that examine the long-term outcomes (i.e., 
   neurocognitive function, quality of life, tumor recurrence, and survival) that 
   are of particular interest to patients are needed.
C1 aDepartment of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut, USA bDepartment of Anesthesiology, Critical Care and Pain Medicine,'Sapienza' University of Rome, Rome, Italy.
NR 0
TC 0
SN 1473-650
EI 
J9 Curr Opin Anaesthesiol
PD JUN 11
PY 2016
VL 29
IS 5
BP 552
EP 7
DI 10.1097/ACO.0000000000000365 
PG -545
WC Analgesics; therapeutic use; Anesthesia; adverse effects; Anesthetics, Inhalation; administration & dosage; Cognition; drug effects; Craniotomy; adverse effects; Electroacupuncture; Humans; Neoplasm Recurrence, Local; mortality; Pain Management; methods; Pain, Postoperative; therapy; Perioperative Care; methods; Quality of Life; Supratentorial Neoplasms; mortality; Treatment Outcome
UT PubMed:27285727
PM 27285727
DA 2016-06-11
ER

PT J
AU Garcia, MK
   Driver, L
   Haddad, R
   Lee, R
   Palmer, JL
   Wei, Q
   Frenkel, M
   Cohen, L
AF Garcia, M Kay
   Driver, Larry
   Haddad, Robin
   Lee, Richard
   Palmer, J Lynn
   Wei, Qi
   Frenkel, Moshe
   Cohen, Lorenzo
TI Acupuncture for treatment of uncontrolled pain in cancer patients: a pragmatic 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; cancer; complementary medicine; integrative medicine; pain; symptom management
AB PURPOSE: Pain control is an ongoing challenge in the oncology setting. Prior to 
   implementing a large randomized trial at our institution, we investigated the 
   feasibility, safety, and initial efficacy of acupuncture for uncontrolled pain 
   among cancer patients. HYPOTHESES: Our hypotheses were that the acupuncture 
   treatments provided would be ( : ) feasible, ( : ) safe, and ( : ) a beneficial 
   adjunct to pain management. STUDY DESIGN: This was a single arm, nonrandomized 
   pragmatic pilot study. METHODS: Participants experiencing pain ≥4 on a 0 to 10 
   numeric rating scale received a maximum of 10 treatments on an individualized 
   basis. Recruitment, attrition, compliance, and adverse events (AEs) were 
   assessed. Pain (Brief Pain Inventory-Short Form), quality of life (MD Anderson 
   Symptom Inventory [MDASI]), and patient satisfaction were assessed at baseline 
   and at the end of treatment. RESULTS: Of 115 patients screened, 52 (45%) were 
   eligible and agreed to participate. Eleven (21%) were lost to follow-up, leaving 
   41 who completed all study procedures. No AEs were reported. Mean pain SEVERIT: 
   was 6.0 ± 1.3 at baseline and 3.8 ± 2.0 at follow-up ( : < .0001). Pain 
   INTERFERENC: was 6.2 ± 2.3 at baseline and 4.3 ± 2.8 at follow-up ( : < .0011). 
   On the MDASI, the mean symptom SEVERIT: was 4.6 ± 1.8 at baseline and 3.2 ± 1.9 
   at follow-up ( : < .0001), and mean symptom INTERFERENC: was 5.8 ± 2.4 at 
   baseline and 4.1 ± 2.9 at follow-up ( : < .002). Prescribed pain medications 
   decreased across the course of the study. Patient satisfaction was high: 87% 
   reported that their expectations were met "very well" or "extremely well"; 90% 
   said they were likely to participate again; 95% said they were likely to 
   recommend acupuncture to others; and 90% reported they found the service to be 
   "useful" or "very useful." CONCLUSIONS: Acupuncture was feasible, safe, and a 
   helpful treatment adjunct for cancer patients experiencing uncontrolled pain in 
   this study. Randomized placebo-controlled trials are needed to confirm these 
   results.
C1 The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
NR 0
TC 0
SN 1552-695
EI 
J9 Integr Cancer Ther
PD NOV 28
PY 2013
VL 13
IS 2
BP 133
EP 40
DI 10.1177/1534735413510558 
PG -93
WC Acupuncture Therapy; methods; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Neoplasms; complications; Pain; physiopathology; Pain Management; methods; Pilot Projects
UT PubMed:24282103
PM 24282103
DA 2013-11-28
ER

PT J
AU Yang, M
   Baser, RE
   Liou, KT
   Li, SQ
   Piulson, L
   Panageas, KS
   Mao, JJ
AF Yang, Mingxiao
   Baser, Raymond E
   Liou, Kevin T
   Li, Susan Q
   Piulson, Lauren
   Panageas, Katherine S
   Mao, Jun J
TI Effect of acupuncture versus usual care on sleep quality in cancer survivors with 
SO Cancer
LA English
DT Journal Article
DE cancer survivor; chronic pain; clinical trial; integrative care; sleep disturbance
AB BACKGROUND: Chronic pain negatively affects sleep; it is unclear whether pain 
   relief from acupuncture contributes to sleep quality improvements in cancer 
   survivors. This study aimed to evaluate the effect of acupuncture versus usual 
   care on sleep quality among cancer survivors with comorbid sleep disturbance and 
   chronic musculoskeletal pain. METHODS: Sleep outcome data from the Personalized 
   Electroacupuncture Versus Auricular Acupuncture Comparative Effectiveness (PEACE) 
   randomized clinical trial were analyzed. Electroacupuncture or auricular 
   acupuncture was compared with usual care for sleep quality improvement over 10 
   weeks of treatment among cancer survivors with clinically significant sleep 
   disturbance and chronic musculoskeletal pain at baseline. Sleep quality was 
   measured with the Pittsburgh Sleep Quality Index (PSQI) global score. RESULTS: 
   Among 268 participants (mean [standard deviation (SD)] age, 61.4 [12.6] years; 
   191 women [71.3%]; mean [SD] baseline PSQI global score, 10.3 [3.3] points), 
   electroacupuncture and auricular acupuncture resulted in greater reductions in 
   the PSQI global score from baseline to 10 weeks in comparison with usual care: 
   1.42 points (95% confidence interval [CI], 0.45-2.38; p = .004) and 1.59 points 
   (95% CI, 0.62-2.55; p = .001), respectively. The improvement in sleep quality for 
   the acupuncture groups was sustained for 24 weeks from randomization. 
   Furthermore, a greater proportion of patients in the electroacupuncture and 
   auricular acupuncture groups had clinically meaningful improvement in sleep 
   quality compared to the usual care group (41.0% and 42.9% vs. 21.4%; p = .044). 
   CONCLUSIONS: Among cancer survivors with comorbid sleep disturbance and chronic 
   pain, electroacupuncture and auricular acupuncture produced a clinically relevant 
   and persistent improvement in sleep quality. These findings suggest that 
   acupuncture may be an evidence-based nonpharmacologic intervention to improve 
   sleep health for cancer survivors with pain. PLAIN LANGUAGE SUMMARY: This study 
   analyzed the sleep quality data from a published randomized clinical trial that 
   evaluated the effect of electroacupuncture or auricular acupuncture versus usual 
   care on pain relief among people who survived cancer. This analysis included a 
   prespecified subgroup of 268 participants with co-occurring sleep disturbance and 
   chronic musculoskeletal pain at baseline and found that patients who used 
   acupuncture for pain relief demonstrated greater improvements in sleep quality 
   compared with patients who received usual care. Sleep quality improvement by 
   acupuncture was sustained after the treatment ended.
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
NR 0
TC 0
SN 1097-014
EI 0008-543
J9 Cancer
PD MAR 30
PY 2023
VL 129
IS 13
BP 2084
EP 2094
DI 10.1002/cncr.34766 
PG 10
WC Humans; Female; Middle Aged; Chronic Pain; complications; Musculoskeletal Pain; Sleep Quality; Cancer Survivors; Acupuncture Therapy; methods; Treatment Outcome; Neoplasms; complications
UT PubMed:36989257
PM 36989257
DA 2023-03-30
ER

PT J
AU Han, XC
   Xing, QZ
   Li, Y
   Dong, X
   Ma, XW
   Zhang, L
   Wang, QQ
AF Han, Xue-Chang
   Xing, Qun-Zhi
   Li, Yu
   Dong, Xu
   Ma, Xiao-Wu
   Zhang, Lu
   Wang, Qian-Qian
TI [Clinical trial of electroacupuncture at Neimadian-point for cancer pain].
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Analgesia; Cancer; Eletroacupuncture; Neimadian-point; Pain
AB OBJECTIVE: To observe the clinical efficacy and safety of electroacupuncture (EA) 
   at Neimadian-point for cancer pain. METHODS: A total of 140 cancer patients with 
   pain were randomly divided into EA and control groups, with 70 cases in each 
   group. The patients of the EA group received EA at Neimadian-point plus analgesia 
   pump (all prepared with normal saline). The patients of the control group were 
   treated by Sufentanil patient-controlled intravenous analgesia plus sham EA 
   (without stimulation). The treatment was conducted once daily for two days at 8 
   o'clock every morning. Respectively, in 1 h before treatment (T0), 1 h (T1), 8 h 
   (T2), 24 h (T3) after treatment of the first day, 1 h (T4), 8 h (T5), 24 h (T6) 
   after treatment of the second day, the visual analogue scale (VAS) score of pain, 
   and the plasma levels of norepinephrine, 5-HT, leucine enkephalin, β-endorphin 
   and dynorphin A1-13 were tested. The security level (1-4 grade) was assessed 
   during the treatment. RESULTS: Compared with their own pre-treatment, in T1 to 
   T6, the VAS scores, and the contents of plasma norepinephrine and 5-HT obviously 
   decreased in both groups （P<0.05）, and the contents of leucine enkephalin, 
   β-endorphin and dynorphin A1-13 all increased (P<0.05) in the EA group. The 
   analgesia effects were significantly higher in the EA group than in the control 
   group in T1, T2, T4 and T5 (P<0.05,P<0.01). The therapeutic effect of EA at 
   Neimadian-point was significantly superior to that of the Sufentanil in 
   down-regulating plasma norepinephrine and 5-HT levels, and in up-regulating 
   leucine enkephalin, β-endorphin and dynorphin A1-13 levels (P<0.05,P<0.01). 
   CONCLUSION: EA at Neimadian-point can effectively relieve the pain of cancer 
   patients and improve their quality of daily life.
C1 Department of Anesthesiology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003,Henan Province, China.
   Department of Anesthesiology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003,Henan Province, China.
   Department of Anesthesiology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003,Henan Province, China.
   Department of Anesthesiology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003,Henan Province, China.
   Department of Anesthesiology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003,Henan Province, China.
   Department of Anesthesiology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003,Henan Province, China.
   Department of Anesthesiology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003,Henan Province, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD APR 1
PY 2021
VL 45
IS 10
BP 845
EP 50
DI 10.13702/j.1000-0607.200131 
PG -795
WC Cancer Pain; therapy; Electroacupuncture; Humans; Neoplasms; complications; Pain; etiology; Pain Management; beta-Endorphin
UT PubMed:33788453
PM 33788453
DA 2021-04-01
ER

PT J
AU D'Alessandro, E
   de, Brito C
   Cecatto, R
   Saul, M
   Atta, JA
   Lin, CA
AF D'Alessandro, Eduardo
   de Brito, Christina
   Cecatto, Rebeca
   Saul, Maira
   Atta, Jose Antonio
   Lin, Chin An
TI Evaluation of acupuncture for cancer symptoms in a cancer institute in Brazil.
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
AB INTRODUCTION: Acupuncture has been progressively included in the practice of 
   mainstream medicine in recent decades. The State of Sao Paulo Cancer Institute is 
   a public hospital established in 2008 and its acupuncture service follows the 
   experience and model of several oncology centres in the USA, aiming to optimise 
   the treatment of symptoms such as postoperative pain, oncological pain, 
   neuropathic pain, nausea, vomiting, xerostomia and fatigue induced by 
   chemotherapy. This paper describes the population given acupuncture treatment and 
   the effects of the intervention on symptom management. METHODS: One hundred and 
   eighty-three patients from our service were enrolled in the study. Baseline and 
   final symptom intensity was recorded using a visual analogue score (VAS) ranging 
   from 0 to 10 cm, with a higher score meaning higher symptom intensity. RESULTS: 
   Fifty-four (29.50%) were receiving active treatment with chemotherapy and/or 
   radiotherapy, 29 (15.85%) were receiving hormone therapy and 100 (54.65%) were 
   considered to be in remission. The main symptoms were: oncological pain in 44 
   (24.04%), chemotoxicity in 34 (18.6%), lumbar pain in 53 (28.96%) and chronic 
   postoperative pain in 54 (28.4%). The mean (SD) initial symptom score was 7.04 
   (1.8), which was reduced to 2.56 (2.75) after treatment (p<0.001), an improvement 
   of 63.6% in control of the symptoms. Further analysis of the data showed that the 
   effect was similar in different indications for acupuncture treatment. 
   CONCLUSIONS: Use of acupuncture may have improved symptom control in patients 
   enrolled in this study.
C1 Department of Internal Medicine, Sao Paulo State Institute of Cancer, São Paulo, SP 05403-000, Brazil. e.g.dalessandro@gmail.com
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD NOV 3
PY 2012
VL 31
IS 1
BP 23
EP 6
DI 10.1136/acupmed-2012-010206 
PG -17
WC Academies and Institutes; Acupuncture Therapy; Adult; Aged; Aged, 80 and over; Brazil; Female; Humans; Lumbar Vertebrae; Male; Middle Aged; Musculoskeletal Pain; therapy; Neoplasms; complications; Pain Management; Pain, Postoperative; therapy; Treatment Outcome
UT PubMed:23117345
PM 23117345
DA 2012-11-03
ER

PT J
AU Saw, CL
   Chew, L
   Goh, C
AF Saw, Constance L L
   Chew, Lita
   Goh, Cynthia
TI Recent non-interventional advances in cancer pain among Singapore patients.
SO Annals of the Academy of Medicine, Singapore
LA English
DT Review
AB INTRODUCTION: Pain is a common symptom in cancer patients, but very little 
   information about the prevalence, severity, and treatment of pain in cancer 
   patients in Singapore is available. Therefore, our prospective survey in the 
   National Cancer Centre (NCC) outpatients is incorporated in this report. In 
   addition, a review concerning the recent advances on non-interventional pain 
   management in cancer treatment, which is relevant in the context, is discussed. 
   MATERIALS AND METHODS: For the prospective survey, a questionnaire was 
   distributed for self-administration by patients while waiting for consultation at 
   the NCC outpatient departments. Literature searches on advances in pain 
   management were conducted, reviewed and discussed. RESULTS: In the last decade, 
   there have been advances in pain pharmacology ranging from wider therapeutic 
   options and management approaches to novel delivery techniques. Acupuncture and 
   massage therapy became increasingly popular among cancer patients. Some clinical 
   trials of acupuncture show benefits in palliation of cancer pain. From the 
   prospective survey, 41.2% of the responders reported pain in the past week, and 
   only 70.8% talked to their doctors about their pain. One third of the patients 
   received analgesics. Of these, 86.5% said that they were taking the prescribed 
   medications, however, 37.4% admitted to having difficulties taking them. Non-drug 
   methods were used by 25.4% of the patients. Medicated oil, cream or gel was used 
   by 49.3%; only 2.6% reported use of Chinese herbs. CONCLUSION: Pain is a 
   significant symptom in outpatients attending a cancer centre, affecting 41.2% of 
   the patients. Although majority of patients who suffered from pain reported this 
   to doctors, much more medical effort is needed to help patients to relieve their 
   pain and proper complementary therapy could be considered.
C1 Department of Pharmacy, National Cancer Centre, Singapore. constancesaw@gmail.com
NR 0
TC 0
SN 2972-406
EI 
J9 Ann Acad Med Singap
PD OCT 12
PY 2012
VL 41
IS 9
BP 407
EP 16
DI 
PG -391
WC Acupuncture Therapy; Adult; Aged; Aged, 80 and over; Analgesics; therapeutic use; Complementary Therapies; Female; Health Care Surveys; Humans; Male; Massage; Middle Aged; Neoplasms; complications; Outpatients; Pain; drug therapy; Pain Measurement; Phytotherapy; Prevalence; Prospective Studies; Severity of Illness Index; Singapore; epidemiology; Time Factors
UT PubMed:23052435
PM 23052435
DA 2012-10-12
ER

PT J
AU Utli, H
   Dinç, M
   Utli, MDA
AF Utli, Hediye
   Dinç, Mahmut
   Utli, Medical Doctor Adil
TI The effect of acupressure or reiki interventions on the levels of pain and 
SO Explore (New York, N.Y.)
LA English
DT Journal Article
DE Acupressure; Analgesic use; Cancer pain; Fatigue; Palliative care; Reiki
AB OBJECTIVE: Taking pain under control is important to calm the individual and 
   reduce complications. This research was conducted with the aim of determining the 
   effect of Acupressure or Reiki interventions on the levels of pain and fatigue of 
   stage III and IV cancer patients receiving palliative care. METHOD: The research 
   was a single-blind, repeated measures, randomized controlled study. Research data 
   were collected between February and November 2022. The research sample consisted 
   of Acupressure and Reiki intervention groups and a control group with 52 patients 
   in each group for a total of 156 patients. Acupressure or Reiki was applied to 
   their intervention groups for a total of eight sessions of 20 min each over four 
   weeks, once a day on two days a week. Data were collected by means of a patient 
   description form, an analgesic follow-up form, the Numeric Pain Rating Scale, and 
   the Brief Fatigue Inventory. RESULTS: In comparison with the control group, a 
   significant reduction was seen over time in the levels of pain (p < 0.001), 
   analgesic use (p < 0.001), and fatigue (p < 0.001) in the Acupressure or Reiki 
   intervention groups. CONCLUSION: Acupressure or Reiki interventions were found to 
   effective in reducing levels of pain, analgesic use, and fatigue. It was seen 
   that in addition to their use in routine nursing care, both treatments can be 
   accepted as effective nursing interventions that reduce pain and fatigue in stage 
   III and IV cancer patients receiving palliative care.
C1 Department of Elderly Care, Vocational School of Health Services, Mardin Artuklu University, Mardin, Turkey. 
   Faculty of Health Sciences, Department of Nursing, Batman University, Batman, Turkey.
   Department of Emergency Medicine, Eskişehir Osmangazi Faculty of Medicine, Eskişehir, Turkey.
EM hediyeutli@artuklu.edu.tr
NR 0
TC 0
SN 1878-754
EI 
J9 Explore (NY)
PD DEC 9
PY 2022
VL 19
IS 1
BP 91
EP 99
DI 10.1016/j.explore.2022.11.007 
PG 8
WC Humans; Therapeutic Touch; Acupressure; Palliative Care; Single-Blind Method; Pain; etiology; Neoplasms; complications; Analgesics; Fatigue; therapy
UT PubMed:36476354
PM 36476354
DA 2022-12-09
ER

PT J
AU Fink, J
   Burns, J
   Perez, Moreno AC
   Kram, JJF
   Armstrong, M
   Chopp, S
   Maul, SJ
   Conway, N
AF Fink, Jennifer
   Burns, John
   Perez Moreno, Ana Christina
   Kram, Jessica J F
   Armstrong, Melissa
   Chopp, Sara
   Maul, Scott J
   Conway, Nancy
TI A Quality Brief of an Oncological Multisite Massage and Acupuncture Therapy 
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
DE acupuncture treatment; cancer-related symptoms; massage treatment
AB Objectives: Cancer treatment can present its own physical and mental challenges 
   resulting in symptoms such as fatigue, stress, pain, nausea, and vomiting. Aurora 
   Health Care is a large health system with 19 cancer centers. Integrative 
   therapies such as acupuncture and massage have demonstrated success in reducing 
   cancer-related symptoms and side effects to conventional cancer treatment and 
   improving patient outcomes. In 2018, 15 of the 19 Aurora Cancer Clinics embedded 
   a replicable Integrative Cancer Care closed model to provide adjuvant therapies 
   for the best patient outcomes. This quality improvement study aimed to explore if 
   the replicable integrative care model could demonstrate consistent outcomes for 
   massage and acupuncture therapies aimed at symptom reduction across multiple 
   oncology clinics. Design: Aurora Cancer Care and Aurora Integrative Medicine 
   designed a reproducible integrative therapy service model to be embedded into the 
   Aurora Cancer Centers. Integrative therapies within the cancer centers allow 
   patients easy access to care before, during, or after their cancer treatment. In 
   2018, 15 of the 19 cancer clinics had integrative therapies available to patients 
   with cancer. This model required unified operations, onboarding, training, 
   competency, and clinical oversight to achieve consistent processes for consistent 
   outcomes. Furthermore, these innovative models prioritized the following: patient 
   access (easy and affordable); service delivery (consistent and operationalized); 
   clinical outcomes (effective and meaningful); and caliber of clinician (competent 
   and confident). Aurora Health Care employs massage therapists (Mts) and 
   acupuncturists (Ats). This employment model allows for standards and program 
   model adherence. To achieve competent and confident clinician's, MT or AT must 
   complete a cancer treatment-focused competency training program relative to their 
   respective profession and adherence to practice standards outlined. The training 
   program is built on evidence-based practice, observation, direct demonstration, 
   return demonstration, mentorship, and ongoing quality review by clinical leaders. 
   Aurora's Integrative Cancer Care closed model of care is accessible to patients 
   through philanthropic funds secured to underwrite the free service of MT provided 
   during infusion treatments. Funds also provided three free AT sessions. Ongoing 
   acupuncture therapies were provided at a low-cost group acupuncture fee at $25.00 
   per treatment. Acupuncture is available in group format and provided either 
   before or after chemotherapy treatment. The free services were intended to 
   introduce the concept of integrative therapies as a viable adjuvant option with 
   conventional cancer care. As this model incorporates a mix of philanthropic 
   funding and low-cost fees to offset the cost of the therapy provider, it is 
   referred to as a "closed model" or accessible only to those patients under the 
   care of an Aurora Cancer specialist. In 2018, 15 Aurora Cancer Clinics offered 
   massage and 11 Aurora Cancer Clinics offered acupuncture. Patients who 
   self-selected integrative therapies via system-employed Mts and Ats were surveyed 
   pre/post acupuncture and MT treatments using a visual analog scale about their 
   perceived levels of pain, stress, nausea, and neuropathy. The staff integrative 
   clinicians collected data from patients, and post-treatment data were compiled by 
   the Department of Integrative Medicine. Settings/Location: Aurora Cancer Centers 
   are embedded within Aurora hospitals or free-standing clinics located throughout 
   Wisconsin. In 2018, 15 cancer clinic locations embedded Mts, and 11 cancer clinic 
   locations embedded Ats. Subjects: Oncology patients. Interventions: Clinical 
   competencies were developed and applied to address indications, 
   contraindications, and oncology-specific procedures to ensure that consistent 
   quality of therapies was provided across sites. In 2018, Ats delivered 4367 Ats 
   across 11 locations and Mts delivered 4197 Mts across 15 locations. During this 
   study, the number of treatments provided was tracked versus episodic care. 
   Outcome Measures: Pre/post AT and MT pain, stress, nausea, and neuropathy scores 
   were recorded (0 [least] to 10 [worst]) and compared using paired t-tests. 
   Results: Pre/post AT scores for pain, neuropathy, stress, and nausea were all 
   significantly different (p < 0.001). For AT, there was a reported decrease in 
   pain, stress, and neuropathy of 61.7%, 68.8%, and 47.9%, respectively. Pre/post 
   MT scores for pain, neuropathy, nausea, and stress were also significantly 
   different (p < 0.001). MT was greater at reducing stress and pain, 42.5% and 
   34.4%, respectively. Conclusions: Across 15 cancer clinics, both AT and MT 
   treatments consistently and significantly reduced cancer-related side effects. 
   These findings highlight the value of conducting a larger randomized-controlled 
   trial to further assess the impact of Oncological Multisite Massage and 
   Acupuncture Therapy on cancer-related symptoms across multiple oncologic clinics.
C1 Department of Health Informatics and Administration, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
   Department of Integrative Medicine, Aurora Health Care, Aurora Sinai Medical Center, Milwaukee, WI, USA.
   Aurora Research Institute, Aurora Health Care, Milwaukee, WI, USA.
   Aurora UW Medical Group and Center for Urban Population Health, Aurora Health Care, Aurora Sinai Medical Center, Milwaukee, WI, USA.
   Department of Integrative Medicine, Aurora Health Care, Aurora Sinai Medical Center, Milwaukee, WI, USA.
   Department of Health Informatics and Administration, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
   Department of Oncology, Aurora Health Care, Milwaukee, WI, USA.
   Department of Integrative Medicine, Aurora Health Care, Aurora Sinai Medical Center, Milwaukee, WI, USA.
NR 0
TC 0
SN 1557-770
EI 
J9 J Altern Complement Med
PD SEP 15
PY 2020
VL 26
IS 9
BP 820
EP 824
DI 10.1089/acm.2019.0371 
PG 4
WC Acupuncture; Acupuncture Therapy; Ambulatory Care Facilities; Humans; Integrative Medicine; Integrative Oncology; Massage; Medical Oncology; Nausea; etiology; Neoplasms; complications; Pain; etiology; Pain Management; Palliative Care; Peripheral Nervous System Diseases; etiology; Program Evaluation; Stress, Psychological; etiology; Surveys and Questionnaires; Treatment Outcome; Vomiting
UT PubMed:32924553
PM 32924553
DA 2020-09-15
ER

PT J
AU Miller, KR
   Patel, JN
   Symanowski, JT
   Edelen, CA
   Walsh, D
AF Miller, Katherine R
   Patel, Jai N
   Symanowski, James T
   Edelen, Connie A
   Walsh, Declan
TI Acupuncture for Cancer Pain and Symptom Management in a Palliative Medicine 
SO The American journal of hospice & palliative care
LA English
DT Journal Article
DE acupuncture; cancer; pain; palliative; supportive care; symptom
AB OBJECTIVE: Studies suggest acupuncture improves cancer-related symptoms; however, 
   it is unclear whether patient characteristics predict pain response. This study 
   determined acupuncture's effect on cancer-related pain and identified variables 
   associated with pain response. METHODS: A retrospective chart review included 
   adult patients with cancer referred to palliative medicine and received 
   acupuncture for pain management. Paired t tests compared differences in pain 
   scores from pre- to postacupuncture. Clinically meaningful pain improvement was 
   defined as ≥2-point reduction in pain score. Logistic regression was used to 
   evaluate associations between patient characteristics and pain improvement. 
   RESULTS: One hundred seventy acupuncture treatments from 68 individual patients 
   were studied. Significant reductions in mean pain scores were observed after the 
   first treatment (-1.9 ± 1.8; P < .001) and across all treatments (-1.7 ± 1.9; P < 
   .001). Multivariable analysis demonstrated clinically meaningful pain improvement 
   with higher baseline pain scores (odds ratio [OR]: 1.79, 95% confidence interval 
   [CI]: 1.44-2.22; P < .001) and stage III/IV disease (OR: 3.23, 95% CI: 1.11-9.40; 
   P < .001). There were significant improvements in anxiety, depression, 
   drowsiness, dyspnea, fatigue, nausea, and well-being after the first treatment 
   and across all treatments ( P < .001). CONCLUSIONS: Acupuncture improved 
   cancer-related pain and other symptoms. Those with higher baseline pain scores 
   and advanced disease were more likely to achieve significant pain reduction. 
   Improved depression and fatigue were closely related to pain reduction. Further 
   studies are needed to confirm pain response variables, establish durability, and 
   develop a personalized approach to acupuncture.
C1 1 Department of Cancer Pharmacology, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
   1 Department of Cancer Pharmacology, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
   2 Section of Palliative Medicine, Department of Supportive Oncology, Atrium 
   3 Department of Biostatistics, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
   2 Section of Palliative Medicine, Department of Supportive Oncology, Atrium Health, Charlotte, NC, USA.
   2 Section of Palliative Medicine, Department of Supportive Oncology, Atrium Health, Charlotte, NC, USA.
NR 0
TC 0
SN 1938-271
EI 
J9 Am J Hosp Palliat Care
PD OCT 6
PY 2018
VL 36
IS 4
BP 326
EP 332
DI 10.1177/1049909118804464 
PG 6
WC Acupuncture Therapy; methods; Adult; Age Factors; Aged; Aged, 80 and over; Cancer Pain; complications; Fatigue; etiology; Female; Health Status; Humans; Logistic Models; Male; Mental Health; statistics & numerical data; Middle Aged; Pain Measurement; Palliative Care; methods; Retrospective Studies; Severity of Illness Index; Sex Factors
UT PubMed:30286611
PM 30286611
DA 2018-10-06
ER

PT J
AU Romero, SAD
   Emard, N
   Baser, RE
   Panageas, K
   MacLeod, J
   Walker, D
   Barton-Burke, M
   Liou, K
   Deng, G
   Farrar, J
   Xiao, H
   Mao, JJ
   Epstein, A
AF Romero, Sally A D
   Emard, Nicholas
   Baser, Raymond E
   Panageas, Katherine
   MacLeod, Jodi
   Walker, Desiree
   Barton-Burke, Margaret
   Liou, Kevin
   Deng, Gary
   Farrar, John
   Xiao, Han
   Mao, Jun J
   Epstein, Andrew
TI Acupuncture versus massage for pain in patients living with advanced cancer: a 
SO BMJ open
LA English
DT Journal Article
DE cancer pain; complementary medicine; pain management
AB INTRODUCTION: Pain, comorbid fatigue and sleep disturbances are common and 
   distressing symptoms for patients with advanced cancer, negatively impacting 
   their quality of life. Clinical guidelines recommend non-pharmacological 
   interventions, including acupuncture and massage, for pain management in adult 
   patients with cancer in adjunct to conventional care. However, high-quality 
   evidence about the comparative effectiveness and long-term durability of these 
   therapies for symptom management is limited. METHODS AND ANALYSIS: We describe 
   the design of a two-arm, parallel group, multicentre randomised controlled trial 
   that investigates the use of acupuncture versus massage for musculoskeletal pain 
   among 300 patients with diverse types of advanced cancer. The primary aim is to 
   evaluate the long-term effectiveness (26 weeks from randomisation) of acupuncture 
   vs massage for pain (primary outcome) and comorbid symptoms (fatigue, sleep 
   disturbance and quality of life). The secondary aim is to identify patient-level 
   demographic characteristics (eg, sex, race, age), clinical factors (eg, insomnia, 
   pain severity) and psychological attributes that are associated with a greater 
   reduction in pain for either acupuncture or massage. Patients will receive weekly 
   acupuncture or massage treatments for 10 weeks, followed by monthly booster 
   sessions up to 26 weeks. The primary endpoint will be the change in worst pain 
   intensity score from baseline to 26 weeks. We will collect validated 
   patient-reported outcomes at multiple time points over 26 weeks. ETHICS AND 
   DISSEMINATION: The Institutional Review Board at Memorial Sloan Kettering Cancer 
   Center in New York approved this protocol. Results will be disseminated via 
   peer-reviewed scientific journals and conference presentations. Our findings will 
   help patients and healthcare providers make informed decisions about 
   incorporating non-pharmacological treatments to manage pain for patients with 
   advanced cancer. TRIAL REGISTRATION NUMBER: NCT04095234.
C1 Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, CA, USA.
   Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Office of Nursing Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA maoj@mskcc.org.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD DEC 30
PY 2022
VL 12
IS 9
BP e058281
EP e058281
DI 10.1136/bmjopen-2021-058281 
PG 1
WC Adult; Humans; Quality of Life; Acupuncture Therapy; methods; Massage; Musculoskeletal Pain; complications; Neoplasms; complications; Fatigue; complications; Treatment Outcome; Randomized Controlled Trials as Topic; Multicenter Studies as Topic
UT PubMed:36581960
PM 36581960
DA 2022-12-30
ER

PT J
AU Kang, HS
   Jeong, D
   Kim, DI
   Lee, MS
AF Kang, Hyun-Sun
   Jeong, Daun
   Kim, Dong-Il
   Lee, Myeong Soo
TI The use of acupuncture for managing gynaecologic conditions: An overview of 
SO Maturitas
LA English
DT Journal Article
AB Acupuncture is increasingly popular for the treatment of many medical complaints, 
   including gynaecologic conditions. The aim of this study was to summarise the 
   evidence from systematic reviews (SRs) and meta-analyses assessing the efficacy 
   of acupuncture in treating common gynaecologic conditions. Six electronic 
   databases, including two major English-language databases (PubMed and the 
   Cochrane Library) and four Korean databases, were systematically searched for SRs 
   and meta-analyses concerned with acupuncture and common gynaecologic diseases. 
   The following English search terms were used: (gynaecologic disease in MeSH 
   terms) AND (acupuncture or acup*) AND (systematic review OR meta-analysis). In 
   addition, three Korean traditional medicine journals (The Journal of the Korean 
   Acupuncture and Moxibustion Society, The Journal of Korean Oriental Medicine and 
   The Journal of Oriental Obstetrics and Gynaecology) were searched. The quality of 
   the included studies was assessed using the Overview Quality Assessment 
   Questionnaire. Of the 55 potentially relevant studies that were found, 16 SRs 
   were included in this report. These reviews evaluated the efficacy of acupuncture 
   for treating the side effects of breast cancer chemotherapy, menstrual 
   disturbances, menopausal symptoms, female infertility, uterine fibroids and 
   polycystic ovary syndrome. Acupuncture was clearly beneficial in the management 
   of chemotherapy-induced nausea and vomiting. In addition, current evidence 
   suggests that acupuncture administered close to embryo transfer during in vitro 
   fertilisation treatment improves the rates of pregnancy and live birth. In 
   conclusion, there is no convincing evidence of the efficacy of acupuncture except 
   for specific conditions, which include acupuncture administered with embryo 
   transfer to improve the outcome of in vitro fertilisation and acupuncture for the 
   management of chemotherapy-induced nausea and vomiting. More well-designed trials 
   using rigorous methodology are required to evaluate the efficacy of acupuncture 
   in treating gynaecologic conditions.
C1 Department of Obstetrics & Gynecology, College of Korean Medicine, Dongguk University, Ilsan, South Korea.
NR 0
TC 0
SN 1873-411
EI 
J9 Maturitas
PD MAR 8
PY 2011
VL 68
IS 4
BP 346
EP 54
DI 10.1016/j.maturitas.2011.02.001 
PG -292
WC Acupuncture Therapy; Antineoplastic Agents; adverse effects; Breast Neoplasms; drug therapy; Dysmenorrhea; therapy; Female; Humans; Infertility, Female; therapy; Leiomyoma; therapy; Live Birth; Menopause; Meta-Analysis as Topic; Nausea; chemically induced; Polycystic Ovary Syndrome; therapy; Pregnancy; Review Literature as Topic; Vomiting; chemically induced
UT PubMed:21376483
PM 21376483
DA 2011-03-08
ER

PT J
AU Cohen, SA
   Veleber, S
   Siman, J
   Guthrie, KA
   McMillen, K
   Heit, M
   Wadhera, S
   Daniels, J
   Hansen, K
   Jacoby, M
   Taromina, K
   Chin, S
   Romeo, M
   Langley, BO
   Coveler, AL
   Hannan, LM
   King, G
   Purcell, T
   Safyan, RA
   Shankaran, V
   Zhen, DB
   Chiorean, EG
   Greenlee, H
AF Cohen, Stacey A
   Veleber, Susan
   Siman, Jonathan
   Guthrie, Katherine A
   McMillen, Kerry
   Heit, Madilyn
   Wadhera, Sonia
   Daniels, Jonathan
   Hansen, Kjell
   Jacoby, Madeline
   Taromina, Katherine
   Chin, Samantha
   Romeo, Melissa
   Langley, Blake O
   Coveler, Andrew L
   Hannan, Lindsay M
   King, Gentry
   Purcell, Tom
   Safyan, Rachael A
   Shankaran, Veena
   Zhen, David B
   Chiorean, E Gabriela
   Greenlee, Heather
TI Use of acupuncture with acupressure in addition to standard-of-care cryotherapy 
SO Contemporary clinical trials
LA English
DT Journal Article
DE Colorectal cancer; Oxaliplatin; Pancreatic cancer; Peripheral neuropathy
AB BACKGROUND: Oxaliplatin is a key chemotherapeutic agent in the treatment of local 
   and metastatic gastrointestinal (GI) malignancies. Dose density and treatment 
   adherence can be limited by chemotherapy-induced peripheral neuropathy (CIPN). 
   Early research suggests CIPN incidence and severity may be mitigated by 
   acupuncture, but rigorous data in GI oncology patients is limited. Here, we 
   describe the protocol of a randomized, waitlist-controlled pilot study testing 
   the use of preemptive of acupuncture plus acupressure to decrease CIPN and 
   chemotherapy-related toxicities. METHODS: Patients with a GI malignancy (n = 56) 
   with planned 5-fluorouracil (5-FU) and oxaliplatin IV (FOLFOX, FOLFIRINOX) every 
   2 weeks are being recruited. Additional concurrent anti-neoplastic agents may be 
   used. Enrolled patients are randomized 1:1 to a 3-month intervention of Arm A: 
   acupuncture with acupressure and standard-of-care treatment, or Arm B: 
   standard-of-care alone. In Arm A, on days 1 and 3 of each chemotherapy cycle a 
   standardized acupuncture protocol is administered and patients are taught 
   self-acupressure to perform daily between chemotherapy treatments. Patients in 
   both arms are given standard-of-care oral and peripheral (hands/feet) ice chip 
   cryotherapy during oxaliplatin administration. CIPN and other symptoms are 
   assessed at baseline, 6 weeks, and 3 months from registration. The primary 
   endpoint is CIPN severity at 3 months (EORTC-CIPN 20). Additional endpoints 
   evaluate CIPN incidence (CTCAE, Neuropen, tuning fork); incidence of pain, 
   fatigue, nausea, oral dysesthesia, and anxiety; and feasibility (recruitment, 
   retention, adherence, acceptability). If warranted, trial results will inform the 
   design of a multi-center trial to expand testing of the intervention to a larger 
   patient cohort.
C1 Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA. 
   Integrative Medicine Program, Division of Supportive Care, Fred Hutchinson Cancer Center, USA
   Division of Public Health Sciences, Fred Hutchinson Cancer Center,USA.
   Integrative Medicine Program, Division of Supportive Care, Fred Hutchinson Cancer Center, USA
   Division of Public Health Sciences, Fred Hutchinson Cancer Center,USA.
   Division of Public Health Sciences, Fred Hutchinson Cancer Center, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Integrative Medicine Program, Division of Supportive Care, Fred Hutchinson Cancer Center, USA.
   Integrative Medicine Program, Division of Supportive Care, Fred Hutchinson Cancer Center, USA.
   Integrative Medicine Program, Division of Supportive Care, Fred Hutchinson Cancer Center, USA.
   Integrative Medicine Program, Division of Supportive Care, Fred Hutchinson Cancer Center, USA
   Division of Public Health Sciences, Fred Hutchinson Cancer Center,USA
   Department of Child, Family, and Population Health Nursing, University ofWashington, Seattle, WA 98195, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Division of Medical Oncology, University of Washington School of Medicine, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA.
   Clinical Research Division, Fred Hutchinson Cancer Center, 825 Eastlake Ave E, Seattle, WA 98109, USA
   Division of Medical Oncology, University of WashingtonSchool of Medicine, USA
   Integrative Medicine Program, Division of SupportiveCare, Fred Hutchinson Cancer Center, USA
   Division of Public Health Sciences,Fred Hutchinson Cancer Center, USA.
EM shiovitz@uw.edu
NR 0
TC 0
SN 1559-203
EI 1551-714
J9 Contemp Clin Trials
PD JUN 29
PY 2023
VL 131
IS 
BP 107273
EP 107273
DI 10.1016/j.cct.2023.107273 
PG 0
WC Humans; Oxaliplatin; adverse effects; Antineoplastic Combined Chemotherapy Protocols; adverse effects; Feasibility Studies; Acupressure; Pancreatic Neoplasms; Antineoplastic Agents; adverse effects; Peripheral Nervous System Diseases; chemically induced; Acupuncture Therapy; adverse effects; Gastrointestinal Neoplasms; drug therapy; Cryotherapy; Randomized Controlled Trials as Topic; Multicenter Studies as Topic
UT PubMed:37380021
PM 37380021
DA 2023-06-29
ER

PT J
AU Yin, Y
   Wang, L
   Zhao, L
   Lin, L
   Shen, X
AF Yin, Yue
   Wang, Lina
   Zhao, Ling
   Lin, Lin
   Shen, Xueyong
TI Effect of 10.6 μm laser moxibustion on inflammation in diabetic peripheral 
SO Frontiers in endocrinology
LA English
DT Journal Article
DE NF- kappa B; diabetes mellitus; diabetic peripheral neuropathy; inflammation; laser moxibustion
AB Diabetic peripheral neuropathy (DPN) is the main cause of disability in diabetes 
   patients but the efficacy of available drugs is poor. Moxibustion is an 
   adjunctive treatment for DPN that can reduce symptoms. The peak value of the far 
   infrared wavelength of 10.6 μm laser moxibustion is close to the infrared 
   radiation spectrum of traditional moxibustion. Its effect is similar to that of 
   moxibustion and does not cause pain, infection or produce irritating smoke. 
   Twenty-four male SD rats were divided into control (Con), DPN, laser moxibustion 
   (LM), and pyrrolidine dithiocarbamate (PDTC) groups (n=6/group). The DPN, LM and 
   PDTC group rats were intraperitoneally injected with 1% streptozotocin (STZ) to 
   induce a model of DPN. LM group rats were irradiated with a laser at bilateral 
   ST36 acupoints for 15 min, once every other day, for 14 days. PDTC group rats 
   were intraperitoneally injected with PDTC once a day. Body weight, blood glucose, 
   and paw withdrawal mechanical threshold (PWMT) were measured and laser speckle 
   imaging (LSI) performed before and after modeling and at 1 and 2 weeks after 
   intervention. Two weeks after intervention, changes in serum interleukin 1β 
   (IL1β), interleukin 6 (IL6), tumor necrosis factor α (TNFα) and nerve growth 
   factor (NGF) were analyzed, and the abundance of NF-κB and IκB-α proteins and 
   levels of NF-κB and IκB-α mRNAs in the sciatic nerve were observed. The results 
   showed that 10.6 μm laser moxibustion can relieve pain, improve microcirculation, 
   and alleviate inflammation in DPN rats, possibly via the NF-κB inflammatory 
   pathway.
C1 School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   School of Nursing, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Laboratory of Systemic Physiology for Acupuncture and Meridian, Shanghai Research 
NR 0
TC 0
SN 1664-239
EI 1664-239
J9 Front Endocrinol (Lausanne)
PD AUG 18
PY 2023
VL 14
IS 
BP 1203677
EP 1203677
DI 10.3389/fendo.2023.1203677 
PG 0
WC Male; Animals; Rats; Rats, Sprague-Dawley; NF-kappa B; Diabetic Neuropathies; therapy; Moxibustion; NF-KappaB Inhibitor alpha; Inflammation; therapy; Lasers; Diabetes Mellitus
UT PubMed:37593350
PM 37593350
DA 2023-08-18
ER

PT J
AU Lam, TY
   Lu, LM
   Ling, WM
   Lin, LZ
AF Lam, To-Yi
   Lu, Li-Ming
   Ling, Wai-Man
   Lin, Li-Zhu
TI A pilot randomized controlled trial of acupuncture at the Si Guan Xue for cancer 
SO BMC complementary and alternative medicine
LA English
DT Journal Article
DE Acupuncture; Cancer pain; Randomized controlled trial; Si guan Xue
AB BACKGROUND: Pain is a common symptom in cancer patients. Acupuncture is a 
   suggested treatment for a wide range of clinical conditions, usually for its 
   beneficial effects on pain control. Si guan xue (the four points) have been 
   widely used in clinical practice, and has shown that it is highly effective, 
   effective in obtaining qi, shows strong acupuncture stimulation, and is simple to 
   manipulate and safe to use. Therefore, the aim of this study is to test the 
   protocol and safety of acupuncture at the si guan xue in the management of cancer 
   pain. METHODS: This is a single-blind, randomized controlled pilot trial. 42 
   patients with moderate to severe cancer pain were randomly assigned to three 
   different arms with seven sessions of treatment; that is, treatment arm 1 (the si 
   guan xue arm, n = 14), treatment arm 2 (the si guan xue plus commonly used 
   acupoints arm, n = 14) and the control arm (the commonly used acupoints arm 
   n = 14). Primary outcomes included acupuncture relieving cancer pain, and 
   patients' subjective improvement as measured by the Patient Global Impression of 
   Change (PGIC). Secondary outcomes included the scores of the European 
   Organization for Research and Treatment of Cancer Quality of Life 
   Questionnaire-Core 30 (EORTC QLQ-C30) and Karnofsky's Performance Status (KPS). 
   RESULTS: The analysis showed that the cancer pain reduction in treatment arm 2 
   was most prominent on day 5 when compared with the control arm (P<0.05). There 
   was no difference in the scores of PGIC, EORTC QLQ-C30 or KPS among the three 
   groups (P>0.05). Furthermore, no serious adverse events were observed. 
   CONCLUSIONS: These results indicate that acupuncture at the si guan xue plus 
   commonly used acupoints tends to be effective in reducing cancer pain. However, 
   the sample size was small, and a future multi-centre study with a larger sample 
   size is warranted. TRIAL REGISTRATION: ChiCTR-IOR-15007471 (Retroactively 
   registered on 28 NOV 2015).
C1 Department of Oncology, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
   The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, China.
   Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong.
   Department of Oncology, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. lizhulin903@139.com.
NR 0
TC 0
SN 1472-688
EI 
J9 BMC Complement Altern Med
PD JUN 28
PY 2017
VL 17
IS 1
BP 335
EP 335
DI 10.1186/s12906-017-1838-5 
PG 0
WC Acupuncture Analgesia; Acupuncture Points; Acupuncture Therapy; Adult; Aged; Aged, 80 and over; Cancer Pain; therapy; Female; Humans; Male; Middle Aged; Pilot Projects; Single-Blind Method; Treatment Outcome
UT PubMed:28651642
PM 28651642
DA 2017-06-28
ER

PT J
AU Liu, XM
   Wang, GX
   Xue, MX
AF Liu, Xiao-Meng
   Wang, Guo-Xin
   Xue, Ming-Xin
TI [Professor SHAO Ming-xi's experience in differentiation and treatment of 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE SHAO Ming-xi; acupuncture-moxibustion; arthralgia; breast cancer; famous doctor's experience; tuina
AB Professor SHAO Ming-xi 's experience in treatment of arthralgia in breast cancer 
   is summarized. Professor SHAO believes that the dysfunction of liver, spleen and 
   kidney is the primary and the invasion of the exogenous wind, cold and damp is 
   the secondary in arthralgia in breast cancer. Emphasized on syndrome/pattern 
   differentiation, this disorder is identified as 4 patterns, i.e. liver qi 
   stagnation, blockage by phlegm and stasis, qi and blood deficiency and 
   obstruction by wind, cold and damp. Acupuncture-moxibustion is applied to Hegu 
   (LI 4), Taichong (LR 3) and Waiguan (TE 5). The supplementary acupoints are 
   selected on the base of syndrome/pattern differentiation. Tuina is combined with 
   acupuncture-moxibustion and the reinforcing and reducing techniques are used 
   appropriately. Shaoyang meridian is specially considered, due to which, Waiguan 
   (TE 5) and Zhongzhu (TE 3) of triple energizer meridian of hand-shaoyang and 
   Yanglingquan (GB 34) and Zulinqi (GB 41) of gallbladder meridian of foot-shaoyang 
   are combined. Additionally, it stresses the combination of the local and distal 
   acupoints and the coordination of various therapies of TCM to achieve the better 
   effect.
C1 First Clinical Medical School of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
   First Clinical Medical School of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
   First Clinical Medical School of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAY 19
PY 2021
VL 41
IS 5
BP 541
EP 4
DI 10.13703/j.0255-2930.20200326-k0003 
PG -537
WC Acupuncture; Acupuncture Points; Acupuncture Therapy; Arthralgia; Breast Neoplasms; therapy; Humans; Moxibustion
UT PubMed:34002570
PM 34002570
DA 2021-05-19
ER

PT J
AU Zhou, XL
   Wang, H
   Wu, S
   Li, J
   Wu, F
   Lu, W
   Zhao, JW
   Li, YH
AF Zhou, Xu-Liu
   Wang, Hua
   Wu, Song
   Li, Jia
   Wu, Fan
   Lu, Wei
   Zhao, Jia-Wei
   Li, Yi-Hong
TI Comparison of the effects of moxibustion and acupuncture of combined "Biao-Ben" 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acupuncture; Combined “Biao-Ben” acupoints; Diarrhea-predominant irritable bowel syndrome; Heart rate variability; Inflammatory cytokines; Moxibustion
AB OBJECTIVES: To compare the effects of moxibustion and acupuncture of combined 
   "Biao-Ben" acupoints (Biao indicates pathogenic factors of disease, Ben refers to 
   body constitution) on a rat model of irritable bowel syndrome with diarrhea 
   (IBS-D). METHODS: Forty female SD rats were randomly divided into 4 groups：normal 
   group, model group, moxibustion group, and acupuncture group, with 10 rats in 
   each group. The IBS-D rat model was established by administering acute-chronic 
   stress combined with folium sennae gavage for 28 days. Rats in the moxibustion 
   group received moxibustion at bilateral "Zusanli"(ST36), "Guanyuan"(CV4), and 
   "Neiguan"(PC6), while those in the acupuncture group received acupuncture at the 
   same acupoints, both for 15 min every time, once a day. The treatments were 
   administered for 21 days. The loose stool rate was observed. Colonic pain 
   threshold and colonic distension threshold were measured by a self-made balloon 
   catheter. Total distance traveled and grid crossing numbers were observed by open 
   field test. Heart rate variability(HRV) time domain indexes SDANN and PNN50 were 
   acguired by using electrophysiological recorder. Histopathological changes in the 
   colon tissue were observed after HE staining. Contents of interleukin-6(IL-6), 
   IL-8, and tumor necrosis factor-alpha(TNF-α) in serum were detected by ELISA. 
   RESULTS: Compared with the normal group, rats in the model group showed increased 
   loose stool rate(P<0.05), decreased pain threshold and distension 
   threshold(P<0.05), reduced total distance traveled and grid crossing numbers in 
   the open field test(P<0.05), decreased HRV time domain indexes SDANN and 
   PNN50(P<0.01, P<0.05), and elevated levels of serum IL-6, IL-8, and TNF-α 
   contents(P<0.05). Compared with the model group, the moxibustion group and 
   acupuncture group showed decreased loose stool rate(P<0.05), increased total 
   distance traveled and grid crossing numbers in the open field test(P<0.05), 
   increased pain threshold and distension threshold(P<0.05), increased SDANN and 
   PNN50 (P<0.05), and decreased levels of serum IL-6, IL-8, and TNF-α 
   contents(P<0.05). Compared with the acupuncture group, the moxibustion group 
   showed further decreased loose stool rate(P<0.05), increased total distance 
   traveled and grid crossing numbers in the open field test(P<0.05), increased pain 
   threshold and distension threshold(P<0.05), increased SDANN and PNN50(P<0.05), 
   and decreased levels of serum IL-6, IL-8, and TNF-α contents(P<0.05). No 
   significant pathological changes were observed in the colon tissue of rats in 
   each group. CONCLUSIONS: Moxibustion of combined "Biao-Ben" acupoints is more 
   effective in regulating HRV and serum IL-6, IL-8, and TNF-α contents in the IBS-D 
   rat model. Based on the combined "Biao-Ben" acupoints method, moxibustion has 
   better therapeutic effects on IBS-D than acupuncture.
C1 College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan 430061, China. 2814416550@qq.com.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan 430061, China. hwang.tcm@china.com.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan 430061, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan 430061, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan 430061, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan 430061, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan 430061, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan 430061, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD NOV 21
PY 2023
VL 48
IS 11
BP 1134
EP 1141
DI 10.13702/j.1000-0607.20230147 
PG 7
WC Rats; Female; Animals; Irritable Bowel Syndrome; therapy; Moxibustion; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; genetics; Interleukin-8; Interleukin-6; genetics; Acupuncture Points; Acupuncture Therapy; Diarrhea; therapy; Autonomic Nervous System
UT PubMed:37984911
PM 37984911
DA 2023-11-21
ER

PT J
AU Ruela, LO
   Iunes, DH
   Nogueira, DA
   Stefanello, J
   Gradim, CVC
AF Ruela, Ludmila de Oliveira
   Iunes, Denise Hollanda
   Nogueira, Denismar Alves
   Stefanello, Juliana
   Gradim, Clícia Valim Côrtes
TI Effectiveness of auricular acupuncture in the treatment of cancer pain: 
SO Revista da Escola de Enfermagem da U S P
LA spa
DT Journal Article
AB OBJECTIVE: To evaluate the effectiveness of auricular acupuncture in the pain of 
   cancer patients receiving chemotherapy and to verify if there were alterations in 
   the use of analgesics after the application of this intervention. METHOD: 
   Randomized controlled trial with cancer patients with complaints of pain greater 
   than or equal to four in the Numerical Pain Scale. Two parallel groups were 
   created, an Experimental group, which received auricular acupuncture at energy 
   balance points and at points indicated for the treatment of pain, and a Placebo 
   group, in which fixed placebo points were used. Both groups received the 
   application of semipermanent needles in eight sessions. RESULTS: 31 cancer 
   patients participated in the study. After the eight auricular acupuncture 
   sessions, there was a significant difference between the groups regarding the 
   reduction of pain intensity (p < 0.001) and of the use of medications (p < 0.05). 
   CONCLUSION: Auricular acupuncture was effective in reducing the pain of patients 
   receiving chemotherapy. Brazilian Registry of Clinical Trials: RBR-6k3rqh.
C1 Universidade Federal de Alfenas, Escola de Enfermagem, Alfenas, MG, Brasil.
   Universidade Federal de Alfenas, Instituto Ciências da Motricidade. Alfenas, MG, Brasil.
   Universidade Federal de Alfenas, Instituto de Ciências Exatas, Departamento de Estatística, Alfenas, MG, Brasil.
   Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto, Departamento Materno-Infantil e Saúde Pública, Ribeirão Preto, SP, Brasil.
   Universidade Federal de Alfenas, Escola de Enfermagem, Alfenas, MG, Brasil.
NR 0
TC 0
SN 
EI 0080-623
J9 Rev Esc Enferm USP
PD DEC 21
PY 2018
VL 52
IS 
BP e03402
EP e03402
DI 10.1590/S1980-220X2017040503402 
PG 1
WC Acupuncture, Ear; methods; Adult; Aged; Analgesics; administration & dosage; Antineoplastic Agents; administration & dosage; Brazil; Cancer Pain; therapy; Female; Humans; Male; Middle Aged; Neoplasms; drug therapy; Pain Measurement; Treatment Outcome
UT PubMed:30570087
PM 30570087
DA 2018-12-21
ER

PT J
AU Lyu, Z
   Tian, S
   Bao, G
   Huang, R
   Gong, L
   Zhou, J
   Kong, X
   Zhang, W
   Ran, R
   Nie, N
   Liu, Y
   Ji, C
   Liu, S
   Shao, X
   Kai, G
   Lin, X
   Fang, J
   Liang, Y
AF Lyu, Zhengyi
   Tian, Shuxin
   Bao, Guanai
   Huang, Rui
   Gong, Liyan
   Zhou, Jie
   Kong, Xiangming
   Zhang, Weiping
   Ran, Ran
   Nie, Na
   Liu, Yang
   Ji, Conghua
   Liu, Shan
   Shao, Xiaomei
   Kai, Guoyin
   Lin, Xianming
   Fang, Jianqiao
   Liang, Yi
TI Transcutaneous electrical acupoint stimulation for cancer-related pain management 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture,; Cancer-related pain,; Chronic opioid therapy,; Transcutaneous electrical acupoint stimulation,; Transcutaneous electrical nerve stimulation
AB PURPOSE: The opioid crisis resulting from its use disorder and overdose poses 
   additional challenges for cancer pain management. The American Society of 
   Clinical Oncology Practice Guideline recommends acupuncture therapy for the 
   management of adult cancer-related pain (CRP), but the effectiveness of 
   transcutaneous electrical acupoint stimulation (TEAS) on CRP remains uncertain. 
   METHODS: This 5-week prospective randomized clinical trial was conducted at 2 
   hospitals in China, and participants with CRP receiving chronic opioid therapy 
   were randomized 1:1 into two groups between December 2014 and June 2018. The true 
   TEAS group underwent 15 sessions of TEAS treatments over 3 consecutive weeks, 
   while the control group received sham stimulation. The primary outcome was the 
   numerical rating scale (NRS) score in the past 24h at week 3. The secondary 
   outcomes included morphine equivalent daily dose, quality of life and adverse 
   events. RESULTS: A total of 159 participants were included in the modified 
   intention-to-treat population. The baseline characteristics were similar in both 
   groups. The mean NRS scores were 0.98 points at week 3 in the true TEAS group and 
   1.41 points in the sham group, with the mean difference between groups of -0.43 
   points (P < 0.001; OR = 0.68, P < 0.05). The proportion of patients with NRS 
   reduction more than thirty percentage at week 3 was 50.00% in the true TEAS group 
   and 35.44% in the sham group (RD = 0.15, P > 0.05; RR = 1.41, P > 0.05). No 
   significant difference in pain intensity between the two groups was observed 
   during the follow-up period without TEAS intervention (week 4, OR = 0.83, 
   P > 0.05; week 5, OR = 0.83, P > 0.05). The Karnofsky Performance Status value 
   suggested that patients in the true TEAS group experienced an improved quality of 
   life (Between-group differences: week 3, 3.5%, P < 0.05; week 4, 4.6%, P < 0.001; 
   week 5, 5.6%, P < 0.001). CONCLUSIONS: The 3-week application of TEAS in patients 
   with CRP receiving chronic opioid therapy resulted in a statistically significant 
   reduction in pain scores, but the observed reduction was of uncertain clinical 
   significance. The prolonged analgesic effect of TEAS was not confirmed in this 
   trial. CLINICALTRIAL: GOV: ChiCTR-TRC-13003803.
C1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310005, China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310005, China.
   Department of Integrated Chinese Traditional Medicine and Western Medicine, Zhejiang Cancer Hospital, Hangzhou, 310022, China.
   Department of Acupuncture and Tuina, Wenzhou Central Hospital, Wenzhou, 325000, China.
   Department of Integrated Chinese Traditional Medicine and Western Medicine, Zhejiang Cancer Hospital, Hangzhou, 310022, China.
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China.
   Department of Integrated Chinese Traditional Medicine and Western Medicine, Zhejiang Cancer Hospital, Hangzhou, 310022, China.
   Department of Oncology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China.
   Department of Oncology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China.
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310005, China.
   Zhejiang Chinese Medical University, Hangzhou, 310005, China.
   Department of Clinical Evaluation Center, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, 310000, China.
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China.
   Zhejiang Chinese Medical University, Hangzhou, 310005, China.
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China.
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China. fangjianqiao7532@163.com.
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China. liangyiwww@126.com.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD DEC 12
PY 2023
VL 32
IS 1
BP 16
EP 16
DI 10.1007/s00520-023-08240-1 
PG 0
WC Adult; Humans; Acupuncture Points; Analgesics, Opioid; adverse effects; Cancer Pain; drug therapy; Morphine; Neoplasms; therapy; Pain Management; Prospective Studies; Quality of Life; Transcutaneous Electric Nerve Stimulation; methods
UT PubMed:38085376
PM 38085376
DA 2023-12-12
ER

PT J
AU Hou, W
   Pei, L
   Song, Y
   Wu, J
   Geng, H
   Chen, L
   Wang, Y
   Hu, Y
   Zhou, J
   Sun, J
AF Hou, Wenzhen
   Pei, Lixia
   Song, Yafang
   Wu, Jian
   Geng, Hao
   Chen, Lu
   Wang, Yuhang
   Hu, Yao
   Zhou, Jinyong
   Sun, Jianhua
TI Acupuncture therapy for breast cancer-related lymphedema: A systematic review and 
SO The journal of obstetrics and gynaecology research
LA English
DT Journal Article
DE acupuncture therapy; breast cancer-related lymphedema; meta-analysis
AB This study aimed to conduct a comprehensive analysis of clinical studies on 
   acupuncture treatment for breast cancer-related lymphedema (BCRL), so as to 
   explore the efficacy and safety of acupuncture treatment and provide evidence for 
   the clinical decision-making. Public databases, mainly including China Academic 
   Journals Full-text Database, Database of Chinese Sci-Tech Journal, Wanfang, 
   PubMed, Embase and the Cochrane Library, from the establishment of databases to 
   December 2018 were searched for randomized controlled trials (RCT) of acupuncture 
   for BCRL. Clinical RCT on the treatment of BCRL with acupuncture combined with 
   drugs or functional exercise were enrolled for the analysis. Bias risk and 
   quality were assessed by two investigators according to the Cochrane Handbook 
   5.1.0 standard, and the Revman 5.3 software was used for meta-analysis. A total 
   of 13 studies were enrolled, comprising 747 patients (377 in the treatment group 
   and 370 in the control group). The results of meta-analysis showed that 
   acupuncture intervention could improve the total effective rate for the treatment 
   of BCRL (odds ratio = 4.62; 95% confidence interval 2.61-8.17). Recent studies 
   suggest that acupuncture therapy can alleviate the upper limb swelling and 
   improve the subjective pain and discomfort in patients with BCRL, regardless of 
   the control intervention used. However, the number of high-quality RCT is low. 
   Moreover, most of the studies adopted inconsistent efficacy indicators. Hence, 
   additional blinded, large-sample, randomized, well-controlled studies with 
   objective and uniform efficacy indicators are needed, especially in China, to 
   confirm the findings.
C1 Department of Acupuncture, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Department of Acupuncture, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Department of Acupuncture and Manipulation, Nanjing University of Chinese Medicine, Nanjing, China.
   Department of Central Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Department of Acupuncture, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Department of Acupuncture, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Department of Acupuncture and Manipulation, Nanjing University of Chinese Medicine, Nanjing, China.
   Department of TCM, WUXI Higher Health Vocational Technology School, Wuxi, China.
   Department of Central Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Department of Acupuncture, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
NR 0
TC 0
SN 1447-075
EI 
J9 J Obstet Gynaecol Res
PD OCT 15
PY 2019
VL 45
IS 12
BP 2307
EP 2317
DI 10.1111/jog.14122 
PG 10
WC Acupuncture Therapy; adverse effects; Breast Neoplasms; complications; Female; Humans; Lymphedema; therapy; Quality Assurance, Health Care; Randomized Controlled Trials as Topic
UT PubMed:31608558
PM 31608558
DA 2019-10-15
ER

PT J
AU Ma, T
   Xue, G
   Zhang, J
   Qin, X
AF Ma, Taoye
   Xue, Guoqiang
   Zhang, Jie
   Qin, Xiaoyu
TI Effects of acupuncture on postoperative pain in patients undergoing breast cancer 
SO Asian journal of surgery
LA English
DT Letter
DE Acupuncture; Breast cancer surgery; Meta-analysis; Postoperative pain; Systematic review
C1 Gansu Province Central Hospital, Lanzhou, Gansu, 730070, China
   Gansu Provincial Maternal and Child Health Hospital, Lanzhou, Gansu, 730050, China.
   Department of Urology, The Second People's Hospital of Gansu Province, Lanzhou, Gansu, 730030, China
   Department of Urology, Affiliated Hospital of NorthwestMinzu University, Lanzhou, Gansu, 730030, China.
   Anesthesia and Pain Medical Center, Gansu Hospital of TCM, Lanzhou, Gansu, 730050, China.
   Department of Anesthesiology, Shanghai East Hospital, Shanghai, 200120, China. 
EM qxyznl@163.com
NR 0
TC 0
SN 0219-310
EI 
J9 Asian J Surg
PD JUN 22
PY 2023
VL 46
IS 11
BP 5029
EP 5031
DI 10.1016/j.asjsur.2023.06.060 
PG 2
WC Humans; Female; Breast Neoplasms; surgery; Acupuncture Therapy; Mastectomy; Pain, Postoperative
UT PubMed:37344321
PM 37344321
DA 2023-06-22
ER

PT J
AU Xu, D
   Yu, Z
   Cai, X
   Lin, J
   Lin, T
   Sun, J
   Liu, Z
   Cao, Y
   He, Y
AF Xu, Danghan
   Yu, Zhanbo
   Cai, Ximin
   Lin, Jietao
   Lin, Tengjiao
   Sun, Jian
   Liu, Zhaoxi
   Cao, Yang
   He, Yihan
TI Effect of Fu's subcutaneous needling for cancer pain management: protocol for a 
SO BMJ open
LA English
DT Journal Article
DE COMPLEMENTARY MEDICINE; Cancer pain; PAIN MANAGEMENT
AB INTRODUCTION: Pain is a common symptom in patients with cancer, and pain 
   management is crucial for these patients. Fu's subcutaneous needling (FSN) is a 
   modern acupuncture therapy based on basic medicine commonly used in patients with 
   pain. However, evidence of its effectiveness in treating cancer pain has not been 
   systematically proven. Therefore, this pragmatic randomised controlled trial aims 
   to evaluate the effectiveness and safety of FSN for cancer pain management. 
   METHODS AND ANALYSIS: Overall, 120 eligible patients will be recruited and 
   randomly assigned into two groups using block randomisation. Both groups will be 
   administered analgesic drugs according to the National Comprehensive Cancer 
   Network guidelines. The treatment group will receive FSN therapy one time a day 
   for 6 days. Additionally, we will assess analgesic consumption as the primary 
   outcome and the Numerical Rating Scale, outbreak pain, symptom assessment and 
   adverse events as secondary outcomes to evaluate the effect and safety of FSN in 
   treating cancer pain. The incidence of adverse events will be monitored to assess 
   the safety of FSN. ETHICS AND DISSEMINATION: Ethics approval was obtained from 
   the Ethics Committee of the First Affiliated Hospital of Guangzhou University of 
   Chinese Medicine (approval No: K(2021)096). The results will be published in a 
   peer-reviewed journal, and trial participants will be informed via email and/or 
   phone calls. TRIAL REGISTRATION NUMBER: ChiCTR2200056348.
C1 Rehabilitation Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Oncology Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Radiotherapy Department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Acupuncture Department, Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine),Guangdong Provincial Academy of Chinese Medical Science, Guangzhou, Guangdong,China.
   Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Oncology Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Oncology Department, Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine),Guangdong Provincial Academy of Chinese Medical Science, Guangzhou, Chinayihanhe@gzucm.edu.cn.
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD APR 28
PY 2023
VL 13
IS 4
BP e068232
EP e068232
DI 10.1136/bmjopen-2022-068232 
PG 1
WC Humans; Acupuncture Therapy; methods; Cancer Pain; therapy; Neoplasms; complications; Pain Management; methods; Subcutaneous Tissue; Treatment Outcome; Vascular Surgical Procedures; Pragmatic Clinical Trials as Topic
UT PubMed:37105691
PM 37105691
DA 2023-04-28
ER

PT J
AU Wu, X
   Chung, VC
   Hui, EP
   Ziea, ET
   Ng, BF
   Ho, RS
   Tsoi, KK
   Wong, SY
   Wu, JC
AF Wu, Xinyin
   Chung, Vincent C H
   Hui, Edwin P
   Ziea, Eric T C
   Ng, Bacon F L
   Ho, Robin S T
   Tsoi, Kelvin K F
   Wong, Samuel Y S
   Wu, Justin C Y
TI Effectiveness of acupuncture and related therapies for palliative care of cancer: 
SO Scientific reports
LA English
DT Journal Article
AB Acupuncture and related therapies such as moxibustion and transcutaneous 
   electrical nerve stimulation are often used to manage cancer-related symptoms, 
   but their effectiveness and safety are controversial. We conducted this overview 
   to summarise the evidence on acupuncture for palliative care of cancer. Our 
   systematic review synthesised the results from clinical trials of patients with 
   any type of cancer. The methodological quality of the 23 systematic reviews in 
   this overview, assessed using the Methodological Quality of Systematic Reviews 
   Instrument, was found to be satisfactory. There is evidence for the therapeutic 
   effects of acupuncture for the management of cancer-related fatigue, 
   chemotherapy-induced nausea and vomiting and leucopenia in patients with cancer. 
   There is conflicting evidence regarding the treatment of cancer-related pain, hot 
   flashes and hiccups, and improving patients' quality of life. The available 
   evidence is currently insufficient to support or refute the potential of 
   acupuncture and related therapies in the management of xerostomia, dyspnea and 
   lymphedema and in the improvement of psychological well-being. No serious adverse 
   effects were reported in any study. Because acupuncture appears to be relatively 
   safe, it could be considered as a complementary form of palliative care for 
   cancer, especially for clinical problems for which conventional care options are 
   limited.
C1 Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong.
   Jockey Club School of Public Health and Primary Care, The Chinese University of 
   Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong.
   Jockey Club School of Public Health and Primary Care, The Chinese University of 
   Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong.
   Comprehensive Cancer Trials Unit, The Chinese University of Hong Kong, Hong Kong.
   Chinese Medicine Department, Hong Kong Hospital Authority, Hong Kong.
   Chinese Medicine Department, Hong Kong Hospital Authority, Hong Kong.
   Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
   Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
   Big Data Decision Analytics Research Centre, The Chinese University of Hong Kong, 
   Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong.
   Jockey Club School of Public Health and Primary Care, The Chinese University of 
   Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong.
   Department of Medicine &Therapeutics, The Chinese University of Hong Kong, Hong 
NR 0
TC 0
SN 2045-232
EI 
J9 Sci Rep
PD NOV 27
PY 2015
VL 5
IS 
BP 16776
EP 16776
DI 10.1038/srep16776 
PG 0
WC Acupuncture Therapy; adverse effects; Dyspnea; etiology; Hiccup; etiology; Humans; Nausea; etiology; Neoplasms; complications; Palliative Care; Randomized Controlled Trials as Topic; Treatment Outcome; Vomiting; etiology; Xerostomia; etiology
UT PubMed:26608664
PM 26608664
DA 2015-11-27
ER

PT J
AU Ben-Arye, E
   Galil, G
   Samuels, N
   Segev, Y
   Schmidt, M
   Gressel, O
AF Ben-Arye, Eran
   Galil, Galit
   Samuels, Noah
   Segev, Yakir
   Schmidt, Meirav
   Gressel, Orit
TI Fine-tuning the needle: analysis of acupuncturist response to alarming events 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture; Gynecological oncology; Integrative medicine; Integrative oncology; Intraoperative; Pain
AB OBJECTIVE: Examining an intra-operative acupuncture/acupressure setting, with 
   real-time "fine-tuning" in response to alarming events (AEvs) during 
   gynecological oncology surgery. METHODS: Narratives of acupuncturists providing 
   intraoperative acupuncture during gynecological oncology surgery were 
   qualitatively analyzed. These described real time "fine-tuning" in response to 
   AEvs during surgery, identified through hemodynamic changes (e.g., 
   systolic/diastolic arterial pressure); bispectral index (BIS) elevation; and 
   feedback from surgeons and anesthesiologists. Documentation of acupuncturist 
   responses to AEvs was addressed as well. RESULTS: Of the 48 patients in the 
   cohort, 33 had at least one intraoperative AEv (69%), of which 30 were undergoing 
   laparoscopic surgery and 18 laparotomies. A total of 77 AEvs were documented 
   throughout surgery (range 1-7; mean: 2.3 events per patient), identified through 
   increased (63 events) or decreased (8) mean arterial pressure (MAP); increased 
   BIS levels (2), or other hemodynamic parameters (4). Integrative oncology 
   interventions implemented in response to AEs included acupressure alone (59); 
   combining acupressure with acupuncture (10); or acupuncture alone (4). In 54 
   (70%) events, documentation was provided from beginning to conclusion of the AEv, 
   with a mean duration of 9.7 min, with 32 events including a documented 
   anesthesiologist intervention. CONCLUSION: The present study demonstrated the 
   feasibility of intraoperative acupuncture with acupressure, with ongoing 
   "fine-tuning" to AEvs identified through objective pain-related parameters (MAP, 
   heart rate and BIS) and real-time input from surgeons and anesthesiologists. 
   Documentation of the intraoperative IO practitioner's response to these AEvs is 
   important, and should be addressed in future research of the innovative 
   integrative model of care. TRIAL REGISTRATION NUMBER: CMC-18-0037 (Carmel Medical 
   Center, June 11, 2018).
C1 Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, 35 Rothschild St., Haifa, Israel.eranben@netvision.net.il.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 
   Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, 35 Rothschild St., Haifa, Israel.
   Center for Integrative Complementary Medicine, Shaarei Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Unit of Gynecological Oncology, Department of Obstetrics and Gynecology, Carmel 
   Unit of Gynecological Oncology, Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
   Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, 35 Rothschild St., Haifa, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD MAY 13
PY 2024
VL 32
IS 6
BP 343
EP 343
DI 10.1007/s00520-024-08552-w 
PG 0
WC Humans; Female; Middle Aged; Gynecologic Surgical Procedures; methods; Genital Neoplasms, Female; surgery; Aged; Adult; Acupressure; methods; Laparoscopy; methods; Acupuncture Therapy; methods; Intraoperative Care; methods
UT PubMed:38739310
PM 38739310
DA 2024-05-13
ER

PT J
AU Cui, L
   Bai, Z
AF Cui, Leilei
   Bai, Zhaoliang
TI Effect of Moxibustion Instrument Combined with Intermediate Frequency 
SO Computational and mathematical methods in medicine
LA English
DT Journal Article
AB OBJECTIVE: To explore the effect of a moxibustion instrument combined with 
   intermediate frequency electrostatic therapy on pain and joint function in 
   elderly patients with cold-dampness arthritis (KOA). METHOD: 200 patients with 
   cold-dampness KOA treated in our hospital from May 2019 to September 2021 were 
   selected. According to the random number table method, they were divided into the 
   observation group (n = 100) and control group (n = 100). The observation group 
   was treated with moxibustion combined with medium-frequency treatment, and the 
   control group was treated with medium-frequency treatment. The clinical effects 
   of the two groups were compared. The joint functions of the two groups were 
   evaluated by the visualization scale of the osteoarthritis index (WOMAC index) of 
   McMaster University in Western Ontario. The TCM symptom scores of the two groups 
   were evaluated according to the guiding principles for clinical research of new 
   traditional Chinese medicine. The visual analogue scale (VAS) was used to 
   evaluate the pain degree of the two groups, and the microcirculatory blood 
   perfusion (MBPU) and interleukin-1 were compared between the two groups, β 
   (IL-1β) and tumor necrosis factor-α (TNF-α). The levels of matrix 
   metalloproteinase-1 (MMP-1), serum bone morphogenetic protein-2 (BMP-2), 
   cartilage oligomeric matrix protein (COMP), and serum type II collagen C-terminal 
   peptide (CTX-II) were assessed by the comprehensive quality of life 
   questionnaire-74. RESULT: The total effective rate of the observation group 
   (92.00%) was higher than that of the control group (76.00%), and the difference 
   was statistically significant (P < 0.05) in β and TNF-α. The levels of MMP-3, 
   BMP-2, comp, and CTX-II and the improvement of quality of life score in the 
   control group were better than those in the control group (P < 0.05). CONCLUSION: 
   Moxibustion instrument combined with intermediate frequency electrostatic therapy 
   can effectively improve the knee joint function, pain, blood perfusion, 
   inflammatory reaction, and cartilage damage of the elderly patients with 
   cold-dampness-type knee arthritis, and the therapeutic effect is good.
C1 The 971st Navy Hospital of the Chinese People's Liberation Army, The First Outpatients, Qingdao, Shandong 266071, China.
   Outpatient Department, 971st Hospital, People's Liberation Army Navy, Qingdao, Shandong 266071, China.
NR 0
TC 0
SN 1748-671
EI 1748-670
J9 Comput Math Methods Med
PD MAY 17
PY 2022
VL 2022
IS 
BP 2613901
EP 2613901
DI 10.1155/2022/2613901 
PG 0
WC Aged; Humans; Knee Joint; Microcirculation; Moxibustion; Osteoarthritis, Knee; therapy; Pain; etiology; Quality of Life; Static Electricity; Treatment Outcome; Tumor Necrosis Factor-alpha
UT PubMed:35572837
PM 35572837
DA 2022-05-17
ER

PT J
AU Li, G
   Zhang, C
   Wang, C
   Xiao, L
AF Li, Gang
   Zhang, Changxi
   Wang, Congyi
   Xiao, Ling
TI Acupuncture against chronic postsurgical pain in non-small cell lung cancer 
SO Medicine
LA English
DT Journal Article
AB INTRODUCTION: Video-assisted thoracoscopic lobectomy is the prior recommended 
   treatment for non-small cell lung cancer (NSCLC), with the advantages of small 
   trauma, less postoperative pain, and quick recovery. However, a large number of 
   patients may suffer chronic postsurgical pain (CPSP), which makes the patients 
   unwilling to practice pulmonary exercises, and it would directly affect patient's 
   cough, sputum expectoration, and mobility. Opioids could greatly improve the 
   quality of postoperative analgesia and the quality of life after surgery, but it 
   is accompanied with obvious side effects. A number of clinical studies have 
   proved that acupuncture could improve postoperative pain and reduce opioid use. 
   In this study, we try to conduct a randomized controlled study to evaluate the 
   efficacy and safety of plum-blossom needle acupuncture combined with Tramadol in 
   improving CPSP after lobectomy in NSCLC patients. METHODS: Patients will be 
   randomly divided into treatment group (acupuncture plus Tramadol) and control 
   group (sham acupuncture plus Tramadol) with a random number table in 1:1 ratio. 
   The patients, outcome assessor, and statistician will be blinded. The outcomes 
   are changes of numerical rating scale, Karnofsky performance score, brief pain 
   inventory, blood routine, liver and kidney function. The data will be analyzed by 
   SPSS 22.0. CONCLUSIONS: The results will help to evaluate the efficacy and safety 
   of plum-blossom needle acupuncture in improving CPSP after lobectomy in NSCLC 
   patients.
C1 Department of Thoracic Surgery, Chongqing Steel General Hospital, Dadukou District, Chongqing, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD OCT 9
PY 2021
VL 100
IS 40
BP e27461
EP e27461
DI 10.1097/MD.0000000000027461 
PG 1
WC Acupuncture Therapy; methods; Adult; Aged; Analgesics, Opioid; administration & dosage; Carcinoma, Non-Small-Cell Lung; surgery; Combined Modality Therapy; Female; Humans; Lung Neoplasms; surgery; Male; Middle Aged; Pain Measurement; Pain, Postoperative; drug therapy; Pneumonectomy; adverse effects; Research Design; Thoracic Surgery, Video-Assisted; adverse effects; Tramadol; administration & dosage; Randomized Controlled Trials as Topic
UT PubMed:34622872
PM 34622872
DA 2021-10-09
ER

PT J
AU Chen, H
   Liu, TY
   Kuai, L
   Zhu, J
   Wu, CJ
   Liu, LM
AF Chen, Hao
   Liu, Tang-Yi
   Kuai, Le
   Zhu, Ji
   Wu, Cai-Jun
   Liu, Lu-Ming
TI Electroacupuncture treatment for pancreatic cancer pain: a randomized controlled 
SO Pancreatology : official journal of the International Association of 
LA English
DT Journal Article
DE Electroacupuncture; Pain; Pancreatic cancer
AB BACKGROUND: Pancreatic cancer is often accompanied by severe abdominal or back 
   pain. It's the first study to evaluate the analgesic effect of electroacupuncture 
   on pancreatic cancer pain. A randomized controlled trial compared 
   electroacupuncture with control acupuncture using the placebo needle. METHODS: 
   Sixty patients with pancreatic cancer pain were randomly assigned to the 
   electroacupuncture group (n = 30) and the placebo control group (n = 30). 
   Patients were treated on Jiaji (Ex-B2) points T8-T12 bilaterally for 30 min once 
   a day for 3 days. Pain intensity was assessed with numerical rated scales (NRS) 
   before the treatment (Baseline), after 3 treatments, and 2 days follow-up. 
   RESULTS: Baseline characteristics were similar in the two groups. After 3 
   treatment, pain intensity on NRS decreased compared with Baseline (-1.67, 95% 
   confidence interval [CI] -1.46 to -1.87) in the electroacupuncture group; there 
   was little change (-0.13, 95% CI 0.08 to -0.35) in control group; the difference 
   between two groups was statistically significant (P < 0.001). Follow-up also 
   found a significant reduction in pain intensity in the electroacupuncture group 
   compared with the control group (P < 0.001). CONCLUSIONS: Electroacupuncture was 
   an effective treatment for relieving pancreatic cancer pain.
C1 Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
NR 0
TC 0
SN 1424-391
EI 
J9 Pancreatology
PD NOV 28
PY 2013
VL 13
IS 6
BP 594
EP 7
DI 10.1016/j.pan.2013.10.007 
PG -587
WC Adolescent; Adult; Aged; Analgesics; therapeutic use; Disease Progression; Electroacupuncture; methods; Female; Humans; Liver Neoplasms; secondary; Male; Middle Aged; Pain Management; Pain Measurement; Pain, Intractable; etiology; Pancreatic Neoplasms; complications; Survival Analysis; Young Adult
UT PubMed:24280575
PM 24280575
DA 2013-11-28
ER

PT J
AU Li, LL
   Jiang, X
   Wan, YX
   Qi, XW
   Huang, JC
AF Li, Li-Ling
   Jiang, Xin
   Wan, Yu-Xiang
   Qi, Xue-Wei
   Huang, Jin-Chang
TI [Exploration of the thinking and methods in treatment of cancer pain with 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture-moxibustion therapy; cancer pain; fascial network; jingjin; myofascial chain
AB There is a commonality between jingjin (muscle region of meridian) and the 
   fascial network for coordinating the balance in the body. The occurrence and the 
   progression of tumor may disrupt the overall coordination between the fascial 
   network and jingjin directly or indirectly, thereby, the impairment of this 
   coordination may result in cancer pain. Rooted on the theory of overall balance 
   of the fascial network, and combined with understanding of pain in jingjin 
   theory, professor HUANG Jin-chang emphasizes the importance of "relaxing the 
   knot" in treatment of cancer pain. It is recommended to select the fascia 
   reaction point as the target point, in accordance with the principle of balance 
   adjustment and apply various acupuncture and moxibustion therapies, such as Fu's 
   subcutaneous needling, small-needle scalpel therapy, fire needling, and 
   moxibustion.
C1 Third Affiliated Hospital of Beijing University of CM, Beijing 100029, China.
   Oncology Department of Acupuncture and Minimally Invasive Treatment, Third Affiliated Hospital of Beijing University of CM, Beijing 100029.
   Oncology Department of Acupuncture and Minimally Invasive Treatment, Third Affiliated Hospital of Beijing University of CM, Beijing 100029
   Institute ofAcupuncture and Oncology, Beijing University of CM, Beijing 100029.
   Third Affiliated Hospital of Beijing University of CM, Beijing 100029, China.
   Oncology Department of Acupuncture and Minimally Invasive Treatment, Third Affiliated Hospital of Beijing University of CM, Beijing 100029
   Institute ofAcupuncture and Oncology, Beijing University of CM, Beijing 100029.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD AUG 14
PY 2023
VL 43
IS 8
BP 894
EP 8
DI 10.13703/j.0255-2930.20230210-0004 
PG -886
WC Humans; Moxibustion; Cancer Pain; Acupuncture Points; Acupuncture Therapy; Fascia; Neoplasms; complications
UT PubMed:37577884
PM 37577884
DA 2023-08-14
ER

PT J
AU Relf, IRN
   Brahmanand, T
AF Relf, Ian R N
   Brahmanand, Tanishka
TI Reductions in Chronic Postsurgical Neuropathic Pain and Mechanical Allodynia in 
SO Clinical breast cancer
LA English
DT Journal Article
DE Breast cancer surgery (BCS); Chronic postsurgical pain; Embryology; Neuropathic pain; Static mechanical allodynia (SMA)
AB INTRODUCTION: Chronic postsurgical neuropathic pain (CPSNP) and related static 
   mechanical allodynia (SMA) is recognised as a significant long-term complication 
   after breast cancer surgery (BCS). This study investigates the effectiveness of a 
   novel laser acupuncture technique in treating CPSNP and SMA post-BCS whilst 
   patients underwent standard cancer treatments. METHODS: Thirty patients with 
   significant breast area CPSNP and SMA (DN4 ≥ 4) were treated with 60Milliwatt, 
   658nm laser acupuncture at Austin Hospital between January 2021 and 2024. Patient 
   data was analysed retrospectively: 29 with CPSNP, 22 with SMA. The cohort had 
   exposures to pain aggravating cancer therapies (e.g. chemotherapy, radiotherapy 
   and antihormonal medications). An online patient questionnaire assessed treatment 
   outcomes qualitatively. RESULTS: Patients received an average of 6·4 treatments 
   and their average CPSNP showed significant reduction from 6·86 to 1.29 (P < 
   .001), with a mean 5.57 point decrease (95% CI, 4.90-6.24). Average SMA showed 
   significant reduction from an average of 6.77-1.75 (P < .001), with a mean 
   5.02-point decrease (95% CI, 4.09-5.96). Pain reductions occurred despite NP 
   aggravating treatment and ongoing usage by 40% of the cohort. 92% of patients 
   reported acute reductions in SMA in the online questionnaire. CONCLUSION: The 
   significant pain reductions observed may indicate effectiveness of laser 
   acupuncture in reducing both CPSNP and SMA in breast cancer patients post-BCS.
C1 Olivia Newton John Cancer and Wellness Centre, Austin Hospital, Melbourne, Australia. 
   Department of Medicine, University of Melbourne, Austin Hospital Clinical School, Melbourne, Victoria, Australia.
EM Ian.RELF@austin.org.au
NR 0
TC 0
SN 1938-066
EI 
J9 Clin Breast Cancer
PD OCT 20
PY 2024
VL 24
IS 8
BP 763
EP 770
DI 10.1016/j.clbc.2024.09.005 
PG 7
WC Humans; Female; Breast Neoplasms; complications; Retrospective Studies; Neuralgia; etiology; Middle Aged; Pain, Postoperative; etiology; Acupuncture Therapy; methods; Aged; Hyperalgesia; etiology; Adult; Treatment Outcome; Mastectomy; adverse effects; Laser Therapy; methods
UT PubMed:39426907
PM 39426907
DA 2024-10-20
ER

PT J
AU Dymáčková, R
   Sláma, O
AF Dymáčková, R
   Sláma, O
TI [Acupuncture in the treatment of symptoms of oncological diseases in the Western 
SO Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti
LA cze
DT Journal Article
AB Acupuncture is one of the methods of traditional Chinese Medicine (TCM). In Asia, 
   methods of TCM are quite often used in oncological patients in combination with 
   classical medicine. In Europe and North America, the position of the TCM is not 
   so clear. In the last few years, some studies were done which were supposed to 
   verify scientifically the effectiveness of acupuncture in the treatment of some 
   symptoms in oncological patients and adverse effects of oncological treatment. 
   Results of these studies indicate that acupuncture is effective in the treatment 
   of pain, nausea, vomiting and xerostomia. The International Society of 
   Integrative Oncology formulated some recommendations for using methods of TCM in 
   oncological patients. In this field, there is still a lot of possibilities for 
   further studies which could help acupuncture to become an important therapeutic 
   method even in our region.
NR 0
TC 0
SN 
EI 0862-495
J9 Klin Onkol
PD AUG 15
PY 2014
VL 27
IS 4
BP 291
EP 3
DI 
PG -288
WC Acupuncture Therapy; Europe; Humans; Medicine, Chinese Traditional; Nausea; etiology; Neoplasms; complications; North America; Pain; etiology; Vomiting; etiology; Xerostomia; etiology
UT PubMed:25115720
PM 25115720
DA 2014-08-15
ER

PT J
AU Tofthagen, C
   Boses, S
   Healy, G
   Jooma, N
AF Tofthagen, Cindy
   Boses, Sarah
   Healy, Gene
   Jooma, Nuruddin
TI Evaluation of Group Acupuncture for Cancer-Related Symptoms: A Retrospective 
SO Journal of palliative medicine
LA English
DT Journal Article
AB BACKGROUND: Acupuncture is being used for treatment of cancer-related symptoms in 
   numerous settings, yet empirical evidence supporting the effects of acupuncture 
   in this setting is lacking. Group acupuncture is an economical way to provide 
   acupuncture to patients at a reduced cost. OBJECTIVE: In this retrospective study 
   we sought to evaluate the effects of group acupuncture on specific cancer-related 
   symptoms in persons receiving outpatient cancer treatment. METHODS: Patients were 
   receiving group acupuncture treatments through an integrative oncology program in 
   a large community oncology practice in west central Florida. A short 
   patient-completed assessment of seven basic cancer-related symptoms using a 0-10 
   numeric rating scale was completed at each acupuncture treatment. Basic 
   demographic information, including age, gender, race/ethnicity, and cancer type 
   was obtained from the medical record. Paired sample t-tests were used to evaluate 
   differences in symptoms before the first treatment and at the fourth treatment. 
   RESULTS: Fifty patients completed at least four weekly acupuncture treatments in 
   2014. Forty-three of them completed symptom assessments and were included in this 
   analysis. The mean age of participants was 66.4 years. The majority of patients 
   were white, non-Hispanic, and female. No significant improvement in symptoms were 
   identified at the third treatment. At the time of the fourth group acupuncture, 
   participants reported significantly less pain/numbness and problems with 
   digestion. DISCUSSION: The results of this study provide evidence to support the 
   efficacy of group acupuncture for pain, neuropathy, and digestive problems in 
   persons with cancer. A minimum of four weekly treatments may be necessary before 
   improvements are noted. Limitations include a retrospective design, incomplete 
   symptom evaluation, and possible response bias. Future studies of group 
   acupuncture for cancer-related symptoms should utilize a prospective, controlled 
   design, use validated measures to thoroughly evaluate targeted symptoms, and 
   include a more racially and ethnically diverse sample.
C1 1 College of Nursing, University of South Florida , Tampa, Florida.
   2 Integrative Oncology Department, Florida Cancer Specialists , Largo, Florida.
   3 Root Healing Acupuncture , Dunedin, Florida.
   2 Integrative Oncology Department, Florida Cancer Specialists , Largo, Florida.
NR 0
TC 0
SN 1557-774
EI 
J9 J Palliat Med
PD JUL 29
PY 2015
VL 18
IS 10
BP 878
EP 80
DI 10.1089/jpm.2015.0143 
PG -798
WC Acupuncture Therapy; economics; Adult; Aged; Aged, 80 and over; Ambulatory Care; economics; Digestive System Diseases; etiology; Female; Florida; Group Processes; Humans; Male; Middle Aged; Neoplasms; complications; Neuralgia; etiology; Pain Management; methods; Retrospective Studies
UT PubMed:26218367
PM 26218367
DA 2015-07-29
ER

PT J
AU Xu, LP
   Yang, SL
   Su, SQ
   Huang, BX
   Lan, XM
   Yao, RJ
AF Xu, Li-Ping
   Yang, Shi-Lai
   Su, Shao-Qing
   Huang, Bi-Xia
   Lan, Xin-Mei
   Yao, Ru-Jie
TI Effect of wrist-ankle acupuncture therapy combined with auricular acupuncture on 
SO Complementary therapies in clinical practice
LA English
DT Journal Article
DE Auricular acupuncture; Cancer pain; Combine therapy; Wrist-ankle acupuncture therapy
AB BACKGROUND: Cancer pain affects the quality of life of cancer patients; 
   therefore, various methods exist for alleviating the adverse effects caused by 
   cancer pain. Nonpharmacological intervention is regarded as an important means of 
   auxiliary therapy for drug treatment, with acupuncture receiving the most 
   attention; However, there are numerous types of acupuncture therapies, including 
   acupuncture, wrist-ankle acupuncture (WAA) and auricular acupuncture (AA). 
   Previous studies have demonstrated that all types of acupuncture therapy can 
   alleviate cancer pain. However, the effects and pathways of different acupuncture 
   treatments are not similar, and it is unknown whether single therapy or 
   combination therapy has better analgesic effects. This study aimed to examine the 
   effect of WAA therapy combined with AA on cancer pain. DESIGN: A randomized 
   controlled trial. METHOD: A total of 160 patients were selected and randomly 
   divided into groups A, B, C and D, with 40 patients in each group. Group A 
   received conventional analgesia alone, with opioids administered based on the 
   World Health Organization (WHO) 3-tiered "cancer pain ladder". Group B received 
   WAA, in addition to the treatment received by group A. Group C received AA, in 
   addition to the treatment received by group A. Group D received WAA combined with 
   AA, in addition to the treatment received by group A. Analgesic effects and 
   analgesic drug use before and 3, 5 and 7 days after treatment were observed in 
   each group. RESULT: A total of 159 patients were included in the analysis. The 
   verbal rating scale (VRS) and numeric rating scale (NRS) scores for patients who 
   received mono-acupuncture therapy and combination therapy for 1 week were 
   significantly different from those of the control group. Combination therapy had 
   a stronger effect on the VRS score and a faster onset time, based on the NRS 
   score, and the patients who received combination therapy had reduced analgesic 
   drug use. CONCLUSION: WAA combined with AA can more quickly reduce pain symptoms 
   with more lasting analgesic effects and can effectively reduce analgesic drug 
   use.
C1 Nursing Department, The Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China. 
   School of Nursing, Quanzhou Medical College, Quanzhou, China. 
   People's Hospital Affiliated of Fujian University of Traditional Chinese Medicine, Fuzhou, China.
   The Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China.
   The Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China.
   The Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China.
EM 247872083@qq.com
NR 0
TC 0
SN 1873-694
EI 
J9 Complement Ther Clin Pract
PD MAY 8
PY 2020
VL 39
IS 
BP 101170
EP 101170
DI 10.1016/j.ctcp.2020.101170 
PG 0
WC Acupuncture Therapy; methods; Acupuncture, Ear; methods; Adult; Aged; Aged, 80 and over; Analgesics; therapeutic use; Analgesics, Opioid; therapeutic use; Cancer Pain; drug therapy; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Pain Management; methods
UT PubMed:32379695
PM 32379695
DA 2020-05-08
ER

PT J
AU Segev, Y
   Abofol, S
   Samuels, N
   Schmidt, M
   Assaf, W
   Ben-Arye, E
AF Segev, Yakir
   Abofol, Sereen
   Samuels, Noah
   Schmidt, Meirav
   Assaf, Wisam
   Ben-Arye, Eran
TI Postoperative pain following intraoperative acupuncture: a randomized‑controlled 
SO BMJ supportive & palliative care
LA English
DT Journal Article
DE Integrative Oncology; Pain; Supportive care
AB CONTEXT AND OBJECTIVES: This study examined the impact of an integrative oncology 
   intervention on postoperative care, primarily postoperative pain, in patients 
   undergoing gynaecological oncology surgery. METHODS: Participants were randomised 
   to three groups: group A, preoperative touch/relaxation modalities, followed by 
   intraoperative acupuncture; group B, preoperative touch/relaxation only and group 
   C, standard conventional care alone. Using an enhanced recovery after surgery 
   (ERAS) protocol, medical personnel retrospectively assessed pain on each 
   postoperative day (POD), using a Visual Analogue Scale (VAS; 0, no pain; 10, most 
   severe pain). Use of analgesics, bowel movements, urination and number of days 
   until discharge were also assessed. RESULTS: A total of 102 patients 
   participated, with similar baseline demographic and surgery-related 
   characteristics among the three groups (group A, 45; group B, 25 and group C, 
   32). Group A patients undergoing laparoscopic surgery reported significantly 
   lower pain scores on POD1 than group C (p=0.018). Group B patients undergoing 
   open laparotomy were discharged earlier than group C (p=0.031). No significant 
   between-group differences were found for VAS pain scales, use of analgesics or 
   report of first postoperative bowel movement or urination. CONCLUSIONS: This 
   prospective, controlled and pragmatic ERAS-based study suggests that 
   intraoperative acupuncture may reduce postoperative pain on POD1, in patients 
   undergoing laparoscopic gynaecological oncology surgery. The findings differ from 
   a previous study which found no effect of acupuncture on pain-related 
   haemodynamic parameters during laparoscopy. Further research using objective 
   nociception parameters is needed to explore the effect of intraoperative 
   acupuncture on postoperative pain. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov 
   (NCT03560388).
C1 Division Of Gynecology Oncology at the obsterics and Gynecology department, carmel medical center, Haifa, Israel segevyakir@yahoo.com.
   Obstetrics and Gynecology Department, Carmel Medical Center, Haifa, Israel.
   Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
   Division Of Gynecology Oncology at the obsterics and Gynecology department, carmel medical center, Haifa, Israel.
   Division Of Gynecology Oncology at the obsterics and Gynecology department, carmel medical center, Haifa, Israel.
   LIN Medical Center, Haifa, Israel.
   Clalit Health Services, Tel Aviv-Yafo, Israel.
NR 0
TC 0
SN 2045-436
EI 
J9 BMJ Support Palliat Care
PD JUN 20
PY 2025
VL 15
IS 5
BP 642
EP 647
DI 10.1136/spcare-2025-005485 
PG 5
WC Humans; Female; Pain, Postoperative; therapy; Middle Aged; Acupuncture Therapy; methods; Adult; Pain Measurement; Aged; Prospective Studies; Intraoperative Care; methods; Gynecologic Surgical Procedures; adverse effects
UT PubMed:40537176
PM 40537176
DA 2025-06-20
ER

PT J
AU Chen, Y
   Li, M
   Guo, K
AF Chen, Yuwei
   Li, Mingzhu
   Guo, Kaixin
TI Exploring the mechanisms and current status of acupuncture in alleviating tumor 
SO SLAS technology
LA English
DT Journal Article
DE Acupuncture; Central nervous system; Endocrine System; Immune microenvironment; Tumor metabolism; Tumor-related diseases
AB Acupuncture, as a traditional Chinese medical treatment, has garnered increasing 
   attention in recent years in fields such as tumor metabolism, the central nervous 
   system, and the immune microenvironment. This paper aims to explore the 
   fundamental principles, mechanisms, and research status of acupuncture therapy 
   for tumor-related diseases. Firstly, we introduce the basic principles of 
   acupuncture therapy, including the theories of meridians and its theoretical 
   basis in tumor treatment. Secondly, we systematically review the mechanisms of 
   acupuncture therapy for tumor-related diseases, discussing how acupuncture 
   alleviates side effects such as pain, depression, fatigue, and gastrointestinal 
   discomfort caused by conventional treatments through modulation of the immune 
   microenvironment, central nervous system, and endocrine system. Subsequently, we 
   discuss the current research status of acupuncture therapy for tumor-related 
   diseases, as well as the application of current research methods and technologies 
   in elucidating acupuncture mechanisms. Additionally, by combining clinical 
   practice with different types of tumor-related diseases as experimental subjects, 
   we demonstrate the application effectiveness and clinical practice experience of 
   acupuncture in tumor treatment. Finally, a comprehensive assessment of 
   acupuncture therapy for tumor-related diseases is provided, summarizing its 
   limitations and prospecting future directions, including interdisciplinary 
   collaboration and personalized treatment. In conclusion, acupuncture, as a 
   feasible adjunctive therapy, is closely related to the central nervous system and 
   the immune microenvironment, holding potential significant value in tumor 
   treatment.
C1 First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250000, China. 
   First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250000, China. 
   Department of Acupuncture, Shandong University of Traditional Chinese Medicine, Jinan 250000, China. 
EM 17860505418@163.com
NR 0
TC 0
SN 2472-631
EI 
J9 SLAS Technol
PD OCT 14
PY 2024
VL 29
IS 6
BP 100208
EP 100208
DI 10.1016/j.slast.2024.100208 
PG 0
WC Humans; Acupuncture Therapy; methods; Central Nervous System; immunology; Neoplasms; therapy; Tumor Microenvironment
UT PubMed:39396727
PM 39396727
DA 2024-10-14
ER

PT J
AU Romeo, MJ
   Parton, B
   Russo, RA
   Hays, LS
   Conboy, L
AF Romeo, Melissa J
   Parton, Barbara
   Russo, Rachel A
   Hays, Lewis S
   Conboy, Lisa
TI Acupuncture to Treat the Symptoms of Patients in a Palliative Care Setting.
SO Explore (New York, N.Y.)
LA English
DT Journal Article
DE acupuncture; anxiety; hospice; pain; palliative; well-being
AB INTRODUCTION: Patients enrolled in hospice and palliative care programs 
   experience a vast array of symptoms requiring the expertise of a 
   multidisciplinary team to address. Acupuncture can be an effective addition to a 
   hospice team whose goal is maximum comfort and quality of life (QOL). The 
   objective of this project was to examine the effectiveness of acupuncture to 
   relieve symptoms commonly observed in patients in a hospice program. METHODS: All 
   over 26 patients participated in the acupuncture trial, receiving a course of 
   weekly treatments that ranged from 1 to 14 weeks. The average number of 
   treatments was five. The Edmonton Symptom Assessment Scale (ESAS) was used to 
   assess the severity of pain, tiredness, nausea, depression, anxiety, drowsiness, 
   appetite, well-being, and dyspnea. A two-tailed, paired t test was applied to the 
   data to compare symptom scores pre- versus post-acupuncture treatment. 
   SETTINGS/PARTICIPANTS: Patients enrolled in All Care Hospice's home care program 
   were given the option to receive acupuncture to supplement usual care offered by 
   the hospice team. Treatment was provided by licensed acupuncturists in the 
   patient's place of residence. RESULTS: Seven out of nine symptoms were 
   significantly (P < .001) improved with acupuncture, the exceptions being 
   drowsiness and appetite. Although the ESAS scale demonstrated a reduction in 
   symptom severity post-treatment for both drowsiness and appetite, this reduction 
   was not found to be significant. CONCLUSION: Acupuncture was found to be 
   effective for the reduction and relief of symptoms that commonly affect patient 
   QOL. Acupuncture effectively reduced symptoms of pain, tiredness, nausea, 
   depression, anxiety, and shortness of breath, and enhanced feelings of 
   well-being. More research is required to assess the long-term benefits and 
   symptom reduction of acupuncture in a palliative care setting.
C1 New England School of Acupuncture, 150 California St., Newton, MA 02458. 
   New England School of Acupuncture, 150 California St., Newton, MA 02458
   All Care Hospice, Lynn, MA
   Tufts Medical Center, Boston, MA.
   All Care Hospice, Lynn, MA.
   All Care Hospice, Lynn, MA
   Tufts University School of Medicine, Boston, MA.
   New England School of Acupuncture, 150 California St., Newton, MA 02458
   Beth Israel Deaconess Medical Center, Boston, MA.
EM mromeo@nesa.edu
NR 0
TC 0
SN 1878-754
EI 
J9 Explore (NY)
PD AUG 9
PY 2015
VL 11
IS 5
BP 357
EP 62
DI 10.1016/j.explore.2015.06.001 
PG -295
WC Acupuncture Therapy; Anxiety; etiology; Appetite; Depression; etiology; Dyspnea; etiology; Fatigue; etiology; Hospices; Humans; Nausea; etiology; Neoplasms; complications; Pain; etiology; Pain Management; Palliative Care; Quality of Life; Severity of Illness Index
UT PubMed:26254221
PM 26254221
DA 2015-08-09
ER

PT J
AU Lin, JG
   Chen, YH
AF Lin, Jaung-Geng
   Chen, Yi-Hung
TI The role of acupuncture in cancer supportive care.
SO The American journal of Chinese medicine
LA English
DT Review
AB Acupuncture has many beneficial effects during cancer therapy and has proven 
   efficacy in the management of side effects induced by chemotherapy and 
   radiotherapy. In this review, we discussed the benefits of acupuncture on cancer 
   patients. In cancer pain management, acupuncture is effective for head and neck 
   pain, waist pain, abdominal and chest pain. Many studies confirm the excellent 
   efficacy of acupuncture against symptoms of vomiting and nausea, including those 
   induced by chemotherapy and radiotherapy. Head and neck cancer patients receiving 
   radiotherapy may develop xerostomia, which may be relieved by acupuncture. 
   Acupuncture may also cause sedative and hypnotic effects in cancer patients for 
   treating nervousness and insomnia.
C1 School of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung, Taiwan. jglin@mail.cmu.edu.tw
NR 0
TC 0
SN 1793-685
EI 
J9 Am J Chin Med
PD MAR 16
PY 2012
VL 40
IS 2
BP 219
EP 29
DI 10.1142/S0192415X12500176 
PG -190
WC Acupuncture Therapy; Animals; Antineoplastic Agents; adverse effects; Humans; Neoplasms; complications; Radiotherapy; adverse effects
UT PubMed:22419418
PM 22419418
DA 2012-03-16
ER

PT J
AU Smith, CA
   Carmady, B
AF Smith, Caroline A
   Carmady, Bridget
TI Acupuncture to treat common reproductive health complaints: An overview of the 
SO Autonomic neuroscience : basic & clinical
LA English
DT Journal Article
AB BACKGROUND: Women specific health complaints are common, and women are higher 
   users of complementary therapies and medicines. Acupuncture is one modality used 
   by women. The aim of this paper was to summarise the evidence from scientific 
   trials and systematic reviews assessing the effectiveness of acupuncture to treat 
   the most common women specific reproductive health complaints. METHODS: We 
   conducted a search of the major databases PubMed, CINAHL, and the Cochrane 
   Library from their inception to Sept 2009, to obtain English language texts of 
   randomised controlled trials (RCTs) and systematic reviews. The following English 
   Australian search terms were used: acupuncture and period pain or dysmenorrhea, 
   or premenstrual syndrome, or poly cystic ovarian syndrome/PCOS, or menstrual 
   headache, or irregular periods/menstruation, or amenorrhea, or heavy 
   menses/periods, or menorrhagia, or menopause, and randomised controlled trial and 
   systematic review. Both authors extracted data and reviewed each trial and 
   systematic review for methodological quality. RESULTS: Five systematic reviews 
   were included, and six RCTs. The symptoms of the menopause and dysmenorrhea have 
   been subject to greater clinical evaluation through RCTs, and the evidence 
   summarised in systematic reviews, than any other reproductive health complaint. 
   The evidence for acupuncture to treat dysmenorrhea and menopause remains unclear, 
   due to small study populations and the presence of methodological bias. 
   Acupuncture to treat PMS, PCOS and other menstrual related symptoms is 
   under-studied, and the evidence for acupuncture to treat these conditions is 
   frequently based on single studies. CONCLUSION: Further research is needed.
C1 Centre for Complementary Medicine Research, The University of Western Sydney, Locked Bag 1797, Penrith South, NSW 1797, Australia. caroline.smith@uws.edu.au
NR 0
TC 0
SN 1872-748
EI 
J9 Auton Neurosci
PD MAY 21
PY 2010
VL 157
IS 1-2
BP 52
EP 6
DI 10.1016/j.autneu.2010.03.013 
PG -46
WC Acupuncture Therapy; methods; Databases, Factual; statistics & numerical data; Dysmenorrhea; therapy; Female; Humans; Polycystic Ovary Syndrome; therapy; Premenstrual Syndrome; therapy; Randomized Controlled Trials as Topic
UT PubMed:20483671
PM 20483671
DA 2010-05-21
ER

PT J
AU Cheung, DST
   Yeung, WF
   Chau, PH
   Lam, TC
   Yang, M
   Lai, K
   Ip, CY
   Lao, L
   Lin, CC
AF Cheung, Denise Shuk Ting
   Yeung, Wing Fai
   Chau, Pui Hing
   Lam, Tai Chung
   Yang, Mingxiao
   Lai, Kithelia
   Ip, Chun Yat
   Lao, Lixing
   Lin, Chia-Chin
TI Patient-centred, self-administered acupressure for Chinese advanced cancer 
SO European journal of cancer care
LA English
DT Journal Article
DE acupressure; advanced cancer; fatigue; insomnia; pain; traditional Chinese medicine
AB OBJECTIVES: To evaluate the feasibility and potential effects of patient-centred 
   self-administered acupressure for alleviating fatigue and co-occurring symptoms 
   among Chinese advanced cancer patients receiving treatment. METHODS: Thirty 
   advanced cancer patients who screened positive for moderate/severe fatigue with 
   symptoms of insomnia and/or pain were recruited from a hospital in Hong Kong. 
   They were randomly assigned (1:1) to receive a 4-week patient-centred 
   self-administered acupressure intervention or health education. Fatigue (primary 
   outcome) and secondary outcomes (sleep quality, pain, fatigue-sleep 
   disturbance-pain symptom cluster severity, anxiety, depression and quality of 
   life) were measured by questionnaires and actigraphy. RESULTS: Twenty-four 
   participants (80%) completed the study. Adherence to self-administered 
   acupressure practice was satisfactory, with all retained participants attending 
   all sessions and 90.9% practising acupressure daily. All completers rated the 
   class as very enjoyable or quite enjoyable. Fatigue, pain, symptom cluster 
   severity, anxiety, depression and quality of life appeared to improve from 
   baseline to post-intervention in the intervention group. Among these outcomes, 
   only the between-group difference in anxiety post-intervention was significant. 
   The group × time interaction effect was nonsignificant for all outcomes. 
   CONCLUSIONS: Patient-centred self-administered acupressure appears to be feasible 
   and acceptable among advanced cancer patients. A fully powered trial is warranted 
   to confirm the intervention effect.
C1 School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China.
   School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, China.
   Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, China.
   School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   Virginia University of Integrative Medicine, Virginia, United States.
   School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   Alice Ho Miu Ling Nethersole Charity Foundation Professor in Nursing, Hong Kong, 
   School of Nursing, College of Nursing, Taipei Medical University, Taiwan.
NR 0
TC 0
SN 1365-235
EI 
J9 Eur J Cancer Care (Engl)
PD SEP 9
PY 2020
VL 31
IS 5
BP e13314
EP e13314
DI 10.1111/ecc.13314 
PG 1
WC Acupressure; China; Fatigue; etiology; Humans; Neoplasms; complications; Pain; Pilot Projects; Quality of Life; Syndrome
UT PubMed:32896014
PM 32896014
DA 2020-09-09
ER

PT J
AU Gavronsky, S
   Koeniger-Donohue, R
   Steller, J
   Hawkins, JW
AF Gavronsky, Stas
   Koeniger-Donohue, Rebecca
   Steller, Julie
   Hawkins, Joellen W
TI Postoperative pain: acupuncture versus percutaneous electrical nerve stimulation.
SO Pain management nursing : official journal of the American Society of Pain 
LA English
DT Journal Article
AB The purpose of this study was to examine the effect of traditional acupuncture 
   compared with acupuncture with percutaneous electrical nerve stimulation (PENS) 
   on postoperative surgical pain relief in gynecologic oncology patients. Twenty 
   postoperative gynecologic oncology patients were randomly assigned into the two 
   groups, and the intervention was initiated within 24 hours after surgery. The 
   patients in each group received four treatments in the subsequent 48 hours, with 
   12 hours between each treatment. Either traditional acupuncture needles or 
   acupuncture needles with a pulsed electric current were applied to stimulate the 
   area of points Sp6 and Sp8 near the saphenous nerve. Pain measurement instruments 
   included a visual analog scale and the McGill Pain Questionnaire. Although the 
   PENS treatment group demonstrated a consistent decrease in pain with each 
   treatment application compared with the traditional acupuncture group, after 48 
   hours both groups experienced equivalent pain relief.
C1 School for Health Sciences, Simmons College, Boston, Massachusetts 02115, USA.
NR 0
TC 0
SN 1532-863
EI 
J9 Pain Manag Nurs
PD AUG 30
PY 2012
VL 13
IS 3
BP 150
EP 6
DI 10.1016/j.pmn.2009.08.001 
PG -144
WC Acupuncture Analgesia; methods; Adult; Aged; Aged, 80 and over; Female; Gynecologic Surgical Procedures; nursing; Humans; Middle Aged; Pain Measurement; Pain, Postoperative; nursing; Perioperative Nursing; methods; Transcutaneous Electric Nerve Stimulation; methods; Treatment Outcome
UT PubMed:22929602
PM 22929602
DA 2012-08-30
ER

PT J
AU Molassiotis, A
   Dawkins, B
   Longo, R
   Suen, LK
   Cheng, HL
   Mok, T
   Hulme, CT
   Yeo, W
AF Molassiotis, Alex
   Dawkins, Bryony
   Longo, Roberta
   Suen, Lorna Kp
   Cheng, Hui Lin
   Mok, Tony
   Hulme, Claire T
   Yeo, Winnie
TI Economic evaluation alongside a randomised controlled trial to assess the 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE acupuncture; chemotherapy; cost-effectiveness; peripheral neuropathy
AB OBJECTIVE: To assess the cost-effectiveness of acupuncture in the management of 
   chemotherapy-induced peripheral neuropathy (CIPN) in Hong Kong. METHODS: A within 
   trial cost-utility analysis with the primary endpoint for the economic evaluation 
   being the Quality Adjusted Life Year (QALY) and associated Incremental Cost 
   Effectiveness Ratio (ICER) over 14 weeks of treatment. A secondary 
   cost-effectiveness analysis was undertaken with the endpoint being change in pain 
   as measured on the Brief Pain Inventory (BPI). RESULTS: Eighty-seven patients 
   were randomised to acupuncture or usual care. Acupuncture resulted in significant 
   improvements in pain intensity (8- and 14-week mean changes compared to usual 
   care of -1.8 and -1.8, respectively), pain interference (8- and 14-week mean 
   changes compared to usual care of -1.5 and -0.9, respectively) and indicators of 
   quality of life and neurotoxicity-related symptoms. However, in the economic 
   evaluation there was little difference in QALYs between the two arms (mean change 
   0.209 and 0.200 in the acupuncture and usual care arms, respectively). Also, 
   costs yielded deterministic ICERs of HK$616,965.62, HK$824,083.44 and 
   HK$540,727.56 per QALY gained from the health care provider perspective, the 
   societal perspective and the patient perspective, respectively. These costs are 
   significantly higher than the cost-effectiveness threshold of HK$180,450 that was 
   used for the base case analysis. CONCLUSION: While acupuncture can improve 
   symptoms and quality of life indicators related to CIPN, it is unlikely to be a 
   cost-effective treatment for CIPN-related pain in health care systems with 
   limited resources. TRIAL REGISTRATION NUMBER: NCT02553863 (ClinicalTrials.gov) 
   post-results.
C1 School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR.
   Academic Unit of Health Economics, Leeds Institute of Health Sciences, University of Leeds, Leeds, UK.
   Academic Unit of Health Economics, Leeds Institute of Health Sciences, University of Leeds, Leeds, UK.
   School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR.
   School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR.
   Department of Clinical Oncology, Prince of Wales Hospital, Hung Hom, Hong Kong SAR.
   Academic Unit of Health Economics, Leeds Institute of Health Sciences, University of Leeds, Leeds, UK.
   Department of Clinical Oncology, Prince of Wales Hospital, Hung Hom, Hong Kong SAR.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD MAY 15
PY 2020
VL 39
IS 1
BP 41
EP 52
DI 10.1177/0964528420920285 
PG 11
WC Acupuncture Therapy; economics; Adult; Antineoplastic Agents; adverse effects; Cost-Benefit Analysis; Female; Hong Kong; Humans; Male; Middle Aged; Neoplasms; complications; Neuralgia; economics; Peripheral Nervous System Diseases; economics; Quality-Adjusted Life Years; Treatment Outcome
UT PubMed:32404001
PM 32404001
DA 2020-05-15
ER

PT J
AU Kuang, R
   Xiong, G
   Lv, W
   Zhao, Y
   Yu, M
   Jiang, J
AF Kuang, Renqing
   Xiong, Guojiang
   Lv, Wei
   Zhao, Yun
   Yu, Min
   Jiang, Jiawang
TI Efficacy and safety of acupuncture combined with analgesics on lung cancer pain: 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Lung cancer (LC) is the malignant tumor with the highest incidence in 
   the world, and treatment methods include surgery, radiotherapy, chemotherapy, and 
   immunotherapy. Cancer pain is a common symptom in patients with LC, and the 
   clinical treatment is to relieve it with analgesics. Acupuncture can relieve 
   cancer pain. This study aims to systematically study the efficacy and safety of 
   acupuncture combined with analgesics on cancer pain in patients with LC. METHODS: 
   From the beginning to April 2021, search Medline, Embase, Cochrane Central 
   Controlled Trials Register (Central), China National Knowledge Infrastructure 
   (CNKI), Wanfang Database, China Biomedical Literature Database (CBM), and Chinese 
   Science Journal Database (VIP database). Search the international clinical trial 
   registration platform and the Chinese clinical trial registration platform to 
   find ongoing or unpublished trials. The main outcome indicator is the total 
   effective rate of analgesia, and the secondary outcome indicator is pain 
   intensity score and adverse reactions. The RevMan 5.4 software will be used for 
   statistical analysis. RESULTS: This study will provide the latest evidence for 
   acupuncture combined with analgesics to relieve LC pain. CONCLUSION: The 
   conclusion of this study is to evaluate the effectiveness and safety of 
   acupuncture combined with analgesics in alleviating LC pain. INPLASY REGISTRATION 
   NUMBER: INPLASY202150051.
C1 Jiangxi University of Chinese Medicine.
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China.
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China.
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China.
   Jiangxi University of Chinese Medicine.
   Jiangxi University of Chinese Medicine.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JUN 12
PY 2021
VL 100
IS 23
BP e26225
EP e26225
DI 10.1097/MD.0000000000026225 
PG 1
WC Acupuncture Therapy; methods; Analgesics; standards; Cancer Pain; drug therapy; Clinical Protocols; Combined Modality Therapy; methods; Humans; Lung Neoplasms; complications; Pain Management; methods; Patient Safety; standards; Treatment Outcome
UT PubMed:34115008
PM 34115008
DA 2021-06-12
ER

PT J
AU Xu, L
   Wan, Y
   Huang, J
   Xu, F
AF Xu, Lili
   Wan, Yongxian
   Huang, Juan
   Xu, Fangyuan
TI Clinical analysis of electroacupuncture and multiple acupoint stimulation in 
SO Journal of cancer research and therapeutics
LA English
DT Journal Article
DE Cancerous pain; electroacupuncture; hepatocellular carcinoma; multiple acupoint stimulation; pain relief
AB OBJECTIVE: The objective of this study is to investigate the clinical efficacy 
   and safety of electroacupuncture and multiple acupoint stimulation in relieving 
   cancer pain in patients with advanced hepatocellular carcinoma. METHODS: 
   Sixty-five cases of advanced hepatocellular carcinoma with cancer pain were 
   selected in our hospital and were divided into electroacupuncture multiple 
   acupoint stimulation group (electroacupuncture group) (n = 32) and fentanyl 
   transdermal patch analgesia group (control group) (n = 33) according to analgesic 
   methods and intentions. In the electroacupuncture group, electric acupuncture 
   treatment was administered at different acupoints, including Baihui, Quchi, 
   Neiguan, Xuehai, Zusanli, and Sanyinjiao acupoint, once a day for 7 days. In the 
   control group, a fentanyl transdermal patch was placed on the upper left arm 
   every 3 days and replaced with a continuous external paste once for 7 days. Pain 
   scores in the two groups before and during the treatment were evaluated with a 
   visual analog scale (VAS), and adverse reactions during the treatment were 
   recorded. RESULTS: The VAS pain score of the electroacupuncture group was 
   significantly decreased on day 3 (P < 0.05), but the pain scores were not 
   significantly different (P > 0.05) between the two groups 4 days after treatment. 
   For treatment-related side effects, there were 3 cases of subcutaneous hemorrhage 
   in the electroacupuncture group; 1 case of skin rashes and 3 cases of nausea and 
   vomiting in the control group. The incidences of adverse reactions in the two 
   groups were 9.4% and 12.1%, respectively, without significant difference (P > 
   0.05). CONCLUSION: Cancer pain in patients with advanced hepatocellular carcinoma 
   can be alleviated with electroacupuncture and multiple acupoint stimulation, but 
   the onset pain relief was slow. To improve the analgesic effects of this 
   technique, the combination of various analgesic methods should be necessary in 
   early stage of the treatment.
C1 Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, PR China.
   Department of Bone and Joint Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, PR China.
   Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, PR China.
   Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, PR China.
NR 0
TC 0
SN 1998-413
EI 
J9 J Cancer Res Ther
PD MAR 9
PY 2018
VL 14
IS 1
BP 99
EP 102
DI 10.4103/jcrt.JCRT_736_17 
PG 3
WC Acupuncture Points; Aged; Cancer Pain; diagnosis; Carcinoma, Hepatocellular; complications; Electroacupuncture; adverse effects; Female; Humans; Liver Neoplasms; complications; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Pain Management; Pain Measurement; Treatment Outcome
UT PubMed:29516968
PM 29516968
DA 2018-03-09
ER

PT J
AU Zhang, DT
   Shi, GX
   Jia, JY
   Tan, FW
   Qi, Y
   Liang, W
   Zhao, ZJ
   Yuan, P
   Gao, Y
   Zhang, GC
   Liu, XH
   Yang, JW
   Wang, LQ
   Wang, X
   Yang, NN
   Tu, JF
   Liu, CZ
AF Zhang, Dan-Tong
   Shi, Guang-Xia
   Jia, Jin-Ying
   Tan, Feng-Wei
   Qi, Yu
   Liang, Wei
   Zhao, Zhi-Jun
   Yuan, Ping
   Gao, Ya
   Zhang, Guo-Chao
   Liu, Xue-Hui
   Yang, Jing-Wen
   Wang, Li-Qiong
   Wang, Xiao
   Yang, Na-Na
   Tu, Jian-Feng
   Liu, Cun-Zhi
TI Electroacupuncture for acute postoperative pain during coughing after 
SO PloS one
LA English
DT Journal Article
AB BACKGROUND: Despite the use of multimodal analgesia regimens following 
   video-assisted thoracoscopic surgery (VATS), acute postoperative pain persists. 
   Electroacupuncture (EA) may alleviate acute postoperative pain following VATS; 
   however, current evidence remains insufficient. OBJECTIVES: This trial will 
   assess the feasibility and efficacy of EA as an adjunctive treatment compared 
   with sham electroacupuncture (SA) for managing acute postoperative pain during 
   coughing after VATS. STUDY DESIGN AND METHODS: In this pilot randomized 
   controlled trial, 60 patients with non-small-cell lung cancer who will undergo 
   VATS will be randomly assigned to either the EA or SA group in a 1:1 ratio. 
   Patients will receive standard care combined with four sessions of EA or SA 
   within 72 h after surgery. The primary outcome will be the average postoperative 
   pain score during coughing, measured using a numeric rating scale within 72 h 
   after surgery. Secondary outcomes will include the average daily pain scores at 
   rest, during coughing, and while mobilizing; incidence of chronic post-surgical 
   pain; quality of life; cough symptom score; and analgesic consumption. All 
   adverse events will be recorded in detail. DISCUSSION: This study will determine 
   whether EA as an adjunctive treatment can reduce acute postoperative pain during 
   coughing following VATS. TRIAL REGISTRATION: ClinicalTrial.gov ITMCTR2024000170 
   (http://itmctr.ccebtcm.org.cn/zh-CN/Home/ProjectView?pid=f1a344f7-7e06-4665-ad9d-0917d588eba6).
C1 International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
   Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and PekingUnion Medical College, Beijing, China.
   The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
   The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
   The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
   The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
   The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
   Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and PekingUnion Medical College, Beijing, China.
   Medical College, Tianjin University, Tianjin, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
NR 0
TC 0
SN 1932-620
EI 
J9 PLoS One
PD MAR 27
PY 2025
VL 20
IS 3
BP e0316698
EP e0316698
DI 10.1371/journal.pone.0316698 
PG 1
WC Adult; Aged; Female; Humans; Male; Middle Aged; Carcinoma, Non-Small-Cell Lung; surgery; Cough; complications; Electroacupuncture; methods; Lung Neoplasms; surgery; Pain, Postoperative; therapy; Pilot Projects; Quality of Life; Thoracic Surgery, Video-Assisted; adverse effects; Randomized Controlled Trials as Topic
UT PubMed:40138259
PM 40138259
DA 2025-03-27
ER

PT J
AU Garcia, MK
   Cohen, L
   Spano, M
   Spelman, A
   Hashmi, Y
   Chaoul, A
   Wei, Q
   Lopez, G
AF Garcia, M Kay
   Cohen, Lorenzo
   Spano, Michael
   Spelman, Amy
   Hashmi, Yousra
   Chaoul, Alejandro
   Wei, Qi
   Lopez, Gabriel
TI Inpatient Acupuncture at a Major Cancer Center.
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; cancer; inpatient; integrative medicine; oncology
AB BACKGROUND: Use of complementary and integrative therapies is increasing among 
   cancer patients, but data regarding the impact treatments such as acupuncture 
   have in an inpatient oncology setting are limited. METHODS: Patients who received 
   acupuncture in an inpatient hospital environment between December 2014 and 
   December 2015 were asked to complete a modified Edmonton Symptom Assessment Scale 
   (ESAS; 0-10 scale) before and after each visit. Pre- and post-treatment scores 
   were examined for each symptom using paired t tests. RESULTS: A total of 172 
   inpatients were treated with acupuncture in their hospital beds (257 visits). 
   Thirty percent (n = 51) received at least one additional follow-up treatment 
   (mean visits/patient = 1.5). Completion rate of the modified ESAS after 
   acupuncture was 42%. The most common reasons for not completing the 
   post-treatment ESAS were "patient too drowsy" or "patient fell asleep" (72%). For 
   patients who reported a baseline symptom score ≥1, the greatest improvements 
   (mean change ± SD) after acupuncture on the initial visit were found for pain 
   (-1.8 ± 2.2; n = 69; P < .0001), nausea (-1.2 ± 1.9; n = 30; P < .001), anxiety 
   (-0.8 ± 1.8; n = 36; P = .01), drowsiness (-0.6 ± 1.8; n = 57; P = .02), and 
   fatigue (-0.4 ± 1.1; n = 67; P = .008). For patients who received at least one 
   follow-up visit, significant improvement from baseline was found for sleep 
   disturbance (-2.5 ± 4.4; n = 17; P = .03), anxiety (-2.4 ± 1.7; n = 9; P = .002), 
   pain (-2.3 ± 2.7; n = 20; P = .001), and drowsiness (-2.0 ± 2.6; n = 16; P = 
   .008). CONCLUSIONS: Patients who received inpatient acupuncture at a major cancer 
   center experienced significant improvement after treatment for pain, sleep 
   disturbance, anxiety, drowsiness, nausea, and fatigue.
C1 1 The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
   1 The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
   1 The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
   1 The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
   1 The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
   1 The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
   1 The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
   1 The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD JAN 5
PY 2017
VL 17
IS 1
BP 148
EP 152
DI 10.1177/1534735416685403 
PG 4
WC Acupuncture Therapy; Adolescent; Adult; Aged; Aged, 80 and over; Female; Hospitalization; Humans; Male; Middle Aged; Neoplasms; complications; Young Adult
UT PubMed:28050924
PM 28050924
DA 2017-01-05
ER

PT J
AU Zhu, ZX
   Chen, C
   Zheng, YF
   Gong, WL
   Chen, Z
   Fang, SL
   Shao, DH
   Sun, CX
AF Zhu, Zhi-Xin
   Chen, Chen
   Zheng, Yong-Feng
   Gong, Wei-Li
   Chen, Zheng
   Fang, Shi-Lei
   Shao, Dong-Hua
   Sun, Cai-Xia
TI Buccal Acupuncture Alleviates Postoperative Pain in Patients Undergoing Radical 
SO Chinese journal of integrative medicine
LA English
DT Journal Article
DE Chinese medicine; acupuncture analgesia; buccal acupuncture; gastrointestinal cancers; postoperative pain; recovery quality
AB OBJECTIVE: To preliminarily investigate the effect of buccal acupuncture therapy 
   on ameliorating postoperative pain and enhancing recovery quality among patients 
   undergoing radical resection of gastrointestinal cancers. METHODS: Fifty-two 
   participants were randomized at a 1:1 ratio to either the buccal acupuncture or 
   the control group. The acupuncture protocol entailed targeting 5 predetermined 
   acupoints [CA-2 (Upper jiao), CA-3 (Middle jiao), CA-4 (Lower jiao), CA-6 (back), 
   and CA-7 (waist) and two adjustable acupoints [CA-1 (head) and CA-8 (sacrum)] on 
   each side of the face. The outcomes included the Numeric Rating Scale (NRS) 
   scores for each day within 7 days postoperatively, 15-Item Quality of Recovery 
   Scale (QoR-15) scores, analgesics consumption during and after surgery, 
   incidences of postoperative nausea and vomiting, and perioperative levels of 
   interleukin-6 and glucose. Adverse events related to acupuncture were recorded. 
   RESULTS: Of the initial 52 participants, 46 completed the study and were included 
   in the analysis. Findings indicated that the buccal acupuncture group experienced 
   significantly reduced resting NRS scores in post-anesthesia care unit and 
   throughout the postoperative phase (P=0.001 and P=0.003, respectively), along 
   with enhanced QoR-15 scores on the 3rd postoperative day (P=0.008), compared to 
   the control group. No notable differences were identified in the remaining 
   indicators (P>0.05). CONCLUSION: Buccal acupuncture therapy demonstrated 
   significant effectiveness in reducing postoperative pain and improving recovery 
   quality for patients undergoing radical resection of gastrointestinal cancers, 
   presenting a viable intervention without associated adverse outcomes. (Trial 
   registration No. ChiCTR2200060441).
C1 Department of Anesthesiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, 212002, China.
   Department of Anesthesiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, 212002, China.
   Department of Anesthesiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, 212002, China.
   Department of Acupuncture and Moxibustion, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, 212002, China.
   Department of Anesthesiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, 212002, China.
   Department of Anesthesiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, 212002, China.
   Department of Anesthesiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, 212002, China.
   Department of Anesthesiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, 212002, China. suncaixia_zj@126.com.
NR 0
TC 0
SN 1993-040
EI 
J9 Chin J Integr Med
PD MAR 14
PY 2025
VL 31
IS 6
BP 558
EP 565
DI 10.1007/s11655-025-4128-y 
PG 7
WC Humans; Male; Pilot Projects; Female; Acupuncture Therapy; methods; Pain, Postoperative; therapy; Middle Aged; Gastrointestinal Neoplasms; surgery; Aged; Acupuncture Points; Adult
UT PubMed:40080251
PM 40080251
DA 2025-03-14
ER

PT J
AU Xu, M
   Fei, Y
   He, Q
   Fu, J
   Zhu, J
   Tao, J
   Ni, C
   Xu, C
   Zhou, Q
   Yao, M
   Ni, H
AF Xu, Miao
   Fei, Yong
   He, Qiuli
   Fu, Jie
   Zhu, Jianjun
   Tao, Jiachun
   Ni, Chaobo
   Xu, Chengfei
   Zhou, Qinghe
   Yao, Ming
   Ni, Huadong
TI Electroacupuncture Attenuates Cancer-Induced Bone Pain via NF-κB/CXCL12 Signaling 
SO ACS chemical neuroscience
LA English
DT Journal Article
DE CXCL12; Electroacupuncture; NF-κB; PAG; cancer-induced bone pain
AB Electroacupuncture (EA) is effective in various chronic pains. NF-κB and CXCL12 
   modulate the formation of chronic pain. Herein, we hypothesized that EA 
   alleviates cancer-induced bone pain (CIBP) through NF-κB/CXCL12 axis in midbrain 
   periaqueductal gray (PAG), which participates in "top-down" pain modulatory 
   circuits. In order to filter the optimum EA frequency for CIBP treatment, 2, 100, 
   or 2/100 Hz EA was set up. In addition, ipsilateral, contralateral, and bilateral 
   EA groups were established to affirm the optimal EA scheme. Bilateral 2/100 Hz EA 
   was considered as the optimal therapeutic scheme and was applied in a subsequent 
   experiment. Western blotting along with immunofluorescence illustrated that CIBP 
   induces a rapid and substantial increase in CXCL12 protein level and NF-κB 
   phosphorylation in vlPAG from day 6 to day 12. Anti-CXCL12 neutralizing antibody 
   and pAAV-U6-shRNA(CXCL12)-CMV-EGFP-WPRE in vlPAG remarkably improved the 
   mechanical pain threshold of the hind paw in CIBP model relative to the control. 
   EA inhibited the upregulation of pNF-κB and CXCL12 in vlPAG of CIBP. The 
   recombinant CXCL12 and pAAV-CMV-CXCL12-EF1a-EGFP-3Xflag-WPRE reversed the 
   abirritation of EA in the CIBP rat model. NF-κB phosphorylation mediated-CXCL12 
   expression contributed to CIBP allodynia, whereas EA suppressed NF-κB 
   phosphorylation in CIBP. According to the above evidence, we conclude that 
   bilateral 2/100 Hz EA is an optimal therapeutic scheme for CIBP. The abirritation 
   mechanism of EA might reduce the expression of CXCL12 by inhibiting the 
   activation of NF-κB, which might lead to the restraint of descending facilitation 
   of CIBP.
C1 Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing 314001, China.
   Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing 314001, China.
   Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing 314001, China.
   Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing 314001, China.
   Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing 314001, China.
   Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing 314001, China.
   Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing 314001, China.
   Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing 314001, China.
   Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing 314001, China.
   Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing 314001, China.
   Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, 1882 Zhonghuan South Road, Jiaxing 314001, China.
NR 0
TC 0
SN 1948-719
EI 
J9 ACS Chem Neurosci
PD AUG 31
PY 2021
VL 12
IS 18
BP 3323
EP 3334
DI 10.1021/acschemneuro.1c00224 
PG 11
WC Animals; Electroacupuncture; NF-kappa B; metabolism; Neoplasms; Pain Threshold; Periaqueductal Gray; metabolism; Rats; Rats, Sprague-Dawley
UT PubMed:34460214
PM 34460214
DA 2021-08-31
ER

PT J
AU Anand, K
   Niravath, P
AF Anand, Kartik
   Niravath, Polly
TI Acupuncture and Vitamin D for the Management of Aromatase Inhibitor-Induced 
SO Current oncology reports
LA English
DT Review
DE Acupuncture; Aromatase inhibitor; Arthralgia; Breast cancer; Breast cancer survivors; Quality of life; Vitamin D
AB PURPOSE OF REVIEW: Aromatase inhibitor-induced arthralgia (AIA) is a very common 
   syndrome which significantly affects breast cancer survivors' quality of life, 
   and it often leads to non-compliance with aromatase inhibitor (AI) therapy. 
   However, the treatment of AIA remains a clinical challenge. Here, we will review 
   the current data for acupuncture and vitamin D in the management of AIA. RECENT 
   FINDINGS: Acupuncture has been shown to improve AIA symptoms, but it has not 
   consistently been proven to offer significantly more clinical benefit than sham 
   acupuncture. Similarly, while some vitamin D trials have shown benefit, the 
   studies have not consistently shown improvement in AIA symptoms. Neither 
   acupuncture nor vitamin D can be touted as standard treatments for AIA. However, 
   many patients do experience subjective improvement of their symptoms with these 
   therapies. When other treatments, such as exercise and duloxetine, are not 
   feasible or not effective, it is reasonable to offer a trial of acupuncture or 
   vitamin D to patients who are suffering from AIA, as the potential harms are very 
   few, and they do offer possible relief from AIA symptoms.
C1 Houston Methodist Cancer Center/Weill Cornell Medicine, Outpatient Tower, Floor 24, 6445 Main Street, Houston, TX, 77030, USA.
   Houston Methodist Cancer Center/Weill Cornell Medicine, Outpatient Tower, Floor 24, 6445 Main Street, Houston, TX, 77030, USA. paniravath@houstonmethodist.org.
NR 0
TC 0
SN 1534-626
EI 
J9 Curr Oncol Rep
PD APR 19
PY 2019
VL 21
IS 6
BP 51
EP 51
DI 10.1007/s11912-019-0795-1 
PG 0
WC Acupuncture Therapy; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Cancer Survivors; Female; Humans; Quality of Life; Treatment Outcome; Vitamin D; therapeutic use
UT PubMed:30997616
PM 30997616
DA 2019-04-19
ER

PT J
AU Zhang, J
   Yang, M
   So, TH
   Chang, TY
   Qin, Z
   Chen, H
   Lam, WL
   Yeung, WF
   Chung, KF
   Jiang, F
   Lao, L
   Zhang, ZJ
AF Zhang, Jialing
   Yang, Mingxiao
   So, Tsz Him
   Chang, Tien Yee
   Qin, Zongshi
   Chen, Haiyong
   Lam, Wing Lok
   Yeung, Wing Fai
   Chung, Ka Fai
   Jiang, Fei
   Lao, Lixing
   Zhang, Zhang-Jin
TI Electroacupuncture Plus Auricular Acupressure on Chemotherapy-Related Insomnia in 
SO Integrative cancer therapies
LA English
DT Journal Article
DE auricular acupressure; breast cancer; chemotherapy; electroacupuncture; insomnia; sham control
AB OBJECTIVE: Insomnia is a highly prevalent and disturbing symptom in breast cancer 
   patients under or post chemotherapy. If not appropriately treated, it can persist 
   for years after the completion of cancer treatments. Acupuncture has been widely 
   used for alleviating insomnia. The aim of this study is to examine the 
   feasibility, efficacy and safety of acupuncture for chemotherapy-related insomnia 
   among patients with breast cancer. MATERIALS AND METHODS: This is a trial 
   protocol for a randomized, sham-controlled, subject- and assessor-blinded 
   clinical trial. A total of 138 eligible participants will be assigned randomly to 
   acupuncture or sham control group at a ratio of 1:1. Participants in acupuncture 
   group will receive electroacupuncture (EA) plus auricular acupressure (AA) 
   treatment, while subjects in sham acupuncture group will receive sham EA plus 
   sham AA. Both acupuncture and sham treatments will be given twice weekly for 
   6 weeks, followed by maintenance treatments once every 4 weeks for 12 weeks (15 
   sessions totally). The primary outcome is the change of Insomnia Severity Index 
   score between baseline and the end of 6-week treatment. Secondary outcome 
   measurements include Actiwatch, sleep diary, Pittsburgh Sleep Quality Index, 
   Functional Assessment of Cancer Therapy-Breast Cancer, Hospital Anxiety and 
   Depression Scale, Brief Pain Inventory-Short Form, Brief Fatigue Inventory, 
   Acupuncture Expectancy Scale, credibility, and adverse events. Participants will 
   be followed up to 42 weeks. CONCLUSIONS: This trial will expand our understanding 
   of the feasibility, efficacy, and safety of acupuncture as a treatment for 
   alleviating chemotherapy-related insomnia in patients with breast cancer. EA plus 
   AA, if proven to be effective, can be implemented into routine settings to play a 
   role in insomnia management for patients with breast cancer.
C1 Department of Chinese Medicine, The University of Hong Kong-Shenzhen Hospital (HKU-SZH), Shenzhen, Guangdong, China.
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   Department of Clinical Oncology, Hong Kong Sanatorium Hospital, Hong Kong, China.
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China.
   Department of Psychiatry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   Department of Statistics and Actuarial Science, The University of Hong Kong, Hong Kong, China.
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   Virginia University of Integrative Medicine, Fairfax, Virginia, USA.
   Department of Chinese Medicine, The University of Hong Kong-Shenzhen Hospital (HKU-SZH), Shenzhen, Guangdong, China.
   School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD NOV 23
PY 2021
VL 20
IS 
BP 15347354211058695
EP 15347354211058695
DI 10.1177/15347354211058695 
PG 1
WC Acupressure; Acupuncture Therapy; Breast Neoplasms; drug therapy; Electroacupuncture; Female; Humans; Randomized Controlled Trials as Topic; Sleep Initiation and Maintenance Disorders; chemically induced; Sleep Quality; Treatment Outcome
UT PubMed:34802291
PM 34802291
DA 2021-11-23
ER

PT J
AU Kim, TH
   Kang, JW
AF Kim, Tae-Hun
   Kang, Jung Won
TI Acupuncture for symptoms management in Korean breast cancer survivors: a 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE Korea; acupuncture; aromatase inhibitor–related arthralgia; breast cancer survivor; hot flushes; insomnia; post-mastectomy pain; sexual dysfunction
AB BACKGROUND: There is an unmet need for effective treatment of the various 
   treatment-related symptoms experienced by breast cancer survivors. These symptoms 
   could be alleviated by acupuncture. Although several lines of evidence in Western 
   countries suggest that acupuncture has a beneficial effect on symptoms in breast 
   cancer survivors, few relevant studies have been conducted in Korean patients. 
   This pilot study assessed the feasibility of acupuncture for a variety of 
   treatment-related symptoms in Korean breast cancer survivors. METHOD: From 
   October 2015 to March 2016, we recruited patients who had undergone treatment for 
   breast cancer and subsequently reported symptoms, including aromatase 
   inhibitor-related knee pain, vasomotor symptoms, insomnia, sexual dysfunction and 
   post-mastectomy pain in the chest wall or shoulder. The women received 4 weeks of 
   symptom-specific acupuncture followed by a further 4 weeks of follow-up to 
   evaluate the feasibility of acupuncture for this indication, and its impact on 
   common and symptom-specific outcome variables. RESULTS: Eight study participants 
   were recruited over a period of 6 months, six of whom completed the planned 
   acupuncture treatment and follow-up assessments. A total of 78 acupuncture 
   sessions were performed. We found that acupuncture was feasible, with only six 
   minor self-limiting acupuncture-related adverse events. Most of the women felt 
   that they had benefitted from participation in the study. The preliminary 
   analysis indicated improvement in common symptom-specific outcomes. CONCLUSION: 
   Our findings suggest that acupuncture is feasible, but low recruitment rates 
   should be considered when considering future acupuncture research in Korean 
   breast cancer survivors. Rigorous evaluation of this symptomatic treatment 
   strategy is now needed in the Korean population.
C1 1 Korean Medicine Clinical Trial Center, Korean Medicine Hospital, Kyung Hee University, Seoul, South Korea.
   2 Department of Acupuncture & Moxibustion, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD MAR 22
PY 2019
VL 37
IS 3
BP 164
EP 174
DI 10.1177/0964528419832610 
PG 10
WC Acupuncture Therapy; Adult; Aged; Antineoplastic Agents; adverse effects; Breast Neoplasms; complications; Female; Humans; Mastectomy; adverse effects; Middle Aged; Neuralgia; etiology; Pilot Projects; Prospective Studies; Radiotherapy; adverse effects; Republic of Korea; Survivors; statistics & numerical data; Treatment Outcome
UT PubMed:30896247
PM 30896247
DA 2019-03-22
ER

PT J
AU Tang, CJ
   Rong, Z
   Yang, MN
   Hong, XH
   Wang, TB
AF Tang, Cui-Juan
   Rong, Zhen
   Yang, Meng-Na
   Hong, Xiao-Hua
   Wang, Tong-Biao
TI [Rule of acupoint selection for cancer pain based on association rule and entropy 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture; association rules; cancer pain; entropy clustering; rules of acupoint selection
AB OBJECTIVE: To analyze the rule of acupoint selection for cancer pain based on 
   data mining. METHODS: The published literature regarding acupuncture for cancer 
   pain in the recent 10 years was searched in PubMed, CNKI, VIP and Wanfang 
   database. The acupoint selection was summarized and analyzed by TCMISS V2.5. 
   RESULTS: Totally 68 literature was collected and 73 acupoint prescriptions were 
   included, involving 117 acupoints. These acupoints were mainly in bladder 
   meridian, stomach meridian, liver meridian and spleen meridian. Among them, 40 
   acupoints used more than 4 times were identified, and the top three acupoints 
   were Zusanli (ST 36, 65 times), Neiguan (PC 6, 55 times) and Taichong (LR 3, 50 
   times). A total of 68 acupoint combinations used more than 19 times were 
   identified, and the top three acupoint combinations were Zusanli (ST 36)-Neiguan 
   (PC 6), Taichong (LR 3)-Zusanli (ST 36) and Zusanli (ST 36)-Sanyinjiao (SP 6). 
   There were 103 acupoint combinations with strong association; based on the 
   entropy clustering algorithm, 20 new acupoint combinations and 10 new acupoint 
   prescriptions were obtained. CONCLUSION: The main meridians for cancer pain are 
   bladder meridian, stomach meridian, liver meridian and spleen meridian, with 
   Zusanli (ST 36), Neiguan (PC 6), Taichong (LR 3), Hegu (LI 4), Sanyinjiao (SP 6) 
   and ashi points as core acupoints, and regulating spleen-stomach and treating 
   qi-blood are the main principles.
C1 Graduate School of Guangxi University of CM, Nanning 530200, China.
   First Affiliated Hospital of Guangxi University of CM, Nanning 530000.
   Graduate School of Guangxi University of CM, Nanning 530200, China.
   Graduate School of Guangxi University of CM, Nanning 530200, China.
   First Affiliated Hospital of Guangxi University of CM, Nanning 530000.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD APR 10
PY 2020
VL 40
IS 3
BP 331
EP 6
DI 10.13703/j.0255-2930.20190311-0001 
PG -325
WC Acupuncture Points; Acupuncture Therapy; Cancer Pain; therapy; Cluster Analysis; Entropy; Humans; Meridians; Neoplasms; physiopathology
UT PubMed:32270652
PM 32270652
DA 2020-04-10
ER

PT J
AU Chen, L
   Lin, CC
   Huang, TW
   Kuan, YC
   Huang, YH
   Chen, HC
   Kao, CY
   Su, CM
   Tam, KW
AF Chen, Lawrence
   Lin, Chao-Chun
   Huang, Tsai-Wei
   Kuan, Yi-Chun
   Huang, Yao-Hsien
   Chen, Hung-Chou
   Kao, Chun-Yu
   Su, Chih-Ming
   Tam, Ka-Wai
TI Effect of acupuncture on aromatase inhibitor-induced arthralgia in patients with 
SO Breast (Edinburgh, Scotland)
LA English
DT Review
DE Acupuncture; Aromatase inhibitor-induced arthralgia; Breast cancer; Meta-analysis
AB PURPOSE: Aromatase inhibitor (AI)-induced arthralgia (AIA) is a common side 
   effect that may lead to premature discontinuation of effective hormonal therapy 
   in patients with breast cancer. Acupuncture may relieve joint pain in patients 
   with AIA. We conducted a meta-analysis of randomized controlled trials (RCTs) to 
   evaluate the effectiveness of acupuncture in pain relief in AIA. METHODS: The 
   PubMed, Embase, Cochrane Library, and Scopus databases and the ClinicalTrials.gov 
   registry were searched for studies published before February 2017. Individual 
   effect sizes were standardized, and a meta-analysis was conducted to calculate 
   the pooled effect size by using a random effect model. Pain was assessed using 
   the Brief Pain Inventory (BPI) and Western Ontario and McMaster Universities 
   Osteoarthritis Index (WOMAC) at 3-4, 6-8, and 12 weeks. Secondary outcomes 
   included disability level, upper extremity function, physical performance, and 
   quality of life. RESULTS: Five trials involving 181 patients were reviewed. 
   Significant pain reduction was observed after 6-8 weeks of acupuncture treatment. 
   Patients receiving acupuncture showed a significant decrease in the BPI worst 
   pain score (weighted mean difference [WMD]: -3.81, 95% confidence interval 
   [CI]: -5.15 to -2.47) and the WOMAC pain score (WMD: -130.77, 95% CI: -230.31 
   to -31.22) after 6-8 weeks of treatment. One of the 4 trials reported 18 minor 
   adverse events in 8 patients during 398 intervention episodes. CONCLUSION: 
   Acupuncture is a safe and viable nonpharmacologic treatment that may relieve 
   joint pain in patients with AIA. Additional studies involving a higher number of 
   RCTs are warranted.
C1 Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
   Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
   Department of Nursing, College of Medicine and Nursing, HungKuang University, Taichung, Taiwan.
   Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
   Department of Neurology, School of Medicine, Taipei MedicalUniversity, Taipei, Taiwan.
   Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
   Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
   Department of Physical Medicine andRehabilitation, Shuang Ho Hospital, Taipei Medical University, New Taipei City,Taiwan
   Department of Physical Medicine and Rehabilitation, School of Medicine,College of Medicine, Taipei Medical University, Taipei, Taiwan.
   Division of Pediatric Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
   Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
   Division of General Surgery,Department of Surgery, School of Medicine, College of Medicine, Taipei MedicalUniversity, Taipei, Taiwan.
   Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
   Division of General Surgery, Department ofSurgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan;Division of General Surgery, Department of Surgery, School of Medicine, Collegeof Medicine, Taipei Medical University, Taipei, Taiwan
   Cochrane Taiwan, TaipeiMedical University, Taipei, Taiwan. 
EM kelvintam@h.tmu.edu.tw
NR 0
TC 0
SN 1532-308
EI 
J9 Breast
PD APR 7
PY 2017
VL 33
IS 
BP 132
EP 138
DI 10.1016/j.breast.2017.03.015 
PG 6
WC Acupuncture Therapy; methods; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; adverse effects; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Female; Humans; Middle Aged; Pain Measurement; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:28384564
PM 28384564
DA 2017-04-07
ER

PT J
AU Ji, JF
   Ge, XX
   Xu, CM
   Jiang, Y
   Gu, JH
   Wei, GH
   Gu, JS
   Shi, YJ
   Ni, XJ
AF Ji, Jin-Feng
   Ge, Xiao-Xia
   Xu, Chun-Ming
   Jiang, Yang
   Gu, Jun-Hong
   Wei, Guo-Hua
   Gu, Ji-Shu
   Shi, Yong-Jie
   Ni, Xue-Jiao
TI [Intradermal needling combined with heat-sensitive moxibustion for moderate to 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE cancer pain; heat-sensitive moxibustion; intradermal needling; three-step analgesic method
AB OBJECTIVE: To observe the effect of intradermal needling combined with 
   heat-sensitive moxibustion for moderate to severe cancer pain. METHODS: A total 
   of 60 patients with moderate to severe cancer pain were randomly divided into an 
   observation group and a control group，30 cases in each one. In the control 
   group，opioids were taken to relief pain according to the three-step analgesic 
   method of World Health Organization. On the base of the treatment as the control 
   group, intradermal needling combined with heat-sensitive moxibustion were applied 
   at Neiguan (PC 6), Hegu (LI 4), Zusanli (ST 36), Taichong (LR 3), etc. in the 
   observation group, 14 days of treatment were required. The equivalent morphine 
   consumption at the first day and whole course, the scores of cancer quality of 
   life questionnaire-C30 (QLQ-C30) and Hamilton anxiety scale before and after 
   treatment, and the adverse reaction rate were compared in the two groups. The 
   total analgesic effective rate was evaluated. RESULTS: The total analgesic 
   effective rate was 93.3% (28/30) in the observation group, higher than 73.3% 
   (22/30) in the control group (P<0.05). The total equivalent morphine consumption 
   in the observation group was less than the control group (P<0.05). After 
   treatment, the QLQ-C30 scores were increased (P<0.001) and the HAMA scores were 
   decreased (P<0.001) in the both groups, and those in the observation group were 
   superior to the control group (P<0.001). The adverse reaction rates of fatigue, 
   dizziness, nausea and vomiting, constipation in the observation group were lower 
   than the control group (P<0.05). CONCLUSION: Intradermal needling combined with 
   heat-sensitive moxibustion can reduce the dose of opioids, improve the quality of 
   life, relief the anxiety in patients with moderate to severe cancer pain, and 
   reduce the incidence of common adverse reaction of opioids.
C1 Department of Oncology of Integrated Chinese and Western Medicine, Jiangsu Tumor Hospital Affiliated to Nantong University, Nantong 226001, China.
   Department of Oncology, Jiangsu Tumor Hospital Affiliated to Nantong University, Nantong 226001, China.
   Department of Oncology of Integrated Chinese and Western Medicine, Jiangsu Tumor Hospital Affiliated to Nantong University, Nantong 226001, China.
   Department of Acupuncture and Moxibustion, Jiangsu Tumor Hospital Affiliated to Nantong University, Nantong 226001, China.
   Department of Oncology, Jiangsu Tumor Hospital Affiliated to Nantong University, Nantong 226001, China.
   Department of Oncology of Integrated Chinese and Western Medicine, Jiangsu Tumor Hospital Affiliated to Nantong University, Nantong 226001, China.
   Department of Oncology of Integrated Chinese and Western Medicine, Jiangsu Tumor Hospital Affiliated to Nantong University, Nantong 226001, China.
   Department of Oncology of Integrated Chinese and Western Medicine, Jiangsu Tumor Hospital Affiliated to Nantong University, Nantong 226001, China.
   Department of Oncology of Integrated Chinese and Western Medicine, Jiangsu Tumor Hospital Affiliated to Nantong University, Nantong 226001, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUL 15
PY 2021
VL 41
IS 7
BP 725
EP 9
DI 10.13703/j.0255-2930.20200615-k0002 
PG -716
WC Acupuncture Points; Cancer Pain; therapy; Hot Temperature; Humans; Moxibustion; Neoplasms; complications; Pain; Quality of Life; Treatment Outcome
UT PubMed:34259402
PM 34259402
DA 2021-07-15
ER

PT J
AU Qu, F
   Li, R
   Sun, W
   Lin, G
   Zhang, R
   Yang, J
   Tian, L
   Xing, GG
   Jiang, H
   Gong, F
   Liang, XY
   Meng, Y
   Liu, JY
   Zhou, LY
   Wang, SY
   Wu, Y
   He, YJ
   Ye, JY
   Han, SP
   Han, JS
AF Qu, Fan
   Li, Rong
   Sun, Wei
   Lin, Ge
   Zhang, Rong
   Yang, Jing
   Tian, Li
   Xing, Guo-Gang
   Jiang, Hui
   Gong, Fei
   Liang, Xiao-Yan
   Meng, Yan
   Liu, Jia-Yin
   Zhou, Li-Ying
   Wang, Shu-Yu
   Wu, Yan
   He, Yi-Jing
   Ye, Jia-Yu
   Han, Song-Ping
   Han, Ji-Sheng
TI Use of electroacupuncture and transcutaneous electrical acupoint stimulation in 
SO Journal of Zhejiang University. Science. B
LA English
DT Review
DE Electroacupuncture (EA); Group consensus; Reproductive medicine; Transcutaneous electrical acupoint stimulation (TEAS)
AB With the rapid development of assisted reproductive technology, various 
   reproductive disorders have been effectively addressed. Acupuncture-like 
   therapies, including electroacupuncture (EA) and transcutaneous electrical 
   acupoint stimulation (TEAS), become more popular world-wide. Increasing evidence 
   has demonstrated that EA and TEAS are effective in treating gynecological 
   disorders, especially infertility. This present paper describes how to select 
   acupoints for the treatment of infertility from the view of theories of 
   traditional Chinese medicine and how to determine critical parameters of electric 
   pulses of EA/TEAS based on results from animal and clinical studies. It 
   summarizes the principles of clinical application of EA/TEAS in treating various 
   kinds of reproductive disorders, such as polycystic ovary syndrome (PCOS), pain 
   induced by oocyte retrieval, diminished ovarian reserve, embryo transfer, and 
   oligospermia/ asthenospermia. The possible underlying mechanisms mediating the 
   therapeutic effects of EA/TEAS in reproductive medicine are also examined.
C1 Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
   Center of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, 
   Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Wuxi HANS Therapy Medical Technology Co., Ltd., Wuxi 214092, China.
   Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital / Key Laboratory of Assisted Reproduction, Ministry ofEducation / Beijing Key Laboratory of Reproductive Endocrinology and AssistedReproductive Technology, Beijing 100191, China.
   Center of Reproductive Medicine, the Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan 250001, China.
   Center of Reproductive Medicine, CITIC Xiangya Reproductive and Genetic Hospital, Changsha 410008, China.
   Neuroscience Research Institute, Peking University / Department of Neurobiology, School of Basic Medical Sciences / Peking University Health Science Center / KeyLab for Neuroscience, Ministry of Education/Ministry of Health, Beijing 100083,China.
   Center of Reproductive Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
   Center of Reproductive Medicine, Peking University People's Hospital, Beijing 100044, China.
   Neuroscience Research Institute, Peking University / Department of Neurobiology, School of Basic Medical Sciences / Peking University Health Science Center / KeyLab for Neuroscience, Ministry of Education/Ministry of Health, Beijing 100083,China.
   Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital / Key Laboratory of Assisted Reproduction, Ministry ofEducation / Beijing Key Laboratory of Reproductive Endocrinology and AssistedReproductive Technology, Beijing 100191, China.
   Center of Reproductive Medicine, CITIC Xiangya Reproductive and Genetic Hospital, Changsha 410008, China.
   Center of Reproductive Medicine, the Sixth Affiliated Hospital of Zhongshan University, Guangzhou 510655, China.
   Center of Reproductive Medicine, Jiangsu Province Hospital, Nanjing 210029, China.
   Center of Reproductive Medicine, Jiangsu Province Hospital, Nanjing 210029, China.
   Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
   Center of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, 
   Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Wuxi HANS Therapy Medical Technology Co., Ltd., Wuxi 214092, China.
   Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
   Center of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, 
   Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Wuxi HANS Therapy Medical Technology Co., Ltd., Wuxi 214092, China.
   Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
   Center of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, 
   Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Wuxi HANS Therapy Medical Technology Co., Ltd., Wuxi 214092, China.
   Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
   Center of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, 
   Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Wuxi HANS Therapy Medical Technology Co., Ltd., Wuxi 214092, China.
   Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
   Center of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, 
   Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Wuxi HANS Therapy Medical Technology Co., Ltd., Wuxi 214092, China.
   Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
   Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking 
   Neuroscience Research Institute, Peking University / Department of Neurobiology, School of Basic Medical Sciences / Peking University Health Science Center / KeyLab for Neuroscience, Ministry of Education/Ministry of Health, Beijing 100083,China.
   Center of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, 
   Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Wuxi HANS Therapy Medical Technology Co., Ltd., Wuxi 214092, China.
   Neuroscience Research Institute, Peking University / Department of Neurobiology, School of Basic Medical Sciences / Peking University Health Science Center / KeyLab for Neuroscience, Ministry of Education/Ministry of Health, Beijing 100083,China.
NR 0
TC 0
SN 1862-178
EI 1673-158
J9 J Zhejiang Univ Sci B
PD MAR 9
PY 2017
VL 18
IS 3
BP 186
EP 193
DI 10.1631/jzus.B1600437 
PG 7
WC Acupuncture Points; Analgesia; Animals; Asthenozoospermia; therapy; Clinical Trials as Topic; Electroacupuncture; methods; Embryo Transfer; Female; Genital Diseases, Female; therapy; Humans; Infertility, Female; therapy; Infertility, Male; therapy; Kidney; Male; Medicine, Chinese Traditional; Oligospermia; therapy; Oocyte Retrieval; Oocytes; cytology; Ovarian Reserve; Polycystic Ovary Syndrome; therapy; Pregnancy; Pregnancy Rate; Reproductive Medicine; Transcutaneous Electric Nerve Stimulation; methods; Uterus
UT PubMed:28271655
PM 28271655
DA 2017-03-09
ER

PT J
AU Li, SJ
   Shen, H
   Zhang, SC
   Shen, F
AF Li, Shi-Jie
   Shen, Hao
   Zhang, Shi-Chao
   Shen, Feng
TI [Research progress of acupuncture and moxibustion in treatment of primary liver 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Review
DE Acupuncture and moxibustion; Cancer pain; Cancer-related insomnia; Immunosuppression; Intractable hiccups; Primary liver cancer
AB The theoretical foundation of acupuncture and moxibustion is solid to support the 
   treatment of liver cancer and its related complications. A large number of 
   clinical and basic studies have deliberated the therapeutic effects of 
   acupuncture and moxibustion on liver cancer. The effects of 
   acupuncture-moxibustion therapy were summarized in terms of controlling tumor 
   lesion growth, alleviating cancer pain, reducing ascites production, attenuating 
   immunosuppression, inhibiting angiogenesis in tumors, alleviating postoperative 
   or chemotherapy-related side effects, and relieving cancer-related insomnia in 
   this review. Some problems existing in the current researches were explained and 
   the direction of future studies was explored.
C1 Clinical Medicine School of Guangdong Pharmaceutical University, Guangzhou 510006, China.
   Clinical Research Institute of The Third Affiliated Hospital, Naval Medical 
   The Fourth Department of Hepatic Surgery of The Third Affiliated Hospital, Naval Medical University, Shanghai 200438.
   Clinical Research Institute of The Third Affiliated Hospital, Naval Medical University, Shanghai 200438.
   The Fourth Department of Hepatic Surgery of The Third Affiliated Hospital, Naval 
   Clinical Research Institute of The Third Affiliated Hospital, Naval Medical University, Shanghai 200438.
   The Fourth Department of Hepatic Surgery of The Third Affiliated Hospital, Naval 
   Clinical Medicine School of Guangdong Pharmaceutical University, Guangzhou 510006, China. shenfengehbh@sina.com.
   Clinical Research Institute of The Third Affiliated Hospital, Naval Medical 
   The Fourth Department of Hepatic Surgery of The Third Affiliated Hospital, Naval Medical University, Shanghai 200438. shenfengehbh@sina.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD MAY 20
PY 2025
VL 50
IS 5
BP 605
EP 612
DI 10.13702/j.1000-0607.20240053 
PG 7
WC Humans; Moxibustion; Acupuncture Therapy; Liver Neoplasms; therapy; Animals
UT PubMed:40390619
PM 40390619
DA 2025-05-20
ER

PT J
AU Ni, XX
   Tian, T
   Liu, L
   Li, X
   Zhao, L
AF Ni, Xi-Xiu
   Tian, Tian
   Liu, Lu
   Li, Xiao
   Zhao, Ling
TI [Reporting quality of randomized controlled trials of acupuncture for cancer 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE Consolidated Standards for Reporting of Trials (CONSORT); Standards for Reporting Interventions in Controlled Trials of Acupuncture ; acupuncture; cancer pain; literature report quality; randomized controlled trial (RCT)
AB Based on the internationally-recognized Consolidated Standards for Reporting of 
   Trials (CONSORT) statement and Standards for Reporting Interventions in 
   Controlled Trials of Acupuncture (STRICTA), the reported quality of randomized 
   controlled trials (RCTs) of acupuncture for cancer pain during last 10 years were 
   evaluated. The RCTs of acupuncture for cancer pain were searched by computer. The 
   English databases included PubMed and EMbase while the Chinese databases included 
   CNKI, Wanfang, VIP and SinoMed. The publication date of the literature was from 
   March 2009 to March 2019. As a result, 22 Chinese RCTs and 13 English RCTs were 
   included. According to the CONSORT statement, among the Chinese studies, 1 RCT 
   reported primary and secondary outcomes, 8 RCTs reported randomization, none of 
   RCTs reported allocation concealment and blind method, and 4 RCTs reported 
   baseline data; among the English studies, 8 RCTs reported primary and secondary 
   outcomes, 8 RCTs reported randomization, 6 RCTs reported described allocation 
   concealment, 7 RCTs reported blind method, and 13 RCTs reported baseline data. 
   According to the STRICTA statement, among the Chinese studies, 17 RCTs reported 
   the name of acupoints, 6 RCTs reported depth of insertion, 17 RCTs reported 
   acupuncture response sought, and none of RCTs reported the qualifications of 
   acupuncturists; among the English studies, 12 RCTs reported the name of 
   acupoints, 7 RCTs reported depth of insertion, 8 RCTs reported acupuncture 
   response sought, and 7 RCTs reported the qualifications of acupuncturists. The 
   Chinese RCTs have more detailed description of acupuncture intervention and 
   theory, but not enough attention is paid to methodological description such as 
   randomization, blindness, data analysis. On the other hand, the English RCTs have 
   better description of methodology, but the description of theory and details of 
   acupuncture is relatively weak. It is concluded that more efforts were needed to 
   further improve the clinical trial design according to the CONSORT statement and 
   STRICTA statement to improve the quality of clinical evidence.
C1 College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUN 17
PY 2020
VL 40
IS 6
BP 671
EP 7
DI 10.13703/j.0255-2930.20190619-k0004 
PG -664
WC Acupuncture Therapy; Cancer Pain; therapy; Humans; Neoplasms; complications; Randomized Controlled Trials as Topic; standards
UT PubMed:32538022
PM 32538022
DA 2020-06-17
ER

PT J
AU Yang, LH
   Li, SY
   Yang, Y
   Yang, SN
   Guo, HL
   Hu, MM
   Duan, PB
   Xia, C
AF Yang, Li-Hua
   Li, Si-Yu
   Yang, Ya
   Yang, Sheng-Nan
   Guo, Hai-Li
   Hu, Ming-Ming
   Duan, Pei-Bei
   Xia, Chao
TI Effectiveness of Acupressure in Managing the Pain-Fatigue-Sleep 
SO Journal of integrative and complementary medicine
LA English
DT Journal Article
DE acupressure; meta-analysis; symptom cluster; systematic review
AB Objective: To assess the effectiveness of acupressure in addressing the symptom 
   cluster of pain, fatigue, sleep disturbances, and depression (P-F-S-D) in 
   patients with cancer through a systematic review. Methods: A comprehensive search 
   was conducted across three English-language medical databases (PubMed, Embase, 
   and the Cochrane Library) and two Chinese databases (China National Knowledge 
   Infrastructure and Wanfang). Only randomized controlled trials (RCTs) examining 
   the impact of acupressure on the P-F-S-D symptom cluster were included. Two 
   reviewers independently screened studies, evaluated the risk of bias, and 
   extracted relevant data in parallel. The risk of bias in eligible RCTs was 
   appraised using the revised Cochrane Risk of Bias tool (RoB 2.0). Meta-analysis 
   was performed using Stata software. Results: A total of 20 studies (reported in 
   21 articles) met the inclusion criteria and were classified as either having a 
   low risk of bias or some concerns regarding bias. Meta-analysis revealed that 
   acupressure achieved large-effect reductions in the P-F-S-D symptom cluster 
   compared to both sham acupoint (endpoint standardized mean difference [SMD] = 
   -0.84 [-1.05, -0.63], 4-week follow-up SMD = -0.87 [-1.35, -0.39]) and usual care 
   groups (endpoint SMD = -0.68 [-0.83, -0.53], 4-week follow-up SMD = -0.60 [-0.87, 
   -0.33]) (all p = 0.000). Initial high heterogeneity (I(2) = 65.6%-67.1%) resolved 
   after sensitivity analysis (I(2) = 19.7%-35.2%), confirming result robustness. 
   Subgroup analysis further revealed that acupressure significantly benefited 
   various symptom combinations, including P-F-S-D, P-F-S, F-S-D, F-S, P-S, and P-F. 
   No serious adverse events were reported. Conclusions: The findings of this study 
   suggest that acupressure should be considered for patients with cancer 
   experiencing the P-F-S-D symptom cluster. However, given the considerable 
   heterogeneity, potential bias, and lack of systematic adverse event reporting in 
   the included studies, further large-scale, multicenter, high-quality RCTs are 
   necessary to better evaluate the effectiveness and safety of acupressure for 
   multisymptom relief.
C1 School of Health Wellness and Education, Jiangsu Health Vocational College, Nanjing, China.
   School of Nursing, Nanjing University of Chinese Medicine, Nanjing, China.
   School of Health Wellness and Education, Jiangsu Health Vocational College, Nanjing, China.
   School of Health Wellness and Education, Jiangsu Health Vocational College, Nanjing, China.
   School of Health Wellness and Education, Jiangsu Health Vocational College, Nanjing, China.
   School of Health Wellness and Education, Jiangsu Health Vocational College, Nanjing, China.
   Department of Oncology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
   Department of Oncology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
NR 0
TC 0
SN 2768-361
EI 
J9 J Integr Complement Med
PD JUN 26
PY 2025
VL 31
IS 10
BP 860
EP 875
DI 10.1089/jicm.2024.0914 
PG 15
WC Humans; Acupressure; Neoplasms; complications; Fatigue; therapy; Depression; therapy; Randomized Controlled Trials as Topic; Sleep Wake Disorders; therapy; Pain Management; methods; Cancer Pain; therapy
UT PubMed:40569723
PM 40569723
DA 2025-06-26
ER

PT J
AU Hsiung, WT
   Chang, YC
   Yeh, ML
   Chang, YH
AF Hsiung, Wan-Ting
   Chang, Yi-Chuan
   Yeh, Mei-Ling
   Chang, Yung-Hsien
TI Acupressure improves the postoperative comfort of gastric cancer patients: A 
SO Complementary therapies in medicine
LA English
DT Journal Article
DE Acupressure; Defecation; Flatus; Gastric cancer; Nausea; Pain; Postoperative comfort; Vomiting
AB OBJECTIVE: This pilot study evaluated whether acupressure affected the 
   postoperative comfort of gastric cancer patients following a subtotal 
   gastrectomy. METHODS: A randomised controlled trial was conducted. Sixty patients 
   were recruited from 141-bed general surgery ward at a 3000-bed medical centre in 
   Northern Taiwan. Participants were randomly assigned to either a control group 
   receiving regular postoperative care or to the experimental group receiving 
   additional acupressure at acupoints of Neiquan (P6) and Zusanli (ST36) for 3 
   consecutive days. RESULTS: The similarities between two groups were in 
   postoperative pain and the onset of postoperative nausea and vomiting (PONV) at 
   the baseline. Following acupressure, significant differences were found in 
   postoperative pain (P=.03) and time of first flatus (P=.04); but not PONV 
   (P=.49), nor the time of first defecation (P=.34). CONCLUSIONS: Acupressure is a 
   simple, noninvasive, safe, and economical procedure for improving the comfort of 
   patients who undergo surgery for gastric cancer. Acupressure at the P6 and ST36 
   acupoints can improve postoperative comfort by alleviating pain and decreasing 
   the time until first flatus. However, additional research is necessary to 
   elucidate how acupressure can improve postoperative outcomes.
C1 Department of Nursing, Taipei Veterans General Hospital, Taiwan, ROC.
   Department of Nursing, Fooyin University, Taiwan, ROC
   National Taipei University of Nursing and Health Sciences, Taiwan, ROC.
   School of Nursing, National Taipei University of Nursing and Health Sciences, Taiwan, ROC. 
   China Medical University and Hospital, Taiwan, ROC.
EM meiling@ntunhs.edu.tw
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD JUN 9
PY 2015
VL 23
IS 3
BP 339
EP 46
DI 10.1016/j.ctim.2015.03.010 
PG -293
WC Acupressure; Acupuncture Points; Aged; Female; Gastrectomy; adverse effects; Humans; Male; Middle Aged; Pain, Postoperative; epidemiology; Postoperative Nausea and Vomiting; epidemiology; Stomach Neoplasms; epidemiology
UT PubMed:26051568
PM 26051568
DA 2015-06-09
ER

PT J
AU Li, X
   Wang, R
   Shi, X
   Su, J
   Pan, Y
   Tian, J
   Yang, K
AF Li, Xiuxia
   Wang, Rong
   Shi, Xiue
   Su, Jinlong
   Pan, Yuanqing
   Tian, Jinhui
   Yang, Kehu
TI Reporting Characteristics and Quality of Systematic Reviews of Acupuncture 
SO Pain practice : the official journal of World Institute of Pain
LA English
DT Review
DE acupuncture analgesia; characteristics; quality; systematic reviews
AB BACKGROUND: Evaluating the clinical efficacy of acupuncture analgesia with 
   systematic reviews (SRs) has attracted wide interest. OBJECTIVE: To collect a 
   sample of published SRs on acupuncture analgesia in PubMed and examine them in 
   terms of reporting characteristics and quality. METHODS: A search in PubMed was 
   performed in January 2016. All SRs on acupuncture analgesia were included. To 
   assess the quality of the SRs, AMSTAR tool and PRISMA Statements were used. 
   RESULTS: One hundred and nine SRs were included in our analysis, the yearly 
   number of publications ranging from 1 in 1997 to 15 in 2015. Only 17% of these 
   publications were Cochrane Systematic Reviews, and 94% were published in Science 
   Citation Index journals. The United Kingdom was the country with the higher 
   number of publications. Low back pain, headache, cancer pain, and labor pain were 
   the most reported diseases or phenotypes. Nearly 73% of these SRs conducted a 
   meta-analysis, 58% revealed positive results, 53% used RevMan software to analyze 
   data, and 44% used the Cochrane Risk of Bias Tool for quality assessment. Only a 
   few SRs assessed the likelihood of publication bias, reported details about the 
   protocol and the registration information, and performed additional analyses. 
   CONCLUSIONS: The quantity and the quality of SRs regarding acupuncture analgesia 
   have been promoted in recent years. More effort should be expended on the 
   assessment of publication bias, the provision of detailed information about the 
   protocol and the registration process, and the implementation of additional 
   analyses to improve the validity of the SRs.
C1 Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
   Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu 
   Gansu University of Chinese Medicine, Lanzhou, China.
   Department of Orthopedics, the General Hospital of PLA, Lanzhou, China.
   Rehabilitation Center Hospital of Gansu Province, Lanzhou, China.
   Pharmaceutical Center, Lanzhou University Second Hospital, Lanzhou, China.
   Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
   Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu 
   Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
   Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu 
   Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
   Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu 
NR 0
TC 0
SN 1533-250
EI 
J9 Pain Pract
PD JAN 14
PY 2017
VL 17
IS 8
BP 1066
EP 1074
DI 10.1111/papr.12555 
PG 8
WC Acupuncture Analgesia; Humans; PubMed; Publishing; standards; Review Literature as Topic
UT PubMed:28083991
PM 28083991
DA 2017-01-14
ER

PT J
AU He, C
   Tang, QX
   Li, YX
   He, K
   Hou, ZL
AF He, Chi
   Tang, Qing-Xi
   Li, Ying-Xia
   He, Kai
   Hou, Zhi-Ling
TI Effectiveness of electroacupuncture for pain after osteosarcoma post surgery: A 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: This study will assess the effectiveness of electroacupuncture (EA) 
   for pain in patients with osteosarcoma post surgery (OSPS). METHODS: In this 
   study, we will comprehensively search the following electronic databases from 
   inception to the present without language restrictions: Cochrane Library, EMBASE, 
   MEDLINE, the Cumulative Index to Nursing and Allied Health Literature, the Allied 
   and Complementary Medicine Database, and Chinese Biomedical Literature Database. 
   Two authors will independently carry out study selection, data extraction, and 
   methodological assessments. RevMan 5.3 software will be used for statistical 
   analysis. RESULTS: The primary outcome is pain intensity. The secondary outcomes 
   consist of event-free survival, overall survival, quality of life, and adverse 
   events. CONCLUSION: The findings of this study will provide helpful evidence of 
   EA treatment for patients with OSPS. PROSPERO REGISTRATION NUMBER: PROSPERO 
   CRD42019146696.
C1 Department of Anesthesiology.
   Department of Emergency Surgery, First Affiliated Hospital of Jiamusi University, Jiamusi.
   Department of Emergency Surgery, First Affiliated Hospital of Jiamusi University, Jiamusi.
   Department of Orthopedis, Harbin Second Hospital, Harbin, China.
   Department of Anesthesiology.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD NOV 7
PY 2019
VL 98
IS 44
BP e17381
EP e17381
DI 10.1097/MD.0000000000017381 
PG 1
WC Humans; Cancer Pain; therapy; Disease-Free Survival; Electroacupuncture; adverse effects; Osteosarcoma; surgery; Quality of Life; Randomized Controlled Trials as Topic; Research Design; Systematic Reviews as Topic
UT PubMed:31689744
PM 31689744
DA 2019-11-07
ER

PT J
AU Dommerholt, J
   Finnegan, M
   Hooks, T
   Grieve, R
AF Dommerholt, Jan
   Finnegan, Michelle
   Hooks, Todd
   Grieve, Rob
TI A critical overview of the current myofascial pain literature - September 2016.
SO Journal of bodywork and movement therapies
LA English
DT Review
DE Dry needling; Manual therapy; Myofascial pain syndrome; Trigger points
AB This edition of the overview of the current myofascial pain literature includes 
   24 studies, case reports and systematic and narrative reviews. Surprisingly, five 
   of the 24 papers were difficult to read and interpret mostly because of a poor 
   mastery of the English language. It is somewhat surprising that journal editors 
   and reviewers would accept papers that are needlessly difficult to read and not 
   direct the authors to language services or others who could improve the quality 
   of the writings. Of course, it is exciting that researchers and clinicians from 
   all over the world continue to focus on myofascial pain and attempt to shed new 
   light on the complexity of the problem to improve the clinical decision-making 
   process and eventually clinical approaches and outcomes. There were no new papers 
   on manual therapies, but many focused on dry needling.
C1 Bethesda Physiocare, Bethesda, MD, USA
   Myopain Seminars, Bethesda, MD, USA. 
   Bethesda Physiocare, Bethesda, MD, USA
   Myopain Seminars, Bethesda, MD, USA. 
   New Orleans Pelicans, New Orleans, LA, USA. 
   Department of Allied Health Professions, Faculty of Health and Applied Sciences, University of the West of England, Blackberry Hill, Bristol, United Kingdom.
EM Rob.Grieve@uwe.ac.uk
NR 0
TC 0
SN 1532-928
EI 
J9 J Bodyw Mov Ther
PD NOV 7
PY 2016
VL 20
IS 4
BP 879
EP 892
DI 10.1016/j.jbmt.2016.09.010 
PG 13
WC Acupuncture Therapy; methods; Electric Stimulation Therapy; methods; Humans; Musculoskeletal Manipulations; methods; Myofascial Pain Syndromes; diagnosis; Needles; Neoplasms; therapy; Observer Variation; Pain Management; methods; Pain Measurement; Physical Therapy Modalities; Reaction Time; Reproducibility of Results; Shoulder Pain; therapy; Temporomandibular Joint Disorders; diagnosis; Trigger Points; Veterans
UT PubMed:27814870
PM 27814870
DA 2016-11-07
ER

PT J
AU Behzadmehr, R
   Dastyar, N
   Moghadam, MP
   Abavisani, M
   Moradi, M
AF Behzadmehr, Razieh
   Dastyar, Neda
   Moghadam, Mahdieh Poodineh
   Abavisani, Mahnaz
   Moradi, Mandana
TI Effect of complementary and alternative medicine interventions on cancer related 
SO Complementary therapies in medicine
LA English
DT Journal Article
DE Breast neoplasm; Cancer related pain; Complementary and alternative medicine; Systematic review
AB OBJECTIVE: This systematic review aimed to evaluate the efficacy of CAM 
   interventions for cancer-related pain in breast cancer patients. METHODS: 
   Databases (PubMed, Scopus, Web of Science, and EMBASE) were searched from January 
   1, 2000, up to April 31, 2019, using the keywords: Complementary and alternative 
   medicine therapies and cancer related pain. Standard tools were used to evaluate 
   the quality of the studies included. RESULTS: Of the 3742 articles found, 46 
   articles comprising 3685 participants entered the final phase. Our results 
   indicate that interventions including acupuncture/acupressure, tai chi/qi gong, 
   hypnosis, meditation, music therapy, yoga, massage, reflexology, and Reiki 
   improve cancer-related pain in breast cancer patients. However, aromatherapy had 
   no effect on the same. CONCLUSIONS: Despite the positive effect of various CAM 
   interventions in reducing cancer-related pain, necessary precautions should be 
   adopted to use them alongside other treatments to control cancer pain in the 
   clinical setting.
C1 Department of Radiology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
   Department of Midwifery, Jiroft University of Medical Sciences, Jiroft, Iran.
   Department of Nursing, Faculty of Nursing and Midwifery, Zabol University of Medical Sciences, Zabol, Iran.
   MSc of Medical Surgical Nursing, Department of Nursing, Neyshabur University of Medical Sciences, Neyshabur, Iran.
   Clinical Pharmacy Department, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran. 
EM mmandana310@gmail.com
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD MAR 10
PY 2020
VL 49
IS 
BP 102318
EP 102318
DI 10.1016/j.ctim.2020.102318 
PG 0
WC Breast Neoplasms; complications; Cancer Pain; etiology; Complementary Therapies; methods; Female; Humans
UT PubMed:32147038
PM 32147038
DA 2020-03-10
ER

PT J
AU Blackburn, H
   West, S
AF Blackburn, Helen
   West, Sandra
TI Management of Postembolization Syndrome Following Hepatic Transarterial 
SO Cancer nursing
LA English
DT Review
AB BACKGROUND: Transarterial chemoembolization (TACE) is an established treatment in 
   managing liver primary neoplasms or liver metastases. Postembolization syndrome 
   (PES) is a common adverse event defined as fever without associated sepsis, pain 
   in the right upper quadrant, and nausea and/or vomiting. OBJECTIVE: This 
   integrative review aims to identify effective management strategies for PES or 
   one of its characterizing symptoms (fever, pain, and nausea and/or vomiting). 
   METHODS: Searches of electronic databases MEDLINE, EMBASE, and CINAHL were 
   conducted. Fifteen articles were identified for inclusion. Seven addressed all 
   symptoms of PES, and 8 studies focused on individual symptoms of PES. RESULTS: 
   Interventions identified are intra-arterial lidocaine, oral and intravenous 
   analgesics, steroids, wrist-ankle acupuncture, antibiotics, and 5-HT3 receptor 
   antagonists. Findings are explicated according to individual symptoms of PES. 
   Intra-arterial lidocaine, steroids, and a 5-HT3 receptor antagonist are found to 
   offer potential benefit in the management of PES symptoms. CONCLUSION: A number 
   of interventions have shown potential benefit in the management of PES. A 
   systemic approach using combination therapy is necessary to effectively manage 
   characterizing symptoms. Further research is needed to determine the impact of 
   primary disease site, TACE technique, and chemotherapeutic agent on PES. 
   IMPLICATIONS FOR PRACTICE: Oncology nurses are uniquely placed to undertake 
   thorough patient assessment after TACE and implement early intervention to 
   effectively manage PES.
C1 Author Affiliations: North Shore Private Hospital (Ms Blackburn) and Sydney Nursing School, University of Sydney (Ms Blackburn and Dr West), New South Wales,Australia.
NR 0
TC 0
SN 1538-980
EI 
J9 Cancer Nurs
PD OCT 21
PY 2015
VL 39
IS 5
BP E1
EP E18
DI 10.1097/NCC.0000000000000302 
PG 1
WC Abdominal Pain; therapy; Acupuncture Analgesia; methods; Administration, Oral; Analgesics; therapeutic use; Anti-Bacterial Agents; therapeutic use; Chemoembolization, Therapeutic; methods; Disease Management; Drug Therapy, Combination; methods; Fever of Unknown Origin; therapy; Humans; Infusions, Intra-Arterial; methods; Injections, Intravenous; methods; Lidocaine; therapeutic use; Liver Neoplasms; drug therapy; Morphine; therapeutic use; Oncology Nursing; methods; Oxycodone; therapeutic use; Postoperative Nausea and Vomiting; therapy; Serotonin 5-HT3 Receptor Antagonists; therapeutic use; Steroids; therapeutic use
UT PubMed:26484962
PM 26484962
DA 2015-10-21
ER

PT J
AU Shen, Q
   Deng, D
   Li, G
   Ruan, J
   Shao, X
   Wang, P
   Li, X
   Li, R
   Bao, W
   Chen, W
   Lu, C
AF Shen, Qiongying
   Deng, Dehou
   Li, Guangliang
   Ruan, Jiayin
   Shao, Xiying
   Wang, Peipei
   Li, Xiaoyu
   Li, Rongrong
   Bao, Wenlong
   Chen, Weiji
   Lu, Chao
TI Electroacupuncture frequency for chemotherapy-induced neuropathy in breast 
SO The oncologist
LA English
DT Journal Article
DE breast cancer; chemotherapy-induced peripheral neuropathy; electroacupuncture
AB BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent 
   dose-limiting toxicity in breast cancer patients. Electroacupuncture (EA) shows 
   promise but optimal stimulation parameters remain undefined. We conducted a 
   randomized trial comparing EA frequencies for CIPN. METHODS: This single-center, 
   single-blind trial randomized patients to 2, 100, and 2/100 Hz EA, or mecobalamin 
   (Mecbl). The primary outcome was the patient neurotoxicity questionnaire (PNQ) 
   response rate at Week 4. Secondary outcomes included PNQ scores, National Cancer 
   Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) grades at 
   Weeks 4/8, and European Organization for Research and Treatment of Cancer Quality 
   of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy 20 (EORTC 
   QLQ-CIPN20) and Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) scales. 
   RESULTS: 2/100 Hz EA achieved the highest overall response rate. Both 2 and 
   2/100 Hz EA improved PNQ sensory scores at Week 4. Sensory scores improved across 
   groups, while motor scores decreased with 2 and 2/100 Hz EA. Only 2 Hz EA 
   improved autonomic function. For quality-of-life, 2 Hz EA enhanced physical 
   function, fatigue, pain and insomnia, while 2/100 Hz EA improved nausea/vomiting, 
   constipation, appetite and global health with additional pain relief at Week 4. 
   The 100 Hz EA group showed no significant benefits in these domains. CONCLUSIONS: 
   This study preliminarily explored EA's potential benefits for CIPN, with 2/100 Hz 
   showing the highest response rate and 2 Hz demonstrating sensory improvement 
   advantages. Different frequencies produced distinct therapeutic profiles. Further 
   research should evaluate frequency-specific effects of EA for CIPN.
C1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Department of Traditional Chinese Medicine, Zhejiang Cancer Hospital, Hangzhou 310022, China.
   Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China.
   School of Nursing, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region 999077, China.
   Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China.
   Department of Traditional Chinese Medicine, Zhejiang Cancer Hospital, Hangzhou 310022, China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang, Chinese Medical University (Zhongshan Hospital of Zhejiang Province),Hangzhou 310009, China.
   Department of Traditional Chinese Medicine, Zhejiang Cancer Hospital, Hangzhou 310022, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang, Chinese Medical University (Zhongshan Hospital of Zhejiang Province),Hangzhou 310009, China.
   Department of Traditional Chinese Medicine, Zhejiang Cancer Hospital, Hangzhou 310022, China.
NR 0
TC 0
SN 1549-490
EI 1083-715
J9 Oncologist
PD AUG 19
PY 2025
VL 30
IS 9
BP 
EP 
DI 10.1093/oncolo/oyaf262 
PG 0
WC Humans; Electroacupuncture; methods; Female; Breast Neoplasms; drug therapy; Middle Aged; Peripheral Nervous System Diseases; therapy; Quality of Life; Aged; Adult; Antineoplastic Agents; adverse effects; Single-Blind Method; Vitamin B 12; analogs & derivatives
UT PubMed:40828899
PM 40828899
DA 2025-08-19
ER

PT J
AU He, YH
   Xu, NG
   Zhang, HB
   Xue, CL
   Kang, FQ
   Wang, Q
   Li, JY
   Ge, L
   Guo, XF
AF He, Yi-Han
   Xu, Neng-Gui
   Zhang, Hai-Bo
   Xue, Chang-Li
   Kang, Fu-Qin
   Wang, Qi
   Li, Jie-Yun
   Ge, Long
   Guo, Xin-Feng
TI [Acupoint selection for cancer pain: based on current evidence and Delphi 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE Delphi method; acupoint selection; acupuncture; cancer pain; literature research
AB Based on literature research and Delphi expert consensus method, the important 
   acupoints for cancer pain was summarized to provide evidence basis for the 
   formulation of Clinical Practice Guide of Acupuncture in the Treatment of Cancer 
   Pain. Through systematic search of Chinese and English databases, 28 clinical 
   studies regarding acupuncture for cancer pain were included. The acupoint 
   selection methods and high-frequency acupoints were summarized and analyzed. 
   Based on this, a Delphi questionnaire was designed and two rounds of 
   questionnaire survey on 30 experts in acupuncture and tumor related fields in 
   China and abroad were conducted. As a result, it was suggested that the 
   individualized acupoint selection should be adopted for acupuncture treatment of 
   cancer pain, with Zusanli (ST 36), Hegu (LI 4), Taichong (LR 3), Sanyinjiao (SP 
   6), Yanglingquan (GB 34) and ashi points as the main acupoints. Combined with 
   clinical research evidence and expert consensus, the important acupoints for 
   cancer pain were identified. However, clinical acupoint selection still needed 
   further research and refinement.
C1 Second Affiliated Hospital of Guangzhou University of CM/Guangdong Hospital of TCM, Guangzhou 510120, China
   Second Clinical Medical College of GuangzhouUniversity of CM, Guangzhou 510120, Guangdong Province
   Royal Melbourne Instituteof Technology University, Melbourne 3083, Australia.
   South China Research Center for Acupuncture and Moxibustion, Guangzhou University of CM.
   Second Affiliated Hospital of Guangzhou University of CM/Guangdong Hospital of TCM, Guangzhou 510120, China
   Second Clinical Medical College of GuangzhouUniversity of CM, Guangzhou 510120, Guangdong Province.
   Second Affiliated Hospital of Guangzhou University of CM/Guangdong Hospital of TCM, Guangzhou 510120, China
   Second Clinical Medical College of GuangzhouUniversity of CM, Guangzhou 510120, Guangdong Province
   Royal Melbourne Instituteof Technology University, Melbourne 3083, Australia.
   Second Clinical Medical College of Guangzhou University of CM, Guangzhou 510120, Guangdong Province.
   Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University.
   Evidence-Based Medicine Research Center, School of Basic Medical Sciences, Lanzhou University.
   Key Laboratory of Evidence-Based Medicine and Clinical Transformation of Gansu Province.
   Second Affiliated Hospital of Guangzhou University of CM/Guangdong Hospital of TCM, Guangzhou 510120, China
   Second Clinical Medical College of GuangzhouUniversity of CM, Guangzhou 510120, Guangdong Province.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD OCT 11
PY 2021
VL 41
IS 10
BP 1161
EP 5
DI 10.13703/j.0255-2930.20200831-k0002 
PG -1156
WC Acupuncture Points; Acupuncture Therapy; Cancer Pain; therapy; Humans; Meridians; Neoplasms; complications; Publications
UT PubMed:34628751
PM 34628751
DA 2021-10-11
ER

PT J
AU Liou, KT
   Baser, R
   Romero, SAD
   Green, J
   Li, QS
   Orlow, I
   Panageas, KS
   Mao, JJ
AF Liou, Kevin T
   Baser, Ray
   Romero, Sally A D
   Green, Jamie
   Li, Q Susan
   Orlow, Irene
   Panageas, Katherine S
   Mao, Jun J
TI Personalized electro-acupuncture versus auricular-acupuncture comparative 
SO Medicine
LA English
DT Journal Article
AB INTRODUCTION: Chronic pain is a leading cause of disability and remains 
   under-treated in nearly half of patients with cancer. The opioid crisis has 
   highlighted an urgent public health need for effective nonpharmacological pain 
   management. Electroacupuncture (EA) and Battlefield Acupuncture (BFA) represent 
   nonpharmacological modalities used in clinical practice to manage pain; however, 
   their effectiveness has not been rigorously evaluated in oncology settings. 
   METHODS: We describe the design of a 3-arm, parallel, single-center, multisite 
   randomized controlled trial that investigates EA and BFA versus usual-care 
   wait-list control (WLC) for chronic musculoskeletal pain among 360 patients with 
   diverse cancer types across various stages. The primary aim is to compare effects 
   of EA and BFA versus WLC on pain, physical function, and co-morbid symptoms. The 
   secondary aim is to examine the interaction between patient outcome expectancy 
   and acupuncture modality (EA vs BFA) on pain reduction. The tertiary aim is to 
   evaluate the association between genetic polymorphisms and responses to 
   acupuncture. Patients will be randomized in a 2:2:1 ratio to EA:BFA:WLC. 
   Acupuncture groups will receive weekly treatments over 10 weeks. WLC will receive 
   usual care over the same evaluation period as the acupuncture groups. The primary 
   endpoint will be the change in average pain intensity score from baseline to week 
   12. We will collect validated patient-reported outcomes and blood/saliva samples 
   at multiple timepoints over 24 weeks. DISCUSSION: Our findings will advance 
   nonpharmacological pain management in oncology and inform personalized treatment 
   approaches that integrate individuals' expectations and genetic biomarkers to 
   deliver "precision" acupuncture to cancer patients with chronic pain. TRIAL 
   REGISTRATION: ClinicalTrials.gov Identifier: NCT02979574.
C1 Integrative Medicine Service, Department of Medicine.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
   Department of Family Medicine and Public Health, UC San Diego School of Medicine, San Diego, CA.
   Integrative Medicine Service, Department of Medicine.
   Integrative Medicine Service, Department of Medicine.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
   Integrative Medicine Service, Department of Medicine.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JUN 3
PY 2020
VL 99
IS 21
BP e20085
EP e20085
DI 10.1097/MD.0000000000020085 
PG 1
WC Acupuncture Therapy; methods; Adult; Cancer Survivors; Chronic Pain; therapy; Humans; Musculoskeletal Pain; therapy; Pain Management; methods; Pain Measurement; methods; Quality of Life; Randomized Controlled Trials as Topic
UT PubMed:32481275
PM 32481275
DA 2020-06-03
ER

PT J
AU Huemer, M
   Jahn-Kuch, D
   Hofmann, G
   Pichler, M
AF Huemer, Matthias
   Jahn-Kuch, Daniela
   Hofmann, Guenter
   Pichler, Martin
TI A case report of immediate effects of acupuncture on neuropathic cancer 
SO Complementary therapies in clinical practice
LA English
DT Journal Article
DE Acupuncture; Cancer pain; Complementary & alternative medicine (CAM); Neuropathic pain; Pain management; Palliative care
AB INTRODUCTION: Acupuncture is a promising treatment for visceral cancer pain, but 
   to date, evidence for immediate effects on neuropathic pain is limited. CASE 
   PRESENTATION: This report presents a case of immediate pain relief by 
   single-needle acupuncture on opioid-refractory neuropathic breakthrough pain in a 
   78-year-old female breast cancer patient with cervical bone metastases. 
   Acupuncture was applied at a single point neuroanatomically correlating to the 
   pain affected spinal segment. DISCUSSION: Immediately after acupuncture, the 
   patient reported a complete pain relief lasting for one day. In the following 
   days, neuropathic breakthrough pain was better manageable with reduced dosages of 
   opioids. Acupuncture is possibly effective in providing immediate and safe pain 
   relief in neuropathic cancer pain through neuromodulating effects on the spinal 
   and central nervous level. Randomized controlled studies with individualized 
   acupuncture point protocols are needed to establish efficacy and safety.
C1 Department of Internal Medicine, Division of Oncology, Palliative Care Unit, Medical University of Graz, Graz, Austria.
   Department of Internal Medicine, Division of Oncology, Palliative Care Unit, Medical University of Graz, Graz, Austria.
   Department of Internal Medicine, Division of Oncology, Palliative Care Unit, Medical University of Graz, Graz, Austria.
   Department of Internal Medicine, Division of Oncology, Medical University of Graz, Graz, Austria. 
EM martin.pichler@medunigraz.at
NR 0
TC 0
SN 1873-694
EI 
J9 Complement Ther Clin Pract
PD MAY 19
PY 2022
VL 48
IS 
BP 101599
EP 101599
DI 10.1016/j.ctcp.2022.101599 
PG 0
WC Acupuncture Therapy; adverse effects; Aged; Analgesics, Opioid; Breakthrough Pain; complications; Cancer Pain; therapy; Female; Humans; Neoplasms; Neuralgia; therapy
UT PubMed:35584602
PM 35584602
DA 2022-05-19
ER

PT J
AU Ba, DS
   Guo, Y
   Chen, B
   Zhai, JB
   Wang, B
   Chen, AX
   Zhu, Z
   Sun, BX
   Shi, Y
   Liu, XX
   Chen, ZL
   Geng, LQ
   Guo, Y
AF Ba, Dong-Sheng
   Guo, Yang
   Chen, Bo
   Zhai, Jing-Bo
   Wang, Bin
   Chen, Ao-Xiang
   Zhu, Zheng
   Sun, Bin-Xu
   Shi, Yu
   Liu, Xi-Xian
   Chen, Ze-Lin
   Geng, Lian-Qi
   Guo, Yi
TI Core concomitant symptoms reported by the patients with breast cancer in 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Breast cancer; Concomitant symptoms; Endocrine treatment; Expectation; Willingness to use acupuncture
AB OBJECTIVES: To investigate the most common concomitant symptoms and the urgent 
   demand of solution in the breast cancer patients undergoing postoperative 
   endocrine treatment, as well as the acceptance and expectation of acupuncture in 
   the patients so as to provide the scientific data for promoting the application 
   of acupuncture in the breast cancer patients. METHODS: Breast cancer patients 
   treated in Tianjin Medical University Cancer Institute and Hospital from January 
   2022 to March 2023 were randomly selected as the subjects. Using "questionnaire 
   star" website, the questionnaire was conducted to investigate the relevant 
   concomitant symptoms of the patients in postoperative endocrine treatment and the 
   questions related to acupuncture treatment. RESULTS: In this study, 229 
   questionnaires were distributed and 211 valid ones were collected, with the 
   response rate of 92.1%. Among these patients, the first three common symptoms 
   were sleep disorders (157 cases, 74.4%), hot flashes (138 cases, 65.4%) and joint 
   / muscle pain (118 cases, 55.9%)；the top three symptoms to be solved the most 
   urgently were sleep disorders (131 cases, 62.1%), joint / muscle pain (62 cases, 
   29.4%) and hot flashes (45 cases, 21.3%). 79.1% of the patients (167 cases) were 
   willing to receive acupuncture treatment because of the high expectations on its 
   potential effect (93%). 20.9% of them (44 cases) refused acupuncture because they 
   were worried not to be treated by the experienced physicians of TCM (52%) or 
   afraid of needling feelings (48%). The average expectation value of acupuncture 
   treatment was 4.02 points (5 points for the total score) among patients willing 
   to receive acupuncture treatment. The main purposes of receiring acupuncture for 
   the patients undergoing endocrine treatment were to strengthen the immune 
   function (92%), reduce the adverse reactions (83%), and improve the physical 
   condition (75%), et al. CONCLUSIONS: Sleep disorder is one of the most concerned 
   symptoms in endocrine treatment for the patients after breast cancer surgery. The 
   patients highly expect for acupuncture treatment even though some patients 
   dislike the needling sensation. How to provide the acceptable and high-quality 
   acupuncture services for cancer patients will be one of the major directions of 
   acupuncture research in the future.
C1 College of Acupuncture-moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193.
   National Clinical Research Center of Chinese Acupuncture and Moxibustion, Tianjin 
   College of Acupuncture-moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. tjutcmchenbo@163.com.
   National Clinical Research Center of Chinese Acupuncture and Moxibustion, Tianjin 
   Tianjin Binhai Xinqu Hospital of Traditional Chinese Medicine, The Forth Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300451. tjutcmchenbo@163.com.
   School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin 301617.
   Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center for Cancer, Tianjin 300181.
   Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center for Cancer, Tianjin 300181.
   College of Acupuncture-moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193.
   College of Acupuncture-moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   National Clinical Research Center of Chinese Acupuncture and Moxibustion, Tianjin 301617.
   College of Acupuncture-moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Tianjin Binhai Xinqu Hospital of Traditional Chinese Medicine, The Forth 
   National Clinical Research Center of Chinese Acupuncture and Moxibustion, Tianjin 301617.
   College of Acupuncture-moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Tianjin Binhai Xinqu Hospital of Traditional Chinese Medicine, The Forth 
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUL 18
PY 2024
VL 49
IS 7
BP 707
EP 714
DI 10.13702/j.1000-0607.20230939 
PG 7
WC Humans; Female; Acupuncture Therapy; Breast Neoplasms; therapy; Middle Aged; Cross-Sectional Studies; Adult; Sleep Wake Disorders; therapy; Surveys and Questionnaires; Aged; Hot Flashes; therapy; Myalgia; therapy; Young Adult
UT PubMed:39020489
PM 39020489
DA 2024-07-18
ER

PT J
AU Dilaveri, CA
   Croghan, IT
   Mallory, MJ
   Dion, LJ
   Fischer, KM
   Schroeder, DR
   Martinez-Jorge, J
   Nguyen, MT
   Fokken, SC
   Bauer, BA
   Wahner-Roedler, DL
AF Dilaveri, Christina A
   Croghan, Ivana T
   Mallory, Molly J
   Dion, Liza J
   Fischer, Karen M
   Schroeder, Darrell R
   Martinez-Jorge, Jorys
   Nguyen, Minh-Doan T
   Fokken, Shawn C
   Bauer, Brent A
   Wahner-Roedler, Dietlind L
TI Massage Compared with Massage Plus Acupuncture for Breast Cancer Patients 
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
DE acupuncture; integrative therapy; massage; stress
AB Objectives: Integrative therapies have been incorporated increasingly into health 
   and wellness in the United States in recent decades. Their potential benefits are 
   under evaluation in various situations, including pain and symptom relief for 
   cancer patients and survivors. This pilot study evaluated whether combining two 
   integrative complementary approaches augments a patient's benefit by reducing 
   postoperative stress, pain, anxiety, muscle tension, and fatigue compared with 
   one integrative complementary approach alone. Design: Patients undergoing 
   autologous tissue breast reconstruction were randomly assigned to one of two 
   postoperative complementary alternative therapies for three consecutive days. All 
   participants were observed for up to 3 months. Subjects: Forty-two participants 
   were recruited from January 29, 2016 to July 11, 2018. Interventions: Twenty-one 
   participants were randomly assigned to massage alone and 21 to massage and 
   acupuncture. Outcome measures: Stress, anxiety, relaxation, nausea, fatigue, 
   pain, and mood (score 0-10) were measured at enrollment before surgery and 
   postoperative days 1, 2, and 3 before and after the intervention. Patient 
   satisfaction was evaluated. Results: Stress decreased from baseline for both 
   Massage-Only Group and Massage+Acupuncture Group after each treatment 
   intervention. Change in stress score from baseline decreased significantly more 
   in the Massage-Only Group at pretreatment and posttreatment (p = 0.03 and 
   p = 0.04). After adjustment for baseline values, change in fatigue, anxiety, 
   relaxation, nausea, pain, and mood scores did not differ between groups. When 
   patients were asked whether they would recommend the study, 100% (19/19) of 
   Massage-Only Group and 94% (17/18) of Massage+Acupuncture Group responded yes 
   (p = 0.49). Conclusion: No additive beneficial effects were observed with 
   addition of acupuncture to massage for pain, anxiety, relaxation, nausea, 
   fatigue, and mood. Combined massage and acupuncture was not as effective in 
   reducing stress as massage alone, although both groups had significant stress 
   reduction. These findings indicate a need for larger studies to explore these 
   therapies further.
C1 Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
   Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
   Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
   Department of Medicine Clinical Research Office, Mayo Clinic, Rochester, MN, USA.
   Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
   Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
   Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
   Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
   Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, MN, USA.
   Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, MN, USA.
   Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
   Department of Medicine Clinical Research Office, Mayo Clinic, Rochester, MN, USA.
   Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
   Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
NR 0
TC 0
SN 1557-770
EI 1075-553
J9 J Altern Complement Med
PD JUL 17
PY 2020
VL 26
IS 7
BP 602
EP 609
DI 10.1089/acm.2019.0479 
PG 7
WC Acupuncture Therapy; Adult; Affect; Aged; Anxiety; etiology; Breast Neoplasms; complications; Combined Modality Therapy; Fatigue; etiology; Female; Humans; Massage; Middle Aged; Nausea; etiology; Pain; etiology; Pain Management; Patient Satisfaction; Pilot Projects; Postoperative Care; methods; Postoperative Period; Plastic Surgery Procedures; adverse effects; Relaxation; Stress, Psychological; etiology
UT PubMed:32673082
PM 32673082
DA 2020-07-17
ER

PT J
AU Pfister, DG
   Cassileth, BR
   Deng, GE
   Yeung, KS
   Lee, JS
   Garrity, D
   Cronin, A
   Lee, N
   Kraus, D
   Shaha, AR
   Shah, J
   Vickers, AJ
AF Pfister, David G
   Cassileth, Barrie R
   Deng, Gary E
   Yeung, K Simon
   Lee, Jennifer S
   Garrity, Donald
   Cronin, Angel
   Lee, Nancy
   Kraus, Dennis
   Shaha, Ashok R
   Shah, Jatin
   Vickers, Andrew J
TI Acupuncture for pain and dysfunction after neck dissection: results of a 
SO Journal of clinical oncology : official journal of the American Society of 
LA English
DT Journal Article
AB PURPOSE: To determine whether acupuncture reduces pain and dysfunction in 
   patients with cancer with a history of neck dissection. The secondary objective 
   is to determine whether acupuncture relieves dry mouth in this population. 
   PATIENTS AND METHODS: Patients at a tertiary cancer center with chronic pain or 
   dysfunction attributed to neck dissection were randomly assigned to weekly 
   acupuncture versus usual care (eg, physical therapy, analgesia, and/or 
   anti-inflammatory drugs, per patient preference or physician recommendation) for 
   4 weeks. The Constant-Murley score, a composite measure of pain, function, and 
   activities of daily living, was the primary outcome measure. Xerostomia, a 
   secondary end point, was assessed using the Xerostomia Inventory. RESULTS: 
   Fifty-eight evaluable patients were accrued and randomly assigned from 2004 to 
   2007 (28 and 30 patients on acupuncture and control arms, respectively). 
   Constant-Murley scores improved more in the acupuncture group (adjusted 
   difference between groups = 11.2; 95% CI, 3.0 to 19.3; P = .008). Acupuncture 
   produced greater improvement in reported xerostomia (adjusted difference in 
   Xerostomia Inventory = -5.8; 95% CI, -0.9 to -10.7; P = .02). CONCLUSION: 
   Significant reductions in pain, dysfunction, and xerostomia were observed in 
   patients receiving acupuncture versus usual care. Although further study is 
   needed, these data support the potential role of acupuncture in addressing 
   post-neck dissection pain and dysfunction, as well as xerostomia.
C1 Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. pfisterd@mskcc.org
NR 0
TC 0
SN 1527-775
EI 0732-183
J9 J Clin Oncol
PD APR 22
PY 2010
VL 28
IS 15
BP 2565
EP 70
DI 10.1200/JCO.2009.26.9860 
PG -2495
WC Acupuncture Therapy; methods; Aged; Female; Head and Neck Neoplasms; surgery; Humans; Male; Middle Aged; Neck Dissection; adverse effects; Neck Pain; etiology; Pain, Postoperative; etiology; Xerostomia; complications
UT PubMed:20406930
PM 20406930
DA 2010-04-22
ER

PT J
AU Gu, YM
   Meng, X
   Liang, JY
   Xia, Y
   Huang, JW
   Wang, K
   Ju, ZY
AF Gu, Yi-Ming
   Meng, Xiang
   Liang, Jia-Yi
   Xia, Yong
   Huang, Jun-Wei
   Wang, Ke
   Ju, Zi-Yong
TI Electroacupuncture intervention relieves pain by stimulating the STING/IFN-I 
SO Molecular pain
LA English
DT Journal Article
DE IFN-I; STING; analgesic effects; cancer-induced bone pain; electroacupuncture
AB This study aimed to evaluate the effects of electroacupuncture (EA) on 
   cancer-induced bone pain (CIBP) and investigate its interaction with the 
   STING/IFN-I pathway. A CIBP model was established in female rats. EA was 
   administered for six consecutive days at bilateral L3-L5 Jia Ji points (EX-B2). 
   EA-induced antinociception was evaluated through mechanical, thermal, and cold 
   sensitivity assessments. EA significantly increased the paw withdrawal threshold 
   (PWT) and paw withdrawal latency (PWL) in rats with CIBP (p < 0.01). In the 
   spinal cord of CIBP model rats, western blot analysis demonstrated that the 
   application of EA upregulated the expression of STING, IRF3, and IFNAR (p < 
   0.05). The ELISA results indicated that EA significantly increased the expression 
   of IFN-α (p < 0.005) and IFN-β (p < 0.01) and reduced the expression of TNF-α and 
   IL-1β (p < 0.05). Immunofluorescence analysis revealed that STING was 
   predominantly localized in microglia, with a minimal presence in neuronal cells. 
   Furthermore, intrathecal administration of the STING antagonist C-176 attenuated 
   the analgesic effects of EA in CIBP (p < 0.05). Both EA and STING agonist were 
   effective in alleviating pain in rats with CIBP, possibly through the activation 
   of the STING/IFN-I pathway. Notably, EA treatment reduced pro-inflammatory 
   cytokines and increased anti-inflammatory cytokines. In contrast, while the STING 
   agonist exhibited analgesic effects, it was associated with elevated levels of 
   pro-inflammatory cytokines. These finding underscore the therapeutic potential of 
   EA in the management of CIBP.
C1 Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
NR 0
TC 0
SN 1744-806
EI 
J9 Mol Pain
PD MAY 7
PY 2025
VL 21
IS 
BP 17448069251342240
EP 17448069251342240
DI 10.1177/17448069251342240 
PG 1
WC Animals; Electroacupuncture; methods; Female; Cancer Pain; therapy; Rats, Sprague-Dawley; Disease Models, Animal; Signal Transduction; Bone Neoplasms; complications; Rats; Membrane Proteins; metabolism
UT PubMed:40331681
PM 40331681
DA 2025-05-07
ER

PT J
AU Li, D
   Sun, RR
   Li, QL
   Ma, Q
   Zeng, YL
   Jia, XZ
   Wang, J
AF Li, Dan
   Sun, Rui-Rui
   Li, Qing-Ling
   Ma, Qiang
   Zeng, Yong-Lei
   Jia, Xue-Zhao
   Wang, Jing
TI [Acupuncture combined with opioid drugs on moderate and severe cancer pain: a 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture; cancer pain; opioid drugs; randomized controlled trial (RCT)
AB OBJECTIVE: To explore the clinical therapeutic effect of acupuncture combined 
   with opioid drugs on moderate and severe cancer pain. METHODS: A total of 60 
   patients with cancer were randomized into an observation group and a control 
   group, 30 cases in each group. Oxycodonehydrochloride prolonged-release tablet 
   was taken orally in the control group. On the basis of the control group, 
   acupuncture was applied at Hegu (LI 4), Neiguan (PC 6), Zusanli (ST 36), 
   Sanyinjiao (SP 6), etc. Corresponding back-shu points, xi-cleft points and ashi 
   points were selected additionally according to primary viscera and pain sites in 
   the observation group. The treatment was given once a day for 2 weeks. 
   Symptomatic and supportive treatment were implanted, and no other antalgic 
   measures were given during the trial. The daily dosage of opioid drug and the 
   adverse reactions were recorded in both groups. Karnofsky performance status 
   (KPS) and quality of life (QOL) scale scores were compared before and after 
   treatment. Numerical rating scale (NRS) score was calculated to evaluate the 
   clinical therapeutic effect. RESULTS: Compared before treatment, the daily dosage 
   of opioid drugs after treatment was obviously reduced in the observation group 
   (P<0.01), and was obviously increased in the control group (P<0.05). The dosage 
   of opioid drugs after treatment in the observation group was much less than the 
   control group (P<0.01). After treatment, the KPS and QOL scores were increased in 
   both groups (P<0.01), and the scores in the observation group were superior to 
   the control group (P<0.01, P<0.05). The analgesic effective rate was 90.0% 
   (27/30) in the observation group, which was superior to 76.7% (23/30) in the 
   control group (P<0.05). The adverse reactions rate in the observation group was 
   lower than the control group (P<0.01). CONCLUSION: Acupuncture combined with 
   opioid drugs can effectively relieve the cancer pain, improve the performance 
   status and quality of life in cancer patients, reduce the dosage of opioid drugs 
   and adverse reactions rate.
C1 Guoyitang Department of Anhui University of CM, Hefei 230038, China.
   Third Affiliated Hospital of Anhui University of CM.
   Graduate School of Anhui University of CM.
   Graduate School of Anhui University of CM.
   Second Affiliated Hospital of Anhui University of CM.
   College of TCM, Anhui University of CM, Hefei 230038.
   College of TCM, Anhui University of CM, Hefei 230038.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD APR 10
PY 2020
VL 40
IS 3
BP 257
EP 61
DI 10.13703/j.0255-2930.20190311-k0001 
PG -196
WC Acupuncture Points; Acupuncture Therapy; Analgesics, Opioid; therapeutic use; Cancer Pain; therapy; Humans; Neoplasms; physiopathology; Quality of Life; Treatment Outcome
UT PubMed:32270637
PM 32270637
DA 2020-04-10
ER

PT J
AU Liang, Y
   Du, JY
   Fang, JF
   Fang, RY
   Zhou, J
   Shao, XM
   Jiang, YL
   Chen, YT
   Fang, JQ
AF Liang, Yi
   Du, Jun-Ying
   Fang, Jun-Fan
   Fang, Ruo-Yi
   Zhou, Jie
   Shao, Xiao-Mei
   Jiang, Yong-Liang
   Chen, Yi-Tian
   Fang, Jian-Qiao
TI Alleviating Mechanical Allodynia and Modulating Cellular Immunity Contribute to 
SO Integrative cancer therapies
LA English
DT Journal Article
DE analgesia; bone cancer pain; cellular immunity; electroacupuncture; mechanical allodynia; morphine; naloxone
AB HYPOTHESIS: Electroacupuncture (EA) has been used as an alternative analgesic 
   therapy for hundreds of years, yet its analgesic potency and therapeutic 
   advantage against bone cancer pain (BCP) in comparison with morphine remains 
   unclear. This study aimed to investigate the effects of EA on mechanical 
   allodynia and cellular immunity of BCP rats, and to further explore the potential 
   mechanism. METHODS: The BCP model was established by implanting Walker 256 
   mammary gland carcinoma cells into the left tibia of adult female Sprague-Dawley 
   rats. EA (dilatational wave, 2/100 Hz, 0.5 mA-1mA-1.5 mA for 10 minutes each 
   intensity) was applied bilaterally to Zusanli (ST 36) and Kunlun (BL 60) for 30 
   minutes. Both EA stimulation and morphine (10 mg/kg, intraperitoneally) was given 
   once every other day. Naloxone (0.3 mg/kg, intraperitoneally) was injected at 30 
   minutes prior to EA. Mechanical allodynia were demonstrated by paw withdrawal 
   thresholds (PWTs) which measured by dynamic plantar aesthesiometer. T cell 
   proliferation, percentage of CD3(+), CD4(+) and CD8(+) T lymphocytes in spleen as 
   well as expression of interleukin-2 (IL-2) in plasma were detected by WST-8, flow 
   cytometry, and enzyme-linked immunosorbent assay technique, respectively. 
   RESULTS: An intratibial inoculation of Walker 256 mammary gland carcinoma cells 
   significantly decreased PWTs to mechanical stimuli. EA stimulation alleviated 
   mechanical allodynia in BCP rats, and the analgesic potency of EA was weaker than 
   that of morphine. In contrast to morphine, EA stimulation of BCP rats increased 
   splenic concanavalin A (Con A)-induced T cell proliferation and plasma IL-2 
   content, as well as increased the percentages of splenic CD(3)(+)CD(4)(+) and 
   CD(3)(+)CD(8)(+) T cell subsets. Moreover, both the analgesic effect and the 
   partial immunomodulation of EA were suppressed by an intraperitoneal injection of 
   naloxone. CONCLUSION: EA could significantly alleviate BCP-induced mechanical 
   allodynia. Although the analgesic effect of EA was weaker than that of morphine, 
   EA had an immunomodulation effect on cellular immunity. Both analgesic and 
   immunomodulatory effect of EA might share the same mechanism via the 
   opioid-mediated pathway, which needs further investigation.
C1 1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
   2 The Third Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 
   1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
   1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
   1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
   2 The Third Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
   1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
   1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
   1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
   1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD SEP 6
PY 2017
VL 17
IS 2
BP 401
EP 410
DI 10.1177/1534735417728335 
PG 9
WC Animals; Bone Neoplasms; immunology; CD3 Complex; immunology; CD4-Positive T-Lymphocytes; immunology; CD8-Positive T-Lymphocytes; immunology; Cancer Pain; immunology; Cell Proliferation; physiology; Electroacupuncture; methods; Female; Humans; Hyperalgesia; immunology; Immunity, Cellular; immunology; Rats; Rats, Sprague-Dawley
UT PubMed:28870114
PM 28870114
DA 2017-09-06
ER

PT J
AU Tack, L
   Lefebvre, T
   Blieck, V
   Cool, L
   Pottel, H
   Eygen, KV
   Derijcke, S
   Vergauwe, P
   Schofield, P
   Chandler, R
   Lane, P
   Boterberg, T
   Debruyne, PR
AF Tack, Laura
   Lefebvre, Tessa
   Blieck, Virginie
   Cool, Lieselot
   Pottel, Hans
   Eygen, Koen Van
   Derijcke, Sofie
   Vergauwe, Philippe
   Schofield, Patricia
   Chandler, Rebecca
   Lane, Pauline
   Boterberg, Tom
   Debruyne, Philip R
TI Acupuncture as a Complementary Therapy for Cancer Care: Acceptability and 
SO Journal of acupuncture and meridian studies
LA English
DT Journal Article
DE Acupuncture; Cancer; Cancerrelated side effect; Complementary therapy; Informal caregiver
AB BACKGROUND: Acupuncture can effectively manage cancer-related side effects, for 
   both patients undergoing treatment and for cancer survivors. It may also be 
   effective in managing physiological and psychological symptoms common among 
   informal caregivers of cancer patients. OBJECTIVES: The aim of this survey was to 
   explore the acceptability and preferences of cancer patients, cancer survivors, 
   and their informal caregivers in relation to acupuncture. METHODS: The survey was 
   conducted from 20(th) November to 27(th) November 2018. The questionnaire was 
   developed to explore acceptability and preferences, including motivation, 
   symptoms to be addressed, and practical issues (location, cost, etc.), in 
   relation to acupuncture. RESULTS: The survey response rate was 94.5% in cancer 
   patients and cancer survivors and 100% in caregivers. Acceptability of 
   acupuncture was 34.5% (n = 40/116) and 48.0% (n = 26/54) in cancer patients and 
   caregivers, respectively. About 52.5% (n = 21/40) of patients preferred to 
   undergo acupuncture at the day center clinic, whereas caregivers had no specific 
   preference. Patients and cancer survivors would use acupuncture for symptoms of 
   fatigue (60%), listlessness (57.5%), and pain (47.5%). Informal caregivers 
   expressed an interest in using acupuncture for their pain, stress, and sleeping 
   difficulties 48.0% (n = 26/54). CONCLUSION: Cancer patients, cancer survivors, 
   and informal caregivers would accept acupuncture as a complementary therapy. This 
   openness and preference to acupuncture provide the foundations for this 
   complementary therapy to be incorporated into holistic and supportive cancer 
   care, both for patients and those supporting them.
C1 Department of Medical Oncology, Kortrijk Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium.
   Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
   Department of Medical Oncology, Kortrijk Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium.
   Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
   College for Traditional Chinese Medicine & Karel de Grote University College, Antwerp, Belgium.
   Department of Medical Oncology, Kortrijk Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium.
   Department of Public Health and Primary Care at Kulak, Catholic University Leuven Kulak, Kortrijk, Belgium.
   Department of Haematology, Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium.
   Department of Pneumology, General Hospital Groeninge, Kortrijk, Belgium.
   Department of Gastro-Enterology, General Hospital Groeninge, Kortrijk, Belgium.
   Sheffield Hallam University, Sheffield, United Kingdom.
   Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Chelmsford, United Kingdom.
   Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Chelmsford, United Kingdom.
   Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
   Department of Medical Oncology, Kortrijk Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium.
   School of Life Sciences, Anglia Ruskin University, Cambridge, United Kingdom.
NR 0
TC 0
SN 2093-815
EI 
J9 J Acupunct Meridian Stud
PD APR 30
PY 2021
VL 14
IS 2
BP 67
EP 74
DI 10.51507/j.jams.2021.14.2.67 
PG 7
WC Acupuncture Therapy; Caregivers; psychology; Humans; Neoplasms; therapy; Pain; Surveys and Questionnaires
UT PubMed:35770541
PM 35770541
DA 2021-04-30
ER

PT J
AU Lee, J
   Yoon, SW
AF Lee, Jinsoo
   Yoon, Seong Woo
TI Efficacy and Safety of Moxibustion for Relieving Pain in Patients With Metastatic 
SO Integrative cancer therapies
LA English
DT Journal Article
DE cancer pain; metastatic cancer; moxibustion; sham moxibustion; true moxibustion
AB BACKGROUND: Moxibustion has been traditionally used to manage pain related to 
   chronic diseases, including cancer. This study aims to investigate the efficacy 
   and safety of moxibustion for relieving cancer pain in patients with metastatic 
   cancer. METHODS: A total of 16 patients were randomly divided into a true 
   moxibustion (TM) group or a sham moxibustion (SM) group. In both groups, 
   moxibustion was applied for 10 minutes, once daily for 7 consecutive days. In the 
   SM group, the moxa cone was removed earlier than in the TM group, so as not to 
   deliver heat stimulation completely into the skin. The changes of pain severity 
   using the Brief Pain Inventory (BPI) and quality of life measured by the 
   Functional Assessment of Cancer Therapy-General (FACT-G) were observed. A 
   blinding credibility test was done to validate the sham moxibustion procedure. 
   RESULTS: The total BPI score significantly decreased in the TM group compared 
   with the SM group (TM vs SM: -0.97 ± 1.05 vs 0.35 ± 0.60,P= .025). The 2 subsets 
   of BPI, pain intensity score and pain interference score, also significantly 
   decreased in the TM group (TM vs SM: intensity, -0.82 ± 0.93 vs 0.46 ± 0.87,P= 
   .020; interference, -1.12 ± 1.31 vs 0.24 ± 0.61,P= .047). Even after adjusting 
   for the values of opioid consumption, these results remained significant. FACT-G 
   did not significantly improve in the TM group. The blinding to sham moxibustion 
   was credible and no serious adverse events occurred. CONCLUSION: We suggest that 
   moxibustion could be a safe and potential modality for cancer-related pain in 
   patients with metastatic cancer. With the limitation of small sample size, a 
   larger and long-term follow-up study is necessary to determine more definitely 
   the efficacy of moxibustion.
C1 Kyung Hee University Korean Medicine Hospital at Gangdong, Seoul, Republic of Korea.
   Kyung Hee University Korean Medicine Hospital at Gangdong, Seoul, Republic of Korea stepano212@hanmail.net.
NR 0
TC 0
SN 1552-695
EI 
J9 Integr Cancer Ther
PD NOV 28
PY 2013
VL 13
IS 3
BP 211
EP 6
DI 10.1177/1534735413510025 
PG -205
WC Adult; Aged; Analgesics, Opioid; administration & dosage; Female; Humans; Male; Middle Aged; Moxibustion; adverse effects; Neoplasm Metastasis; Neoplasms; complications; Pain; etiology; Pain Management; methods; Pain Measurement; Pilot Projects; Quality of Life; Single-Blind Method; Treatment Outcome
UT PubMed:24282101
PM 24282101
DA 2013-11-28
ER

PT J
AU Quinlan-Woodward, J
   Gode, A
   Dusek, JA
   Reinstein, AS
   Johnson, JR
   Sendelbach, S
AF Quinlan-Woodward, Jessica
   Gode, Autumn
   Dusek, Jeffery A
   Reinstein, Adam S
   Johnson, Jill R
   Sendelbach, Sue
TI Assessing the Impact of Acupuncture on Pain, Nausea, Anxiety, and Coping in Women 
SO Oncology nursing forum
LA English
DT Journal Article
DE acupuncture ; anxiety; breast cancer; nausea/vomiting; pain
AB PURPOSE/OBJECTIVES: To compare the effect of acupuncture to a standard-of-care 
   (control) group on pain, nausea, anxiety, and ability to cope.  . DESIGN: Pilot 
   randomized, controlled trial.  . SETTING: Abbott Northwestern Hospital, a large, 
   urban, tertiary care hospital in Minneapolis, Minnesota. . SAMPLE: 30 adult women 
   undergoing surgery for breast cancer. . METHODS: Women were randomly assigned to 
   two hospital-based acupuncture treatments versus usual care after breast cancer 
   surgery. Pain, nausea, anxiety, and the patient's ability to cope pre- and 
   post-treatment were compared within and between groups at two different time 
   points postoperatively.  . MAIN RESEARCH VARIABLES: Mean change in pain, nausea, 
   anxiety, and ability to cope by treatment group. . FINDINGS: Compared to women 
   assigned to the control group, women who received acupuncture reported a 
   statistically significant greater reduction in pain, nausea, anxiety, and 
   increase in ability to cope on the first postoperative day and in pain on the 
   second postoperative day following mastectomy surgery. . CONCLUSIONS: Acupuncture 
   delivered postoperatively in the hospital after mastectomy can reduce the 
   severity of symptoms experienced, as well as increase the patient's ability to 
   cope with her symptoms. However, before implementation as a standard of care, 
   further research needs to be conducted. . IMPLICATIONS FOR NURSING: Acupuncture 
   adds a nonpharmacologic intervention for symptom management in women undergoing 
   mastectomies for breast cancer.
C1 Penny George Institute for Health and Healing.
   Penny George Institute for Health and Healing.
   Penny George Institute for Health and Healing.
   Penny George Institute for Health and Healing.
   Penny George Institute for Health and Healing.
   Abbott Northwestern Hospital.
NR 0
TC 0
SN 1538-068
EI 
J9 Oncol Nurs Forum
PD OCT 22
PY 2016
VL 43
IS 6
BP 725
EP 732
DI 10.1188/16.ONF.725-732 
PG 7
WC Acupuncture Therapy; Adaptation, Psychological; Adult; Aged; Aged, 80 and over; Analgesics; therapeutic use; Anti-Anxiety Agents; therapeutic use; Antiemetics; therapeutic use; Anxiety; etiology; Breast Neoplasms; surgery; Female; Humans; Mastectomy; adverse effects; Middle Aged; Minnesota; Nausea; etiology; Pain, Postoperative; etiology; Pilot Projects
UT PubMed:27768139
PM 27768139
DA 2016-10-22
ER

PT J
AU Maurer, J
   Ambrosini, F
   Chen, Y
   Schroeder, S
AF Maurer, Jean
   Ambrosini, Francesca
   Chen, Yuelai
   Schroeder, Sven
TI Acupuncture: a strategy for pain management among patients with prostate cancer - 
SO BJU international
LA English
DT Letter
C1 Martini-Klinik Prostate Cancer Center, Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
   IRCCS Ospedale Policlinico San Martino, Genova, Italy.
   Longhua Hospital Affiliated to Shanghai University of TCM, Shanghai, China.
   HanseMerkur Center for Traditional Chinese Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
NR 0
TC 0
SN 1464-410
EI 
J9 BJU Int
PD JUL 17
PY 2024
VL 134
IS 4
BP 665
EP 666
DI 10.1111/bju.16468 
PG 1
WC Humans; Male; Prostatic Neoplasms; therapy; Cancer Pain; therapy; Acupuncture Therapy; Pain Management; methods
UT PubMed:39014978
PM 39014978
DA 2024-07-17
ER

PT J
AU Yeh, CH
   Chien, LC
   Chiang, YC
   Ren, D
   Suen, LK
AF Yeh, Chao Hsing
   Chien, Lung-Chang
   Chiang, Yi Chien
   Ren, Dianxu
   Suen, Lorna Kwai-Ping
TI Auricular point acupressure as an adjunct analgesic treatment for cancer 
SO Pain management nursing : official journal of the American Society of Pain 
LA English
DT Journal Article
AB This study aimed (1) to examine the feasibility of an auricular point acupressure 
   (APA) research protocol in terms of recruitment and for the assessment and 
   management of pain and (2) to examine the potential APA analgesic effects for 
   cancer patients. This study was a repeated-measures one-group design. 
   Participants were recruited from the cancer center follow-up clinic affiliated 
   with a large university hospital in the northeastern United States. Participants 
   included 50 patients aged 55-87 years with a diagnosis of cancer. Participants 
   received 7 days of APA treatment for their pain. After appropriate acupoints were 
   identified, vaccaria seeds were carefully taped onto each selected auricular 
   point on each ear. The study recruitment and retention rates were 92% and 91%, 
   respectively. Importantly, the study found preliminary evidence for the analgesic 
   effects of APA for cancer pain management. For example, by the end of the 7-day 
   study, APA reduced pain intensity more than 55% for "worst pain" and about 57% 
   for "average pain" and "pain intensity." Moreover, the use of pain medication was 
   reduced during the APA treatment (e.g., 78% of patients [n = 39] took less pain 
   medication than before the treatment). APA appears to be highly acceptable to 
   patients with cancer-related pain. However, without a placebo control, we cannot 
   draw conclusive evidence for the analgesic effect of APA for cancer patients. A 
   sham group must be added to future studies to differentiate the true effects of 
   APA from the possible psychological effects of the APA treatment.
C1 School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania.
   Division of Biostatistics, University of Texas School of Public Health at San Antonio Regional Campus, San Antonio, Texas
   Research to Advance Community HealthCenter, University of Texas Health Science Center at San Antonio Regional Campus,San Antonio, Texas.
   Department of Nursing, Chang Gung University of Science and Technology, Tao-Yuen, Taiwan. 
   School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania.
   School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
EM ycchiang@gw.cgust.edu.tw
NR 0
TC 0
SN 1532-863
EI 
J9 Pain Manag Nurs
PD DEC 3
PY 2014
VL 16
IS 3
BP 285
EP 93
DI 10.1016/j.pmn.2014.08.005 
PG -192
WC Acupressure; Acupuncture Analgesia; methods; Acupuncture Points; Aged; Aged, 80 and over; Analgesics; therapeutic use; Cancer Pain; prevention & control; Combined Modality Therapy; Feasibility Studies; Female; Humans; Male; Middle Aged; Pain Measurement; Patient Satisfaction
UT PubMed:25439120
PM 25439120
DA 2014-12-03
ER

PT J
AU García, Espinosa MV
   Prieto, Checa I
AF García Espinosa, María Victoria
   Prieto Checa, Isabel
TI [Non-oncologic chronic pain: Where we are and where we want to go].
SO Atencion primaria
LA spa
DT Editorial
C1 Medicina Familiar y Comunitaria, Centro de Salud Los Alpes, Madrid, España. 
   Medicina Familiar y Comunitaria, Centro de Salud Los Alpes, Madrid, España.
EM vgespinosa@gmail.com
NR 0
TC 0
SN 1578-127
EI 0212-656
J9 Aten Primaria
PD MAY 8
PY 2018
VL 50
IS 9
BP 517
EP 518
DI 10.1016/j.aprim.2017.12.006 
PG 1
WC Acupuncture Therapy; Chronic Pain; drug therapy; Humans; Mind-Body Therapies; Opioid-Related Disorders; etiology; Pain Management; adverse effects; Prescription Drug Overuse; mortality; Spain
UT PubMed:29735179
PM 29735179
DA 2018-05-08
ER

PT J
AU Li, X
   Zhi, L
   Han, KY
   Li, SQ
   Ahmad, K
   Seluzicki, C
   Wang, R
   Bao, T
AF Li, Xiaotong
   Zhi, Lilly
   Han, Katherine Y
   Li, Susan Q
   Ahmad, Khalada
   Seluzicki, Christina
   Wang, Rui
   Bao, Ting
TI Impact of Baseline Expectancy on Outcome Prediction of Real and Sham Acupuncture 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; acupuncture expectancy; chemotherapy-induced peripheral neuropathy; pain; sham acupuncture
AB BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) pain significantly 
   worsens cancer survivors' quality of life. Expectancy may play an important role 
   in acupuncture response. We sought to explore whether expectancy predicts pain 
   outcome in real acupuncture (RA) and sham acupuncture (SA) in cancer survivors. 
   METHODS: We analyzed data from a randomized clinical trial that evaluated the 
   effect of RA on CIPN symptoms compared to SA and wait list control (WLC) in 75 
   cancer survivors. This secondary analysis was limited to CIPN pain measured by 
   the Numeric Rating Scale (NRS), graded from 0 to 10. Interventions were delivered 
   over 8 weeks. SA was implemented using a combination of non-acupuncture points 
   and a non-insertion procedure. Patient expectancy was measured by the Acupuncture 
   Expectancy Scale (AES) 3 times during the study. We used a linear regression 
   model to evaluate if the NRS score was associated with the baseline AES score at 
   the end of treatment (week 8), adjusting for baseline NRS score. RESULTS: AES was 
   similar among 3 groups at baseline (RA: 11.8 ± 2.7; SA: 12.1 ± 3.8.; WLC: 
   14.6 ± 4.2; P = .062). Baseline AES was not found to be significantly associated 
   with the week 8 NRS score among patients in all RA, SA, and WLC groups (all 
   P > .05). However, we found a trend that higher baseline AES predicted lower NRS 
   score at week 8 in the SA group: a one-point higher score on baseline expectancy 
   was associated with a 0.3-point reduction in NRS pain score (P = .059) at week 8. 
   CONCLUSIONS: The association of baseline expectancy and acupuncture response was 
   similar between RA and SA. However, SA seemed to rely more on expectancy than RA. 
   Further studies with larger sample sizes are needed to confirm this finding.
C1 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Ward Melville High School, East Setauket, NY, USA.
   Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   AdventHealth Cancer Institute Clinical Research, AdventHealth Great Lakes Region, Hinsdale, IL, USA.
   Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Memorial Sloan Kettering Cancer Center, New York, NY, USA.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD JAN 25
PY 2023
VL 22
IS 
BP 15347354221149992
EP 15347354221149992
DI 10.1177/15347354221149992 
PG 1
WC Humans; Quality of Life; Acupuncture Therapy; methods; Pain; Peripheral Nervous System Diseases; chemically induced; Neoplasms; Cancer Survivors; Antineoplastic Agents; adverse effects; Treatment Outcome
UT PubMed:36691937
PM 36691937
DA 2023-01-25
ER

PT J
AU Liu, W
   Qdaisat, A
   Lopez, G
   Narayanan, S
   Underwood, S
   Spano, M
   Reddy, A
   Guo, Y
   Yeung, SC
   Bruera, E
   Cohen, L
AF Liu, Wenli
   Qdaisat, Aiham
   Lopez, Gabriel
   Narayanan, Santhosshi
   Underwood, Susan
   Spano, Michael
   Reddy, Akhila
   Guo, Ying
   Yeung, Sai-Ching
   Bruera, Eduardo
   Cohen, Lorenzo
TI Association Between Acupoint Selection, Target Symptoms, and Traditional Chinese 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; acupuncture point selection; cancer; complementary health approaches; integrative medicine; traditional Chinese medicine
AB Background: Acupuncture intervention in actual practice is rarely reported and 
   may be different from that applied in acupuncture research. Objectives: To review 
   acupuncture practice in an integrative medicine clinic and characterize the 
   association between targeted symptoms, traditional Chinese medicine (TCM) 
   diagnosis, and acupoint selection. Methods: We reviewed outpatient acupuncture 
   records from March 2016 to April 2018. Statistical analyses were applied to 
   characterize referral symptoms and associated TCM diagnosis as well as acupoint 
   selection. Results: The final analysis included 5393 acupuncture records (1264 
   patients). Twelve TCM diagnosis components were identified in the referral 
   symptoms of pain, neuropathy, xerostomia, and hot flashes. Pain was associated 
   with 78 different TCM diagnoses (combinations of TCM diagnosis components). Total 
   of 217 different acupoints were used in the acupuncture treatments (1739) for 
   neuropathy. The acupoint yintang was used in 73.8% of the visits for neuropathy, 
   yet only in 26.5% (P < .001) of the treatments when patients had a TCM diagnosis 
   of qi deficiency, qi stagnation, and blood stagnation. Similarly, both 
   consistencies and variations were seen in acupoint selection with each targeted 
   symptom and its associated TCM diagnoses. Conclusions: TCM diagnosis was not 
   homogeneous among acupuncture treatments for a single referral symptom. In 
   contrast to most of the research on acupuncture for symptom control, there were 
   considerable variations in acupoint selection among treatments for the same 
   symptom in a clinical setting. Future research is needed to examine the clinical 
   relevance of a fixed intervention structure in acupuncture research and the value 
   of individualized acupuncture treatment.
C1 The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD JUN 9
PY 2020
VL 19
IS 
BP 1534735420928490
EP 1534735420928490
DI 10.1177/1534735420928490 
PG 1
WC Acupuncture; Acupuncture Points; Acupuncture Therapy; Hot Flashes; Humans; Medicine, Chinese Traditional; Neoplasms; diagnosis
UT PubMed:32508209
PM 32508209
DA 2020-06-09
ER

PT J
AU Chan, K
   Lui, L
   Yu, K
   Lau, K
   Lai, M
   Lau, W
   Ng, B
   Zhong, LLD
   Bian, ZX
AF Chan, Kaiyin
   Lui, Louisa
   Yu, Kaling
   Lau, Kwongwai
   Lai, Manchi
   Lau, Waiwai
   Ng, Bacon
   Zhong, Linda L D
   Bian, Zhao-Xiang
TI The efficacy and safety of electro-acupuncture for alleviating 
SO Trials
LA English
DT Journal Article
DE Acupuncture; Chemotherapy-induced peripheral neuropathy; Colorectal cancer; Oxaliplatin
AB BACKGROUND: Colorectal cancer is the most common cancer in Hong Kong. 
   Oxaliplatin-based chemotherapy is a major first-line conventional therapy for 
   advanced and metastatic colorectal cancer. However, oxaliplatin causes 
   chemotherapy-induced peripheral neuropathy (CIPN). Acupuncture has long been used 
   to alleviate limb numbness in Chinese medicine. This study aims to examine the 
   efficacy and safety of acupuncture for alleviating CIPN in patients with 
   colorectal cancer in Hong Kong. METHODS/DESIGN: This is a single-blinded, 
   randomized, sham-controlled efficacy trial. Eighty-four eligible patients, who 
   are Hong Kong Chinese, aged ≥ 18 years, diagnosed with colorectal cancer and 
   undergoing oxaliplatin-based chemotherapy, will be randomized in a ratio of 1:1 
   to the electro-acupuncture group or the sham-controlled group. During a 12-week 
   treatment period, patients in the electro-acupuncture group will undergo 
   electro-acupuncture once a week from the first cycle of chemotherapy, while 
   patients in the control group will receive sham acupuncture, and the patients in 
   both groups will be followed up for 12 weeks. The primary outcome measure is the 
   Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity 
   (FACT/GOC-Ntx) questionnaire. The secondary outcome measures include numerical 
   rating scale (NRS) for numbness/pain, vibration and light touch sense test, the 
   European Organization for Research and Treatment of Cancer Quality of Life 
   Questionnaire-C30 (EORTC QLQ-C30) and Constitution of Chinese Medicine 
   Questionnaire (CCMQ). DISCUSSION: The study will compare electro-acupuncture with 
   sham acupuncture to explore the feasibility for electro-acupuncture in improving 
   symptoms caused by chemotherapy-induced peripheral neuropathy. TRIAL 
   REGISTRATION: Clinicaltrials.gov, NCT03582423. Registered on 11 July 2018.
C1 Yan Chai Hospital cum Hong Kong Baptist University Chinese Medicine Clinic cum Training and Research Centre, Ha Kwai Chung, Hong Kong SAR.
   Oncology Department of Princess Margaret Hospital, Kwai Chung, Hong Kong SAR.
   Yan Chai Hospital cum Hong Kong Baptist University Chinese Medicine Clinic cum Training and Research Centre, Ha Kwai Chung, Hong Kong SAR.
   Yan Chai Hospital cum Hong Kong Baptist University Chinese Medicine Clinic cum Training and Research Centre, Ha Kwai Chung, Hong Kong SAR.
   Yan Chai Hospital cum Hong Kong Baptist University Chinese Medicine Clinic cum Training and Research Centre, Ha Kwai Chung, Hong Kong SAR.
   Yan Chai Hospital cum Hong Kong Baptist University Chinese Medicine Clinic cum Training and Research Centre, Ha Kwai Chung, Hong Kong SAR.
   Chinese Medicine Department, Hong Kong Hospital Authority, Kowloon, Hong Kong SAR.
   Hong Kong Chinese Medicine Clinical Study Centre, Hong Kong Baptist University, Jockey Club School of Chinese Building, 7 Baptist Road, Kowloon Tong, Hong KongSAR. ldzhong@hkbu.edu.hk.
   School of Chinese Medicine, Hong Kong Baptist University, Jockey Club School of 
   Hong Kong Chinese Medicine Clinical Study Centre, Hong Kong Baptist University, Jockey Club School of Chinese Building, 7 Baptist Road, Kowloon Tong, Hong KongSAR. bzxiang@hkbu.edu.hk.
   School of Chinese Medicine, Hong Kong Baptist University, Jockey Club School of 
NR 0
TC 0
SN 1745-621
EI 
J9 Trials
PD JAN 11
PY 2020
VL 21
IS 1
BP 58
EP 58
DI 10.1186/s13063-019-3972-5 
PG 0
WC Antineoplastic Agents; adverse effects; Colorectal Neoplasms; drug therapy; Electroacupuncture; adverse effects; Humans; Outcome Assessment, Health Care; Peripheral Nervous System Diseases; chemically induced; Randomized Controlled Trials as Topic; Single-Blind Method
UT PubMed:31918748
PM 31918748
DA 2020-01-11
ER

PT J
AU Windmill, J
   Fisher, E
   Eccleston, C
   Derry, S
   Stannard, C
   Knaggs, R
   Moore, RA
AF Windmill, Jude
   Fisher, Emma
   Eccleston, Christopher
   Derry, Sheena
   Stannard, Cathy
   Knaggs, Roger
   Moore, R Andrew
TI Interventions for the reduction of prescribed opioid use in chronic non-cancer 
SO The Cochrane database of systematic reviews
LA English
DT Journal Article
AB BACKGROUND: Patients with chronic non-cancer pain who are prescribed and are 
   taking opioids can have a history of long term high dose opioid use without 
   effective pain relief. In those without good pain relief, reduction of prescribed 
   opioid dose may be the desired and shared goal of both patient and clinician. 
   Simple unsupervised reduction of opioid use is clinically challenging, and very 
   difficult to achieve and maintain. OBJECTIVES: To investigate the effectiveness 
   of different methods designed to achieve reduction or cessation of prescribed 
   opioid use for the management of chronic non-cancer pain. SEARCH METHODS: We 
   searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, 
   and EMBASE from inception to 8th April 2013, as well as bibliographies. SELECTION 
   CRITERIA: Included studies had to be randomised controlled trials comparing 
   opioid users receiving an intervention with a control group receiving treatment 
   as usual, active control, or placebo. The aim of the study had to include a 
   treatment goal of dose reduction or cessation of opioid medication. DATA 
   COLLECTION AND ANALYSIS: We sought data relating to prescribed opioid use, 
   adverse events of opioid reduction, pain, and psychological and physical 
   function. MAIN RESULTS: Two studies provided information on 86 participants. One 
   compared electroacupuncture with sham acupuncture for 20 minutes twice a week for 
   six weeks; there was no difference between treatments. The other followed 11 
   weeks of cognitive behavioural therapy with either therapeutic interactive voice 
   response through a computer for four months or usual treatment; the active group 
   had a significant reduction in opioid use, while the usual care group had a 
   significant increase. AUTHORS' CONCLUSIONS: Both included studies were at 
   significant risk of bias because of their small size, together with other 
   important issues, including blinding. Because of this risk and the paucity of 
   relevant studies, no conclusions can be drawn regarding the effectiveness of 
   interventions for opioid withdrawal in chronic non-cancer pain.
C1 Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Churchill Hospital, Oxford, UK, OX3 7LE.
NR 0
TC 0
SN 1469-493
EI 
J9 Cochrane Database Syst Rev
PD SEP 3
PY 2013
VL 0
IS 9
BP CD010323
EP CD010323
DI 10.1002/14651858.CD010323.pub2 
PG 1
WC Analgesics, Opioid; administration & dosage; Chronic Pain; drug therapy; Cognitive Behavioral Therapy; methods; Drug Tolerance; Electroacupuncture; methods; Humans; Observational Studies as Topic; Randomized Controlled Trials as Topic; Therapy, Computer-Assisted; methods
UT PubMed:23996347
PM 23996347
DA 2013-09-03
ER

PT J
AU Eccleston, C
   Fisher, E
   Thomas, KH
   Hearn, L
   Derry, S
   Stannard, C
   Knaggs, R
   Moore, RA
AF Eccleston, Christopher
   Fisher, Emma
   Thomas, Kyla H
   Hearn, Leslie
   Derry, Sheena
   Stannard, Cathy
   Knaggs, Roger
   Moore, R Andrew
TI Interventions for the reduction of prescribed opioid use in chronic non-cancer 
SO The Cochrane database of systematic reviews
LA English
DT Journal Article
AB BACKGROUND: This is the first update of the original Cochrane Review published in 
   2013. The conclusions of this review have not changed from the 2013 publication. 
   People with chronic non-cancer pain who are prescribed and are taking opioids can 
   have a history of long-term, high-dose opioid use without effective pain relief. 
   In those without good pain relief, reduction of prescribed opioid dose may be the 
   desired and shared goal of both patient and clinician. Simple, unsupervised 
   reduction of opioid use is clinically challenging, and very difficult to achieve 
   and maintain. OBJECTIVES: To investigate the effectiveness of different methods 
   designed to achieve reduction or cessation of prescribed opioid use for the 
   management of chronic non-cancer pain in adults compared to controls. SEARCH 
   METHODS: For this update we searched CENTRAL, MEDLINE, and Embase in January 
   2017, as well as bibliographies and citation searches of included studies. We 
   also searched one trial registry for ongoing trials. SELECTION CRITERIA: Included 
   studies had to be randomised controlled trials comparing opioid users receiving 
   an intervention with a control group receiving treatment as usual, active 
   control, or placebo. The aim of the study had to include a treatment goal of dose 
   reduction or cessation of opioid medication. DATA COLLECTION AND ANALYSIS: Two 
   review authors independently extracted data and assessed risk of bias. We sought 
   data relating to prescribed opioid use, adverse events of opioid reduction, pain, 
   and psychological and physical function. We planned to assess the certainty of 
   the evidence using the GRADE approach, however, due to the heterogeneity of 
   studies, we were unable to combine outcomes in a meta-analysis and therefore we 
   did not assess the evidence with GRADE. MAIN RESULTS: Three studies are new to 
   this update, resulting in five included studies in total (278 participants). 
   Participants were primarily women (mean age 49.63 years, SD = 11.74) with 
   different chronic pain conditions. We judged the studies too heterogeneous to 
   pool data in a meta-analysis, so we have summarised the results from each study 
   qualitatively. The studies included acupuncture, mindfulness, and cognitive 
   behavioral therapy interventions aimed at reducing opioid consumption, misuse of 
   opioids, or maintenance of chronic pain management treatments. We found mixed 
   results from the studies. Three of the five studies reported opioid consumption 
   at post-treatment and follow-up. Two studies that delivered 'Mindfulness-Oriented 
   Recovery Enhancement' or 'Therapeutic Interactive Voice Response' found a 
   significant difference between groups at post-treatment and follow-up in opioid 
   consumption. The remaining study found reduction in opioid consumption in both 
   treatment and control groups, and between-group differences were not significant. 
   Three studies reported adverse events related to the study and two studies did 
   not have study-related adverse events. We also found mixed findings for pain 
   intensity and physical functioning. The interventions did not show between-group 
   differences for psychological functioning across all studies. Overall, the risk 
   of bias was mixed across studies. All studies included sample sizes of fewer than 
   100 and so we judged all studies as high risk of bias for that category. AUTHORS' 
   CONCLUSIONS: There is no evidence for the efficacy or safety of methods for 
   reducing prescribed opioid use in chronic pain. There is a small number of 
   randomised controlled trials investigating opioid reduction, which means our 
   conclusions are limited regarding the benefit of psychological, pharmacological, 
   or other types of interventions for people with chronic pain trying to reduce 
   their opioid consumption. The findings to date are mixed: there were reductions 
   in opioid consumption after intervention, and often in control groups too.
C1 Centre for Pain Research, University of Bath, Claverton Down, Bath, UK.
NR 0
TC 0
SN 1469-493
EI 
J9 Cochrane Database Syst Rev
PD NOV 14
PY 2017
VL 11
IS 11
BP CD010323
EP CD010323
DI 10.1002/14651858.CD010323.pub3 
PG 1
WC Analgesics, Opioid; administration & dosage; Chronic Pain; drug therapy; Cognitive Behavioral Therapy; methods; Drug Tolerance; Electroacupuncture; methods; Female; Humans; Male; Middle Aged; Mindfulness; Observational Studies as Topic; Randomized Controlled Trials as Topic; Therapy, Computer-Assisted; methods
UT PubMed:29130474
PM 29130474
DA 2017-11-14
ER

PT J
AU Zhi, WI
   Baser, RE
   Talukder, D
   Mei, YZ
   Harte, SE
   Bao, T
AF Zhi, W Iris
   Baser, Raymond E
   Talukder, Dristi
   Mei, Ying Zi
   Harte, Steven E
   Bao, Ting
TI Mechanistic and thermal characterization of acupuncture for chemotherapy-induced 
SO Breast cancer research and treatment
LA English
DT Journal Article
DE Acupuncture; Breast cancer; Chemotherapy; Neuropathy; Quantitative sensory testing; Sensory loss
AB PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and 
   debilitating side effect of chemotherapy. Acupuncture is a promising 
   non-pharmacological intervention for CIPN. However, the physiological effects of 
   acupuncture treatment remain poorly understood. We examined the effects of 
   acupuncture on CIPN using semi-objective quantitative sensory testing (QST). 
   METHODS: We conducted a randomized controlled trial of real acupuncture (RA) and 
   sham acupuncture (SA) compared to usual care (UC) in cancer survivors with 
   moderate-to-severe CIPN. Treatment response was assessed with QST measures of 
   tactile and vibration detection thresholds in hands and feet, thermal detection, 
   and pain thresholds at weeks 0, 8, and 12. Constrained linear mixed model (cLMM) 
   regression was used for statistical analysis. RESULTS: 63 patients completed QST 
   testing. At week 8, vibrational detection thresholds in feet were significantly 
   lower in RA and SA (p = 0.019 and p = 0.046) than in UC, with no difference 
   between RA and SA (p = 0.637). Both RA and SA also showed significantly higher 
   cool thermal detection than UC (p = 0.008 and p = 0.013, respectively), with no 
   difference between RA and SA (p = 0.790). No differences in tactile detection, 
   vibrational detection in hands, warm thermal detection, and thermal pain 
   thresholds were detected among the three arms at weeks 8 and 12. CONCLUSION: QST 
   demonstrated different patterns in RA, SA, and UC. After eight weeks of RA, we 
   observed significant improvements in the vibrational detection threshold in feet 
   and cool thermal detection threshold in hands compared to UC. No significant 
   differences were seen when compared to SA. TRIAL REGISTRATION: ClinicalTrials.gov 
   (NCT03183037); June 9, 2017.
C1 Breast Medicine Service, Department of Medicine, Solid Tumor Division, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Epidemiology and Biostatistics, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Barnard College, Columbia University, New York, NY, USA.
   Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. baot@mskcc.org.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering 
NR 0
TC 0
SN 1573-721
EI 0167-680
J9 Breast Cancer Res Treat
PD DEC 18
PY 2022
VL 197
IS 3
BP 535
EP 545
DI 10.1007/s10549-022-06846-3 
PG 10
WC Humans; Female; Breast Neoplasms; drug therapy; Peripheral Nervous System Diseases; chemically induced; Acupuncture Therapy; adverse effects; Pain Threshold; Antineoplastic Agents; adverse effects
UT PubMed:36527520
PM 36527520
DA 2022-12-18
ER

PT J
AU Liu, CJ
   Chen, ZH
   Li, SJ
   Ren, H
   Hu, XY
   Ren, YL
AF Liu, Cai-Jiao
   Chen, Zhi-Han
   Li, Si-Jing
   Ren, Huan
   Hu, Xiao-Yu
   Ren, Yu-Lan
TI [Visual analysis of research hotspots and frontiers on randomized controlled 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture and moxibustion; research frontiers; research hotspots; visual analysis
AB Retrieved the literature on randomized controlled trials (RCT) of acupuncture and 
   moxibustion from 2011 to 2020 in the Web of Science (WOS) database, and explored 
   research hotspots and frontiers in the field of acupuncture and moxibustion by 
   visually analyze to countries, institutions, authors, keywords, cited literature, 
   etc. using CiteSpace V5.6.R2. A total of 1147 articles were included. China has 
   the largest number of publications, and the top 3 publications are Beijing 
   University of Chinese Medicine, Capital Medical University and Kyung Hee 
   University. The hot research interventions in acupuncture and moxibustion include 
   acupuncture, electroacupuncture, and bee acupuncture. The hot research topics 
   include nerve regeneration, spasms, nausea, pain, obesity, cancer, etc. The 
   research frontiers include acupuncture analgesia, diversification of acupuncture 
   and its clinical effects, brain effects of acupuncture and acupuncture clinical 
   mechanisms. It is believed that the cooperation between countries and 
   institutions should be strengthened in the future, and deeper research should be 
   carried out on the research content that is both hot spot and frontier.
C1 College of Acupuncture- Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   College of Acupuncture- Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   College of Acupuncture- Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   College of Acupuncture- Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   College of Acupuncture- Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
   College of Acupuncture- Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD FEB 14
PY 2022
VL 42
IS 2
BP 221
EP 6
DI 10.13703/j.0255-2930.20201221-k0001 
PG -215
WC Acupuncture; Acupuncture Therapy; Animals; Electroacupuncture; Moxibustion; Randomized Controlled Trials as Topic
UT PubMed:35152591
PM 35152591
DA 2022-02-14
ER

PT J
AU Mao, JJ
   Xie, SX
   Farrar, JT
   Stricker, CT
   Bowman, MA
   Bruner, D
   DeMichele, A
AF Mao, Jun J
   Xie, Sharon X
   Farrar, John T
   Stricker, Carrie T
   Bowman, Marjorie A
   Bruner, Deborah
   DeMichele, Angela
TI A randomised trial of electro-acupuncture for arthralgia related to aromatase 
SO European journal of cancer (Oxford, England : 1990)
LA English
DT Journal Article
DE Acupuncture; Adverse effects; Aromatase inhibitors; Breast neoplasm; Clinical trial; Joint pain; Musculoskeletal
AB BACKGROUND: Arthralgia is a common and debilitating side-effect experienced by 
   breast cancer patients receiving aromatase inhibitors (AIs) and often results in 
   premature drug discontinuation. METHODS: We conducted a randomised controlled 
   trial of electro-acupuncture (EA) as compared to waitlist control (WLC) and sham 
   acupuncture (SA) in postmenopausal women with breast cancer who self-reported 
   arthralgia attributable to AIs. Acupuncturists performed 10 EA/SA treatments over 
   8 weeks using a manualised protocol with 2 Hz electro-stimulation delivered by a 
   TENS unit. Acupuncturists administered SA using Streitberger (non-penetrating) 
   needles at non-traditional acupuncture points without electro-stimulation. The 
   primary end-point was pain severity by Brief Pain Inventory (BPI) between EA and 
   WLC at Week 8; durability of response at Week 12 and comparison of EA to SA were 
   secondary aims. FINDINGS: Of the 67 randomly assigned patients, mean reduction in 
   pain severity was greater in the EA group than in the WLC group at Week 8 (-2.2 
   versus -0.2, p=0.0004) and at Week 12 (-2.4 versus -0.2, p<0.0001). Pain-related 
   interference measured by BPI also improved in the EA group compared to the WLC 
   group at both Week 8 (-2.0 versus 0.2, p=0.0006) and Week 12 (-2.1 versus -0.1, 
   p=0.0034). SA produced a magnitude of change in pain severity and pain-related 
   interference at Week 8 (-2.3, -1.5 respectively) and Week 12 (-1.7, -1.3 
   respectively) similar to that of EA. Participants in both EA and SA groups 
   reported few minor adverse events. INTERPRETATIONS: Compared to usual care, EA 
   produced clinically important and durable improvement in arthralgia related to 
   AIs in breast cancer patients, and SA had a similar effect. Both EA and SA were 
   safe.
C1 Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, PA, United States
   Center for ClinicalEpidemiology and Biostatistics and Department of Biostatistics and Epidemiology,Perelman School of Medicine at the University of Pennsylvania, PA, United States;Abramson Cancer Center, Perelman School of Medicine at the University ofPennsylvania, PA, United States. 
   Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University ofPennsylvania, PA, United States.
   Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University ofPennsylvania, PA, United States
   Abramson Cancer Center, Perelman School ofMedicine at the University of Pennsylvania, PA, United States.
   Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, PA, United States.
   Wright State University School of Medicine, United States.
   Emory University School of Nursing, United States.
   Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University ofPennsylvania, PA, United States
   Abramson Cancer Center, Perelman School ofMedicine at the University of Pennsylvania, PA, United States.
EM jun.mao@uphs.upenn.edu
NR 0
TC 0
SN 1879-085
EI 0959-804
J9 Eur J Cancer
PD NOV 12
PY 2013
VL 50
IS 2
BP 267
EP 76
DI 10.1016/j.ejca.2013.09.022 
PG -191
WC Acupuncture Points; Adult; Aged; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Double-Blind Method; Electroacupuncture; methods; Female; Humans; Middle Aged; Pain Measurement; methods; Time Factors; Treatment Outcome; Waiting Lists
UT PubMed:24210070
PM 24210070
DA 2013-11-12
ER

PT J
AU Duzova, US
   Can, G
   Duzova, M
   Basaran, H
   Yavas, C
AF Duzova, Ulku Saygili
   Can, Gulbeyaz
   Duzova, Mursel
   Basaran, Hamit
   Yavas, Cagdas
TI The effect of acupressure on anxiety, depression, pain, and vital signs in 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupressure; Anxiety; Brachytherapy; Depression; Gynecological cancer; Pain
AB PURPOSE: This study aimed to evaluate the effects of acupressure on pain, 
   anxiety, depression, and physiological parameters in women undergoing 
   brachytherapy for gynecological cancer. METHODS: The research was conducted 
   between December 2023 and September 2024 using a randomized controlled design. 
   All patients receiving brachytherapy were randomly assigned to the acupressure 
   group (n = 40) or the control group (n = 40). In addition to standard clinical 
   care, the acupressure group received manual acupressure for 30 min before each 
   brachytherapy session at specific acupressure points (SP6, PC6, LI4, HT7, LV4). 
   The data were collected using the Personal Information Form, Visual Analog Scale 
   (VAS), State-Trait Anxiety Inventory (STAI-I), Hospital Anxiety and Depression 
   Scale (HADS), and Vital Signs Form. RESULTS: The groups were comparable in terms 
   of sociodemographic and clinical characteristics (p > 0.05). Significant 
   reductions were observed in anxiety, depression, and pain levels in the 
   acupressure group at post-test compared to baseline and the control group 
   (p < 0.001). Additionally, diastolic blood pressure and body temperature 
   significantly decreased in the intervention group (p < 0.001), whereas no 
   significant differences were found for pulse and respiratory rate (p > 0.05). 
   CONCLUSION: The results obtained from this study suggest that acupressure may be 
   a beneficial complementary method for reducing anxiety, depression, and pain, as 
   well as contributing to the regulation of certain physiological parameters in 
   patients undergoing brachytherapy. These findings indicate that acupressure could 
   be considered an intervention that may be integrated into clinical practice to 
   support psychological and physiological well-being. TRIAL REGISTRATION: 
   NCT06531551. Date of Registration: 1 August 2024.
C1 Faculty of Nursing, Selcuk University, Konya, Turkey. ulkusaygili@selcuk.edu.tr.
   Florence Nightingale Nursing Faculty, Istanbul University Cerrahpaşa, Istanbul, Turkey.
   Department of Radiation Oncology, Faculty of Medicine, Selcuk University, Konya, Turkey.
   Department of Radiation Oncology, Faculty of Medicine, Selcuk University, Konya, Turkey.
   Department of Radiation Oncology, Faculty of Medicine, Selcuk University, Konya, Turkey.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD JUL 18
PY 2025
VL 33
IS 8
BP 698
EP 698
DI 10.1007/s00520-025-09754-6 
PG 0
WC Humans; Female; Brachytherapy; adverse effects; Acupressure; methods; Anxiety; therapy; Genital Neoplasms, Female; radiotherapy; Middle Aged; Depression; therapy; Vital Signs; Adult; Pain Measurement; Aged
UT PubMed:40679634
PM 40679634
DA 2025-07-18
ER

PT J
AU Zou, X
   Chen, ZY
   Yang, YH
   Qiao, Y
   He, SJ
   Li, Q
   Chen, WL
   Zhang, XY
   Li, SY
   Sha, SY
   Hu, MH
   Zhang, XY
   Yang, MJ
   Wang, RP
   Wu, HG
   Shi, Y
   Xue, XH
   Ji, YJ
AF Zou, Xuan
   Chen, Zi-Yi
   Yang, Yu-Han
   Qiao, Yu
   He, Shu-Jin
   Li, Qiong
   Chen, Wei-Li
   Zhang, Xin-Yue
   Li, Si-Yu
   Sha, Shan-Yan
   Hu, Min-Hao
   Zhang, Xi-Yin
   Yang, Ming-Ju
   Wang, Rui-Ping
   Wu, Huan-Gan
   Shi, Yin
   Xue, Xiao-Hong
   Ji, Ya-Jie
TI Acupoint Thread Embedding Combined With Wenshen Bugu Decoction for the Treatment 
SO Integrative cancer therapies
LA English
DT Journal Article
DE Wenshen Bugu Decoction; acupoint thread embedding (ATE); aromatase inhibitor-associated musculoskeletal symptom (AIMSS); breast cancer; endocrine therapy
AB BACKGROUND: Aromatase inhibitors (AIs) are recommended as the preferred therapy 
   for postmenopausal women with hormone receptor-positive (HR+) breast cancer. As a 
   result, aromatase inhibitor-associated musculoskeletal symptom (AIMSS) have 
   become a major problem leading to therapy discontinuation and decreased quality 
   of life in patients receiving adjuvant AIs treatment. Multiple therapies have 
   been attempted, but have yielded limited clinical results. This study will be 
   performed to determine whether acupoint thread embedding (ATE) combined with 
   Wenshen Bugu Decoction can effectively treat AIMSS, so as to improve the AIs 
   medication compliance of postmenopausal breast cancer patients. METHODS: This 
   study will utilize a randomized, 2 parallel groups controlled trial design. A 
   total of 128 eligible postmenopausal breast cancer women with AIMSS will be 
   randomized to receive a 12-week treatment with Wenshen Bugu Decoction alone 
   (control group) or in combination with ATE (treatment group) in a 1:1 ratio. The 
   primary outcome will be the 12 week Brief Pain Inventory Worst Pain (BPI-WP) 
   score. The secondary outcome measures will include response rate, Brief Pain 
   Inventory-Short Form (BFI-SF), Western Ontario and McMaster Universities 
   Osteoarthritis Index (WOMAC), Functional Assessment of Cancer Therapy-Endocrine 
   Symptom (FACT-ES), Functional Assessment of Cancer Therapy-Breast (FACT-B), bone 
   marrow density (BMD), blood markers of bone metabolite, Morisky medication 
   adherence scale-8 (MMAS-8), credibility and expectancy, and survival outcomes. 
   DISCUSSION: This trial may provide clinical evidence that ATE combined with 
   Wenshen Bugu Decoction can be beneficial for treating AIMSS among postmenopausal 
   breast cancer survivors. Our findings will be helpful to enhance the quality of 
   life and reduce the occurrence of AIs withdrawal.
C1 Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Tongji University, Shanghai, China.
   Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
   Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD AUG 11
PY 2023
VL 22
IS 
BP 15347354231188679
EP 15347354231188679
DI 10.1177/15347354231188679 
PG 1
WC Humans; Female; Aromatase Inhibitors; adverse effects; Breast Neoplasms; drug therapy; Quality of Life; Acupuncture Points; Postmenopause; Pain; drug therapy; Randomized Controlled Trials as Topic
UT PubMed:37565358
PM 37565358
DA 2023-08-11
ER

PT J
AU Chen, H
   Wu, WY
   Xie, ZM
   Yang, Z
   Yang, B
   Tang, DX
AF Chen, Hui
   Wu, Wen-Yu
   Xie, Zhen-Ming
   Yang, Zhu
   Yang, Bing
   Tang, Dong-Xin
TI [Miao medicinal crossbow acupuncture therapy as adjuvant treatment for lung 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE Miao medicinal crossbow acupuncture therapy; adverse reactions of medication; lung cancer; oxycodone hydrochloride extended-release tablet; pain
AB OBJECTIVE: To observe the clinical efficacy of Miao medicinal crossbow 
   acupuncture therapy as adjuvant treatment for lung cancer pain based on oxycodone 
   hydrochloride extended-release tablet. METHODS: A total of 60 patients with lung 
   cancer pain were randomized into an observation group (30 cases, 1 case dropped 
   off) and a control group (30 cases). In the control group, oxycodone 
   hydrochloride extended-release tablet was given orally, 10 mg a time, once every 
   12 hours. On the basis of the treatment in the control group, Miao medicinal 
   crossbow acupuncture therapy was applied once every other day in the observation 
   group. The treatment of 14 days was required in the two groups. Before and after 
   treatment, the numerical rating scale (NRS) score, number of break-out pain and 
   Karnofsky performance status (KPS) score were observed in the two groups. The 
   equivalent oxycodone consumption and rate of adverse reactions were recorded, the 
   analgesic effect was evaluated in the two groups. RESULTS: Compared before 
   treatment, the NRS scores and number of break-out pain were decreased while the 
   KPS scores were increased after treatment in the two groups (P<0.01). After 
   treatment, the NRS score and number of break-out pain in the observation group 
   were lower than the control group (P<0.01), the KPS score in the observation 
   group was higher than the control group (P<0.05). The equivalent oxycodone 
   consumption of whole course and the rate of adverse reactions i.e. constipation, 
   drowsiness, nausea and vomiting in the observation group were lower than the 
   control group (P<0.05). The analgesic effect rate was 93.1% (27/29) in the 
   observation group, which was superior to 63.3% (19/30) in the control group 
   (P<0.05). CONCLUSION: On the basis of oxycodone hydrochloride extended-release 
   tablet, Miao medicinal crossbow acupuncture therapy as adjuvant treatment can 
   effectively relieve the pain degree, reduce the number of break-out pain and 
   improve the health status and quality of life in patients with lung cancer pain, 
   enhance the efficacy of medication and reduce its adverse reactions.
C1 First Clinical Medical College of Guizhou University of TCM, Guiyang 550002, China.
   Department of Oncology, First Affiliated Hospital of Guizhou University of TCM, Guiyang 550001.
   Department of Oncology, First Affiliated Hospital of Guizhou University of TCM, Guiyang 550001.
   First Clinical Medical College of Guizhou University of TCM, Guiyang 550002, China.
   First Clinical Medical College of Guizhou University of TCM, Guiyang 550002, China.
   Department of Oncology, First Affiliated Hospital of Guizhou University of TCM, Guiyang 550001.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAR 2
PY 2023
VL 43
IS 3
BP 322
EP 6
DI 10.13703/j.0255-2930.20220816-k0001 
PG -316
WC Humans; Cancer Pain; Oxycodone; Quality of Life; Lung Neoplasms; Pain; Acupuncture Therapy; Adjuvants, Immunologic; Lung; Analgesics
UT PubMed:36858396
PM 36858396
DA 2023-03-02
ER

PT J
AU Jiang, B
   Zhong, X
   Fang, J
   Zhang, A
   WangD, W
   Liang, Y
   Fang, J
   Chen, F
   Du, J
AF Jiang, Bin
   Zhong, Xuemei
   Fang, Junfan
   Zhang, Aijun
   WangD, Wen
   Liang, Yi
   Fang, Jianqiao
   Chen, Feng
   Du, Junying
TI Electroacupuncture Attenuates Morphine Tolerance in Rats with Bone Cancer Pain by 
SO Integrative cancer therapies
LA English
DT Journal Article
DE IGF-1; JNK1/2; LY294002; PI3K/Akt; bone cancer pain; electroacupuncture; morphine tolerance
AB PURPOSE: Morphine is often used for the treatment of moderate and severe cancer 
   pain, but long-term use can lead to morphine tolerance. Methods for effectively 
   inhibiting morphine tolerance and the related mechanism of action are of great 
   significance for the treatment of cancer pain. Previous studies have shown that 
   electroacupuncture (EA) can inhibit the occurrence of morphine tolerance, but the 
   mechanism is not yet clear. The aim of the present study was to explore the 
   signaling pathway by which EA attenuates the development of bone cancer pain 
   (BCP)-morphine tolerance (MT). MATERIALS AND METHODS: Changes in the paw 
   withdrawal threshold (PWT) of rats with bone cancer pain-morphine tolerance were 
   observed in a study of EA combined with intrathecal injection of a PI3K inhibitor 
   (LY294002) or agonist (insulin-like growth factor-1 [IGF-1]). We also tested the 
   protein expression of phosphorylated phosphatidylinositol 3-kinase (p-PI3K), 
   phosphorylated protein kinase B (p-Akt), phosphorylated c-Jun NH(2)-terminal 
   kinase 1/2 (p-JNK1/2), and β-arrestin2 in the L4-6 spinal dorsal horn of rats. 
   RESULTS: The protein expression of p-PI3K, p-Akt, p-JNK1/2, and β-arrestin2 was 
   upregulated in the L4-6 spinal dorsal horn of rats with bone cancer pain and bone 
   cancer pain-morphine tolerance. EA delayed the occurrence of morphine tolerance 
   in rats with bone cancer pain and downregulated the protein expression of p-PI3K, 
   p-Akt, p-JNK1/2, and β-arrestin2 in the L4-6 spinal dorsal horn of rats with bone 
   cancer pain-morphine tolerance. Intrathecal injection of LY294002 attenuated the 
   development of morphine tolerance and downregulated the protein expression of 
   p-Akt, p-JNK1/2, and β-arrestin2 in the spinal dorsal horn of rats with bone 
   cancer pain-morphine tolerance. In addition, the inhibitory effect of EA on 
   morphine tolerance was reversed by IGF-1. CONCLUSION: The mechanism underlying 
   the ability of EA to attenuate morphine tolerance may be associated with 
   inhibition of the PI3K/Akt/JNK1/2 signaling pathway.
C1 Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Jiaxing, Zhejiang, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical 
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture andNeurology of Zhejiang Province, Hangzhou, China.
   The Second Clinical College of Zhejiang University of Traditional Chinese 
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture andNeurology of Zhejiang Province, Hangzhou, China.
   Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Jiaxing, Zhejiang, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture andNeurology of Zhejiang Province, Hangzhou, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture andNeurology of Zhejiang Province, Hangzhou, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture andNeurology of Zhejiang Province, Hangzhou, China.
   Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Jiaxing, Zhejiang, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture andNeurology of Zhejiang Province, Hangzhou, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD MAR 5
PY 2021
VL 20
IS 
BP 1534735421995237
EP 1534735421995237
DI 10.1177/1534735421995237 
PG 1
WC Animals; Cancer Pain; drug therapy; Electroacupuncture; Morphine; pharmacology; Neoplasms; Phosphatidylinositol 3-Kinases; metabolism; Proto-Oncogene Proteins c-akt; metabolism; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord Dorsal Horn; metabolism
UT PubMed:33660537
PM 33660537
DA 2021-03-05
ER

PT J
AU Alræk, T
   Skjerve, H
   Sørensen, A
   Lie, SA
   Presterud, Ødegård H
   Lu, W
   Mao, J
   Deng, G
   Lee, MS
   Birch, S
   Lamu, AN
   Kim, TH
   MacPherson, H
AF Alræk, Terje
   Skjerve, Hilde
   Sørensen, Anette
   Lie, S A
   Presterud Ødegård, Hilde
   Lu, Weidong
   Mao, Jun
   Deng, G
   Lee, Myeong Soo
   Birch, Stephen
   Lamu, Admassu Nadew
   Kim, Tae-Hun
   MacPherson, Hugh
TI Acupuncture for fatigue in breast cancer survivors: a study protocol for a 
SO BMJ open
LA English
DT Journal Article
DE Acupuncture; COMPLEMENTARY MEDICINE; Clinical Trial; Fatigue; Randomized Controlled Trial
AB INTRODUCTION: Fatigue is a common symptom observed in post-cancer treatment, yet 
   its underlying mechanisms remain poorly understood. Acupuncture has been employed 
   to alleviate cancer-related fatigue (CRF); however, its effectiveness in 
   addressing associated comorbidities that may influence fatigue is also poorly 
   understood. This study represents the first investigation to use acupuncture as 
   an intervention for fatigue in breast cancer survivors within a Norwegian cohort. 
   The study will employ questionnaires to evaluate various facets of fatigue. As a 
   pragmatic trial, it statistically assesses its clinical relevance, documents 
   adverse events and evaluates the cost-effectiveness of the acupuncture treatment. 
   METHODS AND ANALYSIS: This assessor-blinded, pragmatic, randomised, mixed method, 
   controlled trial with two parallel arms aims to evaluate the effectiveness, 
   safety and cost-effectiveness of acupuncture. It will recruit 250 participants 
   presented with CRF for 6 months or longer. Patients will be randomly allocated 
   either to acupuncture and usual care (n=125) or to usual care alone (n=125). 
   Acupuncture treatments (12 in total) are to be given within 12 weeks. The 
   statistician who will analyse the data will be blinded to group allocation. The 
   primary outcome will be changes in CRF measured by the Chalder fatigue scale. 
   Measurements will be taken 12 weeks and 6 months after randomisation. The 
   secondary outcomes include patient-reported outcomes of pain, anxiety, 
   depression, hot flashes, insomnia and sleepiness. Health-related quality of life 
   and economic evaluation will also be conducted 12 weeks and 6 months after 
   randomisation. Nested within this randomised controlled trial are two qualitative 
   studies and one sub-study measuring biomarkers (C-reactive protein, interleukin 
   (IL)-1, IL-6, tumour necrosis factor alpha (TNF-α) and aPL in addition to the 
   current genotype genes TNF-308 and IL-6-174) from blood samples (n=80). Such 
   biomarkers can potentially address changes in CRF. ETHICS AND DISSEMINATION: 
   Ethical approval of this study has been granted by the Regional Committees for 
   Medical and Health Research Ethics (REC southeast ID number: 112285). Written 
   informed consent will be obtained from all participants. The outcomes of the 
   trial will be disseminated through peer-reviewed publications. TRIAL REGISTRATION 
   NUMBER: NCT04418115.
C1 Department of Community Medicine, The Artic University of Norway Department of Clinical Medicine, Tromso, Norway terje.alrak@uit.no.
   Department of Health and Excercise, Kristiania University College, Oslo, Norway.
   Department of Health and Excercise, Kristiania University College, Oslo, Norway.
   Department of Health and Excercise, Kristiania University College, Oslo, Norway.
   Department of Dentistry, University of Bergen Faculty of Medicine and Dentistry, Bergen, Norway.
   Diakonhjemmet University College and Hospital, Oslo, Norway.
   Department of Medical Oncology, Harvard Medical School, Boston, Massachusetts, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York, USA.
   Korea Institute of Oriental Medicine, Daejeon, Korea (the Republic of).
   Department of Health and Excercise, Kristiania University College, Oslo, Norway.
   NORCE Norwegian Research Centre AS, Bergen, Norway.
   Korean Medicine Clinical Trial Center, Kyung Hee University, Seoul, Korea (the Republic of).
   Health Sciences, University of York, York, UK.
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD JUL 31
PY 2024
VL 14
IS 7
BP e077514
EP e077514
DI 10.1136/bmjopen-2023-077514 
PG 1
WC Humans; Fatigue; therapy; Breast Neoplasms; complications; Female; Cancer Survivors; Acupuncture Therapy; methods; Quality of Life; Pragmatic Clinical Trials as Topic; Norway; Cost-Benefit Analysis
UT PubMed:39079925
PM 39079925
DA 2024-07-31
ER

PT J
AU Shin, S
   Jang, BH
   Park, SH
   Lee, JW
   Chae, MS
   Kim, N
   Suh, HS
   Han, S
   Min, SY
   Baek, SK
   Lim, YJ
   Hwang, DS
AF Shin, Seungwon
   Jang, Bo-Hyoung
   Park, Seung-Hyeok
   Lee, Jin-Wook
   Chae, Min Soo
   Kim, Namhoon
   Suh, Hae Sun
   Han, Sola
   Min, Sun Young
   Baek, Sun Kyung
   Lim, Yu Jin
   Hwang, Deok-Sang
TI Effectiveness, safety, and economic evaluation of adjuvant moxibustion therapy 
SO Medicine
LA English
DT Journal Article
AB INTRODUCTION: This study is a prospective, assessor-blinded, parallel-group, 
   randomized controlled pilot trial to explore the effectiveness of 12-week 
   adjuvant moxibustion therapy for arthralgia in menopausal females at stage I to 
   III breast cancer on aromatase inhibitor (AI) administration, compared with those 
   receiving usual care. METHODS/DESIGN: Forty-six menopausal female patients with 
   breast cancer who completed cancer therapy will be randomly allocated to either 
   adjuvant moxibustion or usual care groups with a 1:1 allocation ratio. The 
   intervention group will undergo 24 sessions of adjuvant moxibustion therapy with 
   usual care for 12 weeks, whereas the control group will receive only usual care 
   during the same period. The usual care consists of acetaminophen administration 
   on demand and self-directed exercise education to manage AI-related joint pain. 
   The primary outcome is the mean change of the worst pain level according to the 
   Brief Pain Inventory-Short Form between the initial visit and the endpoint. The 
   mean changes in depression, fatigue, and quality of life will also be compared 
   between groups. Safety and pharmacoeconomic evaluations will also be included. 
   DISCUSSION: Continuous variables will be compared by an independent t test or 
   Wilcoxon rank-sum test between the adjuvant moxibustion and usual care groups. 
   Adverse events will be analyzed using the chi-square or Fisher exact test. The 
   statistical analysis will be performed by a 2-tailed test at a significance level 
   of .05.
C1 Clinical Trial Center, Korean Medicine Hospital, Kyung Hee University.
   Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University.
   Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul.
   Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul.
   Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul.
   Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul.
   Pharmaceutical Economics, Outcomes Research and Policy, Pusan National University, Busan.
   College of Pharmacy, Pusan National University, Busan.
   Department of Surgery, College of Medicine, Kyung Hee University.
   Department of Internal Medicine, College of Medicine, Kyung Hee University.
   Department of Radiation Oncology, Kyung Hee University Medical Center, Kyung Hee University College of Medicine.
   Department of Korean Obstetrics & Gynecology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD OCT 1
PY 2019
VL 98
IS 38
BP e17260
EP e17260
DI 10.1097/MD.0000000000017260 
PG 1
WC Aged; Female; Humans; Middle Aged; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Cost-Benefit Analysis; Health Care Costs; Moxibustion; adverse effects; Pilot Projects; Postmenopause; Treatment Outcome; Randomized Controlled Trials as Topic
UT PubMed:31568000
PM 31568000
DA 2019-10-01
ER

PT J
AU Li, Y
   Wu, F
   Wei, J
   Lao, L
   Shen, X
AF Li, Yuan
   Wu, Fan
   Wei, Jianzi
   Lao, Lixing
   Shen, Xueyong
TI Laser Moxibustion Alleviates Knee Osteoarthritis Pain by Inhibiting Spinal 
SO Photobiomodulation, photomedicine, and laser surgery
LA English
DT Journal Article
DE glial activation; knee osteoarthritis pain; laser moxibustion; neuroinflammation
AB Background: Central sensitization driven by glial activation-mediated 
   neuroinflammation is recognized as a key mechanism in pain processing. Laser 
   moxibustion using low-intensity laser irradiation of corresponding acupoints 
   significantly relieves knee osteoarthritis (KOA) pain. However, the underlying 
   mechanism of its effects on KOA pain is still not completely understood. 
   Objective: In this study, we aimed to investigate whether laser moxibustion could 
   alleviate KOA pain by inhibiting spinal glial activation and proinflammatory 
   cytokines upregulation in monosodium iodoacetate (MIA)-induced KOA pain in rats. 
   Materials and methods: Sprague-Dawley rats were divided randomly into three 
   groups: Saline + Sham Laser, MIA + Laser, and MIA + Sham Laser. A 10.6 μm laser 
   was used to irradiate ST35 (Dubi) for 10 min once every 2 days for a total of 
   seven applications. The paw withdrawal mechanical threshold and weight-bearing 
   distribution were performed to evaluate the nociceptive behaviors. Spinal 
   expressions of microglial marker, ionized calcium binding adaptor molecule-1 
   (Iba-1); astrocyte marker, glial fibrillary acidic protein (GFAP); 
   pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin-1β 
   (IL-1β), and interleukin-6 (IL-6) were measured 14 days after MIA injection. 
   Results: The results showed that laser moxibustion significantly reversed the 
   MIA-induced mechanical hyperalgesia and weight-bearing difference up to 14 days 
   compared with MIA + Sham Laser group (p < 0.05 or p < 0.01). Moreover, both the 
   protein level and immunofluorescence intensity of Iba-1 in the ipsilateral spinal 
   cord dorsal horn were markedly decreased in the MIA + Laser group than those in 
   the MIA + Sham Laser group (p < 0.01). However, there was no significant 
   difference in the expression of GFAP between groups (p > 0.05). In addition, 
   laser moxibustion decreased the upregulation of TNF-α, IL-1β, and IL-6 compared 
   with the MIA + Sham Laser group (p < 0.01). Conclusions: This study demonstrated 
   that laser moxibustion at ST35 significantly alleviated MIA-induced KOA pain 
   through inhibition of the microglial activation-mediated neuroinflammation, at 
   least partially, by suppressing the production of proinflammatory cytokines, 
   which may provide a potential analgesic target for KOA pain relief.
C1 School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   School of Chinese Medicine, The University of Hong Kong, Hong Kong SAR, China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Shanghai Research Center of Acupuncture & Meridian, Shanghai, China.
NR 0
TC 0
SN 2578-547
EI 
J9 Photobiomodul Photomed Laser Surg
PD JAN 25
PY 2020
VL 38
IS 4
BP 237
EP 243
DI 10.1089/photob.2019.4744 
PG 6
WC Animals; Cytokines; metabolism; Disease Models, Animal; Iodoacetic Acid; Low-Level Light Therapy; Male; Microglia; physiology; Moxibustion; Osteoarthritis, Knee; complications; Pain; etiology; Rats; Rats, Sprague-Dawley
UT PubMed:31976816
PM 31976816
DA 2020-01-25
ER

PT J
AU Lei, Y
   Duan, Y
   Wang, J
   Yu, X
   Deng, S
   Liu, R
   Si, H
   Li, J
   Zhang, B
AF Lei, Yi
   Duan, Yunyun
   Wang, Jisheng
   Yu, Xudong
   Deng, Sheng
   Liu, Ruijia
   Si, Hongmei
   Li, Jiameng
   Zhang, Bao
TI A randomized controlled trial for acupuncture combined with conventional therapy 
SO Medicine
LA English
DT Journal Article
AB INTRODUCTION: Prostate cancer refers to an epithelial malignant tumor that occurs 
   in the prostate area. In recent years, with the improvement of people's living 
   standards, the incidence of prostate cancer has gradually increased, which has 
   greatly affected people's life and health and quality of life. Acupuncture has 
   its unique advantages in treating cancer pain. We will evaluate the efficacy and 
   safety of acupuncture and moxibustion in the treatment of pain caused by prostate 
   cancer using a clinical randomized parallel control method. METHODS/DESIGN: This 
   pragmatic randomized controlled trial will recruit 120 patients who are diagnosed 
   with prostate cancer. Simple randomization to conventional drug treatment with a 
   1:1 allocation ratio will be used. Based on the patient's pain location and the 
   primary lesion, the acupuncture needle insertion position was determined 
   according to the principle of local selection of acupoints. All participants will 
   continue to receive conventional drug treatment. DISCUSSION: This trial may 
   provide evidence regarding the clinical effectiveness, safety, and 
   cost-effectiveness of acupuncture for pain caused by prostate cancer. TRIAL 
   REGISTRATION: ClinicalTrials.gov, ChiCTR2000029801, Registered on 14 February 
   2020.
C1 The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi.
   The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi.
   Graduate School of Beijing University of Chinese Medicine.
   Department of Andrology.
   Graduate School of Beijing University of Chinese Medicine.
   Department of Andrology.
   Graduate School of Beijing University of Chinese Medicine.
   Department of Andrology.
   Graduate School of Beijing University of Chinese Medicine.
   The Fist Department of Neurology, Dongzhimen Hospital, Beijing University of 
   Graduate School of Beijing University of Chinese Medicine.
   Department of Andrology.
   Graduate School of Beijing University of Chinese Medicine.
   Department of Andrology.
   The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD APR 4
PY 2020
VL 99
IS 14
BP e19609
EP e19609
DI 10.1097/MD.0000000000019609 
PG 1
WC Acupuncture Therapy; methods; Aged; Cancer Pain; etiology; Cost-Benefit Analysis; Humans; Male; Middle Aged; Moxibustion; methods; Pain Management; methods; Pain Measurement; Prostatic Neoplasms; complications; Randomized Controlled Trials as Topic; Treatment Outcome; Pragmatic Clinical Trials as Topic
UT PubMed:32243384
PM 32243384
DA 2020-04-04
ER

PT J
AU Liou, KT
   Trevino, KM
   Meghani, SH
   Li, QS
   Deng, G
   Korenstein, D
   Mao, JJ
AF Liou, Kevin T
   Trevino, Kelly M
   Meghani, Salimah H
   Li, Q Susan
   Deng, Gary
   Korenstein, Deborah
   Mao, Jun J
TI Fear of analgesic side effects predicts preference for acupuncture: a 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture; Analgesics; Barriers; Cancer; Opioids; Pain management; Preference
AB PURPOSE: Approximately one in two cancer patients globally are under-treated for 
   pain. Opioids and other analgesics represent the mainstay of cancer pain 
   management; however, barriers to their use are well-documented. We evaluated 
   whether acupuncture would be a preferable treatment option among cancer patients 
   with attitudinal barriers to pharmacological pain management. METHODS: We 
   conducted a cross-sectional survey of cancer patients at a tertiary urban cancer 
   center and eleven suburban/rural hospitals in the Northeastern United States. We 
   assessed attitudinal barriers to pharmacological pain management with the 
   Barriers Questionnaire (BQ-13). The BQ-13 consists of two subscales: pain 
   management beliefs and analgesic side effects. We also asked patients whether 
   they prefer acupuncture, analgesics, or have no preference between these two 
   modalities for pain management. Covariates included sociodemographics, clinical 
   characteristics, and attitudes/beliefs about acupuncture. We used logistic 
   regression to examine the association between attitudinal barriers and 
   acupuncture preference. RESULTS: Among 628 patients, 197 (31.4%) preferred 
   acupuncture for pain management, 146 (23.3%) preferred analgesics, and 285 
   (45.4%) had no preference. The highest reported attitudinal barriers were fear of 
   addiction and fear of analgesic-associated constipation and nausea. Adjusting for 
   covariates, we found that attitudinal barriers related to fear of analgesic side 
   effects were significantly associated with acupuncture preference (adjusted odds 
   ratio [AOR] 1.45, 95% confidence interval [CI] 1.17-1.81), but barriers related 
   to pain management beliefs were not (AOR 1.17, 95% CI 0.91-1.51). 
   Attitudes/beliefs about acupuncture (i.e., greater expected benefits, fewer 
   perceived barriers, and more positive social norms) and female gender also 
   predicted acupuncture preference, whereas race and educational status did not. 
   CONCLUSION: Acupuncture may be a preferable treatment option among cancer 
   patients at risk of inadequately controlled pain due to fear of analgesic side 
   effects. Evidence-based integration of acupuncture and analgesics, guided by 
   patient treatment preferences, represents an essential aspect of patient-centered 
   care and has potential to address unmet cancer pain management needs.
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA. liouk@mskcc.org.
   Department of Medicine, Weill Cornell Medicine, New York, NY, USA. 
   Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
   Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
   Department of Medicine and Center for Health Policy and Outcomes, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
   Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
NR 0
TC 0
SN 1433-733
EI 0941-435
J9 Support Care Cancer
PD MAY 10
PY 2020
VL 29
IS 1
BP 427
EP 435
DI 10.1007/s00520-020-05504-y 
PG 8
WC Acupuncture Therapy; methods; Analgesics; therapeutic use; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Neoplasms; complications; Pain; drug therapy; Pain Management; methods; United States
UT PubMed:32383073
PM 32383073
DA 2020-05-10
ER

PT J
AU Yang, J
   Xiong, X
   Wei, Q
   Yang, L
AF Yang, Jie
   Xiong, Xingyu
   Wei, Qiang
   Yang, Lu
TI Acupuncture: a promising adjuvant strategy for pain management among the patients 
SO BJU international
LA English
DT Letter
C1 Department of Urology, Institute of Urology, Center of Biomedical Big Data and National Clinical Research Center for Geriatrics, West China Hospital of SichuanUniversity, Chengdu, Sichuan Province, China.
   Department of Urology, Institute of Urology, Center of Biomedical Big Data and National Clinical Research Center for Geriatrics, West China Hospital of SichuanUniversity, Chengdu, Sichuan Province, China.
   Department of Urology, Institute of Urology, Center of Biomedical Big Data and National Clinical Research Center for Geriatrics, West China Hospital of SichuanUniversity, Chengdu, Sichuan Province, China.
   Department of Urology, Institute of Urology, Center of Biomedical Big Data and National Clinical Research Center for Geriatrics, West China Hospital of SichuanUniversity, Chengdu, Sichuan Province, China.
NR 0
TC 0
SN 1464-410
EI 
J9 BJU Int
PD JUL 18
PY 2024
VL 134
IS 4
BP 664
EP 665
DI 10.1111/bju.16467 
PG 1
WC Humans; Male; Prostatic Neoplasms; therapy; Pain Management; methods; Acupuncture Therapy; Cancer Pain; therapy
UT PubMed:39019800
PM 39019800
DA 2024-07-18
ER

PT J
AU Li, H
   Schlaeger, JM
   Jang, MK
   Lin, Y
   Park, C
   Liu, T
   Sun, M
   Doorenbos, AZ
AF Li, Hongjin
   Schlaeger, Judith M
   Jang, Min Kyeong
   Lin, Yufen
   Park, Chang
   Liu, Tingting
   Sun, Min
   Doorenbos, Ardith Z
TI Acupuncture Improves Multiple Treatment-Related Symptoms in Breast Cancer 
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
DE acupuncture; breast cancer; meta-analysis; symptom; symptom cluster
AB Introduction: Acupuncture has demonstrated effectiveness for symptom management 
   among breast cancer survivors. This meta-analysis aims to evaluate the effect of 
   acupuncture on treatment-related symptoms among breast cancer survivors. Methods: 
   The authors searched PubMed, CINAHL, and EMBASE for relevant randomized clinical 
   trials (RCTs) of acupuncture for managing treatment-related symptoms published in 
   English through June 2021. They appraised the quality of each article using the 
   Cochrane Collaboration Risk of Bias Criteria. The primary outcomes were pain, hot 
   flashes, sleep disturbance, fatigue, depression, lymphedema, and neuropathy as 
   individual symptoms. They also evaluated adverse events reported in acupuncture 
   studies. Results: Of 26 selected trials (2055 patients), 20 (1709 patients) were 
   included in the meta-analysis. Acupuncture was more effective than control groups 
   in improving pain intensity [standardized mean difference (SMD) = -0.60, 95% 
   confidence intervals (CI) -1.06 to -0.15], fatigue [SMD = -0.62, 95% CI -1.03 to 
   -0.20], and hot flash severity [SMD = -0.52, 95% CI -0.82 to -0.22]. The subgroup 
   analysis indicated that acupuncture showed trends but not significant effects on 
   all the treatment-related symptoms compared with the sham acupuncture groups. 
   Compared with waitlist control and usual care groups, the acupuncture groups 
   showed significant reductions in pain intensity, fatigue, depression, hot flash 
   severity, and neuropathy. No serious adverse events were reported related to 
   acupuncture intervention. Mild adverse events (i.e., bruising, pain, swelling, 
   skin infection, hematoma, headache, menstrual bleeding) were reported in 11 
   studies. Conclusion: This systematic review and meta-analysis suggest that 
   acupuncture significantly reduces multiple treatment-related symptoms compared 
   with the usual care or waitlist control group among breast cancer survivors. The 
   safety of acupuncture was inadequately reported in the included studies. Based on 
   the available data, acupuncture seems to be generally a safe treatment with some 
   mild adverse events. These findings provide evidence-based recommendations for 
   incorporating acupuncture into clinical breast cancer symptom management. Due to 
   the high risk of bias and blinding issues in some RCTs, more rigorous trials are 
   needed to confirm the efficacy of acupuncture in reducing multiple 
   treatment-related symptoms among breast cancer survivors.
C1 Department of Human Development Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, IL, USA.
   Department of Cancer Prevention and Control, University of Illinois Cancer 
   Department of Human Development Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, IL, USA.
   Department of Cancer Prevention and Control, University of Illinois Cancer Center, Chicago, IL, USA.
   Department of Biobehavioral Nursing Science, College of Nursing, University of 
   School of Nursing, Emory University, Atlanta, GA, USA.
   Department of Population Health Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, IL, USA.
   Eleanor Mann School of Nursing, University of Arkansas, Little Rock, AR, USA.
   Department of Hematology and Oncology, Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
   Department of Cancer Prevention and Control, University of Illinois Cancer Center, Chicago, IL, USA.
   Department of Biobehavioral Nursing Science, College of Nursing, University of 
NR 0
TC 0
SN 1557-770
EI 1075-553
J9 J Altern Complement Med
PD AUG 28
PY 2021
VL 27
IS 12
BP 1084
EP 1097
DI 10.1089/acm.2021.0133 
PG 13
WC Acupuncture Therapy; Breast Neoplasms; complications; Cancer Survivors; Fatigue; etiology; Female; Humans; Survivors
UT PubMed:34449251
PM 34449251
DA 2021-08-28
ER

PT J
AU Bauml, J
   Xie, SX
   Farrar, JT
   Bowman, MA
   Li, SQ
   Bruner, D
   DeMichele, A
   Mao, JJ
AF Bauml, Joshua
   Xie, Sharon X
   Farrar, John T
   Bowman, Marjorie A
   Li, Susan Q
   Bruner, Deborah
   DeMichele, Angela
   Mao, Jun J
TI Expectancy in real and sham electroacupuncture: does believing make it so?
SO Journal of the National Cancer Institute. Monographs
LA English
DT Journal Article
AB BACKGROUND: The large placebo effect observed in prior acupuncture trials 
   presents a substantial challenge for interpretation of the efficacy of 
   acupuncture. We sought to evaluate the relationship between response expectancy, 
   a key component of the placebo effect over time, and treatment outcome in real 
   and sham electroacupuncture (EA). METHODS: We analyzed data from a randomized 
   controlled trial of EA and sham acupuncture (SA) for joint pain attributable to 
   aromatase inhibitors among women with breast cancer. Responders were identified 
   using the Patient Global Impression of Change instrument at Week 8 (end of 
   intervention). The Acupuncture Expectancy Scale (AES) was used to measure 
   expectancy four times during the trial. Linear mixed-effects models were used to 
   evaluate the association between expectancy and treatment response. RESULTS: In 
   the wait list control group, AES remained unchanged over treatment. In the SA 
   group, Baseline AES was significantly higher in responders than nonresponders 
   (15.5 vs 12.1, P = .005) and AES did not change over time. In the EA group, 
   Baseline AES scores did not differ between responders and nonresponders (14.8 vs 
   15.3, P = .64); however, AES increased in responders compared with nonresponders 
   over time (P = .004 for responder and time interaction term) with significant 
   difference at the end of trial for responders versus nonresponders (16.2 vs 11.7, 
   P = .004). CONCLUSIONS: Baseline higher response expectancy predicts treatment 
   response in SA, but not in EA. Divergent mechanisms may exist for how SA and EA 
   influence pain outcomes, and patients with low expectancy may do better with EA 
   than SA.
C1 Division of Hematology/Oncology (JB, AD), Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM), Department of Anesthesia and Critical Care(JTF), Department of Family Medicine and Community Health (SQL, JJM), PerelmanSchool of Medicine at the University of Pennsylvania, Philadelphia, PA (JB, AD);Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (JB, AD,JJM)
   Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM) andDepartment of Anesthesia and Critical Care (JTF), Perelman School of Medicine atthe University of Pennsylvania, Philadelphia, PA
   Boonshoft School of Medicine,Wright State University, Dayton, OH (MAB)
   Nell Hodgson School of Nursing, EmoryUniversity, Atlanta, GA (DB).
   Division of Hematology/Oncology (JB, AD), Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM), Department of Anesthesia and Critical Care(JTF), Department of Family Medicine and Community Health (SQL, JJM), PerelmanSchool of Medicine at the University of Pennsylvania, Philadelphia, PA (JB, AD);Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (JB, AD,JJM)
   Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM) andDepartment of Anesthesia and Critical Care (JTF), Perelman School of Medicine atthe University of Pennsylvania, Philadelphia, PA
   Boonshoft School of Medicine,Wright State University, Dayton, OH (MAB)
   Nell Hodgson School of Nursing, EmoryUniversity, Atlanta, GA (DB).
   Division of Hematology/Oncology (JB, AD), Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM), Department of Anesthesia and Critical Care(JTF), Department of Family Medicine and Community Health (SQL, JJM), PerelmanSchool of Medicine at the University of Pennsylvania, Philadelphia, PA (JB, AD);Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (JB, AD,JJM)
   Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM) andDepartment of Anesthesia and Critical Care (JTF), Perelman School of Medicine atthe University of Pennsylvania, Philadelphia, PA
   Boonshoft School of Medicine,Wright State University, Dayton, OH (MAB)
   Nell Hodgson School of Nursing, EmoryUniversity, Atlanta, GA (DB).
   Division of Hematology/Oncology (JB, AD), Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM), Department of Anesthesia and Critical Care(JTF), Department of Family Medicine and Community Health (SQL, JJM), PerelmanSchool of Medicine at the University of Pennsylvania, Philadelphia, PA (JB, AD);Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (JB, AD,JJM)
   Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM) andDepartment of Anesthesia and Critical Care (JTF), Perelman School of Medicine atthe University of Pennsylvania, Philadelphia, PA
   Boonshoft School of Medicine,Wright State University, Dayton, OH (MAB)
   Nell Hodgson School of Nursing, EmoryUniversity, Atlanta, GA (DB).
   Division of Hematology/Oncology (JB, AD), Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM), Department of Anesthesia and Critical Care(JTF), Department of Family Medicine and Community Health (SQL, JJM), PerelmanSchool of Medicine at the University of Pennsylvania, Philadelphia, PA (JB, AD);Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (JB, AD,JJM)
   Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM) andDepartment of Anesthesia and Critical Care (JTF), Perelman School of Medicine atthe University of Pennsylvania, Philadelphia, PA
   Boonshoft School of Medicine,Wright State University, Dayton, OH (MAB)
   Nell Hodgson School of Nursing, EmoryUniversity, Atlanta, GA (DB).
   Division of Hematology/Oncology (JB, AD), Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM), Department of Anesthesia and Critical Care(JTF), Department of Family Medicine and Community Health (SQL, JJM), PerelmanSchool of Medicine at the University of Pennsylvania, Philadelphia, PA (JB, AD);Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (JB, AD,JJM)
   Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM) andDepartment of Anesthesia and Critical Care (JTF), Perelman School of Medicine atthe University of Pennsylvania, Philadelphia, PA
   Boonshoft School of Medicine,Wright State University, Dayton, OH (MAB)
   Nell Hodgson School of Nursing, EmoryUniversity, Atlanta, GA (DB).
   Division of Hematology/Oncology (JB, AD), Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM), Department of Anesthesia and Critical Care(JTF), Department of Family Medicine and Community Health (SQL, JJM), PerelmanSchool of Medicine at the University of Pennsylvania, Philadelphia, PA (JB, AD);Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (JB, AD,JJM)
   Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM) andDepartment of Anesthesia and Critical Care (JTF), Perelman School of Medicine atthe University of Pennsylvania, Philadelphia, PA
   Boonshoft School of Medicine,Wright State University, Dayton, OH (MAB)
   Nell Hodgson School of Nursing, EmoryUniversity, Atlanta, GA (DB).
   Division of Hematology/Oncology (JB, AD), Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM), Department of Anesthesia and Critical Care(JTF), Department of Family Medicine and Community Health (SQL, JJM), PerelmanSchool of Medicine at the University of Pennsylvania, Philadelphia, PA (JB, AD);Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (JB, AD,JJM)
   Center for Clinical Epidemiology and Biostatistics (SXX, JTF, AD, JJM) andDepartment of Anesthesia and Critical Care (JTF), Perelman School of Medicine atthe University of Pennsylvania, Philadelphia, PA
   Boonshoft School of Medicine,Wright State University, Dayton, OH (MAB)
   Nell Hodgson School of Nursing, EmoryUniversity, Atlanta, GA (DB). jun.mao@uphs.upenn.edu.
NR 0
TC 0
SN 1745-661
EI 1052-677
J9 J Natl Cancer Inst Monogr
PD MAR 10
PY 2015
VL 2014
IS 50
BP 302
EP 7
DI 10.1093/jncimonographs/lgu029 
PG -295
WC Adult; Aged; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Electroacupuncture; psychology; Emotions; Female; Humans; Middle Aged; Placebo Effect; Placebos; Treatment Outcome
UT PubMed:25749596
PM 25749596
DA 2015-03-10
ER

PT J
AU Chokshi, SK
   Ladas, EJ
   Taromina, K
   McDaniel, D
   Rooney, D
   Jin, Z
   Hsu, WC
   Kelly, KM
AF Chokshi, Sagar K
   Ladas, Elena J
   Taromina, Katherine
   McDaniel, Douglas
   Rooney, Diane
   Jin, Zhezhen
   Hsu, Wei-Chun
   Kelly, Kara M
TI Predictors of acupuncture use among children and adolescents with cancer.
SO Pediatric blood & cancer
LA English
DT Journal Article
DE acupuncture therapy; integrative medicine; pediatric oncology; supportive care
AB BACKGROUND: Evidence for the application of acupuncture in pediatric oncology is 
   limited. We investigated the acceptance of acupuncture and factors associated 
   with its use among children and adolescents with cancer. METHODS: Ninety 
   acupuncture-naïve children receiving cancer treatment at Columbia University 
   Medical Center (CUMC) provided consent/assent for participation. Participants 
   could choose to receive or refuse integrative services offered at CUMC. Symptoms 
   were collected for a 6-month period with the Memorial Symptom Assessment Scale 
   (MSAS). Acute and delayed adverse events among participants who received 
   acupuncture were recorded. RESULTS: Fifty-four percent of the participants 
   elected to receive acupuncture. In total, 252 acupuncture sessions were 
   administered with a median of four sessions per patient (range 1-13 sessions). 
   Pain (56%), nausea (51%), lack of energy (50%), and irritability (43%) were the 
   most frequently reported symptoms in the whole cohort. Determinants of 
   acupuncture use included older age and ethnicity. Acupuncture was more likely 
   than other integrative modalities to be used for gastrointestinal and 
   constitutional symptoms including drowsiness (odds ratio [OR], 3.34; 95% 
   confidence interval [CI], 1.98-5.66; P < 0.0001), lack of energy (OR, 3.23; 95% 
   CI, 1.78-5.87; P = 0.0001), and pain (OR, 2.63; 95% CI, 1.46-4.72; P = 0.001). 
   Adverse events were reported by 3% of the participants. There was no increased 
   incidence of adverse events in children with thrombocytopenia (P = 0.189) or 
   neutropenia (P = 0.497). CONCLUSION: Our results highlight the potential use of 
   acupuncture as a safe, adjunctive therapy for symptom management within existing 
   supportive care regimens in pediatric oncology and potential areas to focus 
   research initiatives.
C1 Department of Obstetrics and Gynecology, Cooper University Hospital, Camden, New Jersey.
   Division of Pediatric Hematology, Oncology, and Stem Cell Transplant, Columbia University Medical Center, New York, New York.
   Institute of Human Nutrition, Columbia University Medical Center, New York, New 
   Division of Pediatric Hematology, Oncology, and Stem Cell Transplant, Columbia University Medical Center, New York, New York.
   Division of Pediatric Hematology, Oncology, and Stem Cell Transplant, Columbia University Medical Center, New York, New York.
   Division of Pediatric Hematology, Oncology, and Stem Cell Transplant, Columbia University Medical Center, New York, New York.
   Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York.
   Department of Healthcare Policy and Research, Weill Cornell Medical College, Cornell University, New York, New York.
   Division of Pediatric Hematology, Oncology, and Stem Cell Transplant, Columbia University Medical Center, New York, New York.
NR 0
TC 0
SN 1545-501
EI 
J9 Pediatr Blood Cancer
PD FEB 9
PY 2017
VL 64
IS 7
BP 
EP 
DI 10.1002/pbc.26424 
PG 0
WC Acupuncture Therapy; psychology; Adolescent; Child; Child, Preschool; Female; Humans; Infant; Male; Neoplasms; therapy; Patient Acceptance of Health Care; psychology; Prospective Studies; Young Adult
UT PubMed:28176457
PM 28176457
DA 2017-02-09
ER

PT J
AU Liu, X
   Li, S
   Wang, B
   An, L
   Ren, X
   Wu, H
AF Liu, Xing
   Li, Shuqin
   Wang, Baoguo
   An, Lixin
   Ren, Xiujun
   Wu, Haifeng
TI Intraoperative and postoperative anaesthetic and analgesic effect of multipoint 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE COMPLEMENTARY MEDICINE
AB OBJECTIVES: To investigate the anaesthetic and analgesic effect of multipoint 
   transcutaneous electrical acupuncture stimulation (TEAS) during supratentorial 
   tumour resection for postoperative recovery and side effects. METHODS: In a 
   blinded clinical trial, 92 patients scheduled for supratentorial craniotomy under 
   general anaesthesia were randomly allocated into either a multipoint TEAS (n=46) 
   or a sham TEAS group (n=46). All patients received total intravenous anaesthesia 
   (TIVA) with propofol and sufentanil. The target concentration of sufentanil was 
   adjusted and recorded according to mean arterial pressure (MAP), heart rate (HR) 
   and bispectral index (BIS). Patients in the TEAS group received TEAS 30 min 
   before anaesthesia induction and this was maintained throughout the operation at 
   four pairs of acupuncture points. Postoperative pain, recovery and side effects 
   were evaluated. RESULTS: Eighty-eight patients completed the study. Continuous 
   monitoring of MAP, HR and BIS showed stable values with no significant 
   differences between the two groups (p>0.05). Sufentanil target plasma 
   concentration in TEAS patients was significantly lower at some time points during 
   supratentorial craniotomy, and total sufentanil consumption was significantly 
   higher in the sham group (p<0.05). Postoperative recovery and pain were 
   significantly improved by TEAS (p<0.001), without the postoperative side effects. 
   CONCLUSIONS: Multipoint TEAS at both proximal and distal points combined with 
   TIVA can significantly decrease intraoperative sufentanil requirements, increase 
   pain relief on postoperative day 1 and improve postoperative recovery of patients 
   during supratentorial tumour resection, with no significant increase of side 
   effects. These findings suggest that multipoint TEAS may be clinically effective 
   as an adjunct to analgesia in intraoperative anaesthesia and postoperative pain 
   treatment and may speed recovery. TRIAL REGISTRATION NUMBER: Chinese Clinical 
   Trial Registry (registration number ChiCTR-TRC-10001078).
C1 Department of Anesthesiology, Beijing, Tian Tan Hospital, Capital Medical University, Beijing, China.
   Department of Anesthesiology, Beijing, Tian Tan Hospital, Capital Medical University, Beijing, China.
   Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
   Department of Anesthesiology, Beijing, Tian Tan Hospital, Capital Medical University, Beijing, China.
   School of Acupuncture-moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
   Teaching Affairs Department, China Rehabilitation Research Center, Beijing, China.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD MAY 1
PY 2015
VL 33
IS 4
BP 270
EP 6
DI 10.1136/acupmed-2014-010749 
PG -264
WC Acupuncture Analgesia; Acupuncture Points; Adult; Anesthesia, General; Anesthetics; administration & dosage; Combined Modality Therapy; Craniotomy; Female; Humans; Intraoperative Care; Male; Middle Aged; Pain, Postoperative; drug therapy; Sufentanil; administration & dosage; Supratentorial Neoplasms; surgery; Transcutaneous Electric Nerve Stimulation
UT PubMed:25926298
PM 25926298
DA 2015-05-01
ER

PT J
AU Yao, JL
   Yang, WX
   Wang, YC
   Jiao, LJ
   Shi, J
   Gong, YB
AF Yao, Jia-Lin
   Yang, Wen-Xiao
   Wang, Yi-Chao
   Jiao, Li-Jing
   Shi, Jun
   Gong, Ya-Bin
TI [Blade acupuncture combined with functional exercise for chronic pain after 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE blade acupuncture; functional exercise; non-small cell lung cancer; postoperative chronic pain; randomized controlled trial (RCT)
AB OBJECTIVE: To observe the clinical efficacy of blade acupuncture combined with 
   functional exercise for chronic pain after non-small cell lung cancer surgery. 
   METHODS: A total of 62 patients with chronic pain after surgery for non-small 
   cell lung cancer were randomly divided into an observation group and a control 
   group, 31 cases in each group. The patients in the control group were treated 
   with functional exercise. On the base of the treatment in the control group, the 
   patients in the observation group were treated with blade acupuncture at the 
   tendon nodes or painful points, once a week for 4 weeks. The visual analogue 
   scale (VAS) scores of pain before treatment and day 1, day 7, day 14, day 28 of 
   treatment and day 90, day 180 when follow up were compared between the two 
   groups; the brief pain inventory (BPI) scores before and after treatment were 
   compared between the two groups. RESULTS: The VAS score in the observation group 
   at each time point after treatment was lower than that before treatment (P<0.01), 
   and lower than that in the control group (P<0.01). Compared before treatment, the 
   daily life score, emotion score, walking ability score, sleep score and life 
   enjoyment score and total score of BPI in the observation group were reduced 
   after treatment (P<0.05), and the daily life score, emotion score, sleep score 
   and total score of BPI in the observation group were lower than those in the 
   control group (P<0.05). CONCLUSION: The blade acupuncture combined with 
   functional exercise could effectively alleviate the chronic pain after non-small 
   cell lung cancer surgery, improve the quality of life of patients, and the effect 
   is lasting and stable.
C1 Department of Oncology, Yueyang Hospital of Integrative Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China.
   Department of Oncology, Yueyang Hospital of Integrative Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China.
   Department of Oncology, Yueyang Hospital of Integrative Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China.
   Department of Oncology, Yueyang Hospital of Integrative Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China.
   Department of Oncology, Yueyang Hospital of Integrative Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China.
   Department of Oncology, Yueyang Hospital of Integrative Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAY 18
PY 2023
VL 42
IS 10
BP 1125
EP 8
DI 10.13703/j.0255-2930.20211203-k0001 
PG -1117
WC Humans; Carcinoma, Non-Small-Cell Lung; complications; Chronic Pain; etiology; Quality of Life; Acupuncture Points; Lung Neoplasms; complications; Acupuncture Therapy; Treatment Outcome
UT PubMed:37199203
PM 37199203
DA 2023-05-18
ER

PT J
AU Lau, CHY
   Wu, X
   Chung, VCH
   Liu, X
   Hui, EP
   Cramer, H
   Lauche, R
   Wong, SYS
   Lau, AYL
   Sit, RWS
   Ziea, ETC
   Ng, BFL
   Wu, JCY
AF Lau, Charlotte H Y
   Wu, Xinyin
   Chung, Vincent C H
   Liu, Xin
   Hui, Edwin P
   Cramer, Holger
   Lauche, Romy
   Wong, Samuel Y S
   Lau, Alexander Y L
   Sit, Regina W S
   Ziea, Eric T C
   Ng, Bacon F L
   Wu, Justin C Y
TI Acupuncture and Related Therapies for Symptom Management in Palliative Cancer 
SO Medicine
LA English
DT Journal Article
AB Available systematic reviews showed uncertainty on the effectiveness of using 
   acupuncture and related therapies for palliative cancer care. The aim of this 
   systematic review and meta-analysis was to summarize current best evidence on 
   acupuncture and related therapies for palliative cancer care. Five international 
   and 3 Chinese databases were searched. Randomized controlled trials (RCTs) 
   comparing acupuncture and related therapies with conventional or sham treatments 
   were considered. Primary outcomes included fatigue, paresthesia and dysesthesias, 
   chronic pain, anorexia, insomnia, limb edema, constipation, and health-related 
   quality of life, of which effective conventional interventions are limited. 
   Thirteen RCTs were included. Compared with conventional interventions, 
   meta-analysis demonstrated that acupuncture and related therapies significantly 
   reduced pain (2 studies, n = 175, pooled weighted mean difference: -0.76, 95% 
   confidence interval: -0.14 to -0.39) among patients with liver or gastric cancer. 
   Combined use of acupuncture and related therapies and Chinese herbal medicine 
   improved quality of life in patients with gastrointestinal cancer (2 studies, 
   n = 111, pooled standard mean difference: 0.75, 95% confidence interval: 
   0.36-1.13). Acupressure showed significant efficacy in reducing fatigue in lung 
   cancer patients when compared with sham acupressure. Adverse events for 
   acupuncture and related therapies were infrequent and mild. Acupuncture and 
   related therapies are effective in reducing pain, fatigue, and in improving 
   quality of life when compared with conventional intervention alone among cancer 
   patients. Limitations on current evidence body imply that they should be used as 
   a complement, rather than an alternative, to conventional care. Effectiveness of 
   acupuncture and related therapies for managing anorexia, reducing constipation, 
   paresthesia and dysesthesia, insomnia, and limb edema in cancer patients is 
   uncertain, warranting future RCTs in these areas.
C1 From the Faculty of Medicine (CHL)
   Hong Kong Institute of Integrative Medicine (XW, VCC, EPH, SYW, AYL, RWSS, JCW)
   Jockey Club School of Public Health andPrimary Care (XW, VCC, XL, SYW, RWSS)
   Comprehensive Cancer Trials Unit (EPH),The Chinese University of Hong Kong, Hong Kong, China
   Department of Internal andIntegrative Medicine (HC), Faculty of Medicine, Kliniken Essen-MitteUniversity ofDuisburg-Essen, Essen, Germany
   Australian Research Centre in Complementary andIntegrative Medicine (ARCCIM) (HC), Faculty of Health, University of TechnologySydney, Sydney, Australia
   Department of Medicine and Therapeutics (AYL, JCW),The Chinese University of Hong Kong
   and Chinese Medicine Department (ETZ, BFN),Hong Kong Hospital Authority, Hong Kong, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD MAR 6
PY 2016
VL 95
IS 9
BP e2901
EP e2901
DI 10.1097/MD.0000000000002901 
PG 1
WC Acupuncture Therapy; Humans; Neoplasms; Palliative Care; methods
UT PubMed:26945382
PM 26945382
DA 2016-03-06
ER

PT J
AU Kwon, CY
   Yeh, CH
AF Kwon, Chan-Young
   Yeh, Chao Hsing
TI Use of Information and Communication Technologies to Enhance Self-Acupressure: a 
SO Journal of acupuncture and meridian studies
LA English
DT Review
DE Acupressure; East Asian traditional medicine; Information and communication technologies; Review; Telecommunications
AB Currently, acupressure is widely accepted as a non-pharmacological therapy for 
   managing pain, nausea and vomiting, and mental health conditions. Since 
   acupressure can be self-administered, clinicians and researchers' interest in 
   information and communication technologies (ICTs) for disseminating acupressure 
   to manage symptoms has increased. This mini review was conducted to examine 
   clinical studies of acupressure using ICTs, with a particular focus on 
   self-acupressure. Through a search of MEDLINE, EMBASE, and CENTRAL, all studies 
   of self-acupressure using ICTs published before December 31, 2021 were collected. 
   Twelve studies met the inclusion criteria. More than half of the studies 
   published since 2020 (4/7, 54.14%) were described as being related to COVID-19. 
   As target conditions, musculoskeletal injuries or pain, cancer-related symptoms, 
   dysmenorrhea, mental health issues, and obesity were considered. The most 
   frequently used acupoints were LI4, LR3, and Shenmen. Moreover, smartphone 
   applications were the most commonly used ICT method to support self-acupressure. 
   In addition to the basic information of self-acupressure, other tools such as 
   timers, reminders, and schedule checkers to facilitate its implementations have 
   been incorporated into the smartphone applications. Recently, there have been 
   some attempts to combine acupressure and ICTs. Although these studies mainly 
   focus on musculoskeletal pain or injuries, recent studies related to mental 
   health have emerged in relation to COVID-19. However, few studies have been 
   conducted to date, making it difficult to fully grasp the trends in this field. 
   Therefore, more studies are needed to evaluate the feasibility and efficacy of 
   combining self-acupressure and ICTs in more diverse clinical areas.
C1 Department of Oriental Neuropsychiatry, Dong-Eui University College of Korean Medicine, Busan, Korea.
   Cizik School of Nursing, University of Texas Health Science Center at Houston, Houston, TX, USA.
NR 0
TC 0
SN 2093-815
EI 
J9 J Acupunct Meridian Stud
PD DEC 16
PY 2022
VL 15
IS 4
BP 214
EP 226
DI 10.51507/j.jams.2022.15.4.214 
PG 12
WC Female; Humans; Acupressure; methods; COVID-19; therapy; Nausea; therapy; Vomiting; therapy; Communication
UT PubMed:36521770
PM 36521770
DA 2022-12-16
ER

PT J
AU Yang, M
   Zhong, L
   Fok, RWY
   Tjioe, YY
   Teo, BS
   Zhang, F
   Bao, T
AF Yang, Mingxiao
   Zhong, Linda
   Fok, Rose W Y
   Tjioe, Yan Yin
   Teo, Bo Siang
   Zhang, Furong
   Bao, Ting
TI Effects and safety of traditional Chinese medicine approaches in cancer symptom 
SO Cancer
LA English
DT Journal Article
DE Tai Chi; acupuncture; herbal therapies; neoplasms; phase 3 clinical trials; symptom burden; systematic review; traditional Chinese medicine
AB Cancer-related symptoms are detrimental to the quality of life of people with 
   cancer. This review systematically evaluates phase 3 randomized clinical trials 
   (RCTs) assessing the effectiveness and safety of traditional Chinese medicine 
   (TCM) interventions in managing cancer-related symptoms throughout the cancer 
   care trajectory. A comprehensive literature search was conducted of PubMed, 
   Embase, and the Cochrane Library until April 27, 2025, to further identify 
   eligible RCTs involving patients with cancer or survivors and assessing TCM 
   interventions against valid control arms. Data extraction and quality assessments 
   were conducted in accordance with Cochrane standards and Preferred Reporting 
   Items for Systematic Reviews and Meta-Analyses guidelines. Nineteen phase 3 RCTs 
   involving 5387 participants (female, 3321; primarily breast, gastrointestinal, 
   and lung cancers) from six countries or regions were included. Nonpharmacological 
   interventions, namely acupuncture and Tai Chi, significantly reduced pain, 
   fatigue, insomnia, radiation-induced xerostomia, and hormonal therapy-related hot 
   flashes compared to usual care (UC). Their effects on preventing chemotherapy- 
   and radiotherapy-induced nausea and vomiting were mixed, which depended on 
   control arms and outcome measures. Conversely, evidence for pharmacological 
   interventions was limited, with inconclusive results regarding 
   chemotherapy-induced peripheral neuropathy and hematologic toxicities, although 
   promising outcomes were noted for preventing chemoradiotherapy-induced mucositis, 
   reducing colorectal adenoma recurrence, and enhancing chemotherapy completion 
   rates compared to placebo or UC. Safety data suggested similar adverse event 
   profiles across groups. These findings show strong evidence for the inclusion of 
   nonpharmacological interventions in oncology practice. However, pharmacological 
   interventions require more high-quality, multicenter research to fully understand 
   their effectiveness and safety. Implementing rigorous safety assessments and 
   standardized adverse event reporting protocols is crucial to enhance clinical 
   confidence in TCM modalities.
C1 School of Biological Sciences, Nanyang Technological University, Singapore.
   School of Biological Sciences, Nanyang Technological University, Singapore.
   Division of Medical Oncology, National Cancer Centre Singapore, Singapore.
   School of Biological Sciences, Nanyang Technological University, Singapore.
   School of Biological Sciences, Nanyang Technological University, Singapore.
   College of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.
NR 0
TC 0
SN 1097-014
EI 
J9 Cancer
PD NOV 11
PY 2025
VL 131
IS 22
BP e70170
EP e70170
DI 10.1002/cncr.70170 
PG 1
WC Female; Humans; Acupuncture Therapy; adverse effects; Clinical Trials, Phase III as Topic; Medicine, Chinese Traditional; methods; Neoplasms; therapy; Quality of Life; Randomized Controlled Trials as Topic
UT PubMed:41217297
PM 41217297
DA 2025-11-11
ER

PT J
AU Li, H
   Schlaeger, JM
   Patil, CL
   Danciu, OC
   Xia, Y
   Sun, J
   Doorenbos, AZ
AF Li, Hongjin
   Schlaeger, Judith M
   Patil, Crystal L
   Danciu, Oana C
   Xia, Yinglin
   Sun, Jun
   Doorenbos, Ardith Z
TI Feasibility of Acupuncture and Exploration of Metabolomic Alterations for 
SO Biological research for nursing
LA English
DT Journal Article
DE acupuncture; breast cancer; metabolites; psychoneurological symptoms
AB OBJECTIVE: Approximately 24-68% of breast cancer survivors report co-occurring 
   psychoneurological symptoms of pain, fatigue, sleep disturbance, depression, and 
   anxiety during and after cancer treatment. This study aimed to assess the 
   feasibility and acceptability of acupuncture for the treatment of multiple 
   psychoneurological symptoms among breast cancer survivors and explore metabolomic 
   changes before and after acupuncture. METHODS: We conducted a single-arm, 
   prospective pilot study of breast cancer survivors with at least two moderate to 
   severe psychoneurological symptoms (>3 on a 0-10 scale). Acupuncture was 
   administered twice weekly for 5 weeks, for 30 minutes per session. Along with 
   Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires, 
   a fasting serum comprehensive hydrophilic metabolites panel was analyzed at 
   baseline and after acupuncture. RESULTS: Eight participants (mean age 52.5 ± 
   10.9 years; 62.5% Black) were enrolled. Feasibility was supported, with 67% 
   recruitment, 87.5% retention, and 98% acceptability. Post intervention, PROMIS 
   T-scores were reduced for all psychoneurological symptoms. Significant 
   differences in serum metabolites before and after acupuncture were F-1,6/2,6-DP, 
   glutathione disulfide, phosphorylcholine, 6-methylnicotinamide, glutathione, and 
   putrescine (variable importance of projection values larger than 1.5 and p values 
   <0.05). Pathway analysis indicated that glutathione metabolism (p = 0.002, q = 
   0.071), and arginine and proline metabolisms (p = 0.009, q = 0.166) were 
   potentially involved in mechanisms of acupuncture. CONCLUSIONS: Acupuncture to 
   reduce multiple psychoneurological symptoms among breast cancer survivors was 
   feasible and acceptable. Study findings also shed light on the metabolic pathways 
   involved in the acupuncture response and will be tested in future studies.
C1 Department of Human Development Nursing Science, College of Nursing, 14681University of Illinois Chicago, Chicago, IL, USA.
   Cancer Center, 14681University of Illinois Chicago, Chicago, IL, USA.
   Department of Human Development Nursing Science, College of Nursing, 14681University of Illinois Chicago, Chicago, IL, USA.
   Department of Human Development Nursing Science, College of Nursing, 14681University of Illinois Chicago, Chicago, IL, USA.
   Cancer Center, 14681University of Illinois Chicago, Chicago, IL, USA.
   College of Medicine, 14681University of Illinois Chicago, Chicago, IL, USA.
   College of Medicine, 14681University of Illinois Chicago, Chicago, IL, USA.
   Cancer Center, 14681University of Illinois Chicago, Chicago, IL, USA.
   College of Medicine, 14681University of Illinois Chicago, Chicago, IL, USA.
   Cancer Center, 14681University of Illinois Chicago, Chicago, IL, USA.
   Department of Biobehavioral Nursing Science, College of Nursing, 14681University 
NR 0
TC 0
SN 1552-417
EI 1099-800
J9 Biol Res Nurs
PD OCT 29
PY 2022
VL 25
IS 2
BP 326
EP 335
DI 10.1177/10998004221136567 
PG 9
WC Humans; Adult; Middle Aged; Female; Breast Neoplasms; complications; Cancer Survivors; Prospective Studies; Pilot Projects; Feasibility Studies; Acupuncture Therapy
UT PubMed:36306737
PM 36306737
DA 2022-10-29
ER

PT J
AU Paley, CA
   Johnson, MI
AF Paley, Carole A
   Johnson, Mark I
TI Acupuncture for cancer-induced bone pain: a pilot study.
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Letter
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD FEB 8
PY 2011
VL 29
IS 1
BP 71
EP 3
DI 10.1136/aim.2010.003087 
PG -68
WC Acupuncture Therapy; methods; Aged; Aged, 80 and over; Bone and Bones; innervation; Female; Humans; Male; Middle Aged; Neoplasms; complications; Pain; etiology; Pain Management; Pain Measurement; Pilot Projects; Treatment Outcome
UT PubMed:21297175
PM 21297175
DA 2011-02-08
ER

PT J
AU Thompson, LM
   Osian, SR
   Jacobsen, PB
   Johnstone, PA
AF Thompson, Lora M A
   Osian, Sarah Rausch
   Jacobsen, Paul B
   Johnstone, Peter A S
TI Patient-reported Outcomes of Acupuncture for Symptom Control in Cancer.
SO Journal of acupuncture and meridian studies
LA English
DT Journal Article
DE acupuncture; cancer symptom management; patient-reported outcomes; quality of life; satisfaction
AB Acupuncture is increasingly offered as a treatment option for managing 
   cancer-related symptoms. In addition to randomized controlled trials, 
   patient-reported outcomes may be needed to establish treatment effectiveness. 
   This study retrospectively examined the symptoms and the satisfaction ratings of 
   90 patients receiving acupuncture at an integrative oncology clinic. At least two 
   acupuncture sessions were completed by 72% of the sample. The prevalence rates of 
   fatigue, pain, anxiety, physical distress, emotional distress, and poor quality 
   of life before acupuncture were > 62%. Paired t tests revealed a significant 
   reduction in symptoms from baseline until after the first acupuncture session and 
   after the last session (p < 0.05). Fewer (21%) patients reported nausea, which 
   was significantly reduced after the first session, but not the last session. 
   Reductions represented clinically meaningful differences in 33-41% of patients 
   after the first session and in 41-53% of patients after the last session for all 
   symptoms, except nausea. A small subset of patients (0-8%) reported worsening 
   symptoms after acupuncture. The majority were satisfied with the service. The 
   results of this study suggest that acupuncture may be useful as an adjunct 
   treatment for cancer symptom management. While high-quality trials are still 
   needed to establish the treatment's efficacy, patients may benefit from these 
   primarily safe, low-cost services.
C1 H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA. 
   Center for Health Equity and Quality Research, Department of Emergency Medicine, Divisions of Palliative Care and Corporate Wellness, University of FloridaJacksonville, Jacksonville, USA.
   H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA.
   H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA.
EM lora.thompson@moffitt.org
NR 0
TC 0
SN 2093-815
EI 
J9 J Acupunct Meridian Stud
PD JUN 24
PY 2015
VL 8
IS 3
BP 127
EP 33
DI 10.1016/j.jams.2015.04.002 
PG -94
WC Acupuncture Therapy; Adult; Aged; Fatigue; Female; Humans; Male; Middle Aged; Nausea; Neoplasms; psychology; Pain; Patient Outcome Assessment; Patient Satisfaction; Quality of Life; Retrospective Studies; Young Adult
UT PubMed:26100066
PM 26100066
DA 2015-06-24
ER

PT J
AU Zhang, Y
   Wang, X
   Wang, L
   Tang, D
   Wei, W
   Tian, Y
AF Zhang, Yufei
   Wang, Xinyi
   Wang, Leisheng
   Tang, Di
   Wei, Wei
   Tian, Yuansheng
TI [Effects of Zhoutian moxibustion on pain symptoms and inflammatory factors in 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE Zhoutian moxibustion; ankylosing spondylitis, cold-damp obstruction; governor vessel moxibustion; inflammatory factors; moxibustion; pain symptoms; randomized controlled trial (RCT)
AB OBJECTIVE: To observe the effects of Zhoutian moxibustion on pain symptoms and 
   serum inflammatory factors in patients with ankylosing spondylitis of cold-damp 
   obstruction. METHODS: Eighty-four patients with ankylosing spondylitis of 
   cold-damp obstruction were randomly divided into a Zhoutian moxibustion group (42 
   cases, 2 cases dropped out) and a governor vessel moxibustion group (42 cases, 2 
   cases dropped out, 1 case discontinued). Both groups were given oral 
   administration of sulfasalazine enteric-coated tablets as basic treatment. The 
   governor vessel moxibustion group was treated with moxibustion box from Dazhui 
   (GV 14) to Yaoyangguan (GV 3), one hour per treatment; the Zhoutian moxibustion 
   group was treated with moxibustion box from Tiantu (CV 22) to Zhongji (CV 3) in 
   addition to the governor vessel moxibustion group, two hours per treatment. Both 
   groups were treated once every 3 days, twice a week, for a total of 9 weeks. The 
   pain symptom scores of the two groups were observed before treatment and at the 
   3rd, 6th, and 9th weeks into treatment. ELISA was used to detect the levels of 
   serum interleukin (IL)-1β, IL-18, and tumor necrosis factor-α (TNF-α) before and 
   after treatment, and the clinical efficacy of the two groups was evaluated after 
   treatment. RESULTS: Except for the joint pain scores at the 3rd week into 
   treatment, the total scores and the each sub-item score of pain symptom in the 
   two groups were lower than those before treatment at the 3rd, 6th, and 9th weeks 
   into treatment (P<0.05); at the 3rd, 6th, and 9th weeks into treatment, the total 
   scores of pain symptom and the scores of lumbar sacral pain, back pain, joint 
   cold pain, and limited mobility in the Zhoutian moxibustion group were lower than 
   those in the governor vessel moxibustion group (P<0.05). After treatment, the 
   levels of serum IL-1β, IL-18 and TNF-α in both groups were lower than those 
   before treatment (P<0.05), and the levels of serum IL-1β, IL-18, and TNF-α in the 
   Zhoutian moxibustion group were lower than those in the governor vessel 
   moxibustion group (P<0.05). The total effective rate was 90.0% (36/40) in the 
   Zhoutian moxibustion group, which was higher than 76.9% (30/39) in the governor 
   vessel moxibustion group (P<0.05). CONCLUSION: Zhoutian moxibustion could 
   effectively improve various pain symptoms in patients with ankylosing spondylitis 
   of cold-damp obstruction, and reduce the expression of inflammatory factors.
C1 Department of Pain and Rheumatology, Henan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Zhengzhou 450004, China.
   Department of Pain and Rheumatology, Henan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Zhengzhou 450004, China.
   Department of Pain and Rheumatology, Henan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Zhengzhou 450004, China.
   Dengzhou City Hospital of TCM.
   Department of Pain and Rheumatology, Henan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Zhengzhou 450004, China.
   Department of Pain and Rheumatology, Henan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Zhengzhou 450004, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUL 11
PY 2024
VL 44
IS 7
BP 797
EP 802
DI 10.13703/j.0255-2930.20230616-k0001 
PG 5
WC Humans; Moxibustion; Male; Female; Adult; Spondylitis, Ankylosing; therapy; Middle Aged; Young Adult; Acupuncture Points; Tumor Necrosis Factor-alpha; blood; Interleukin-1beta; blood; Adolescent; Interleukin-18; blood; Pain Management
UT PubMed:38986593
PM 38986593
DA 2024-07-11
ER

PT J
AU Bauml, J
   Basal, C
   Mao, JJ
AF Bauml, Joshua
   Basal, Coby
   Mao, Jun J
TI Treatment of post-mastectomy pain syndrome with acupuncture: a case report.
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE Oncology
AB Post-mastectomy pain syndrome (PMPS) is a common and severe neuropathic pain 
   syndrome arising after breast surgery. Since few effective allopathic treatments 
   exist for PMPS, many patients may seek assistance from complementary and 
   alternative medicine. Here, we report a case of a woman with severe and 
   persistent PMPS who was successfully treated with acupuncture.
C1 Division of Hematology/Oncology, Perelman School of Medicine at the University of Pennsylvania, , Philadelphia, Pennsylvania, USA.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD NOV 19
PY 2013
VL 32
IS 2
BP 183
EP 5
DI 10.1136/acupmed-2013-010459 
PG -178
WC Acupuncture Therapy; Breast Neoplasms; surgery; Female; Humans; Mastectomy; adverse effects; Middle Aged; Pain, Postoperative; etiology; Treatment Outcome
UT PubMed:24240772
PM 24240772
DA 2013-11-19
ER

PT J
AU Fu, YM
   Yang, YC
   Zhang, J
   Zhao, J
   Liu, GY
   Ling, S
   Wang, C
   Wang, LW
   Yang, YT
   Wang, Y
   Yang, NN
   Liu, CZ
   Pei, W
AF Fu, Yi-Ming
   Yang, Ying-Chi
   Zhang, Jing
   Zhao, Jingjie
   Liu, Gong-Yong
   Ling, Shen
   Wang, Chao
   Wang, Li-Wei
   Yang, Yu-Tong
   Wang, Yu
   Yang, Na-Na
   Liu, Cun-Zhi
   Pei, Wei
TI Preoperative electroacupuncture versus sham electroacupuncture for the treatment 
SO BMJ open
LA English
DT Journal Article
DE colorectal surgery; complementary medicine; gastroenterology
AB INTRODUCTION: Postoperative ileus (POI) is a postoperative complication that can 
   cause lingering recovery after colorectal resection and a heavy healthcare system 
   burden. Acupuncture aims to prevent postoperative complications, reduce the 
   duration of POI, help recovery and shorten hospital stays. We hypothesise that 
   preoperative electroacupuncture (EA) can promote POI recovery under the enhanced 
   recovery after surgery protocol after laparoscopic surgery in patients with POI. 
   METHODS AND ANALYSIS: This is a multicentre, randomised, sham-controlled trial. A 
   total of 80 patients will be enrolled and randomly assigned to the EA or sham 
   electroacupuncture (SA) group. The eligible patients will receive EA or SA for 
   one session per day with treatment frequency starting on preoperative day 1 for 
   four consecutive days. The primary outcome is the time to first defecation. The 
   secondary outcomes include the time to first flatus, length of postoperative 
   hospital stay, time to tolerability of semiliquid and solid food, postoperative 
   nausea, vomiting, pain and extent of abdominal distention, time to first 
   ambulation, preoperative anxiety, 30-day readmission rate, the usage of 
   anaesthetics and analgesics during operation, length of postanaesthesia care unit 
   stay. A mechanistic study by single-cell RNA sequencing in which postintervention 
   normal intestinal tissue samples will be collected. The results of this study 
   will provide evidence of the effects of acupuncture on POI and promote good 
   clinical decision to millions of patients globally every year. ETHICS AND 
   DISSEMINATION: This study has been approved by the ethical application of Beijing 
   University of Chinese Medicine (2022BZYLL0401), Beijing Friendship Hospital 
   Affiliated to Capital Medical University(2022-P2-368-02), Cancer Hospital Chinese 
   Academy of Medical Science (23/175-3917), Huanxing Cancer Hospital (2023-002-02). 
   The results will be published in a medical journal. In addition, we plan to 
   present them at scientific conferences. TRIAL REGISTRATION NUMBER: 
   ChiCTR2300077633.
C1 International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
   Department of Surgery, Huanxing Cancer Hospital, Beijing, China.
   Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
   Department of Surgery, Huanxing Cancer Hospital, Beijing, China.
   Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
   Department of Surgery, Huanxing Cancer Hospital, Beijing, China.
   Department of Surgery, Huanxing Cancer Hospital, Beijing, China.
   Department of Surgery, Huanxing Cancer Hospital, Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China lcz623780@126.com peiwei1@sina.com.
   Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciencesand Peking Union Medical College, Beijing, China lcz623780@126.compeiwei1@sina.com.
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD JUL 6
PY 2024
VL 14
IS 7
BP e083460
EP e083460
DI 10.1136/bmjopen-2023-083460 
PG 1
WC Humans; Electroacupuncture; methods; Laparoscopy; adverse effects; Ileus; etiology; Colorectal Neoplasms; surgery; Postoperative Complications; therapy; China; Length of Stay; statistics & numerical data; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Preoperative Care; methods; Female; Adult; Male
UT PubMed:38969370
PM 38969370
DA 2024-07-06
ER

PT J
AU Meng, ZQ
   Garcia, MK
   Chiang, JS
   Peng, HT
   Shi, YQ
   Fu, J
   Liu, LM
   Liao, ZX
   Zhang, Y
   Bei, WY
   Thornton, B
   Palmer, JL
   McQuade, J
   Cohen, L
AF Meng, Zhi-Qiang
   Garcia, M Kay
   Chiang, Joseph S
   Peng, Hui-Ting
   Shi, Ying-Qiang
   Fu, Jie
   Liu, Lu-Ming
   Liao, Zhong-Xing
   Zhang, Ying
   Bei, Wen-Ying
   Thornton, Bob
   Palmer, J Lynn
   McQuade, Jennifer
   Cohen, Lorenzo
TI Electro-acupuncture to prevent prolonged postoperative ileus: a randomized 
SO World journal of gastroenterology
LA English
DT Journal Article
AB AIM: To examine whether acupuncture can prevent prolonged postoperative ileus 
   (PPOI) after intraperitoneal surgery for colon cancer. METHODS: Ninety patients 
   were recruited from the Fudan University Cancer Hospital, Shanghai, China. After 
   surgery, patients were randomized to receive acupuncture (once daily, starting on 
   postoperative day 1, for up to six consecutive days) or usual care. PPOI was 
   defined as an inability to pass flatus or have a bowel movement by 96 h after 
   surgery. The main outcomes were time to first flatus, time to first bowel 
   movement, and electrogastroenterography. Secondary outcomes were quality of life 
   (QOL) measures, including pain, nausea, insomnia, abdominal distension/fullness, 
   and sense of well-being. RESULTS: No significant differences in PPOI on day 4 (P 
   = 0.71) or QOL measures were found between the groups. There were also no group 
   differences when the data were analyzed by examining those whose PPOI had 
   resolved by day 5 (P = 0.69) or day 6 (P = 0.88). No adverse events related to 
   acupuncture were reported. CONCLUSION: Acupuncture did not prevent PPOI and was 
   not useful for treating PPOI once it had developed in this population.
C1 Department of Integrative Oncology, Fudan University Cancer Hospital, Shanghai 200032, China.
NR 0
TC 0
SN 2219-284
EI 1007-932
J9 World J Gastroenterol
PD DEC 30
PY 2009
VL 16
IS 1
BP 104
EP 11
DI 10.3748/wjg.v16.i1.104 
PG -93
WC Adult; Aged; Colectomy; adverse effects; Colonic Neoplasms; surgery; Defecation; Electroacupuncture; Female; Gastrointestinal Motility; Humans; Ileus; etiology; Male; Middle Aged; Pain, Postoperative; etiology; Postoperative Nausea and Vomiting; etiology; Prospective Studies; Quality of Life; Recovery of Function; Sleep Initiation and Maintenance Disorders; etiology; Time Factors; Treatment Failure
UT PubMed:20039456
PM 20039456
DA 2009-12-30
ER

PT J
AU Chiu, WS
   Lu, YW
   Lien, TH
AF Chiu, Wen-Shan
   Lu, Yu-Wen
   Lien, Ting-Hsuan
TI Iatrogenic Pneumothorax during Acupuncture: Case Report.
SO Medicina (Kaunas, Lithuania)
LA English
DT Journal Article
DE acupuncture; chronic pulmonary diseases; iatrogenic pneumothorax; imaging
AB Acupuncture treatment in local areas is commonly used to treat pain or soreness; 
   however, acupuncture around the neck or shoulder may be a risk factor for 
   pneumothorax. Herein, we report two cases of iatrogenic pneumothorax after 
   acupuncture. These points indicate that physicians should be aware of these risk 
   factors through history-taking before acupuncture. Chronic pulmonary diseases, 
   such as chronic bronchitis, emphysema, tuberculosis, lung cancer, pneumonia, and 
   thoracic surgery, may be associated with a higher risk of iatrogenic pneumothorax 
   after acupuncture. Even if the incidence of pneumothorax should be low under 
   caution and fully evaluated, it is still recommended to arrange further imaging 
   examinations to rule out the possibility of iatrogenic pneumothorax.
C1 Department of Chinese Medicine, Show Chawn Memorial Hospital, Changhua 500, Taiwan.
   Department of Chinese Medicine, Show Chawn Memorial Hospital, Changhua 500, Taiwan.
   Department of Chinese Medicine, Show Chawn Memorial Hospital, Changhua 500, Taiwan.
NR 0
TC 0
SN 1648-914
EI 1010-660
J9 Medicina (Kaunas)
PD JUN 28
PY 2023
VL 59
IS 6
BP 
EP 
DI 10.3390/medicina59061100 
PG 0
WC Humans; Pneumothorax; etiology; Acupuncture Therapy; adverse effects; Pain; etiology; Pulmonary Emphysema; complications; Iatrogenic Disease
UT PubMed:37374304
PM 37374304
DA 2023-06-28
ER

PT J
AU Wang, P
   Wang, LY
   Xie, SM
   Wang, LL
   Wang, HE
   Yu, JX
   Chang, YZ
   Zhu, WJ
AF Wang, Pei
   Wang, Liu-Yu
   Xie, Shun-Ming
   Wang, Li-Li
   Wang, Hong-En
   Yu, Jian-Xin
   Chang, Yong-Zhi
   Zhu, Wei-Jie
TI Effect of moxibustion for "nourishing the kidney and benefiting the marrow" on 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Bone metabolism; Inflammatory factors; Knee osteoarthritis; Moxibustion
AB OBJECTIVES: To compare the clinical effect between two acupoint regimens of 
   moxibustion on knee osteoarthritis (KOA), and observe the influences on the serum 
   content of interleukin 1α (IL-1α), interleukin-17A (IL-17A), tumor necrosis 
   factor α (TNF-α), bone gla protein (BGP) and osteoprotegerin (OPG). METHODS: KOA 
   patients were randomly divided into an observation group (40 cases, 2 cases 
   dropped off) and a control group (40 cases, 3 cases dropped off). In the 
   observation group, moxibustion was applied to Xiyan (EX-LE5), Dubi (ST35), 
   Zusanli (ST36), Dazhu (BL11), Xuanzhong (GB39) and Yongquan (KI1) on the affected 
   side. In the control group, EX-LE5, ST35 and ST36 were selected on the affected 
   side. One session of treatment took 30 min in each group, delivered 3 times a 
   week and the duration of treatment was 4 weeks. The scores of Western Ontario and 
   McMaster University (WOMAC) and visual analogue scale (VAS) were observed and the 
   serum content of IL-1α, IL-17A, TNF-α, BGP and OPG of the two groups were 
   measured before and after treatment. RESULTS: Compared with those before 
   treatment, the WOMAC score, VAS score and the serum content of IL-1α, IL-17A and 
   TNF-α were decreased (P<0.05), and the content of BGP and OPG were increased 
   (P<0.05) after treatment. Compared with the control group, the WOMAC score, VAS 
   score and the serum content of IL-1α and TNF-α in the observation group were 
   lower (P<0.05), and the content of BGP and OPG were higher (P<0.05). The total 
   effective rate of the observation group was 89.5% (34/38), and that of the 
   control group was 83.8% (31/37), with no statistically significant difference. 
   CONCLUSIONS: Moxibustion therapy of "nourishing the kidney and benefiting the 
   marrow" can relieve joint pain, improve joint function, reduce the level of 
   inflammatory factors and ameliorate bone metabolic indicators. The effect of the 
   acupoint regimen in this moxibustion therapy is better than that of the local 
   acupoint selection.
C1 Rehabilitation Medicine Center of Taihu Rehabilitation Hospital of Jiangsu Province, Taihu Sanatorium of Jiangsu Province, Jiangsu Provincial ResearchCenter for Health Assessment and Intervention, Wuxi 214026, Jiangsu Province,China.
   Rehabilitation Medicine Center of Taihu Rehabilitation Hospital of Jiangsu Province, Taihu Sanatorium of Jiangsu Province, Jiangsu Provincial ResearchCenter for Health Assessment and Intervention, Wuxi 214026, Jiangsu Province,China.
   Rehabilitation Medicine Center of Taihu Rehabilitation Hospital of Jiangsu Province, Taihu Sanatorium of Jiangsu Province, Jiangsu Provincial ResearchCenter for Health Assessment and Intervention, Wuxi 214026, Jiangsu Province,China.
   Rehabilitation Medicine Center of Taihu Rehabilitation Hospital of Jiangsu Province, Taihu Sanatorium of Jiangsu Province, Jiangsu Provincial ResearchCenter for Health Assessment and Intervention, Wuxi 214026, Jiangsu Province,China.
   Rehabilitation Medicine Center of Taihu Rehabilitation Hospital of Jiangsu Province, Taihu Sanatorium of Jiangsu Province, Jiangsu Provincial ResearchCenter for Health Assessment and Intervention, Wuxi 214026, Jiangsu Province,China.
   Rehabilitation Medicine Center of Taihu Rehabilitation Hospital of Jiangsu Province, Taihu Sanatorium of Jiangsu Province, Jiangsu Provincial ResearchCenter for Health Assessment and Intervention, Wuxi 214026, Jiangsu Province,China.
   Rehabilitation Medicine Center of Taihu Rehabilitation Hospital of Jiangsu Province, Taihu Sanatorium of Jiangsu Province, Jiangsu Provincial ResearchCenter for Health Assessment and Intervention, Wuxi 214026, Jiangsu Province,China.
   Rehabilitation Medicine Center of Taihu Rehabilitation Hospital of Jiangsu Province, Taihu Sanatorium of Jiangsu Province, Jiangsu Provincial ResearchCenter for Health Assessment and Intervention, Wuxi 214026, Jiangsu Province,China. ymsz1529@163.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD FEB 28
PY 2024
VL 49
IS 2
BP 171
EP 176
DI 10.13702/j.1000-0607.20221256 
PG 5
WC Humans; Moxibustion; Osteoarthritis, Knee; therapy; Interleukin-17; Bone Marrow; Tumor Necrosis Factor-alpha; Treatment Outcome; Acupuncture Points; Kidney
UT PubMed:38413038
PM 38413038
DA 2024-02-28
ER

PT J
AU Kim, K
   Lee, S
AF Kim, Kyungsuk
   Lee, Sanghun
TI Intradermal Acupuncture Along with Analgesics for Pain Control in Advanced Cancer 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; advanced cancer; analgesics; intradermal; pain management
AB PURPOSE: Ninety percent of patients with advanced cancer have moderate to severe 
   pain, and up to 70% of patients with cancer pain do not receive adequate pain 
   relief. This randomized controlled clinical trial was designed to determine the 
   feasibility and evaluate the effects and safety of intradermal acupuncture (IA) 
   in patients who were being administered analgesics for cancer pain. METHODS: 
   Advanced cancer patients experiencing pain were randomly assigned to IA or sham 
   IA treatment for 3 weeks (15 patients for each group), wherein the CV12, 
   bilateral ST25, LI4, LR3, PC06, and Ashi points were selected and stimulated. 
   Follow-up evaluations were conducted 3 weeks after the end of treatments. The 
   grade and dosage of analgesics for cancer pain, pain intensity, quality of life, 
   and safety were assessed. RESULTS: Twenty-seven patients (90%) completed 6-week 
   trial, and no serious adverse events were associated with either IA or sham IA 
   procedures except the transient side effect such as fatigue. Nine patients in the 
   IA group (64.3%) and 5 in the sham IA group (38.5%) responded to the 3-week 
   intervention. These patients were mostly in the nonopioid and the weak opioid 
   levels of the World Health Organization analgesic ladder. Self-reported pain 
   declined by -1.54 ± 1.45 and -1.15 ± 1.57 in the IA and sham IA groups, 
   respectively, with improved quality of life reported. CONCLUSIONS: IA treatment 
   appears feasible and safe for advanced cancer patients. It might reduce analgesic 
   usage in the early World Health Organization analgesic ladder stage cancer 
   patient, though it could not show significant outcome differences due to design 
   limitation of sham IA.
C1 1 Department of Medical Consilience, Graduate school, Dankook University, Yongin-si, Republic of Korea.
   1 Department of Medical Consilience, Graduate school, Dankook University, Yongin-si, Republic of Korea.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD JUL 17
PY 2018
VL 17
IS 4
BP 1137
EP 1143
DI 10.1177/1534735418786797 
PG 6
WC Acupuncture Therapy; methods; Analgesics; therapeutic use; Fatigue; therapy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasms; complications; Pain; drug therapy; Pain Management; methods; Pain Measurement; methods; Pilot Projects; Quality of Life; World Health Organization
UT PubMed:30009652
PM 30009652
DA 2018-07-17
ER

PT J
AU Tang, J
   Wu, P
   Yu, ZY
   Wang, X
   Tao, SY
   Jiang, NN
   Chen, GH
   Shuai, RX
AF Tang, Jie
   Wu, Ping
   Yu, Ze-Yun
   Wang, Xue
   Tao, Si-Yu
   Jiang, Nan-Nan
   Chen, Guan-Hua
   Shuai, Rou-Xian
TI [Regulatory effect of moxibustion on LTB4/MMP-9 in serum of patients with 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Interleukin -17; Leukotriene B4; Matrix metalloproteinase-9; Moxibustion; Rheumatoid arthritis; Tumor necrosis factor-α
AB OBJECTIVE: To observe the effects of moxibustion on the contents of leukotriene 
   B4 (LTB4), interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α) and matrix 
   metalloproteinase -9 (MMP-9) in serum, and explore the protection mechanisms of 
   moxibustion in the patients with rheumatoid arthritis (RA). METHODS: A total of 
   64 patients with RA were randomly divided into treatment group (n=31) and control 
   group (n=33). The patients in the control group were treated with conventional 
   medication for consecutive 5 weeks. Based on the treatment in the control group, 
   the patients in the treatment group were treated with moxibustion at bilateral 
   Shenshu (BL23), Zusanli (ST36) and Ashi points, 3 times a week, for consecutive 5 
   weeks. Separately, the visual analogue scale (VAS) score, morning stiffness 
   score, the number of tender joints, the number of swollen joints, the score of 
   the disease activity score of 28 joints (DAS28) were observed; the contents of 
   rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) and C-reative 
   protein (CRP) in serum were determined by biochemical method; and the contents of 
   LTB4, IL-17, TNF-α and MMP-9 in serum were detected by using ELISA before and 
   after treatment in the patients of both groups. RESULTS: After treatment, VAS 
   score, morning stiffness score, the number of tender joints, the number of 
   swollen joints, DAS28 score, the contents of serum RF in both groups, and 
   contents of serum CRP, ESR, LTB4, IL-17, TNF-α and MMP-9 in the treatment group 
   were significantly reduced when compared with those before treatment (P<0.01, 
   P<0.05). After treatment, VAS score, morning stiffness score, the number of 
   tender joints, the number of swollen joints, DAS28 score, and the levels of LTB4, 
   IL-17 and MMP-9 in serum were obviously lower in the treatment group when 
   compared with the control group (P<0.01, P<0.05). In the treatment group, the 
   changes before and after treatment in the levels of LTB4, IL-17 and TNF-α were 
   positively correlated with that of MMP-9 (P<0.05, r>0). CONCLUSION: Moxibustion 
   at BL23 and ST36 combined with conventional medication significantly relieves 
   joint pain and reduce disease activity in RA patients, which may be related to 
   the modulation of LTB4, IL-17 and MMP-9 by moxibustion.
C1 College of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
   The First People's Hospital of Yibin City, Yibin 644099, Sichuan Province.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
   College of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
   1College of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
   2The First People's Hospital of YibinCity, Yibin 644099, Sichuan Province.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD MAY 30
PY 2023
VL 48
IS 5
BP 488
EP 93
DI 10.13702/j.1000-0607.20220088 
PG -395
WC Humans; Leukotriene B4; Moxibustion; Interleukin-17; genetics; Tumor Necrosis Factor-alpha; genetics; Matrix Metalloproteinase 9; genetics; Arthritis, Rheumatoid; genetics
UT PubMed:37247863
PM 37247863
DA 2023-05-30
ER

PT J
AU Lagerstedt, K
   Efverman, A
AF Lagerstedt, Kristina
   Efverman, Anna
TI A Randomized Sham-Controlled Mixed Methods Pilot Study of the Feasibility of 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; cancer rehabilitation; complementary and alternative therapies; integrative oncology; neuropathy; neurotoxicity; nursing; pain; physiotherapy
AB OBJECTIVE: Since there is a lack of effective pharmacological therapies for 
   chemotherapy-induced neuropathy and many patients ask for integrative cancer 
   therapies such as acupuncture, the objective of this pilot study was to describe 
   patients' experiences, and to study the feasibility and short-term effects of 
   genuine acupuncture for chemotherapy-induced neuropathic pain and unpleasant 
   sensations compared to sham acupuncture. METHODS: The pilot study used mixed 
   methods, collecting quantitative and qualitative data. Patients (n = 12) with 
   chemotherapy-induced neuropathy after colorectal cancer were blindly randomized 
   to genuine acupuncture or telescopic sham acupuncture. Individual interviews were 
   conducted, and were analyzed using qualitative content analysis. The patients 
   registered pain and unpleasant sensations (100 mm Visual Analog Scales) before 
   and after n = 120 sessions, n = 60 genuine and n = 60 sham acupuncture sessions. 
   RESULTS: Five categories of patient experiences were described. The neuropathy 
   negatively affected life. Physical activity was perceived to be important for 
   health, but neuropathy was a barrier. The neuropathy required symptom-managing 
   strategies. Acupuncture was pleasant and valuable, but some patients presented 
   doubts regarding its effect mechanisms. After the genuine acupuncture sessions, 
   pain (mean -2.0 steps relief during each session) and unpleasant sensations 
   (-2.4) in the face was reduced more than after sham acupuncture (+0.1 steps worse 
   pain, P = .018, +0.1 steps worse unpleasant sensations, P = .036). After genuine 
   acupuncture, unpleasant sensations in the hands were reduced less (-0.23) 
   compared to after sham acupuncture (-5.5, P = .002). Pain or unpleasant 
   sensations in the feet did not change. CONCLUSIONS: Patients experienced that the 
   neuropathy negatively changed their life and that acupuncture was pleasant and 
   valuable. Patients receiving genuine acupuncture had short-term effects regarding 
   pain and unpleasant sensations in the face compared to patients receiving sham 
   acupuncture, while hands and feet did not improve. The patients were successfully 
   blinded and complied with the acupuncture. We welcome future full-scaled 
   randomized sham-controlled acupuncture studies.
C1 Region of Kronoberg, Växjö, Sweden.
   University of Gävle, Gävle, Sweden.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD JUN 9
PY 2023
VL 22
IS 
BP 15347354231178877
EP 15347354231178877
DI 10.1177/15347354231178877 
PG 1
WC Humans; Pilot Projects; Feasibility Studies; Acupuncture Therapy; methods; Peripheral Nervous System Diseases; therapy; Pain; chemically induced; Antineoplastic Agents; adverse effects; Patient Outcome Assessment; Neoplasms; drug therapy
UT PubMed:37294052
PM 37294052
DA 2023-06-09
ER

PT J
AU Giron, PS
   Haddad, CA
   Lopes, de Almeida Rizzi SK
   Nazário, AC
   Facina, G
AF Giron, Patricia Santolia
   Haddad, Cinira Assad Simão
   Lopes de Almeida Rizzi, Samantha Karlla
   Nazário, Afonso Celso Pinto
   Facina, Gil
TI Effectiveness of acupuncture in rehabilitation of physical and functional 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture; Breast cancer; Depression; Rehabilitation; Upper limb function
AB PURPOSE: The purpose of the study is to verify the effectiveness of acupuncture 
   in rehabilitation of physical and functional disorders of women undergoing breast 
   cancer surgery on the following parameters: pain, range of motion, upper limb 
   function, and depressive symptoms. METHODS: The following are the inclusion 
   criteria: women aged more than 18 years with scapular girdle and upper limb pain 
   after 3 months of surgery and with pain ≥3 in visual analog scale. Patients were 
   divided into two randomized groups which received weekly treatment during 10 
   sessions. Kinesiotherapy group (G1)-treated with a predefined kinesiotherapy 
   protocol of 30 min. Group Acupuncture + Kinesiotherapy (G2)-treated with the same 
   kinesiotherapy group protocol followed by another 30 min of acupuncture, used in 
   predefined points. Both groups performed physical examination and answered the 
   upper limb function and depressive symptoms questionnaires. RESULTS: Forty-eight 
   patients completed the treatment, 24 in each group. Regarding the pain, the two 
   groups had statistically significant improvement in all evaluated moments. In the 
   analysis of depression, it improved significantly only in G1 in the comparison 
   between the first and the tenth session. The upper limb function had improvement 
   in G1 only in the comparison between the first and the tenth session and in G2, 
   in the three evaluation moments. The range of motion (ROM) showed improvement in 
   all evaluated movements. CONCLUSIONS: There was no difference between groups. 
   Both groups showed statistically significant improvement of the items assessed: 
   pain, depression, upper limb function, and ADM, and there was no difference 
   between them.
C1 , Rua Marselhesa, 249- Vila Mariana, São Paulo, SP, Brazil, 04020060. patysantolia@hotmail.com.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD DEC 17
PY 2015
VL 24
IS 6
BP 2491
EP 6
DI 10.1007/s00520-015-3054-5 
PG -2485
WC Acupuncture Therapy; methods; Adult; Aged; Arm; physiopathology; Breast Neoplasms; physiopathology; Depression; etiology; Female; Humans; Male; Middle Aged; Pain Measurement; Range of Motion, Articular; Treatment Outcome
UT PubMed:26670916
PM 26670916
DA 2015-12-17
ER

PT J
AU Tick, H
   Nielsen, A
   Pelletier, KR
   Bonakdar, R
   Simmons, S
   Glick, R
   Ratner, E
   Lemmon, RL
   Wayne, P
   Zador, V
AF Tick, Heather
   Nielsen, Arya
   Pelletier, Kenneth R
   Bonakdar, Robert
   Simmons, Samantha
   Glick, Ronald
   Ratner, Emily
   Lemmon, Russell L
   Wayne, Peter
   Zador, Veronica
TI Evidence-Based Nonpharmacologic Strategies for Comprehensive Pain Care: The 
SO Explore (New York, N.Y.)
LA English
DT Journal Article
DE Acute Pain Management; Chronic Pain Management; Evidence-Based Practice in Health Care System; Integrative Medicine; Non Surgical Pain Management; Public Health
AB Medical pain management is in crisis; from the pervasiveness of pain to 
   inadequate pain treatment, from the escalation of prescription opioids to an 
   epidemic in addiction, diversion and overdose deaths. The rising costs of pain 
   care and managing adverse effects of that care have prompted action from state 
   and federal agencies including the DOD, VHA, NIH, FDA and CDC. There is pressure 
   for pain medicine to shift away from reliance on opioids, ineffective procedures 
   and surgeries toward comprehensive pain management that includes evidence-based 
   nonpharmacologic options. This White Paper details the historical context and 
   magnitude of the current pain problem including individual, social and economic 
   impacts as well as the challenges of pain management for patients and a 
   healthcare workforce engaging prevalent strategies not entirely based in current 
   evidence. Detailed here is the evidence-base for nonpharmacologic therapies 
   effective in postsurgical pain with opioid sparing, acute non-surgical pain, 
   cancer pain and chronic pain. Therapies reviewed include acupuncture therapy, 
   massage therapy, osteopathic and chiropractic manipulation, meditative movement 
   therapies Tai chi and yoga, mind body behavioral interventions, dietary 
   components and self-care/self-efficacy strategies. Transforming the system of 
   pain care to a responsive comprehensive model necessitates that options for 
   treatment and collaborative care must be evidence-based and include effective 
   nonpharmacologic strategies that have the advantage of reduced risks of adverse 
   events and addiction liability. The evidence demands a call to action to increase 
   awareness of effective nonpharmacologic treatments for pain, to train healthcare 
   practitioners and administrators in the evidence base of effective 
   nonpharmacologic practice, to advocate for policy initiatives that remedy system 
   and reimbursement barriers to evidence-informed comprehensive pain care, and to 
   promote ongoing research and dissemination of the role of effective 
   nonpharmacologic treatments in pain, focused on the short- and long-term 
   therapeutic and economic impact of comprehensive care practices.
C1 Departments of Family Medicine, Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA. 
   Department of Family Medicine & Community Health, Icahn School of Medicine at Mount Sinai, New York, NY. 
   Department of Medicine, University of California School of Medicine, San Francisco, CA.
   Department of Pain Management, Scripps Center for Integrative Medicine, La Jolla, CA.
   Oregon Collaborative for Integrative Medicine, Portland, OR.
   Departments of Psychiatry and Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA.
   MedStar Health, Institute for Innovation, Integrative Medicine Initiatives, MedStar Montgomery Medical Center, Washington, DC.
   Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI.
   Osher Center for Integrative Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
   Beaumont Hospital Integrative Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI.
EM Arya.Nielsen@mountsinai.org
NR 0
TC 0
SN 1878-754
EI 
J9 Explore (NY)
PD MAY 8
PY 2018
VL 14
IS 3
BP 177
EP 211
DI 10.1016/j.explore.2018.02.001 
PG 34
WC Acupuncture Therapy; Acute Pain; therapy; Analgesics, Opioid; Cancer Pain; therapy; Chronic Pain; therapy; Diet; Humans; Mind-Body Therapies; Musculoskeletal Manipulations; Pain; etiology; Pain Management; methods; Pain, Postoperative; therapy; Physical Therapy Modalities; Treatment Outcome
UT PubMed:29735382
PM 29735382
DA 2018-05-08
ER

PT J
AU Feng, W
   Du, X
   Zhao, Y
AF Feng, Wei
   Du, Xixi
   Zhao, Yuxin
TI Enhancing treatment of lumbar disc herniation with Erxian decoction and auricular 
SO Medicine
LA English
DT Journal Article
AB OBJECTIVE: The incidence of lumbar disc herniation (LDH) is on the rise annually, 
   with an emerging trend of affecting younger age groups. This study aims to 
   investigate the clinical effectiveness of combining Erxian decoction with 
   auricular acupoint pressure therapy in treating LDH. Our objective is to furnish 
   evidence supporting the incorporation of traditional Chinese medicine (TCM) 
   rehabilitation techniques in clinical settings. METHODS: This randomized 
   controlled trial enrolled 102 patients diagnosed with LDH and allocated them into 
   Control and Intervention groups. The Control group underwent a 2-week 
   rehabilitation regimen, whereas the Intervention group received an augmented 
   treatment comprising Erxian decoction along with auricular acupoint pressure 
   therapy based on the Control group. Main outcome measures included 3 scales - 
   visual analog scale (VAS), Japanese Orthopedic Association (JOA), and Oswestry 
   Disability Index - as well as 3 inflammatory markers: C-reactive protein (CRP), 
   interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Additionally, pressure 
   pain threshold and pain tolerance threshold values were evaluated. Participants 
   were assessed at baseline, on 14-day, and on 28-day posttreatment. RESULTS: After 
   2 weeks of treatment, both the Control and Intervention groups exhibited 
   significant improvements in the VAS, JOA, ODI, CRP, IL-6, TNF-α, pressure pain 
   threshold, and pain tolerance threshold (P < .05). These improvements persisted 
   at the 28-day in the VAS, JOA, and ODI scores (P < .05). On 14-day, the 
   Intervention group showed significantly better outcomes compared to the Control 
   group in terms of the VAS, JOA, ODI, CRP, TNF-α, and pressure pain threshold 
   (P < .05). CONCLUSION: Compared to conventional rehabilitation therapy, the 
   combination of Erxian decoction and auricular acupoint pressure therapy 
   demonstrates clear benefits in alleviating symptoms in patients with LDH. This 
   approach offers fresh perspectives and substantiates evidence for future 
   treatment strategies in managing LDH.
C1 Department of Rehabilitation, Shangqiu Hospital of Traditional Chinese Medicine, Shangqiu, China.
   Department of Rehabilitation, Shangqiu Hospital of Traditional Chinese Medicine, Shangqiu, China.
   Department of Rehabilitation, Shangqiu Hospital of Traditional Chinese Medicine, Shangqiu, China.
   Department of Orthopedics, Shangqiu Hospital of Traditional Chinese Medicine, 
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JUL 12
PY 2024
VL 103
IS 28
BP e38899
EP e38899
DI 10.1097/MD.0000000000038899 
PG 1
WC Humans; Intervertebral Disc Displacement; therapy; Male; Female; Drugs, Chinese Herbal; therapeutic use; Middle Aged; Adult; Acupuncture Points; Lumbar Vertebrae; Pain Measurement; Treatment Outcome; Combined Modality Therapy; Interleukin-6; blood; Pain Threshold; drug effects; Acupressure; methods; Tumor Necrosis Factor-alpha; blood
UT PubMed:38996119
PM 38996119
DA 2024-07-12
ER

PT J
AU Kuai, L
   Chen, H
   Zhang, TT
   Yang, HY
AF Kuai, Le
   Chen, Hao
   Zhang, Ting-Ting
   Yang, Hua-Yuan
TI [Study on dose-effect relationship of electroacupuncture with different current 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB OBJECTIVE: To observe the dose-effect relationship of electroacupuncture of 
   different current intensities combined with Morphine of different dosage on 
   alleviating the rats' tibial cancer pain, and explore the possible mechanism, 
   which could provide the experiment basis for alleviating the tibial cancer pain 
   by electroacupuncture combined with Morphine. METHODS: One hundred female Wistar 
   rats were randomly divided into a normal group, a model group and eight treatment 
   groups, 10 cases in each group. The rats in the treatment groups were treated by 
   combined therapies of electroacupuncture of different intensities with 2 Hz /100 
   Hz dense-disperse wave on "Jiaji"(EX-B 2)and different dosage Morphine in 2 
   factor 3 level conditions, once a day for 6 days. The pain thresholds were 
   observed before the treatment and 0 min, 1 h, 2 h and 5 h after the first 
   treatment as well as after 3 and 6 times of treatments. The glial fibrillary 
   acidic protein (GFAP) expression was determined by immunohistochemical method. 
   RESULTS: The rats' pain thresholds were significantly increased with 
   electroacupuncture of 2 mA and 1 mA (all P < 0.01) on the 0 min, 1 h and 2 h of 
   the first treatment, between which there were no significant differences (all P > 
   0.05). The pain threshold was still increased by electroacupuncture of 2 mA on 
   the 5 h of the treatment (P < 0.01), while that of 1 mA failed to take effect (P 
   > 0.05). After 3 and 6 times of treatments, both electroacupuncture of 2 mA and 1 
   mA had the effect of increasing the pain threshold (all P < 0.01), and the effect 
   of 2 mA was superior to that of 1 mA (P < 0.05), had the synergistic effect with 
   5 mg/(kg x d) Morphine (P < 0.05). After 6 times of treatments, both 
   electroacupuncture of 2 mA and 1 mA could inhibit the expression of GFAP (both P 
   < 0.01), and there was no significant difference between them (P > 0.05). Both of 
   5 mg/(kg x d) and 2.5 mg/(kg x d) of Morphine, however, didn't bring about 
   inhibition effect (P > 0.05). CONCLUSION: There is a does-effect relationship on 
   electroacupuncture of different current intensity for alleviating the tibial 
   cancer pain in rats. The electroacupuncture with 2 mA, which is better than that 
   with 1 mA, has the synergistic effect with 5 mg/(kg x d) of Morphine. The 
   electroacupuncture can inhibit the expression of GFAP to cooperate with Morphine 
   for the purpose of alleviating the rats' tibial cancer pain.
C1 College of Acupuncture-Moxibustion and Massage, Shanghai University of TCM, Shanghai 201203, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUN 28
PY 2012
VL 32
IS 4
BP 331
EP 7
DI 
PG -324
WC Animals; Bone Neoplasms; complications; Electroacupuncture; instrumentation; Female; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; genetics; Humans; Pain; etiology; Pain Management; instrumentation; Rats; Rats, Wistar; Spine; metabolism; Tibia; metabolism
UT PubMed:22734384
PM 22734384
DA 2012-06-28
ER

PT J
AU Tian, W
   Zhang, Y
   Yu, B
   Jin, H
   Wang, W
   Yuan, T
   Yu, S
   Lu, H
AF Tian, Wei
   Zhang, Yun
   Yu, Bingjie
   Jin, Haiyan
   Wang, Wen
   Yuan, Ting
   Yu, Shulin
   Lu, Haiyan
TI Transcutaneous electrical acupoint stimulation for alleviating pain in patients 
SO Journal of cancer research and therapeutics
LA English
DT Journal Article
AB INTRODUCTION: Pancreatic ductal adenocarcinoma is the fourth leading cause of 
   cancer-related deaths globally, with a five-year survival rate of only 5%. 
   OBJECTIVES: Pancreatic ductal adenocarcinoma is often fatal because of the lack 
   of specific early symptoms and effective early screening tools. Therefore, 
   80%-85% of patients are usually diagnosed in the advanced stages. This study 
   aimed to investigate the analgesic effect of transcutaneous electrical acupoint 
   stimulation in patients with advanced pancreatic cancer. METHODS: Eighty patients 
   with advanced pancreatic cancer were recruited from the Integrative Medicine 
   Department of our hospital between June 2017 and October 2018 and randomly 
   divided into the experimental group ( n = 40) and the control group ( n = 40). 
   The experimental group received transcutaneous electrical acupoint stimulation 
   combined with analgesic medication for 3 consecutive days, while the control 
   group received only analgesic medication. The pain scores of the two groups 
   before and after intervention were compared. RESULTS: The mean pain severity 
   score was significantly lower in the experimental group than in the control group 
   on day 1 ( P < 0.001), day 2 ( P < 0.001), day 3 ( P = 0.005), and day 4 ( P = 
   0.043). CONCLUSION: Transcutaneous electrical acupoint stimulation therapy 
   effectively alleviates the pain of patients with advanced pancreatic cancer with 
   a high degree of safety and minimal adverse effects, and is worthy of clinical 
   application.
C1 Department of Nursing Administration, Fudan University Shanghai Cancer Center, Shanghai, China.
   Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
   Department of Nursing Administration, Fudan University Shanghai Cancer Center, Shanghai, China.
   Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
   Department of Apheresis Platelet, Jinan Blood Supply and Security Center, Shandong, China.
   Department of Nursing Administration, Fudan University Shanghai Cancer Center, Shanghai, China.
   Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
   Department of Nursing Administration, Fudan University Shanghai Cancer Center, Shanghai, China.
   Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
   Department of Nursing Administration, Fudan University Shanghai Cancer Center, Shanghai, China.
   Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
   Department of Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
   Department of Nursing Administration, Fudan University Shanghai Cancer Center, Shanghai, China.
   Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
NR 0
TC 0
SN 1998-413
EI 
J9 J Cancer Res Ther
PD JUN 27
PY 2024
VL 20
IS 4
BP 1334
EP 1337
DI 10.4103/jcrt.jcrt_2172_23 
PG 3
WC Humans; Female; Male; Pancreatic Neoplasms; complications; Middle Aged; Transcutaneous Electric Nerve Stimulation; methods; Acupuncture Points; Pain Management; methods; Aged; Cancer Pain; therapy; Pain Measurement; Treatment Outcome; Carcinoma, Pancreatic Ductal; therapy; Combined Modality Therapy
UT PubMed:38935575
PM 38935575
DA 2024-06-27
ER

PT J
AU Yeh, ML
   Hsu, CC
   Lin, M
   Lin, CJ
   Lin, JG
AF Yeh, Mei-Ling
   Hsu, Chin-Che
   Lin, Matthew
   Lin, Chuan-Ju
   Lin, Jaung-Geng
TI Effects of acupuncture-related intervention on chemotherapy-induced peripheral 
SO Complementary therapies in medicine
LA English
DT Journal Article
DE Acupuncture; Chemotherapy-induced peripheral neuropathy (CIPN); Pain; Quality of life; Umbrella review
AB BACKGROUND: Numerous studies have explored the role of acupuncture-related 
   treatments in alleviating chemotherapy-induced peripheral neuropathy (CIPN) and 
   improving the quality of life for patients with cancer, resulting in mixed 
   findings. This umbrella review aimed to synthesize existing systematic reviews 
   (SRs) to deliver an updated assessment of the certainty of evidence concerning 
   the effects of acupuncture-related treatments on CIPN and quality of life among a 
   diverse group of patients with cancer. METHODS: This umbrella review considered 
   eligible SRs published on one of nine electronic databases between inception and 
   August 2024. It included adult patients with cancer of any stage who were 
   undergoing chemotherapy. Interventions encompassed acupuncture, either alone or 
   with electrical stimulation or moxibustion, and transcutaneous electrical 
   acupoint/nerve stimulation (TEAS). The outcomes analyzed were changes in CIPN, 
   nerve conduction velocity (NCV), and quality of life. RESULTS: The outcomes were 
   evaluated using data obtained from 14 SRs that demonstrated moderate to high 
   methodological and reporting quality. The findings showed that acupuncture 
   (either alone or combined with electrical stimulation) and TEAS effectively 
   alleviated CIPN symptoms, reduced CIPN pain, improved NCV, and enhanced quality 
   of life. CONCLUSION: The findings of this umbrella review indicate that these 
   benefits were usually noticeable by the second week of treatment, persisted until 
   the sixth week, and then gradually declined. Sensory nerve recovery occurred more 
   rapidly than motor nerve recovery, often within 1.5 weeks. Although acupuncture 
   combined with moxibustion or acupressure also enhanced patient outcomes, there 
   was insufficient information available for further study analysis.
C1 School of Nursing, National Taipei University of Nursing & Health Sciences, Taipei Medical University Research Center of Cochrane Taiwan, 365 Minte Road,Taipei, Taiwan
   Taipei Medical University Research Center of Cochrane Taiwan.
   Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung, Taiwan.
   School of Nursing, National Taipei University of Nursing & Health Sciences, 365 Minte Road, Taipei, Taiwan.
   Hsinchu Cathay General Hospital, No. 678, Section 2, Zhonghua Road, Hsinchu, Taiwan
   National Taipei University of Nursing and Health Sciences. Electronicaddress: cgh306214@cgh.org.tw.
   School of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung, Taiwan. 
EM jglin@mail.cmu.edu.tw
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD FEB 4
PY 2025
VL 89
IS 
BP 103131
EP 103131
DI 10.1016/j.ctim.2025.103131 
PG 0
WC Humans; Quality of Life; Acupuncture Therapy; methods; Peripheral Nervous System Diseases; therapy; Antineoplastic Agents; adverse effects; Neoplasms; drug therapy; Transcutaneous Electric Nerve Stimulation; Adult
UT PubMed:39900253
PM 39900253
DA 2025-02-04
ER

PT J
AU Wang, J
   Zhang, Q
   Deng, Y
   Deng, G
   Huang, F
   Zhou, Y
   Jia, M
   Yi, H
AF Wang, Jinlong
   Zhang, Quanhui
   Deng, Yongwen
   Deng, Gen
   Huang, Feihong
   Zhou, Yiduo
   Jia, Mingyan
   Yi, Haoran
TI Efficacy and safety of heat-sensitive moxibustion in the treatment of ulcerative 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Ulcerative colitis (UC) is a chronic nonspecific intestinal 
   inflammatory disease with unclear etiology occurring in the colonic mucosa. Its 
   clinical manifestations are characterized by recurrent abdominal pain, diarrhea, 
   mucous pus, and blood stool. The severity of the disease varies, and itis 
   characterized by a high recurrence rate. Because of its long course of disease, 
   easy to relapse, protracted and difficult to recover, seriously affect the 
   quality of life, increase the economic burden of patients and society, and even 
   the risk of developing cancer, it has become one of the hot issues of general 
   concern in the medical field. Heat-sensitive moxibustion therapy has shown strong 
   advantages in the treatment of UC, and the curative effect is accurate. 
   therefore, this paper will carry out a systematic evaluation and meta analysis of 
   the efficacy and safety of heat-sensitive moxibustion in the treatment of UC. 
   METHODS: We will be searching 8 electronic databases, including PubMed, Embase, 
   Web of Science, Cochrane Library, the China National Knowledge Infrastructure, 
   Chinese Science and Technology Periodical Database, Wanfang Database, and Chinese 
   Biomedical Literature Database. We will search above electronic databases from 
   the beginning to December 2020, without any language restriction. Clinical 
   efficacy, including total effective rate or cure rate, clinical symptom integral 
   (abdominal pain, diarrhea, purulent stool), and recurrence rate will be accepted 
   as the primary outcomes. The changes of cytokine Hs-CRP, IL-6, TNF-αlevels in 
   serum, and improvement of colorectal mucosa will be used as secondary outcomes. 
   RevMan 5.3 software will be used for statistical analysis. The result about the 
   curative effect and safety of heat-sensitive moxibustion for UC will be presented 
   as risk ratio for dichotomous data and mean differences with a 95% confidence 
   interval for continuous data. RESULTS: When this research program is completed, 
   the relevant results can be obtained. CONCLUSIONS: The results of this study will 
   provide reliable evidence for the efficacy and safety of heat-sensitive 
   moxibustion in the treatment of UC. INPLASY REGISTRATION NUMBER: 
   INPLASY20201101034.
C1 College of clinical medicine, Jiangxi University of Traditional Chinese Medicine.
   Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
   College of clinical medicine, Jiangxi University of Traditional Chinese Medicine.
   College of clinical medicine, Jiangxi University of Traditional Chinese Medicine.
   College of clinical medicine, Jiangxi University of Traditional Chinese Medicine.
   College of clinical medicine, Jiangxi University of Traditional Chinese Medicine.
   College of clinical medicine, Jiangxi University of Traditional Chinese Medicine.
   College of clinical medicine, Jiangxi University of Traditional Chinese Medicine.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD FEB 4
PY 2021
VL 100
IS 4
BP e24078
EP e24078
DI 10.1097/MD.0000000000024078 
PG 1
WC Colitis, Ulcerative; therapy; Cytokines; metabolism; Humans; Intestinal Mucosa; metabolism; Moxibustion; adverse effects; Quality of Life; Randomized Controlled Trials as Topic; Recurrence; Research Design; Severity of Illness Index; Temperature; Meta-Analysis as Topic; Systematic Reviews as Topic
UT PubMed:33530201
PM 33530201
DA 2021-02-04
ER

PT J
AU Hadoush, H
   Almhasis, R
   Kassab, M
   Almasri, NA
   Al-Wardat, M
AF Hadoush, Hikmat
   Almhasis, Reem
   Kassab, Manal
   Almasri, Nihad A
   Al-Wardat, Mohammad
TI Effectiveness of Non-pharmacological interventions on pain and fatigue management 
SO Journal of bodywork and movement therapies
LA English
DT Journal Article
DE Cancer; Fatigue; Non-pharmacological; Rehabilitation; pain
AB Pain and fatigue are the primary symptoms that cancer survivors frequently 
   report. The goal of this meta-analysis was to evaluate how effective 
   non-pharmacological interventions are in managing pain and fatigue in cancer 
   survivors. Approach: This research consisted solely of randomized controlled 
   trials (RCTs) that enlisted participants aged 18-80 years who had been diagnosed 
   with any form of cancer. The risk of bias was evaluated through the Cochrane risk 
   of bias tool. The process of meta-analyses involved calculating the standardized 
   mean difference (SMD) within a 95 % confidence interval (CI) using Review Manager 
   software. Outcome: Five studies involving 283 participants in the treatment group 
   demonstrated a noteworthy benefit of acupuncture and reflexology in pain relief 
   (SMD -0.69, 95 % CI -1.29 to -0.10, Z = 2.28, p = 0.02, and I(2) = 82 %). 
   Nonetheless, five studies with 370 participants (221 in the intervention group) 
   found a minor impact on pain control from engaging in physical activity (SMD 
   -0.29, 95 % CI -0.74 to 0.16, Z = 1.27, p = 0.20, I(2) = 76 %). Regarding fatigue 
   management, four studies involving 368 participants (intervention group = 221) 
   found a minor impact of physical activity on fatigue management (SMD - 0.06, 95 % 
   CI - 0.46 to 0.33, Z = 0.30, p = 0.76, I2 = 72 %). In conclusion, data that was 
   pooled and analyzed found that non-pharmacological interventions were found to 
   have a positive therapeutic impact on pain management among cancer survivors. 
   However, the same interventions showed little to no therapeutic effect on 
   fatigue. Therefore, it is strongly recommended to conduct more high-quality 
   studies.
C1 Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan. 
   Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
   Department of Maternal and Child Health, Faculty of Nursing, Jordan University of Science and Technology, Irbid, Jordan.
   Department of Rehabilitation Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
   Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
EM mhadoush@just.edu.jo
NR 0
TC 0
SN 1532-928
EI 
J9 J Bodyw Mov Ther
PD SEP 16
PY 2025
VL 44
IS 
BP 251
EP 260
DI 10.1016/j.jbmt.2025.05.046 
PG 9
WC Humans; Acupuncture Therapy; methods; Cancer Survivors; Exercise; Fatigue; therapy; Massage; methods; Neoplasms; complications; Pain Management; methods; Randomized Controlled Trials as Topic
UT PubMed:40954588
PM 40954588
DA 2025-09-16
ER

PT J
AU Aderibigbe, O
   Groft-MacFarlane, C
   Chu, EY
AF Aderibigbe, Oyinade
   Groft-MacFarlane, Caroline
   Chu, Emily Y
TI A Blue-Gray Macule on the Back: Answer.
SO The American Journal of dermatopathology
LA English
DT Review
C1 Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA
   and.
   Dermatology Associates of Bryn Mawr Medical Specialists, Bryn Mawr, PA.
   Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA
   and.
NR 0
TC 0
SN 1533-031
EI 
J9 Am J Dermatopathol
PD DEC 28
PY 2019
VL 42
IS 1
BP 65
EP 65
DI 10.1097/DAD.0000000000001267 
PG 0
WC Acupuncture Therapy; methods; Biopsy, Needle; Diagnosis, Differential; Humans; Immunohistochemistry; Low Back Pain; diagnosis; Male; Middle Aged; Nevus, Blue; diagnosis; Ochronosis; diagnosis; Pigmentation Disorders; diagnosis; Rare Diseases
UT PubMed:31880637
PM 31880637
DA 2019-12-28
ER

PT J
AU Zhou, M
   Yang, S
   Chen, R
   Zhao, J
   Dai, Y
   Xu, J
   Zhu, G
AF Zhou, Mei
   Yang, Shuo
   Chen, Rixin
   Zhao, Jing
   Dai, Youming
   Xu, Jing
   Zhu, Guoqing
TI [Heat-sensitive moxibustion combined with tropisetron hydrochloride for 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE chemotherapy-induced nausea and vomiting; heat-sensitive moxibustion; quality of life; randomized controlled trial (RCT); tropisetron hydrochloride
AB OBJECTIVE: To compare the clinical efficacy of heat-sensitive moxibustion 
   combined with tropisetron hydrochloride and tropisetron hydrochloride alone in 
   the treatment of chemotherapy-induced nausea and vomiting (CINV). METHODS: Sixty 
   CINV patients were randomly divided into an observation group and a control 
   group, 30 cases in each group.The control group was treated with tropisetron 
   hydrochloride. On the basis of the treatment in the control group, heat-sensitive 
   acupoints were explored at Zhongwan (CV 12), Shenque (CV 8), Qihai (CV 6), 
   Guanyuan (CV 4), Shangwan (CV 13), Xiawan (CV 10), Jianli (CV 11) and bilateral 
   Zusanli (ST 36), Neiguan (PC 6), Tianshu (ST 25), Liangmen (ST 21) areas in the 
   observation group，and heat-sensitive moxibustion was applied at heat-sensitive 
   acupoints. The treatment started from the day of chemotherapy in both groups, 
   once a day for 7 days. The occurrence and severity of nausea and vomiting after 
   chemotherapy were recorded after each treatment on the 1st to 7th days of 
   chemotherapy in the two groups, the complete remission rate was evaluated. The 
   KPS score, quality of life scale score before and after treatment and incidence 
   of myelosuppression were compared between the two groups. RESULTS: On the 2nd to 
   4th days of chemotherapy, the incidence and severity of nausea and vomiting in 
   the observation group were lower than those in the control group (P<0.05), the 
   complete remission rates of nausea and vomiting were higher than those in the 
   control group (P<0.05). After treatment, the KPS score in the observation group 
   was higher than those before treatment and in the control group (P<0.05). After 
   treatment, the scores of emotional function and overall health status in the 
   observation group were higher than those before treatment and in the control 
   group (P<0.05), the scores of fatigue, pain, insomnia, loss of appetite and 
   diarrhea were lower than those before treatment and in the control group 
   (P<0.05). The incidence of myelosuppression in the observation group was 20.0% 
   (6/30), which was lower than 46.7% (14/30) in the control group (P<0.05). 
   CONCLUSION: Heat-sensitive moxibustion combined with tropisetron hydrochloride 
   can effectively reduce nausea and vomiting after chemotherapy in patients with 
   malignant tumor, improve the quality of life, relieve the myelosuppression caused 
   by chemotherapy drugs.
C1 Department of Acupuncture-Moxibustion and Rehabilitation, Second Affiliated Hospital of Guizhou University of TCM, Guiyang 550003, China.
   Department of Acupuncture-Moxibustion and Rehabilitation, Second Affiliated Hospital of Guizhou University of TCM, Guiyang 550003, China.
   Department of Acupuncture and Moxibustion, Affiliated Hospital of Jiangxi University of CM.
   College of Acupuncture-Moxibustion and Tuina, Guizhou University of TCM.
   College of Acupuncture-Moxibustion and Tuina, Guizhou University of TCM.
   Department of Acupuncture-Moxibustion and Rehabilitation, Second Affiliated Hospital of Guizhou University of TCM, Guiyang 550003, China.
   Department of Acupuncture-Moxibustion and Rehabilitation, Second Affiliated Hospital of Guizhou University of TCM, Guiyang 550003, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAY 20
PY 2024
VL 44
IS 5
BP 531
EP 6
DI 10.13703/j.0255-2930.20230705-0001 
PG -525
WC Humans; Moxibustion; Vomiting; therapy; Male; Middle Aged; Female; Tropisetron; Nausea; therapy; Adult; Acupuncture Points; Aged; Antineoplastic Agents; adverse effects; Combined Modality Therapy; Indoles; adverse effects; Neoplasms; drug therapy; Young Adult; Treatment Outcome
UT PubMed:38764103
PM 38764103
DA 2024-05-20
ER

PT J
AU Henry, NL
   Kidwell, KM
   Kozar, S
   Snyder, S
   Zick, SM
AF Henry, N Lynn
   Kidwell, Kelley M
   Kozar, Stephanie
   Snyder, Sara
   Zick, Suzanna M
TI Self-acupressure for patients with breast cancer experiencing aromatase 
SO PloS one
LA English
DT Journal Article
AB BACKGROUND: Aromatase inhibitors (AI) reduce hormone receptor-positive breast 
   cancer recurrence risk by about 50%. However, half of AI-treated postmenopausal 
   women report new or worsened musculoskeletal symptoms (AIMSS), and 20% 
   discontinue therapy prematurely. Acupuncture is effective for reducing symptoms, 
   but many women are not able to access acupuncture therapy. We hypothesize that 
   self-administered acupressure will reduce AIMSS. MATERIALS AND METHODS: 
   Postmenopausal women who have been receiving treatment with an AI for more than 3 
   weeks but less than 2 years, and who report new or worsened joint pain or 
   myalgias since starting AI therapy with worst pain of at least 4 out of 10 on a 
   numerical rating scale, are eligible. Fifty participants will be enrolled and 
   randomized 1:1 to treatment with true or sham acupressure for 12 weeks. 
   Participants will self-apply pressure for 3 minutes to each of the 9 acupoints 
   daily. All participants will complete a pain assessment weekly, and a battery of 
   symptom questionnaires every 6 weeks. Optional stool samples will be collected 
   after 0 and 12 weeks of acupressure to examine changes in the gut microbiome. The 
   primary endpoint is change in worst pain on the Brief Pain Inventory-Short Form 
   with 12 weeks of the acupressure intervention, evaluated with generalized 
   estimating equations. CONCLUSION: Determination that self-administered 
   acupressure reduces AIMSS in this randomized phase 2 pilot trial will lead to a 
   larger randomized phase 3 clinical trial to confirm the efficacy of 
   self-acupressure. Reduction of AI-related arthralgias may improve persistence 
   with breast cancer therapy, breast cancer outcomes, and quality of life for 
   AI-treated patients. TRIAL REGISTRATION: Clinicaltrials.gov NCT06228768.
C1 University of Michigan Medical School, Ann Arbor, MI, United States of America.
   University of Michigan School of Public Health, Ann Arbor, MI, United States of America.
   University of Michigan Medical School, Ann Arbor, MI, United States of America.
   University of Michigan Medical School, Ann Arbor, MI, United States of America.
   University of Michigan Medical School, Ann Arbor, MI, United States of America.
   University of Michigan School of Public Health, Ann Arbor, MI, United States of 
NR 0
TC 0
SN 1932-620
EI 
J9 PLoS One
PD JAN 22
PY 2025
VL 20
IS 1
BP e0311044
EP e0311044
DI 10.1371/journal.pone.0311044 
PG 1
WC Aged; Female; Humans; Middle Aged; Acupressure; methods; Aromatase Inhibitors; adverse effects; Arthralgia; therapy; Breast Neoplasms; drug therapy; Pilot Projects; Postmenopause; Randomized Controlled Trials as Topic
UT PubMed:39841658
PM 39841658
DA 2025-01-22
ER

PT J
AU Tao, S
   Wang, X
   Liao, C
   Xiong, Y
   Tang, J
   Jiang, N
   Li, Y
   Hu, X
   Shuai, R
   Wang, Y
   Wu, P
AF Tao, Siyu
   Wang, Xue
   Liao, Chenxi
   Xiong, Yan
   Tang, Jie
   Jiang, Nannan
   Li, Yuan
   Hu, Xinyue
   Shuai, Rouxian
   Wang, Yueyue
   Wu, Ping
TI The Efficacy of Moxibustion on the Serum Levels of CXCL1 and β-EP in Patients 
SO Pain research & management
LA English
DT Journal Article
AB OBJECTIVE: This study aims to evaluate the efficacy of moxibustion on joint 
   swelling and pain and the levels of C-X-C motif chemokine ligand 1 (CXCL1), 
   β-endorphin (β-EP) in serum of rheumatoid arthritis (RA) patients and to 
   investigate the anti-inflammatory and analgesic mechanism of moxibustion on 
   improving RA. METHODS: Sixty-eight patients with RA were randomly and equally 
   classified into the control and treatment groups. The control group was treated 
   with routine drug therapy, while the treatment group received routine drug 
   therapy and moxibustion. Both groups were treated for eight weeks. The symptoms 
   and laboratory indicators of RA patients were compared in the two groups before 
   and after intervention. RESULTS: Sixty-one patients completed the study: four 
   patients dropped out from the treatment group and three from the control group. 
   Trial endpoints were change (∆) in symptoms, measured by Ritchie's articular 
   index (RAI), swollen joint count (SJC), and laboratory indicators, measured by 
   the level of CXCL1, β-EP, tumor necrosis factor-a (TNF-α), and interleukin-1β 
   (IL-1β). ∆RAI, ∆SJC, ∆CXCL1, ∆β-EP, ∆TNF-α, and ∆IL-1β in the treatment group 
   were superior to the control group (13.50 [14.50] versus 6.00 [13.00] in ∆RAI, 
   4.00 [3.00] versus 2.00 [4.00] in ∆SJC, 0.04 ± 0.79 ng/mL versus 
   -0.01 ± 0.86 ng/mL in ∆CXCL1, -2.43 [5.52] pg/mg versus -0.04 [4.09] pg/mg in 
   ∆β-EP, 3.45 [5.90] pg/mL versus 1.55 [8.29] pg/mL in ∆TNF-α, and 6.15 ± 8.65 
   pg/mL versus 1.28 ± 8.51 pg/mL in ∆IL-1β; all P < 0.05). CONCLUSION: Moxibustion 
   can improve the joint swelling and pain symptoms in patients with RA, which may 
   be related to the fact that moxibustion can reduce the release of inflammatory 
   factors in patients with RA and downregulate the level of CXCL1 and increase the 
   level of β-EP at the same time. This trial is registered with 
   ChiCTR-IOR-17012282.
C1 Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
   West China Fourth Hospital, Chengdu 610075, Sichuan Province, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
   Chengdu University of Traditional Chinese Medicine Affiliated Hospital, Chengdu 610075, Sichuan Province, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
   Sichuan Integrative Medicine Hospital, Chengdu 610075, Sichuan Province, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
NR 0
TC 0
SN 1918-152
EI 1203-676
J9 Pain Res Manag
PD OCT 26
PY 2021
VL 2021
IS 
BP 7466313
EP 7466313
DI 10.1155/2021/7466313 
PG 0
WC Anti-Inflammatory Agents; Arthritis, Rheumatoid; therapy; Chemokine CXCL1; Humans; Moxibustion; Tumor Necrosis Factor-alpha; beta-Endorphin
UT PubMed:34691317
PM 34691317
DA 2021-10-26
ER

PT J
AU Sand-Jecklin, K
   Reiser, V
AF Sand-Jecklin, Kari
   Reiser, Victoria
TI Use of Seva Stress Release Acupressure to Reduce Pain, Stress, and Fatigue in 
SO Journal of hospice and palliative nursing : JHPN : the official journal of the 
LA English
DT Journal Article
AB Patients undergoing treatment for cancer often experience stress, fatigue, and 
   pain during their treatment. Medical management of these symptoms can cause 
   additional adverse effects, but it is possible that noninvasive complementary 
   therapies may be able to reduce these symptoms without unwanted adverse effects. 
   The purpose of this study was to assess the feasibility and impact of the Seva 
   Stress Release acupressure protocol on stress, fatigue, pain, and vital signs of 
   patients hospitalized for cancer treatment. Thirty patients receiving cancer 
   treatment and experiencing stress, fatigue, and pain were recruited for the 
   study. After obtaining informed consent, baseline data (survey and vital signs) 
   were obtained, followed by administration of the Seva Stress Release. After the 
   intervention, vital signs were obtained, and patients completed 2 additional 
   surveys. After Seva, patient stress, fatigue, pain, heart rate, and respirations 
   were significantly decreased (P = .000). Sixty-six percent of participants 
   experienced symptom relief for at least 1 to 4 hours. Qualitative findings also 
   indicated that patients reported better sleep and mental clarity after the 
   intervention. The Seva protocol could be taught to nurses and be used as an 
   independent intervention for patients experiencing adverse effects of cancer 
   treatment, to promote comfort and reduce stress and fatigue.
C1 Kari Sand-Jecklin, EdD, MSN, RN, AHN-BC, is associate professor, West Virginia University School of Nursing, Morgantown. Victoria Reiser, BSN, RN, is DNPstudent, University of Pittsburgh School of Nursing, Pennsylvania.
NR 0
TC 0
SN 1539-070
EI 
J9 J Hosp Palliat Nurs
PD NOV 1
PY 2018
VL 20
IS 6
BP 521
EP 528
DI 10.1097/NJH.0000000000000484 
PG 7
WC Acupressure; methods; Adult; Aged; Aged, 80 and over; Fatigue; psychology; Female; Hospitalization; statistics & numerical data; Humans; Male; Middle Aged; Neoplasms; complications; Pain; complications; Pain Management; methods; Pilot Projects; Stress, Psychological; psychology
UT PubMed:30379796
PM 30379796
DA 2018-11-01
ER

PT J
AU Mao, H
   Mao, JJ
   Chen, J
   Li, Q
   Chen, X
   Shen, X
   Zhao, L
   Wei, J
   Shen, X
AF Mao, Huijuan
   Mao, Jun J
   Chen, Junchao
   Li, Qing
   Chen, Xuefen
   Shen, Xubo
   Zhao, Ling
   Wei, Jianzi
   Shen, Xueyong
TI Effects of infrared laser moxibustion on cancer-related fatigue in breast cancer 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Cancer-related fatigue (CRF) is the most common and distressing 
   symptom associated with cancer treatment that breast cancer survivors (BCS) 
   experience. We previously found that laser moxibustion may be efficacious for 
   CRF. The primary aim of this study is to determine the specific efficacy of 
   10.6 μm infrared laser moxibustion on CRF. The secondary aim is to evaluate the 
   effect of infrared laser moxibustion on co-existing symptoms that BCS experience. 
   METHODS: We will conduct a randomized, sham-controlled, three-arm trial of 
   infrared laser moxibustion (ILM) against sham ILM (SILM) and waitlist control 
   (WLC) among BCS with moderate to severe fatigue. The two intervention groups will 
   receive either real or sham infrared laser moxibustion on four acupoints (i.e., 
   ST36 [bilateral], CV4, and CV6) for 20 minutes each session for 6 weeks (twice 
   per week). The primary endpoint is the change in fatigue score from Baseline to 
   Week 6 as measured by the Chinese version of the Brief Fatigue Inventory (BFI-C). 
   Our secondary aim is to compare the severity of co-morbidities (e.g., depression, 
   insomnia, and pain) among the 3 groups. DISCUSSION: The results of our trial will 
   establish evidence for the efficacy of infrared laser moxibustion for CRF, a very 
   common and challenging symptom. TRIAL REGISTRATION NUMBER: NCT03553355.
C1 Shanghai University of Traditional Chinese Medicine, School of Acupuncture-Moxibustion and Tuina, Shanghai, China.
   Memorial Sloan Kettering Cancer Center, Bendheim Integrative Medicine Center, New York, NY.
   Shanghai University of Traditional Chinese Medicine, Institute of Disciplinary Science.
   Memorial Sloan Kettering Cancer Center, Bendheim Integrative Medicine Center, New York, NY.
   Shanghai University of Traditional Chinese Medicine, School of Public Health.
   Shanghai University of Traditional Chinese Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine.
   Shanghai University of Traditional Chinese Medicine, School of Acupuncture-Moxibustion and Tuina, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, School of Acupuncture-Moxibustion and Tuina, Shanghai, China.
   Shanghai University of Traditional Chinese Medicine, School of Acupuncture-Moxibustion and Tuina, Shanghai, China.
   Shanghai Research Center of Acupuncture and Meridian, Shanghai, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD AUG 24
PY 2019
VL 98
IS 34
BP e16882
EP e16882
DI 10.1097/MD.0000000000016882 
PG 1
WC Breast Neoplasms; complications; Cancer Survivors; psychology; China; Fatigue; therapy; Female; Humans; Infrared Rays; therapeutic use; Moxibustion; methods; Quality of Life; Randomized Controlled Trials as Topic
UT PubMed:31441863
PM 31441863
DA 2019-08-24
ER

PT J
AU Sun, L
   Ramalingam, MB
   Baser, R
   Santos, Teles M
   Seluzicki, C
   Li, QS
   Mao, JJ
AF Sun, Lingyun
   Ramalingam, Mothi Babu
   Baser, Raymond
   Santos Teles, Marco
   Seluzicki, Christina
   Li, Qing Susan
   Mao, Jun J
TI Acupuncture Improves Functional Limitations for Cancer Patients with Chronic 
SO Current oncology (Toronto, Ont.)
LA English
DT Journal Article
DE acupuncture; cancer pain; extremity function; randomized controlled trial; rehabilitation
AB Chronic pain significantly impairs functional performance in patients with 
   cancer. Although acupuncture is effective for cancer-related pain, its impact on 
   pain-related functional interference remains unclear. This secondary analysis of 
   the PEACE randomized clinical trial included patients with prior cancer diagnoses 
   and musculoskeletal pain for ≥3 months. Participants were randomized to groups 
   undergoing 10 weeks of electro-acupuncture, auricular acupuncture, or a waitlist 
   control. Functional performance was assessed using the Quick-Disability 
   Arm/Shoulder/Hand (Q-DASH) for upper limbs and the Western Ontario and McMaster 
   Universities Osteoarthritis (WOMAC) subscale for lower limbs (higher scores = 
   worse function). Linear mixed models compared changes over time between groups, 
   with week 12 as the primary endpoint. Functional changes were also compared 
   between pain responders and non-responders in the acupuncture arms. Among 360 
   patients (mean [SD] age, 62.1 [12.7] years; 69.7% women), mean baseline Q-DASH 
   and WOMAC scores were 33.2 (19.8) and 33.3 (20.3). At week 12, both 
   electro-acupuncture and auricular acupuncture significantly improved function 
   versus waitlist: Q-DASH by -7.18 and -9.64 points, respectively, and WOMAC by 
   -6.89 and -7.61 points (all p < 0.001). No differences were found between the two 
   acupuncture groups. Treatment effects on Q-DASH diminished during follow-up, 
   while improvements on WOMAC persisted. Within the acupuncture groups, pain 
   responders achieved greater functional gains than non-responders (Q-DASH, -6.74; 
   WOMAC, -6.16; both p < 0.001). Electro-acupuncture and auricular acupuncture 
   improved upper and lower extremity function in cancer patients with chronic pain. 
   These findings support acupuncture as a potential adjunct in functional 
   rehabilitation for cancer survivors.
C1 Oncology Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering 
   Department of Rehabilitation Medicine, Singapore General Hospital, Singapore 169856, Singapore.
   Epidemiology-Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 60637, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
NR 0
TC 0
SN 1718-772
EI 1198-005
J9 Curr Oncol
PD NOV 26
PY 2025
VL 32
IS 11
BP 
EP 
DI 10.3390/curroncol32110640 
PG 0
WC Humans; Female; Male; Middle Aged; Chronic Pain; therapy; Acupuncture Therapy; methods; Aged; Neoplasms; complications; Cancer Pain; therapy
UT PubMed:41294702
PM 41294702
DA 2025-11-26
ER

PT J
AU Tao, S
   Yang, Y
   Tang, J
   Wang, X
   Jiang, N
   Li, Y
   Wu, P
AF Tao, Siyu
   Yang, Yi
   Tang, Jie
   Wang, Xue
   Jiang, Nannan
   Li, Yuan
   Wu, Ping
TI The efficacy of moxibustion on the pressure pain threshold and substance P / 
SO Complementary therapies in medicine
LA English
DT Journal Article
DE ChiCTR-IOR-17012282; Interleukin-1β; Leukotriene B4; Moxibustion; Pressure pain threshold; Rheumatoid arthritis; Substance P; Trial registration number; Tumor necrosis factor-α
AB OBJECTIVE: To observe the effects of moxibustion on pressure-pain thresholds 
   (PPTs) in affected joints and non-joint areas, as well as the contents of 
   substance P (SP) and leukotriene B4 (LTB4) in serum of patients with rheumatoid 
   arthritis (RA), and to explore the analgesic mechanism of moxibustion in RA 
   patients. METHODS: A total of 72 patients with RA were randomly and equally 
   classified into the control and treatment groups. The control group was treated 
   with routine drug therapy, while the treatment group received routine drug 
   therapy and moxibustion. Both groups were treated for 8 weeks. The symptoms, 
   measured by PPTs, Visual analogue scale (VAS), pain joint count (PJC), swollen 
   joint count (SJC) and disease activity score of 28 joints (DAS28), and laboratory 
   indicators, measured by the level of SP, LTB4, tumor necrosis factor- α (TNF-α) 
   and interleukin-1β (IL-1β), were compared in the two groups before and after 
   intervention. RESULTS: A total of 66 patients completed the trial, with 1 
   patients dropping out from the treatment group and 5 patients being excluded and 
   dropped from the control group. Trial endpoints were change (∆) in symptoms and 
   laboratory indicators. The treatment group showed superior in ∆PPTs of the 
   interphalangeal joints(1301.71 (95 %CI, 967.43-1636.00) vs 443.23(95 %CI, 
   99.51-786.95)), ∆SP(10.11 (95 %CI, 5.85-14.37) vs 3.10 (95 %CI, -1.13-7.34)), ∆ 
   LTB4(13.17 (95 %CI, 7.81-18.54) vs 3.37 (95 %CI, -5.73-12.48)), ∆TNF-α(4.57 
   (95 %CI, 2.60-6.55) vs 0.68 (95 %CI, -1.03-2.40)), ∆IL-1β(4.63 (95 %CI, 
   2.59-6.66) vs 1.63 (95 %CI, -0.53-3.80)), ∆PJC(7.14 (95 %CI, 5.17-8.58) vs 1.84 
   (95 %CI, 0.66-3.02)), ∆SJC(5.20 (95 %CI, 3.44-6.96) vs 1.00(95 %CI, 0.02-1.98)), 
   ∆VAS(3.6 (95 %CI, 2.99-4.21) vs 0.9 (95 %CI, 0.24-1.57)), and ∆DAS(1.68 (95 %CI, 
   1.44-1.92) vs 0.41 (95 %CI, 0.08-0.73)) compared to the control group, at weeks 
   4. Furthermore, there was a significant negative correlation between ∆PPTs of the 
   interphalangeal joints and ∆SP in the treatment group (r < 0, P < 0.05). 
   CONCLUSION: Moxibustion combined with conventional western medicine can 
   significantly improve PPTs in affected joints of RA patients, alleviate clinical 
   symptoms, and reduce disease activity. The potential mechanism may be related to 
   the down-regulation of SP and LTB4 levels and the reduction of the release of 
   inflammatory factors Il-1β and TNF-α by moxibustion. The lack of double-blinding 
   is a limitation of our study, which we plan to avoid by establishing a sham 
   moxibustion group in the subsequent trials.
C1 Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province 610075, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province 610075, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province 610075, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province 610075, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province 610075, China.
   Chengdu University of Traditional Chinese Medicine Affiliated Hospital, Chengdu, Sichuan province 610075, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province 610075, China. 
EM wuping_33@163.com
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD MAY 29
PY 2025
VL 92
IS 
BP 103187
EP 103187
DI 10.1016/j.ctim.2025.103187 
PG 0
WC Humans; Moxibustion; methods; Female; Male; Arthritis, Rheumatoid; therapy; Middle Aged; Leukotriene B4; blood; Substance P; blood; Adult; Pain Threshold; physiology; Aged; Interleukin-1beta; blood; Pain Measurement
UT PubMed:40436210
PM 40436210
DA 2025-05-29
ER

PT J
AU Liou, KT
   Garland, SN
   Meghani, SH
   Kaye, NM
   Thompson, E
   Li, QS
   Mao, JJ
AF Liou, Kevin T
   Garland, Sheila N
   Meghani, Salimah H
   Kaye, Nadia M
   Thompson, Embree
   Li, Q Susan
   Mao, Jun J
TI Racial differences in treatment adherence and response to acupuncture and 
SO Cancer medicine
LA English
DT Journal Article
DE acupuncture; cancer survivorship; cognitive behavioral therapy; insomnia; oncology; racial disparities; sleep health
AB BACKGROUND: Racial disparities in sleep are well-documented. However, 
   evidence-based options for addressing these disparities are lacking in cancer 
   populations. To inform future research on sleep interventions, this study aims to 
   understand racial differences in treatment responses to acupuncture and cognitive 
   behavioral therapy for insomnia (CBT-I) among Black and White cancer survivors. 
   METHODS: We conducted a secondary analysis of a comparative effectiveness trial 
   evaluating acupuncture versus CBT-I for insomnia in cancer survivors. We compared 
   insomnia severity, sleep characteristics, and co-morbid symptoms, as well as 
   treatment attitudes, adherence, and responses among Black and White participants. 
   RESULTS: Among 156 cancer survivors (28% Black), Black survivors reported poorer 
   sleep quality, longer sleep onset latency, and higher pain at baseline, compared 
   to White survivors (all p < 0.05). Black survivors demonstrated lower adherence 
   to CBT-I than White survivors (61.5% vs. 88.5%, p = 0.006), but their treatment 
   response to CBT-I was similar to white survivors. Black survivors had similar 
   adherence to acupuncture as white survivors (82.3% vs. 93.4%, p = 0.16), but they 
   had greater reduction in insomnia severity with acupuncture (-3.0 points, 95% CI 
   -5.4 to 0.4, p = 0.02). CONCLUSION: This study identified racial differences in 
   sleep characteristics, as well as treatment adherence and responses to CBT-I and 
   acupuncture. To address racial disparities in sleep health, future research 
   should focus on improving CBT-I adherence and confirming the effectiveness of 
   acupuncture in Black cancer survivors.
C1 Department of Medicine, Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Psychology and Oncology, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
   Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
   Stuyvesant High School, New York, New York, USA.
   Weill Cornell Medical College, New York, New York, USA.
   Department of Medicine, Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Medicine, Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
NR 0
TC 0
SN 2045-763
EI 
J9 Cancer Med
PD AUG 20
PY 2024
VL 13
IS 16
BP e7344
EP e7344
DI 10.1002/cam4.7344 
PG 1
WC Adult; Aged; Female; Humans; Male; Middle Aged; Acupuncture Therapy; Black or African American; psychology; Cancer Survivors; psychology; Cognitive Behavioral Therapy; methods; Neoplasms; therapy; Sleep Initiation and Maintenance Disorders; therapy; Treatment Adherence and Compliance; statistics & numerical data; Treatment Outcome; White; psychology
UT PubMed:39161103
PM 39161103
DA 2024-08-20
ER

PT J
AU Mao, JJ
   Farrar, JT
   Bruner, D
   Zee, J
   Bowman, M
   Seluzicki, C
   DeMichele, A
   Xie, SX
AF Mao, Jun J
   Farrar, John T
   Bruner, Deborah
   Zee, Jarcy
   Bowman, Marjorie
   Seluzicki, Christina
   DeMichele, Angela
   Xie, Sharon X
TI Electroacupuncture for fatigue, sleep, and psychological distress in breast 
SO Cancer
LA English
DT Journal Article
DE acupuncture; aromatase inhibitors; breast neoplasm; fatigue; psychological distress; sleep
AB BACKGROUND: Although fatigue, sleep disturbance, depression, and anxiety are 
   associated with pain in breast cancer patients, it is unknown whether acupuncture 
   can decrease these comorbid symptoms in cancer patients with pain. The objective 
   of this study was to evaluate the effect of electroacupuncture (EA) on fatigue, 
   sleep, and psychological distress in breast cancer survivors who experience joint 
   pain related to aromatase inhibitors (AIs). METHODS: The authors performed a 
   randomized controlled trial of an 8-week course of EA compared with a waitlist 
   control (WLC) group and a sham acupuncture (SA) group in postmenopausal women 
   with breast cancer who self-reported joint pain attributable to AIs. Fatigue, 
   sleep disturbance, anxiety, and depression were measured using the Brief Fatigue 
   Inventory (BFI), the Pittsburgh Sleep Quality Index (PSQI), and the Hospital 
   Anxiety and Depression Scale (HADS). The effects of EA and SA versus WLC on these 
   outcomes were evaluated using mixed-effects models. RESULTS: Of the 67 randomly 
   assigned patients, baseline pain interference was associated with fatigue 
   (Pearson correlation coefficient [r]=0.75; P < .001), sleep disturbance (r=0.38; 
   P=.0026), and depression (r=0.58; P < .001). Compared with the WLC condition, EA 
   produced significant improvements in fatigue (P=.0095), anxiety (P=.044), and 
   depression (P=.015) and a nonsignificant improvement in sleep disturbance 
   (P=.058) during the 12-week intervention and follow-up period. In contrast, SA 
   did not produce significant reductions in fatigue or anxiety symptoms but did 
   produce a significant improvement in depression compared with the WLC condition 
   (P=.0088). CONCLUSIONS: Compared with usual care, EA produced significant 
   improvements in fatigue, anxiety, and depression; whereas SA improved only 
   depression in women experiencing AI-related arthralgia.
C1 Abramson Cancer Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
   Department of Biostatistics and Epidemiology, Center for ClinicalEpidemiology and Biostatistics, University of Pennsylvania, Philadelphia,Pennsylvania
   Department of Family Medicine and Community Health, Perelman Schoolof Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
NR 0
TC 0
SN 1097-014
EI 0008-543
J9 Cancer
PD AUG 1
PY 2014
VL 120
IS 23
BP 3744
EP 51
DI 10.1002/cncr.28917 
PG -3693
WC Aged; Anastrozole; Androstadienes; adverse effects; Anxiety; psychology; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; complications; Depression; psychology; Electroacupuncture; methods; Fatigue; complications; Female; Humans; Letrozole; Middle Aged; Nitriles; adverse effects; Quality of Life; Sleep Wake Disorders; complications; Stress, Psychological; psychology; Treatment Outcome; Triazoles; adverse effects
UT PubMed:25077452
PM 25077452
DA 2014-08-01
ER

PT J
AU Peng, H
   Peng, HD
   Xu, L
   Lao, LX
AF Peng, Hao
   Peng, Hai-Dong
   Xu, Ling
   Lao, Li-Xing
TI [Efficacy of acupuncture in treatment of cancer pain: a systematic review].
SO Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
LA chi
DT Journal Article
AB BACKGROUND: Although acupuncture is a well-established treatment for cancer pain 
   and its effects have been widely reported in recent two decades, there is still 
   controversy over whether its efficacy is better than placebo. OBJECTIVE: To 
   evaluate the efficacy of acupuncture therapy on cancer pain. SEARCH STRATEGY: 
   Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 3, 
   2008), EMBASE, PubMed, ScienceDirect database, Current Controlled Trials, 
   Chongqin VIP database and CNKI database were searched, and the search date ended 
   in June 2008. The authors also hand-searched six Chinese Journals related to the 
   question. INCLUSION CRITERIA: All randomized controlled trials (RCTs) comparing 
   acupuncture therapy with placebo, Western drugs, Chinese herbal medicines, or 
   comparing acupuncture therapy plus drug treatment with drug treatment. DATA 
   EXTRACTION AND ANALYSIS: Two separate evaluators assessed the quality of the 
   included reports and extracted the useful information. Disagreements were 
   resolved through discussion. Meta-analysis of the included trials was done with 
   RevMan 5.0, and qualitative analysis was employed when meta-analysis was not 
   appropriate. RESULTS: Seven published RCTs with a total of 634 patients met the 
   inclusion criteria, and the quality of one of the included trials was high. Due 
   to flaws in design and reporting, meta-analysis was precluded, and only 
   qualitative analysis was done on the majority of the reports. The high-quality 
   trial showed that auricular acupuncture therapy was significantly superior to 
   placebo in pain alleviation. The other six low-quality trials with non-placebo 
   showed that acupuncture therapy had some positive effects. CONCLUSION: 
   Acupuncture is effective for pain relief. However, the poor quality of the 
   majority of the trials reduces the reliability of the conclusion. More 
   high-quality RCTs are needed to verify the effects.
C1 Department of Traditional Chinese Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
NR 0
TC 0
SN 
EI 1672-197
J9 Zhong Xi Yi Jie He Xue Bao
PD JUN 17
PY 2010
VL 8
IS 6
BP 501
EP 9
DI 10.3736/jcim20100601 
PG -492
WC Acupuncture Therapy; Humans; Neoplasms; complications; Pain; etiology; Pain Management; methods; Treatment Outcome
UT PubMed:20550871
PM 20550871
DA 2010-06-17
ER

PT J
AU Halámková, J
   Dymáčková, R
   Adámková, Krákorová D
AF Halámková, J
   Dymáčková, R
   Adámková Krákorová, D
TI Acupuncture from the perspective of evidence-based medicine - options of clinical 
SO Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti
LA English
DT Review
DE Acupuncture; Arthralgia; Fatigue; Myalgia; Pain; Vomiting; guidelines; pain; vasomotor symptoms
AB BACKGROUND: Acupuncture is one of the oldest therapeutic methods. The traditional 
   view of acupuncture is represented by influencing energy pathways through 
   stimulation of specific points. The original meridian theory, which works with 
   the assumption of normalization of the flowing energy Qi in the organism is, with 
   increasing evidence, supplemented with information about the bio-logical impact 
   of the use of acupuncture from the perspective of Western medicine. Specific 
   stimulation of particular points on the body leads to the activation of 
   hypothalamus and pituitary gland through neurotransmitters, resulting in a wide 
   range of systemic effects. Stimulation of nerves in the muscle, which then 
   trans-mits a signal to the spinal cord, midbrain, and hypothalamic-pituitary 
   system, releases neurotransmitters, endogenous opioid peptides, or hormones. 
   Stimulation of acupuncture points changes the levels of proinflammatory 
   cytokines, including IL-1-beta, IL-6, IL-17, and TNF-alpha. Currently, according 
   to the National Comprehensive Cancer Network (NCCN) guidelines, the following 
   symptoms are indicated for acupuncture treatment: pain including neuropathic 
   pain, arthralgia, and myalgia, especially in the aromatase inhibitors therapy, 
   nausea, and vomiting, fatigue, vasomotor symptoms in women and vasomotor symptoms 
   in men caused by androgen deprivation therapy. Acupuncture seems to be an 
   effective and safe treatment method for many of the cancer symptoms or the side 
   effects of cancer treatment, but, like any other treatment method, it has its 
   indications and contraindications. PURPOSE: This work aims to provide a 
   comprehensive overview of the use of acupuncture in defined indications, 
   according to current international guidelines. Thus, the therapeutic 
   possibilities of symptomatic treatment of cancer and therapy of adverse events of 
   oncological treatment can be extended.
NR 0
TC 0
SN 1802-530
EI 
J9 Klin Onkol
PD APR 24
PY 2022
VL 35
IS 2
BP 94
EP 99
DI 10.48095/ccko202294 
PG 5
WC Acupuncture Therapy; adverse effects; Androgen Antagonists; Evidence-Based Medicine; Humans; Male; Neurotransmitter Agents; Prostatic Neoplasms
UT PubMed:35459333
PM 35459333
DA 2022-04-24
ER

PT J
AU Xu, L
   Xu, T
AF Xu, Linling
   Xu, Tianshu
TI [A literature review on acupuncture and moxibustion for prevention and treatment 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Review
AB To explore the status of acupuncture and moxibustion for prevention and treatment 
   of lung cancer in current years; literature regarding acupuncture and moxibustion 
   for prevention and treatment of lung cancer between 2003 and 2013 from SCI 
   journals was retrieved and analyzed. As a result, 20 papers were included, which 
   were published in 17 journals including Journal of Clinical Oncology, Chest, 
   Respirology and Lung Cancer, etc. Of them, 3 papers discussed the effects of 
   acupuncture on progressing of lung cancer; 4 articles confirmed that acupuncture 
   could reduce myelosuppression and digestive tract reactions induced by 
   radiotherapy and chemotherapy; 6 papers showed that acupuncture could relieve 
   pain or fatigue of lung cancer; 3 papers indicated that acupuncture could 
   palliate dyspnea in lung cancer patients. It is concluded by domestic and 
   overseas researches that acupuncture and moxibustion are effective and safe for 
   symptoms of lung cancer, which is worthy of further study.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD OCT 21
PY 2015
VL 35
IS 6
BP 638
EP 40
DI 
PG -598
WC Acupuncture Therapy; Bibliometrics; Humans; Lung Neoplasms; prevention & control; Moxibustion; Publications; statistics & numerical data
UT PubMed:26480578
PM 26480578
DA 2015-10-21
ER

PT J
AU Wang, XQ
   Xiao, L
   Duan, PB
   Xu, Q
   Yang, LH
   Wang, AQ
   Wang, Y
AF Wang, Xiao-Qing
   Xiao, Lei
   Duan, Pei-Bei
   Xu, Qian
   Yang, Li-Hua
   Wang, A-Qin
   Wang, Yan
TI The feasibility and efficacy of perioperative auricular acupuncture technique via 
SO Explore (New York, N.Y.)
LA English
DT Journal Article
DE Auricular acupuncture; Gastric cancer; Intradermal needle; Movement-evoked pain; Randomized controlled trial
AB INTRODUCTION: Auricular acupuncture is widely used in the treatment of pain. 
   Recently, the most commonly used method of auricular acupuncture is to embed an 
   intradermal needle into the skin to enhance analgesia through continuous 
   stimulation. We aimed to explore the efficacy and feasibility of this form of 
   auricular acupuncture in the treatment of postoperative movement-evoked pain. 
   METHODS: This single-blind randomized controlled pilot trial was conducted 
   between 23/8/2019 and 10/1/2020. Forty patients were recruited and randomised to 
   either the control group (n = 20) or the experimental group (n = 20). Patients in 
   the control group received sham auricular acupuncture, while patients in the 
   experimental group received auricular acupuncture. A standard routine analgesia 
   was performed in both groups. The patients with NRS score≥4 were given rescue 
   analgesia. Postoperative pain, use of opioids and other analgesics, postoperative 
   recovery and patient's satisfaction were recorded. RESULTS: The credibility and 
   feasibility of auricular acupuncture for postoperative pain were high in both 
   groups. After auricular acupuncture, the scores of the postoperative 
   movement-evoked pain had a tendency to decrease, but no significant difference 
   was observed between two groups at any time point (P = 0.234∼0.888). The data on 
   postoperative pain at rest confirmed that no significant difference was observed 
   between two groups within 48 h of surgery (P = 0.134∼0.520), and the 
   postoperative pain at rest scores decreased over time; however, from the third 
   day, the pain at rest scores of the experimental group were decreased, and 
   significant differences were observed between the two groups (P = 0.039∼0.047). 
   As for use of rescue analgesic, total opioid consumption and the incidence of 
   postoperative nausea and vomiting, there were no significant differences between 
   the two groups (P = 0.311, P = 0.101, P = 0.661) . In terms of patients' 
   satisfaction, the score of the experimental group was higher than that of the 
   control group, and a significant difference was observed between the two groups 
   (P = 0.000). As for adverse events, two participants reported pain and one 
   patient reported discomfort at the insertion sites during the process of 
   auricular acupuncture intervention, but they both were minor and tolerable. 
   CONCLUSION: Auricular acupuncture may have a relief effect on mild postoperative 
   pain at rest with pain score below 3, suggesting that it may be a feasible 
   adjuvant method to relieve mild pain at rest. However, more multi-centre and 
   large-sample studies are needed to verify this result.
C1 Department of surgical oncology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road,Qinhuai District, Nanjing, Jiangsu 210029, China. 
   Department of Nursing, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, QinhuaiDistrict, Nanjing, Jiangsu 210029, China. 
   Department of Nursing, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, QinhuaiDistrict, Nanjing, Jiangsu 210029, China. 
   Anesthesiology and Pain Medicine, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road,Qinhuai District, Nanjing, Jiangsu 210029, China. 
   Department of Oncology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, QinhuaiDistrict, Nanjing, Jiangsu 210029, China,. 
   School of Nursing, Nanjing University of Chinese Medicine, 138 Xianlin Road, Qixia District, Nanjing, Jiangsu 210046, China. 
   Department of Nursing, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, QinhuaiDistrict, Nanjing, Jiangsu 210029, China. 
EM zyyssswy@sina.com
NR 0
TC 0
SN 1878-754
EI 
J9 Explore (NY)
PD OCT 14
PY 2021
VL 18
IS 1
BP 36
EP 43
DI 10.1016/j.explore.2021.09.007 
PG 7
WC Acupuncture, Ear; methods; Feasibility Studies; Gastrectomy; Humans; Pain, Postoperative; therapy; Pilot Projects; Single-Blind Method
UT PubMed:34642104
PM 34642104
DA 2021-10-14
ER

PT J
AU Jin, Y
   Zhou, J
   Xu, F
   Ren, Z
   Hu, J
   Zhang, C
   Ge, K
   Liu, L
AF Jin, Ying
   Zhou, Jie
   Xu, Fangfang
   Ren, Zeqin
   Hu, Jun
   Zhang, Cong
   Ge, Kaiwen
   Liu, Lanying
TI Electroacupuncture alleviates the transition from acute to chronic pain through 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE electroacupuncture; hyperalgesic priming; p38 mitogen-activated protein kinase; spinal dorsal horn; tumour necrosis factor alpha
AB BACKGROUND: Hyperalgesic priming (HP) is a model of the transition from acute to 
   chronic pain. Electroacupuncture (EA) could inhibit pain development through the 
   peripheral dorsal root ganglia; however, it is unclear whether it can mitigate 
   the transition from acute to chronic pain by attenuating protein expression in 
   the p38 MAPK (mitogen-activated protein kinase)/tumour necrosis factor alpha 
   (TNF-α) pathway in the spinal dorsal horn. AIMS: We aimed to determine whether EA 
   could prevent the transition from acute to chronic pain by affecting the p38 
   MAPK/TNF-α pathway in the spinal dorsal horn in a rat model established using HP. 
   METHODS: We first randomly subdivided 30 male Sprague-Dawley (SD) rats into 5 
   groups (n = 6 per group): control (N), sham HP (Sham-HP), HP, HP + SB203580p38 
   MAPK (HP+SB203580), and HP + Lenalidomide (CC-5013) (HP+Lenalidomide). We then 
   randomly subdivided a further 30 male SD rats into 5 groups (n = 6 per group): 
   Sham-HP, HP, sham EA (Sham EA), EA (EA), and EA + U-46619 p38 MAPK agonist 
   (EA+U-46619). We assessed the effects of EA on the mechanical paw withdrawal 
   threshold and p38 MAPK/TNF-α expression in the spinal dorsal horn of rats 
   subjected to chronic inflammatory pain. RESULTS: Rats in the EA group had reduced 
   p38 MAPK and TNF-α expression and had significantly reduced mechanical 
   hyperalgesia compared with rats in the other groups. CONCLUSION: Our findings 
   indicate that EA could increase the mechanical pain threshold in rats and inhibit 
   the transition from acute pain to chronic pain. This mechanism could involve 
   reduced p38 MAPK/TNF-α expression in the spinal dorsal horn.
C1 Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine,Nanjing City, China.
   The Second Affiliated Hospital of Zhejiang University School of Medicine, 
   The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, China.
   The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou City, China.
   Department of Rehabilitation in Traditional Chinese Medicine, The First Affiliated Hospital, Dali University, Dali City, China.
   Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine,Nanjing City, China.
   Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine,Nanjing City, China.
   Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine,Nanjing City, China.
   Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine,Nanjing City, China.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD JUL 27
PY 2021
VL 39
IS 6
BP 708
EP 715
DI 10.1177/09645284211020766 
PG 7
WC Acute Pain; genetics; Animals; Chronic Pain; genetics; Electroacupuncture; Humans; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord Dorsal Horn; metabolism; Tumor Necrosis Factor-alpha; genetics; p38 Mitogen-Activated Protein Kinases; genetics
UT PubMed:34308662
PM 34308662
DA 2021-07-27
ER

PT J
AU Mazzei, LG
   Bergamaschi, CC
   Silva, MT
   Barberato, Filho S
   Fulone, I
   Moura, MDG
   Guimaraes, C
   Lopes, LC
AF Mazzei, Lauren Giustti
   Bergamaschi, Cristiane de Cássia
   Silva, Marcus Tolentino
   Barberato Filho, Silvio
   Fulone, Izabela
   Moura, Mariana Del Grossi
   Guimaraes, Caio
   Lopes, Luciane Cruz
TI Use of IMMPACT domains in clinical trials of acupuncture for chronic pain: A 
SO PloS one
LA English
DT Journal Article
AB Acupuncture is one of the therapeutic resources used for the management of 
   chronic pain. Variability in outcome measurements in randomized clinical trials 
   of non-oncologic chronic pain (RCT-NOCP) generates inconsistencies in determining 
   effects of treatments. The objective of this survey was to assess the adherence 
   to the recommendations made by the Initiative on Methods, Measurement, and Pain 
   Assessment in Clinical Trials (IMMPACT) in the measurement of RCT-NOCP of 
   acupuncture. This methodological research made a systematic search for eligible 
   studies from different sources of information. Eligible studies included those 
   with number of patients ≥100, who randomized and allocated patients with chronic 
   non-oncologic pain to be treated with acupuncture or with "sham" acupuncture, or 
   non-acupuncture. This research included the recommendations for IMMPACT in the 
   measurement of RCT-NOCP: presence of outcomes pain, physical function, emotional 
   state and improvement perception of patient, the source of the outcome 
   information pain and the tools used to measure such domains. From a total of 
   1,386 studies, 24 were included in this survey. Eleven studies presented low risk 
   of bias. Pain outcome was measured in 23 studies, physical function in 22 
   studies, emotional state in 14 studies and improvement perception of patient in 
   one study. As for the pain outcome, the patient was the information source in 50% 
   of the studies. The measurement tools recommended for IMMPACT were included in 
   eight studies (35%) that evaluated pain, one study that evaluated the emotional 
   state (7%), and one study that evaluated the improvement perception and 
   satisfaction of patient. It was observed that studies which did not adhere to the 
   recommendations had more favorable results for acupuncture in the outcome pain. 
   This study concludes that randomized clinical trials that used acupuncture to 
   manage chronic pain failed to adhere to IMMPACT recommendations. Clinical 
   societies and IMMPACT do not share the same recommendations. This fact reflects 
   in the diversity of outcomes and instruments adopted in the studies, making it 
   difficult to compare the results.
C1 Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, State of São Paulo, Brazil.
   Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, State of São Paulo, Brazil.
   Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, State of São Paulo, Brazil.
   Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, State of São Paulo, Brazil.
   Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, State of São Paulo, Brazil.
   Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, State of São Paulo, Brazil.
   Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, State of São Paulo, Brazil.
   Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, State of São Paulo, Brazil.
NR 0
TC 0
SN 1932-620
EI 
J9 PLoS One
PD APR 17
PY 2020
VL 15
IS 4
BP e0231444
EP e0231444
DI 10.1371/journal.pone.0231444 
PG 1
WC Acupuncture Analgesia; methods; Adult; Aged; Chronic Pain; therapy; Female; Humans; Male; Middle Aged; Pain Measurement; methods; Randomized Controlled Trials as Topic; methods; Surveys and Questionnaires
UT PubMed:32298300
PM 32298300
DA 2020-04-17
ER

PT J
AU Zhou, Y
   Zhang, M
   Yang, C
   Li, SH
   Guixing, X
   Zihan, Y
   Sun, MS
   Yang, J
   Wang, YY
   Dai, W
   He, Y
   Han, L
   Lin, J
   Liang, FR
   Liu, F
AF Zhou, Yan
   Zhang, Mingming
   Yang, Chen
   Li, Shu-Hao
   Guixing, Xu
   Zihan, Yin
   Sun, Ming-Sheng
   Yang, Jiao
   Wang, Yang-Yang
   Dai, Wei
   He, Yueyi
   Han, Lin
   Lin, Jie
   Liang, Fan-Rong
   Liu, Fang
TI Effect of electroacupuncture versus sham electroacupuncture on postoperative 
SO BMJ open
LA English
DT Journal Article
DE Acupuncture; COMPLEMENTARY MEDICINE; GASTROENTEROLOGY; Gastrointestinal tumours
AB INTRODUCTION: Postoperative ileus (POI) is an inevitable complication after 
   abdominal surgery, often hindering recovery and prolonging hospital stay. Despite 
   the increasing use of electroacupuncture (EA) as an alternative treatment for 
   gastrointestinal dysfunction, its effectiveness for POI is still controversial. 
   This study aims to verify the efficacy and safety of EA in alleviating POI. 
   METHODS AND DESIGN: The study is a multicentre, randomised, sham-controlled 
   trial. A total of 174 patients undergoing laparoscopic surgery for left-sided 
   colorectal cancer will be randomly assigned to an EA group and a sham acupuncture 
   group at a ratio of 1:1. Treatment for both groups will commence on the first day 
   after the operation and continue once a day for four consecutive days. The 
   primary outcome is time to first defecation. Secondary outcomes include time to 
   first flatus, time to first tolerance to liquid and semiliquid diet, Functional 
   Assessment of Cancer Therapy-Colorectal (FACT-C, V.4.0), postoperative nausea and 
   vomiting, postoperative pain and abdominal distension, the Gastrointestinal 
   Quality of Life Index, Self-Rating Depression Scale, Self-Rating Anxiety Scale, 
   Gastrointestinal Symptom Rating Scale, length of the postoperative hospital stay, 
   time to first postoperative ambulation, evaluation of the expected value of 
   acupuncture, and satisfaction evaluation. ETHICS AND DISSEMINATION: The results 
   will be disseminated through peer-reviewed publications. This study protocol 
   (V.2.0, 1 October 2023) involves human participants and has been approved by the 
   Ethics Committee of Sichuan Cancer Hospital (number KY-2023-041-01), Meishan 
   Hospital of Traditional Chinese Medicine (number 2024LC001) and The Seventh 
   People's Hospital of Chengdu (number KY2024-001-01). Each individual who agrees 
   to participate in the research will provide written informed consent after the 
   objectives and procedures of this study are explained to them. TRIAL REGISTRATION 
   NUMBER: ChiCTR2400079645. Registered on 8 January 2024.
C1 Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
   Department of General Surgery, Sichuan University West China Hospital, Chengdu, Sichuan, China.
   Colorectal Cancer Center, Sichuan University West China Hospital, Chengdu, 
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
   Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
   Rehabilitation Medicine Center, Sichuan University West China Hospital, Chengdu, Sichuan, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
   Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated CancerHospital of University of Electronic Science and Technology of China, Chengdu,Sichuan, China.
   Meishan Hospital of Traditional Chinese Medicine, Chengdu, China.
   Seventh People's Hospital of Chengdu, Chengdu, China.
   Seventh People's Hospital of Chengdu, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
   Department of Integrated Chinese and Western Medicine, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center,Affiliated Cancer Hospital of University of Electronic Science and Technology ofChina, Chengdu, Sichuan, China liufang@scszlyy.org.cn.
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD DEC 27
PY 2024
VL 14
IS 12
BP e086438
EP e086438
DI 10.1136/bmjopen-2024-086438 
PG 1
WC Adult; Aged; Female; Humans; Male; Middle Aged; Colorectal Neoplasms; surgery; Electroacupuncture; methods; Ileus; etiology; Laparoscopy; adverse effects; Length of Stay; Multicenter Studies as Topic; Postoperative Complications; etiology; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:39725420
PM 39725420
DA 2024-12-27
ER

PT J
AU Mao, JJ
   Witt, CM
AF Mao, Jun J
   Witt, Claudia M
TI Acupuncture as an Evidence-Based Treatment for Cancer Pain Management: The Joint 
SO Journal of integrative and complementary medicine
LA English
DT Journal Article
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Institute for Complementary and Integrative Medicine, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
NR 0
TC 0
SN 2768-361
EI 
J9 J Integr Complement Med
PD FEB 28
PY 2023
VL 29
IS 4
BP 209
EP 211
DI 10.1089/jicm.2023.0018 
PG 2
WC Humans; United States; Integrative Oncology; Cancer Pain; therapy; Medical Oncology; Radiation Oncology; Acupuncture Therapy; Neoplasms; complications
UT PubMed:36847338
PM 36847338
DA 2023-02-28
ER

PT J
AU Yu, X
   Gong, SY
   Luo, Q
   Xu, GX
   Tian, H
   Li, Q
   Chen, M
   Yang, S
   Yu, SG
AF Yu, Xin
   Gong, Si-Yao
   Luo, Qin
   Xu, Gui-Xing
   Tian, Hao
   Li, Qian
   Chen, Ming
   Yang, Sha
   Yu, Shu-Guang
TI Effectiveness of Acupuncture in Improving Quality of Life for Patients with 
SO Chinese journal of integrative medicine
LA English
DT Journal Article
DE acupuncture; advanced cancer; meta-analysis; palliative care; quality of life
AB OBJECTIVE: To investigate the effect of acupuncture on advanced cancer patients 
   by meta-analysis. METHODS: Nine databases (the Cochrane Central Register of 
   Controlled Trials, MEDLINE, Web of Science, Embase, China National Knowledge 
   Infrastructure, the Cumulative Index to Nursing and Allied Health Literature, 
   Chinese Biomedical Literature Database, China Science and Technology Journal 
   Database, and WanFang Data) were searched for randomized controlled trials (RCTs) 
   on acupuncture in advanced cancer patients published from inception to February 
   13, 2023 and updated to June 1, 2023. Primary outcomes were quality of life 
   (QOL), while secondary outcomes were pain, fatigue, and adverse events (side 
   effects). Data synthesis was performed using RevMan V.5.3 to calculate pooled 
   effect sizes. RoB-2 was used for the risk of bias, and the quality of evidence 
   was assessed using the Grading of Recommendations, Assessment, Development, and 
   Evaluation (GRADE) tool. RESULTS: Totally 17 RCTs involving 1,178 participants 
   were included, 15 of which were pooled for meta-analysis. Most studies 
   demonstrated some concern for the overall risk of bias. The pooled data indicated 
   that acupuncture was associated with improved QOL [mean difference (MD)=6.67, 95% 
   confidence interval (CI): 5.09 to 8.26], pain (MD=-1.18, 95% CI -2.28 to -0.08), 
   and adverse events (risk ratio=0.30, 95% CI: 0.26 to 0.57) compared with control 
   groups. Fatigue outcome was not included. Heterogeneity was substantial, and 
   GRADE evidence was very low for both QOL and pain. CONCLUSIONS: Acupuncture could 
   benefit patients with advanced cancer and is considered safe compared with usual 
   care. However, the evidence regarding QOL and pain outcomes requires further 
   validation. It is crucial to encourage the development of high-quality studies to 
   strengthen this evidence. (Registry No. CRD42023423539).
C1 Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
   School of Health and Wellness, Panzhihua University, Panzhihua, Sichuan Province, 
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China. yangsha@cdutcm.edu.cn.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
NR 0
TC 0
SN 1993-040
EI 
J9 Chin J Integr Med
PD OCT 17
PY 2024
VL 31
IS 4
BP 360
EP 371
DI 10.1007/s11655-024-4119-4 
PG 11
WC Humans; Acupuncture Therapy; Neoplasms; pathology; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:39417952
PM 39417952
DA 2024-10-17
ER

PT J
AU Gao, X
   Zhang, SN
AF Gao, Xin
   Zhang, Shi-Nian
TI [Clinical observation of filiform fire needling on moderate and severe pain in 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE advanced cancer; analgesia; filiform fire needling; numerical rating scales (NRS); pain
AB OBJECTIVE: To evaluate the clinical effect of filiform fire needling on moderate 
   and severe pain in advanced cancer. METHODS: A total of 66 patients with moderate 
   and severe pain in advanced cancer were randomly divided into an observation 
   group (34 cases, 4 cases dropped off) and a control group (32 cases, 2 cases 
   dropped off). The two groups were treated with oral analgesics continuously for 4 
   weeks. The moderate pain patients was given bucinnazine hydrochloride tablets 
   (starting at 30 mg, once every 6 hours, increasing by 30%-50% until the titration 
   volume was reached), and the severe pain patients were given oxycodone 
   hydrochloride sustained-release tablets (starting at 20 mg every 12 hours and 
   increasing by 25%-50% until the titration volume was reached). The observation 
   group was cooperated with filiform fire needling at ashi point, Zusanli (ST 36), 
   Liangqiu (ST 34), Qihai (CV 6), Guanyuan(CV 4), Quchi (LI 11) and Waiguan (TE 5) 
   once every other day for 4 weeks. The changes of numerical rating scales (NRS) 
   scores were observed in both groups before and after treatment, and the amount of 
   analgesics and the incidence of adverse reactions were recorded. The clinical 
   effects in the two groups were evaluated. RESULTS: The effective rate was 90.0% 
   (27/30) in the observation group, which was higher than 66.7% (20/30) in the 
   control group (P<0.05). After treatment, the NRS scores of both groups were lower 
   than those before treatment (P<0.05), and the reducing degree in the observation 
   group was larger than that in the control group (P<0.05). The average dosage of 
   bunarizine hydrochloride tablets and oxycodone hydrochloride sustained release 
   tablets to titration volume in the observation group was less than that in the 
   control group (P<0.05). The incidence of adverse reactions was 23.3% (28/120) in 
   the observation group, which was lower than 44.2% (53/120) in the control group 
   (P<0.05). CONCLUSION: Filiform fire needling can alleviate pain symptoms of 
   patients with moderate and severe pain in advanced cancer, reduce the amount of 
   analgesics, and decrease the incidence of adverse reactions.
C1 Graduate School of Nanjing University of Chinese Medicine, Nanjing 210046, Jiangsu Province, China.
   Massage Department of Jiangsu Provincial Hospital of TCM.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUN 17
PY 2020
VL 40
IS 6
BP 601
EP 4
DI 10.13703/j.0255-2930.20190531-k0001 
PG -597
WC Acupuncture Points; Acupuncture Therapy; Analgesics; therapeutic use; Cancer Pain; therapy; Humans; Neoplasms; complications; Oxycodone; therapeutic use; Pain Management; Piperazines; therapeutic use; Treatment Outcome
UT PubMed:32538009
PM 32538009
DA 2020-06-17
ER

PT J
AU Lian, WL
   Pan, MQ
   Zhou, DH
   Zhang, ZJ
AF Lian, Wei-Ling
   Pan, Min-qi
   Zhou, Dai-han
   Zhang, Zhang-jin
TI Effectiveness of acupuncture for palliative care in cancer patients: a systematic 
SO Chinese journal of integrative medicine
LA English
DT Journal Article
AB OBJECTIVE: To critically evaluate the currently available randomized clinical 
   trials regarding the effectiveness of acupuncture in palliative care for cancer 
   patients, hence, to provide sufficient evidences for the widespread use of 
   acupuncture in cancer treatment. METHODS: Two independent reviewers extracted 
   data from all of the randomized clinical trials (RCTs) that assessed the efficacy 
   of acupuncture in palliative care for cancer patients. Seven databases were 
   searched from their respective inception to December 2010. All eligible trials 
   identified were evaluated by two independent reviewers using the Jadad scale, and 
   data from the articles were validated and extracted. RESULTS: In total, 33 RCTs 
   met the inclusion criteria. The effects of acupuncture on different 
   cancer-related aspects were shown, including chemotherapy or radiotherapy-induced 
   side effects (13/33, 39.4%), cancer pain (6/33, 18.2%), post-operative urinary 
   retention (4/33, 12.1%), quality of life (2/33, 6.1%), vasomotor syndrome (2/33, 
   6.1%), post-operative gastrointestinal dysfunction (2/33, 6.1%), prevention of 
   prolonged postoperative ileus (2/33, 6.1%), joint symptoms (1/33, 3.0%), and 
   immunomodulation (1/33, 3.0%). CONCLUSIONS: The result of our systematic review 
   suggested that the effectiveness of acupuncture in palliative care for cancer 
   patients is promising, especially in reducing chemotherapy or radiotherapyinduced 
   side effects and cancer pain. Acupuncture may be an appropriate adjunctive 
   treatment for palliative care.
C1 School of Chinese Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China, 13902206571@139.com.
NR 0
TC 0
SN 1993-040
EI 
J9 Chin J Integr Med
PD DEC 18
PY 2013
VL 20
IS 2
BP 136
EP 47
DI 10.1007/s11655-013-1439-1 
PG -89
WC Acupuncture Therapy; adverse effects; Drug Therapy; Humans; Neoplasms; surgery; Palliative Care; Postoperative Complications; etiology; Quality of Life; Radiotherapy; adverse effects; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:24338183
PM 24338183
DA 2013-12-18
ER

PT J
AU Liu, WH
   Liu, WT
   Liang, Y
   Guo, ZN
   Huang, LT
   Zhang, HB
   Xu, NG
   He, YH
AF Liu, Wen-Hao
   Liu, Wen-Ting
   Liang, Ying
   Guo, Zi-Ning
   Huang, Le-Tian
   Zhang, Hai-Bo
   Xu, Neng-Gui
   He, Yi-Han
TI Molecular mechanism of basolateral amygdala involved in 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Basolateral amygdala; Cancer pain; Depression; Electroacupuncture; Transcriptomics
AB OBJECTIVES: To observe the effect of electroacupuncture (EA) of "Zusanli" (ST36) 
   and "Sanyinjiao" (SP6) on cancer pain and concomitant negative emotion in cancer 
   pain model mice, and to explore its molecular mechanisms in the basolateral 
   amygdala (BLA) by using transcriptomics techniques. METHODS: C57BL/6 mice were 
   randomized into sham operation, model and EA groups, with 10 mice in each group. 
   The cancer pain model was established by injecting PBS suspension containing 
   Lewis lung cancer cells into the femur. The mice in the EA group received EA 
   stimulation(1 mA, 2 Hz) on ST36 and SP6 from the 10(th) day after modeling, 20 
   min per day for 12 successive days. The bone damage of the distal femur was 
   observed with X-ray and H.E. staining, respectively. The mechanical pain 
   threshold (MPT) was detected by using von Frey. The depression-like behavior was 
   detected by using sucrose-preference test (sucrose preference index in 12 h), and 
   the immobility (feeling of despair) duration of forced swimming within 4 min. The 
   BLA tissue was extracted for RNA sequencing (RNA library construction, and 
   screening differential gene profiling by transcriptomic sequencing) and 
   bioinformatics analysis. The real-time PCR was used to validate the mRNA 
   expression of differentially expressed genes：tumor necrosis factor superfamily 8 
   (Tnfsf8), bone marrow stromal cell antigen 1 (Bst1), prodynorphin (Pdyn) and 
   voltage-gated sodium channelβ4 (Scn4b). RESULTS: H.E. staining and X-ray showed 
   significant bone damage in the distal femur in cancer pain mice. In contrast to 
   the sham operation group, the MPT on the 1(st) , 4(th), 7(th) , 10(th), 14(th) 
   and 21(st) day after modeling and sucrose preference index were significantly 
   decreased (P<0.001, P<0.000 1), and the immobility time of the forced swimming 
   was considerably increased in the model group (P<0.001). In contrast to the model 
   group, the MPT values on the 14(th) and 21(st) day and sucrose preference index 
   were obviously increased (P<0.000 1, P<0.05), and the immobility time was 
   strikingly decreased in the EA group (P<0.01). RNA sequencing showed that a total 
   of 404 differentially expressed genes (205 up-regulated, 199 down-regulated) were 
   screened in the model group compared with the sham operation group, and a total 
   of 329 differentially expressed genes (206 up-regulated and 123 down-regulated) 
   were screened in the EA group compared with the model group. Venn diagram 
   analysis of the differentially expressed genes showed that 45 up-regulated and 28 
   down-regulated genes in the model group were completely reversed by EA. Gene 
   Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of the 
   screened differentially expressed genes revealed that the above differential 
   genes were mainly enriched in the ligand receptor activity, cytokine receptor 
   binding, and cytokine activity related to neuro-inflammation, as well as in 
   neuropeptide signaling pathways related to neuronal excitability, and calcium ion 
   mediated signal transduction. The analysis of KEGG pathway showed that the 
   differentially expressed genes were mainly enriched in the inflammation-related 
   pathways, such as interleukin-17 pathway. Validation analysis of the 
   differentially expressed genes showed that the expression levels of Tnfsf8 and 
   Bst1 were significantly up-regulated in the model group compared with the sham 
   operation group (P<0.01, P<0.05), and down-regulated by EA (P<0.01, P<0.05), 
   while the expression levels of Pdyn and Scn4b were down-regulated in the model 
   group in comparison with the sham operation group (P<0.01), and up-regulated by 
   EA (P<0.05, P<0.01), which was consistent with the changing trend of the gene 
   sequencing results. CONCLUSIONS: Acupuncture of ST36 and SP6 can significantly 
   relieve cancer pain and concomitant negative emotion in cancer pain mice, which 
   may be related to its functions in alleviating neuro-inflammation and relieving 
   the abnormal activities of specific neurons in the BLA.
C1 Medical College of Acupuncture and Rehabilitation of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
   Medical College of Acupuncture and Rehabilitation of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
   Medical College of Acupuncture and Rehabilitation of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
   Medical College of Acupuncture and Rehabilitation of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
   Medical College of Acupuncture and Rehabilitation of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
   The Second Affiliated Hospital of Guangzhou University of Chinese Medicine / Guangdong Hospital of TCM, Guangzhou 510120.
   State Key Laboratory of Moisture Syndrome of Traditional Chinese Medicine, 
   Medical College of Acupuncture and Rehabilitation of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
   South China Research Center for Acupuncture and Moxibustion of Guangzhou 
   The Second Affiliated Hospital of Guangzhou University of Chinese Medicine / Guangdong Hospital of TCM, Guangzhou 510120. yihanhe@gzucm.edu.cn.
   State Key Laboratory of Moisture Syndrome of Traditional Chinese Medicine, 
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUL 18
PY 2024
VL 49
IS 7
BP 667
EP 677
DI 10.13702/j.1000-0607.20231005 
PG 10
WC Animals; Electroacupuncture; Mice; Mice, Inbred C57BL; Depression; therapy; Humans; Cancer Pain; therapy; Male; Basolateral Nuclear Complex; metabolism; Transcriptome; Female; Acupuncture Points; Enkephalins; metabolism
UT PubMed:39020484
PM 39020484
DA 2024-07-18
ER

PT J
AU Ho, EY
   Thompson-Lastad, A
   Lam, R
   Zhang, X
   Thompson, N
   Chao, MT
AF Ho, Evelyn Y
   Thompson-Lastad, Ariana
   Lam, Rachele
   Zhang, Xiaoyu
   Thompson, Nicole
   Chao, Maria T
TI Adaptations to Acupuncture and Pain Counseling Implementation in a Multisite 
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
DE acupuncture; cancer; implementation; inpatient; pain; pragmatic effectiveness
AB Objectives: As part of a pragmatic effectiveness trial of integrative pain 
   management among inpatients with cancer, the authors sought to understand the 
   clinical context and adaptations to implementation of two study interventions, 
   acupuncture and pain counseling (i.e., pain education and coping skills). Design: 
   The larger study uses a 2 × 2 factorial design with inpatients randomized to: (1) 
   usual care (UC), (2) UC with acupuncture, (3) UC with pain counseling, and (4) UC 
   with acupuncture and pain counseling. The study is being conducted in two 
   hospitals (one academic and one public) and three languages (Cantonese, English, 
   and Spanish). The authors conducted a process evaluation by interviewing study 
   interventionists. Analysis included deductive coding to describe context, 
   intervention, implementation, and inductive thematic coding related to 
   intervention delivery. Results: Interviewees included seven acupuncturists and 
   four pain counselors. Qualitative themes covered adaptations and recognizing 
   site-specific differences that affected implementation. Interventionists adhered 
   closely to protocols and made patient-centered adaptations that were then 
   standardized in broader implementation (e.g., including caregivers in pain 
   counseling sessions; working in culturally nuanced ways with non-English-speaking 
   patients). The public hospital included more patients with recent diagnoses and 
   advanced disease, more ethnically and linguistically diverse patients, less 
   continuity of staffing, and shared patient rooms. At the academic medical center, 
   more patients were familiar with integrative therapies and all were located in 
   single rooms. Providing acupuncture to hospital staff was a key strategy to 
   establish trust, experientially explain the intervention, and create camaraderie 
   and staff buy-in. Conclusions: Providing nonpharmacologic interventions for a 
   pragmatic trial requires adapting to a range of clinical factors. Site-specific 
   factors included greater coordination and resources needed for successful 
   implementation in the public hospital. The authors conclude that adaptation to 
   context and individual patient needs can be done without compromising 
   intervention fidelity and that intervention design should apply principles such 
   as centering at the margins to reduce participation barriers for diverse patient 
   populations.
C1 Department of Communication Studies, University of San Francisco, San Francisco, CA, USA.
   Asian American Research Center on Health and University of California, San 
   Osher Center for Integrative Medicine, University of California, San Francisco, San Francisco, CA, USA.
   Department of Family and Community Medicine and Division of General Internal 
   Osher Center for Integrative Medicine, University of California, San Francisco, San Francisco, CA, USA.
   Osher Center for Integrative Medicine, University of California, San Francisco, San Francisco, CA, USA.
   Osher Center for Integrative Medicine, University of California, San Francisco, San Francisco, CA, USA.
   Osher Center for Integrative Medicine, University of California, San Francisco, San Francisco, CA, USA.
   Department of Medicine, Division of General Internal Medicine at Zuckerberg San 
NR 0
TC 0
SN 1557-770
EI 1075-553
J9 J Altern Complement Med
PD APR 28
PY 2021
VL 27
IS 5
BP 398
EP 406
DI 10.1089/acm.2020.0387 
PG 8
WC Acupuncture Therapy; Adult; Cancer Pain; therapy; Counseling; Female; Humans; Integrative Medicine; Male; Middle Aged; Pain Management; Qualitative Research; Randomized Controlled Trials as Topic; Treatment Outcome; Young Adult
UT PubMed:33902333
PM 33902333
DA 2021-04-28
ER

PT J
AU Tan, J
   Feng, Y
   Liu, H
   Zhou, Y
   Cai, J
   Jiang, Y
   Li, P
   Gu, L
   Song, Z
AF Tan, Jing
   Feng, Yong
   Liu, Hui
   Zhou, Yihu
   Cai, Jiaqin
   Jiang, Yueyi
   Li, Pengyi
   Gu, Lianbing
   Song, Zhenghuan
TI Effect of press needle stimulation on postoperative pulmonary complications in 
SO Annals of medicine
LA English
DT Journal Article
DE Press needle; postoperative pain control; postoperative pulmonary complications; video-assisted thoracoscopic surgery
AB BACKGROUND: Patients undergoing high-risk surgical procedures frequently 
   experience postoperative pulmonary complications (PPCs) that impact outcomes. 
   Acupuncture has demonstrated potential benefits during surgery. Press needle 
   stimulation is increasingly recognized as an alternative to conventional 
   techniques. We aimed to evaluate the effect of press needle stimulation on PPCs 
   in patients with lung cancer undergoing video-assisted thoracoscopic surgery. 
   METHODS: Eighty-seven patients undergoing video-assisted thoracoscopic surgery 
   were randomized into press needle (n = 48) or sham needle (n = 39) groups. The 
   press needle group underwent bilateral stimulation of acupoints LU9 (Taiyuan), 
   RN17 (Danzhong), LU6 (Kongzui), and BL13 (Feishu) before anesthesia and during 
   surgery. The sham group received a placebo stimulation. The primary endpoint was 
   the incidence of PPCs within seven days post-surgery. The secondary endpoints 
   included cytokine levels, intraoperative respiratory mechanics, postoperative 
   pain score, analgesic consumption, and related complications. RESULTS: Press 
   needle acupoint stimulation was associated with a significantly lower incidence 
   of PPCs than the sham needle group. Perioperative data, tachycardia, cough, 
   postoperative nausea, vomiting, and most inflammatory markers exhibited no 
   significant differences, except for lower hypoxia-inducible factor-1α levels in 
   the press needle group. Hemodynamic and blood gas analyses indicated no 
   significant cardiovascular or respiratory differences between groups. The press 
   needle group exhibited reduced patient-controlled analgesia (PCA) pump 
   utilization and lower total PCA usage, indicating improved pain management. 
   CONCLUSION: This study indicates that press needle stimulation lowers PPC 
   incidence and improves postoperative analgesia in patients with lung cancer 
   undergoing video-assisted thoracoscopic lobectomy.
C1 Department of Anesthesiology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University,Nanjing, People's Republic of China.
   Department of Radiology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer 
   Nanjing Medical University, Nanjing, People's Republic of China.
   Department of Anesthesiology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University,Nanjing, People's Republic of China.
   Xuzhou Medical University, Xuzhou, People's Republic of China.
   Department of Radiology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University,Nanjing, People's Republic of China.
   Xuzhou Medical University, Xuzhou, People's Republic of China.
   Department of Anesthesiology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University,Nanjing, People's Republic of China.
   Department of Anesthesiology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University,Nanjing, People's Republic of China.
   Department of Radiology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer 
   Department of Anesthesiology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University,Nanjing, People's Republic of China.
NR 0
TC 0
SN 1365-206
EI 0785-389
J9 Ann Med
PD SEP 15
PY 2025
VL 57
IS 1
BP 2560684
EP 2560684
DI 10.1080/07853890.2025.2560684 
PG 0
WC Humans; Thoracic Surgery, Video-Assisted; adverse effects; Male; Female; Middle Aged; Aged; Lung Neoplasms; surgery; Postoperative Complications; prevention & control; Acupuncture Therapy; methods; Pain, Postoperative; prevention & control; Acupuncture Points; Lung Diseases; etiology; Needles; Treatment Outcome
UT PubMed:40953233
PM 40953233
DA 2025-09-15
ER

PT J
AU Anshasi, HA
   Ahmad, M
AF Anshasi, Huda A
   Ahmad, Muayyad
TI An assessment of methodological quality of systematic reviews of acupuncture and 
SO Complementary therapies in clinical practice
LA English
DT Journal Article
DE A systematic literature review; Acupuncture; Cancer-related pain; Meta-analyses; Patients with cancer
AB BACKGROUND AND PURPOSE: There currently exist many systematic reviews aimed at 
   assessing acupuncture and related therapy effectiveness in cancer-related pain 
   management. However, the methodological quality of existing systematic reviews 
   remains unclear. The purpose of this review was to summarize and evaluate the 
   methodological quality of these systematic reviews and meta-analyses papers. 
   METHODS: A comprehensive search on multiple databases was performed using 
   Assessing the Methodological Quality of Systematic Reviews (AMSTAR). RESULTS: 
   Fourteen systematic reviews published between 2005 and 2017 were eligible for 
   inclusion. The consensus across the included reviews was that acupuncture and 
   related therapies alone did not have superior pain-relieving effects as compared 
   with analgesic administration using various validated pain scales. However, as 
   compared with analgesic administration alone, acupuncture and related therapies 
   plus analgesics resulted in reduced cancer related-pain. CONCLUSION: The study 
   findings emphasized that acupuncture and related therapies alone did not have 
   clinically significant effects at cancer-related pain reduction as compared with 
   analgesic administration alone. Clinicians may consider acupuncture and related 
   therapies as adjunctive therapies for cancer-related pain management, in 
   particular, when pain control is unsatisfactory under analgesics alone. 
   Furthermore, the researchers should conduct the SRs and meta-analyses according 
   to the AMSTAR and PRISMA.
C1 The University of Jordan, School of Nursing, Amman, Jordan. 
   The University of Jordan, School of Nursing, Amman, Jordan. 
EM mma4jo@yahoo.com
NR 0
TC 0
SN 1873-694
EI 
J9 Complement Ther Clin Pract
PD JUL 31
PY 2018
VL 32
IS 
BP 163
EP 168
DI 10.1016/j.ctcp.2018.06.013 
PG 5
WC Acupuncture Therapy; Cancer Pain; therapy; Humans
UT PubMed:30057045
PM 30057045
DA 2018-07-31
ER

PT J
AU Zhou, XY
   Wang, XY
   Zhang, YF
   Wang, XL
   Zhang, XX
   Liu, YY
   Li, PY
   Tian, YS
AF Zhou, Xing-Yu
   Wang, Xin-Yi
   Zhang, Yu-Fei
   Wang, Xiao-Long
   Zhang, Xiu-Xiu
   Liu, Yuan-Yuan
   Li, Peng-Yan
   Tian, Yuan-Sheng
TI [Clinical observation on treatment of patients with kidney-yang deficiency type 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acupoint embedding therapy; Ankylosing spondylitis; Bushen Tongdu external treatment method; Kidney- yang deficiency; Ren Du Zhou-Tian moxibustion
AB OBJECTIVES: To observe and evaluate the effectiveness and safety of Bushen Tongdu 
   (reinforcing the kidney-yang and regulating the Governor Vessel) external 
   treatment for patients with kidney-yang deficiency type ankylosing spondylitis 
   (AS). METHODS: Patients with Kidney-yang deficiency type AS were randomly divided 
   into an observation group(36 cases, 4 cases dropped out) and a control group(36 
   cases, 3 cases dropped out). The observation group were received the Bushen 
   Tongdu external treatment which was a combination of Ren Du Zhou-Tian moxibustion 
   and acupoint embedding therapy, i.e. performing ginger-juice soaked nonwoven 
   separated moxibustion first at the back covering the region from Dazhui (GV14) to 
   Yaoshu (GV2) for 1 h, and then at the thoracoabdominal region covering the part 
   from Tiantu (CV22) to Zhongji (CV3) for 1 h, followed by performing acupoint 
   catgut embedding at one or two pairs of GV14, Shenshu (BL23), Dachangshu (BL25), 
   Xuehai (SP10), and Zusanli (ST36), once a week, for 8 weeks. The control group 
   received oral administration of salazosulfapyridine capsules (0.2 g/time), once a 
   day for 8 weeks. Changes of the patients' conditions were evaluated by using 
   traditional Chinese medicine (TCM) syndrome score (0 to 3 points for cold and 
   painful lower back, morning stiffness, limited lumbar movement, soreness and 
   weakness of waist and knees, etc.) and the total score (0 to 18 points), the Bath 
   ankylosing spondylitis disease activity index (BASDAI) score (0 to 10 points for 
   fatigue, physical discomfort caused by pain, swelling, or tenderness in the spine 
   and peripheral joints, duration and severity of morning stiffness, etc). The 
   therapeutic effect was assessed . The safety observation included fainting during 
   acupuncture or moxibustion treatment, burn, etc. The contents of serum 
   interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and matrix 
   metalloproteinase-3 (MMP-3) were detected before and after the treatment. 
   RESULTS: After 8 weeks of treatment, the TCM syndrome score, total score, BASDA 
   score, contents of serum IL-6, TNF-α and MMP-3 were strikingly decreased in both 
   groups compared with those of their own pre-treatment (P<0.05), and the 
   therapeutic effect of the observation group was significantly superior to that of 
   the control group in lowering the scores of cold and painful lower back, weakness 
   in the lower back and knees, preference for warmth and aversion to cold, pain 
   worsened by cold, and total score, BASDA score, and contents of serum IL-6, TNF-α 
   and MMP-3 (P<0.05). The total effective rate of observation group was 90.63% 
   (29/32), which was higher (P<0.05) than that of control group (75.76%, 25/33). 
   CONCLUSIONS: The Bushen Tongdu external treatment method significantly improves 
   AS patients' TCM clinical symptoms, alleviates inflammatory reactions, and 
   demonstrates a significant efficacy with good safety.
C1 Department of Pain and Rheumatology, Henan Integrated Medicine Hospital, Zhengzhou 450004, China.
   Department of Pain and Rheumatology, Henan Integrated Medicine Hospital, Zhengzhou 450004, China.
   Department of Pain and Rheumatology, Henan Integrated Medicine Hospital, Zhengzhou 450004, China.
   School of Acupuncture-Moxibustion and Tuina, Henan University Of Chinese Medicine, Zhengzhou 450046.
   School of Acupuncture-Moxibustion and Tuina, Henan University Of Chinese Medicine, Zhengzhou 450046.
   School of Acupuncture-Moxibustion and Tuina, Henan University Of Chinese Medicine, Zhengzhou 450046.
   School of Acupuncture-Moxibustion and Tuina, Henan University Of Chinese Medicine, Zhengzhou 450046.
   Department of Pain and Rheumatology, Henan Integrated Medicine Hospital, Zhengzhou 450004, China. 1619166115@qq.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD MAR 10
PY 2025
VL 50
IS 2
BP 183
EP 189
DI 10.13702/j.1000-0607.20231040 
PG 6
WC Humans; Spondylitis, Ankylosing; therapy; Female; Male; Adult; Acupuncture Points; Yang Deficiency; therapy; Middle Aged; Acupuncture Therapy; Young Adult; Drugs, Chinese Herbal; administration & dosage; Kidney; physiopathology; Treatment Outcome; Tumor Necrosis Factor-alpha; blood; Moxibustion; Interleukin-6; blood
UT PubMed:40059052
PM 40059052
DA 2025-03-10
ER

PT J
AU Huang, XB
   Chen, YQ
   Xie, DY
   Chen, RX
AF Huang, Xian-Bao
   Chen, Yan-Qi
   Xie, Ding-Yi
   Chen, Ri-Xin
TI [Application of professor CHEN Ri-xin's academic thought "yang is often 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE CHEN Ri-xin; experience of famous doctor; heat-sensitive moxibustion; tumor; yang is often insufficient; yin is often surplus
AB Professor CHEN Ri-xin has explored the causes of the characteristics of TCM 
   syndromes in modern disease spectrum and pointed out that the TCM syndromes are 
   generally characterized by "yang is often insufficient, but yin is often 
   surplus". Based on the clinical experience and the understanding of TCM classics 
   and ancient literature on tumor, professor CHEN has proposed that TCM syndromes 
   of patients with advanced tumor are also generally characterized by "yang is 
   often insufficient, but yin is often surplus". The heat-sensitive moxibustion has 
   the functions of warming and nourishing yang-qi, eliminating dampness, warming 
   meridians and dispersing cold, activating blood circulation and clearing 
   collaterals, therefore tumor patients with deficiency syndrome (yang-deficiency, 
   qi-deficiency), cold syndrome, dampness syndrome, phlegm syndrome and 
   blood-stasis syndrome belonging to the indications of heat-sensitive moxibustion. 
   The heat-sensitive moxibustion has unique advantages in treating spleen-stomach 
   dysfunction after chemotherapy and radiotherapy, bone marrow suppression after 
   chemotherapy and radiotherapy, cancerous deficiency, cancerous pain, pleural 
   effusion, ascites, constipation, which has important clinical value in improving 
   the quality of life and prolonging the life time for patients with advanced 
   tumors.
C1 Affiliated Hospital of Jiangxi University of TCM, Nanchang 330006, China.
   College of Acupuncture-Moxibustion and Tuina, Jiangxi University of TCM.
   Affiliated Hospital of Jiangxi University of TCM, Nanchang 330006, China.
   Affiliated Hospital of Jiangxi University of TCM, Nanchang 330006, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JAN 14
PY 2020
VL 40
IS 1
BP 79
EP 83
DI 10.13703/j.0255-2930.20190701-k0003 
PG 4
WC Hot Temperature; Humans; Medicine, Chinese Traditional; Moxibustion; Neoplasms; therapy; Quality of Life
UT PubMed:31930904
PM 31930904
DA 2020-01-14
ER

PT J
AU Wang, P
   Xie, F
   Zhang, L
   Zhao, S
   Zhu, L
   Shen, S
   Li, D
   Chen, Z
   Xiao, R
   Lu, Y
   Lei, X
   Li, Y
   Zhang, G
   Zeng, W
   Wang, X
AF Wang, Peiru
   Xie, Fang
   Zhang, Linglin
   Zhao, Shuang
   Zhu, Lude
   Shen, Shuzhan
   Li, Dongsheng
   Chen, Zhou
   Xiao, Rong
   Lu, Yan
   Lei, Xia
   Li, Yan
   Zhang, Guolong
   Zeng, Weihui
   Wang, Xiuli
TI Plum-blossom needle tapping enhances the efficacy of ALA photodynamic therapy for 
SO Photodiagnosis and photodynamic therapy
LA English
DT Journal Article
DE Actinic keratosis; Photodynamic therapy; Plum-blossom needle
AB BACKGROUND: Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is a 
   reliable treatment for actinic keratosis (AK), but its effect needs to be 
   enhanced in thick lesions. Plum-blossom needle is a traditional Chinese 
   cost-effective instrument for enhancing the transdermal delivery of ALA. However, 
   whether it could improve the efficacy of AK treatment has not yet been 
   investigated. OBJECTIVE: To compare the efficacy and safety of plum-blossom 
   needle-assisted PDT in facial AK in the Chinese population. METHODS: In this 
   multicenter, prospective study, a total of 142 patients with AKs (grades I-III) 
   were randomized into the plum-blossom needle-assisted PDT group (P-PDT) and 
   control PDT group (C-PDT). In the P-PDT group, each AK lesion was tapped 
   vertically by a plum-blossom needle before the application of 10% ALA cream. In 
   the C-PDT group, each lesion was only wiped with regular saline before ALA cream 
   incubation. Then, 3 hours later, all the lesions were irradiated with 
   light-emitting diode (LED) at a wavelength of 630 nm. PDT was performed once 
   every 2 weeks until all lesion patients achieved complete remission or completed 
   six sessions. The efficacy (lesion response) and safety (pain scale and adverse 
   events) in both groups were evaluated before each treatment and at every 
   follow-up visit at 3-month intervals until 12 months. RESULTS: In the P-PDT and 
   C-PDT groups, the clearance rates for all AK lesions after the first treatment 
   were 57.9% and 48.0%, respectively (P < 0.05). For grade I AK lesions, the 
   clearance rates were 56.5% and 50.4%, respectively (P = 0.34). For grade II AK 
   lesions, the clearance rates were 58.0% and 48.9%, respectively (P = 0.1). For 
   grade III AK lesions, the clearance rates were 59.0% and 44.2%, respectively (P < 
   0.05). Moreover, grade III AK lesions in the P-PDT group required fewer treatment 
   sessions (P < 0.05). There was no significant difference in the pain score 
   between the two groups (P = 0.752). CONCLUSION: Plum-blossom needle tapping may 
   enhance the efficacy of ALA-PDT by facilitating ALA delivery in the treatment of 
   AK.
C1 Shanghai Skin Disease Hospital, School of Medicine, Institute of Photomedicine, Tongji University, Shanghai, PR China.
   Department of Dermatology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, PR China.
   Shanghai Skin Disease Hospital, School of Medicine, Institute of Photomedicine, Tongji University, Shanghai, PR China.
   Xiangya Hospital Central South University, Changsha, PR China.
   Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
   Shanghai Skin Disease Hospital, School of Medicine, Institute of Photomedicine, Tongji University, Shanghai, PR China.
   Wuhan No. 1 Hospital, Dermatology, Wuhan, PR China.
   Peking University People's Hospital, Beijing, PR China.
   Xiangya Hospital Central South University, Changsha, PR China.
   Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China.
   Department of Dermatology, Department of Dermatology, Daping Hospital, The Army Medical University, Chongqing, PR China.
   Department of Dermatology, Henan Provincial People's Hospital, Zhengzhou, PR China.
   Shanghai Skin Disease Hospital, School of Medicine, Institute of Photomedicine, Tongji University, Shanghai, PR China.
   Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. 
   Shanghai Skin Disease Hospital, School of Medicine, Institute of Photomedicine, Tongji University, Shanghai, PR China. 
EM angxiuli_1400023@tongji.edu.cn
NR 0
TC 0
SN 1873-159
EI 
J9 Photodiagnosis Photodyn Ther
PD MAY 22
PY 2023
VL 42
IS 
BP 103611
EP 103611
DI 10.1016/j.pdpdt.2023.103611 
PG 0
WC Humans; Aminolevulinic Acid; administration & dosage; East Asian People; Keratosis, Actinic; drug therapy; Pain; etiology; Photochemotherapy; methods; Photosensitizing Agents; administration & dosage; Prospective Studies; Treatment Outcome; Single-Blind Method; Administration, Cutaneous; Skin Cream; administration & dosage; Face; Dry Needling; instrumentation; Acupuncture Therapy; instrumentation
UT PubMed:37211296
PM 37211296
DA 2023-05-22
ER

PT J
AU Lu, YZ
   Chen, YX
   Qian, Y
   Yu, ML
   Lu, SF
AF Lu, Yi-Zhou
   Chen, Yu-Xuan
   Qian, Yi
   Yu, Mei-Ling
   Lu, Sheng-Feng
TI [Bibliometric analysis on the clinical researches of tumor treated with 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture-moxibustion; bibliometrics; clinical research; tumor
AB OBJECTIVE: To analyze the literature characteristics of the clinical researches 
   on tumor treatment with acupuncture-moxibustion in PubMed database so as to 
   provide the references for the study of acupuncture-moxibusion in intervention of 
   tumor. METHODS: The articles on the clinical researches of acupuncture-moxibusion 
   in treatment of tumor were retrieved from PubMed database listed till December 
   31, 2018. Using bibliometric methodology, the analysis was conducted on 
   publication year, publication journal, author, country or region, research 
   institution, disease spectrum and therapeutic regimen. RESULTS: A total of 143 
   articles are included. The publications are increased steadily since 2004. The 
   articles are published in 64 international journals, of which, Acupuncture in 
   Medicine (12 articles) and Integrative Cancer Therapies (10 articles) occupy the 
   the largest number of publications. They are distributed in 18 countries and 
   regions, of which, the top two countries are America (44 articles) and China (34 
   articles. The involved types of cancer include breast cancer, prostate cancer, 
   gastric cancer, etc. Acupuncture-moxibustion is mainly for complication and the 
   comorbid disorders after treatment, such as pain, nausea and vomiting and fatigue 
   at most. The regimen of acupuncture-moxibustion is determined by the symptoms and 
   electroacupuncture is the main measure of treatment. CONCLUSION: 
   Acupuncture-moxibustion is quite extensively involved in the treatment of tumor 
   in the field of nervous (mental) system and digestive system. But the regimen of 
   acupuncture- moxibustion needs to be further optimized and promoted.
C1 Key Laboratory of Acupuncture and Medicine Education Division, Nanjing University of CM, Nanjing 210023, Jiangsu Province, China
   Meical College/HolisticIntegrative Medical College, Nanjing University of CM, Nanjing 210023, JiangsuProvince.
   Key Laboratory of Acupuncture and Medicine Education Division, Nanjing University of CM, Nanjing 210023, Jiangsu Province, China
   Meical College/HolisticIntegrative Medical College, Nanjing University of CM, Nanjing 210023, JiangsuProvince.
   Key Laboratory of Acupuncture and Medicine Education Division, Nanjing University of CM, Nanjing 210023, Jiangsu Province, China
   Meical College/HolisticIntegrative Medical College, Nanjing University of CM, Nanjing 210023, JiangsuProvince.
   Key Laboratory of Acupuncture and Medicine Education Division, Nanjing University of CM, Nanjing 210023, Jiangsu Province, China.
   Key Laboratory of Acupuncture and Medicine Education Division, Nanjing University of CM, Nanjing 210023, Jiangsu Province, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD FEB 10
PY 2021
VL 41
IS 1
BP 111
EP 4
DI 10.13703/j.0255-2930.20191125-0007 
PG -107
WC Acupuncture Therapy; Bibliometrics; China; Humans; Moxibustion; PubMed
UT PubMed:33559454
PM 33559454
DA 2021-02-10
ER

PT J
AU Mahfudh, SS
AF Mahfudh, Salma Said
TI Nurse's role in controlling cancer pain.
SO Journal of pediatric hematology/oncology
LA English
DT Journal Article
AB Nurses spend more time with patients than any other member of the healthcare 
   team. They play a critical, active and very important part in controlling cancer 
   patients' pain and alleviating suffering. In controlling cancer pain the nurse 
   needs to understand the psychological state of the cancer patient, cancer pain, 
   cancer pain treatment, deleterious effects of unrelieved cancer pain and 
   patient's socio cultural background. She needs to understand that there are two 
   types of pain, nociceptive and neuropathic pains and that 80% of the cancer 
   patients in pain could have 2 or more than 4 different pains at the same time. 
   Nurses' role in controlling cancer pain include believing the patient, assessing 
   pain, identifying the root of the problem, planning the care, administering 
   medication, evaluating effectiveness, ensuring good pain control and 
   individualizing treatment. It also includes nursing interventions such as giving 
   tender nursing care, preventing pain, educating, advocating, communicating, 
   comforting, supporting, and counseling the patient. The nurse must use both 
   pharmacological and non pharmacological treatments to individualize treatment, 
   know all the drugs that are used for the treatment of Cancer Pain, how these 
   drugs relieve pain and what their side effects are. She must use the WHO 
   guidelines to treat pain and must choose the right drug, right dose, given at the 
   right times, with the right intervals and to the right patient. She must evaluate 
   effectiveness of treatment, give PRN doses for breakthrough pain and recommend 
   for specific changes. The role of the nurse is to anticipate the patient's pain 
   needs, advocate for the patient for what feels appropriate for him within his 
   cultural context and incorporate the patient's belief. The nurse can physically 
   relieve pain by promoting comfort, support painful area, gentleness in handling 
   the patient and use nursing treatments. The nurse can recommend physiotherapy, 
   (TENS)/Acupuncture, Occupational therapy, spiritual support, social worker, 
   psychologist, and psychiatrist to address different types of pain. She must 
   relieve both pain and other symptoms. and ensure that the patient has good sleep. 
   She must show kindness, compassion and empathize with him. Each patient is unique 
   the process of controlling cancer pain develops differently each time. The 
   nurse's role is challenging, she must demonstrate that she is not only clinically 
   proficient but culturally competent. She has to use creative assessment skills, 
   clinical judgment, psychological support, advocacy and good communication skills 
   in such a way that the contribution of drugs, nursing care, nursing and other non 
   pharmacological treatments are maximized to the patient's benefit. When 
   evaluating the overall care the nurse must find out what is the total effect of 
   all approaches taken to relieve pain. Nurses can make a difference between a 
   patient who suffers until the last breath of his/her life and a patient who is 
   comfortable and dies pain free and in dignity.
C1 Obstetric and Pain Management Certificates, PO Box 9, Code 116, Mina Al Fahal, Sultanate of Oman. ssmahfudh@hotmail.com
NR 0
TC 0
SN 1536-367
EI 
J9 J Pediatr Hematol Oncol
PD OCT 5
PY 2011
VL 33 Suppl 2
IS 
BP S146
EP 8
DI 10.1097/MPH.0b013e318230dfd8 
PG 1
WC Humans; Neoplasms; complications; Nurse's Role; Nurse-Patient Relations; Nursing Assessment; methods; Oncology Nursing; methods; Pain; etiology; Pain Management
UT PubMed:21952573
PM 21952573
DA 2011-10-05
ER

PT J
AU Giron, PS
   Haddad, CA
   Rizzi, SKLA
   Elias, S
   Nazario, ACP
   Facina, G
AF Giron, Patricia Santolia
   Haddad, Cinira Assad
   Rizzi, Samantha Karlla Lopes De Almeida
   Elias, Simone
   Nazario, Afonso Celso Pinto
   Facina, Gil
TI Exercise Therapy, Systemic Acupuncture and Silicon Oxide Tablets in the 
SO Asian Pacific journal of cancer prevention : APJCP
LA English
DT Journal Article
DE Pain; Post Breast Cancer Surgery; Range of Motion; Rehabilitation; depression
AB OBJECTIVE: To compare three rehabilitation treatments, exercise therapy, 
   acupuncture, and silicon oxide tablets (Stiper®), in women undergoing breast 
   cancer surgery, assessing pain, depression, upper limb function, and range of 
   motion parameters (ROM). METHODS: Seventy-nine women with pain above 3 on the 
   visual analog pain scale (VAS) were divided into three groups: exercise group was 
   treated with exercise therapy, acupuncture group was treated with acupuncture, 
   and Stiper® group was treated with silicon oxide tablets in place of needles. 
   RESULTS: Sixty-seven patients completed the treatment, 26 from exercise group, 23 
   from acupuncture group, and 18 from Stiper® group . There was an improvement of 
   pain over time in all groups, the first session compared with the fifth (p < 
   0.001) and with the tenth (p < 0.001), but not between groups. There was a 
   statistically significant difference in depressive symptoms using the Beck 
   questionnaire over time in the three groups, between the first and tenth sessions 
   (p = 0.001), between the first and fifth sessions (p = 0.052), but not between 
   groups. Regarding the DASH questionnaire for shoulder function, there were 
   significant differences over time at all evaluated moments (p<0.001), but not 
   between groups. There was a statistically significant difference in ROM over time 
   in the three groups, but not between groups. CONCLUSION: The rehabilitation of 
   physical dysfunctions in women who survived breast cancer through exercise 
   therapy, acupuncture, and silicon oxide tablets in pain, depression, upper limb 
   function, and ROM, proved to be effective, without statistical difference between 
   the groups.
C1 Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
NR 0
TC 0
SN 2476-762
EI 1513-736
J9 Asian Pac J Cancer Prev
PD MAR 29
PY 2025
VL 26
IS 3
BP 809
EP 817
DI 10.31557/APJCP.2025.26.3.809 
PG 8
WC Humans; Female; Breast Neoplasms; rehabilitation; Middle Aged; Acupuncture Therapy; methods; Exercise Therapy; methods; Cancer Survivors; Tablets; Range of Motion, Articular; Adult; Follow-Up Studies; Prognosis; Aged
UT PubMed:40156397
PM 40156397
DA 2025-03-29
ER

PT J
AU Butkovic, D
   Tot, OK
AF Butkovic, D
   Tot, O K
TI Laser acupuncture treatment of neuropathic pain in a boy with brain tumour.
SO Complementary therapies in medicine
LA English
DT Journal Article
DE Brain tumour; Laser acupuncture; Linezolid; Neuropathic pain; Paediatric
AB Neuropathic pain occurrence is associated with some cytostatic and antibiotics 
   use. Pharmacological therapy for the treatment of neuropathic pain is sometimes 
   unsuccessful, and complementary methods like acupuncture are included. In this 
   case report, a 14-year-old boy with cerebral tumour and neuropathic pain in his 
   feet after chemotherapy and linezolid use is presented. A complete cessation of 
   neuropathic pain symptoms like hyperalgesia and allodynia was accomplished after 
   laser acupuncture application.
C1 University of Osijek Medical School, Croatia
   Children's Hospital Zagreb, Paediatric Pain Clinic, Croatia. 
   University of Osijek Medical School, Croatia
   Clinical Hospital Centre Osijek, Department for Pain Therapy, Croatia.
EM diana.butkovic1@gmail.com
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD NOV 21
PY 2017
VL 35
IS 
BP 53
EP 56
DI 10.1016/j.ctim.2017.09.006 
PG 3
WC Acupuncture Therapy; methods; Adolescent; Brain Neoplasms; complications; Humans; Hyperalgesia; therapy; Lasers; Male; Neuralgia; etiology
UT PubMed:29154067
PM 29154067
DA 2017-11-21
ER

PT J
AU Yang, JL
   Shi, JJ
   Ma, NQ
   Jiang, MJ
   Peng, R
   Chen, LY
   Yu, ML
   Lu, SF
AF Yang, Jia-Li
   Shi, Jun-Jing
   Ma, Nai-Qi
   Jiang, Min-Jiao
   Peng, Rou
   Chen, Li-Yao
   Yu, Mei-Ling
   Lu, Sheng-Feng
TI Effect of electroacupuncture on inflammatory response and immune cells in mice 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Analgesia; Anti-inflammation; Chronic inflammatory pain; Electroacupuncture; Immune cells; Macrophage polarization
AB OBJECTIVES: To observe the effects of electroacupuncture(EA) on local 
   inflammatory mediators and macrophage polarization, and immune cells in the 
   spleen of mice with chronic inflammatory pain induced by complete Freund's 
   adjuvant (CFA) in the hind paw, so as to investigate the immunoinflammatory 
   regulatory mechanisms of EA in relieving pain and swelling in mice with chronic 
   inflammatory pain. METHODS: Thirty C57BL/6 mice were randomly divided into 
   control, model, and EA groups, with 10 mice in each group. Chronic inflammatory 
   pain model were established by subcutaneous injection of 20 μL CFA solution in 
   the left hind paw for 7 consecutive days. After modeling, mice in the EA group 
   received EA at bilateral "Zusanli"(ST36) for 20 min (2 Hz/100 Hz, 1 mA) once a 
   day for 18 consecutive days. Mechanical pain threshold, heat pain thresholds, and 
   paw thickness were measured before and after mode-ling, and after interventions. 
   Western blot was used to detect the expression of tumor necrosis factor-alpha 
   (TNF-α), interleukin (IL)-1β, and NOD-like receptor protein 3 (NLRP3) in the paw 
   tissue. Immunohistochemistry was used to detect the positive expression of 
   M1-type macrophage marker inducible nitric oride synthase (iNOS) and M2-type 
   marker CD206 in the paw, and flow cytometry was used to detect the proportion of 
   F4/80(+) CD11b(+) macrophages, Ly6G(+) CD11b(+) neutrophils, and CD25(+) Foxp3(+) 
   regulatory T cells (Treg) in the spleen. RESULTS: Compared with the control 
   group, mechanical pain and heat pain thresholds were significantly 
   reduced(P<0.000 1), while paw thickness, expressions of IL-1β, TNF-α, and NLRP3 
   in the paw, and positive expression of M1 macrophage marker iNOS in the paw, the 
   proportions of macrophages and neutrophils in the spleen were significantly 
   increased (P<0.000 1, P<0.001) in the model group. Compared with the model group, 
   mechanical pain threshold and heat pain thresholds, CD206 positive expression in 
   the paw, and Treg cell proportion in spleen were significantly increased 
   (P<0.01), while paw thickness, the expressions of IL-1β, TNF-α and NLRP3 in the 
   paw, as well as the positive expression of M1 macrophage marker iNOS in the paw, 
   the proportions of macrophages and neutrophils in the spleen were significantly 
   reduced (P<0.001, P<0.01, P<0.05)in mice of the EA group after intervention. 
   CONCLUSIONS: EA may alleviate pain and swelling in mice with chronic inflammatory 
   pain by regulating the numbers of macrophages, neutrophils, and Treg cells, as 
   well as promoting M2 polarization of local macrophages and inhibiting the release 
   of pro-inflammatory cytokines.
C1 Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang 215600, Jiangsu Province.
   Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.lushengfeng@njucm.edu.cn.
   School of Elderly Care Services and Management, Nanjing University of Chinese 
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JAN 19
PY 2024
VL 49
IS 1
BP 30
EP 36
DI 10.13702/j.1000-0607.20221174 
PG 6
WC Mice; Animals; Electroacupuncture; Tumor Necrosis Factor-alpha; genetics; NLR Family, Pyrin Domain-Containing 3 Protein; Mice, Inbred C57BL; Chronic Pain; genetics; Interleukin-1beta; Freund's Adjuvant
UT PubMed:38239136
PM 38239136
DA 2024-01-19
ER

PT J
AU Tao, F
   Hao, Y
   Wang, D
   Zhang, W
   Wang, F
AF Tao, Fan
   Hao, Yaming
   Wang, Dan
   Zhang, Weichen
   Wang, Feng
TI Clinical application and effect evaluation of acupoint thread embedding therapy 
SO Medicine
LA English
DT Journal Article
AB To evaluate the effectiveness of the combination of acupoint embedding therapy 
   and traditional Chinese medicine dialectical treatment regimen in improving 
   clinical symptoms, promoting tumor regression, controlling adverse reactions and 
   complications, and enhancing patient satisfaction by comparing and analyzing the 
   clinical data of 120 breast tumor patients. One hundred twenty patients with 
   breast cancer were divided into a treatment group (60 cases) and a control group 
   (60 cases) according to different treatment plans. Patients in the treatment 
   group received a combination of acupoint embedding therapy and traditional 
   Chinese medicine dialectical treatment based on different time points of the 
   menstrual cycle. Including the proportion of reduction in the number of breast 
   masses, the proportion of reduction in mass size, changes in pain severity 
   scores, tumor regression rate, regression time, incidence of adverse reactions 
   and complications, and patient satisfaction. Statistical software was used to 
   analyze the data to evaluate differences between the 2 groups. In terms of 
   clinical symptoms, the proportion of reduction in the number of breast masses in 
   the treatment group averaged 50%, significantly higher than the 25% in the 
   control group; the proportion of reduction in mass size averaged 40%, also higher 
   than the 15% in the control group; and the improvement in pain severity scores 
   was also superior to the control group. Regarding tumor regression, the tumor 
   regression rate in the treatment group reached 85%, with an average regression 
   time of 6.2 weeks, both significantly better than the 55% and 9.8 weeks in the 
   control group. In terms of adverse reactions and complications, the incidence 
   rate in the treatment group was relatively low, and no serious adverse events 
   occurred. Patient satisfaction surveys showed that the treatment group had 
   significantly higher satisfaction with treatment effectiveness, treatment 
   process, and physician service attitude compared to the control group. Based on 
   clinical data from 120 breast tumor patients, the results of this study indicate 
   that breast tumor patients treated with a specific treatment regimen have 
   significant advantages in improving clinical symptoms, tumor regression, 
   controlling adverse reactions and complications, and patient satisfaction. This 
   treatment regimen has high clinical application value and deserves further 
   promotion.
C1 Department of Traditional Chinese Medicine, Wuhan Fifth Hospital, Wuhan, Hubei, China.
   Department of Traditional Chinese Medicine, Wuhan Fifth Hospital, Wuhan, Hubei, China.
   Department of Traditional Chinese Medicine, Wuhan Fifth Hospital, Wuhan, Hubei, China.
   Department of Traditional Chinese Medicine, Wuhan Fifth Hospital, Wuhan, Hubei, China.
   School of Physical Education, Wuhan Business University, Wuhan, Hubei, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JUN 28
PY 2024
VL 103
IS 26
BP e38502
EP e38502
DI 10.1097/MD.0000000000038502 
PG 1
WC Humans; Female; Adult; Middle Aged; Medicine, Chinese Traditional; methods; Breast Neoplasms; therapy; Patient Satisfaction; Acupuncture Points; Menstrual Cycle; Hyperplasia; Acupuncture Therapy; methods; Treatment Outcome; Breast; pathology; Combined Modality Therapy
UT PubMed:38941407
PM 38941407
DA 2024-06-28
ER

PT J
AU Zhou, P
   Zhang, C
   Zhou, M
   Fu, J
   He, J
   Sun, N
   Cao, W
AF Zhou, Panli
   Zhang, Caiju
   Zhou, Mintao
   Fu, Jinhou
   He, Jinqian
   Sun, Ning
   Cao, Weifu
TI [Effect of electroacupuncture pretreatment on the quality of recovery in the 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE electroacupuncture; gastrointestinal tumor surgery; laparoscope; quality of recovery; randomized controlled trial (RCT)
AB OBJECTIVE: To investigate the effect of electroacupuncture pretreatment on the 
   quality of recovery in the patients undergoing laparoscopic gastrointestinal 
   surgery. METHODS: Sixty patients for elective laparoscopic resection of 
   gastrointestinal tumors under general anesthesia were randomly assigned to either 
   an observation group or a control group, with 30 patients in each group. In the 
   control group, the routine inhalation-intravenous combined general anesthesia was 
   adopted. On the basis of the control group, in the observation group, 30 min 
   before anesthesia induction, electroacupuncture was applied to bilateral Neiguan 
   (PC 6) and Neimadian (Extra) for 30 min, using disperse-dense wave and at 2 
   Hz/100 Hz. The recovery time of spontaneous breathing, awakening time, extubation 
   time, and the post-anesthesia care unit (PACU) stay time were compared between 
   the two groups. Mean arterial pressure (MAP), heart rate (HR), and oxygen 
   saturation (SpO(2)) were recorded at multiple time points: before 
   electroacupuncture (T0), before extubation (T1), immediately after extubation 
   (T2), 5 minutes (T3) and 10 minutes (T4) after extubation, and upon discharge 
   from PACU (T5). The visual analogue scale (VAS) score for pain and Ramsay 
   sedation score at T3, T4 and T5 were observed; and the incidence of agitation, 
   nausea and vomiting at T5 was evaluated in the two groups. At T0 and T5, the 
   serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and 
   cortisol were determined in the two groups. RESULTS: In the observation group, 
   the recovery time of spontaneous breathing, awakening time, extubation time, and 
   PACU stay time were shorter (P<0.001), MAP and HR at T2 were lower (P<0.01, 
   P<0.05), the VAS scores for pain at T3, T4, and T5 dropped (P<0.001, P<0.01), and 
   the Ramsay sedation score at T3 reduced (P<0.05) compared with those in the 
   control group. The incidence of nausea and vomiting was lower in the observation 
   group when compared with that in the control group (P<0.05). In comparison with 
   the indexes at T0, the serum levels of TNF-α, IL-6, and cortisol increased at T5 
   in both groups (P<0.01); and these indexes at T5 in the observation group were 
   lower than those in the control group (P<0.01, P<0.05). CONCLUSION: 
   Electroacupuncture pretreatment can enhance the quality of recovery in the 
   patients undergoing laparoscopic gastrointestinal tumor surgery, shorten the time 
   for spontaneous breathing recovery, awakening, extubation and PACU stay, and 
   attenuate postoperative pain and stress response.
C1 Department of Anesthesiology, First People's Hospital of Nanyang City Affiliated to Henan University, Nanyang 473010, China.
   Department of Anesthesiology, First People's Hospital of Nanyang City Affiliated to Henan University, Nanyang 473010, China.
   Department of Anesthesiology, First People's Hospital of Nanyang City Affiliated to Henan University, Nanyang 473010, China.
   Department of Anesthesiology, First People's Hospital of Nanyang City Affiliated to Henan University, Nanyang 473010, China.
   Department of Anesthesiology, First People's Hospital of Nanyang City Affiliated to Henan University, Nanyang 473010, China.
   Department of Anesthesiology, First People's Hospital of Nanyang City Affiliated to Henan University, Nanyang 473010, China.
   Department of Anesthesiology, First People's Hospital of Nanyang City Affiliated to Henan University, Nanyang 473010, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD DEC 11
PY 2024
VL 44
IS 12
BP 1377
EP 82
DI 10.13703/j.0255-2930.20240223-k0001 
PG -1295
WC Humans; Electroacupuncture; Female; Male; Middle Aged; Laparoscopy; Adult; Aged; Anesthesia Recovery Period; Interleukin-6; blood; Pain, Postoperative; therapy; Tumor Necrosis Factor-alpha; blood; Young Adult; Gastrointestinal Neoplasms; surgery; Acupuncture Analgesia
UT PubMed:39658374
PM 39658374
DA 2024-12-11
ER

PT J
AU Sun, L
   Wei, X
   Feng, T
   Gu, Q
   Li, J
   Wang, K
   Zhou, J
AF Sun, Linxi
   Wei, Xuqiang
   Feng, Tienan
   Gu, Qunhao
   Li, Jing
   Wang, Ke
   Zhou, Jia
TI Electroacupuncture promotes gastrointestinal functional recovery after radical 
SO International journal of colorectal disease
LA English
DT Journal Article
DE Colorectal cancer surgery; Electroacupuncture; Enhanced Recovery After Surgery; Gastrointestinal functional recovery; Protocol; Randomized controlled trial
AB INTRODUCTION: The incidence of postoperative gastrointestinal dysfunction (POGD) 
   is notably high among patients following colorectal cancer surgery, highlighting 
   the urgency for the prompt development of efficacious preventive and therapeutic 
   approaches. Electroacupuncture (EA) represents an intervention modality that 
   holds promise for the management of POGD. However, the existing empirical 
   evidence substantiating its efficacy remains scarce. The aim of this study is to 
   evaluate the efficacy and safety of EA as a treatment for POGD in patients 
   undergoing colorectal cancer surgery. METHODS: This study is a multicenter, 
   parallel-group, randomized controlled trial, named as CORRECT. CORRECT trial will 
   recruit 300 participants diagnosed with colorectal cancer and about to undergo 
   radical surgery across four sub-centers. The participants will be randomly 
   assigned to one of three groups: the EA group, sham-electroacupuncture group, or 
   control group, with a randomization ratio of 2:2:1. All groups will follow a 
   standardized Enhanced Recovery After Surgery (ERAS) protocol. The EA group will 
   receive EA at acupoints LI4, SJ6, ST36, and ST37, while the SA group will undergo 
   sham-electroacupuncture. The treatments will be administered twice daily from the 
   day of surgery until the fourth day after the operation. The primary endpoint is 
   the time to first flatus, while secondary endpoints encompass time to first 
   defecation, bowel sound emergence, initial water intake, duration of 
   postoperative hospitalization, nausea and vomiting, pain levels, and blinded 
   evaluations. Additional outcomes include medication usage and complication rates, 
   et al. DISCUSSION: The CORRECT trial aims to provide high-quality evidence for 
   the role of EA in the treatment of POGD following colorectal cancer surgery. It 
   will contribute data towards the integration of acupuncture into ERAS protocols. 
   Insights from the trial could help in tailoring treatment plans based on 
   individual patient responses to EA, optimizing care on a case-by-case basis. 
   TRIAL REGISTRATION: Clinical Trial Registry registration was approved by the 
   ClinicalTrials.gov committee on November 2023 with the ClinicalTrials.gov 
   Identifier: NCT06128785. URL: 
   https://clinicaltrials.gov/study/NCT06128785?tab=history&a=1#study-details-card .
C1 Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, People's Republic of China.
   Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, People's Republic of China.
   Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, 227# South Chongqing Road, Xuhui, Shanghai, 200025, China.
   Gastrointestinal Surgery Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional ChineseMedicine, Shanghai, People's Republic of China.
   Department of Acupuncture and Moxibustion II, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TraditionalChinese Medicine, Shanghai, People's Republic of China.
   Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, People's Republic of China.wangke8430@163.com.
   Office of National Clinical Research Base of TCM, Yueyang Hospital of Integrated 
   Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, People's Republic of China.pdzhoujia@163.com.
   Office of National Clinical Research Base of TCM, Yueyang Hospital of Integrated 
NR 0
TC 0
SN 1432-126
EI 0179-195
J9 Int J Colorectal Dis
PD DEC 9
PY 2024
VL 39
IS 1
BP 198
EP 198
DI 10.1007/s00384-024-04768-8 
PG 0
WC Female; Humans; Male; Middle Aged; Colorectal Neoplasms; surgery; Electroacupuncture; Postoperative Complications; etiology; Randomized Controlled Trials as Topic; Recovery of Function; Treatment Outcome
UT PubMed:39652211
PM 39652211
DA 2024-12-09
ER

PT J
AU Giron, PS
   Haddad, CAS
   Lopes, De Almeida Rizzi SK
   Elias, S
   Nazário, ACP
   Facina, G
AF Giron, Patricia Santolia
   Haddad, Cinira Assad Simão
   Lopes De Almeida Rizzi, Samantha Karlla
   Elias, Simone
   Nazário, Afonso Celso Pinto
   Facina, Gil
TI Effect of Exercise Therapy, Systemic Acupuncture and Silicon Oxide Tablets on 
SO Asian Pacific journal of cancer prevention : APJCP
LA English
DT Journal Article
DE Acupuncture; Lymphedema; Quality of Life; Rehabilitation; muscle strength
AB OBJECTIVE: The purpose of this study was to compare the effectiveness of three 
   different rehabilitation treatments (exercise therapy, acupuncture, and silicon 
   oxide tablets (Stiper®) in women who have undergone breast cancer surgery. The 
   study assessed the impact of these treatments on strength, lymphedema, and 
   quality of life. METHODS: The study included seventy-nine women who reported pain 
   levels above 3 on the visual analog pain scale (VAS) and had undergone surgery 
   more than 90 days prior. Group I received exercise therapy for 30 minutes, Group 
   II received acupuncture for 30 minutes using predefined points, and Group III 
   received acupuncture at the same points as Group II using silicon oxide instead 
   of needles at the same points as Group II. RESULTS: The results showed an 
   improvement in upper limb muscle strength over time in all groups, except for 
   abduction and internal rotation movements. During treatment, there was no 
   increase in the number of patients with lymphedema, and there was no statistical 
   difference between the groups. Nine out of the fifteen factors analyzed in the 
   EORTC QLQ-C30 quality of life questionnaire showed significant differences 
   between sessions. The factors that did not show significant differences between 
   the three groups were Social Function, Nausea and Vomiting, Dyspnea, Loss of 
   Appetite, Constipation, and Diarrhea. CONCLUSION: The rehabilitation of physical 
   dysfunctions in women who survived breast cancer through exercise therapy, 
   acupuncture, and silicon oxide tablets in upper limb muscle strength, lymphedema, 
   and quality of life, proved to be effective, without difference between groups.
C1 Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
   Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
NR 0
TC 0
SN 2476-762
EI 1513-736
J9 Asian Pac J Cancer Prev
PD MAR 29
PY 2025
VL 26
IS 3
BP 799
EP 808
DI 10.31557/APJCP.2025.26.3.799 
PG 9
WC Humans; Female; Quality of Life; Breast Neoplasms; rehabilitation; Muscle Strength; Middle Aged; Acupuncture Therapy; methods; Exercise Therapy; methods; Cancer Survivors; Lymphedema; etiology; Adult; Follow-Up Studies; Tablets; Prognosis; Aged
UT PubMed:40156396
PM 40156396
DA 2025-03-29
ER

PT J
AU Paley, CA
   Johnson, MI
AF Paley, Carole A
   Johnson, Mark I
TI Acupuncture for the management of cancer-related pain?
SO Pain management
LA English
DT Journal Article
DE acupuncture; cancer; pain
C1 Centre for Pain Research, School of Clinical & Applied Sciences, Leeds Beckett University, City Campus, Leeds LS1 3HE, UK.
   Research & Development Department, Airedale NHS Foundation Trust, Skipton Road, 
   Centre for Pain Research, School of Clinical & Applied Sciences, Leeds Beckett University, City Campus, Leeds LS1 3HE, UK.
NR 0
TC 0
SN 1758-187
EI 
J9 Pain Manag
PD SEP 25
PY 2017
VL 7
IS 5
BP 345
EP 349
DI 10.2217/pmt-2017-0018 
PG 4
WC Acupuncture Therapy; Cancer Pain; therapy; Humans; Pain Management; methods; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:28936907
PM 28936907
DA 2017-09-25
ER

PT J
AU Zhang, RY
   Zhu, BF
   Wang, LK
   Song, Y
   Zhao, JG
   Guo, Y
   Zhao, L
   Chen, S
AF Zhang, Rong Yi
   Zhu, Ben Fan
   Wang, Li Kui
   Song, Yang
   Zhao, Jia Gui
   Guo, Yan
   Zhao, Long
   Chen, Shi
TI Electroacupuncture alleviates inflammatory pain via adenosine suppression and its 
SO Arquivos de neuro-psiquiatria
LA English
DT Journal Article
AB BACKGROUND: Acupuncture has been widely used for alleviating pain. However, its 
   mechanisms remain largely enigmatic. OBJECTIVE: In the present study, we focused 
   on whether the analgesic effect of electroacupuncture is related to its 
   regulation on adenosine and substance P expression. METHODS: We established 
   chronic inflammatory pain model in rats through a single injection of Complete 
   Freund's Adjuvant, and then we treated animals using daily electroacupuncture. We 
   applied seven bilateral sessions of electroacupuncture (ST36 and BL60, 0.5 to 1.5 
   mA, initial strength of 0.5 mA, increased by 0.5 mA every 10 minutes, for 30 
   minutes per session, one section per day) to Complete Freund's Adjuvant rats for 
   seven days. The analgesic effect of electroacupuncture was evaluated by measuring 
   paw withdrawal threshold in rats that received mechanical and thermal 
   stimulation. RESULTS: Daily electroacupuncture stimulation effectively increased 
   paw withdrawal threshold in Complete Freund's Adjuvant rats. Electroacupuncture 
   increased the adenosine level in zusanli. A further study showed that 
   electroacupuncture could decrease substance P, neurokinin-1 receptor, tumor 
   necrosis factor-alpha, interleukin-1β, interleukin-6 and CD68 levels in dorsal 
   root ganglion. Interestingly, direct injection of adenosine A1 or substance P 
   receptor antagonists, or dorsal nerve root transection could significantly impair 
   electroacupuncture induced analgesic actions in Complete Freund's Adjuvant rats 
   could and reduce the levels of substance P, neurokinin-1 receptor, tumor necrosis 
   factor-alpha, interleukin-1β, interleukin-6 and CD68. Finally, we confirmed that 
   direct injection of adenosine A1 receptor agonist replicated the analgesic effect 
   of electroacupuncture. CONCLUSION: Our results indicate regulation of 
   adenosine-mediated substance P secretion. Substance P-mediated pathway may be 
   involved in the analgesia process by electroacupuncture in rats.
C1 Anhui Medical University, The First Affiliated Hospital, Department of Pain Management, Hefei, Anhui Province, China.
   Anhui Medical University, The First Affiliated Hospital, Department of Pain Management, Hefei, Anhui Province, China.
   Anhui Medical University, The First Affiliated Hospital, Department of Pain Management, Hefei, Anhui Province, China.
   Anhui Medical University, The First Affiliated Hospital, Department of Pain Management, Hefei, Anhui Province, China.
   Anhui Medical University, The First Affiliated Hospital, Department of Pain Management, Hefei, Anhui Province, China.
   Anhui Medical University, The First Affiliated Hospital, Department of Pain Management, Hefei, Anhui Province, China.
   Anhui Medical University, The First Affiliated Hospital, Department of Pain Management, Hefei, Anhui Province, China.
   Anhui Medical University, The First Affiliated Hospital, Department of Pain Management, Hefei, Anhui Province, China.
NR 0
TC 0
SN 1678-422
EI 
J9 Arq Neuropsiquiatr
PD NOV 5
PY 2020
VL 78
IS 10
BP 617
EP 623
DI 10.1590/0004-282X20200078 
PG 6
WC Adenosine; chemistry; Animals; Electroacupuncture; Pain; Rats; Rats, Sprague-Dawley; Substance P; chemistry
UT PubMed:33146290
PM 33146290
DA 2020-11-05
ER

PT J
AU Mandıroğlu, S
   Cevik, C
   Aylı, M
AF Mandıroğlu, Sibel
   Cevik, Cemal
   Aylı, Meltem
TI Acupuncture for neuropathic pain due to bortezomib in a patient with multiple 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE Acupuncture
AB Multiple myeloma (MM) is characterised by an increase in plasma cells, 
   particularly in the bone marrow but also in other organs and systems, and with 
   the abnormal production of immunoglobulin. Bortezomib, a current treatment 
   option, inhibits angiogenesis by proteasome inhibition and is known to be 
   effective in the treatment of MM. Peripheral neuropathy (PN) is a common 
   dose-related side effect of bortezomib in patients with MM. We describe a case of 
   PN due to bortezomib treatment which responded dramatically to acupuncture 
   treatment, enabling his bortezomib treatment to continue. The patient was a 
   74-year-old man with pain, numbness, tingling and weakness in his hands and feet 
   after 22 days of bortezomib treatment given by the haematology clinic. His 
   neuropathic pain score was 8/10. There were no autonomic symptoms. 
   Electroneurophysiological testing confirmed sensorimotor PN. Acupuncture 
   treatment was planned as his neuropathic pain continued. Acupuncture was 
   administered bilaterally to ST36, SP6 and LI4 15 times (every other day in the 
   first five sessions and then twice a week). The numbness, tingling and pain 
   symptoms substantially decreased after the first two treatments. After the 15th 
   session acupuncture treatment was continued once a month. At the end of the sixth 
   month the neuropathic pain assessment score was 0/10. There was no side effect of 
   acupuncture treatment. Acupuncture seems promising as a complementary medical 
   treatment for neuropathic pain from bortezomib-induced PN. Clinical studies 
   involving more cases and electrophysiological studies are necessary to 
   investigate the effectiveness of acupuncture.
C1 Department of Physical Medicine and Rehabilitation, Ankara Physical Medicine and Rehabilitation Training and Research Hospital, , Ankara, Turkey.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD JAN 7
PY 2014
VL 32
IS 2
BP 194
EP 6
DI 10.1136/acupmed-2013-010491 
PG -188
WC Acupuncture Therapy; Aged; Boronic Acids; adverse effects; Bortezomib; Humans; Male; Multiple Myeloma; drug therapy; Neuralgia; chemically induced; Pyrazines; adverse effects
UT PubMed:24389811
PM 24389811
DA 2014-01-07
ER

PT J
AU Santillan-Garcia, A
   Moran, JM
AF Santillan-Garcia, Azucena
   Moran, J M
TI Statistical Concerns About Acupressure on Pain in Cancer Patients With Bone 
SO Integrative cancer therapies
LA English
DT Letter
C1 1 Hospital Universitario de Burgos, Burgos, Spain.
   2 Universidad Extremadura, Cáceres, Spain.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD FEB 23
PY 2019
VL 18
IS 
BP 1534735419827087
EP 1534735419827087
DI 10.1177/1534735419827087 
PG 1
WC Acupressure; Bone Neoplasms; Cancer Pain; Humans; Pain; Pain Management
UT PubMed:30791737
PM 30791737
DA 2019-02-23
ER

PT J
AU Grant, SJ
   Kwon, K
   Naehrig, D
   Asher, R
   Lacey, J
AF Grant, Suzanne J
   Kwon, Ki
   Naehrig, Diana
   Asher, Rebecca
   Lacey, Judith
TI Characteristics and Symptom Burden of Patients Accessing Acupuncture Services at 
SO Integrative cancer therapies
LA English
DT Journal Article
DE ESAS; acupuncture; cancer; integrative oncology; patient report outcome measures; symptom clusters
AB BACKGROUND: Patients with cancer are often impacted by a significant symptom 
   burden. Cancer hospitals increasingly recognize the value of complementary and 
   integrative therapies to support the management of cancer related symptoms. The 
   aim of this study is to provide a better understanding of the demographic 
   characteristics and symptoms experienced by cancer patients who access 
   acupuncture services in a tertiary hospital in Australia. METHODS: A 
   retrospective audit was conducted of patients that presented to the acupuncture 
   service at Chris O'Brien Lifehouse between July 2017 and December 2018. Edmonton 
   Symptom Assessment Scale (ESAS) and Measure Yourself Concerns and Wellbeing 
   (MYCaW) outcome measures were used. The quantitative data was analyzed using 
   descriptive statistics and Principal Component Analysis. RESULTS: A total of 127 
   inpatients and outpatients (mean age 55, range 19-85) were included with 441 
   individual surveys completed (264 ESAS, 177 MYCaW). Patients were predominantly 
   female (76.8%) and breast cancer was the most prevalent primary diagnosis (48%). 
   The most prevalent symptoms in the ESAS were sleep problems (88.6%), fatigue 
   (88.3%), lack of wellbeing (88.1%), and memory difficulty (82.6%). Similarly, 
   symptoms with the highest mean scores were numbness, fatigue, sleep problems and 
   hot flushes, whilst neuropathy, and hot flashes were scored as the most severe 
   (score ≥7) by patients. Cluster analysis yielded 3 symptom clusters, 2 included 
   "physical symptoms" (pain, sleep problems, fatigue and numbness/neuropathy), and 
   (nausea, appetite, general well-being), whilst the third included "psychological" 
   symptoms (anxiety, depression, spiritual pain, financial distress). The most 
   frequent concerns expressed by patients (MyCaW) seeking acupuncture were side 
   effects of chemotherapy (24.6%) and pain (20.8%). CONCLUSION: This audit 
   highlights the most prevalent symptoms, the symptoms with the greatest burden and 
   the types of patients that receive acupuncture services at an Australian tertiary 
   hospital setting. The findings of this audit provide direction for future 
   acupuncture practices and research in hospital settings.
C1 NICM Health Research Institute, Western Sydney University, NSW, Australia.
   Chris O'Brien Comprehensive Cancer Centre, Camperdown, NSW, Australia.
   NICM Health Research Institute, Western Sydney University, NSW, Australia.
   Chris O'Brien Comprehensive Cancer Centre, Camperdown, NSW, Australia.
   University of Sydney, NSW, Australia.
   National Health Medical Research Council, Sydney, NSW, Australia.
   NICM Health Research Institute, Western Sydney University, NSW, Australia.
   Chris O'Brien Comprehensive Cancer Centre, Camperdown, NSW, Australia.
   University of Sydney, NSW, Australia.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD APR 13
PY 2021
VL 20
IS 
BP 15347354211002253
EP 15347354211002253
DI 10.1177/15347354211002253 
PG 1
WC Acupuncture Therapy; Australia; epidemiology; Breast Neoplasms; Cancer Care Facilities; Fatigue; epidemiology; Female; Humans; Middle Aged; Neoplasms; epidemiology; Retrospective Studies
UT PubMed:33840252
PM 33840252
DA 2021-04-13
ER

PT J
AU Bao, T
   Ye, X
   Skinner, J
   Cao, B
   Fisher, J
   Nesbit, S
   Grossman, SA
AF Bao, Ting
   Ye, Xiaobu
   Skinner, Janice
   Cao, Bing
   Fisher, Joy
   Nesbit, Suzanne
   Grossman, Stuart A
TI The analgesic effect of magnetic acupressure in cancer patients undergoing bone 
SO Journal of pain and symptom management
LA English
DT Journal Article
AB CONTEXT: Bone marrow aspiration and biopsy (BMAB) is a frequently performed and 
   painful procedure. OBJECTIVES: To evaluate the efficacy of magnetic acupressure 
   in reducing pain in cancer patients undergoing BMAB. METHODS: Cancer patients 
   without previous acupuncture or acupressure experience were stratified by the 
   number of prior BMAB and randomized to having magnetic acupressure delivered to 
   either the large intestine 4 (LI4) acupoint or a sham site. The primary study 
   endpoint was the patient's pain intensity rating during the procedure using a 
   visual analogue scale (VAS). RESULTS: Seventy-seven eligible patients received 
   magnetic acupressure: 37 were randomized to treatment at the LI4 site arm and 40 
   at the designated sham site arm. There was no significant difference between the 
   median pain scores of patients treated at the LI4 site and the sham site 
   (P=0.87). However, severe pain (VAS ≥ 7) was reported in only one patient (2.7%) 
   treated at the LI4 site compared with eight patients (20%) at the sham site 
   (P=0.03). No patients experienced significant magnetic acupressure-related 
   toxicities. CONCLUSION: Magnetic acupressure at the LI4 acupoint requires minimal 
   training and expense and is well tolerated. Although its use did not 
   significantly reduce median pain scores in patients undergoing BMAB, it does 
   appear to reduce the proportion of patients with severe pain associated with this 
   invasive procedure.
C1 The University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21212, USA.tingbao@gmail.com
NR 0
TC 0
SN 1873-651
EI 
J9 J Pain Symptom Manage
PD FEB 11
PY 2011
VL 41
IS 6
BP 995
EP 1002
DI 10.1016/j.jpainsymman.2010.08.012 
PG 7
WC Acupressure; methods; Biopsy, Needle; adverse effects; Bone Marrow; pathology; Female; Humans; Magnetic Field Therapy; methods; Male; Middle Aged; Neoplasms; complications; Pain; etiology; Single-Blind Method; Treatment Outcome
UT PubMed:21306863
PM 21306863
DA 2011-02-11
ER

PT J
AU Henry, NL
   Unger, JM
   Till, C
   Crew, KD
   Fisch, MJ
   Hershman, DL
AF Henry, N Lynn
   Unger, Joseph M
   Till, Cathee
   Crew, Katherine D
   Fisch, Michael J
   Hershman, Dawn L
TI Predictors of Pain Reduction in Trials of Interventions for Aromatase 
SO JNCI cancer spectrum
LA English
DT Journal Article
AB BACKGROUND: Almost one-half of aromatase inhibitor (AI)-treated breast cancer 
   patients experience AI-associated musculoskeletal symptoms (AIMSS); 20%-30% 
   discontinue treatment because of severe symptoms. We hypothesized that we could 
   identify predictors of pain reduction in AIMSS intervention trials by combining 
   data from previously conducted trials. METHODS: We pooled patient-level data from 
   3 randomized trials testing interventions (omega-3 fatty acids, acupuncture, and 
   duloxetine) for AIMSS that had similar eligibility criteria and the same 
   patient-reported outcome measures. Only patients with a baseline Brief Pain 
   Inventory average pain score of at least 4 of 10 were included. The primary 
   outcome examined was 2-point reduction in average pain from baseline to week 12. 
   Variable cut-point selection and logistic regression were used. Risk models were 
   built by summing the number of factors statistically significantly associated 
   with pain reduction. Analyses were stratified by study and adjusted for treatment 
   arm. RESULTS: For the 583 analyzed patients, the 4 factors statistically 
   significantly associated with pain reduction were Functional Assessment of Cancer 
   Therapy Functional Well-Being greater than 24 and Physical Well-Being greater 
   than 14 (higher scores reflect better function), and Western Ontario and McMaster 
   Universities Osteoarthritis Index less than 50 and Modified Score for the 
   Assessment and Quantification of Chronic Rheumatoid Affections of the Hands less 
   than 33 (lower scores reflect less pain). Patients with all 4 factors were 
   greater than 6 times more likely to experience at least a 2-point pain reduction 
   (odds ratio = 6.37, 95% confidence interval = 2.31 to 17.53, 2-sided P < .001); 
   similar results were found for secondary 30% and 50% pain reduction endpoints. 
   CONCLUSIONS: Patients with AIMSS who have lower symptom and functional distress 
   at study entry on AIMSS intervention trials are more likely to experience 
   meaningful pain reduction. Baseline symptom and functional status should be 
   considered as stratification factors in future interventional trials.
C1 Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
   SWOG Statistics and Data Management Center, Seattle, WA, USA.
   Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, 
   SWOG Statistics and Data Management Center, Seattle, WA, USA.
   Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, 
   Department of Medicine, Columbia University, New York, NY, USA.
   Department of General Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   Department of Medicine, Columbia University, New York, NY, USA.
NR 0
TC 0
SN 2515-509
EI 
J9 JNCI Cancer Spectr
PD DEC 14
PY 2021
VL 5
IS 6
BP 
EP 
DI 10.1093/jncics/pkab087 
PG 0
WC Acupuncture Analgesia; Adult; Aged; Aged, 80 and over; Analgesics; therapeutic use; Aromatase Inhibitors; adverse effects; Breast Neoplasms; drug therapy; Duloxetine Hydrochloride; therapeutic use; Fatty Acids, Omega-3; therapeutic use; Female; Humans; Logistic Models; Middle Aged; Musculoskeletal Pain; chemically induced; Pain Management; methods; Pain Measurement; drug effects; Patient Reported Outcome Measures; Randomized Controlled Trials as Topic
UT PubMed:34901744
PM 34901744
DA 2021-12-14
ER

PT J
AU Ben-Arye, E
   Gamus, D
   Samuels, N
   Schiff, E
   Hausner, D
   Gressel, O
   Attias, S
   Lavie, O
   David, A
   Shulman, K
   Agbarya, A
AF Ben-Arye, Eran
   Gamus, Dorit
   Samuels, Noah
   Schiff, Elad
   Hausner, David
   Gressel, Orit
   Attias, Samuel
   Lavie, Ofer
   David, Adi
   Shulman, Katerina
   Agbarya, Abed
TI Acupuncture and integrative oncology for taxane-induced peripheral neuropathy: a 
SO International journal of gynecological cancer : official journal of the 
LA English
DT Journal Article
DE Quality of Life (PRO)/Palliative Care
AB OBJECTIVE: To compare the effectiveness of acupuncture alone or with additional 
   integrative oncology modalities for taxane-induced peripheral neuropathy-related 
   symptoms in patients with gynecological and breast cancer. METHODS: The study was 
   a prospective evaluation of patients undergoing twice-weekly treatments with 
   either acupuncture alone (single-modality, group A) or with additional 
   manual-movement and mind-body therapies (multimodality, group B), for 6 weeks. 
   Symptom severity was assessed at baseline, 6 weeks, and 9 weeks using the 
   Functional Assessment of Cancer Therapy-Taxane (FACT-Tax) tool; and von Frey 
   perception thresholds. Additional symptoms were also assessed with the European 
   Organization for Research and Treatment of Cancer Quality of Life Questionnaire 
   (EORTC QLQ-C30) and the Measure Yourself Concerns and Wellbeing (MYCaW) study 
   tool. RESULTS: For the 120 participants (60 in each study arm), baseline to 
   6-week scores were similar in both groups for improved FACT-Tax physical 
   wellbeing and scores for hand numbness/tingling; EORTC physical functioning and 
   global health status; and MYCaW scores. FACT-Tax taxane subscales and scores for 
   foot numbness/tingling improved only in group A (p=0.038), while emotional 
   wellbeing FACT-Tax (p=0.02) and EORTC pain (p=0.005) improved only in group B. 
   Group B showed greater improvement for FACT-Tax neuropathy-related concerns than 
   group A at 24 hours (p=0.043) and 7 days (p=0.009) after the first treatment. 
   CONCLUSION: Acupuncture alone or with additional integrative oncology modalities 
   may help reduce neuropathy-related symptoms. The single-modality group 
   demonstrated greater improvement for foot numbness/tingling, and the 
   multimodality group demonstrated improvement for pain and improved emotional 
   wellbeing and neuropathy-related concerns in the first week of treatment. TRIAL 
   REGISTRATION NUMBER: NCT03290976.
C1 The Oncology Service
   Lin Medical Center, Clalit Health Services
   Haifa and Western Galilee District, Haifa, Israel eranben@netvision.net.il.
   Technion Israel Institute of Technology, Haifa, Israel.
   Sheba Medical Center, Tel Hashomer, Israel.
   Shaare Zedek Medical Center, Jerusalem, Israel.
   Technion Israel Institute of Technology, Haifa, Israel.
   Department of Internal Medicine, Hospital, Haifa, Israel.
   Bnai Zion Medical Center, Haifa, Israel.
   Sheba Medical Center, Tel Hashomer, Israel.
   The Oncology Service
   Lin Medical Center, Clalit Health Services
   Haifa and Western Galilee District, Haifa, Israel.
   Bnai Zion Medical Center, Haifa, Israel.
   Technion Israel Institute of Technology, Haifa, Israel.
   Lady Davies Carmel Medical Center, Haifa, Israel.
   Sheba Medical Center, Tel Hashomer, Israel.
   LIN Medical Center, Haifa, Israel.
   Bnai Zion Medical Center, Haifa, Israel.
NR 0
TC 0
SN 1525-143
EI 
J9 Int J Gynecol Cancer
PD JAN 6
PY 2023
VL 33
IS 5
BP 792
EP 801
DI 10.1136/ijgc-2022-004004 
PG 9
WC Humans; Integrative Oncology; Quality of Life; psychology; Hypesthesia; Acupuncture Therapy; Peripheral Nervous System Diseases; chemically induced; Taxoids; adverse effects; Pain; Surveys and Questionnaires
UT PubMed:36600535
PM 36600535
DA 2023-01-06
ER

PT J
AU Ji, L
   Han, L
   Sharma, A
AF Ji, Lei
   Han, Lin
   Sharma, Aabha
TI Efficacy of acupuncture in managing radiotherapy/chemotherapy-induced oral 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture; Cancer; Chemotherapy; Meta-analysis; Oral mucositis; Radiotherapy
AB PURPOSE: To evaluate the preventive and therapeutic efficacy of acupuncture 
   modalities in radiation/chemotherapy-induced oral mucositis (RIOM/CIOM) 
   management through evidence synthesis. METHODS: A systematic search was performed 
   in eight biomedical databases: four English-language databases (PubMed, Embase, 
   Web of Science, and Cochrane Library) and four Chinese-language databases (China 
   National Knowledge Infrastructure (CNKI), Wanfang, VIP, and SinoMed) for studies 
   published up to July 25, 2025. Randomized controlled trials (RCTs) in English or 
   Chinese investigating acupuncture for RIOM/CIOM were included. Dual independent 
   extraction with standardized forms and quality appraisal using the Cochrane RoB 
   2.0 tool were implemented. The primary outcome was OM grading according to WHO, 
   RTOG, or other recognized scales. The evidence quality was assessed using the 
   Grading of Recommendations Assessment, Development, and Evaluation (GRADE) 
   methodology. RESULTS: Eleven RCTs (n = 865) were included. Acupuncture 
   significantly reduced moderate-to-severe OM incidence [RR = 0.58, 95% 
   CI:0.45-0.76; P < 0.0001), with therapeutic interventions showing greater 
   efficacy than preventive approaches (P < 0.0001). Auricular acupuncture showed 
   substantial benefit (RR = 0.54 vs manual technique RR = 0.97). Other outcomes 
   revealed significant ulcer duration reduction (SMD = -1.13, 95% CI -1.71-[-0.55]; 
   P = 0.0001), pain score improvement (SMD = -1.89, P = 0.0005), and enhanced 
   immune modulation (TGF-β1/IL-6 levels) with Karnofsky performance increase 
   (MD = 5.83, P = 0.004). No severe adverse events were reported. The quality of 
   evidence was rated as moderate due to significant heterogeneity observed across 
   the studies. CONCLUSIONS: The systematic review and meta-analysis found that 
   acupuncture was effectively associated with preventing and treating RIOM/CIOM, 
   shortening ulcer duration, reducing ulcer size, alleviating pain, and improving 
   quality of life, although the evidence level was moderate. The finding suggests 
   that more high-quality RCTs were needed for validation.
C1 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. tjhanlin@163.com.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   Tianjin University of Traditional Chinese Medicine, Tianjin, China.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD SEP 24
PY 2025
VL 33
IS 10
BP 873
EP 873
DI 10.1007/s00520-025-09931-7 
PG 0
WC Humans; Acupuncture Therapy; methods; Antineoplastic Agents; adverse effects; Neoplasms; radiotherapy; Radiation Injuries; therapy; Randomized Controlled Trials as Topic; Stomatitis; therapy
UT PubMed:40987848
PM 40987848
DA 2025-09-24
ER

PT J
AU Yeh, CH
   Lin, WC
   Kwai-Ping, Suen L
   Park, NJ
   Wood, LJ
   van, Londen GJ
   Howard, Bovbjerg D
AF Yeh, Chao Hsing
   Lin, Wei-Chun
   Kwai-Ping Suen, Lorna
   Park, Na-Jin
   Wood, Lisa J
   van Londen, G J
   Howard Bovbjerg, Dana
TI Auricular Point Acupressure to Manage Aromatase Inhibitor-Induced Arthralgia in 
SO Oncology nursing forum
LA English
DT Journal Article
DE acupressure; aromatase inhibitor–induced arthralgia; breast cancer survivors
AB PURPOSE/OBJECTIVES: To assess the feasibility of auricular point acupressure to 
   manage aromatase inhibitor-induced arthralgia. . DESIGN: Wait list control 
   design. . SETTING: Outpatient clinics and oncology center. . SAMPLE: 20 women 
   with aromatase inhibitor-induced arthralgia. . METHODS: After baseline data were 
   collected, participants waited one month before they received acupressure once 
   per week for four weeks at a convenient time. The baseline data served as the 
   control comparison. Self-reported measures and blood samples were obtained at 
   baseline, at preintervention, weekly during the intervention, and at 
   post-intervention. . MAIN RESEARCH VARIABLES: The primary outcomes included pain 
   intensity, pain interference, stiffness, and physical function. Inflammatory 
   cytokines and chemokines were tested. . FINDINGS: After the four-week 
   intervention, participants reported decreases in worst pain and pain 
   interference, and improvements in physical function, cancer-related symptom 
   severity, and interference. The proinflammatory cytokines and chemokines 
   displayed a trend of a mean percentage reduction. The anti-inflammatory cytokine 
   interleukin-13 increased from pre- to postintervention. . CONCLUSIONS: Auricular 
   point acupressure is feasible and may be effective in managing arthralgia in 
   breast cancer survivors. . IMPLICATIONS FOR NURSING: Nurses can administer 
   acupressure in clinical settings, which could enhance the management of aromatase 
   inhibitor-induced arthralgia and contribute to a shift from traditional 
   disease-based biomedical models to a broader, integrative, medical paradigm for 
   managing aromatase inhibitor-induced arthralgia.
C1 School of Nursing, University of Pittsburgh, Pennsylvania.
   University of Pittsburgh.
   Hong Kong Polytechnic University.
   University of Pittsburgh.
   MGH Institute of Health Professions.
   University of Pittsburgh.
   University of Pittsburgh Cancer Institute and Hillman Cancer Center.
NR 0
TC 0
SN 1538-068
EI 
J9 Oncol Nurs Forum
PD JUN 21
PY 2017
VL 44
IS 4
BP 476
EP 487
DI 10.1188/17.ONF.476-487 
PG 11
WC Acupressure; Adult; Aged; Aged, 80 and over; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Cancer Survivors; Female; Humans; Middle Aged; Pain Management; methods; Pilot Projects; Quality of Life; Treatment Outcome
UT PubMed:28632237
PM 28632237
DA 2017-06-21
ER

PT J
AU Ge, AX
   Ryan, ME
   Giaccone, G
   Hughes, MS
   Pavletic, SZ
AF Ge, Adeline X Y
   Ryan, Mary E
   Giaccone, Giuseppe
   Hughes, Marybeth S
   Pavletic, Steven Z
TI Acupuncture treatment for persistent hiccups in patients with cancer.
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
AB OBJECTIVE: The objective of this study was to investigate the effects of 
   acupuncture treatment for persistent hiccups in cancer patients. DESIGN: The 
   study design was a retrospective case series. SETTINGS/LOCATION: The study 
   setting was the Clinical Research Center of the National Institutes of Health. 
   SUBJECTS: The subjects were 16 adult male patients ages 27-71 with cancer, with 
   persistent hiccups. INTERVENTIONS: There were one to three acupuncture sessions 
   over a 1-7-day period. OUTCOME MEASURES: Treatment efficacy was measured using a 
   hiccup assessment instrument pre- and post-treatment. The effects of acupuncture 
   on common symptoms reported by all patients were also evaluated. RESULTS: 
   Thirteen (13) patients experienced complete remission of persistent hiccups (p < 
   0.0001); 3 patients experienced decreased hiccups severity. Significant 
   improvement was observed in discomfort (p < 0.0001), distress (p < 0.0001), and 
   fatigue (p = 0.0078). CONCLUSIONS: This case series demonstrates that acupuncture 
   may be a clinically useful, safe, and low-cost therapy for persistent hiccups in 
   patients with cancer.
C1 Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA.age@mail.nih.gov
NR 0
TC 0
SN 1557-770
EI 1075-553
J9 J Altern Complement Med
PD JUN 26
PY 2010
VL 16
IS 7
BP 811
EP 6
DI 10.1089/acm.2009.0456 
PG -805
WC Acupuncture Therapy; Adult; Aged; Fatigue; etiology; Hiccup; classification; Humans; Male; Middle Aged; Neoplasms; complications; Pain; etiology; Pain Management; Remission Induction; Retrospective Studies; Severity of Illness Index; Stress, Psychological; etiology; Treatment Outcome
UT PubMed:20575702
PM 20575702
DA 2010-06-26
ER

PT J
AU Lukkahatai, N
   Zhang, J
   Benjasirisan, C
   Phongphanngam, S
   Shen, A
   Jaiman, P
   Kawi, J
   Smith, TJ
   Saligan, LN
AF Lukkahatai, Nada
   Zhang, Jingyu
   Benjasirisan, Chitchanok
   Phongphanngam, Sutthida
   Shen, Aomei
   Jaiman, Phakjira
   Kawi, Jennifer
   Smith, Thomas J
   Saligan, Leorey N
TI Acupuncture and Acupressure for Cancer Symptom Management: an Opinion Statement 
SO Current treatment options in oncology
LA English
DT Review
DE Acupressure; Acupuncture; Cancer; Symptom management
AB Symptom management remains a critical priority in oncology, particularly as many 
   survivors continue to experience fatigue, pain, sleep disturbance, neuropathy, 
   and psychological distress despite advances in treatment. Conventional 
   pharmacologic options often provide only partial relief and may be limited by 
   side effects. Acupuncture and acupressure have emerged as promising 
   non-pharmacologic approaches, but the supporting evidence is drawn from a broad 
   and heterogeneous literature. In this opinion paper, we provide a preliminary 
   overview of the current review-level evidence to highlight general trends and 
   evolving areas of promise, while emphasizing the need for further sham-controlled 
   studies to clarify effectiveness and guide integration of acupuncture and 
   acupressure into supportive oncology.
C1 School of Nursing, Johns Hopkins University, 525 N. Wolfe Street, Baltimore, MD, USA. nada.lukkahatai@jhu.edu.
   School of Nursing, Johns Hopkins University, 525 N. Wolfe Street, Baltimore, MD, USA.
   School of Nursing, Johns Hopkins University, 525 N. Wolfe Street, Baltimore, MD, USA.
   Department of Medical Nursing, Faculty of Nursing, Mahidol University, 
   School of Nursing, University of Phayao, Phayao, Thailand.
   Department of Nursing, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Centerfor Cancer, Tianjin, 300060, China.
   School of Nursing, Johns Hopkins University, 525 N. Wolfe Street, Baltimore, MD, USA.
   Cizik School of Nursing, The University of Texas Health Science Center at Houston, Houston, TX, USA.
   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
   School of Nursing, Rutgers University, Newark, NJ, USA.
NR 0
TC 0
SN 1534-627
EI 
J9 Curr Treat Options Oncol
PD JAN 13
PY 2026
VL 27
IS 1
BP 5
EP 5
DI 10.1007/s11864-025-01369-7 
PG 0
WC Humans; Acupressure; methods; Neoplasms; therapy; Acupuncture Therapy; methods; Disease Management; Treatment Outcome
UT PubMed:41528616
PM 41528616
DA 2026-01-13
ER

PT J
AU Chen, YB
   Leng, J
   Lin, BJ
   Xu, MH
AF Chen, Ya-Bei
   Leng, Jing
   Lin, Bo-Jie
   Xu, Ming-Hui
TI [Thunder-fire moxibustion combined with mifepristone for ovarian chocolate cyst 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE dysmenorrhea; mifepristone; ovarian chocolate cyst; randomized controlled trial (RCT); thunder-fire moxibustion
AB OBJECTIVE: To observe the clinical efficacy of thunder-fire moxibustion combined 
   with mifepristone for ovarian chocolate cyst dysmenorrhea with kidney deficiency 
   and blood stasis. METHODS: Seventy patients were randomly divided into an 
   observation group and a control group, 35 cases in each group. The patients in 
   the the control group were treated with oral administration of mifepristone, 10 
   mg each time, once a day; based on the treatment of the control group, the 
   patients in the observation group were treated with thunder-fire moxibustion at 
   Guanyuan (CV 4), Zigong (EX-CA 1), Xuehai (SP 10), once every other day. Both the 
   groups were treated for 3 months. The Cox menstrual symptom scale (CMSS) score, 
   the maximum cross-sectional area of ectopic cyst, and the serum levels of 
   transforming growth factor-β1 (TGF-β1) and interleukin-17 (IL-17) were observed 
   before and after treatment in the two groups. The clinical efficacy was 
   evaluated. RESULTS: Compared before treatment, the severity scores and duration 
   scores of CMSS as well as the serum levels of TGF-β1 were reduced after treatment 
   in the two groups (P<0.05), and the serum level of IL-17 in the observation group 
   was reduced (P<0.05); the reducing of the severity score and duration score of 
   CMSS as well as the serum levels of TGF-β1 and IL-17 in the observation group 
   were more significant than those in the control group (P<0.05). After treatment, 
   the maximum cross-sectional area of ectopic cyst in the two groups was decreased 
   (P<0.05), and the reducing in the observation group was more significant than 
   that in the control group (P<0.05). The total effective rate was 94.3% (33/35) in 
   the observation group, which was higher than 71.4% (25/35) in the control group 
   (P<0.05). CONCLUSION: Thunder-fire moxibustion combined with mifepristone could 
   significantly improve dysmenorrhea symptoms, shorten dysmenorrhea time and 
   promote atrophy of ovarian heterotopic cyst in patients with ovarian chocolate 
   cyst dysmenorrhea of kidney deficiency and blood stasis, and the mechanism may be 
   related to the reduction of serum levels of TGF-β1 and IL-17.
C1 College of Acupuncture-Moxibustion and Tuina, Guangxi University of CM, Nanning 530001, China
   Nanning Huidong Outpatient Department, Nanning 530200, GuangxiZhuang Autonomous Region.
   College of Acupuncture-Moxibustion and Tuina, Guangxi University of CM, Nanning 530001, China.
   Department of Plastic and Cosmetic Surgery, First Affiliated Hospital of Guangxi Medical University.
   College of Acupuncture-Moxibustion and Tuina, Guangxi University of CM, Nanning 530001, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD APR 1
PY 2021
VL 41
IS 2
BP 161
EP 4
DI 10.13703/j.0255-2930.20191011-0002 
PG -157
WC Acupuncture Points; Chocolate; Cysts; Dysmenorrhea; drug therapy; Female; Humans; Kidney; Mifepristone; Moxibustion
UT PubMed:33788463
PM 33788463
DA 2021-04-01
ER

PT J
AU Genovese, TJ
   Mao, JJ
AF Genovese, Timothy J
   Mao, Jun J
TI Genetic Predictors of Response to Acupuncture for Aromatase Inhibitor-Associated 
SO Pain medicine (Malden, Mass.)
LA English
DT Journal Article
AB OBJECTIVE: To evaluate the associations between polymorphisms in two genes, 
   catechol-O-methyltransferase and T-cell leukemia/lymphoma 1 A, and 
   acupuncture-mediated pain reduction among breast cancer survivors with aromatase 
   inhibitor-associated arthralgia. DESIGN, SETTING, AND SUBJECTS: Biospecimens were 
   obtained from 38 patients enrolled in a clinical trial of acupuncture for 
   aromatase inhibitor-associated arthralgia in postmenopausal hormone 
   receptor-positive breast cancer survivors. METHODS: We used polymerase chain 
   reaction to genotype the rs4680 (Val158Met) and rs4633 (His62His) variants in the 
   catechol-O-methyltransferase gene and rs2369049 (A > G) and rs7158782 (A > G) 
   variants in the T-cell leukemia/lymphoma 1 A gene. Response to acupuncture was 
   defined by 30% reduction in end-of-treatment average pain, measured by the Brief 
   Pain Inventory. We used Fisher exact tests to evaluate associations between 
   genotype and treatment response. RESULTS: Among participants, all six (15.8%) 
   subjects who expressed AA in locus rs4680 responded to acupuncture. In a combined 
   analysis, the 18 (47.4%) subjects with the responder genotype at either rs4680 
   (AA) or rs2369049 (GG or AG) were significantly more likely to respond to 
   acupuncture than those without (77.8% vs 45.0%, P = 0.039). CONCLUSIONS: Specific 
   genetic variations at loci rs4680 and rs2369049 are associated with response to 
   acupuncture-type intervention for management of arthralgia. These results serve 
   as a proof of concept for applying a precision medicine framework to the study of 
   cancer pain management.
C1 The Warren Alpert Medical School, Brown University, Providence, Rhode Island.
   Department of Integrative Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
NR 0
TC 0
SN 1526-463
EI 1526-237
J9 Pain Med
PD JUN 19
PY 2018
VL 20
IS 1
BP 191
EP 194
DI 10.1093/pm/pny067 
PG 3
WC Acupuncture Therapy; methods; Aged; Aromatase Inhibitors; adverse effects; Arthralgia; complications; Breast Neoplasms; complications; Cancer Survivors; statistics & numerical data; Catechol O-Methyltransferase; genetics; Female; Humans; Middle Aged; Pain Measurement; Treatment Outcome
UT PubMed:29912452
PM 29912452
DA 2018-06-19
ER

PT J
AU Deng, G
   Giralt, S
   Chung, DJ
   Landau, H
   Siman, J
   Li, QS
   Lapen, K
   Mao, JJ
AF Deng, Gary
   Giralt, Sergio
   Chung, David J
   Landau, Heather
   Siman, Jonathan
   Li, Qing S
   Lapen, Kaitlyn
   Mao, Jun J
TI Reduction of Opioid Use by Acupuncture in Patients Undergoing Hematopoietic Stem 
SO Pain medicine (Malden, Mass.)
LA English
DT Journal Article
DE Acupuncture; Cancer Pain; Opioids; Pain Management
AB OBJECTIVE: To evaluate acupuncture as a nonpharmacologic intervention for pain 
   management in patients undergoing hematopoietic stem cell transplantation (HSCT). 
   METHODS: Adult patients with multiple myeloma undergoing high-dose melphalan 
   chemotherapy and autologous peripheral blood HSCT were randomized to receive 
   either true (TA) or sham acupuncture (SA) once daily for five days starting on 
   the day after chemotherapy. Use of pain medications and pain scores were assessed 
   at baseline and at days 5, 15, and 30 after transplantation. RESULTS: Among 60 
   evaluable subjects, the SA group (vs TA) had greater than five times odds of 
   increasing pain medication use from baseline. Among patients who were opioid 
   nonusers at baseline, all 15 patients in the TA group remained free from opioid 
   use at the end of the study. In contrast, 20% of those in the SA group (four of 
   the 20 patients) started to use opioids after chemotherapy and stem cell infusion 
   (day 5) and 40% (eight of the 20) had become opioid users by day 30 after HSCT 
   (Fisher exact test P = 0.006). Among patients who were taking opioids at 
   baseline, 14% in the TA group vs 10% in the SA group increased opioid intake at 
   day 5, and 21% (TA) vs 30% (SA) at day 30 (P = 0.86). CONCLUSIONS: Acupuncture 
   appears to significantly reduce the need for pain medications during HSCT and the 
   number of post-HSCT opioid users among baseline opioid nonusers. It warrants 
   further studies as an opioid-sparing intervention for pain in HSCT patients.
C1 Integrative Medicine Service.
   Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York.
   Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York.
   Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York.
   Seattle Cancer Care Alliance, Seattle, Washington.
   Integrative Medicine Service.
   Medical School, University of Illinois at Chicago, Chicago, Illinois.
   Integrative Medicine Service.
NR 0
TC 0
SN 1526-463
EI 1526-237
J9 Pain Med
PD SEP 10
PY 2019
VL 21
IS 3
BP 636
EP 642
DI 10.1093/pm/pnz190 
PG 6
WC Acupuncture Therapy; methods; Adult; Analgesics, Opioid; therapeutic use; Cancer Pain; therapy; Female; Hematopoietic Stem Cell Transplantation; adverse effects; Humans; Male; Middle Aged; Multiple Myeloma; therapy; Pain Management; methods; Pilot Projects
UT PubMed:31498394
PM 31498394
DA 2019-09-10
ER

PT J
AU Mazzei, LG
   Bergamaschi, CC
   Silva, MT
   Lopes, LC
AF Mazzei, Lauren Giustti
   Bergamaschi, Cristiane de Cássia
   Silva, Marcus Tolentino
   Lopes, Luciane Cruz
TI Use of IMMPACT domains in clinical trials of acupuncture for chronic pain: a 
SO BMJ open
LA English
DT Review
DE acupuncture; chronic pain; methodological survey
AB INTRODUCTION: Pain is one of the most common and most debilitating complaints 
   among patients. It affects the individual, their relationship with friends and 
   family, their ability to function at work, and their sociability. Acupuncture is 
   one of the therapeutic resources for managing chronic pain. Given the variability 
   of outcome measures in controlled randomised clinical trials on 
   non-oncologicchronic pain (CRCT-NOCP), the Initiative in Methods, Measurements 
   and Pain Assessment in Clinical Trials (IMMPACT) recommends six domains to be 
   covered in evaluating the effectiveness of treatments for chronic pain. 
   OBJECTIVE: To check whether the methodological quality of outcome reporting in 
   published trials has used IMMPACT recommendations in measuring CRCT-NOCP outcomes 
   when acupuncture was used as a treatment. METHOD: This is a methodological study. 
   We will systematically search for eligible studies in specific databases with a 
   defined strategy. We will use the MeSHterms of 'acupuncture', 'chronic pain' and 
   similar terms, without restrictions on idiom. Eligible studies will include those 
   which are randomised and chose NOCP patients to be treated with acupuncture or 
   control (sham acupuncture or no acupuncture), recruited after September 2004, 
   with ≥100 patients. The measured outcomes are to be the presence of outcome 
   domains recommended by IMMPACT, domains reported by the patient or clinician, 
   tools used to measure such domains, as well as other features of the studies. We 
   shall conduct a regression analysis to explore factors which can be associated 
   with the presence of outcome domains according to IMMPACT recommendations. ETHICS 
   AND DISSEMINATION: This survey will be submitted for presentation at congresses 
   and for publication in a scientific journal. The findings obtained in this study 
   will allow us to measure the quality of the evidence and provide greater 
   transparency in decisions regarding the use of acupuncture as a viable 
   alternative to managing chronic pain.
C1 Department of Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, São Paulo, Brazil.
   Department of Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, São Paulo, Brazil.
   Department of Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, São Paulo, Brazil.
   Department of Pharmaceutical Sciences Graduate Program, University of Sorocaba, Sorocaba, São Paulo, Brazil.
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD OCT 1
PY 2017
VL 7
IS 9
BP e014904
EP e014904
DI 10.1136/bmjopen-2016-014904 
PG 1
WC Acupuncture Therapy; Chronic Pain; therapy; Humans; Pain Management; methods; Pain Measurement; Randomized Controlled Trials as Topic; Research Design; Treatment Outcome
UT PubMed:28963280
PM 28963280
DA 2017-10-01
ER

PT J
AU Xia, B
   Xie, Y
   Hu, S
   Xu, T
   Tong, P
AF Xia, Bingjiang
   Xie, Yiping
   Hu, Songfeng
   Xu, Taotao
   Tong, Peijian
TI Effect of Auricular Point Acupressure on Axial Neck Pain After Anterior Cervical 
SO Pain medicine (Malden, Mass.)
LA English
DT Journal Article
DE Anterior Cervical Discectomy and Fusion; Auricular Point Acupressure; Axial Neck Pain
AB OBJECTIVES: To evaluate the effect of auricular point acupressure (APA) on axial 
   neck pain after anterior cervical discectomy and fusion (ACDF) surgery. DESIGN: A 
   prospective randomized controlled trial was performed. SUBJECTS AND SETTING: 
   Twenty-nine participants were randomly divided into two groups, real or sham APA. 
   Participants were enrolled from Shaoxing Hospital of Traditional Chinese 
   Medicine, affiliated with Zhejiang Chinese Medical University. METHODS: Eligible 
   participants received a four-week real or sham APA treatment according to their 
   assigned groups. The clinical outcomes were assessed by the criteria of Hosono et 
   al., the Brief Pain Inventory Short Form (BPI), and the 36-item Short Form Health 
   Survey (SF-36). In addition, plasma interleukin (IL)-1β, IL-6, and tumor necrosis 
   factor (TNF)-α were analyzed. RESULTS: Patients with severe or moderate axial 
   neck pain accounted for 28.6% and 35.7% in the real APA group at the end of 
   treatment and one-month follow-up. BPI scores were decreased in the real APA 
   group at the end of treatment and one-month follow-up. The total mean score of 
   SF-36 was improved in the real APA group and significantly higher than in the 
   sham APA group. Additional, the levels of IL-1β, IL-6, and TNF-α were decreased 
   in the real APA group. CONCLUSIONS: The findings supported the therapeutic effect 
   of APA treatment on axial neck pain after ACDF surgery, and they exert the 
   possible therapeutic effect on downregulating the levels of plasma IL-1β, IL-6, 
   and TNF-α.
C1 Shaoxing Hospital of Traditional Chinese Medicine (TCM), affiliated with Zhejiang Chinese Medical University, Shaoxing, Zhejiang, China.
   Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
   Research Department of Spine and Joint in Shaoxing, Shaoxing, Zhejiang, China.
   Shangyu Hospital of TCM, Shaoxing, Zhejiang, China.
   Shaoxing Hospital of Traditional Chinese Medicine (TCM), affiliated with Zhejiang Chinese Medical University, Shaoxing, Zhejiang, China.
   Research Department of Spine and Joint in Shaoxing, Shaoxing, Zhejiang, China.
   Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
   Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
NR 0
TC 0
SN 1526-463
EI 
J9 Pain Med
PD MAY 16
PY 2017
VL 19
IS 1
BP 193
EP 201
DI 10.1093/pm/pnx112 
PG 8
WC Acupressure; methods; Adult; Aged; Cervical Vertebrae; Diskectomy; adverse effects; Female; Humans; Male; Middle Aged; Neck Pain; therapy; Pain, Postoperative; therapy; Patient Satisfaction; Spinal Fusion; adverse effects; Treatment Outcome
UT PubMed:28505292
PM 28505292
DA 2017-05-16
ER

PT J
AU Shen, LY
   Fu, XF
   Zeng, Q
   Mao, XW
   Hong, QY
   Liu, XJ
   Li, HQ
   Hu, H
AF Shen, Ling-Yu
   Fu, Xiao-Fei
   Zeng, Qin
   Mao, Xue-Wen
   Hong, Qiu-Yang
   Liu, Xiao-Jing
   Li, Huan-Qin
   Hu, Hui
TI Comparison of the efficacy of different frequency electroacupuncture in the 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Electroacupuncture; Frequency; Polycystic ovary syndrome; Randomized controlled trial
AB OBJECTIVES: To compare the effects of 2 Hz continuous wave and 2 Hz/100 Hz 
   dilatational wave setting in electroacupuncture(EA) on ovulation frequency, 
   hormone levels, body fat parameters, quality of life and depression-anxiety level 
   in polycystic ovary syndrome (PCOS) patients with abdominal obesity. METHODS: 
   PCOS patients with abdominal obesity were randomly divided into low-frequency 
   group (n=29) and dilatational wave group (n=29). Patients in both groups were 
   treated with "Tongtiaodaimai" (regulating Dai Meridian) acupuncture therapy, and 
   EA was applied to bilateral Daimai (GB26), Tianshu (ST25), Shenshu (BL23) and 
   Ciliao (BL32). The low-frequency group received EA using a continuous wave at a 
   frequency of 2 Hz, while the dilatational wave group received dilatational wave 
   at a frequency of 2 Hz/100 Hz. Both groups received treatment for 30 min each 
   time, 3 times per week for 12 consecutive weeks. Ovulation frequency was 
   calculated according to the ovulation cycle. The contents of serum anti-Mullerian 
   hormone (AMH) and sex hormone binding globulin (SHBG) were detected with 
   electrochemiluminescence method. Body weight (BW) and waist circumference (WC) 
   were measured, and body mass index (BMI) and waist-height ratio (WHtR) were 
   calculated. PCOS questionnaire (Chi-PCOSQ), self-rating anxiety scale (SAS) and 
   self-rating depression scale (SDS) were evaluated. RESULTS: Compared with before 
   treatment, both the low-frequency group and the dilatational wave group showed an 
   increase in ovulation frequency (P<0.01, P<0.05), and a decrease in BW, BMI, WC, 
   WHtR, and SDS score (P<0.01, P<0.05)；the dilatational wave group showed decreased 
   serum AMH contents (P<0.05) and increased serum SHBG contents (P<0.05), the 
   scores related to acne, fatigue, and dysmenorrhea in the Chi-PCOSQ increased 
   (P<0.01, P<0.05). Compared with the low-frequency group, the dilatational wave 
   group showed a reduction (P<0.05) in WC after treatment. CONCLUSIONS: 2 Hz/100 Hz 
   dilatational wave EA is equally effective as 2 Hz low-frequency EA in improving 
   ovulation frequency. In terms of reducing WC in abdominal obesity type PCOS 
   patients, 2 Hz/100 Hz dilatational wave EA is superior to 2 Hz low-frequency EA. 
   2 Hz/100 Hz dilatational wave EA can decrease serum AMH, increase serum SHBG, and 
   improve symptoms of acne, fatigue, and dysmenorrhea.
C1 Department of Acupuncture and Moxibustion, Beijing Shunyi Hospital of Traditional Chinese Medicine, Beijing 101300, China. 1017152977@qq.com.
   Department of Acupuncture and Moxibustion, Guangdong Provincial Hospital of TCM, Guangzhou 510120.
   Department of Acupuncture and Moxibustion, Beijing Shunyi Hospital of Traditional Chinese Medicine, Beijing 101300, China.
   Department of Acupuncture and Moxibustion, Beijing Shunyi Hospital of Traditional Chinese Medicine, Beijing 101300, China.
   Department of Acupuncture and Moxibustion, Beijing Shunyi Hospital of Traditional Chinese Medicine, Beijing 101300, China.
   Department of Acupuncture and Moxibustion, Beijing Shunyi Hospital of Traditional Chinese Medicine, Beijing 101300, China.
   Acupuncture Center, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing 100010. carland95@126.com.
   Department of Acupuncture and Moxibustion, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078. dfzhenjiu@126.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD DEC 26
PY 2023
VL 48
IS 12
BP 1266
EP 1273
DI 10.13702/j.1000-0607.20230575 
PG 7
WC Female; Humans; Electroacupuncture; Obesity, Abdominal; therapy; Quality of Life; Polycystic Ovary Syndrome; therapy; Dysmenorrhea; Acupuncture Points; Obesity; therapy; Acne Vulgaris
UT PubMed:38146250
PM 38146250
DA 2023-12-26
ER

PT J
AU Wang, C
   Zhu, JC
   Zheng, ZW
   Xiong, YZ
   Ma, XF
   Gong, YC
   He, YL
AF Wang, Chao
   Zhu, Jun-Chen
   Zheng, Zhi-Wen
   Xiong, Ying-Zong
   Ma, Xing-Fu
   Gong, Yue-Cheng
   He, Ye-Lin
TI [Effects of acupotomy on partial movement gait and serum tumor necrosis factor-α, 
SO Zhongguo gu shang = China journal of orthopaedics and traumatology
LA chi
DT Journal Article
DE Acupotomy therapy; Gait analysis; Interleukin-1β; Osteoarthritis, knee; Tumor necrosis factor-α
AB OBJECTIVE: To explore effects of acupotomy on pain, function, gait and serum 
   inflammatory factors in patients with knee osteoarthritis(KOA). METHODS: From 
   December 2017 to June 2019, 110 patients with KOA were collected and divided into 
   acupotomy group(56 cases) and western medicine group(54 cases) by using random 
   number table method. In acupotomy group, there were 16 males and 40 females, aged 
   from 46 to 74 years old with an average of (62.98±6.68) years old, the course of 
   disease ranged from 1 to 240 months with an average of 24.5(15.25, 33.00) 
   months;were treated with acupotomy on the pain points around knee joint once a 
   week for 3 weeks. In western medicine group, there were 18 males and 36 females, 
   aged from 47 to 73 years old with an average of (64.19±5.98 ) years old;the 
   course of disease ranged from 1 to 220 months with an average of 25.00(13.75, 
   33.00) months;were took celecoxib capsule orally, 200 mg once a day for 3 weeks. 
   Oxford Knee Score(OKS) was performed before treatment, 3 weeks and 3 months after 
   treatment. Gait kinematics analysis and serum levels of tumor necrosis 
   factor-α(TNF-α) and interleukin-1β (IL-1β) were measured before and after 
   treatment for 3 weeks. RESULTS: All patients were followed up from 6 to 24 months 
   with an average of(15.03±4.55) months. OKS between two groups decreased 
   significantly at 3 weeks and 3 months after treatment(P<0.001). Functional scores 
   and overall scores in acupotomology group were significantly decreased at 3 
   months compared with 3 weeks after treatment(P<0.001). OKS of acupotomy group 
   were significantly lower than those of western medicine group at 3 weeks and 3 
   months after treatment(P<0.05). Gait speed, frequency and length between two 
   groups were significantly improved at 3 weeks after treatment(P<0.05). At 3 weeks 
   after treatment, gait freguency of acupotomy group was significantly improved 
   compared with western medicine group(P<0.05). TNF-α and IL-1β were significantly 
   lower in both groups at 3 weeks after treatment than before treatment(P<0.05). At 
   3 weeks after treatment, level of IL-1 β was lower in western medicine group than 
   in acupotomy group(P<0.05), and difference in TNF-α level was not statistically 
   significant(P>0.05). CONCLUSION: Acupotomology of pain points could significantly 
   improve pain, function, gait, and decreased serum inflammatory factors at early 
   to mid stage of KOA patients, in particular, it is superior to non-steroidal 
   anti-inflammatory drugs in terms of knee function recovery and cadence 
   improvement.
C1 The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, Anhui, China.
   The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, Anhui, China.
   The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, Anhui, China.
   The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, Anhui, China.
   The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, Anhui, China.
   The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, Anhui, China.
   The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, Anhui, China.
NR 0
TC 0
SN 
EI 1003-003
J9 Zhongguo Gu Shang
PD SEP 21
PY 2022
VL 35
IS 9
BP 848
EP 52
DI 10.12200/j.issn.1003-0034.2022.09.009 
PG -796
WC Acupuncture Therapy; Aged; Anti-Inflammatory Agents, Non-Steroidal; therapeutic use; Celecoxib; therapeutic use; Female; Gait; Humans; Interleukin-1beta; Male; Middle Aged; Osteoarthritis, Knee; drug therapy; Pain; drug therapy; Tumor Necrosis Factor-alpha
UT PubMed:36124455
PM 36124455
DA 2022-09-21
ER

PT J
AU Yu, N
   Yang, F
   Zhao, X
   Guo, Y
   Xu, Y
   Pang, G
   Gong, Y
   Wang, S
   Liu, Y
   Fang, Y
   Yu, K
   Yao, L
   Wang, H
   Zhang, K
   Liu, B
   Wang, Z
   Guo, Y
   Xu, Z
AF Yu, Nannan
   Yang, Fuming
   Zhao, Xue
   Guo, Yongming
   Xu, Yuan
   Pang, Guangchang
   Gong, Yinan
   Wang, Shenjun
   Liu, Yangyang
   Fang, Yuxin
   Yu, Kun
   Yao, Lin
   Wang, Hui
   Zhang, Kuo
   Liu, Baohu
   Wang, Zhenguo
   Guo, Yi
   Xu, Zhifang
TI Manual acupuncture at ST36 attenuates rheumatoid arthritis by inhibiting M1 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE adjuvant-induced arthritis; macrophage polarization; manual acupuncture; regulatory T cells; transforming growth factor β1
AB OBJECTIVES: Acupuncture has been found to be effective at relieving many 
   inflammatory pain conditions, including rheumatoid arthritis (RA). We aimed to 
   assess the anti-inflammatory potential of manual acupuncture (MA) treatment of RA 
   using adjuvant-induced arthritic (AIA) rats and to explore the underlying 
   mechanisms. METHODS: The anti-inflammatory and analgesic actions of MA at ST36 
   (Zusanli) in AIA rats were assessed using paw withdrawal latency and swelling, 
   histological examination and cytokine detection by enzyme-linked immunoassay 
   (ELISA). The cell-cell communication (CCC) network was analyzed with a multiplex 
   immunoassay of 24 immune factors expressed in the inflamed joints, and the 
   macrophage and Treg populations and associated cytokines regulated by MA were 
   investigated using reverse-transcription quantitative polymerase chain reaction 
   (RT-qPCR), ELISA and flow cytometry. RESULTS: MA markedly decreased heat 
   hyperalgesia and paw swelling in AIA rats. MA-treated rats also exhibited 
   decreased levels of pro-inflammatory cytokines (tumor necrosis factor (TNF)-α, 
   interleukin (IL)-1β) coupled with increased anti-inflammatory cytokines (IL-10, 
   transforming growth factor (TGF)-β1) in the ankle joints at protein and mRNA 
   levels. CCC network analysis confirmed that macrophages are of critical 
   importance and are potential therapeutic targets in RA. Repeated treatment with 
   MA triggered a macrophage phenotypic switch in the paws, with fewer M1 
   macrophages. Prominent increases in the Treg cell population and TGF-β1 in the 
   popliteal lymph nodes demonstrated the immunomodulatory effects of MA. 
   Furthermore, a selective TGF-β1-receptor inhibitor, SB431542, attenuated the 
   anti-inflammatory effects of MA and MA-induced suppression of the levels of 
   M1-released cytokines. CONCLUSION: These findings provide novel evidence that the 
   anti-inflammatory and analgesic effects of MA on RA act through phenotypic 
   modulation involving the inhibition of M1 macrophage polarization and an increase 
   in the Treg cell population, highlighting the potential therapeutic advantages of 
   acupuncture in controlling pain and ameliorating inflammatory conditions.
C1 Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Department of Traditional Chinese Medicine, the First Affiliated Hospital, the 
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Department of Rehabilitation, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, P.R. China.
   Xi'an Encephalopathy Hospital of Traditional Chinese Medicine, Xi'an, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD MAY 20
PY 2022
VL 41
IS 2
BP 96
EP 109
DI 10.1177/09645284221085278 
PG 13
WC Rats; Animals; T-Lymphocytes, Regulatory; metabolism; Transforming Growth Factor beta1; Cytokines; Arthritis, Rheumatoid; drug therapy; Acupuncture Therapy; Tumor Necrosis Factor-alpha; Macrophages; metabolism; Pain; drug therapy; Anti-Inflammatory Agents; adverse effects; Arthritis, Experimental; drug therapy
UT PubMed:35585798
PM 35585798
DA 2022-05-20
ER

PT J
AU Zeng, JC
   Zhang, RL
   Wei, XJ
   Lin, GH
AF Zeng, Jing-Chun
   Zhang, Rui-Lin
   Wei, Xiao-Jing
   Lin, Guo-Hua
TI Acupuncture for improving a case of widespread herpes zoster after non-Hodgkin's 
SO Explore (New York, N.Y.)
LA English
DT Journal Article
DE Acupuncture; Alternative therapy; Chemotherapy; Herpes zoster; Non-Hodgkin's lymphoma; Varicella Zoster Virus
AB BACKGROUND: Herpes zoster presents as clustered blisters on one side of the body, 
   accompanied by nerve pain. This is caused by reactivation of the varicella zoster 
   virus, and it occurs primarily in people with weakened immunity. Tumor and 
   chemotherapy drugs can impair the patient's immune function, induce herpes zoster 
   and prolong the course of disease.In these patients, skin changes can last for 
   months and blisters can recur and cause serious complications such as 
   postherpetic neuralgia.Acupuncture is a common alternative therapy for herpes 
   zoster in East Asia. CASE PRESENTATION: We report a case of an elderly male 
   patient with widespread herpes zoster in the trunk after non-Hodgkin's lymphoma 
   chemotherapy. The patient had received conventional treatment with valaciclovir 
   and mecobalamin within 24 hours of symptom onset. Because neither the clustered 
   blisters nor the nerve pain were improved a week later, acupuncture and related 
   techniques were applied. These included electro-acupuncture, surrounding 
   acupuncture, fire acupuncture, and cupping. The patient recovered 20 days after 
   the herpes zoster attack, and there were no adverse reactions during the 
   treatment process. CONCLUSIONS: This case suggests that acupuncture and related 
   techniques are effective interventions for this condition.This case report is 
   innovative because it shows that acupuncture as an adjuvant treatment can improve 
   the skin lesions in patients with HZ after tumour chemotherapy, relieve pain, and 
   shorten the course of HZ.
C1 First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. 
   First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
   Guangzhou University of Chinese Medicine, Guangzhou, China.
   First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. 
EM tcmlin-801@163.com
NR 0
TC 0
SN 1878-754
EI 
J9 Explore (NY)
PD AUG 22
PY 2021
VL 18
IS 5
BP 608
EP 611
DI 10.1016/j.explore.2021.08.003 
PG 3
WC Acupuncture Therapy; Aged; Blister; Herpes Zoster; Herpesvirus 3, Human; Humans; Lymphoma, Non-Hodgkin; Male; Neoplasm Recurrence, Local; Neuralgia
UT PubMed:34417113
PM 34417113
DA 2021-08-22
ER

PT J
AU Chen, HY
   Li, SG
   Cho, WC
   Zhang, ZJ
AF Chen, Hai-Yong
   Li, Shi-Guang
   Cho, William Cs
   Zhang, Zhang-Jin
TI The role of acupoint stimulation as an adjunct therapy for lung cancer: a 
SO BMC complementary and alternative medicine
LA English
DT Journal Article
AB BACKGROUND: Lung cancer is the leading cause of death in cancer patients. 
   Clinical studies showed that a variety of acupoint stimulations have been 
   extensively used for lung cancer patients, including needle insertion, injection 
   with herbal extraction, plaster application, and moxibustion. However, the role 
   of acupoint stimulation in lung cancer treatment was not fully reviewed. METHODS: 
   In the present study, we conducted a systematic review and meta-analysis on the 
   role of acupoint stimulation in lung cancer treatment by electronic and manual 
   searching in seven databases, including Ovid (Ovid MEDLINE, AMED, CAB Abstracts, 
   EMBASE), EBSCOhost research databases (Academic Search premier, MEDLINE, CIHAHL 
   Plus), PreQuest (British Nursing Index, ProQuest Medical Library, ProQuest 
   Dissertations & Theses A&I, PsycINFO), and ISI web of knowledge (Web of Science, 
   BIOSIS Citation Index, Biological Abstracts, Chinese Science Citation Database), 
   CNKI, Wanfang Data, and CQVIP. RESULTS: Our study showed that acupoint 
   stimulation has strong immunomodulatory effect for lung cancer patients as 
   demonstrated by the significant increase of IL-2, T cell subtypes (CD3+ and CD4+, 
   but not CD8+ cells), and natural killer cells. Further analysis revealed that 
   acupoint stimulation remarkably alleviates the conventional therapy-induced bone 
   marrow suppression (hemoglobin, platelet, and WBC reduction) in lung cancer 
   patients, as well as decreases nausea and vomiting. The pooled studies also 
   showed that acupoint stimulation can improve Karnofsky performance status, 
   immediate tumor response, quality of life (EORCT-QLQ-C30), and pain control of 
   cancer patients. CONCLUSIONS: Acupoint stimulation is found to be effective in 
   lung cancer treatment, further confirmatory evaluation via large scale randomized 
   trials is warranted.
C1 School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, G/F, 10 Sassoon Road, Pokfulam, Hong Kong Special AdministrativeRegion, China. williamcscho@gmail.com.
NR 0
TC 0
SN 1472-688
EI 
J9 BMC Complement Altern Med
PD DEC 19
PY 2013
VL 13
IS 
BP 362
EP 362
DI 10.1186/1472-6882-13-362 
PG 0
WC Acupuncture Points; Acupuncture Therapy; Antineoplastic Agents; adverse effects; CD3 Complex; blood; CD4 Antigens; blood; Combined Modality Therapy; Humans; Lung Neoplasms; blood; Lymphocyte Count; Nausea; complications; Vomiting; chemically induced
UT PubMed:24344728
PM 24344728
DA 2013-12-19
ER

PT J
AU Zeng, K
   Dong, HJ
   Chen, HY
   Chen, Z
   Li, B
   Zhou, QH
AF Zeng, Ke
   Dong, Hui-Juan
   Chen, Hong-Yun
   Chen, Zhe
   Li, Bai
   Zhou, Qing-Hui
TI Wrist-ankle acupuncture for pain after transcatheter arterial chemoembolization 
SO The American journal of Chinese medicine
LA English
DT Journal Article
AB This study was designed to evaluate the analgesic effect of wrist-ankle 
   acupuncture (WAA) for patients with primary liver cancer (PLC) after 
   transcatheter arterial chemoembolization (TACE). Sixty PLC patients with 
   post-TACE visual analog pain intensity scores greater than 3 were divided equally 
   into two groups receiving either WAA or oral morphine sulphate (MOR) for 
   post-TACE pain. Pain intensity scores were reassessed at 1, 2, 4, and 6 h after 
   analgesic intervention. Patients were also monitored for adverse reactions to 
   analgesic treatment. Pain scores recorded when the patients first felt pain after 
   TACE showed no statistical difference between the two groups (p > 0.05). WAA and 
   MOR had indistinguishable degrees of pain relief 1, 2, and 4 h after analgesic 
   intervention (p > 0.05). At 6 h after intervention, the WAA group experienced 
   significantly greater pain relief than the MOR group (p < 0.05). Incidence of 
   abdominal distension was lower in the WAA group than in the MOR group (p < 0.05). 
   The results suggest that WAA not only had an analgesic effect equal to or greater 
   than MOR in PLC patients with moderate to severe post-TACE pain, but also reduced 
   the incidence of post-operative abdominal distention.
C1 School of Traditional Chinese Medicine, Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China.
NR 0
TC 0
SN 1793-685
EI 
J9 Am J Chin Med
PD APR 9
PY 2014
VL 42
IS 2
BP 289
EP 302
DI 10.1142/S0192415X14500190 
PG 13
WC Acupuncture Analgesia; methods; Adult; Aged; Analgesics, Opioid; Ankle; Catheterization, Peripheral; adverse effects; Chemoembolization, Therapeutic; adverse effects; Female; Hepatic Artery; Humans; Liver Neoplasms; therapy; Male; Middle Aged; Morphine; administration & dosage; Pain, Postoperative; etiology; Treatment Outcome; Wrist
UT PubMed:24707863
PM 24707863
DA 2014-04-09
ER

PT J
AU Efverman, A
AF Efverman, Anna
TI Understanding Placebo and Nocebo Responses Based on a Randomized Sham-Controlled 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; and integrative medicine; cancer; complementary; contextual effects; expectations; nursing; oncology; psycho-oncology; traditional
AB Objective: Since placebo and nocebo-responses during acupuncture therapy are 
   rarely studied in clinical contexts, the objective was to investigate placebo and 
   nocebo-responses in a clinical context through comparing positive and negative 
   side-effects between genuine and sham acupuncture, and to identify factors 
   modifying placebo and nocebo-responses. Methods: Patients reported positive 
   side-effects (non-intended positive effects) or negative side-effects 
   (non-intended negative effects) of genuine (penetrating; n = 109) or sham 
   (telescopic non-penetrating; n = 106) acupuncture during 5 weeks of 
   chemoradiation for cancer. Results: The genuine and the sham acupuncture group 
   reported rather similar frequencies of positive (P-values .223-.800) or negative 
   (P-values .072-1.0) side-effects: relaxation 59%/57% of the patients, improved 
   mood 46%/38%, improved sleep 38%/38%, pain-reduction 36%/28%, tiredness 42%/42%, 
   feeling cold 37%/31%, sweating 23%/21%, and dizziness 20%/12%. Positive 
   side-effects occurred in 79% of patients who highly believed acupuncture to be 
   effective, compared to in 0% of patients who did not believe. Other factors 
   associated with placebo-response were female sex (P = .042), anxious mood 
   (P = .007), depressed mood (P = .018), and blinding-success (P = .033). Factors 
   associated with nocebo response were female sex (P = .049), younger age 
   (P = .010), and needle-induced pain (P = .014). Sham-treated patients 
   experiencing positive side-effects experienced better quality of life at the end 
   of the treatment period (mean, m 64 on a scale 0-100 millimetres, Standard 
   Deviation, SD, ±26.1 mm) than those who did not (m 48 ± 25.5 mm), P = .048 
   (adjusted for other characteristics). Conclusions: Clinically significant levels 
   of placebo and nocebo effects commonly occurred during acupuncture therapy in 
   integrative cancer care and this paper identified factors modifying these 
   responses. This implicates that acupuncture-delivering therapists striving to 
   maximize placebo-responses and minimize nocebo-responses may considering 
   strengthen the patient's treatment expectations, and offer a pleasant, pain-free, 
   acupuncture treatment.
C1 University of Gävle, Gävle, Sweden.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD NOV 16
PY 2024
VL 23
IS 
BP 15347354241300068
EP 15347354241300068
DI 10.1177/15347354241300068 
PG 1
WC Adult; Aged; Female; Humans; Male; Middle Aged; Acupuncture Therapy; methods; Neoplasms; therapy; Nocebo Effect; Placebo Effect
UT PubMed:39548800
PM 39548800
DA 2024-11-16
ER

PT J
AU Shi, K
   Tang, Y
   He, F
   Xiao, X
   Zhang, J
   Jin, Y
   Wang, Y
   Zhang, Q
AF Shi, Kejin
   Tang, Ying
   He, Fengyi
   Xiao, Xiao
   Zhang, Jiayuan
   Jin, Yuxia
   Wang, Yunxia
   Zhang, Qi
TI The maintenance effect of acupuncture on the side effects of breast cancer 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Breast cancer is common among women throughout the world and 
   endocrine therapy is an established part of its treatment. But, unfortunately, 
   this has also resulted in intolerable side effects affecting the quality of life. 
   Acupuncture has been widely used to treat endocrine-related side effects in 
   patients with breast cancer, but how long its effect can be maintained has not 
   been published. The systematic review is designed to evaluate the maintenance 
   efficacy of acupuncture for related side effects after breast cancer endocrine 
   therapy. METHODS AND ANALYSIS: We will search for the following databases: 
   PubMed, Embase, Cochrane Library, Web of Science, including China National 
   Knowledge Infrastructure (CNKI), WanFang Data, Technology Periodical Database 
   (VIP), and China Biology Medicine (CBM) from inception to May 2020. Two reviewers 
   will search these databases, collect all articles, and assess the quality of 
   studies separately, and there will be no limitations on language. The primary 
   outcomes will be assessed using acupuncture for endocrine-related hot flashes and 
   joint pain duration (1 month, 3 months, 6 months). Measurement tools include the 
   Kupperman index, Brief Pain Inventory Short Form (BPI-SF), the Western Ontario 
   and McMaster Universities Osteoarthritis Index (WOMAC), the Brief Pain 
   Inventory-Short (BPI-SF). We will use RevMan V.5.3 for meta-analysis and employ 
   the Grading of Recommendations Assessment, Development and Evaluation System to 
   assess the quality of evidence. RESULTS: This systematic review will evaluate the 
   maintenance efficacy of acupuncture on the side effects of breast cancer 
   endocrine therapy. CONCLUSION: This study will provide high-quality current 
   evidence of how long its effect can be maintained after acupuncture for related 
   side effects after breast cancer endocrine therapy. ETHICS AND DISSEMINATION: 
   Ethical committee approval is not required for this systematic review as patient 
   data will not be collected. This study will help to inform doctors and 
   researchers on the duration of acupuncture treatment for endocrine-related hot 
   flashes and joint pain. The results will be published in a peer-reviewed journal 
   and will be disseminated in relevant conferences. INPLASY REGISTRATION NUMBER: 
   INPLASY202040024.
C1 Chengdu university of traditional Chinese medicine, Chengdu, Sichuan province, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JUN 17
PY 2020
VL 99
IS 24
BP e20567
EP e20567
DI 10.1097/MD.0000000000020567 
PG 1
WC Acupuncture Therapy; Antineoplastic Agents, Hormonal; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Hot Flashes; chemically induced; Humans; Meta-Analysis as Topic; Systematic Reviews as Topic
UT PubMed:32541483
PM 32541483
DA 2020-06-17
ER

PT J
AU Shang, R
   Pan, T
   Wang, F
   Jin, H
   Nan, X
   Song, C
AF Shang, Rui
   Pan, Ting
   Wang, Fengyang
   Jin, Hui
   Nan, Xi
   Song, Chenyu
TI Current and future trends of acupuncture as an adjuvant therapy in cancer: A 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Acupuncture, as one of the representatives of complementary 
   therapies, is often used as an adjunctive therapy in the treatment of cancer and 
   related complications with beneficial results. METHODS: We selected the Web of 
   Science Core Collection (WOSCC) database as the data source and searched to 
   obtain relevant literatures on the application of acupuncture in cancer 
   treatment. The relevant literature was analyzed using CiteSpace (version 6.1.R6) 
   and VOSviewer (version 1.6.20). RESULTS: A total of 592 publications were 
   included, with an overall upward trend in the number of publications. There were 
   135 countries or institutions involved, with China as the most published country. 
   There were 1888 related institutions, and Memorial Sloan Kettering Cancer Center 
   was the institution with the most publications. A total of 3067 authors were 
   involved, and there were obvious collaborations between authors. There were 190 
   related journals, and J Clin Oncol was the most cited journal. The most 
   frequently occurring keywords were breast cancer and management, but also other 
   related topics such as quality of life, chemotherapy, and complementary. 
   CONCLUSION: Acupuncture is gaining increasing attention as an adjunctive therapy 
   in cancer treatment programs. Currently, relevant research focuses on acupuncture 
   to alleviate cancer-induced comorbid symptoms, such as pain and insomnia. Future 
   research is gradually shifting toward spiritual care, Colorectal Cancer Surgery, 
   and systematic review.
C1 JiLin Cancer Hospital, Changchun, Jilin Province, China.
   The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin Province, China.
   Changchun University, Changchun, Jilin Province, China.
   JiLin Cancer Hospital, Changchun, Jilin Province, China.
   JiLin Cancer Hospital, Changchun, Jilin Province, China.
   JiLin Cancer Hospital, Changchun, Jilin Province, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JUL 19
PY 2024
VL 103
IS 29
BP e38663
EP e38663
DI 10.1097/MD.0000000000038663 
PG 1
WC Humans; Bibliometrics; Acupuncture Therapy; methods; Neoplasms; therapy; Combined Modality Therapy
UT PubMed:39029068
PM 39029068
DA 2024-07-19
ER

PT J
AU Asadpour, R
   Kessel, KA
   Bruckner, T
   Sertel, S
   Combs, SE
AF Asadpour, Rebecca
   Kessel, Kerstin A
   Bruckner, Tom
   Sertel, Serkan
   Combs, Stephanie E
TI Randomized study exploring the combination of radiotherapy with two types of 
SO Trials
LA English
DT Journal Article
DE Acupuncture; Fatigue; Quality of life (QOL); Radiotherapy; Sham-controlled trial
AB BACKGROUND: Adverse effects such as fatigue, pain, erythema, nausea and vomiting 
   are commonly known in patients undergoing irradiation (RT) alone or in 
   combination with chemotherapy (RCHT). Patients suffering from these symptoms are 
   limited in their daily life and their quality of life (QOL) is often reduced. As 
   addressed in several trials, acupuncture can cause amelioration of these specific 
   disorders. Especially for pain symptoms, several groups have shown efficacy of 
   acupuncture. To what extent the difference between traditional acupuncture (verum 
   acupuncture) and false acupuncture (sham acupuncture) is in reducing side effects 
   and improvement of QOL is not clear. METHODS/DESIGN: ROSETTA is a prospective 
   randomized phase II trial (version 1.0) to examine the efficacy of traditional 
   acupuncture in patients with RT-related side effects. In the experimental (verum) 
   arm (n = 37) an experienced acupuncture-trained person will treat dedicated 
   acupuncture points. In the control (sham) arm (n = 37) sham acupuncture will be 
   performed to provide a blinded comparison of results. DISCUSSION: This is the 
   first randomized prospective trial to evaluate the effect of traditional 
   acupuncture on RT-related side effects such as fatigue and QOL. TRIAL 
   REGISTRATION: ClinicalTrials.gov, NCT02674646 . Registered on 8 December 2015.
C1 Department of Radiation Oncology, Technische Universität München (TUM), Klinikum rechts der Isar, Ismaninger Straße 22, 81675, Munich, Germany.
   Department of Radiation Oncology, Technische Universität München (TUM), Klinikum rechts der Isar, Ismaninger Straße 22, 81675, Munich, Germany.
   Department of Radiation Sciences (DRS), Institute of Innovative Radiotherapy 
   Department of Medical Biometry, Institute of Medical Biometry and Informatics (IMBI), Universität Heidelberg, Im Neuenheimer Feld 305, 69120, Heidelberg,Germany.
   Praxisgemeinschaft Prof. Sertel & Dr. Passerino , Rottstrasse 39, 67061, Ludwigshafen am Rhein, Germany.
   Department of Otorhinolaryngology, Head & Neck Surgery, University of Heidelberg, 
   Department of 325 Otorhinolaryngology, Head and Neck Surgery, University Hospital CHUV, 326 Bâtiment hospitalier, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
   Department of Radiation Oncology, Technische Universität München (TUM), Klinikum rechts der Isar, Ismaninger Straße 22, 81675, Munich, Germany.stephanie.combs@tum.de.
   Department of Radiation Sciences (DRS), Institute of Innovative Radiotherapy 
   Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, Munich, Germany. stephanie.combs@tum.de.
NR 0
TC 0
SN 1745-621
EI 
J9 Trials
PD AUG 31
PY 2017
VL 18
IS 1
BP 398
EP 398
DI 10.1186/s13063-017-2139-5 
PG 0
WC Acupuncture Points; Acupuncture Therapy; adverse effects; Fatigue; etiology; Germany; Humans; Neoplasms; diagnosis; Prospective Studies; Quality of Life; Radiotherapy; adverse effects; Surveys and Questionnaires; Time Factors; Treatment Outcome
UT PubMed:28851420
PM 28851420
DA 2017-08-31
ER

PT J
AU Zhang, Z
   Wang, C
   Gu, G
   Li, H
   Zhao, H
   Wang, K
   Han, F
   Wang, G
AF Zhang, Zhaodi
   Wang, Changsong
   Gu, Guangying
   Li, Huiping
   Zhao, Haifang
   Wang, Kun
   Han, Fei
   Wang, Guonian
TI The effects of electroacupuncture at the ST36 (Zusanli) acupoint on cancer pain 
SO Anesthesia and analgesia
LA English
DT Journal Article
AB BACKGROUND: Several studies have addressed the expression of transient receptor 
   potential vanilloid subfamily 1(TRPV1) playing an important role in the 
   generation of cancer pain. Electroacupuncture (EA) is an effective method of 
   acupuncture shown to attenuate different kinds of pain such as inflammatory, 
   neuropathic, and cancer. In this study, we investigated the effect of EA on 
   cancer pain caused by intraplantar injection of Walker 256 carcinoma cells and 
   cancer-driven TRPV1 expression in the dorsal root ganglions (DRGs). METHODS: Rats 
   were randomly divided into 4 groups: the nontumor cell inoculation group (normal 
   control, n = 8); Walker 256 carcinoma cell inoculation group (tumor control, n = 
   8); sham point electrical stimulation treatment with Walker 256 carcinoma cell 
   inoculation group (SES, n = 8); EA treatment with Walker 256 carcinoma cell 
   inoculation group (EA, n = 8). The time courses of thermal, mechanical 
   sensitivity, and spontaneous nocifensive behavior were determined. In addition, 
   TRPV1 expression in DRGs was observed by quantitative real-time polymerase chain 
   reaction and Western blotting. RESULTS: Injection of cancer cells decreased the 
   paw withdrawal threshold, increased spontaneous nocifensive behavior, and induced 
   significant thermal hyperalgesia that was attenuated by EA at the ST36 acupoint 
   (2 Hz, 0.3 ms, ≤1 mA). TRPV1 mRNA and protein in DRGs were upregulated in the 
   cancer pain model, and EA at ST36 acupoint counteracted the cancer-driven 
   upregulation of TRPV1 expression in the corresponding DRGs. CONCLUSIONS: EA at 
   ST36 could attenuate cancer-induced pain, at least in part, through suppressing 
   TRPV1 mRNA and protein upregulation in the DRGs.
C1 Department of Anesthesiology, Third Affiliated Hospital of Harbin Medical University, No. 6 Baojian Rd., Nangang District, Harbin 150081, China.
NR 0
TC 0
SN 1526-759
EI 
J9 Anesth Analg
PD JAN 19
PY 2012
VL 114
IS 4
BP 879
EP 85
DI 10.1213/ANE.0b013e318246536d 
PG -794
WC Acupuncture Analgesia; Acupuncture Points; Animals; Carcinoma 256, Walker; physiopathology; Electroacupuncture; Male; Pain, Intractable; therapy; RNA, Messenger; analysis; Rats; Rats, Wistar; TRPV Cation Channels; analysis
UT PubMed:22253272
PM 22253272
DA 2012-01-19
ER

PT J
AU Song, HJ
   Seo, HJ
   Lee, H
   Son, H
   Choi, SM
   Lee, S
AF Song, Hyun Jin
   Seo, Hyun-Ju
   Lee, Heeyoung
   Son, Heejeong
   Choi, Sun Mi
   Lee, Sanghun
TI Effect of self-acupressure for symptom management: a systematic review.
SO Complementary therapies in medicine
LA English
DT Journal Article
DE Acupressure; Self-administration; Signs and Symptoms
AB OBJECTIVES: To assess the efficacy and safety of self-administered acupressure to 
   alleviate symptoms of various health problems, including allergic disease, 
   cancer, respiratory disease, dysmenorrhea, perceived stress, insomnia, and sleep 
   disturbances. METHODS: We searched core, Korean, Chinese, and Japanese databases, 
   including Ovid-MEDLINE, Ovid-EMBASE, the Cochrane Central Register of Controlled 
   Trials (CENTRAL), the Cumulative Index to Nursing and Allied Health Literature 
   (CINAHL), six representative electronic Korean medical databases, China National 
   Knowledge Infrastructure (CNKI), and Japan Science and Technology Information 
   Aggregator (J-STAGE). We included randomized controlled trials (RCTs) and 
   quasi-RCTs that examined disease-specific effects or symptom relief, adverse 
   reactions, and quality-of-life (QOL) for self-administered acupressure. Data 
   collection and assessment of the methodological quality of the included studies 
   were conducted by two independent reviewers. RESULTS: Eight RCTs and two 
   quasi-RCTs showed positive effects and safety of self-acupressure therapy in 
   clinically diverse populations. Quality assessment revealed moderate quality for 
   the RCTs, with 50% or more of the trials assessed as presenting a low risk of 
   bias in seven domains. All of the selected 10 studies reported positive effects 
   for primary outcomes of self-acupressure therapy for symptom management, 
   including significant improvements in symptom scores in allergic disease, nausea 
   and vomiting in cancer, symptom scores in respiratory disease, pain symptoms in 
   dysmenorrhea, and stress/fatigue scores and sleep disturbances in healthy people. 
   CONCLUSIONS: Our findings suggest that self-administered acupressure shows 
   promise to alleviate the symptoms of various health problems. Therefore, further 
   research with larger samples and methodologically well-designed RCTs is required 
   to establish the efficacy of self-administered acupressure.
C1 School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.
   Department of Nursing, College of Medicine, Chosun University, 309 Pilmum-daero, Dong-gu, Gwangju 501-759, South Korea. 
   Public Health Medical Service, Seoul National University Bundang Hospital, Seongnam, South Korea.
   Graduate School of Public Health, Seoul National University, Seoul, South Korea.
   Korea Institute of Oriental Medicine, Daejeon, South Korea.
   Korea Institute of Oriental Medicine, Daejeon, South Korea.
EM shj5th@korea.ac.kr
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD FEB 1
PY 2015
VL 23
IS 1
BP 68
EP 78
DI 10.1016/j.ctim.2014.11.002 
PG 10
WC Acupressure; methods; Disease Management; Humans; Quality of Life; Self Care; methods
UT PubMed:25637155
PM 25637155
DA 2015-02-01
ER

PT J
AU Chen, J
   Zhang, Y
   Li, X
   Wan, Y
   Ji, X
   Wang, W
   Kang, X
   Yan, W
   Fan, Z
AF Chen, Jiheng
   Zhang, Yunxiao
   Li, Xiaoxi
   Wan, You
   Ji, Xinqiang
   Wang, Wei
   Kang, Xiaozheng
   Yan, Wanpu
   Fan, Zhiyi
TI Efficacy of transcutaneous electrical acupoint stimulation combined with general 
SO Thoracic cancer
LA English
DT Journal Article
DE Analgesia; general anesthesia; sedation; transcutaneous acupoint electrical stimulation; video-assisted thoracoscopic surgery
AB BACKGROUND: Multimodal opioid-sparing analgesia is a key component of an enhanced 
   recovery pathway after surgery that aims to improve postoperative recovery. 
   Transcutaneous electrical acupoint stimulation (TEAS) is assumed to alleviate 
   pain and anxiety and to modify the autonomic nervous system. This study aimed to 
   determine the efficacy of TEAS for sedation and postoperative analgesia in lung 
   cancer patients undergoing thoracoscopic pulmonary resection. METHODS: A total of 
   80 patients were randomized into two groups: the TEAS group and the sham TEAS 
   combined with general anesthesia group. Postoperative pain levels at six, 24, 
   48 hours, and one month after surgery were measured using the visual analogue 
   scale (VAS). Bispectral index (BIS) score during the TEAS prior to anesthetic 
   induction, Observer's Assessment of Alertness/Sedation (OAAS) score, sufentanil 
   consumption during postoperative patient-controlled intravenous analgesia (PCIA), 
   number of total and effective attempts of PCIA pump use, and incidence of 
   postoperative nausea and vomiting were recorded and analyzed statistically. 
   RESULTS: Patients in the TEAS group had significantly lower VAS scores at six, 
   24, and 48 hours after surgery (P < 0.01); lower BIS scores at 10, 20, and 
   30 minutes before induction (P < 0.01); lower levels of postoperative sufentanil 
   consumption; lower number of PCIA attempts and effective rates (P < 0.01); lower 
   incidences of nausea at 0, six, 24, and 48 hours; and lower incidence of vomiting 
   at 24 hours after surgery (P < 0.05). The postoperative OAAS scores were similar 
   between the groups. CONCLUSIONS: TEAS could be a feasible approach for sedation 
   and postoperative analgesia in thoracoscopic pulmonary resection.
C1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University CancerHospital and Institute, Beijing, China.
   Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University CancerHospital and Institute, Beijing, China.
   Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University CancerHospital and Institute, Beijing, China.
   Neuroscience Research Institute and Department of Neurobiology, Peking University and Key Laboratory of Neuroscience of the Ministry of Education and the NationalHealth Commission, Beijing, China.
   Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Medical Record Statistics, Peking UniversityCancer Hospital & Institute, Beijing, China.
   Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Medical Record Statistics, Peking UniversityCancer Hospital & Institute, Beijing, China.
   Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), The First Department of Thoracic Surgery, Peking UniversityCancer Hospital and Institute, Beijing, China.
   Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), The First Department of Thoracic Surgery, Peking UniversityCancer Hospital and Institute, Beijing, China.
   Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University CancerHospital and Institute, Beijing, China.
NR 0
TC 0
SN 1759-771
EI 1759-770
J9 Thorac Cancer
PD FEB 18
PY 2020
VL 11
IS 4
BP 928
EP 934
DI 10.1111/1759-7714.13343 
PG 6
WC Acupuncture Points; Adolescent; Adult; Aged; Anesthesia, General; methods; China; epidemiology; Double-Blind Method; Enhanced Recovery After Surgery; Female; Follow-Up Studies; Humans; Lung Neoplasms; pathology; Male; Middle Aged; Minimally Invasive Surgical Procedures; methods; Nausea; epidemiology; Pain, Postoperative; epidemiology; Prognosis; Vomiting; epidemiology; Young Adult
UT PubMed:32062864
PM 32062864
DA 2020-02-18
ER

PT J
AU Ben-Arye, E
   Gressel, O
   Keshet, Y
   Zaritsky, V
   Kassem, S
   Segev, Y
   Samuels, N
AF Ben-Arye, Eran
   Gressel, Orit
   Keshet, Yael
   Zaritsky, Vika
   Kassem, Sameer
   Segev, Yakir
   Samuels, Noah
TI War and Cancer: Exploring Patient Narratives in a Randomized Integrative Oncology 
SO Psycho-oncology
LA English
DT Journal Article
DE cancer; integrative medicine; integrative oncology; pain; supportive and palliative care; war
AB STUDY OBJECTIVE: The current war in Israel has affected quality of life 
   (QoL)-related concerns among patients with cancer. Integrative oncology (IO) 
   provides complementary medicine within supportive and palliative care. The study 
   examined an IO program in northern Israel for cancer and war-related concerns. 
   METHODS: This qualitative study, nested within a prospective randomized 
   controlled trial, examined patients undergoing oncology and palliative care 
   expressing cancer and war-related QoL concerns referred by oncology healthcare 
   providers to an IO program. Patients were randomized to manual-relaxation with 
   (Group A) or without (Group B) acupuncture. Narratives were recorded in MYCaW 
   (Measure Yourself Concerns and Well-being) questionnaires immediately and after 
   24 h. Narrative excerpts were qualitatively analyzed using ATLAS.Ti software for 
   systematic coding. RESULTS: Patient narratives (Group A, 67; Group B, 58) focused 
   primarily on themes which included a sense of calmness and reduced emotional 
   distress (e.g., stress, anxiety, worries, nervousness), more prominently in Group 
   B (manual-relaxation only; 55/56 immediately/after 24 h); and reduced pain 
   severity, more so in Group A (with acupuncture; 19/24). Most excerpts described 
   improved QoL in both groups (142/147, 97%) immediately after IO treatments, less 
   so at 24 h (103/135). CONCLUSIONS: Narratives of patients facing cancer- and 
   war-related QoL challenges due to the ongoing war in Israel describe a beneficial 
   impact of IO treatments, both immediately and after 24 h. Manual-relaxation 
   without acupuncture was more likely to improve emotional concerns, with pain 
   relief more apparent with the addition of acupuncture. Further qualitative and 
   quantitative research is needed to explore these findings.
C1 Integrative Oncology Program, The Oncology Service
   Lin, Carmel, and Zebulun Medical Centers, Clalit Health Services, Haifa, Israel.
   Ruth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of 
   Integrative Oncology Program, The Oncology Service
   Lin, Carmel, and Zebulun Medical Centers, Clalit Health Services, Haifa, Israel.
   Ruth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of 
   Department of Sociology, Western Galilee Academic College, Acre, Israel.
   Ruth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Ruth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Department of Internal Medicine, Lady Davis Carmel Medical Center, Haifa, Israel.
   Unit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
   Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.
NR 0
TC 0
SN 1099-161
EI 1057-924
J9 Psychooncology
PD MAY 6
PY 2025
VL 34
IS 5
BP e70172
EP e70172
DI 10.1002/pon.70172 
PG 1
WC Humans; Male; Neoplasms; psychology; Female; Quality of Life; psychology; Middle Aged; Israel; Acupuncture Therapy; Qualitative Research; Aged; Integrative Oncology; methods; Narration; Palliative Care; psychology; Prospective Studies; Adult; Relaxation Therapy; methods
UT PubMed:40326225
PM 40326225
DA 2025-05-06
ER

PT J
AU Thicke, LA
   Hazelton, JK
   Bauer, BA
   Chan, CW
   Huntoon, EA
   Novotny, PJ
   Sloan, JA
   Wahner-Roedler, DL
AF Thicke, Lori A
   Hazelton, Jennifer K
   Bauer, Brent A
   Chan, Carl W
   Huntoon, Elizabeth A
   Novotny, Paul J
   Sloan, Jeff A
   Wahner-Roedler, Dietlind L
TI Acupuncture for treatment of noncyclic breast pain: a pilot study.
SO The American journal of Chinese medicine
LA English
DT Journal Article
AB Noncyclic breast pain is a common breast disorder prompting women to seek medical 
   evaluation. We aimed to perform a pilot study on the relief of noncyclic breast 
   pain using acupuncture. Thirty-seven women seen at a diagnostic breast clinic 
   between April 2003 and January 2009 were enrolled. Treatment consisted of four 
   acupuncture sessions over two weeks, with three months of follow-up. Response to 
   treatment was measured with use of a breast pain questionnaire, a quality of life 
   (QOL) questionnaire, and the Cleeland Brief Pain Inventory (BPI) assessed at 
   baseline, end of treatment, and three months after treatment. Data were analyzed 
   using standard descriptive statistics. Twenty-two patients completed four 
   acupuncture sessions. Pain described as throbbing and heavy decreased 
   significantly after acupuncture (p = 0.04 and p = 0.03, respectively). After 
   treatment, pain scores (on the 10-point BPI scale) decreased by an average of 3.5 
   points for the worst pain during the previous month (p = 0.001), by 2.7 points 
   for average pain (p < 0.001), and by 2.3 points for pain interference (p = 
   0.002). The percentage of patients reporting a clinically meaningful decrease of 
   2 points from baseline to the end of treatment included 67% (12/18) for the worst 
   pain, 65% (11/17) for average pain, and 56% (10/18) for pain interference. QOL 
   data showed no improvement in QOL measures (mental, physical, emotional, social, 
   or spiritual well-being). The results of this preliminary study suggest that a 
   randomized controlled trial may be warranted to evaluate the effect of 
   acupuncture on noncyclic breast pain, as well as the optimal frequency of 
   acupuncture treatments.
C1 Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
NR 0
TC 0
SN 1793-685
EI 
J9 Am J Chin Med
PD NOV 16
PY 2011
VL 39
IS 6
BP 1117
EP 29
DI 10.1142/S0192415X11009445 
PG -1088
WC Acupuncture Points; Acupuncture Therapy; Adult; Breast Neoplasms; complications; Female; Follow-Up Studies; Humans; Mastodynia; etiology; Pilot Projects; Quality of Life; Treatment Outcome; Young Adult
UT PubMed:22083985
PM 22083985
DA 2011-11-16
ER

PT J
AU Shi, H
   Huang, Q
   Yao, WP
   He, L
   Zhang, CD
   Yang, ZM
AF Shi, Hao
   Huang, Qian
   Yao, Wen-Ping
   He, Lei
   Zhang, Chuan-Dong
   Yang, Zheng-Ming
TI [Randomized controlled trial on cervical spondylotic radiculopathy of 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acupuncture; Cervical spondylotic radiculopathy; Thunder-fire moxibustion; Wind-cold-damp type
AB OBJECTIVE: To explore the therapeutic effect of acupuncture combined with 
   thunder-fire moxibustion on cervical spondylotic radiculopathy of wind-cold-damp 
   type and its impacts on the conduction velocity of F wave of median nerve and 
   ulnar nerve, as well as hypersensitive C-responsive protein (hs-CRP), interleukin 
   6 (IL-6), IL-1β and tumor necrosis factor α (TNF-α) in serum. METHODS: A total of 
   94 patients with cervical spondylotic radiculopathy of wind-cold-damp type were 
   randomly divided into a control group and a combined therapy group, 47 cases in 
   each group. In the control group, acupuncture was applied to Fengchi (GV20), 
   Tianzhu (BL10), Neck-Jiaji (EX-B5), Dazhui (GV14) and others, 30 min each time, 
   once daily, 5 times a week, totally for 4 weeks. In the combined therapy group, 
   on the base of the treatment as the control group, the thunder-fire moxibustion 
   was adopted over GV20, EX-B5, GV14, Jianjing (ST21) and Tianzong (SI11), 20 min 
   each time, once every other day, for 4 weeks in total. After the treatment, the 
   curative effect was compared in the patients between two groups. The short-form 
   McGill pain questionnaire (SF-MPQ), the neck specificity scale and the MOS 
   36-item short form health survey (SF-36) were scored. The conduction velocity of 
   F wave in median nerve and ulnar nerve was detected by electromyography. The 
   expression of hs-CRP was measured by immunoturbidimetry. IL-6, IL-1β and TNF-α in 
   serum were determined by enzyme linked immunosorbent assay. RESULTS: The total 
   effective rate in the combined therapy group was 95.7% (45/47), which was higher 
   than 80.9% (38/47) in the control group (P<0.05). Compared with their own 
   pretreatment, the scores of SF-MPQ, neck specificity scale and SF-36 were all 
   obviously improved after treatment in the patients of either group (P<0.05), 
   while the conduction velocity of F wave in median nerve and ulnar nerve was 
   accelerated and hs-CRP, IL-6, IL-1β and TNF-α in serum were decreased (P<0.05). 
   Compared with the control group, the improvements in the scores of SF-MPQ, neck 
   specificity scale and SF-36 were more obvious (P<0.05), the increase of the 
   conduction velocity of F wave in median nerve and ulnar nerve and the decrease of 
   hs-CRP, IL-6, IL-1β and TNF-α in serum were more remarkable (P<0.05) in the 
   combined therapy group. CONCLUSION: Acupuncture combined with thunder-fire 
   moxibustion relieves the clinical symptoms of cervical spondylotic radiculopathy 
   of wind-cold-damp type.
C1 Department of Acupuncture and Moxibustion, Lianyungang Hospital of Traditional Chinese Medicine Affi-liated to Kangda College of Nanjing Medical University,Lianyungang 222000, Jiangsu Province, China
   Clinical Medicine Department ofKangda College of Nanjing Medical University, Lianyungang 222000, JiangsuProvince.
   Department of Acupuncture and Moxibustion, Lianyungang Hospital of Traditional Chinese Medicine Affi-liated to Kangda College of Nanjing Medical University,Lianyungang 222000, Jiangsu Province, China.
   Department of Acupuncture and Moxibustion, Lianyungang Hospital of Traditional Chinese Medicine Affi-liated to Kangda College of Nanjing Medical University,Lianyungang 222000, Jiangsu Province, China.
   Department of Acupuncture and Moxibustion, Lianyungang Hospital of Traditional Chinese Medicine Affi-liated to Kangda College of Nanjing Medical University,Lianyungang 222000, Jiangsu Province, China.
   Department of Preventive Treatment, Lianyungang Hospital of Traditional Chinese Medicine Affi-liated to Kangda College of Nanjing Medical University, Lianyungang222000, Jiangsu Province, China.
   Department of Acupuncture and Moxibustion, Lianyungang Hospital of Traditional Chinese Medicine Affi-liated to Kangda College of Nanjing Medical University,Lianyungang 222000, Jiangsu Province, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JAN 1
PY 2022
VL 46
IS 12
BP 1036
EP 42
DI 10.13702/j.1000-0607.20210006 
PG -994
WC Acupuncture Points; Acupuncture Therapy; Humans; Moxibustion; Radiculopathy; therapy; Wind
UT PubMed:34970881
PM 34970881
DA 2022-01-01
ER

PT J
AU Yeh, CH
   Lukkahatai, N
   Campbell, C
   Sair, H
   Zhang, F
   Mensah, S
   Garry, C
   Zeng, J
   Chen, C
   Pinedo, M
   Khoshnoodi, M
   Smith, TJ
   Saligan, LN
AF Yeh, Chao Hsing
   Lukkahatai, Nada
   Campbell, Claudia
   Sair, Haris
   Zhang, Fengzhi
   Mensah, Sylvanus
   Garry, Courtney
   Zeng, Jing
   Chen, Changying
   Pinedo, Mariela
   Khoshnoodi, Mohammad
   Smith, Thomas J
   Saligan, Leorey N
TI Preliminary Effectiveness of Auricular Point Acupressure on Chemotherapy-Induced 
SO Pain management nursing : official journal of the American Society of Pain 
LA English
DT Journal Article
AB PURPOSE: To reduce chemotherapy-induced neuropathy (CIN)-a significant challenge 
   among cancer patients following chemotherapy-we explored the effects of auricular 
   point acupressure (APA), which involves needleless, acupuncture-like stimulation 
   on specific ear points. DESIGN/METHOD: This pilot study examined the effects of a 
   4-week APA intervention in the management of CIN. Descriptive analysis was used 
   to examine the changes in study outcomes. RESULTS: Fifteen participants were 
   enrolled. Two participants dropped out because they developed new medical 
   conditions. Thirteen participants completed the study (87% retention rate). Study 
   participants had more severe symptoms in their lower extremities (i.e., toes, 
   feet, soles) than in their upper extremities (i.e., fingers, wrists, elbows). 
   After the 4-week APA intervention, the mean percentage change scores ranged from 
   38% (tingling) to 49% (numbness); compared to pre-intervention, the therapeutic 
   effects of APA were sustained at the 1-month follow-up. Function in both upper 
   and lower extremities improved after the APA intervention (≥28%) and continued to 
   improve at the 1-month follow-up (≥36%). CONCLUSIONS: Preliminary results from 
   this small sample provide initial evidence of the effectiveness of APA on CIN. 
   Future studies should confirm these results using a larger sample, a comparative 
   sham control, and an examination of the underlying physiological mechanisms of 
   the anti-CIN effects of APA. CLINICAL IMPLICATIONS: APA may provide an 
   inexpensive and effective complementary approach for the self-management of CIN. 
   Once the seeds have been taped to the patient's ear by the provider, patients are 
   empowered to self-manage their CIN in their own environment.
C1 Johns Hopkins University School of Nursing, Baltimore, Maryland. 
   Johns Hopkins University School of Nursing, Baltimore, Maryland.
   Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
   Department of Radiology, Johns Hopkins University School of Medicine, 600 N. Wolfe St, Phipps 455, Baltimore, Maryland.
   Department of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
   Johns Hopkins University School of Nursing, Baltimore, Maryland.
   Johns Hopkins University School of Nursing, Baltimore, Maryland.
   Chengdu Medical College School of Nursing, Chengdu, Sichuan, China.
   The Nursing College of Zhengzhou University, No. 100 Science Ave, Zhengzhou, Henan, China.
   Johns Hopkins University School of Nursing, Baltimore, Maryland.
   Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
   Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.
   National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland.
EM cyeh13@jhu.edu
NR 0
TC 0
SN 1532-863
EI 
J9 Pain Manag Nurs
PD JUN 4
PY 2019
VL 20
IS 6
BP 614
EP 622
DI 10.1016/j.pmn.2019.04.005 
PG 8
WC Acupressure; methods; Adult; Antineoplastic Agents; adverse effects; Drug Therapy; methods; Ear; innervation; Female; Humans; Male; Middle Aged; Neuralgia; etiology; Outcome Assessment, Health Care; standards; Self Report; Surveys and Questionnaires; Treatment Outcome
UT PubMed:31155279
PM 31155279
DA 2019-06-04
ER

PT J
AU Liang, Y
   Bao, G
   Gong, L
   Zhou, J
   Kong, X
   Ran, R
   Shao, X
   Jiang, Y
   Zhang, W
   Liu, B
   Du, J
   Fang, J
   Nie, N
   Ji, C
   Fang, J
AF Liang, Yi
   Bao, Guanai
   Gong, Liyan
   Zhou, Jie
   Kong, Xiangming
   Ran, Ran
   Shao, Xiaomei
   Jiang, Yongliang
   Zhang, Weiping
   Liu, Boyi
   Du, Junying
   Fang, Junfan
   Nie, Na
   Ji, Conghua
   Fang, Jianqiao
TI Evaluating the analgesic effect and advantage of transcutaneous electrical 
SO Trials
LA English
DT Journal Article
DE Cancer-related pain; Randomized controlled trial; Study protocol; TEAS
AB BACKGROUND: Transcutaneous electrical acupoint stimulation (TEAS), which is also 
   known as acupuncture-like transcutaneous electrical nerve stimulation (TENS), has 
   been widely used in acute or chronic pain. However, previous research has not 
   demonstrated that TEAS is effective for cancer-related pain. Opioid drugs are 
   strongly recommended for treating cancer-related pain, but opioid-induced 
   immunosuppression is still the most intractable drug-induced medical problem. 
   Evaluating the efficacy and potential advantage of TEAS combined with opioid 
   drugs in moderate and severe cancer-related pain in China is important because 
   such studies are lacking. METHODS/DESIGN: This trial is a multicenter, 
   prospective randomized controlled clinical trial. In total, 160 patients who were 
   enrolled from two hospitals in the Zhejiang Province (China) will be randomly 
   allocated into two groups: a TEAS group and sham TEAS group without acupoint 
   electrical stimulation. Both groups will receive a 21-day interval of 
   chemotherapy and conventional cancer pain therapy. Fifteen treatment sessions 
   will be performed over a three-week period. The primary outcomes will be measured 
   by changes in the Numerical Rating Scale (NRS) scores and equivalent dosage of 
   morphine at baseline, three weeks of treatment and one two-week follow-up. The 
   secondary outcome measures include cellular immunity function, life quality 
   assessment, opioids side effects assessment, and safety and compliance 
   evaluation. DISCUSSION: This trial is expected to clarify whether TEAS is 
   effective for cancer-related pain. These results demonstrate the advantage of 
   TEAS combined with opioid drugs on improving immune function and decreasing 
   opioid induced side effects. TRIAL REGISTRATION: Chinese Clinical Trial Registry, 
   ChiCTR-13003803 . Registered on 27 August 2013.
C1 Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, 310005,Zhejiang Province, China.
   The Third Clinical Medical College of Zhejiang Chinese Medical University, No. 
   The Zhejiang Cancer Hospital, No. 1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang Province, China.
   The Zhejiang Cancer Hospital, No. 1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang Province, China.
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, 310005,Zhejiang Province, China.
   The Zhejiang Cancer Hospital, No. 1 Banshan East Road, Gongshu District, Hangzhou, 310022, Zhejiang Province, China.
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, 310005,Zhejiang Province, China.
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, 310005,Zhejiang Province, China.
   The Third Clinical Medical College of Zhejiang Chinese Medical University, No. 
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, 310005,Zhejiang Province, China.
   The Third Clinical Medical College of Zhejiang Chinese Medical University, No. 
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, 310005,Zhejiang Province, China.
   The Third Clinical Medical College of Zhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang Province, China.
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, 310005,Zhejiang Province, China.
   The Third Clinical Medical College of Zhejiang Chinese Medical University, No. 
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, 310005,Zhejiang Province, China.
   The Third Clinical Medical College of Zhejiang Chinese Medical University, No. 
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, 310005,Zhejiang Province, China.
   The Clinical Research Institute of Zhejiang Provincial Hospital of TCM, No.54 Youdian Road, Xihu District, Hangzhou, 310006, Zhejiang Province, China.
   Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, 310005,Zhejiang Province, China. fangjianqiao7532@163.com.
   The Third Clinical Medical College of Zhejiang Chinese Medical University, No. 
NR 0
TC 0
SN 1745-621
EI 
J9 Trials
PD JAN 13
PY 2019
VL 20
IS 1
BP 40
EP 40
DI 10.1186/s13063-018-3145-y 
PG 0
WC Acupuncture Points; Adolescent; Adult; Aged; Analgesics, Opioid; adverse effects; Cancer Pain; diagnosis; China; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Pain Measurement; Prospective Studies; Quality of Life; Randomized Controlled Trials as Topic; Time Factors; Transcutaneous Electric Nerve Stimulation; adverse effects; Treatment Outcome; Young Adult
UT PubMed:30635007
PM 30635007
DA 2019-01-13
ER

PT J
AU Zhong, XM
   Fang, JF
   Jiang, B
   Zhou, J
   Cai, YQ
   Liang, Y
   Fang, JQ
   Chen, F
   Du, JY
AF Zhong, Xue-Mei
   Fang, Jun-Fan
   Jiang, Bin
   Zhou, Jie
   Cai, Yang-Qian
   Liang, Yi
   Fang, Jian-Qiao
   Chen, Feng
   Du, Jun-Ying
TI [Early intervention of bone-nearby acupuncture combined with electroacupuncture 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE bone cancer pain; bone-nearby acupuncture; electroacupuncture; histone deacetylase 2 (HDAC2);μ-opioid recepter (MOR); histone deacetylase1 (HDAC1); histone dorsal root ganglia; morphine tolerance
AB OBJECTIVE: To observe the effect of early intervention of bone-nearby acupuncture 
   (BNA) combined with electroacupuncture (EA) on the expression of histone 
   deacetylase1(HDAC1), histone deacetylase 2 (HDAC2) andμ-opioid recepter (MOR) in 
   dorsal root ganglia (DRG) of bone cancer pain-morphine tolerance (BCP-MT) rats, 
   and to explore its possible mechanism. METHODS: A total of 35 SD rats were 
   randomized into a sham BCP group (n=6), a BCP group (n=7), a MT group (n=7), a 
   BNA+EA group (n=8) and a shame BNA group (n=7). Except of the sham BCP group, 
   cancer cell inoculation operation at left tibia was given in the other 4 groups 
   to establish the bone cancer pain model. In the MT group, the BNA+EA group and 
   the shame BNA group, intraperitoneal injection of morphine hydrochloride was 
   given to establish the morphine tolerance model. After the operation, bone-nearby 
   acupuncture combined with electroacupuncture was applied at "Zusanli" (ST 36) and 
   "Kunlun" (BL 60) in the BNA+EA group, with dilatational wave, 2 Hz/100 Hz in 
   frequency, 0.5 to 1.5 mA in intensity. Intervention in the shame BNA group was 
   applied at the same time and acupoints as those in the BNA+EA group, the needles 
   were pierced the skin without any electrical stimulation. The needles were 
   retained for 30 min, once a day for continuous 7 days in both BNA+EA and shame 
   BNA groups. Before and 10, 11, 15, 22 days after the operation, the left paw 
   withdrawal threshold (PWT) was measured in the 5 groups. The levels of HDAC1, 
   HDAC2 and MOR in DRG were detected by Western blot. RESULTS: Ten days after the 
   cancer cell inoculation operation, the PWT of the BCP, MT, BNA+EA and sham BNA 
   groups was decreased compared with the sham BCP group (P<0.01). Eleven days after 
   the operation, the PWT of the MT, BNA+EA and sham BNA groups was increased 
   compared with the BCP group (P<0.01). Twenty-two days after the operation, the 
   difference was no significant between the BCP group and MT group (P>0.05); the 
   PWT of the BNA+EA group was increased compared with the MT and sham BNA group 
   (P<0.01). In the BCP group, the DRG levels of HDAC1 and HDCA2 were increased, 
   while the level of MOR was decreased compared with the sham BCP group (P<0.05, 
   P<0.01). In the MT group, the DRG level of HDAC1 was increased compared with the 
   BCP group (P<0.05). In the BNA+EA group, the DRG level of HDAC1 was decreased 
   compared with the MT group and the sham BNA group (P<0.01, P<0.05), while the 
   level of MOR was increased (P<0.01). CONCLUSION: Early intervention of 
   bone-nearby acupuncture combined with electroacupuncture can relieve the morphine 
   tolerance in bone cancer pain rats, it may relate to down-regulating the 
   expression of HDAC1 and up-regulating the expression of MOR in the dorsal root 
   ganglia.
C1 Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China
   Department of Acupuncture and Moxibustion, First AffiliatedHospital of Jiaxing University, Jiaxing 314001, Zhejiang Province.
   Third Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang Key Laboratory of Acupuncture and Moxibustion Neurology Research, Hangzhou 310053.
   Department of Acupuncture and Moxibustion, First Affiliated Hospital of Jiaxing University, Jiaxing 314001, Zhejiang Province.
   Third Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang Key Laboratory of Acupuncture and Moxibustion Neurology Research, Hangzhou 310053.
   Third Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang Key Laboratory of Acupuncture and Moxibustion Neurology Research, Hangzhou 310053.
   Third Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang Key Laboratory of Acupuncture and Moxibustion Neurology Research, Hangzhou 310053.
   Third Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang Key Laboratory of Acupuncture and Moxibustion Neurology Research, Hangzhou 310053.
   Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China
   Department of Acupuncture and Moxibustion, First AffiliatedHospital of Jiaxing University, Jiaxing 314001, Zhejiang Province.
   Third Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang Key Laboratory of Acupuncture and Moxibustion Neurology Research, Hangzhou 310053.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD APR 11
PY 2020
VL 40
IS 4
BP 405
EP 10
DI 10.13703/j.0255-2930.20190822-k0002 
PG -395
WC Acupuncture Points; Animals; Bone Neoplasms; complications; Cancer Pain; therapy; Drug Tolerance; Electroacupuncture; Ganglia, Spinal; metabolism; Histone Deacetylases; metabolism; Morphine; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; metabolism
UT PubMed:32275370
PM 32275370
DA 2020-04-11
ER

PT J
AU Lu, DR
   Xia, YQ
   Chen, F
   Wang, NJ
   He, SQ
   Wang, F
   Zhu, SJ
AF Lu, Dian-Rong
   Xia, Yu-Qing
   Chen, Feng
   Wang, Ning-Jun
   He, Sheng-Qi
   Wang, Fang
   Zhu, Shi-Jie
TI [Effect of electrothermal acupuncture on moderate to severe cancer pain with 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE electrothermal acupuncture; moderate to severe cancer pain; pain remission rate; yin-cold stagnation
AB OBJECTIVE: To observe the effectiveness and safety of electrothermal acupuncture 
   therapy for patients of moderate to severe cancer pain with yin-cold stagnation. 
   METHODS: A total of 60 patients of moderate to severe cancer pain with yin-cold 
   stagnation were randomized into an observation group and a control group, 30 
   cases in each one. In the control group, opioid painkillers (oxycodone 
   hydrochloride prolonged-release tablet or morphine sulfate sustained-release 
   tablet) were taken. On the basis of the control group, electrothermal acupuncture 
   was applied at Guanyuan (CV 4), Qihai (CV 6), Zusanli (ST 36), Hegu (LI 4), 
   Sanyinjiao (SP 6) in the observation group, 30 min each treatment, once a day for 
   5 days. Before and after treatment, the scores of pain numerical rating scale 
   (NRS) and Karnofsky performance scale (KPS) were observed in the two groups. The 
   pain remission rate, reduction of opioid painkillers and safety were compared. 
   RESULTS: The variation of NRS scores in the observation group were larger than 
   the control group 3, 5 days into treatment (P<0.01, P<0.05). The variation of KPS 
   score in the observation group was larger than the control group after treatment 
   (P<0.05). The pain remission rate was 100.0% (30/30) in the observation group, 
   higher than 86.7% (26/30) in the control group (P<0.05). The reduction of opioid 
   painkillers in the observation group was larger than the control group (P<0.01). 
   There was no adverse reaction during the treatment in the two groups. CONCLUSION: 
   On the basis of the conventional western medication for analgesia, electrothermal 
   acupuncture could relieve pain, reduce the dose of opioid painkillers and improve 
   the quality of life in patients of moderate to severe cancer pain with yin-cold 
   stagnation, has a better safety.
C1 Department of Oncology, China Academy of Chinese Medical Sciences, Beijing 100102, China.
   Department of Electrothermal Acupuncture, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
   Department of Acupuncture and Moxibustion, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
   Department of Oncology, China Academy of Chinese Medical Sciences, Beijing 100102, China.
   Department of Oncology, China Academy of Chinese Medical Sciences, Beijing 100102, China.
   Department of Oncology, China Academy of Chinese Medical Sciences, Beijing 100102, China.
   Department of Oncology, China Academy of Chinese Medical Sciences, Beijing 100102, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD APR 1
PY 2021
VL 41
IS 2
BP 121
EP 4
DI 10.13703/j.0255-2930.20190320-0010 
PG -117
WC Acupuncture Points; Acupuncture Therapy; Cancer Pain; therapy; Humans; Neoplasms; complications; Oxycodone; Quality of Life; Treatment Outcome
UT PubMed:33788457
PM 33788457
DA 2021-04-01
ER

PT J
AU Benson, S
   Hagen, S
   Hoffmann, O
   Pasler, A
   Bingel, U
   Schedlowski, M
   Peters, J
   Elsenbruch, S
   Frey, UH
AF Benson, Sven
   Hagen, Susanne
   Hoffmann, Oliver
   Pasler, Annika
   Bingel, Ulrike
   Schedlowski, Manfred
   Peters, Jürgen
   Elsenbruch, Sigrid
   Frey, Ulrich H
TI Can a brief psychological expectancy intervention improve postoperative pain? A 
SO Pain
LA English
DT Journal Article
AB Pain after surgery remains a major health problem, calling for optimized 
   treatment regimens to maximize the efficacy of pharmacological interventions. In 
   this randomized controlled trial, we tested in a routine surgical treatment 
   setting whether postoperative pain can be reduced by a brief preoperative 
   intervention, ie, positive verbal suggestions in combination with sham 
   acupuncture, designed to optimize treatment expectations. We hypothesized that 
   the expectancy intervention as add-on to patient-controlled intravenous analgesia 
   with morphine reduces patient-reported postoperative pain and improves 
   satisfaction with analgesia. Ninety-six women undergoing breast cancer surgery 
   were randomized at 2 stages: Before surgery, anesthesiologists delivered either 
   positive or neutral verbal suggestions regarding the benefits of acupuncture 
   needling on postoperative pain ("information condition"). Patients were then 
   randomized to receive sham acupuncture or no sham acupuncture during 
   postoperative care ("sham acupuncture condition"). Average pain during the 
   24-hour observation period after surgery as primary and satisfaction with 
   analgesia as secondary outcome was assessed with standardized measures and 
   analyzed with analysis of covariance accounting for morphine dose, 
   surgery-related, and psychological parameters. Postoperative pain ratings were 
   significantly reduced in patients who received positive treatment-related 
   suggestions (F = 4.45, P = 0.038, main effect of information). Moreover, patients 
   who received an intervention aimed at optimized treatment expectations reported 
   significantly greater satisfaction with analgesia (F = 4.89, P = 0.030, 
   interaction effect). Together, our proof-of-concept data support that optimizing 
   treatment expectations through verbal suggestions may offer a promising approach 
   to improve patient-reported outcomes. Future translational and clinical studies 
   are needed to test such psychological strategies in different surgical 
   interventions, patient groups, and pharmacological treatment regimens.
C1 Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
   Klinik für Anästhesiologie und Intensivmedizin, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
   Clinic for Obstetrics and Gynecology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
   Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
   Klinik für Anästhesiologie und Intensivmedizin, University Hospital Essen, 
   Clinic for Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
   Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
   Klinik für Anästhesiologie und Intensivmedizin, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
   Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
   Klinik für Anästhesiologie und Intensivmedizin, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
   Department of Anesthesiology, Marienhospital Herne, Ruhr University Bochum, 
NR 0
TC 0
SN 1872-662
EI 
J9 Pain
PD MAR 7
PY 2019
VL 160
IS 7
BP 1562
EP 1571
DI 10.1097/j.pain.0000000000001546 
PG 9
WC Acupuncture Therapy; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; therapeutic use; Breast Neoplasms; surgery; Double-Blind Method; Female; Humans; Middle Aged; Morphine; therapeutic use; Pain Management; Pain Measurement; Pain, Postoperative; drug therapy; Patient Satisfaction; Psychotherapy, Brief; methods; Socioeconomic Factors; Treatment Outcome; Young Adult
UT PubMed:30839426
PM 30839426
DA 2019-03-07
ER

PT J
AU Wu, M
   Tang, Q
   Gao, W
   Zhu, L
AF Wu, Minmin
   Tang, Qiang
   Gao, Weibin
   Zhu, Luwen
TI Electroacupuncture for acute transverse myelitis following viral infection: A 
SO Explore (New York, N.Y.)
LA English
DT Journal Article
DE Acute transverse myelitis; Case report; Electroacupuncture; Functional recovery
AB BACKGROUND: Electroacupuncture (EA) has a positive effect on neurological repair 
   and functional recovery following spinal cord disease. However, evidence of its 
   effectiveness in acute transverse myelitis (ATM) cases is limited. PATIENT 
   PRESENTATION: A 48-year-old woman experienced headache and fever for 5 days, 
   followed by a sudden onset of back pain, lower limb paralysis, and urinary and 
   bowel dysfunction. The patient received intravenous medications. However, she did 
   not experience improvement in clinical symptoms. She subsequently underwent 
   acupuncture treatment. She regained walking ability and experienced improved 
   bladder function and bowel control after 36 sessions of EA treatment. METHODS: 
   CARE guidelines informed the case study report. The MRC and ICIQ-UI-SF scores 
   were used to verify changes in lower-extremity muscle strength and urination 
   after EA treatment. Qualitative information was collected using feedback tables. 
   CONCLUSION: Pharmacological treatment for ATM lacks clear advantages because of 
   its complex pathophysiological mechanisms. Hence, EA could be recommended as a 
   promising treatment modality for ATM.
C1 Department of Rehabilitation Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
   The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, 411 Guogeli Street, Nangan District, Harbin, Heilongjiang 150000, China.
   The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, 411 Guogeli Street, Nangan District, Harbin, Heilongjiang 150000, China.
   The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, 411 Guogeli Street, Nangan District, Harbin, Heilongjiang 150000, China.
EM zhuluwen1983@126.com
NR 0
TC 0
SN 1878-754
EI 
J9 Explore (NY)
PD DEC 2
PY 2023
VL 20
IS 4
BP 597
EP 601
DI 10.1016/j.explore.2023.11.012 
PG 4
WC Humans; Female; Electroacupuncture; methods; Myelitis, Transverse; therapy; Middle Aged; Virus Diseases; therapy; Muscle Strength; Fever; therapy; Treatment Outcome; Back Pain; therapy
UT PubMed:38040618
PM 38040618
DA 2023-12-02
ER

PT J
AU Han, XR
   Yue, W
   Chen, HC
   He, W
   Luo, JH
   Chen, SX
   Liu, N
   Yang, M
AF Han, Xin-Rui
   Yue, Wei
   Chen, Hui-Chao
   He, Wei
   Luo, Jiang-He
   Chen, Shan-Xia
   Liu, Na
   Yang, Ming
TI Treatment duration of wrist-ankle acupuncture for relieving post-thyroidectomy 
SO Journal of integrative medicine
LA English
DT Journal Article
DE Post-operative pain; Randomized controlled trial; Thyroid tumor; Thyroidectomy; Wrist-ankle acupuncture
AB BACKGROUND: Treatment duration of wrist-ankle acupuncture (WAA) is uncertain for 
   post-thyroidectomy pain relief. OBJECTIVE: This study evaluated the effect of 
   different WAA treatment duration on post-operative pain relief and other 
   discomforts associated with thyroidectomy. DESIGN, SETTING, PARTICIPANTS AND 
   INTERVENTION: This randomized controlled trial was conducted at a single research 
   site in Guangzhou, China. A total of 132 patients receiving thyroidectomy were 
   randomly divided into the control group (sham WAA, 30 min) and three intervention 
   groups (group 1: WAA, 30 min; group 2: WAA, 45 min; group 3: WAA, 60 min), with 
   group allocation ratio of 1:1:1:1. Acupuncture was administered within 1 hour of 
   leaving the operating room. OUTCOMES AND MEASURES: Primary outcome was patients' 
   pain at the surgical site assessed by visual analogue scale (VAS) at the moment 
   after acupuncture treatment (post-intervention). Secondary outcomes included the 
   patients' pain VAS scores at 6, 12, 24, 48 and 72 h after the thyroidectomy, the 
   40-item Quality of Recovery (QoR-40) score, the grade of post-operative nausea 
   and vomiting (PONV), and the use of additional analgesic therapy. RESULTS: The 
   adjusted mean difference (AMD) in VAS scores from baseline to post-intervention 
   in group 1 was -0.89 (95% confidence interval [CI], -1.02 to -0.76). The decrease 
   in VAS score at post-intervention was statistically significant in group 1 
   compared to the control group (AMD, -0.43; 95% CI, -0.58 to -0.28; P < 0.001), 
   and in groups 2 and 3 compared to group 1 (group 2 vs group 1: AMD, -0.65; 95% 
   CI, -0.81 to -0.48; P < 0.001; group 3 vs group 1: AMD, -0.66; 95% CI, -0.86 to 
   -0.47; P < 0.001). The VAS scores in the four groups converged beyond 24 h after 
   the operation. Fewer patients in group 2 and group 3 experienced PONV in the 
   first 24 h after operation. No statistical differences were measured in QoR-40 
   score and the number of patients with additional analgesic therapy. CONCLUSION: 
   Compared with the 30 min intervention, WAA treatment with longer needle retention 
   time (45 or 60 min) had an advantage in pain relief within 6 h after surgery. 
   WAA's analgesic effect lasted for 6-12 h post-operatively. Please cite this 
   article as: Han XR, Yue W, Chen HC, He W, Luo JH, Chen SX, Liu N, Yang M. 
   Treatment duration of wrist-ankle acupuncture for relieving post-thyroidectomy 
   pain: A randomized controlled trial. J Integr Med. 2023; 21(2): 168-175.
C1 Department of Nursing, Chengdu Integrated TCM & Western Medicine Hospital, Sichuan 610041, Sichuan Province, China.
   School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China.
   Department of Nursing, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China.
   Department of General Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China.
   Department of Gynecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou 510120, Guangdong Province, China.
   School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China.
   School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China.
   School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China. 
EM hlym@gzucm.edu.cn
NR 0
TC 0
SN 
EI 2095-496
J9 J Integr Med
PD FEB 26
PY 2023
VL 21
IS 2
BP 168
EP 175
DI 10.1016/j.joim.2023.02.001 
PG 7
WC Male; Humans; Ankle; Wrist; Duration of Therapy; Thyroidectomy; Postoperative Nausea and Vomiting; drug therapy; Acupuncture Therapy; Analgesics; therapeutic use; Pain; drug therapy
UT PubMed:36841749
PM 36841749
DA 2023-02-26
ER

PT J
AU Liou, KT
   Hung, TKW
   Meghani, SH
   Epstein, AS
   Li, QS
   Romero, SAD
   Cohen, RB
   Mao, JJ
AF Liou, Kevin T
   Hung, Tony K W
   Meghani, Salimah H
   Epstein, Andrew S
   Li, Q Susan
   Romero, Sally A D
   Cohen, Roger B
   Mao, Jun J
TI What if Acupuncture Were Covered by Insurance for Pain Management? A 
SO Pain medicine (Malden, Mass.)
LA English
DT Journal Article
DE Access; Acupuncture; Cancer; Disparities; Health Beliefs; Insurance; Pain
AB OBJECTIVE: In response to the national opioid crisis, governmental and medical 
   organizations have called for broader insurance coverage of acupuncture to 
   improve access to nonpharmacologic pain therapies, especially in cancer 
   populations, where undertreatment of pain is prevalent. We evaluated whether 
   cancer patients would be willing to use insurance-covered acupuncture for pain. 
   DESIGN AND SETTING: We conducted a cross-sectional survey of cancer patients with 
   pain at one academic center and 11 community hospitals. METHODS: We used logistic 
   regression models to examine factors associated with willingness to use 
   insurance-covered acupuncture for pain. RESULTS: Among 634 cancer patients, 304 
   (47.9%) reported willingness to use insurance-covered acupuncture for pain. In 
   univariate analyses, patients were more likely to report willingness if they had 
   severe pain (odds ratio [OR] = 1.59, 95% confidence interval [CI] = 1.03-2.45) 
   but were less likely if they were nonwhite (OR = 0.59, 95% CI = 0.39-0.90) or had 
   only received high school education or less (OR = 0.46, 95% CI = 0.32-0.65). 
   After adjusting for attitudes and beliefs in multivariable analyses, willingness 
   was no longer significantly associated with education (adjusted OR [aOR] = 0.78, 
   95% CI = 0.50-1.21) and was more negatively associated with nonwhite race (aOR = 
   0.49, 95% CI = 0.29-0.84). CONCLUSIONS: Approximately one in two cancer patients 
   was willing to use insurance-covered acupuncture for pain. Willingness was 
   influenced by patients' attitudes and beliefs, which are potentially modifiable 
   through counseling and education. Further research on racial disparities is 
   needed to close the gap in utilization as acupuncture is integrated into 
   insurance plans in response to the opioid crisis.
C1 Bendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Hematology-Oncology, Olive View-UCLA Medical Center, Sylmar, California.
   Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Medicine, Weill Cornell Medical College, New York, New York.
   Bendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, New York, New York.
   Bendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, New York, New York.
   Division of Hematology-Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
   Bendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, New York, New York.
   Department of Medicine, Weill Cornell Medical College, New York, New York.
NR 0
TC 0
SN 1526-463
EI 1526-237
J9 Pain Med
PD JUL 23
PY 2019
VL 20
IS 10
BP 2060
EP 2068
DI 10.1093/pm/pnz087 
PG 8
WC Academic Medical Centers; statistics & numerical data; Acupuncture Therapy; Adult; Cancer Pain; economics; Cross-Sectional Studies; Educational Status; Ethnicity; Female; Hospitals, Community; statistics & numerical data; Humans; Insurance Coverage; economics; Male; Middle Aged; Pain Management; economics; Socioeconomic Factors; Surveys and Questionnaires
UT PubMed:31329938
PM 31329938
DA 2019-07-23
ER

PT J
AU Zhang, W
   Xu, J
   Wan, Y
   Yang, M
   Huang, J
AF Zhang, Weina
   Xu, Jingnan
   Wan, Yuxiang
   Yang, Ming
   Huang, Jinchang
TI Moxibustion combined with guasha therapy for recurrent neutropenia following 
SO Explore (New York, N.Y.)
LA English
DT Journal Article
DE Case report; Chemotherapy-induced myelosuppression; Guasha therapy; Moxibustion; Neutropenia
AB Neutropenia, a common side effect of chemotherapy for ovarian cancer, was 
   observed in a 47-year-old female patient undergoing a six-cycle chemotherapy 
   regimen. She experienced recurrent neutropenia and leukopenia but refused 
   granulocyte colony-stimulating factor (G-CSF) due to severe bone pain and high 
   costs. Moxibustion combined with guasha therapy (MGT) was administered each time 
   neutropenia occurred. The treatment involved guasha therapy on the bladder 
   meridian (BL) and the governor vessel (GV), followed by moxibustion at Zhongwan 
   (CV 12), Guanyuan (CV 4), and Shenzhu (GV 12) points over 2-3 days. This approach 
   led to the recovery of neutrophil and leukocyte counts, enabling the patient to 
   complete six chemotherapy cycles without G-CSF. These findings suggest that MGT 
   may enhance neutrophil and leukocyte counts in patients with chemotherapy-induced 
   myelosuppression, presenting a potential alternative for those intolerant to 
   G-CSF. However, further high-quality research is needed to confirm its efficacy.
C1 The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, 100029, China.
   The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, 100029, China.
   The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, 100029, China.
   The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, 100029, China.
   The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, 100029, China. 
EM zryhhuang@163.com
NR 0
TC 0
SN 1878-754
EI 
J9 Explore (NY)
PD JUL 11
PY 2024
VL 20
IS 5
BP 103031
EP 103031
DI 10.1016/j.explore.2024.103031 
PG 0
WC Humans; Female; Middle Aged; Neutropenia; therapy; Ovarian Neoplasms; drug therapy; Moxibustion; methods; Antineoplastic Combined Chemotherapy Protocols; adverse effects; Leukocyte Count; Neutrophils; Combined Modality Therapy; Recurrence
UT PubMed:38986288
PM 38986288
DA 2024-07-11
ER

PT J
AU Dommerholt, J
   Thorp, JN
   Chou, LW
   Hooks, T
AF Dommerholt, Jan
   Thorp, Jacob N
   Chou, Li-Wei
   Hooks, Todd
TI A critical overview of the current myofascial pain literature - January 2020.
SO Journal of bodywork and movement therapies
LA English
DT Editorial
DE Dry needling; Manual therapy; Myofascial pain syndrome; Trigger points
AB We are starting 2020 with 6 basic research studies, 9 review articles, 14 dry 
   needling/injection studies, and one manual therapy paper for a total of 30 new 
   papers. Topics range from studies on mechanisms, inflammatory mediators in 
   myofascial pain, fascia, screening, Platelet-rich plasma intramuscular 
   injections, and temporal summation to clinical studies on patients with 
   tension-type headache, chronic pelvic pain, knee osteoarthritis, plantar 
   fasciitis, generalized musculoskeletal pain, neck pain, breast cancer, 
   tendinopathies, thoracic outlet syndrome, and canine dry needling, among others.
C1 Bethesda Physiocare, Bethesda, MD, USA
   Myopain Seminars, Bethesda, MD, USA. 
   Myopain Seminars, Bethesda, MD, USA
   Charleston Southern University, North Charleston, SC, USA. 
   China Medical University, Taichung, Taiwan. 
   Myopain Seminars, Bethesda, MD, USA
   New Orleans Pelicans, New Orleans, LA, USA. 
EM trhooks@hotmail.com
NR 0
TC 0
SN 1532-928
EI 
J9 J Bodyw Mov Ther
PD JUN 9
PY 2020
VL 24
IS 2
BP 213
EP 224
DI 10.1016/j.jbmt.2020.04.001 
PG 11
WC Acupuncture Therapy; Animals; Dogs; Humans; Musculoskeletal Manipulations; Myofascial Pain Syndromes; therapy; Neck Pain; Trigger Points
UT PubMed:32507147
PM 32507147
DA 2020-06-09
ER

PT J
AU Lukkahatai, N
   Benjasirisan, C
   Shen, A
   Li, J
   Allgood, S
   Thomas, F
   Karyukin, A
   Sheng, JY
   Engle, J
   Lee, TY
   Saligan, LN
AF Lukkahatai, Nada
   Benjasirisan, Chitchanok
   Shen, Aomei
   Li, Junxin
   Allgood, Sarah
   Thomas, Frank
   Karyukin, Artyom
   Sheng, Jennifer Y
   Engle, Jessica
   Lee, Ta-Ya
   Saligan, Leorey N
TI Combined technology-enhanced home exercise and acupressure (TEHEplus) program on 
SO BMC cancer
LA English
DT Journal Article
DE Acupressure; Cancer; Exercise; Immunotherapy; Mobile health
AB BACKGROUND: Cancer patients receiving immunotherapy often experience symptoms 
   impacting their well-being. The present study aimed to develop and test the 
   feasibility of a 12-week Technology-Enhanced Home Exercise and acupressure 
   (TEHEplus) program to improve symptoms (fatigue, pain, sleep, anxiety, 
   depression), social functioning, physical performance, and serum biomarkers 
   (brain-derived neurotrophic factor, heat shock protein 90 levels.) METHODS: A 
   two-phase design was employed. Phase 1 involved program development; Phase 2 was 
   a pilot feasibility study. Participants with solid tumor cancers were recruited 
   from cancer centers in Maryland and randomly assigned to four groups: Usual Care 
   Control (UC), Technology-Enhanced Home Exercise (TEHE) alone, Acupressure alone 
   (ACU), and TEHEplus. Feasibility was measured by enrollment duration, 
   intervention adherence, and daily survey response rates. Outcomes were measured 
   at baseline and program completion. RESULTS: In phase 1, four participants (age 
   56-82) provided feedback on online training, smartphone application, intervention 
   duration, and outcome measures. In Phase 2, 40 participants (10 per group) were 
   recruited over 12 months, with 43% (n = 17) completing all daily surveys. 
   TEHEplus participants achieved 50% of exercise goals, and 78% adhered to the 
   acupoint recommendations. TEHEplus participants showed significant improvements 
   in fatigue (p = 0.02), pain inference (p = 0.30), and social functioning 
   (p = 0.03); TEHE participants improved only in social functioning (p = 0.03). 
   CONCLUSION: TEHEplus is feasible and shows promise for symptom alleviation. 
   Preliminary findings suggest potential benefits in symptom management and 
   functional outcomes. However, further studies with larger and more diverse 
   samples are warranted to explore its efficacy and generalizability.Further 
   studies with larger, more diverse populations are needed to confirm its efficacy. 
   TEHEplus may enhance symptom management and improve functional outcomes for 
   cancer survivors undergoing immunotherapy. TRIAL REGISTRATION: ClinicalTrials.gov 
   ID NCT03576274 Trial Registration Date: 06/07/2018.
C1 School of Nursing, Johns Hopkins University, Baltimore, MD, USA. nada.lukkahatai@jhu.edu.
   School of Nursing, Johns Hopkins University, Baltimore, MD, USA.
   Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin Medical University Ministry of Education,Tianjin, China.
   School of Nursing, Johns Hopkins University, Baltimore, MD, USA.
   School of Nursing, Johns Hopkins University, Baltimore, MD, USA.
   School of Nursing, Johns Hopkins University, Baltimore, MD, USA.
   School of Nursing, Johns Hopkins University, Baltimore, MD, USA.
   Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
   Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
   Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
   School of Nursing, Rutgers, The State University of New Jersey, Newark, NJ, USA.
NR 0
TC 0
SN 1471-240
EI 
J9 BMC Cancer
PD OCT 2
PY 2025
VL 25
IS 1
BP 1481
EP 1481
DI 10.1186/s12885-025-14887-2 
PG 0
WC Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Acupressure; methods; Exercise; Exercise Therapy; methods; Fatigue; therapy; Feasibility Studies; Immunotherapy; adverse effects; Neoplasms; therapy; Pilot Projects; Quality of Life
UT PubMed:41034793
PM 41034793
DA 2025-10-02
ER

PT J
AU Liu, SR
   Qiu, JQ
   Zhang, LY
   Lin, QL
   Ye, GP
   Zhu, DY
AF Liu, Shu-Ru
   Qiu, Jian-Qing
   Zhang, Lin-Yun
   Lin, Qian-Lin
   Ye, Guo-Ping
   Zhu, Ding-Yu
TI [Warming acupuncture combined with moxibustion at Yongquan (KI 1) for knee 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE Point KI 1 (Yongquan); kidney-marrow deficiency; knee osteoarthritis; moxibustion; randomized controlled trial (RCT); warming acupuncture
AB OBJECTIVE: To compare the clinical effect between warming acupuncture combined 
   with moxibustion at Yongquan (KI 1) and simple warming acupuncture for knee 
   osteoarthritis with kidney-marrow deficiency. METHODS: A total of 66 patients of 
   knee osteoarthritis with kidney-marrow deficiency were randomized into an 
   observation group and a control group, 33 cases in each one. Warming acupuncture 
   was applied at Neixiyan (EX-LE 4), Dubi (ST 35), Zusanli (ST 36) and Xuanzhong 
   (GB 39) on the affected side in both of the groups. In the observation group, 
   mild moxibustion at bilateral Yongquan (KI 1) was adopted additionally. Each 
   treatment lasted for 30 min, 3 times a week (once every other day), and the 
   consecutive 6 weeks of treatment were required. The Western Ontario and McMaster 
   Universities Osteoarthritis Index (WOMAC) score (such as joint pain, stiffness 
   and physical function), the amount of joint effusion and the serum contents of 
   interleukin-1β(IL-1β), tumor necrosis factor-α (TNF-α) and high-sensitivity 
   C-reactive protein (hs-CRP) were observed before and after treatment in the two 
   groups. RESULTS: The total effective rate in the observation group was 93.3% 
   (28/30), which was superior to 87.1% (27/30) in the control group (P<0.05). 
   Compared before treatment, the pain scores, stiffness scores, physical function 
   scores, the amount of joint effusion and the contents of IL-1β, TNF-α and hs-CRP 
   after treatment were significantly reduced in the two groups (P<0.05), and the 
   improvements of these indices in the observation group were superior to the 
   control group (P<0.05). CONCLUSION: Warming acupuncture combined with moxibustion 
   at Yongquan (KI 1) can improve joint function, reduce the amount of joint 
   effusion and the contents of inflammatory response indices for knee 
   osteoarthritis with kidney-marrow deficiency. The therapeutic effect of warming 
   acupuncture combined with moxibustion at Yongquan (KI 1) is better than simple 
   warming acupuncture.
C1 School of Acupuncture and Moxibustion, Fujian University of CM, Fuzhou 350122, China.
   School of Acupuncture and Moxibustion, Fujian University of CM, Fuzhou 350122, China.
   Department of Acupuncture and Moxibustion, Second People's Hospital Affilated to Fujian University of CM, Fuzhou 350003.
   Department of Acupuncture and Moxibustion, Second People's Hospital Affilated to Fujian University of CM, Fuzhou 350003.
   School of Acupuncture and Moxibustion, Fujian University of CM, Fuzhou 350122, China.
   Department of Acupuncture and Moxibustion, Second People's Hospital Affilated to Fujian University of CM, Fuzhou 350003.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD AUG 10
PY 2019
VL 39
IS 8
BP 799
EP 803
DI 10.13703/j.0255-2930.2019.08.001 
PG 4
WC Acupuncture Points; Acupuncture Therapy; Bone Marrow; Humans; Moxibustion; Osteoarthritis, Knee; therapy; Treatment Outcome
UT PubMed:31397121
PM 31397121
DA 2019-08-10
ER

PT J
AU Wu, JW
   Li, LP
   Chen, YS
AF Wu, Jing-Wen
   Li, Li-Ping
   Chen, Yin-Song
TI Effects of bottle gourd moxibustion combined with umbilical therapy for 
SO World journal of gastroenterology
LA English
DT Journal Article
DE Bottle gourd moxibustion; Cancer-induced bowel obstruction; Gastrointestinal recovery; Inflammatory cytokines; Pain management; Umbilical therapy
AB BACKGROUND: Cancer-induced incomplete bowel obstruction presents numerous 
   clinical challenges, notably pain management and inflammation control. 
   Conventional therapies provide limited relief, prompting investigation into 
   complementary approaches. This study compares the efficacy of bottle gourd 
   moxibustion combined with umbilical therapy (BGM-UT) plus standard palliative 
   care vs standard Western palliative care alone in symptom alleviation and 
   inflammation reduction. AIM: To compare the efficacy of BGM-UT plus standard 
   palliative care vs standard palliative care alone in reducing inflammatory 
   cytokine levels, alleviating symptoms, and improving gastrointestinal recovery in 
   cancer-induced incomplete bowel obstruction. METHODS: A retrospective analysis 
   was conducted on 109 patients aged 18-75 years with cancer-induced incomplete 
   bowel obstruction treated at the Foshan Hospital of Traditional Chinese Medicine 
   between October 2023 and September 2024. The participants were categorized into 
   two groups: (1) Regular group receiving standard palliative care; and (2) BGM-UT 
   group receiving additional moxibustion therapy. The inclusion criteria included 
   ongoing opioid use and a Karnofsky performance status score below 60. The 
   treatments were evaluated for 3 weeks in terms of opioid consumption, 
   gastrointestinal function recovery, brief pain inventory scores, traditional 
   Chinese medicine symptom scores, and inflammatory cytokine levels. RESULTS: 
   Initially, the groups were demographically and clinically comparable. 
   Post-treatment, the BGM-UT group showed significant reductions in opioid intake 
   (P = 0.027), improved gastrointestinal recovery times, and enhanced pain 
   management as reflected by their lower brief pain inventory scores (P < 0.05). 
   Similarly, the improvement in traditional Chinese medicine scores was greater in 
   the BGM-UT group than in the regular group (P < 0.05). Inflammatory markers 
   including interleukin-6, tumor necrosis factor-α, and C-reactive protein 
   decreased significantly in the BGM-UT group, indicating the superior 
   anti-inflammatory effects of this treatment (P < 0.05). CONCLUSION: The addition 
   of BGM-UT to standard palliative care enhances pain relief, accelerates 
   gastrointestinal recovery, and effectively reduces inflammatory cytokine levels 
   in patients with cancer-induced incomplete bowel obstruction. This combination 
   therapy offers a promising complementary approach to managing this challenging 
   condition. Further prospective studies are warranted to validate these findings 
   and explore underlying mechanisms.
C1 Department of Oncology, Foshan Hospital of Traditional Chinese Medicine, The Eighth Clinical Medical College, Guangzhou University of Chinese Medicine, Foshan528000, Guangdong Province, China.
   Department of Oncology, Foshan Hospital of Traditional Chinese Medicine, The Eighth Clinical Medical College, Guangzhou University of Chinese Medicine, Foshan528000, Guangdong Province, China. 13794038664@163.com.
   Department of Oncology, Foshan Hospital of Traditional Chinese Medicine, The Eighth Clinical Medical College, Guangzhou University of Chinese Medicine, Foshan528000, Guangdong Province, China.
NR 0
TC 0
SN 2219-284
EI 1007-932
J9 World J Gastroenterol
PD NOV 19
PY 2025
VL 31
IS 41
BP 110753
EP 110753
DI 10.3748/wjg.v31.i41.110753 
PG 0
WC Humans; Moxibustion; methods; Middle Aged; Male; Female; Retrospective Studies; Palliative Care; methods; Intestinal Obstruction; therapy; Adult; Aged; Neoplasms; complications; Cytokines; blood; Treatment Outcome; Combined Modality Therapy; methods; Young Adult; Pain Measurement; Adolescent; Pain Management; methods; Medicine, Chinese Traditional; methods
UT PubMed:41257282
PM 41257282
DA 2025-11-19
ER

PT J
AU Zeng, J
   Zhou, R
   Luo, Z
   Zhang, N
   Liu, Z
   Lin, G
AF Zeng, Jingchun
   Zhou, Runjin
   Luo, Zhenke
   Zhang, Na
   Liu, Zijun
   Lin, Guohua
TI Clinical evidence of acupuncture and related therapy in patients with 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Cancer pain (CP) is one of the common complications of cancer. During 
   the treatment, oral medication, radiotherapy and chemotherapy bring certain 
   adverse reactions to patients with CP; a safe way to treat this disease is 
   necessary. Acupuncture and related therapies for CP with few side effects have 
   been gradually accepted. But at present the evidence is insufficient, the related 
   research is not thorough enough. The purpose of this study was to investigate the 
   efficacy and safety of acupuncture and related therapies for CP. METHODS: The 
   Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 
   (PRISMA-P) guidelines were used to design this protocol. The final study will 
   also be conducted under the PRISMA guidelines for systematic reviews and 
   meta-analysis. An electronic search will be conducted in Medline, Embase, and the 
   Cochrane Central Register of Controlled Trials databases through January 2020. 
   The search will be conducted in English. Risk of bias will be assessed by the 
   Cochrane Collaboration tool and the collected evidence will be nar-ratively 
   synthesized. We will also perform a meta-analysis to pool estimates from studies 
   considered to be homogenous. Subgroup analyses will be based on intervention or 
   overall bias. The strength of evidence will be evaluated by the Grading of 
   Recommendations, Assessment, Development and Evaluation scale. RESULTS: This 
   systematic review will summarize high quality clinical evidence to assess and 
   appraise the effectiveness and safety of acupuncture and related therapies for CP 
   patients. CONCLUSION: The meta-analysis will assess evidence from randomized 
   controlled trials of acupuncture and related therapies and CP types. INPLASY 
   REGISTRATION NUMBER: INPLASY202040129.
C1 Department of Acupuncture, The First Affiliated Hospital, Guangzhou University of Chinese Medicine.
   Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
   Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
   Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
   Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
   Department of Acupuncture, The First Affiliated Hospital, Guangzhou University of Chinese Medicine.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD NOV 8
PY 2020
VL 99
IS 45
BP e23119
EP e23119
DI 10.1097/MD.0000000000023119 
PG 1
WC Acupuncture Therapy; adverse effects; Cancer Pain; therapy; Humans; Research Design; Systematic Reviews as Topic; Treatment Outcome
UT PubMed:33157988
PM 33157988
DA 2020-11-08
ER

PT J
AU Lukkahatai, N
   Nguyen, MV
   Zhang, J
   Cho, YM
   Benjasirisan, C
   Jia, HM
   Campbell, CM
   Kawi, J
   Wu, H
   Wang, H
   Bora, R
   Thrul, J
   Johnson, CM
   Smith, TJ
AF Lukkahatai, Nada
   Nguyen, Michael V
   Zhang, Jingyu
   Cho, Yu-Min
   Benjasirisan, Chitchanok
   Jia, Heijingzi Monica
   Campbell, Claudia M
   Kawi, Jennifer
   Wu, Hulin
   Wang, Hongyu
   Bora, Rupsikha
   Thrul, Johannes
   Johnson, Constance M
   Smith, Thomas J
TI A randomized controlled study of auricular point acupressure to manage 
SO PloS one
LA English
DT Journal Article
AB OBJECTIVE: Chemotherapy-induced neuropathy (CIN) significantly impacts cancer 
   patients, leading to functional disability, diminished quality of life, and 
   increased healthcare costs amid the ongoing opioid crisis. Auricular point 
   acupressure (APA), a non-invasive and non-pharmacological alternative, has shown 
   potential for alleviating the pain, numbness, and tingling associated with CIN. 
   This study aims to assess the efficacy of APA for CIN symptoms and physical 
   function and to examine the mechanisms underlying APA's effects on CIN. METHODS: 
   This is a three-arm randomized controlled clinical trial protocol. Patients aged 
   18 and older who are experiencing CIN are randomly assigned to one of the three 
   groups: an APA group (in-person APA; mAPA), a sham control group (virtual APA; 
   vAPA), and a wait-list usual care control group (UC). During the four-week 
   program, participants in the mAPA receive an in-person APA treatment and 
   training; the sham control participants (vAPA) receive a self-guided smartphone 
   APA application with APA demonstration videos; and the UC participants will 
   continue with the usual care and be re-randomized into one of the APA groups. The 
   primary outcomes are changes in CIN symptoms and physical function. Secondary 
   outcomes include evaluating pain sensory thresholds, motor and cognitive 
   functioning, inflammatory signaling, brain connectivity, opioid use, and quality 
   of life. The outcomes are measured at baseline, program completion (4 weeks), and 
   at monthly follow-up for 3 months post-intervention. DISCUSSION: This study will 
   provide evidence supporting the potential viability of APA as an intervention for 
   CIN. TRIAL REGISTRATION: ClinicalTrials.gov, ID NCT04920097 registered on 3 June 
   2021.
C1 Johns Hopkins University School of Nursing, Baltimore, MD, United States of America.
   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, United 
   The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, United States of America.
   Johns Hopkins University School of Nursing, Baltimore, MD, United States of America.
   The University of Texas Health Science Center at Houston, Cizik School of Nursing, Houston, TX, United States of America.
   Johns Hopkins University School of Nursing, Baltimore, MD, United States of America.
   Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
   Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
   The University of Texas Health Science Center at Houston, Cizik School of Nursing, Houston, TX, United States of America.
   The University of Texas Health Science Center at Houston, School of Public Health, Houston, TX, United States of America.
   The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, United States of America.
   The University of Texas Health Science Center at Houston, Cizik School of 
   The University of Texas Health Science Center at Houston, Cizik School of Nursing, Houston, TX, United States of America.
   Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
   The University of Texas Health Science Center at Houston, Cizik School of Nursing, Houston, TX, United States of America.
   Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
NR 0
TC 0
SN 1932-620
EI 
J9 PLoS One
PD SEP 26
PY 2024
VL 19
IS 9
BP e0311135
EP e0311135
DI 10.1371/journal.pone.0311135 
PG 1
WC Adult; Female; Humans; Male; Middle Aged; Acupressure; methods; Antineoplastic Agents; adverse effects; Neoplasms; drug therapy; Peripheral Nervous System Diseases; therapy; Quality of Life; Randomized Controlled Trials as Topic
UT PubMed:39325795
PM 39325795
DA 2024-09-26
ER

PT J
AU Ding, YY
   Xu, F
   Wang, YF
   Han, LL
   Huang, SQ
   Zhao, S
   Ma, LL
   Zhang, TH
   Zhao, WJ
   Chen, XD
AF Ding, Yuan-Yuan
   Xu, Feng
   Wang, Ya-Feng
   Han, Lin-Lin
   Huang, Shi-Qian
   Zhao, Shuai
   Ma, Lu-Lin
   Zhang, Tian-Hao
   Zhao, Wen-Jing
   Chen, Xiang-Dong
TI Electroacupuncture alleviates postoperative pain through inhibiting 
SO Journal of integrative medicine
LA English
DT Journal Article
DE Electroacupuncture; Inflammation; Pain; Primary sensory neurons; Stimulator of interferon genes; Type-1 interferon
AB OBJECTIVE: This work explores the impact of electroacupuncture (EA) on acute 
   postoperative pain (APP) and the role of stimulator of interferon genes/type-1 
   interferon (STING/IFN-1) signaling pathway modulation in the analgesic effect of 
   EA in APP rats. METHODS: The APP rat model was initiated through abdominal 
   surgery and the animals received two 30 min sessions of EA at bilateral ST36 
   (Zusanli) and SP6 (Sanyinjiao) acupoints. Mechanical, thermal and cold 
   sensitivity tests were performed to measure the pain threshold, and 
   electroencephalograms were recorded in the primary somatosensory cortex to 
   identify the effects of EA treatment on APP. Western blotting and 
   immunofluorescence were used to examine the expression and distribution of 
   proteins in the STING/IFN-1 pathway as well as neuroinflammation. A STING 
   inhibitor (C-176) was administered intrathecally to verify its role in EA. 
   RESULTS: APP rats displayed mechanical and thermal hypersensitivities compared to 
   the control group (P < 0.05). APP significantly reduced the amplitude of θ, α and 
   γ oscillations compared to their baseline values (P < 0.05). Interestingly, 
   expression levels of proteins in the STING/IFN-1 pathway were downregulated after 
   inducing APP (P < 0.05). Further, APP increased pro-inflammatory factors, 
   including interleukin-6, tumor necrosis factor-α and inducible nitric oxide 
   synthase, and downregulated anti-inflammatory factors, including interleukin-10 
   and arginase-1 (P < 0.05). EA effectively attenuated APP-induced painful 
   hypersensitivities (P < 0.05) and restored the θ, α and γ power in APP rats 
   (P < 0.05). Meanwhile, EA distinctly activated the STING/IFN-1 pathway and 
   mitigated the neuroinflammatory response (P < 0.05). Furthermore, STING/IFN-1 was 
   predominantly expressed in isolectin-B4- or 
   calcitonin-gene-related-peptide-labeled dorsal root ganglion neurons and 
   superficial laminae of the spinal dorsal horn. Inhibition of the STING/IFN-1 
   pathway by intrathecal injection of C-176 weakened the analgesic and 
   anti-inflammatory effects of EA on APP (P < 0.05). CONCLUSION: EA can generate 
   robust analgesic and anti-inflammatory effects on APP, and these effects may be 
   linked to activating the STING/IFN-1 pathway, suggesting that STING/IFN-1 may be 
   a target for relieving APP. Please cite this article as: Ding YY, Xu F, Wang YF, 
   Han LL, Huang SQ, Zhao S, Ma LL, Zhang TH, Zhao WJ, Chen XD. Electroacupuncture 
   alleviates postoperative pain through inhibiting neuroinflammation via stimulator 
   of interferon genes/type-1 interferon pathway. J Integr Med. 2023; 21(5): 
   496-508.
C1 Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
   Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
   Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
   Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
   Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
   Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
   Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
   Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
   Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
   Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
EM xdchen@hust.edu.cn
NR 0
TC 0
SN 
EI 2095-496
J9 J Integr Med
PD JUL 31
PY 2023
VL 21
IS 5
BP 496
EP 508
DI 10.1016/j.joim.2023.07.001 
PG 12
WC Rats; Animals; Rats, Sprague-Dawley; Neuroinflammatory Diseases; Electroacupuncture; Pain, Postoperative; Interferons
UT PubMed:37517892
PM 37517892
DA 2023-07-31
ER

PT J
AU Dean-Clower, E
   Doherty-Gilman, AM
   Keshaviah, A
   Baker, F
   Kaw, C
   Lu, W
   Manola, J
   Penson, RT
   Matulonis, UA
   Rosenthal, DS
AF Dean-Clower, Elizabeth
   Doherty-Gilman, Anne M
   Keshaviah, Aparna
   Baker, Frank
   Kaw, Chiewkwei
   Lu, Weidong
   Manola, Judith
   Penson, Richard T
   Matulonis, Ursula A
   Rosenthal, David S
TI Acupuncture as palliative therapy for physical symptoms and quality of life for 
SO Integrative cancer therapies
LA English
DT Journal Article
AB BACKGROUND: Acupuncture is underutilized as an adjunct cancer therapy. The main 
   study objectives were to determine the feasibility of administering acupuncture 
   as palliative therapy to patients with advanced ovarian or breast cancer and to 
   assess the effect on symptoms and quality of life (QOL). METHODS: This study was 
   a pilot, single-armed prospective clinical trial for patients with advanced 
   cancer to receive 12 acupuncture sessions over 8 weeks with follow-up at weeks 9 
   and 12. Ambulatory patients with advanced ovarian or breast cancer were enrolled 
   to receive treatments at an outpatient academic oncology center. Symptom severity 
   was measured before and after each acupuncture session.A composite QOL assessment 
   tool, consisting of validated instruments, was completed at 5 time points. 
   RESULTS: Forty patients enrolled in the study. Twenty-eight patients (70%; 95% 
   confidence interval [CI] = 53%-83%) completed 4 weeks of treatment, and 26 
   patients (65%; 95% CI = 48%-79%) completed 8 weeks. Eight patients (20%) withdrew 
   before receiving acupuncture, and 6 patients (15%) discontinued treatment early 
   because of disease progression or scheduling demands. Among all 32 assessed 
   patients, there was self-reported improvement immediately post-treatment in 
   anxiety,fatigue, pain, and depression and significant improvement over time for 
   patients with anxiety (P = .001) and depression(P = .02). Among patients 
   experiencing baseline symptoms, there was improvement in anxiety (P = .001), 
   fatigue (P = .0002),pain (P = .0002), and depression (P = .003). QOL measures of 
   pain severity and interference, physical and psychological distress, life 
   satisfaction, and mood states showed improved scores during treatment, with 
   sustained benefit at 12 weeks. CONCLUSIONS: This pilot study demonstrates that an 
   8-week outpatient acupuncture course is feasible for advanced cancer patients and 
   produces a measurable benefit that should be evaluated in controlled trials.
C1 Leonard P. Zakim Center for Integrative Therapies, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115, USA.
NR 0
TC 0
SN 1552-695
EI 
J9 Integr Cancer Ther
PD MAY 21
PY 2010
VL 9
IS 2
BP 158
EP 67
DI 10.1177/1534735409360666 
PG -91
WC Acupuncture Therapy; methods; Adult; Aged; Ambulatory Care; Feasibility Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasms; physiopathology; Palliative Care; methods; Pilot Projects; Prospective Studies; Quality of Life; Severity of Illness Index; Time Factors
UT PubMed:20483875
PM 20483875
DA 2010-05-21
ER

PT J
AU Lu, J
   Zhang, Z
AF Lu, Jing
   Zhang, Zhaohui
TI [Review and prospect of clinical application of ear-acupuncture treating 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Review
DE anxiety-depression; breast cancer; ear-acupuncture; joint pain; nausea and vomiting; review; sleep disorders
AB To analyze the application of ear-acupuncture for post-operative syndromes of 
   breast cancer so as to provide method and evidence for the syndromes. The related 
   clinical literature was retrieved from CNKI, WANFANG and VIP databases from the 
   database establishment time to August 30, 2017. We found ear-acupuncture are 
   mainly used in treating nausea and vomiting caused by radiation and chemotherapy 
   (shenmen (TF(4)), jiaogan (AH(6a)), wei (CO(4)), pi (CO(13)), etc), insomnia in 
   the rehabilitation period (xin (CO(15)), pizhixia (AT(4)), shenmen (TF(4)), etc), 
   depression and anxiety (pizhixia (AT(4)), shenmen (TF(4)), pi (CO(13)), wei 
   (CO(4)), xin (CO(15)), gan (CO(12)), etc), and joint pain (pain point), etc.
C1 Departmeng of Acupuncture and Moxibustion, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
   Departmeng of Acupuncture and Moxibustion, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JAN 24
PY 2019
VL 38
IS 11
BP 1249
EP 54
DI 10.13703/j.0255-2930.2018.11.031 
PG -1195
WC Acupuncture Points; Acupuncture, Ear; Breast Neoplasms; Humans; Postoperative Period; Syndrome
UT PubMed:30672210
PM 30672210
DA 2019-01-24
ER

PT J
AU Jiang, X
   Tian, Y
   Xu, L
   Zhang, Q
   Wan, Y
   Qi, X
   Li, B
   Guo, J
   Sun, W
   Luo, A
   Huang, J
   Gu, X
AF Jiang, Xin
   Tian, Yehong
   Xu, Lin
   Zhang, Qiaoli
   Wan, Yuxiang
   Qi, Xuewei
   Li, Bo
   Guo, Jing
   Sun, Weiliang
   Luo, Aiping
   Huang, Jinchang
   Gu, Xiaohong
TI Inhibition of Triple-Negative Breast Cancer Tumor Growth by Electroacupuncture 
SO International journal of medical sciences
LA English
DT Journal Article
DE Electroacupuncture; Encircled needling; Mechanisms; Triple-negative breast cancer; Tumor inhibition
AB Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast 
   cancer without effective targeted drugs. While breast cancer patients often use 
   acupuncture for the relief of cancer-induced pain or the side effects of chemo- 
   or radiation therapy, little information is known regarding the direct effects of 
   electroacupuncture on TNBC tumor and its potential mechanisms. Here, we created a 
   mice model of TNBC and electroacupuncture with encircled needling around the 
   tumors was given to the animals daily for 3 weeks at 15-20 Hz (3 min, each time). 
   For sham electroacupuncture control, the skin was punctured to a depth of 5 mm 
   and then the needle was quickly withdrawn without electrical stimulation or 
   manual needle manipulation. We found that electroacupuncture significantly 
   inhibited TNBC tumor growth and the inhibitory rate increased gradually overtime. 
   Mechanistic analysis showed that electroacupuncture inhibited tumor angiogenesis 
   by reducing the expression of vascular endothelial growth factor A (VEGF-A), its 
   receptor VEGF-R and neuropilin 1 (NRP-1). Electroacupuncture also led to a 
   significant decrease of matrix metalloproteinase-2 (MMP-2) expression and an 
   increase of tissue inhibitor of MMP (TIMP-2) expression. Additionally, the 
   expression of semaphorin 3A (Sema3A) and nerve growth factor receptor (NGFR) p75 
   in TNBC tissue was significantly upregulated in response to electroacupuncture. 
   Furthermore, tumor necrosis factor (TNF)-alpha level in the serum was 
   dramatically reduced after electroacupuncture. These results showed that 
   electroacupuncture could directly inhibit TNBC tumor growth through the 
   inhibition of proteins related to tumor angiogenesis and extracellular matrix, 
   the suppression of TNBC-induced inflammation and the upregulation of nerve growth 
   factor receptors.
C1 Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029, China.
   School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
   Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029, China.
   Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029, China.
   Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029, China.
   Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029, China.
   Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029, China.
   Department of Traditional Chinese Medicine, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
   Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China.
   Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China.
   State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciencesand Peking Union Medical College, Beijing 100021, China.
   Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029, China.
   School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
NR 0
TC 0
SN 1449-190
EI 
J9 Int J Med Sci
PD DEC 17
PY 2019
VL 16
IS 12
BP 1642
EP 1651
DI 10.7150/ijms.38521 
PG 9
WC Animals; Cell Line, Tumor; Cell Movement; genetics; Cell Proliferation; genetics; Disease Models, Animal; Electroacupuncture; Female; Gene Expression Regulation, Neoplastic; genetics; Humans; Matrix Metalloproteinase 2; genetics; Mice; Neovascularization, Pathologic; genetics; Semaphorin-3A; genetics; Tissue Inhibitor of Metalloproteinase-2; genetics; Triple Negative Breast Neoplasms; therapy; Tumor Necrosis Factor-alpha; genetics; Vascular Endothelial Growth Factor A; genetics; Xenograft Model Antitumor Assays
UT PubMed:31839752
PM 31839752
DA 2019-12-17
ER

PT J
AU Zeng, YJ
   Lin, YH
   Wang, YC
   Chang, JH
   Wu, JH
   Hsu, SF
   Tsai, SY
   Lin, CH
   Wen, YR
AF Zeng, Yen-Jing
   Lin, Yu-Hsiang
   Wang, You-Cheng
   Chang, Ju-Hsin
   Wu, Jih-Huah
   Hsu, Sheng-Feng
   Tsai, Shih-Ying
   Lin, Ching-Huang
   Wen, Yeong-Ray
TI Laser acupuncture-induced analgesic effect and molecular alterations in an 
SO Lasers in medical science
LA English
DT Journal Article
DE Laser acupuncture; MAPK; Postoperative pain; TNF; iNOS
AB Low-level laser acupuncture (LLLA) produces photobiomodulation through 
   acupuncture point and is an alternative to low-level laser therapy. Although the 
   analgesic effect of LLLA on chronic pain has been proven, its effect on acute 
   postincisional pain has yet to be investigated. A plantar incision (PI) model was 
   used to mimic human postsurgical pain. Male adult rats received GaAlAs laser 
   irradiation at the right ST36 acupoint immediately after operation and on the 
   following 4 days. Three laser treatment groups (two red laser groups with a 30- 
   or 15-min treatment duration and one 30-min near-infrared laser group) were 
   compared with sham LLLA and naive groups and an electroacupuncture (EA) group 
   (separate study). Behavioral withdrawal thresholds of both hind paws were 
   measured before and after incision. Expression of mitogen-activated protein 
   kinases (p-ERK and p-p38), inducible nitric oxide synthase (iNOS), and tumor 
   necrosis factor (TNF) in the spinal cord was analyzed. All three LLLA treatments 
   attenuated post-PI tactile allodynia in the ipsilateral paw, but only the 30-min 
   red laser treatment affected the contralateral paw and had similar efficacy to 
   that of EA. All laser treatments barely reduced heat hyperalgesia in both hind 
   paws. At 3 days after PI, the 30-min red laser group showed reversed increases of 
   PI-induced p-ERK, p-p38, and iNOS but not TNF expression in the spinal cord. 
   Repetitive LLLA treatments ameliorated PI-induced mechanical pain. The inhibition 
   of multiple sensitization signals highlights the unique clinical role of LLLA. 
   Thus, LLLA is an alternative to EA as an adjuvant for postoperative pain control.
C1 Graduate Institute of Clinical Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
   Microelectronic and Optoelectronic Engineering Department of Electronic Engineering, National Yunlin University of Science and Technology, Yunlin,Taiwan.
   Department of Electronic Engineering, National Yunlin University of Science and Technology, Yunlin, Taiwan.
   Graduate Institute of Clinical Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
   Department of Anesthesiology, China Medical University Hospital, No. 2, Yuh-Der 
   Department of Biomedical Engineering, Ming Chuan University, Taipei City, Taiwan.
   Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
   Department of Acupuncture, China Medical University Hospital Taipei Branch, 
   Acupuncture Research Center, China Medical University, Taichung, Taiwan.
   Department of Anesthesiology, China Medical University Hospital, No. 2, Yuh-Der Rd, North District, 40447, Taichung, Taiwan.
   Microelectronic and Optoelectronic Engineering Department of Electronic Engineering, National Yunlin University of Science and Technology, Yunlin,Taiwan.
   Department of Electronic Engineering, National Yunlin University of Science and 
   Department of Anesthesiology, China Medical University Hospital, No. 2, Yuh-Der Rd, North District, 40447, Taichung, Taiwan. yr.wen@yahoo.com.tw.
   Graduate Institute of Acupuncture Science, College of Chinese Medicine, China 
   Acupuncture Research Center, China Medical University, Taichung, Taiwan. yr.wen@yahoo.com.tw.
   Department of Anesthesiology, School of Medicine, China Medical University, 
   Center for Pain Research and Management, Department of Anesthesiology, School of Medicine, China Medical University, Taichung, Taiwan. yr.wen@yahoo.com.tw.
NR 0
TC 0
SN 1435-604
EI 0268-892
J9 Lasers Med Sci
PD NOV 6
PY 2017
VL 33
IS 2
BP 295
EP 304
DI 10.1007/s10103-017-2367-7 
PG 9
WC Acupuncture Points; Analgesics; pharmacology; Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electroacupuncture; Extracellular Signal-Regulated MAP Kinases; metabolism; Humans; Hyperalgesia; therapy; Laser Therapy; Male; Nitric Oxide Synthase Type II; metabolism; Pain; enzymology; Pain Management; Rats, Sprague-Dawley; p38 Mitogen-Activated Protein Kinases; metabolism
UT PubMed:29103083
PM 29103083
DA 2017-11-06
ER

PT J
AU Enblom, A
   Johnsson, A
AF Enblom, Anna
   Johnsson, Anna
TI Type and frequency of side effects during PC6 acupuncture: observations from 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE Acupuncture; Adverse Events; Clinical Trials; Complementary Medicine; Physiotherapy
AB BACKGROUND: Many therapists practise PC6 acupuncture for emesis (nausea and 
   vomiting) during pregnancy, different cancer therapies, palliative care, after 
   surgery, or to induce relaxing effects in general. Knowledge of side effects is 
   central to shared decision-making. AIM: To describe the type and frequency of 
   side effects and the level of needle-induced pain during PC6 acupuncture. 
   METHODS: We included 1298 PC6 acupuncture treatments, delivered to 221 
   participants (77% women, mean age 52.5, range 18-91 years). The subjects had 
   received genuine PC6 acupuncture, in one of two previous randomised controlled 
   trials, aimed at inducing antiemetic (n=100, with 100 providing data on side 
   effects and 94 on needle-induced pain, respectively) or relaxing (n=121, with 120 
   providing data) effects. Side effects during and after the acupuncture treatments 
   were registered in structured treatment protocols and study diaries. RESULTS: No 
   serious complications occurred. Side effects during the acupuncture sessions 
   included minor bleeding in 5.0%, tiredness in 4.9%, numbness in 4.5% and 
   dizziness in 1.4% of the 1298 treatments. After treatment, the mean proportions 
   of participants reporting side effects each week were: tiredness 25.8%; feeling 
   cold 17.8%; dizziness 9.7%; sweating 9.3%; haematoma 8.8%; and soreness at the 
   needling sites 4.3%. Participants perceived the needling to be not painful (47.4% 
   of participants), or mildly (39.1%), moderately (11.6%) or very painful (1.4%). 
   CONCLUSIONS: Few side effects occurred and those that did were mild. Nearly 90% 
   found PC6 acupuncture to be not painful or only mildly painful. Healthcare 
   professionals may consider the observed levels of side effects when informing 
   patients about side effects of PC6 acupuncture.
C1 Region of Östergötland and Department of Medical and Health Sciences, Division of Physiotherapy, Linköping University, Sweden.
   Department of Oncology, Skåne University Hospital, and Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD DEC 10
PY 2017
VL 35
IS 6
BP 421
EP 429
DI 10.1136/acupmed-2016-011270 
PG 8
WC Acupuncture Points; Acupuncture Therapy; adverse effects; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Pain; etiology; Patient Satisfaction; Postoperative Nausea and Vomiting; prevention & control; Symptom Assessment; Young Adult
UT PubMed:29222203
PM 29222203
DA 2017-12-10
ER

PT J
AU Zhong, X
   Zhang, Z
   Li, J
   Liu, D
   Ma, C
   Wang, G
AF Zhong, Xuelai
   Zhang, Zhaodi
   Li, Jiaying
   Liu, Dandan
   Ma, Chao
   Wang, Guonian
TI Effects of Electroacupuncture on Gastrointestinal Motility Function, Pain, and 
SO Disease markers
LA English
DT Journal Article
AB BACKGROUND: Complications after colon surgery are a major obstacle to 
   postoperative recovery. The purpose of this study was to investigate the effect 
   of electroacupuncture (EA) at Zusanli (ST36) on gastrointestinal motility in rats 
   after colonic anastomosis and the mechanism of transient receptor potential 
   vanillin 1 (TRPV1) channel in regulating gastrointestinal motility, pain, and 
   inflammation. METHODS: The rats were randomly divided into six groups, including 
   the control, model, EA, sham-EA, capsaicin, and capsaicin+EA groups, with 
   preoperative capsaicin pretreatment and EA treatment at ST36 acupoint after 
   surgery. Rats were treated using EA at ST36 or sham acupoints after surgery for 5 
   days. Capsaicin was intraperitoneally injected into rats 3 hours before surgery. 
   Gastrointestinal motility was assessed by measuring the gastric residue, small 
   intestinal propulsion in vivo, contractile tension, and frequency of isolated 
   muscle strips in vitro. The mechanical withdrawal threshold (MWT) of abdominal 
   incision skin and spontaneous nociceptive scores were observed and recorded in 
   rats after colon anastomosis. The expressions of TRPV1, substance P (SP), 
   neurokinin 1 (NK1) receptor, nuclear factor kappa-B (NF-κB), interleukin- (IL-) 
   6, L-1β, and tumor necrosis factor- (TNF-) α were determined. RESULTS: Compared 
   with the model group, electroacupuncture at ST36 point could significantly reduce 
   the residual rate of stomach in rats after operation and increase the propulsive 
   force of the small intestine and the contraction tension of the isolated smooth 
   muscle. Electroacupuncture also increased postoperative day 3 MWT values and 
   decreased postoperative spontaneous nociception scores. In addition, 
   electroacupuncture treatment downregulated the expressions of IL-6, IL-1β, TNF-α, 
   TRPV1, NF-κB, SP, and NK1 receptors in the colon tissue of rats after colonic 
   anastomosis. CONCLUSIONS: Our study showed that electroacupuncture at ST36 
   acupoint could improve gastrointestinal motility in rats after colonic 
   anastomosis and relieve intestinal inflammation and pain. The mechanism may be to 
   inhibit the activation of NF-κB and SP/NK1 receptor signaling pathways by 
   inhibiting TRPV1.
C1 Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin 150081, China.
   Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin 150081, China.
   Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin 150081, China.
   Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin 150081, China.
   Department of Anesthesiology, The Fourth Hospital of Harbin Medical University, Harbin 150081, China.
   Department of Anesthesiology, The Fourth Hospital of Harbin Medical University
   Pain Research Institute of Heilongjiang Academy of Medical Science, 150 HapingRd, Nangang District, Harbin 150081, China.
NR 0
TC 0
SN 1875-863
EI 0278-024
J9 Dis Markers
PD JUL 19
PY 2022
VL 2022
IS 
BP 5113473
EP 5113473
DI 10.1155/2022/5113473 
PG 0
WC Animals; Capsaicin; pharmacology; Electroacupuncture; Gastrointestinal Motility; Inflammation; therapy; NF-kappa B; metabolism; Pain; Rats; Tumor Necrosis Factor-alpha; metabolism
UT PubMed:35845135
PM 35845135
DA 2022-07-19
ER

PT J
AU Zhu, HD
   Gong, Z
   Hu, BW
   Wei, QL
   Kong, J
   Peng, CB
AF Zhu, Hua-Dong
   Gong, Zhen
   Hu, Bing-Wei
   Wei, Qiao-Ling
   Kong, Jun
   Peng, Cong-Bin
TI The Efficacy and Safety of Transcutaneous Acupoint Interferential Current 
SO Integrative cancer therapies
LA English
DT Journal Article
DE cancer pain; lactulose; opioid-induced constipation; quality of life; transcutaneous acupoint interferential current therapy
AB INTRODUCTION: Opioid-induced constipation (OIC) is a principal complication 
   secondary to analgesic therapy for cancer pain patients who suffer moderate to 
   severe pain. In this study, we observe the efficacy and safety of transcutaneous 
   acupoint interferential current (IFC) stimulation in those patients with OIC. 
   METHODS: A total of 198 patients were randomly allocated to the IFC group and 
   control group in a 1:1 ratio. Finally, 98 patients in the IFC group received 14 
   sessions administered over 2 weeks, whereas 100 patients in the control group 
   took lactulose orally during the same period. Observation items were documented 
   at management stage and at follow-up stage according to Cleveland Constipation 
   Scales (CCS), pain Numeric Rating Scales (NRS) and Patient Assessment of 
   Constipation Quality of Life (PAC-QoL). RESULTS: The total curative effects of 
   the IFC group and the control group were indistinguishable (76.5% vs 70.0%, P = 
   .299). Regarding CCS and PAC-QoL scores, no significant difference was observed 
   between the 2 groups during the management time and at the follow-up stage of 
   week 3 ( P > .05, respectively), but groups were distinguished at the follow-up 
   stage of week 4 ( P < .001 and P = .031, respectively). The pain NRS decreased 
   significantly at management stage week 2 and follow-up stage week 3 and week 4 ( 
   P = .013, P = .041, P = .011, respectively). CONCLUSIONS: Transcutaneous acupoint 
   IFC therapy over acupoints of Tianshu (ST25) and Zhongwan (RN12) may improve 
   constipation and quality of life in cancer patients receiving opiates; further 
   studies are worthwhile.
C1 1 Tongde Hospital of Zhejiang Province, Hangzhou, China.
   1 Tongde Hospital of Zhejiang Province, Hangzhou, China.
   1 Tongde Hospital of Zhejiang Province, Hangzhou, China.
   1 Tongde Hospital of Zhejiang Province, Hangzhou, China.
   1 Tongde Hospital of Zhejiang Province, Hangzhou, China.
   1 Tongde Hospital of Zhejiang Province, Hangzhou, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD OCT 28
PY 2017
VL 17
IS 2
BP 437
EP 443
DI 10.1177/1534735417734910 
PG 6
WC Acupuncture Points; Analgesics, Opioid; adverse effects; Cancer Pain; therapy; Constipation; chemically induced; Female; Humans; Male; Middle Aged; Pain Management; methods; Prospective Studies; Quality of Life; Treatment Outcome
UT PubMed:29076387
PM 29076387
DA 2017-10-28
ER

PT J
AU Hsieh, YL
   Chou, LW
   Hong, SF
   Chang, FC
   Tseng, SW
   Huang, CC
   Yang, CH
   Yang, CC
   Chiu, WF
AF Hsieh, Yueh-Ling
   Chou, Li-Wei
   Hong, Shao-Fu
   Chang, Fei-Chi
   Tseng, Szu-Wen
   Huang, Chi-Chou
   Yang, Ching-Hsiang
   Yang, Chen-Chia
   Chiu, Wei-Feng
TI Laser acupuncture attenuates oxaliplatin-induced peripheral neuropathy in 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE ONCOLOGY
AB BACKGROUND: Oxaliplatin is a platinum compound that is widely used in the 
   treatment of some solid tumours. Oxaliplatin-induced peripheral neuropathy (OIPN) 
   in the upper and lower extremities is the major adverse side effect and 
   represents the main dose-limiting factor of this drug. The aim of this single-arm 
   study was to evaluate the feasibility and effects of laser acupuncture (LA) in 
   the treatment of OIPN in patients with advanced gastrointestinal cancers. 
   METHODS: 17 gastrointestinal cancer survivors (14 colorectal and 3 gastric 
   cancers), who had been treated with oxaliplatin-based chemotherapies, were 
   recruited. Low-level laser stimulation (50 mW) bilaterally at PC6, PC7, PC8, P9, 
   LU11, SP6, KI3, BL60, KI1, and KI2 was administered for 20 min/point for 12 
   sessions over 4 weeks. The pain quality assessment scale (PQAS), 
   chemotherapy-induced neurotoxicity questionnaire (CINQ), oxaliplatin-specific 
   neurotoxicity scale (OSNS), quantitative touch-detection threshold (using von 
   Frey filaments), and cold-triggered pain withdrawal latency (using the cold-water 
   immersion test) were measured before and after completion of the 12 treatment 
   sessions. RESULTS: PQAS, CINQ, and OSNS scores, as well as touch-detection 
   threshold and cold-trigger pain withdrawal latency all improved significantly 
   after LA in the cancer patients with OIPN (p<0.05). LA significantly relieved 
   both oxaliplatin-induced cold and mechanical allodynia and also decreased the 
   incidence and severity of neurotoxicity symptoms in the patients' upper and lower 
   extremities and impact on their daily activities (all p<0.05). CONCLUSIONS: 
   Following treatment with LA, neurotoxicity symptoms were significantly improved 
   in cancer patients with OIPN. Further randomised controlled trials are needed to 
   evaluate the role of LA as a therapeutic option in the management of OIPN.
C1 Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan.
   Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, Taiwan Department of Physical Medicine andRehabilitation, China Medical University Hospital, Taichung, Taiwan.
   Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan Department of Physical Medicine andRehabilitation, Chung Shan Medical University Hospital Chung Shing Branch,Taichung, Taiwan.
   Nursing Department, Chung Shan Medical University Hospital, Taichung, Taiwan.
   Department of Internal Medicine, Division of Medical Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan.
   School of Medicine, Chung Shan Medical University, Taichung, Taiwan Department of Surgery, Division of Colon and Rectum, Chung Shan Medical University Hospital,Taichung, Taiwan.
   Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan.
   Department of Physical Medicine and Rehabilitation, Cheng Ching General Hospital, Taichung, Taiwan.
   Department of Physical Medicine and Rehabilitation, Cheng Ching General Hospital, Taichung, Taiwan.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD SEP 11
PY 2016
VL 34
IS 5
BP 398
EP 405
DI 10.1136/acupmed-2016-011112 
PG 7
WC Acupuncture Therapy; methods; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; adverse effects; Female; Gastrointestinal Neoplasms; drug therapy; Humans; Laser Therapy; methods; Male; Middle Aged; Organoplatinum Compounds; adverse effects; Oxaliplatin; Pain; etiology; Peripheral Nervous System Diseases; chemically induced; Pilot Projects; Prospective Studies; Treatment Outcome
UT PubMed:27613370
PM 27613370
DA 2016-09-11
ER

PT J
AU Serçe, S
   Ovayolu, Ö
   Pirbudak, L
   Ovayolu, N
AF Serçe, Sibel
   Ovayolu, Özlem
   Pirbudak, Lütfiye
   Ovayolu, Nimet
TI Response to "Statistical Concerns About Acupressure on Pain in Cancer Patients 
SO Integrative cancer therapies
LA English
DT Letter
C1 1 Gaziantep University Hospital, Gaziantep, Turkey.
   2 Gaziantep University, Gaziantep, Turkey.
   2 Gaziantep University, Gaziantep, Turkey.
   2 Gaziantep University, Gaziantep, Turkey.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD MAR 19
PY 2019
VL 18
IS 
BP 1534735419834355
EP 1534735419834355
DI 10.1177/1534735419834355 
PG 1
WC Acupressure; Bone Neoplasms; Cancer Pain; Humans; Pain
UT PubMed:30879342
PM 30879342
DA 2019-03-19
ER

PT J
AU Tas, D
   Uncu, D
   Sendur, MA
   Koca, N
   Zengin, N
AF Tas, Demet
   Uncu, Dogan
   Sendur, Mehmet Ali
   Koca, Nuran
   Zengin, Nurullah
TI Acupuncture as a complementary treatment for cancer patients receiving 
SO Asian Pacific journal of cancer prevention : APJCP
LA English
DT Journal Article
AB BACKGROUND: Medical treatment for eliminating the side effects of cancer therapy 
   may not always be efficacious. Acupuncture is one of the most widely accepted 
   alternative and complementary therapies in use today. In this study, we 
   investigated the efficacy of acupuncture in patients experiencing cancer 
   treatment side effects, including nausea, vomiting, pain, poor sleep quality and 
   anxiety. MATERIALS AND METHODS: A total of 45 inpatients who underwent 
   chemotherapy between February and April 2013 in the Oncology Department of Numune 
   Hospital were included in our study. Acupuncture was administered to the patients 
   one day prior to chemotherapy, on the day of chemotherapy and one day after 
   chemotherapy. The patients were evaluated on nausea, vomiting, pain, sleep 
   quality and anxiety before the chemotherapy and on the 4th day of chemotherapy. 
   RESULTS: Of the 45 patients included in the study, 18 (40%) were female and 27 
   (60%) were male. A total of 25 (55.6%) had an elementary school education; 32 
   patients (71%) had stage 4 cancer and were treated with palliative chemotherapy 
   (the patient characteristics are shown in Table 1). Statistically significant 
   decreases (p<0.001) in pain, nausea, vomiting, insomnia and anxiety scores were 
   observed after the acupuncture treatment compared to baseline. There were no 
   differences in the age, gender, education level, stage or metastasis levels 
   between the patient groups whose symptoms improved or were unchanged. 
   CONCLUSIONS: Our study showed that acupuncture has positive effects in cancer 
   treatment patients who experience nausea, vomiting, pain, poor sleep quality and 
   anxiety as side effects of chemotherapy. Chemotherapy-related side effects in 
   cancer patients could be decreased by the concurrent use of acupuncture.
C1 Traditional, Complementary and Alternative Medicine Department, Ministry of Health, Ankara, Turkey E-mail : demettas19691@hotmail.com.
NR 0
TC 0
SN 2476-762
EI 
J9 Asian Pac J Cancer Prev
PD MAY 13
PY 2014
VL 15
IS 7
BP 3139
EP 44
DI 10.7314/apjcp.2014.15.7.3139 
PG -3095
WC Acupuncture Therapy; Adult; Aged; Antineoplastic Agents; adverse effects; Anxiety; therapy; Female; Humans; Male; Middle Aged; Nausea; therapy; Neoplasms; drug therapy; Pain Management; methods; Sleep Initiation and Maintenance Disorders; therapy; Turkey; Vomiting; therapy; Young Adult
UT PubMed:24815460
PM 24815460
DA 2014-05-13
ER

PT J
AU Zhao, ZT
   Zhao, YK
   Chen, JL
   Zhu, TT
   Yan, XK
   Zhang, YF
AF Zhao, Zhong-Ting
   Zhao, Yi-Kun
   Chen, Jia-Lian
   Zhu, Tian-Tian
   Yan, Xing-Ke
   Zhang, Yan-Feng
TI [Effect of different suspension moxibustion methods on syndrome characteristics 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE heat bi syndrome; inflammatory response; moxibustion can be used for heat syndrome; rheumatoid arthritis; suspension moxibustion
AB OBJECTIVE: To observe the effects of different suspension moxibustion methods on 
   the syndrome characteristics and inflammatory factors of rats with rheumatoid 
   arthritis (RA) of heat bi syndrome and to prove the concept of "moxibustion can 
   be used for heat syndrome". METHODS: Among seventy Wistar rats, 12 rats were 
   randomly selected as a normal group, and the remaining rats were induced by 
   collagen combined with wind, dampness, and heat environmental stimulation to 
   establish the RA model of heat bi syndrome. Forty-eight rats with successful 
   model establishment were further randomly divided into a model group and three 
   moxibustion groups (mild moxibustion group, rotating moxibustion group and 
   sparrow-pecking moxibustion group), with 12 rats in each group. The acupoints 
   "Quchi" (LI 11), "Dazhui" (GV 14) and ashi point were used in all moxibustion 
   groups, with mild moxibustion, rotating moxibustion, and sparrow-pecking 
   moxibustion intervention given respectively, each acupoint was treated with 
   moxibustion for 10 min a day, and 6 days were considered one course of treatment, 
   with a total of three courses. After the intervention, the arthritis index (AI), 
   the Evans blue (EB) extravasated volume in the soft tissue of the right hind paw, 
   and the levels of tumor necrosis factor (TNF)-α and interleukin (IL)-10 in the 
   serum were measured by ELISA in each group. The volume of the bilateral hind paw 
   was measured; the infrared thermal imaging was collected to analyze the 
   temperature of the plantar area of the bilateral foot pads, and the reaction time 
   of plantar heat pain was calculated before and after modeling, as well as after 
   the 1st, 2nd and 3rd courses of interrention. The ankle dorsiflexion angle of the 
   right hind foot was also measured before and after modeling, as well as after the 
   intervention. RESULTS: After modeling, compared with the normal group, the rats 
   in the model group had more high-temperature areas in the bilateral hind limbs, 
   abnormal AI score, abnormal bilateral hind paw volume, abnormal temperature of 
   the plantar area of the bilateral foot pads, abnormal foot pain response time, 
   abnormal right hind ankle dorsiflexion angle, abnormal right hind paw soft tissue 
   EB extravasation, and abnormal serum TNF-α and IL-10 levels (P<0.01, P<0.05). 
   After the intervention, compared with the model group, the rats in each 
   moxibustion group had decreased or disappeared high-temperature areas in the 
   bilateral hind limbs, EB extravasated volume in the soft tissue of the right hind 
   paw was reduced (P<0.05), and the right ankle dorsiflexion angle was increased 
   (P<0.05), serum level of TNF-α was reduced, and level of IL-10 increased 
   (P<0.05); the AI scores in the mild moxibustion group and the sparrow-pecking 
   moxibustion group was decreased (P<0.01, P<0.05). After the 1st, 2nd and 3rd 
   courses of intervention, compared with the model group, the bilateral hind paw 
   volume of rats in each moxibustion group was decreased (P<0.05, P<0.01), and 
   plantar heat pain reaction time was increased (P<0.05). After the 2nd course and 
   the 3rd course of intervention, the temperature of the right hind paw pad area 
   was decreased in each moribustion group (P<0.05); after the 3rd courses of 
   intervention, the temperature of the left hind paw pad area was decreased in the 
   mild moxibustion group (P<0.05). CONCLUSION: Suspension moxibustion could adjust 
   the serum levels of TNF-α and IL-10 to improve the syndrome characteristics of RA 
   rats of heat bi syndrome, such as joint redness, swelling, heat, pain and 
   activity restriction. The effect of mild moxibustion is the most prominent. The 
   findings could provide scientific basis for "moxibustion can be used for heat 
   syndrome".
C1 College of Acupuncture-Moxibustion and Tuina, Gansu University of CM, Lanzhou 730101, China.
   College of Acupuncture-Moxibustion and Tuina, Gansu University of CM, Lanzhou 730101, China.
   College of Acupuncture-Moxibustion and Tuina, Gansu University of CM, Lanzhou 730101, China.
   College of Acupuncture-Moxibustion and Tuina, Gansu University of CM, Lanzhou 730101, China.
   College of Acupuncture-Moxibustion and Tuina, Gansu University of CM, Lanzhou 730101, China.
   College of Acupuncture-Moxibustion and Tuina, Gansu University of CM, Lanzhou 730101, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD SEP 12
PY 2023
VL 43
IS 9
BP 1062
EP 9
DI 10.13703/j.0255-2930.20220807-0001 
PG -1053
WC Animals; Rats; Arthritis, Rheumatoid; therapy; Evans Blue; Hot Temperature; Interleukin-10; genetics; Moxibustion; Rats, Wistar; Tumor Necrosis Factor-alpha; genetics
UT PubMed:37697883
PM 37697883
DA 2023-09-12
ER

PT J
AU Molassiotis, A
   Suen, LKP
   Cheng, HL
   Mok, TSK
   Lee, SCY
   Wang, CH
   Lee, P
   Leung, H
   Chan, V
   Lau, TKH
   Yeo, W
AF Molassiotis, Alexander
   Suen, Lorna K P
   Cheng, Hui Lin
   Mok, T S K
   Lee, Sara C Y
   Wang, C H
   Lee, Paul
   Leung, Howan
   Chan, V
   Lau, T K H
   Yeo, Winnie
TI A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; cancer; chemotherapy-induced peripheral neuropathy; neurotoxicity; pain; quality of life
AB PURPOSE: Chemotherapy-induced peripheral neuropathy is a complex side effect with 
   few available treatment options. The aim of the study was to test the 
   effectiveness of an 8-week course of acupuncture in the management of 
   chemotherapy-induced peripheral neuropathy in cancer patients who were receiving 
   or had received neurotoxic chemotherapy. METHODS: Randomized assessor-blinded 
   controlled trial with 2 arms; one arm received acupuncture twice weekly for 8 
   weeks, while the other arm was a wait-list control group receiving only standard 
   care. Primary outcome was pain intensity and interference over the past week 
   using the Brief Pain Inventory at the end of the intervention. Secondary outcomes 
   included clinical assessment (CTCAE [Common Toxicity Criteria for Adverse Events] 
   grading and Total Neuropathy Score-Clinical Version) and nerve conduction 
   studies; and patient-reported outcome measures (Functional Assessment of Cancer 
   Therapy-Gynecologic Oncology Group-Neurotoxicity Quality of Life scale and 
   Symptom Distress Scale) assessed at baseline, end of treatment (8 weeks), week 
   14, and week 20 from the beginning of treatment. RESULTS: Eighty-seven patients 
   were randomized to the experimental arm (n = 44) and to the standard care 
   wait-list control arm (n = 43). Significant changes at 8 weeks were detected in 
   relation to primary outcome (pain), the clinical neurological assessment, quality 
   of life domains, and symptom distress (all P < .05). Improvements in pain 
   interference, neurotoxicity-related symptoms, and functional aspects of quality 
   of life were sustained in the 14-week assessment ( P < .05), as were physical and 
   functional well-being at the 20-week assessment ( P < .05). CONCLUSIONS: 
   Acupuncture is an effective intervention for treating chemotherapy-induced 
   peripheral neuropathy and improving patients' quality of life and experience with 
   neurotoxicity-related symptoms with longer term effects evident.
C1 1 The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR.
   1 The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR.
   1 The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR.
   2 Prince of Wales Hospital, Sha Tin, Hong Kong SAR.
   1 The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR.
   2 Prince of Wales Hospital, Sha Tin, Hong Kong SAR.
   1 The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR.
   2 Prince of Wales Hospital, Sha Tin, Hong Kong SAR.
   2 Prince of Wales Hospital, Sha Tin, Hong Kong SAR.
   2 Prince of Wales Hospital, Sha Tin, Hong Kong SAR.
   2 Prince of Wales Hospital, Sha Tin, Hong Kong SAR.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD MAR 25
PY 2019
VL 18
IS 
BP 1534735419836501
EP 1534735419836501
DI 10.1177/1534735419836501 
PG 1
WC Acupuncture; methods; Acupuncture Therapy; methods; Antineoplastic Agents; adverse effects; Female; Humans; Male; Middle Aged; Neoplasms; drug therapy; Pain; chemically induced; Peripheral Nervous System Diseases; chemically induced; Quality of Life; Surveys and Questionnaires
UT PubMed:30905173
PM 30905173
DA 2019-03-25
ER

PT J
AU Yang, P
   Wang, Y
   Xiao, Y
   Ma, Q
   Ma, R
   Mi, J
   Hui, J
AF Yang, Pu
   Wang, Yuanchun
   Xiao, Yingchun
   Ma, Qiaolin
   Ma, Runhong
   Mi, Jing
   Hui, Jianrong
TI Acupuncture for opioid-induced constipation: Protocol for a systematic review and 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Opioid-induced constipation (OIC) is one of the most common 
   complications of analgesic therapy for cancer pain patients who suffer moderate 
   to severe pain. Acupuncture as an effective treatment in constipation has been 
   widely applied. But its efficacy has not been assessed systematically. Thus, the 
   purpose of this study is to provide a protocol to explore the efficacy and safety 
   of acupuncture for OIC. METHODS: Randomized Controlled Trials (RCTs) of 
   acupuncture treatment for OIC in 4 Chinese electronic databases (China National 
   Knowledge Infrastructure, Chinese Biological and Medical Database, China 
   Scientific Journal Database, Wan-Fang Data) and 3 English electronic databases 
   (PubMed, Embase, Cochrane Library) will be searched from their inception to 
   September 31, 2020. RevMan 5.3 software and Stata 14.0 software will be used for 
   meta-analysis, EndNote X9.2 and Cochrane Risk of Bias Tool will be used for 
   literature screening and quality assessment. RESULTS: This study will present an 
   assessment of the efficacy and safety of acupuncture treatment for OIC patients 
   through summarize high-quality clinical evidence. CONCLUSION: The conclusion of 
   our systematic review and meta-analysis may provide evidence of whether 
   acupuncture treatment is beneficial to patients with OIC.INPLASY registration 
   number: INPLASY2020100026.
C1 School of Acupuncture-Moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xian.
   The Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China.
   School of Acupuncture-Moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xian.
   School of Acupuncture-Moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xian.
   School of Acupuncture-Moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xian.
   School of Acupuncture-Moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xian.
   School of Acupuncture-Moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xian.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD DEC 9
PY 2020
VL 99
IS 49
BP e23352
EP e23352
DI 10.1097/MD.0000000000023352 
PG 1
WC Acupuncture Therapy; adverse effects; Humans; Opioid-Induced Constipation; therapy; Quality of Life; Randomized Controlled Trials as Topic; Research Design; Meta-Analysis as Topic; Systematic Reviews as Topic
UT PubMed:33285714
PM 33285714
DA 2020-12-09
ER

PT J
AU Liou, KT
   Mao, JJ
AF Liou, Kevin T
   Mao, Jun J
TI In reply to "could acupuncture be a treatment option for cancer patients with 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Letter
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA. liouk@mskcc.org.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD OCT 29
PY 2020
VL 29
IS 1
BP 5
EP 5
DI 10.1007/s00520-020-05844-9 
PG 0
WC Acupuncture Therapy; Cancer Pain; drug therapy; Humans; Neoplasms; complications; Pain Management
UT PubMed:33111181
PM 33111181
DA 2020-10-29
ER

PT J
AU Xue, Y
   Zhu, Q
   Zhang, J
   Wang, X
AF Xue, Yahong
   Zhu, Qinbing
   Zhang, Jing
   Wang, Xiaofeng
TI Electroacupuncture alleviates capsaicin-induced rectal visceral pain in rats via 
SO Purinergic signalling
LA English
DT Journal Article
DE Disease; Electroacupuncture; P2X4 receptor; P38 mitogen-activated protein kinase; Rectal visceral pain; Transient receptor potential vanilloid-1
AB Electroacupuncture (EA), as a combination of traditional acupuncture and modern 
   electrotherapy, and has analgesic effects on various acute and chronic pain. It 
   has been proved to ameliorate chronic visceral pain, but its specific role in 
   rectal visceral pain remains underexplored. A capsaicin (CAP)-induced visceral 
   pain rat model was established, and behavioral pain responses were observed and 
   recorded. Measurement of mechanical pain threshold was performed using electronic 
   Von Frey system. Rectal tissues, and the activity of microglia cells were 
   detected by Hematoxylin/eosin staining and immunofluorescence, respectively. 
   Contents of interleukin (IL)-6, IL-1β and tumor necrosis factor-α (TNF-α) were 
   determined by enzyme-linked immunosorbent assay. Western blot was performed to 
   determine the expressions of P2X4 receptor (P2X4R), p38 mitogen-activated protein 
   kinase (p38), phosphorylated p38 (p-p38), transient receptor potential 
   vanilloid-1 (TRPV1) and ionized calcium binding adapter molecule 1 (Iba-1). 
   Transfection efficiency of TRPV1 overexpression plasmids was examined by 
   quantitative real-time polymerase chain reaction. EA abrogated CAP-induced 
   upregulation of behavioral pain responses and mechanical threshold, damage on 
   rectal tissue, activation of microglia, stimulation of inflammatory response and 
   promotion of P2X4R-p38-TRPV1 pathway expressions in rats, while P2X4R activation 
   reversed the effect of EA. P2X4R antagonist weakened CAP-induced upregulation of 
   P2X4R-p38-TRPV1 pathway expressions, microglia activation as well as increase of 
   IL-1β in HMO6 cells, which was reversed by TRPV1 overexpression. Collectively, EA 
   improves CAP-induced rectal visceral pain via inhibiting TRPV1 expression by 
   blocking the P2X4R-activated p38 pathway in microglia. However, the specificity 
   role of P2X4R needs to be confirmed by more experiment.
C1 Department of Anorectal, Nanjing Hospital of Chinese Medicine, Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, Jiangsu Province, China.xueyahong_1983@126.com.
   Graduate School of Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China.
   Graduate School of Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China.
   Department of Anorectal, Nanjing Hospital of Chinese Medicine, Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, Jiangsu Province, China.
NR 0
TC 0
SN 1573-954
EI 1573-953
J9 Purinergic Signal
PD JUN 25
PY 2025
VL 21
IS 4
BP 565
EP 576
DI 10.1007/s11302-025-10100-y 
PG 11
WC Animals; Electroacupuncture; methods; TRPV Cation Channels; metabolism; Visceral Pain; chemically induced; Receptors, Purinergic P2X4; metabolism; Male; Rats; Rats, Sprague-Dawley; Capsaicin; toxicity; p38 Mitogen-Activated Protein Kinases; metabolism; Rectum; metabolism; MAP Kinase Signaling System; physiology
UT PubMed:40560521
PM 40560521
DA 2025-06-25
ER

PT J
AU Kwon, KK
   Lacey, J
   Kerin-Ayres, K
   Heller, G
   Grant, S
AF Kwon, Ki Kyung
   Lacey, Judith
   Kerin-Ayres, Kim
   Heller, Gillian
   Grant, Suzanne
TI Acupuncture for the treatment of the pain-fatigue-sleep 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture; Cancer; Integrative oncology; Model validity; Symptom clusters
AB PURPOSE: Breast cancer survivors following disease-modifying treatment frequently 
   experience multiple-concurrent symptoms (Jansana et al. in Int J Cancer 
   149(10):1755 1767, 2021), negatively impacting their quality of life and 
   increasing the risk of polypharmacy (Alwhaibi et al. in J Oncol Pharm Pract 
   26(5):1052 1059, 2020). This study evaluates the feasibility and acceptability of 
   acupuncture for the management of the pain-fatigue-sleep 
   disturbance-numbness/tingling symptom cluster in breast cancer survivors, and 
   investigates relationships between the symptom cluster and Traditional Chinese 
   Medicine (TCM) syndrome diagnosis. METHODS: This was a single-arm, 
   pre-test/post-test feasibility trial conducted at Chris O'Brien Lifehouse 
   Hospital, Australia. Breast cancer survivors who completed treatment and 
   experienced clinically significant levels of two or more symptoms (pain, fatigue, 
   sleep disturbance, numbness/tingling) were eligible to participate in the 
   individualized, pragmatic 6-week acupuncture intervention. The primary outcome 
   was feasibility and acceptability. Effectiveness was explored using a symptom 
   cluster mean score. RESULTS: Twenty women enrolled in the study over an 11-week 
   period and 90% completed the study. Most women agreed or completely agreed that 
   acupuncture was feasible (85%), acceptable (90%), and appropriate (90%). Both 
   mean and composite symptom cluster scores were significantly reduced (p < 0.001), 
   as were individual symptom scores in fatigue (p < 0.001), sleep disturbance 
   (p = 0.04), and numbness/tingling (p = 0.01). TCM syndromes most closely 
   associated with this symptom cluster were Spleen qi deficiency and Heart fire. No 
   adverse events were reported. CONCLUSION: This study demonstrated that 
   acupuncture was safe and feasible, justifying a powered randomized control trial. 
   Preliminary findings suggest beneficial effects of acupuncture for the management 
   of the pain-fatigue-sleep disturbance-numbness/tingling symptom cluster for women 
   with breast cancer. TCM syndromes identified in this trial may be used to guide 
   acupuncture treatment protocols. CLINICAL TRIAL REGISTRATION: This trial was 
   registered with the Australian New Zealand Clinical Trials Registry 
   (ACTRN12622000590763) on 21 April 2022.
C1 NICM Health Research Institute, Western Sydney University, Sydney, NSW, Australia. ki.kwon@lh.org.au.
   Chris O'Brien Lifehouse Hospital, Camperdown, NSW, Australia. ki.kwon@lh.org.au.
   NICM Health Research Institute, Western Sydney University, Sydney, NSW, Australia.
   Chris O'Brien Lifehouse Hospital, Camperdown, NSW, Australia.
   University of Sydney, Camperdown, NSW, Australia.
   Chris O'Brien Lifehouse Hospital, Camperdown, NSW, Australia.
   Chris O'Brien Lifehouse Hospital, Camperdown, NSW, Australia.
   University of Sydney, Camperdown, NSW, Australia.
   NICM Health Research Institute, Western Sydney University, Sydney, NSW, Australia.
   Chris O'Brien Lifehouse Hospital, Camperdown, NSW, Australia.
NR 0
TC 0
SN 1433-733
EI 0941-435
J9 Support Care Cancer
PD MAY 7
PY 2024
VL 32
IS 6
BP 332
EP 332
DI 10.1007/s00520-024-08529-9 
PG 0
WC Humans; Female; Breast Neoplasms; complications; Feasibility Studies; Middle Aged; Acupuncture Therapy; methods; Cancer Survivors; Sleep Wake Disorders; etiology; Fatigue; etiology; Adult; Aged; Australia; Quality of Life; Medicine, Chinese Traditional; methods; Pain Management; methods
UT PubMed:38713422
PM 38713422
DA 2024-05-07
ER

PT J
AU He, Y
   Liu, Y
   May, BH
   Zhang, AL
   Zhang, H
   Lu, C
   Yang, L
   Guo, X
   Xue, CC
AF He, Yihan
   Liu, Yihong
   May, Brian H
   Zhang, Anthony Lin
   Zhang, Haibo
   Lu, ChuanJian
   Yang, Lihong
   Guo, Xinfeng
   Xue, Charlie Changli
TI Effectiveness of acupuncture for cancer pain: protocol for an umbrella review and 
SO BMJ open
LA English
DT Journal Article
DE acupuncture; cancer pain; meta-analyses; umbrella review
AB INTRODUCTION: The National Comprehensive Cancer Network guidelines for adult 
   cancer pain indicate that acupuncture and related therapies may be valuable 
   additions to pharmacological interventions for pain management. Of the systematic 
   reviews related to this topic, some concluded that acupuncture was promising for 
   alleviating cancer pain, while others argued that the evidence was insufficient 
   to support its effectiveness. METHODS AND ANALYSIS: This review will consist of 
   three components: (1) synthesis of findings from existing systematic reviews; (2) 
   updated meta-analyses of randomised clinical trials and (3) analyses of results 
   of other types of clinical studies. We will search six English and four Chinese 
   biomedical databases, dissertations and grey literature to identify systematic 
   reviews and primary clinical studies. Two reviewers will screen results of the 
   literature searches independently to identify included reviews and studies. Data 
   from included articles will be abstracted for assessment, analysis and summary. 
   Two assessors will appraise the quality of systematic reviews using Assessment of 
   Multiple Systematic Reviews; assess the randomised controlled trials using the 
   Cochrane Collaboration's risk of bias tool and other types of studies according 
   to the Newcastle-Ottawa Scale. We will use 'summary of evidence' tables to 
   present evidence from existing systematic reviews and meta-analyses. Using the 
   primary clinical studies, we will conduct meta-analysis for each outcome, by 
   grouping studies based on the type of acupuncture, the comparator and the 
   specific type of pain. Sensitivity analyses are planned according to clinical 
   factors, acupuncture method, methodological characteristics and presence of 
   statistical heterogeneity as applicable. For the non-randomised studies, we will 
   tabulate the characteristics, outcome measures and the reported results of each 
   study. Consistencies and inconsistencies in evidence will be investigated and 
   discussed. Finally, we will use the Grading of Recommendations Assessment, 
   Development and Evaluation approach to evaluate the quality of the overall 
   evidence. ETHICS AND DISSEMINATION: There are no ethical considerations 
   associated with this review. The findings will be disseminated in peer-reviewed 
   journals or conference presentations. PROSPERO REGISTRATION NUMBER: 
   CRD42017064113.
C1 China-Australia International Research Center for Chinese Medicine, RMIT University, Melbourne, Victoria, Australia.
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial 
   China-Australia International Research Center for Chinese Medicine, RMIT University, Melbourne, Victoria, Australia.
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial 
   China-Australia International Research Center for Chinese Medicine, RMIT University, Melbourne, Victoria, Australia.
   China-Australia International Research Center for Chinese Medicine, RMIT University, Melbourne, Victoria, Australia.
   China-Australia International Research Center for Chinese Medicine, RMIT University, Melbourne, Victoria, Australia.
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial 
   China-Australia International Research Center for Chinese Medicine, RMIT University, Melbourne, Victoria, Australia.
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial 
   China-Australia International Research Center for Chinese Medicine, RMIT University, Melbourne, Victoria, Australia.
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial 
   China-Australia International Research Center for Chinese Medicine, RMIT University, Melbourne, Victoria, Australia.
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial 
   China-Australia International Research Center for Chinese Medicine, RMIT University, Melbourne, Victoria, Australia.
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial 
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD DEC 13
PY 2017
VL 7
IS 12
BP e018494
EP e018494
DI 10.1136/bmjopen-2017-018494 
PG 1
WC Humans; Acupuncture Therapy; Cancer Pain; therapy; Randomized Controlled Trials as Topic; Research Design; Systematic Reviews as Topic; Meta-Analysis as Topic
UT PubMed:29229658
PM 29229658
DA 2017-12-13
ER

PT J
AU Gao, XY
   Zhang, N
   Liu, K
   Xi, HQ
   Liu, Y
   He, X
   Han, S
   Zhu, B
AF Gao, Xin-Yan
   Zhang, Nan
   Liu, Kun
   Xi, Han-Qing
   Liu, Yun
   He, Xun
   Han, Shu
   Zhu, Bing
TI Peripheral neural mechanism of visceral pain and acupoint sensitization in 2, 4, 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acupoint sensitization; Colitis; Dorsal root ganglion; In vivo calcium imaging; Neuron
AB OBJECTIVES: To explore the neural mechanism of visceral pain and related somatic 
   (acupoints) sensitization by using in vivo calcium imaging of dorsal root ganglia 
   (DRG) neurons. METHODS: Eight BALB/c mice were randomly divided into control and 
   model groups, with 4 mice in each group. The colitis model was induced by 
   colorectal perfusion of 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) once daily 
   for 7 days. Mice of the control group received colorectal perfusion of normal 
   saline once daily for 7 days. The location and area of the somatic neurogenic 
   inflammation (cutaneous exudation of Evans blue ［EB］) of the 2 groups of mice 
   were observed after intravenous injection of EB. For pain behavioral tests, 
   sixteen C57BL/6J mice were randomly divided into control and model groups, with 8 
   mice in each group, and a Von Frey filament was used to stimulate the referred 
   somatic reactive regions in colitis mice, and the number of avoidance and paw 
   withdraw reaction within 10 tests was recorded. For in vivo DRG calcium imaging 
   tests, 24 Pirt-GCaMP6s transgenic mice were randomly and equally divided into 
   control group and colitis model group. The responses of the neurons in L6 or L4 
   DRG to colorectal distension (CRD), lower back brushing, or mechanical 
   stimulation at the hindpaw were observed using confocal fluorescence microscope. 
   RESULTS: Compared with the control group, the area of EB exudation spot in the 
   hindpaw and lower back regions was increased in the colitis model group (P<0.05), 
   and the avoidance or paw withdraw numbers induced by Von Frey stimulation at the 
   lower back and hindpaw were increased (P<0.01, P<0.05), indicating that colitis 
   induced regional skin (acupoints) sensitization in the lower back and hindpaw 
   regions. Compared with the control group, the percentage of L6 DRG neurons 
   activated by 60 mm Hg CRD in the colitis model mice were apparently increased 
   (P<0.01), the activated neurons mainly involved the medium-sized DRG neurons 
   (P<0.01). In Pirt-GCaMP6s transgenic mice, following brushing the skin of the 
   receptive field (lower back) of L6 DRG neurons, the fluorescence intensity of the 
   brushing-activated DRG neurons and small, medium and large-sized neurons were 
   significantly higher in the colitis model group than those in the control group 
   (P<0.001, P<0.01, P<0.05). After brushing and clamping the skin of the right 
   hindpaw (receptive field of L4 DRG neurons), the percentages of the activated L4 
   DRG neurons were obviously higher in the colitis model group than those in the 
   control group (P<0.01, P<0.05), while there were no significant changes in the 
   proportion of small, medium and large-sized neurons between the control and 
   colitis model groups. CONCLUSIONS: Colitis may lead to body surface sensitization 
   at the same and adjacent neuro-segments as well as to an increase of the number 
   and activity of the responsive lumbar DRG neurons, among which the L6 DRG neurons 
   at the same neuro-segment as the rectum colon showed an increase in the number of 
   responders and intensity of calcium fluorescence signal while L4 DRG neurons at 
   the level adjacent to the rectum colon showed an increase in the number of 
   responders, suggesting that there may be different mechanisms of peripheral 
   neural sensitization.
C1 Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China. gaoxy@mail.cintcm.ac.cn.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   School of Engineering Medicine, Beihang University, Beijing 100191.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China. zhubing@mail.cintcm.ac.cn.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD DEC 26
PY 2023
VL 48
IS 12
BP 1183
EP 1192
DI 10.13702/j.1000-0607.20221141 
PG 9
WC Mice; Animals; Visceral Pain; genetics; Calcium; Acupuncture Points; Mice, Inbred C57BL; Colitis; chemically induced; Trinitrobenzenes; Mice, Transgenic; Colorectal Neoplasms
UT PubMed:38146240
PM 38146240
DA 2023-12-26
ER

PT J
AU Li, D
   Yoo, JH
   Kim, SK
AF Li, Daxian
   Yoo, Ju Hyuk
   Kim, Sun Kwang
TI Long-Lasting and Additive Analgesic Effects of Combined Treatment of Bee Venom 
SO Toxins
LA English
DT Journal Article
DE allodynia; bee venom acupuncture; combination therapy; paclitaxel; venlafaxine
AB Paclitaxel, a primary chemotherapeutic agent used to treat numerous solid 
   malignancies, is commonly associated with debilitating peripheral neuropathy. 
   However, a satisfactory gold-standard monotherapy for this neuropathic pain is 
   not currently available. A combination strategy of two or more medications with 
   different properties may achieve more beneficial effects than monotherapy. Thus, 
   we investigated the analgesic efficacies and spinal mechanisms of the combination 
   strategy, including bee venom acupuncture (BVA) and venlafaxine (VLX) against 
   paclitaxel-induced allodynia in mice. Four intraperitoneal infusions of 
   paclitaxel on alternating days (2 mg/kg/day) induced cold and mechanical 
   allodynia for at least 1 week as assessed using acetone and the von Frey hair 
   test, respectively. Co-treatment of BVA (1.0 mg/kg, s.c., ST36) with VLX (40 
   mg/kg, i.p.) at the medium dose produced a longer-lasting and additive effect 
   than each monotherapy at the highest dose (BVA, 2.5 mg/kg; VLX, 60 mg/kg). Spinal 
   pre-administration of idazoxan (α(2)-adrenergic receptor antagonist, 10 μg), 
   methysergide (mixed 5-HT(1)/5-HT(2) receptor antagonist, 10 μg), or MDL-72222 
   (5-HT(3) receptor antagonist, 10 μg) abolished this analgesia. These results 
   suggest that the combination therapy with BVA and VLX produces long-lasting and 
   additive analgesic effects on paclitaxel-induced allodynia, via the spinal 
   noradrenergic and serotonergic mechanism, providing a promising clinical 
   strategy.
C1 Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
   Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
   Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
   Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul 
   Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
NR 0
TC 0
SN 2072-665
EI 
J9 Toxins (Basel)
PD OCT 2
PY 2020
VL 12
IS 10
BP 
EP 
DI 10.3390/toxins12100620 
PG 0
WC Acupuncture Therapy; Analgesics; pharmacology; Animals; Bee Venoms; administration & dosage; Combined Modality Therapy; Disease Models, Animal; Hyperalgesia; chemically induced; Male; Mice, Inbred C57BL; Paclitaxel; Pain Threshold; drug effects; Serotonin and Noradrenaline Reuptake Inhibitors; pharmacology; Spinal Cord; drug effects; Venlafaxine Hydrochloride; pharmacology
UT PubMed:32998357
PM 32998357
DA 2020-10-02
ER

PT J
AU Li, KW
   Chu, HR
   Ruan, JR
   Wang, JJ
   Chen, JY
   Zhu, SS
   Zou, L
   Liao, LM
   Tong, TT
AF Li, Kui-Wu
   Chu, Hao-Ran
   Ruan, Jing-Ru
   Wang, Jiao-Jiao
   Chen, Jin-Yu
   Zhu, Shan-Shan
   Zou, Ling
   Liao, Lu-Min
   Tong, Ting-Ting
TI [Effect of moxibustion on immune function homeostasis in rats with diarrhea 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE diarrhea irritable bowel syndrome; immune function; moxibustion; stem cell factor/tyrosine kinase receptor (SCF/c-kit) signaling pathway
AB OBJECTIVE: To observe the effects of moxibustion on the stem cell factor 
   (SCF)/tyrosine kinase receptor (c-kit) signaling pathway and immune function in 
   rats with diarrhea irritable bowel syndrome (IBS-D), and to explore the mechanism 
   of moxibustion for IBS-D. METHODS: Among 52 young rats born from 6 healthy 
   pregnant SPF rats, 12 rats were randomly selected into the normal group, and the 
   remaining 40 rats were treated with the three-factor combination method of 
   maternal separation, acetic acid enema and chronic restraint stress to establish 
   the IBS-D rat model. Thirty-six rats with successful IBS-D model were randomly 
   divided into a model group, a moxibustion group, and a medication group, 12 rats 
   in each group. The rats in the moxibustion group were treated with suspension 
   moxibustion at "Tianshu" (ST 25) and "Shangjuxu" (ST 37); the rats in the 
   medication group were treated with intragastric administration of rifaximin 
   suspension (150 mg/kg). All the treatments were given once a day for 7 
   consecutive days. The body mass, loose stool rate (LSR), the minimum volume 
   threshold when abdominal withdrawal reflex (AWR) scored 3 were measured before 
   acetic acid enema (35 days old), after modeling (45 days old), and after 
   intervention (53 days old). After intervention (53 days old), HE staining was 
   used to observe the morphology of colon tissue, and spleen and thymus 
   coefficients were measured; ELISA method was used to detect serum inflammatory 
   factors (tumor necrosis factor a [TNF-a], interleukin [IL]-10, IL-8), 
   T-lymphocyte subsets (CD(+)(4), CD(+)(8), CD(+)(45)), value of CD(+)(4)/CD(+)(8) 
   and immune globulin (IgA, IgG, IgM); real-time PCR method and Western blot method 
   was used to detect the expression of SCF, c-kit mRNA and protein in colon tissue; 
   immunofluorescence staining method were used to detect positive expression of SCF 
   and c-kit. RESULTS: After intervention, compared with the normal group, in the 
   model group, the body mass and the minimum volume threshold when AWR scored 3 
   were decreased (P<0.01), LSR, spleen and thymus coefficients, serum levels of 
   TNF-α, IL-8, CD(+)(4), CD(+)(45), CD(+)(4)/CD(+)(8), IgA, IgG, IgM were increased 
   (P<0.01), serum IL-10 level and protein and mRNA expression of SCF and c-kit in 
   colon tissue were decreased (P<0.01), and the positive expression of SCF and 
   c-kit was decreased (P<0.01). Compared with the model group, in the moxibustion 
   group and the medication group, the body mass and the minimum volume threshold 
   when AWR scored 3 were increased (P<0.01, P<0.05), LSR, spleen and thymus 
   coefficients, serum levels of TNF-α, IL-8, CD(+)(4), CD(+)(8), CD(+)(45), 
   CD(+)(4)/CD(+)(8), IgA, IgG, IgM were decreased (P<0.01, P<0.05), serum IL-10 
   level and protein and mRNA expression of SCF and c-kit in colon tissue were 
   increased (P<0.01), and the positive expression of SCF and c-kit was increased 
   (P<0.01). Compared with the medication group, in the moxibustion group, the level 
   of serum CD(+)(4) was decreased (P<0.05), the value of CD(+)(4)/CD(+)(8) was 
   increased (P<0.01), and there was no significant difference in other indexes 
   (P>0.05). The expression of SCF and c-kit mRNA was positively correlated with the 
   minimum volume threshold when AWR scored 3 and IL-10 (P<0.01), and negatively 
   correlated with remaining indexes (P<0.01, P<0.05). CONCLUSION: Moxibustion could 
   reduce visceral hypersensitivity, improve symptoms of abdominal pain and diarrhea 
   in IBS-D rats, and its mechanism may be related to up-regulation of the 
   expression of SCF/c-kit signaling pathway and improvement of IBS-D immune 
   function.
C1 Second Clinical Medical College of Anhui University of CM, Hefei 230061, China.
   Famous Doctor Clinic, Second Affiliated Hospital of Anhui University of CM/Anhui Acupuncture and Moxibustion Hospital, Hefei 230061
   Clinical Research Instituteof Acupuncture and Moxibustion of Anhui Academy of TCM, Hefei 230061
   AnhuiClinical Medical Research Center of Acupuncture and Moxibustion, Hefei 230061.
   Second Clinical Medical College of Anhui University of CM, Hefei 230061, China.
   Second Clinical Medical College of Anhui University of CM, Hefei 230061, China.
   Second Clinical Medical College of Anhui University of CM, Hefei 230061, China.
   Second Clinical Medical College of Anhui University of CM, Hefei 230061, China.
   Second Clinical Medical College of Anhui University of CM, Hefei 230061, China.
   Second Clinical Medical College of Anhui University of CM, Hefei 230061, China.
   Second Clinical Medical College of Anhui University of CM, Hefei 230061, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD FEB 23
PY 2023
VL 43
IS 2
BP 177
EP 85
DI 10.13703/j.0255-2930.20220108-k0007 
PG -92
WC Rats; Animals; Irritable Bowel Syndrome; therapy; Moxibustion; methods; Rats, Sprague-Dawley; Interleukin-10; Interleukin-8; Maternal Deprivation; Tumor Necrosis Factor-alpha; Diarrhea; Signal Transduction; Homeostasis; Receptor Protein-Tyrosine Kinases; Immunity; Immunoglobulin A; Immunoglobulin M
UT PubMed:36808512
PM 36808512
DA 2023-02-23
ER

PT J
AU MacPherson, H
   Tilbrook, HE
   Richmond, SJ
   Atkin, K
   Ballard, K
   Bland, M
   Eldred, J
   Essex, HN
   Hopton, A
   Lansdown, H
   Muhammad, U
   Parrott, S
   Torgerson, D
   Wenham, A
   Woodman, J
   Watt, I
AF MacPherson, Hugh
   Tilbrook, Helen E
   Richmond, Stewart J
   Atkin, Karl
   Ballard, Kathleen
   Bland, Martin
   Eldred, Janet
   Essex, Holly N
   Hopton, Ann
   Lansdown, Harriet
   Muhammad, Usman
   Parrott, Steve
   Torgerson, David
   Wenham, Aniela
   Woodman, Julia
   Watt, Ian
TI Alexander Technique Lessons, Acupuncture Sessions or usual care for patients with 
SO Trials
LA English
DT Journal Article
AB BACKGROUND: Chronic neck pain is a common condition in the adult population. More 
   research is needed to evaluate interventions aiming to facilitate beneficial 
   long-term change. We propose to evaluate the effect of Alexander Technique 
   lessons and acupuncture in a rigorously conducted pragmatic trial with an 
   embedded qualitative study. METHODS/DESIGN: We will recruit 500 patients who have 
   been diagnosed with neck pain in primary care, who have continued to experience 
   neck pain for at least three months with 28% minimum cut-off score on the 
   Northwick Park Neck Pain Questionnaire (NPQ). We will exclude patients with 
   serious underlying pathology, prior cervical spine surgery, history of psychosis, 
   rheumatoid arthritis, ankylosing spondylitis, osteoporosis, haemophilia, cancer, 
   HIV or hepatitis, or with alcohol or drug dependency currently or in the last 12 
   months, or actively pursuing compensation or with pending litigation.The York 
   Trials Unit will randomly allocate participants using a secure computer-based 
   system. We will use block randomisation with allocation to each intervention arm 
   being unambiguously concealed from anyone who might subvert the randomisation 
   process.Participants will be randomised in equal proportions to Alexander 
   Technique lessons, acupuncture or usual care alone. Twenty 30-minute Alexander 
   Technique lessons will be provided by teachers registered with the Society of 
   Teachers of the Alexander Technique and twelve 50-minute sessions of acupuncture 
   will be provided by acupuncturists registered with the British Acupuncture 
   Council. All participants will continue to receive usual GP care.The primary 
   outcome will be the NPQ at 12 months, with the secondary time point at 6 months, 
   and an area-under-curve analysis will include 3, 6 and 12 month time-points. 
   Adverse events will be documented. Potential intervention effect modifiers and 
   mediators to be explored include: self-efficacy, stress management, and the 
   incorporation of practitioner advice about self-care and lifestyle. Qualitative 
   material will be used to address issues of safety, acceptability and factors that 
   impact on longer term outcomes. DISCUSSION: This study will provide robust 
   evidence on whether there are significant clinical benefits to patients, economic 
   benefits demonstrating value for money, and sufficient levels of acceptability 
   and safety. TRIAL REGISTRATION: Current Controlled Trials ISRCTN15186354.
C1 Department of Health Sciences, University of York, York, UK. hugh.macpherson@york.ac.uk
NR 0
TC 0
SN 1745-621
EI 
J9 Trials
PD JUL 12
PY 2013
VL 14
IS 
BP 209
EP 209
DI 10.1186/1745-6215-14-209 
PG 0
WC Acupuncture Therapy; economics; Area Under Curve; Chronic Pain; diagnosis; Clinical Protocols; Cost-Benefit Analysis; England; Health Care Costs; Humans; Neck Pain; diagnosis; Pain Measurement; Patient Selection; Physical Therapy Modalities; economics; Predictive Value of Tests; Qualitative Research; Research Design; Surveys and Questionnaires; Time Factors; Treatment Outcome
UT PubMed:23841901
PM 23841901
DA 2013-07-12
ER

PT J
AU Yeh, CH
   Chien, LC
   Lin, WC
   Bovbjerg, DH
   van, Londen GJ
AF Yeh, Chao Hsing
   Chien, Lung-Chang
   Lin, Wei-Chun
   Bovbjerg, Dana Howard
   van Londen, G J
TI Pilot Randomized Controlled Trial of Auricular Point Acupressure to Manage 
SO Cancer nursing
LA English
DT Journal Article
AB BACKGROUND: Current management for a symptom cluster of pain, fatigue, and 
   disturbed sleep in breast cancer patients has limited effects. OBJECTIVE: The 
   purposes of this prospective, randomized controlled pilot study were to (1) 
   assess the feasibility and tolerability of auricular point acupressure (APA) 
   intervention to manage pain, fatigue, and sleep disturbance in breast cancer 
   patients and (2) provide an initial appraisal of effect size as compared with a 
   control intervention. METHODS: Thirty-one participants were randomized into 
   either an active APA group (n = 16) or a control APA group (n = 15), which 
   included the sham APA treatment not related to the symptoms. All participants 
   received the APA once a week for 4 weeks. Self-report measures were obtained at 
   baseline, weekly during intervention, at end of intervention, and at a 1-month 
   follow-up. RESULTS: For the 4-week of APA treatment, the retention rate was 88% 
   for the active APA group and 73% for the control APA group. After 4 weeks of APA, 
   participants in the active APA treatment had reported a reduction of 71% in pain, 
   44% in fatigue, 31% in sleep disturbance, and 61% in interference with daily 
   activities. The control APA group experienced some moderate reduction in these 
   symptoms. CONCLUSION: Given that this was a pilot study with a small sample size, 
   results must be interpreted with caution. IMPLICATIONS FOR PRACTICE: Our results 
   suggest that APA may provide an inexpensive and effective complementary approach 
   for the management of symptom clusters for breast cancer patients, and further 
   study is warranted.
C1 Author Affiliations: School of Nursing, University of Pittsburgh, Pennsylvania (Drs Yeh and Lin)
   Department of Biostatistics, University of Texas, San Antonio(Dr Chien)
   Biobehavioral Oncology Program, University of Pittsburgh,Pennsylvania (Dr Bovbjerg)
   and Division of Hematology/Oncology, Department ofMedicine, University of Pittsburgh Medical Center, Pennsylvania (Dr van Londen).
NR 0
TC 0
SN 1538-980
EI 
J9 Cancer Nurs
PD SEP 22
PY 2015
VL 39
IS 5
BP 402
EP 10
DI 10.1097/NCC.0000000000000303 
PG -392
WC Acupuncture, Ear; methods; Adult; Aged; Aged, 80 and over; Breast Neoplasms; complications; Fatigue; etiology; Female; Humans; Middle Aged; Pain Management; methods; Pilot Projects; Placebo Effect; Sleep
UT PubMed:26390073
PM 26390073
DA 2015-09-22
ER

PT J
AU Chen, ZH
   Zheng, QK
   Chen, SJ
   Li, X
   Lian, XW
AF Chen, Zhen-Hua
   Zheng, Qi-Kai
   Chen, Shui-Jin
   Li, Xiang
   Lian, Xiao-Wen
TI [Warming acupuncture combined with "three steps and seven methods" of tuina for 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE chronic nonspecific low back pain; three steps and seven methods; tuina; warming acupuncture; yang deficiency and cold-dampness blockage
AB OBJECTIVE: To compare the clinical efficacy and possible mechanism of warming 
   acupuncture combined with "three steps and seven methods" of tuina and simple 
   "three steps and seven methods" of tuina in treatment of chronic nonspecific low 
   back pain (NLBP) of yang deficiency and cold-dampness blockage. METHODS: A total 
   of 138 patients were randomized into an observation group (69 cases, 5 cases 
   dropped off) and a control group (69 cases, 7 cases dropped off). In the control 
   group, "three steps and seven methods" of tuina was applied. On the basis of the 
   treatment in the control group, warming acupuncture was applied at Shenshu (BL 
   23), Yaoyangguan (GV 3), Mingmen (GV 4), Weizhong (BL 40) and ashi points. The 
   treatment was given once a day, 6 times a week for 3 weeks in both groups. Before 
   and after treatment, the short form of McGill pain questionnaire (SF-MPQ) score, 
   Oswestry disability index (ODI) score, finger-to-floor distance (FFD), Schober 
   test distance, fear-avoidance beliefs questionnaire (FABQ) score and yang 
   deficiency and cold-dampness blockage score were observed, the serum levels of 
   tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and thromboxane B(2) 
   (TXB(2)) were detected in both groups. The recurrence rate was evaluated in 
   follow-up of 6 months after treatment. RESULTS: After treatment, the scores of 
   PRI, PPI, VAS, ODI, FABQ and FFD, yang deficiency and cold-dampness blockage 
   scores were decreased compared before treatment in both groups (P<0.01), and 
   those in the observation group were lower than the control group (P<0.01); the 
   Schober test distances were increased compared before treatment in both groups 
   (P<0.01), and that in the observation group was larger than the control group 
   (P<0.01). After treatment, the serum levels of TNF-α, IL-1β, IL-6 and TXB(2) were 
   decreased compared before treatment in both groups (P<0.01), and those in the 
   observation group were lower than the control group (P<0.01). In follow-up, the 
   recurrence rate was 12.8% (6/47) in the observation group, which was lower than 
   34.3% (12/35) in the control group (P<0.05). CONCLUSION: Warming acupuncture 
   combined with "three steps and seven methods" of tuina can effectively alleviate 
   pain in patients with chronic NLBP of yang deficiency and cold-dampness blockage, 
   improve activity and dysfunction of waist, the clinical efficacy is superior to 
   simple "three steps and seven methods" of tuina, its mechanism may be relate to 
   the inhibition of inflammatory reaction.
C1 Department of Tuina, Rehabilitation Hospital Affiliated to Fujian University of TCM, Fuzhou 350003, China
   Fujian Provincial Key Laboratory of RehabilitationTechnology, Fuzhou 350003.
   Department of Tuina, Rehabilitation Hospital Affiliated to Fujian University of TCM, Fuzhou 350003, China
   Fujian Provincial Key Laboratory of RehabilitationTechnology, Fuzhou 350003.
   Department of Tuina, Rehabilitation Hospital Affiliated to Fujian University of TCM, Fuzhou 350003, China
   Fujian Provincial Key Laboratory of RehabilitationTechnology, Fuzhou 350003.
   College of Rehabilitation Medicine, Fujian University of TCM.
   Department of Tuina, Rehabilitation Hospital Affiliated to Fujian University of TCM, Fuzhou 350003, China
   Fujian Provincial Key Laboratory of RehabilitationTechnology, Fuzhou 350003.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAY 12
PY 2022
VL 42
IS 5
BP 505
EP 10
DI 10.13703/j.0255-2930.20210622-k0001 
PG -495
WC Acupuncture Points; Acupuncture Therapy; Humans; Interleukin-6; Low Back Pain; therapy; Treatment Outcome; Tumor Necrosis Factor-alpha; Yang Deficiency; therapy
UT PubMed:35543940
PM 35543940
DA 2022-05-12
ER

PT J
AU Mao, JJ
AF Mao, Jun J
TI Reply to Sham procedure inadequate.
SO Cancer
LA English
DT Letter
C1 Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University ofPennsylvania, Philadelphia, Pennsylvania.
NR 0
TC 0
SN 1097-014
EI 
J9 Cancer
PD JAN 8
PY 2015
VL 121
IS 7
BP 1148
EP 9
DI 10.1002/cncr.29115 
PG -1139
WC Anxiety; therapy; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Depression; therapy; Electroacupuncture; methods; Fatigue; therapy; Female; Humans; Sleep Wake Disorders; therapy
UT PubMed:25565387
PM 25565387
DA 2015-01-08
ER

PT J
AU Mahasti, S
   Caroline, B
   Bernard, A
   Yunfen, LI
   Jianyun, N
   Dequan, L
   Dedian, C
   Chunxin, C
   Estevez, L
   Wenhui, LI
   Armand, JP
   Miansheng, Z
   Liya, JU
AF Mahasti, Saghachian
   Caroline, Barry
   Bernard, Asselain
   Yunfen, L I
   Jianyun, Nie
   Dequan, Liu
   Dedian, Chen
   Chunxin, Chen
   Estevez, Laura
   Wenhui, L I
   Armand, Jean-Pierre
   Miansheng, Zhu
   Liya, J U
TI An international multicentric phase Ⅲ randomized controlled trial of 
SO Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
LA English
DT Journal Article
DE breast neoplasms; chemotherapy, adjuvant; clinical protocols; fatigue; immunity; time-acupoints-space acupuncture
AB OBJECTIVE: To determine the difference in prevention of chemotherapy-induced 
   fatigue between time-acupoints-space acupuncture (ATAS) administered weekly 
   compared to sham acupuncture and non-acupuncture in patients with early breast 
   cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide (EC) 
   followed by paclitaxel, as measured by the multi-dimensional fatigue inventory 
   (MFI) over the previous week and Visual Analogue Scale measuring fatigue (VAS-F), 
   and to evaluate the effects of ATAS on self-reported neuropathy pain, sleep, 
   anxiety and depression. METHODS: In this multicenter clinical trial, we have 
   randomized patients into 3 groups: ATAS, Sham and non-acupuncture with an unequal 
   randomization of 2∶1∶1. A cloud related electronical clinical report form and 
   smartphone platform was established for data entry. Patients with a history of 
   stage Ⅰ-Ⅲ breast cancer scheduled to receive adjuvant chemotherapy. Acupuncture 
   will be delivered once a week during chemotherapy with VAS-F evaluation. In order 
   to qualify and quantify the mechanism of fatigue induced by chemotherapy with or 
   without acupuncture, an evaluation of immune profiling was incorporate in this 
   study. RESULTS: The presence and seriousness of chemotherapy-induced fatigue 
   should be considered in therapeutic programs for early breast cancer treatment. 
   Fatigue induced by adjuvant chemotherapy in patients with breast cancer remains a 
   major concern affecting the quality of life significantly. Unfortunately, we do 
   not have effective pharmacological interventions yet. And clinical trials of 
   acupuncture in preventing chemotherapy-induced fatigue in patients with early 
   breast cancer have not been reported. CONCLUSION: The findings of the trial will 
   allow us to determine the effects of acupuncture treatment approach. We will also 
   be able to confirm whether ATAS is better than sham acupuncture and 
   non-acupuncture treatments.
C1 Institute Gustave Roussy, Paris, France.
   Research Center of Epidemiology and public health, Paris, France.
   Institute Curie of Paris, Paris, France.
   Yunnan Cancer Hospital, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
   Yunnan Cancer Hospital, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
   Yunnan Cancer Hospital, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
   Yunnan Cancer Hospital, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
   MD Anderson Cancer Hospital, Madrid, Spain.
   MD Anderson Cancer Hospital, Madrid, Spain.
   Yunnan Cancer Hospital, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
   Institute Gustave Roussy, Paris, France.
   ARIATAS Association pour la Recherche et l' Information de l' Acupuncture Time-Acupoints-Space, Paris, France.
   Yunnan Zhu's expert workstation, National famous traditional Chinese medicine 
   PreciMed Platform Europe, Paris, France.
NR 0
TC 0
SN 2589-451
EI 0255-292
J9 J Tradit Chin Med
PD APR 28
PY 2022
VL 42
IS 2
BP 289
EP 295
DI 10.19852/j.cnki.jtcm.2022.02.008 
PG 6
WC Acupuncture Points; Acupuncture Therapy; methods; Antineoplastic Agents; adverse effects; Breast Neoplasms; drug therapy; Clinical Trials, Phase III as Topic; Female; Humans; Multicenter Studies as Topic; Quality of Life; Randomized Controlled Trials as Topic
UT PubMed:35473351
PM 35473351
DA 2022-04-28
ER

PT J
AU Li, S
   Huang, J
   Guo, Y
   Wang, J
   Lu, S
   Wang, B
   Gong, Y
   Qin, S
   Zhao, S
   Wang, S
   Liu, Y
   Fang, Y
   Guo, Y
   Xu, Z
   Ulloa, L
AF Li, Shanshan
   Huang, Jin
   Guo, Yi
   Wang, Jiaqi
   Lu, Shanshan
   Wang, Bin
   Gong, Yinan
   Qin, Siru
   Zhao, Suhong
   Wang, Shenjun
   Liu, Yangyang
   Fang, Yuxin
   Guo, Yongming
   Xu, Zhifang
   Ulloa, Luis
TI PAC1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune Protection 
SO Frontiers in immunology
LA English
DT Journal Article
DE chemotherapy; electroacupuncture; hematopoiesis; immunosuppression; neuromodulation; neurotoxic
AB Platinum-based chemotherapy is an effective treatment used in multiple tumor 
   treatments, but produces severe side effects including neurotoxicity, anemia, and 
   immunosuppression, which limits its anti-tumor efficacy and increases the risk of 
   infections. Electroacupuncture (EA) is often used to ameliorate these side 
   effects, but its mechanism is unknown. Here, we report that EA on ST36 and SP6 
   prevents cisplatin-induced neurotoxicity and immunosuppression. EA induces 
   neuroprotection, prevents pain-related neurotoxicity, preserves bone marrow (BM) 
   hematopoiesis, and peripheral levels of leukocytes. EA activates sympathetic BM 
   terminals to release pituitary adenylate cyclase activating polypeptide (PACAP). 
   PACAP-receptor PAC1-antagonists abrogate the effects of EA, whereas PAC1-agonists 
   mimic EA, prevent neurotoxicity, immunosuppression, and preserve BM hematopoiesis 
   during cisplatin chemotherapy. Our results indicate that PAC1-agonists may 
   provide therapeutic advantages during chemotherapy to treat patients with 
   advanced neurotoxicity or neuropathies limiting EA efficacy.
C1 Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese 
   National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin's Clinical Research Center for Cancer, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University, Durham, NC, United States.
NR 0
TC 0
SN 1664-322
EI 
J9 Front Immunol
PD SEP 24
PY 2021
VL 12
IS 
BP 714244
EP 714244
DI 10.3389/fimmu.2021.714244 
PG 0
WC Animals; Bone Marrow Cells; metabolism; Chemotherapy-Induced Febrile Neutropenia; Cisplatin; pharmacology; Disease Management; Disease Models, Animal; Electroacupuncture; methods; Hematopoiesis; genetics; Humans; Immunomodulation; genetics; Leukopenia; Mice; Neoplasms; genetics; Neuroimmunomodulation; genetics; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type 
UT PubMed:34552585
PM 34552585
DA 2021-09-24
ER

PT J
AU Hershman, DL
   Unger, JM
   Crew, K
AF Hershman, Dawn L
   Unger, Joseph M
   Crew, Katherine
TI Acupuncture for Aromatase Inhibitor-Related Joint Pain Among Breast Cancer 
SO JAMA
LA English
DT Letter
C1 Columbia University Medical Center, New York, New York.
   Fred Hutchinson Cancer Research Center, Seattle, Washington.
   Columbia University Medical Center, New York, New York.
NR 0
TC 0
SN 1538-359
EI 
J9 JAMA
PD DEC 5
PY 2018
VL 320
IS 21
BP 2270
EP 2271
DI 10.1001/jama.2018.16744 
PG 1
WC Acupuncture Therapy; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Humans; Personality
UT PubMed:30512095
PM 30512095
DA 2018-12-05
ER

PT J
AU Liu, C
   Zhang, H
   Sun, C
AF Liu, Cun
   Zhang, Heng
   Sun, Changgang
TI Acupuncture for Aromatase Inhibitor-Related Joint Pain Among Breast Cancer 
SO JAMA
LA English
DT Letter
C1 College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
   College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
   Weifang Traditional Chinese Hospital, Weifang, China.
NR 0
TC 0
SN 1538-359
EI 
J9 JAMA
PD DEC 5
PY 2018
VL 320
IS 21
BP 2270
EP 2270
DI 10.1001/jama.2018.16740 
PG 0
WC Acupuncture Therapy; Aromatase; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Female; Humans
UT PubMed:30512093
PM 30512093
DA 2018-12-05
ER

PT J
AU Mao, JJ
   Farrar, JT
AF Mao, Jun J
   Farrar, John T
TI Acupuncture for Aromatase Inhibitor-Related Joint Pain Among Breast Cancer 
SO JAMA
LA English
DT Letter
C1 Memorial Sloan Kettering Cancer Center, New York, New York.
   University of Pennsylvania, Philadelphia.
NR 0
TC 0
SN 1538-359
EI 
J9 JAMA
PD DEC 5
PY 2018
VL 320
IS 21
BP 2269
EP 2270
DI 10.1001/jama.2018.16736 
PG 1
WC Acupuncture Therapy; Aromatase; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Female; Humans
UT PubMed:30512092
PM 30512092
DA 2018-12-05
ER

PT J
AU Ba, D
   Guo, Y
   Chen, B
   Zhai, J
   Lv, X
   Wang, B
   Chen, A
   Fu, L
   Chen, Z
   Guo, Y
AF Ba, Dongsheng
   Guo, Yang
   Chen, Bo
   Zhai, Jingbo
   Lv, Xiaoyan
   Wang, Bin
   Chen, Aoxiang
   Fu, Liyuan
   Chen, Zelin
   Guo, Yi
TI [Investigation on cognition for insomnia and preference for acupuncture in breast 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE breast cancer survivors; cognition for insomnia; in-depth interview; preference for acupuncture
AB OBJECTIVE: To understand the cognition for insomnia and preference for 
   acupuncture in breast cancer survivors based on the in-depth interview. METHODS: 
   Thirty breast cancer survivors with insomnia symptoms were collected for in-depth 
   interview. The interview questions included three aspects, i.e. sleep 
   expectation, cognition for insomnia (discomfort caused by insomnia, and 
   underlying inducing factors of insomnia) and the preference for acupuncture 
   (treatment methods used in the past, the reasons for not choosing acupuncture, 
   and the tendency of acupuncture treatment). Using Colaizzi content analysis 
   method, the data was analyzed. RESULTS: Regarding sleep expectation, most breast 
   cancer survivors with insomnia symptoms were able to maintain normal activity in 
   daytime. Insomnia symptoms often led to fatigue, and the inducing factors of 
   insomnia referred to the treatment with endocrine therapy, anticipatory anxiety 
   and inadequate sleep hygiene. All of the patients had received pharmacotherapy. 
   The use proportion of non-pharmacological therapies was relatively low, and 
   acupuncture was not chosen due to "not familiar with" and "fear of pain". 
   Concerning to the preference for acupuncture, patients preferred the therapeutic 
   methods of acupuncture with mild pain sensation and gentle stimulation; and the 
   treatment should be more acceptable if delivered 2 or 3 times a week. CONCLUSION: 
   Breast cancer survivors have the expectations for sleep, and are willing to 
   receive the treatment with medication for their sleep disorders. Because of lack 
   of the knowledge for acupuncture effect on insomnia and fear of strong needling 
   sensation, a part of patients are unwilling to be treated with acupuncture 
   therapy, but they are expected to receive the treatment with acupuncture while 
   feeling more comfortable.
C1 School of Acupuncture-Moxibustion and Tuina, Tianjin University of TCM, Tianjin 301617, China.
   Department of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of TCM.
   School of Acupuncture-Moxibustion and Tuina, Tianjin University of TCM, Tianjin 301617, China
   Department of Acupuncture and Moxibustion for Encephalopathy,Tianjin Binhai New Area Hospital of TCM, Tianjin 300451
   National ClinicalResearch Center for Chinese Medicine Acupuncture, Tianjin 301617.
   School of Public Health and Health Sciences, Tianjin University of TCM.
   School of Acupuncture-Moxibustion and Tuina, Tianjin University of TCM, Tianjin 301617, China.
   Department of Integrated Chinese and Western Medicine, Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center for Cancer.
   Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center for Cancer.
   School of Acupuncture-Moxibustion and Tuina, Tianjin University of TCM, Tianjin 301617, China.
   School of Acupuncture-Moxibustion and Tuina, Tianjin University of TCM, Tianjin 301617, China
   National Clinical Research Center for Chinese MedicineAcupuncture, Tianjin 301617.
   School of Acupuncture-Moxibustion and Tuina, Tianjin University of TCM, Tianjin 301617, China
   National Clinical Research Center for Chinese MedicineAcupuncture, Tianjin 301617.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD SEP 25
PY 2024
VL 44
IS 9
BP 1023
EP 8
DI 10.13703/j.0255-2930.20231207-0001 
PG -1015
WC Humans; Sleep Initiation and Maintenance Disorders; therapy; Female; Acupuncture Therapy; Breast Neoplasms; therapy; Middle Aged; Adult; Cancer Survivors; psychology; Cognition; Aged; Sleep; Patient Preference
UT PubMed:39318293
PM 39318293
DA 2024-09-25
ER

PT J
AU Bao, T
   Cai, L
   Giles, JT
   Gould, J
   Tarpinian, K
   Betts, K
   Medeiros, M
   Jeter, S
   Tait, N
   Chumsri, S
   Armstrong, DK
   Tan, M
   Folkerd, E
   Dowsett, M
   Singh, H
   Tkaczuk, K
   Stearns, V
AF Bao, Ting
   Cai, Ling
   Giles, Jon T
   Gould, Jeff
   Tarpinian, Karineh
   Betts, Kelly
   Medeiros, Michelle
   Jeter, Stacie
   Tait, Nancy
   Chumsri, Saranya
   Armstrong, Deborah K
   Tan, Ming
   Folkerd, Elizabeth
   Dowsett, Mitch
   Singh, Harvinder
   Tkaczuk, Kate
   Stearns, Vered
TI A dual-center randomized controlled double blind trial assessing the effect of 
SO Breast cancer research and treatment
LA English
DT Journal Article
AB Up to 50 % of women receiving aromatase inhibitor (AI) complain of AI-associated 
   musculoskeletal symptoms (AIMSS) and 15 % discontinue treatment. We conducted a 
   randomized, sham-controlled trial to evaluate whether acupuncture improves AIMSS 
   and to explore potential mechanisms. Postmenopausal women with early stage breast 
   cancer, experiencing AIMSS were randomized to eight weekly real or sham 
   acupuncture sessions. We evaluated changes in the Health Assessment Questionnaire 
   Disability Index (HAQ-DI) and pain visual analog scale (VAS) following the 
   intervention compared to baseline. Serum estradiol, β-endorphin, and 
   proinflammatory cytokine concentrations were measured pre and post-intervention. 
   We enrolled 51 women of whom 47 were evaluable, including 23 randomized to real 
   and 24 to sham acupuncture. Baseline characteristics were balanced between groups 
   with the exception of a higher HAQ-DI score in the real acupuncture group (p = 
   0.047). We did not observe a statistically significant difference in reduction of 
   HAQ-DI (p = 0.30) or VAS (p = 0.31) between the two groups. Following eight 
   weekly treatments, we observed a statistically significant reduction of IL-17 (p 
   ≤ 0.009) in both groups. No significant modulation was seen in estradiol, 
   β-endorphin, or other proinflammatory cytokine concentrations in either group. We 
   did not observe a significant difference in AIMSS changes between real and sham 
   acupuncture. As sham acupuncture used in this study may not be equivalent to 
   placebo, further studies with a non-acupuncture arm may be required to establish 
   whether acupuncture is beneficial for the treatment of AIMSS.
C1 University of Maryland Greenebaum Cancer Center, Baltimore, MD 20201, USA. tbao@umm.edu
NR 0
TC 0
SN 1573-721
EI 0167-680
J9 Breast Cancer Res Treat
PD FEB 9
PY 2013
VL 138
IS 1
BP 167
EP 74
DI 10.1007/s10549-013-2427-z 
PG -93
WC Acupuncture Therapy; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; adverse effects; Aromatase Inhibitors; adverse effects; Breast Neoplasms; blood; Female; Humans; Inflammation Mediators; blood; Middle Aged; Musculoskeletal Pain; chemically induced; Time Factors; Treatment Outcome; beta-Endorphin; blood
UT PubMed:23393007
PM 23393007
DA 2013-02-09
ER

PT J
AU Kim, HS
   Park, IH
   Seo, SH
   Han, I
   Cho, HS
AF Kim, Han-Soo
   Park, Il Hyung
   Seo, Sung Hwa
   Han, Ilkyu
   Cho, Hwan Seong
TI Multifocal infection of mycobacterium other than tuberculosis mimicking a soft 
SO Orthopedics
LA English
DT Journal Article
AB Mycobacterium other than tuberculosis infections rarely develop in healthy 
   individuals, but direct inoculation such as contaminated acupuncture can cause 
   mycobacteriosis even in an immunocompetent host. A 56-year-old woman gradually 
   developed pain on the anterior aspect of the left knee and the distal thigh after 
   hiking without trauma. She received acupuncture for 3 consecutive days on the 
   bilateral knees at the suprapatellar and infrapopliteal areas. After acupuncture, 
   mild localized heat and painful swelling developed around the knees bilaterally. 
   Magnetic resonance imaging (MRI) demonstrated soft tissue masses with a lobulated 
   contour at the prefemoral fat between the suprapatellar pouch and the distal 
   femur and at the proximal tibia behind the knee joint capsule. Fibromatosis, 
   pigmented villonodular synovitis, and soft tissue sarcoma were considered. On 
   pathologic examination, multiple granulomas with lymphoplasmatic infiltration 
   were evident, and acid-fast bacteria staining revealed acid-fast bacilli. A 
   mycobacterial culture confirmed Mycobacterium other than tuberculosis infection, 
   and a polymerase chain reaction-fragment length polymorphism assay identified the 
   isolates as Mycobacterium abscessus. After treatment with appropriate 
   antibiotics, the patient had no evidence of disease and reported no pain during 
   activities of daily living. Acupuncture is growing in prominence in Europe and 
   the United States, and the number of reports on complications increases with its 
   widespread use. Although the risk to an individual patient is difficult to 
   determine, acupuncture may cause serious complications in patients with 
   coagulopathy, heart valve disease, and immune deficiency. In addition, direct 
   inoculation such as contaminated acupuncture can cause mycobacteriosis even in an 
   immunocompetent host.
C1 Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, South Korea.
NR 0
TC 0
SN 1938-236
EI 
J9 Orthopedics
PD DEC 8
PY 2011
VL 34
IS 12
BP e952
EP 5
DI 10.3928/01477447-20111021-31 
PG 1
WC Activities of Daily Living; Acupuncture Therapy; adverse effects; Anti-Bacterial Agents; therapeutic use; Diagnosis, Differential; Female; Humans; Immunocompetence; Knee Joint; microbiology; Magnetic Resonance Imaging; Middle Aged; Mycobacterium Infections, Nontuberculous; complications; Nontuberculous Mycobacteria; isolation & purification; Pain; etiology; Pain Management; Soft Tissue Neoplasms; diagnosis; Treatment Outcome
UT PubMed:22146217
PM 22146217
DA 2011-12-08
ER

PT J
AU Oh, B
   Kimble, B
   Costa, DS
   Davis, E
   McLean, A
   Orme, K
   Beith, J
AF Oh, B
   Kimble, B
   Costa, D S J
   Davis, E
   McLean, A
   Orme, K
   Beith, J
TI Acupuncture for treatment of arthralgia secondary to aromatase inhibitor therapy 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE COMPLEMENTARY MEDICINE; PAIN MANAGEMENT; PAIN RESEARCH; THERAPEUTICS
AB BACKGROUND: Aromatase inhibitors (AIs) are recommended as adjuvant hormone 
   treatment for postmenopausal women with early breast cancer. A substantial 
   proportion of women taking AIs experience joint pain and stiffness. Studies have 
   suggested that acupuncture may be effective in treating joint pain. OBJECTIVE: A 
   pilot study was conducted to evaluate the feasibility, safety and efficacy of 
   using acupuncture to treat AI-induced arthralgia. METHODS: A total of 32 patients 
   were randomised to receive either sham or real electroacupuncture (EA) twice 
   weekly for 6 weeks. Outcomes of joint pain, stiffness and physical function were 
   measured with the Western Ontario and McMaster Universities Osteoarthritis Index 
   (WOMAC), overall pain severity and interference with the BPI-SF and quality of 
   life (QOL) with the Functional Assessment of Cancer Therapy-General (FACT-G) 
   instrument. Hand strength was assessed by a grip test, and a serum marker of 
   inflammation (C reactive protein (CRP)) was also measured. All assessments were 
   performed at baseline, 6 weeks and 12 weeks, except for blood samples at baseline 
   and 6 weeks only. RESULTS: No serious adverse events were reported during or 
   after acupuncture treatments. There were no significant differences in outcome 
   measures. However, positive trends were observed in stiffness and physical 
   function at week 12 in favour of real EA. CONCLUSIONS: Findings suggest that 
   acupuncture is feasible and safe in patients with breast cancer with joint pain 
   caused by AI. A larger study with adequately powered to confirm these results and 
   detect clinically relevant effects is needed.
C1 Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD JUN 1
PY 2013
VL 31
IS 3
BP 264
EP 71
DI 10.1136/acupmed-2012-010309 
PG -193
WC Activities of Daily Living; Adult; Aromatase; metabolism; Aromatase Inhibitors; adverse effects; Arthralgia; etiology; Breast Neoplasms; drug therapy; Electroacupuncture; Female; Humans; Middle Aged; Pilot Projects; Quality of Life; Range of Motion, Articular; Severity of Illness Index
UT PubMed:23722951
PM 23722951
DA 2013-06-01
ER

PT J
AU Abbasi, J
AF Abbasi, Jennifer
TI Can Acupuncture Keep Women on Their Breast Cancer Drugs?
SO JAMA
LA English
DT Journal Article
NR 0
TC 0
SN 1538-359
EI 
J9 JAMA
PD AUG 10
PY 2018
VL 320
IS 8
BP 744
EP 746
DI 10.1001/jama.2018.11068 
PG 2
WC Acupuncture Therapy; Aromatase Inhibitors; adverse effects; Breast Neoplasms; drug therapy; Female; Humans; Medication Adherence; Pain; chemically induced; Pain Management; methods
UT PubMed:30090939
PM 30090939
DA 2018-08-10
ER

PT J
AU Arif, F
   Haroon, SF
   Balagamwala, MA
AF Arif, Fizzah
   Haroon, Syeda Fizzah
   Balagamwala, Marium Aon
TI Implementation of Acupuncture Therapy in the Care of Patients with Breast Cancer.
SO Journal of acupuncture and meridian studies
LA English
DT Letter
C1 Dow Medical College, Dow University of Health and Sciences, Karachi, Pakistan. 
   Dow Medical College, Dow University of Health and Sciences, Karachi, Pakistan.
   Dow Medical College, Dow University of Health and Sciences, Karachi, Pakistan.
EM aarif.fizzah@gmail.com
NR 0
TC 0
SN 2093-815
EI 
J9 J Acupunct Meridian Stud
PD JUL 18
PY 2017
VL 10
IS 3
BP 155
EP 156
DI 10.1016/j.jams.2017.02.001 
PG 1
WC Acupuncture Therapy; Antineoplastic Agents; adverse effects; Breast Neoplasms; drug therapy; Female; Humans; Nausea; etiology; Pain, Postoperative; therapy; Quality of Life; Vomiting; etiology
UT PubMed:28712473
PM 28712473
DA 2017-07-18
ER

PT J
AU Ang, JY
   Bhojwani, K
   Chan, HK
   Chan, AC
AF Ang, Ju-Ying
   Bhojwani, Kavita
   Chan, Huan-Keat
   Chan, Ai-Chen
TI A Malaysian retrospective study of acupuncture-assisted anesthesia in breast lump 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE acupuncture; anesthesia; electroacupuncture, breast lump excision, retrospective study
AB INTRODUCTION: The objective of this retrospective study was to evaluate the 
   effectiveness and safety of acupuncture-assisted anesthesia (AAA) in breast lump 
   excision. METHODS: The medical records of all patients who underwent breast lump 
   excision under AAA in combination with electrical stimulation at traditional 
   acupuncture points in 2016 were examined. All of them (n = 17) received 
   electrostimulation (2-4 Hz) using single needles inserted at bilateral LI4 and 
   PC6. They also underwent insertion of four acupuncture needles at the lump site, 
   which were electrically stimulated at 30 Hz frequency. RESULTS: All surgical 
   procedures were successful with minimal use of analgesics and local anesthetic. 
   The median pain score reported was 1/10 (interquartile range (IQR) = 2/10) at the 
   first hour, and slightly increased to 2/10 (IQR = 2/10) between 24 and 48 h of 
   the surgery. No major postoperative adverse events were documented, except for 
   drowsiness in one case. CONCLUSION: AAA was found to be generally safe and 
   effective for anaesthesia and analgesia in breast lump excision. However, a 
   large-scale randomized controlled study is required to verify the findings.
C1 Clinical Research Centre, Hospital Raja Permaisuri Bainun, Ministry of Health, Malaysia.
   Department of Anaesthesiology and Intensive Care, Hospital Raja Permaisuri Bainun, Ministry of Health, Malaysia.
   Clinical Research Centre, Hospital Sultanah Bahiyah, Ministry of Health, Malaysia.
   Department of Surgery, Hospital Raja Permaisuri Bainun, Ministry of Health, Malaysia.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD JUN 17
PY 2020
VL 39
IS 1
BP 64
EP 68
DI 10.1177/0964528420920307 
PG 4
WC Acupuncture Analgesia; Acupuncture Points; Adult; Aged; Aged, 80 and over; Breast Neoplasms; surgery; Electroacupuncture; Female; Humans; Malaysia; Middle Aged; Retrospective Studies
UT PubMed:32539426
PM 32539426
DA 2020-06-17
ER

PT J
AU Chang, XU
   Na, LI
   Xiaoling, WU
   Xingye, D
   Zhiwen, Y
   Qianhui, S
   Tianyu, S
   Yemao, C
   Dandan, P
   Kai, C
AF Chang, X U
   Na, L I
   Xiaoling, W U
   Xingye, Dai
   Zhiwen, Yang
   Qianhui, Sun
   Tianyu, Shi
   Yemao, Chai
   Dandan, Pang
   Kai, Cheng
TI Effect of electroacupuncture on inflammatory signal expression in local tissues 
SO Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
LA English
DT Journal Article
DE NLR family, pyrin domain-containing 3 protein; chronic pelvic pain syndrome; cytokines; electroacupuncture; inflammatory; receptors, purinergic P2X7; signal transduction
AB OBJECTIVES: To study the expression of inflammatory signal in local prostate 
   tissue of chronic pelvic pain syndrome (CPPS) rats by electroacupuncture (EA) of 
   Guanyuan (CV4), Zhongji (CV3), Huiyang (BL35) and Sanyinjiao (SP6), and to 
   explore the possible mechanism of anti-inflammatory and analgesic effects of EA. 
   METHODS：A total of 36 Sprague-Dawley male rats were randomly divided into three 
   groups: control, model and EA (n=12 rats/group). The CPPS model was made by 
   injection of CFA into ventral lobes of the prostate (0.1 mL). Electric 
   acupuncture apparatus was applied to stimulate Guanyuan (CV4), Zhongji (CV3), 
   bilateral Huiyang (BL35) and Sanyinjiao (SP6) acupoints in EA group. The general 
   condition of rats was observed and the prostate index (PI) was calculated. The 
   thermal pain threshold was collected after each therapeutic course. 
   Histopathological changes of the prostate tissue were examined by 
   hematoxylin-eosin staining method. The expression levels of tumor necrosis factor 
   α (TNF-α), interleukin-1β (IL-1β) and prostaglandin E2 (PGE2) in prostatic 
   homogenates were measured by enzyme linked immunosorbent assay (ELISA). Moreover, 
   the expression levels of purinergic 2X7 receptor (P2X7R), NOD-like receptor pyrin 
   domain-containing 3 (NLRP3), caspase-1 and interleukin-18 (IL-18) mRNA were 
   quantified by quantitative real-time polymerase chain reaction. RESULTS: Compared 
   with control group, the PI of rats increased, and the thermal pain threshold 
   decreased significantly in model group. The morphological structure of prostate 
   tissues of rats in model group was severely damaged with a large number of 
   inflammatory cells infiltration. Additionally, the levels of TNF-α, IL-1β and 
   PGE2 were higher, and the expressions of P2X7R, NLRP3, caspase-1 and IL-18 mRNA 
   were higher than those in control group. After EA treatment, the PI was 
   significantly decreased, the thermal pain threshold was significantly increased, 
   and the tissue damage was significantly improved. The expressions of inflammatory 
   cytokines were lower in EA group, and expression of P2X7R/NLRP3 pathway was 
   down-regulated. CONCLUSION: The effect of EA at Guanyuan (CV4), Zhongji (CV3), 
   Huiyang (BL35) and Sanyinjiao (SP6) can improve inflammation and pain symptoms of 
   CPPS rats induced by Complete Freund's adjuvant (CFA). This suggests that EA at 
   Guanyuan (CV4), Zhongji (CV3), Huiyang (BL35) and Sanyinjiao (SP6) can produce 
   anti-inflammatory analgesia effect by preventing the activation of P2X7R/NLRP3 
   signal pathway, inhibit the release of inflammatory cytokines in CPPS rats, which 
   may provide a putative novel target for the treatment of CPPS.
C1 Major in Acupuncture and Tuina, school of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
   Experimental science of acupuncture and moxibustion teaching and research section, school of Acupuncture and Tuina, Beijing University of Chinese Medicine,Beijing 100029, China.
   Major in Acupuncture and Tuina, school of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
   Major in Acupuncture and Tuina, school of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
   Major in Acupuncture and Tuina, school of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
   Major in Acupuncture and Tuina, school of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
   Major in Acupuncture and Tuina, school of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
   Complex laboratory, school of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
   Academy of Chinese Medical Sciences, Beijing 100700, China.
   Meridians and acupoints teaching and research section, school of Acupuncture and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
NR 0
TC 0
SN 2589-451
EI 0255-292
J9 J Tradit Chin Med
PD NOV 16
PY 2022
VL 42
IS 6
BP 965
EP 971
DI 10.19852/j.cnki.jtcm.20220928.003 
PG 6
WC Rats; Male; Animals; Electroacupuncture; Interleukin-18; NLR Family, Pyrin Domain-Containing 3 Protein; genetics; Pyrin Domain; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; genetics; Dinoprostone; Pelvic Pain; genetics; Chronic Pain; Freund's Adjuvant; Signal Transduction; Cytokines; RNA, Messenger; Caspases
UT PubMed:36378055
PM 36378055
DA 2022-11-16
ER

PT J
AU Yan, Z
   Huang, W
   Li, S
   Zhang, W
   Hu, Y
   Liu, Chunjing
AF Yan, Zhongkai
   Huang, Wei
   Li, Suli
   Zhang, Weijing
   Hu, Yuqing
   Liu Chunjing
TI [Impact of huolong moxibustion on TNF-α and pain degree in the patients of 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB OBJECTIVE: To discuss the impact of huolong moxibustion on pain degree in the 
   patients of discogenic low back pain and the effect mechanism. METHODS: 
   Sixty-five patients were randomized into an observation group (33 cases) and a 
   control group (32 cases). In the observation group, huolong moxibustion was 
   applied along the distribution of the Governor Vessel, once a day. In the control 
   group, the routine traction combined with massage therapy was adopted, once a 
   day. In the two groups, the treatment was given 6 times a week, at interval of 1 
   day. In 3 weeks of treatment, pain score and serum tumor necrosis factor α 
   (TNF-α) level were compared with those before treatment in the two groups. 
   RESULTS: Compared with those before treatment, pain score and TNF-α level were 
   reduced significantly after treatment in the two groups (both P < 0.05). The 
   results in the observation group were lower than those in the control group (pain 
   score: 1.95 ± 0.61 vs 2.11 ± 0.61; TNF-α: (1.33 ± 0.30) nmol/L vs (1.55 ± 0.48) 
   nmol/L, (both P < 0.05). CONCLUSION: Huolong moxibustion significantly alleviates 
   pain in the patients of discogenic low back pain and its effect mechanism is 
   possibly relevant with TNF-α reducing.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAR 5
PY 2016
VL 35
IS 11
BP 1121
EP 3
DI 
PG -1118
WC Adult; Female; Humans; Low Back Pain; metabolism; Male; Massage; Middle Aged; Moxibustion; Pain Measurement; Traction; Tumor Necrosis Factor-alpha; metabolism; Young Adult
UT PubMed:26939323
PM 26939323
DA 2016-03-05
ER

PT J
AU Kim, TH
   Kang, JW
   Lee, TH
AF Kim, Tae-Hun
   Kang, Jung Won
   Lee, Tae Hee
TI Therapeutic options for aromatase inhibitor-associated arthralgia in breast 
SO Maturitas
LA English
DT Journal Article
DE Acupuncture; Aromatase inhibitor-associated arthralgia; Network meta-analysis; Overview of systematic reviews; Scoping study
AB Aromatase inhibitor-associated arthralgia (AIA) is a common problem in breast 
   cancer survivors and is associated with noncompliance with aromatase inhibitor 
   therapy. The aim of this research was to assess the current evidence for the 
   various therapeutic options available for AIA. We searched the PubMed, EMBASE, 
   Cochrane Database of Systematic Reviews, and Database of Abstracts of Reviews of 
   Effects for systematic reviews of trials investigating treatments for AIA to June 
   2018. Eligible systematic reviews were subjected to evidence mapping and the 
   randomized controlled trials included in the systematic reviews were 
   hand-searched for a network meta-analysis. Six systematic reviews were included 
   in the evidence mapping. Acupuncture was the most common treatment modality 
   studied (four randomized controlled trials), and pharmacological interventions, 
   aerobic exercise, Nordic walking, omega-3 fatty acids, and vitamin D were 
   assessed less frequently. In view of the limitations in the overall confidence 
   level for each review, the evidence for acupuncture as an effective treatment for 
   AIA was considered low. Second, data from 6 randomized controlled trials were 
   included in the network meta-analysis. When compared with a waiting list control, 
   acupuncture (mean difference [MD] -2.00, 95% confidence interval [CI] -3.16, 
   -0.84), aerobic exercise (MD -0.80, 95% CI -1.33, -0.016), and omega-3 fatty 
   acids (MD -2.10, 95% CI -3.23, -0.97) significantly improved pain severity 
   scores. Network meta-analysis of adverse events was not possible because of poor 
   reporting. Acupuncture is presently the most widely investigated intervention but 
   is recommended for AIA with low overall confidence based on the current evidence.
C1 Korean Medicine Clinical Trial Center, Korean Medicine Hospital, Kyung Hee University, (#)23 kyungheedae-ro, Dondaemun-gu, Seoul, 130-872, South Korea.
   Department of Acupuncture & Moxibustion, College of Korean Medicine, Kyung Hee University, (#)23 kyungheedae-ro, Dondaemun-gu, Seoul, 130-872, South Korea.
   Department of Formulae Pharmacology, College of Korean Medicine, Gachon University, Seong-Nam, South Korea.
EM taehunkim@khu.ac.kr
NR 0
TC 0
SN 1873-411
EI 
J9 Maturitas
PD NOV 13
PY 2018
VL 118
IS 
BP 29
EP 37
DI 10.1016/j.maturitas.2018.09.005 
PG 8
WC Acupuncture Therapy; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Cancer Survivors; Evidence-Based Medicine; Exercise; Fatty Acids, Omega-3; therapeutic use; Female; Humans; Pain Measurement; Review Literature as Topic; Vitamin D; therapeutic use
UT PubMed:30415752
PM 30415752
DA 2018-11-13
ER

PT J
AU Li, H
   Schlaeger, JM
   Patil, CL
   Danciu, O
   Chen, Z
   Lif, N
   Gao, S
   Doorenbos, AZ
AF Li, Hongjin
   Schlaeger, Judith M
   Patil, Crystal L
   Danciu, Oana
   Chen, Zhengjia
   Lif, Natalie
   Gao, Shuang
   Doorenbos, Ardith Z
TI Feasibility of implementing acupuncture in medically underserved breast cancer 
SO Contemporary clinical trials
LA English
DT Journal Article
DE Acupuncture; Barriers; Breast cancer; Facilitators; Multiple symptoms; Underserved
AB Nearly 94% of breast cancer survivors experience one or more symptoms or side 
   effects during or after endocrine therapy. Joint pain, hot flashes, sleep 
   disturbance, fatigue, depression, and anxiety are the most common concurrent 
   symptoms, some of which can persist for 5 to 10 years. Acupuncture is a holistic 
   modality that addresses multiple symptoms and side effects in a single therapy. 
   Acupuncture has not yet been investigated for its effectiveness in treating the 
   multiple symptoms experienced by breast cancer survivors receiving endocrine 
   therapy. Medically underserved breast cancer survivors typically have limited 
   access to acupuncture. The barriers limiting access to acupuncture need to be 
   removed to enable equal access to breast cancer survivors for this evidence-based 
   treatment. Thus, we developed a randomized controlled trial with a 5-week 
   acupuncture intervention versus usual care for medically underserved breast 
   cancer survivors. Mixed methods (semi-structured interviews, surveys, study 
   notes) will be used to obtain in-depth understanding of barriers and facilitators 
   for eventual implementation of the acupuncture intervention. This study will 
   facilitate the widespread implementation, dissemination, and sustained 
   utilization of acupuncture for symptom management among medically underserved 
   breast cancer survivors receiving endocrine therapy.
C1 University of Illinois, Chicago College of Nursing, Department of Human Development Nursing Science, 845 S. Damen Avenue (M/C 802), Chicago, IL 60612,USA
   University of Illinois Cancer Center, 818 South Wolcott Ave, Chicago, IL60612, USA. 
   University of Illinois, Chicago College of Nursing, Department of Human Development Nursing Science, 845 S. Damen Avenue (M/C 802), Chicago, IL 60612,USA.
   University of Illinois, Chicago College of Nursing, Department of Human Development Nursing Science, 845 S. Damen Avenue (M/C 802), Chicago, IL 60612,USA.
   University of Illinois, Chicago College of Medicine, Department of Hematology/Oncology, 820 S. Wood Street Suite 172 CSN (M/C 712), Chicago, IL60612, USA.
   University of Illinois Cancer Center, 818 South Wolcott Ave, Chicago, IL 60612, USA.
   University of Illinois, Chicago College of Nursing, Department of Human Development Nursing Science, 845 S. Damen Avenue (M/C 802), Chicago, IL 60612,USA.
   University of Illinois, Chicago College of Medicine, 1853 W Polk St, Chicago, IL 60612, USA.
   University of Illinois Cancer Center, 818 South Wolcott Ave, Chicago, IL 60612, USA
   University of Illinois, Chicago College of Nursing, Department ofBiobehavioral Nursing Science, 845 S. Damen Avenue (M/C 802), Chicago, IL 60612,USA.
EM hongjin@uic.edu
NR 0
TC 0
SN 1559-203
EI 1551-714
J9 Contemp Clin Trials
PD NOV 17
PY 2023
VL 136
IS 
BP 107387
EP 107387
DI 10.1016/j.cct.2023.107387 
PG 0
WC Humans; Female; Breast Neoplasms; drug therapy; Cancer Survivors; Feasibility Studies; Medically Underserved Area; Treatment Outcome; Acupuncture Therapy; Randomized Controlled Trials as Topic
UT PubMed:37972754
PM 37972754
DA 2023-11-17
ER

PT J
AU Saraswati, W
   Wardani, R
   Suhatno, S
   Hartono, P
   Imandiri, A
AF Saraswati, Wita
   Wardani, Ratih
   Suhatno, Suhatno
   Hartono, Pudjo
   Imandiri, Ario
TI The Effect of Electroacupuncture Therapy on Pain, Plasma β-Endorphin, and Quality 
SO Journal of acupuncture and meridian studies
LA English
DT Journal Article
DE Cervical cancer; Electroacupuncture; Quality of life; VAS; β-endorphin
AB BACKGROUND: Pain is a major complaint in cancer patients and a global problem 
   that requires medical attention, including pain in cervical cancer. Although 
   pharmacotherapy has been used for the treatment of cancer pain, there are still 
   around 40% cannot be treated only with pharmacotherapy. OBJECTIVES: To determine 
   the effects of electroacupuncture (EA) on pain in stage III cervical cancer 
   patients. METHODS: Twenty-eight stage III cervical cancer patients were divided 
   into two groups (14 treatments and 14 controls) with randomized control trial 
   design. The treatment group received EA with a frequency of 2/20-25 Hz at points 
   of ST36, SP6, LI4 and LR3 for 30 minutes, while the control group did not receive 
   EA. Both groups were given paracetamol and codeine at the same dose. Assessment 
   was carried out by measuring pain scale (VAS), plasma β-endorphin levels, and 
   quality of life/QoL (EORTC QLQ-C30) before and after therapy. RESULTS: The 
   average reduction in VAS in the treatment group (2.71 ± 1.14) compared to the 
   control group (0.71 ± 1.33; p < 0.001), average increase in plasma β-endorphin 
   levels in the treatment group (88.57 ± 52.46 pg/ml) compared to the control group 
   (12.86 ± 56.76 pg/ml; p = 0.001), and in QoL, there were significant differences 
   in symptom improvement between the treatment and control groups in the domain of 
   fatigue, pain, insomnia and overall QoL (p < 0.05). CONCLUSION: Medical therapy 
   combined with EA decreased pain scale, increased plasma β-endorphin levels, and 
   improved the QoL for stage III cervical cancer patients.
C1 Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
   Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
   Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
   Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
   Department of Traditional Healer, Faculty of Vocations, Universitas Airlangga, Surabaya, Indonesia.
NR 0
TC 0
SN 2093-815
EI 
J9 J Acupunct Meridian Stud
PD FEB 28
PY 2021
VL 14
IS 1
BP 4
EP 12
DI 10.51507/j.jams.2021.14.1.4 
PG 8
WC Electroacupuncture; Female; Humans; Pain; Quality of Life; Uterine Cervical Neoplasms; therapy; beta-Endorphin
UT PubMed:35770596
PM 35770596
DA 2021-02-28
ER

PT J
AU Zhu, S
   Song, Q
   Liu, C
   Yang, D
AF Zhu, Shizhuang
   Song, Qingyu
   Liu, Changyue
   Yang, Dianhui
TI Acupoint application for postherpetic neuralgia with qi stagnation and blood 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE 5-hydroxytryptamine (5-HT); acupoint application; acupoint injection; interleukin-6 (IL-6); monocyte chemoattractant protein-1 (MCP-1); postherpetic neuralgia (PHN); swelling-reducing and pain-relieving patches; tumor necrosis factor-alpha (TNF-α)
AB OBJECTIVES: To observe the clinical efficacy of acupoint application in treating 
   postherpetic neuralgia(PHN) with qi stagnation and blood stasis, and its effects 
   on serum inflammatory factors and 5-hydroxytryptamine (5-HT) in patients. 
   METHODS: A total of 136 PHN patients were randomly divided into an observation 
   group (68 cases, 6 case dropped out) and a control group (68 cases, 5 cases 
   dropped out). In the observation group, the combination of swelling-reducing and 
   pain-relieving patches and acupoint application with herbal powder was used at 
   bilateral Sanyinjiao (SP 6), Shenque (CV 8) and ashi points. Sanyinjiao (SP 6) 
   was applied for 30 min per session, once every 7 days; and Shenque (CV 8) and 
   ashi points were applied for 6-8 h per session, once every 1 day. In the control 
   group, mecobalamin injection was administered at Jiaji (EX-B 2) corresponding to 
   the neural segments governing the painful area, 1 mL per injection, once a day. 
   Each treatment course consisted of 7 days, 4 treatment courses were required in 
   both groups. The visual analog scale (VAS) score for pain, 36-item short form 
   health survey (SF-36) score, traditional Chinese medicine syndrome score, and the 
   serum levels of inflammatory factors (monocyte chemoattractant protein-1 [MCP-1], 
   interleukin-6 [IL-6], tumor necrosis factor-alpha [TNF-α]) and 5-HT were compared 
   in the patients of the two groups before and after treatment, and the clinical 
   efficacy was evaluated. RESULTS: After treatment, the VAS scores, traditional 
   Chinese medicine syndrome scores, serum MCP-1, IL-6, TNF-α, and 5-HT levels were 
   decreased compared with those before treatment in both groups (P<0.05), and the 
   results in the observation group were lower than those in the control group 
   (P<0.05). The SF-36 scores were increased compared with those before treatment in 
   the two groups (P<0.05), and the result in the observation group was higher than 
   that in the control group (P<0.05). The total effective rate of the observation 
   group was 74.2% (46/62), which was higher than 52.4% (33/63, P<0.05) of the 
   control group. CONCLUSIONS: The combination of swelling-reducing and 
   pain-relieving patches and acupoint application with herbal powder has shown 
   better efficacy in treating PHN with qi stagnation and blood stasis, which can 
   significantly alleviate patients symptoms, improve their quality of life, and 
   reduce serum levels of MCP-1, IL-6, TNF-α, and 5-HT.
C1 School of Acupuncture-Moxibustion and Tuina,Shandong University of TCM, Jinan 250355, China. 1337199684@qq.com.
   School of Acupuncture-Moxibustion and Tuina,Shandong University of TCM, Jinan 250355, China.
   School of Acupuncture-Moxibustion and Tuina,Shandong University of TCM, Jinan 250355, China.
   School of Acupuncture-Moxibustion and Tuina,Shandong University of TCM, Jinan 250355, China. jnyangdh@126.com.
   Department of Acupuncture and Moxibustion, Affiliated Hospital of Shandong 
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD FEB 20
PY 2024
VL 44
IS 2
BP 158
EP 162
DI 10.13703/j.0255-2930.20230628-k0004 
PG 4
WC Humans; Neuralgia, Postherpetic; drug therapy; Qi; Serotonin; Acupuncture Points; Quality of Life; Interleukin-6; Tumor Necrosis Factor-alpha; Powders
UT PubMed:38373761
PM 38373761
DA 2024-02-20
ER

PT J
AU Zhang, RY
   Zhu, BF
   Zhao, JG
   Zhao, L
   Wang, LK
AF Zhang, R Y
   Zhu, B F
   Zhao, J G
   Zhao, L
   Wang, L K
TI Electroacupuncture Stimulation Alleviates Inflammatory Pain in Male Rats by 
SO Physiological research
LA English
DT Journal Article
AB In the present study, we focused on whether the analgesic effect of 
   Electroacupuncture (EA) is related to the regulation of oxidative stress. We 
   established a chronic inflammatory pain model in male rats by a single injection 
   of complete Freund's adjuvant (CFA) and then treated the animals with daily EA 
   stimulation at the site of "zusanli". The analgesic effect of EA was evaluated by 
   measuring the paw withdrawal threshold (PWT) when rats received mechanical and 
   thermal pain stimulation. The levels of inflammation-related molecules and 
   oxidative stress-related markers in the spinal cord were measured by western 
   blotting or ELISA kits. EA stimulation and antioxidants effectively increased the 
   PWT in CFA rats. Co-treatment of CFA rats with the ROS donor t-butyl 
   hydroperoxide (t-BOOH) further decreased the PWT and weakened the analgesic 
   effect of EA. EA treatment inhibited inflammation and oxidative stress, as shown 
   by decreased levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta 
   (IL-1beta), IL-6, and MDA and increased activity of SOD and catalase. Moreover, 
   EA reduced the expression of p-p38, p-ERK, and p-p65 and simultaneously 
   downregulated the expression of TRPV1 and TRPV4 in CFA rats. In an in vitro 
   study, direct stimulation with t-BOOH to the C6 cells increased the production of 
   TNF-alpha, IL-1beta, IL-6, activated p38, ERK, and p65 and up-regulated the 
   expression of TRPV1 and TRPV4, and these effects could be prevented by the ROS 
   scavenger PBN. Taken together, our data indicate that the inhibition of oxidative 
   stress and the generation of ROS contribute to the analgesic effect of EA in male 
   CFA rats.
C1 Department of Pain Management, Anhui Medical University, Hospital of Hefei, Hefei, People's Republic of China. wlk9560@163.com.
NR 0
TC 0
SN 1802-997
EI 0862-840
J9 Physiol Res
PD NOV 28
PY 2023
VL 72
IS 5
BP 657
EP 667
DI 10.33549/physiolres.934965 
PG 10
WC Rats; Male; Animals; TRPV Cation Channels; Electroacupuncture; Tumor Necrosis Factor-alpha; Interleukin-6; Reactive Oxygen Species; Rats, Sprague-Dawley; Chronic Pain; Inflammation; chemically induced; Analgesics; Oxidative Stress
UT PubMed:38015764
PM 38015764
DA 2023-11-28
ER

PT J
AU Du, JY
   Chen, F
   Jiang, B
   Fu, TF
   Fang, JQ
   Liang, Y
AF Du, Jun Ying
   Chen, Feng
   Jiang, Bin
   Fu, Tao Fang
   Fang, Jian Qiao
   Liang, Yi
TI [Bone-edge electroacupuncture relieves pain by regulating expression of GRK5, 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE G protein­coupled receptor kinase (GRK5); Bone­edge acupoint; Electroacupuncture analgesia; Locus coeruleus; Morphine tolerance; PKCα; β­arrestin 2
AB OBJECTIVE: To observe the effect of bone-edge electroacupuncture (EA) 
   intervention on mechanical pain threshold (PT) and expression of G 
   protein-coupled receptor kinase (GRK5), β-arrestin 2, total and phosphorylated 
   PKC alpha (p-PKCα) proteins in the locus coeruleus (LC) of rats with bone cancer 
   pain induced morphine tolerance, so as to reveal its partial central mechanisms 
   underlying pain relief. METHODS: Forty SD rats were randomly divided into 5 
   groups, namely sham bone cancer, bone cancer pain, morphine tolerance, bone-edge 
   EA, and sham EA (n＝ 8 rats in each group). The bone cancer with morphine 
   tolerance model was established by intramedullary injection of MRMT-1 cells into 
   the tibial cavity, and then intraperitoneal injection of morphine hydrochloride 
   injection. After successful establishment of morphine tolerance model, the 
   bone-edge EA (2 Hz/100 Hz，0.5－1.5 mA) was applied to bilateral "Zusanli" (ST36) 
   and "Kunlun" (BL60) for 30 min, once a day for 7 days, after inserting the 
   needle-tip to the tibial bone surface. The ipsilateral mechanical paw withdrawal 
   thresholds (PWTs) were detected dynamically. The expression levels of GRK5, 
   β-arrestin 2, PKCα and p-PKCα in the LC area were measured by Western blot. 
   RESULTS: The PWTs of bone cancer pain rats were decreased on day 10 after 
   inoculation of cancer cells (P<0.01). After i．p. of morphine for 11 days, no 
   analgesic effect and pain tolerance appeared (P>0.05). The PWTs were 
   significantly increased in the bone-edge EA intervention group (P<0.01), not in 
   the sham EA group (P>0.05). In comparison with the sham bone cancer group, the 
   expression of GRK5 protein in morphine tolerance group was significantly 
   decreased (P<0.01); compared with morphine tolerance group, the expression of 
   GRK5 protein in bone-edge EA group was increased(P<0.01). In comparison with the 
   sham bone cancer group, the expression of β-arrestin 2 and p-PKCα in bone cancer 
   group significantly increased (P<0.01). After the intervention, the increased 
   β-arrestin 2 and p-PKCα expressions were reversed in the bone-edge EA group 
   (P<0.01); compared with morphine tolerance group and sham EA group, the 
   expression of PKCα protein was decreased(P<0.01). CONCLUSION: Bone-edge EA can 
   effectively relieve morphine tolerance in bone cancer pain rats, which may be 
   related to its functions in up-regulating GRK5 protein and down-regulating 
   β-arrestin 2, PKCα and p-PKCα proteins in LC.　.
C1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou 310053,China.
   The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053
   The First Affiliated Hospital of Jiaxing College, Jiaxing314001, Zhejiang Province.
   The First Affiliated Hospital of Jiaxing College, Jiaxing 314001, Zhejiang Province.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou 310053,China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou 310053,China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou 310053,China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD MAR 8
PY 2020
VL 45
IS 2
BP 87
EP 92
DI 10.13702/j.1000-0607.1900036 
PG 5
WC Acupuncture Points; Animals; Bone Neoplasms; Cancer Pain; Electroacupuncture; G-Protein-Coupled Receptor Kinase 5; Locus Coeruleus; Morphine; Protein Kinase C-alpha; Rats; Rats, Sprague-Dawley; beta-Arrestin 2
UT PubMed:32144916
PM 32144916
DA 2020-03-08
ER

PT J
AU Mokaberinejad, R
   Rampisheh, Z
   Aliasl, J
   Akhtari, E
AF Mokaberinejad, Roshanak
   Rampisheh, Zahra
   Aliasl, Jale
   Akhtari, Elham
TI The comparison of fennel infusion plus dry cupping versus metformin in management 
SO Journal of obstetrics and gynaecology : the journal of the Institute of 
LA English
DT Journal Article
DE Fennel; PCOS; dry cupping; menstruation; metformin; oligomenorrhoea
AB Oligomenorrhoea treatment with hormone therapy and Metformin is not usually well 
   tolerated and is associated with a broad range of side effects. In Persian 
   medicine, the management of oligomenorrhoea can be done with fennel and dry 
   cupping. A clinical trial was conducted on 61 patients with oligomenorrhoea. The 
   patients randomly received treatment for 6 months in two groups: fennel infusion 
   plus dry cupping (Group A); versus treatment with Metformin (Group B). On the 
   days between the two periods, the patients' BMI, pain levels and side effects 
   were assessed. Thirty-one patients (mean age: 26.68) in Group A, and 30 patients 
   (mean age: 28.90) in Group B were enrolled. The mean numbers of days between the 
   two periods after 3 and 6 months in Group A was, respectively, 32.59 and 30.69, 
   versus 40.66 and 431.22 in Group B. The mean pain severity dropped significantly 
   in Group A. Fennel seed infusion plus a dry cupping uses a safe and effective 
   therapeutic intervention in the management of oligomenorrhoea. IMPACT STATEMENT 
   What is already known on this subject? Polycystic ovary syndrome (PCOS) is a 
   common endocrine disorder in women. Some common clinical manifestations of this 
   syndrome include menstrual disorders such as oligomenorrhoea and amenorrhoea. The 
   recommended therapeutic interventions include oral intervention, as well as 
   metformin, which are associated with an increased risk of vascular 
   thromboembolism, digestive complications such as nausea, and dizziness, and 
   vitamin B12 deficiency. Therefore, the use of complementary medicine in 
   controlling and treating PCOS is considered a valuable intervention in 
   conventional medicine. In Persian traditional medicine, medicinal fennel (with 
   the scientific name of Foeniculum Vulgare Mill) is commonly used in this regard. 
   The practice of dry cupping during the monthly period that ends with ovulation is 
   also recommended. What do the results of this study add? The present study 
   concludes that fennel seed infusion plus a dry cupping therapy is effective and 
   safe in reducing the days between two menstrual periods and manages 
   oligomenorrhoea. What are the implications of these findings for clinical 
   practice and/or further research? A clinical study is suggested for assessing the 
   effect of fennel seed infusion plus dry cupping on oligomenorrhoea, with a large 
   sample size and a longer follow up time.
C1 a Department of Traditional Medicine , School of Traditional Medicine Shahid Beheshti University of Medical Sciences , Iran.
   b Preventive Medicine and Public Health Research Center , Iran University of Medical Sciences , Tehran , Iran.
   c Community Medicine Department, School of Medicine , Iran University of Medical 
   d Traditional Medicine Clinical Trial Research Center , Shahed University , Tehran , Iran.
   e Research Institute for Islamic and Complementary Medicine, School of Iranian Traditional Medicine , Iran University of Medical Sciences , Tehran , Iran.
NR 0
TC 0
SN 1364-689
EI 
J9 J Obstet Gynaecol
PD MAR 12
PY 2019
VL 39
IS 5
BP 652
EP 658
DI 10.1080/01443615.2018.1541232 
PG 6
WC Acupuncture Therapy; Adult; Body Mass Index; Cupping Therapy; Dysmenorrhea; therapy; Female; Foeniculum; chemistry; Humans; Iran; Medicine, Traditional; Metformin; therapeutic use; Oligomenorrhea; therapy; Phytotherapy; Plant Extracts; administration & dosage; Polycystic Ovary Syndrome; complications; Seeds; chemistry
UT PubMed:30856025
PM 30856025
DA 2019-03-12
ER

PT J
AU Su, CF
AF Su, Ching-Feng
TI Home care with acupuncture increased the quality of life in a patient with 
SO Journal of integrative medicine
LA English
DT Journal Article
DE Acupuncture; Cancer; Case report; Hospice care; Neuropathic pain; Palliative care; Quality of life
AB A 66-year-old female patient was diagnosed with hepatocellular carcinoma 
   accompanied by neuropathic pain induced by a metastatic tumor that compromised 
   root and spinal canal. Although her pain was relieved following medical 
   treatment, breakthrough pain occurring 1-2 times a day was still distressing. 
   Neuropathic pain in her right lower limb caused discomfort and irritability and 
   decreased her quality of life. We had limited options to adjust her prescription 
   drug regime, due to the side effect of these drugs. Although acupuncture therapy 
   was only performed at her home once a week, the efficacy was outstanding. The 
   patient did not report any further instances of breakthrough pain, and she did 
   not require additional bolus morphine. She could comfortably live in her familiar 
   surroundings with her family and did not require any emergency room visits or 
   admission into the hospital during the last month of her life. She had excellent 
   quality of life in the terminal period of her life, and could even participate in 
   a family function during this time. The present case report suggests that 
   acupuncture may have a role in treating neuropathic pain induced by bone 
   metastasis in patients with advanced cancer across clinical and in-home settings.
C1 Department of Family Medicine, Pingtung Christian Hospital, Pingtung County 900, Taiwan, China. 
EM 04836@ptch.org.tw
NR 0
TC 0
SN 
EI 2095-496
J9 J Integr Med
PD APR 25
PY 2018
VL 16
IS 3
BP 208
EP 210
DI 10.1016/j.joim.2018.04.003 
PG 2
WC Acupuncture Therapy; Aged; Bone Neoplasms; complications; Carcinoma, Hepatocellular; pathology; Female; Home Care Services; Humans; Liver Neoplasms; pathology; Neoplasms; pathology; Neuralgia; etiology; Quality of Life
UT PubMed:29691187
PM 29691187
DA 2018-04-25
ER

PT J
AU Guan, QX
   Yang, H
   Liu, YM
   Li, Y
   Luo, YT
   Zou, SJ
AF Guan, Qing-Xia
   Yang, Han
   Liu, Yu-Meng
   Li, Ying
   Luo, Yu-Ting
   Zou, Shu-Jun
TI [Research progress on traditional Chinese medicine compounds combined with 
SO Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
LA chi
DT Review
DE combined therapy; external therapy; hyperplasia of mammary glands; research progress; traditional Chinese medicine compounds
AB Hyperplasia of mammary glands is a benign breast disease with disordered breast 
   structure. Nowadays, the incidence rate of breast hyperplasia in women is 
   increasing year by year, and the etiology is related to the imbalance of estrogen 
   and progesterone in the body. The symptoms include breast pain, breast nodules, 
   or nipple discharge, which can develop into breast cancer in the context of 
   psychological pressure. Therefore, it is timely and effectively necessary for 
   people to treat the symptoms. At present, traditional Chinese medicine(TCM) often 
   treats breast hyperplasia by oral drug, external application, acupuncture, 
   moxibustion, and massage, while western medicine often uses hormone therapy or 
   surgery. TCM can regulate hormone levels to treat breast hyperplasia. 
   Acupuncture, moxibustion, and other methods can stimulate acupoints to reduce 
   breast lumps. However, since TCM is easy to produce hepatorenal toxicity after 
   long-term use and simple external treatment is slow to take effect, rapid and 
   effective treatment is difficult to be achieved. Although western medicine can 
   inhibit the disease, it is easy to produce toxic and side effects if taken for a 
   long time. In addition, surgery can only remove the focus and the recurrence rate 
   is high. Some studies have found that the combination of oral and external use of 
   TCM compounds has a significant effect, with mild toxic and side effects, few 
   adverse reactions, and a low recurrence rate. Based on the relevant literature in 
   recent years, this article reviewed the combination of oral and external 
   treatment of TCM in the treatment of hyperplasia of mammary glands, discussed the 
   effectiveness, clinical evaluation indexes, and mechanism, and pointed out the 
   existing shortcomings to explore a comprehensive therapy worthy of clinical 
   application.
C1 School of Pharmacy, Heilongjiang University of Chinese Medicine Harbin 150006,China.
   School of Pharmacy, Heilongjiang University of Chinese Medicine Harbin 150006,China.
   School of Pharmacy, Heilongjiang University of Chinese Medicine Harbin 150006,China.
   School of Pharmacy, Heilongjiang University of Chinese Medicine Harbin 150006,China.
   School of Pharmacy, Heilongjiang University of Chinese Medicine Harbin 150006,China.
   School of Pharmacy, Heilongjiang University of Chinese Medicine Harbin 150006,China.
NR 0
TC 0
SN 
EI 1001-530
J9 Zhongguo Zhong Yao Za Zhi
PD JUN 29
PY 2023
VL 48
IS 11
BP 2856
EP 2867
DI 10.19540/j.cnki.cjcmm.20230315.601 
PG 11
WC Female; Humans; Mammary Glands, Human; Medicine, Chinese Traditional; Hyperplasia; Acupuncture Therapy; Breast Neoplasms; Drug-Related Side Effects and Adverse Reactions; Estrogens
UT PubMed:37381948
PM 37381948
DA 2023-06-29
ER

PT J
AU Kako, J
   Kajiwara, K
   Kobayashi, M
AF Kako, Jun
   Kajiwara, Kohei
   Kobayashi, Masamitsu
TI Could acupuncture be a treatment option for cancer patients with attitudinal 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Letter
C1 Division of Nursing Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.jkako-tky@umin.ac.jp.
   Japanese Red Cross Kyushu International College of Nursing, Munakata, Japan.
   Faculty of Nursing, National Defense Medical College, Tokorozawa, Japan.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD AUG 25
PY 2020
VL 29
IS 1
BP 3
EP 3
DI 10.1007/s00520-020-05712-6 
PG 0
WC Acupuncture Therapy; Cancer Pain; drug therapy; Humans; Neoplasms; complications; Pain; drug therapy; Pain Management
UT PubMed:32833095
PM 32833095
DA 2020-08-25
ER

PT J
AU Yan, L
   Sun, B
   Zhou, M
   Zhang, Y
   Gao, F
   Zhao, Q
   Wang, L
AF Yan, Li
   Sun, Bin
   Zhou, Meiyan
   Zhang, Yan
   Gao, Fei
   Zhao, Qianwen
   Wang, Liwei
TI [Effect of transcutaneous electrical acupoint stimulation on postoperative pain 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE breast cancer; inflammatory factors; modified radical mastectomy for breast cancer; postoperative acute pain; postoperative chronic pain; randomized controlled trial (RCT); transcutaneous electrical acupoint stimulation
AB OBJECTIVE: To observe the effect of transcutaneous electrical acupoint 
   stimulation (TEAS) on postoperative pain in patients undergoing modified radical 
   mastectomy for breast cancer. METHODS: A total of 140 female patients scheduled 
   for unilateral modified radical mastectomy for breast cancer undergoing general 
   anesthesia were randomized into a TEAS group (70 cases) and a sham TEAS group (70 
   cases, 2 cases dropped out). Patients in both groups received TEAS or sham TEAS 
   at bilateral Neiguan (PC6), Zusanli (ST36), and Danzhong (CV17), respectively, 
   from 30 min before anesthesia induction until the end of surgery, and on 1st, 
   2nd, and 3rd days after surgery for 30 min a time, once a day. On 1st, 2nd, and 
   3rd days after surgery, the pain visual analogue scale (VAS) score was observed; 
   on 3, 6, 12 months after surgery, the incidence rate of chronic pain was 
   observed; before surgery, and on 1st, 3rd, and 7th days after surgery, the serum 
   levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10 were 
   detected; the number of analgesia pump press, rescue analgesia, and the 
   occurrence of adverse reaction after surgery were recorded in the two groups. 
   RESULTS: In the TEAS group, the VAS scores on 1st and 2nd days after surgery, and 
   the incidence rates of chronic pain on 3 and 6 months after surgery were lower 
   than those in the sham TEAS group (P<0.05). On 1st, 3rd, and 7th days after 
   surgery, the serum levels of TNF-α, IL-6, and IL-10 were increased compared with 
   those before surgery in both groups (P<0.05, P<0.01); the above indexes in the 
   TEAS group were lower than those in the sham TEAS group (P<0.05). The number of 
   analgesia pump press and the incidence rate of rescue analgesia after surgery in 
   the TEAS group were lower than those in the sham TEAS group (P<0.05). There was 
   no statistically significant difference in the incidence of adverse reactions 
   after surgery between the two groups (P>0.05). CONCLUSION: TEAS can effectively 
   improve both the postoperative acute pain and chronic pain in patients undergoing 
   modified radical mastectomy for breast cancer, the mechanism may relate to 
   inhibiting the inflammatory reaction.
C1 Xuzhou Clinical School of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China
   Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou221009, Jiangsu Province.
   Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province.
   Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province.
   Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province.
   Department of Acupuncture-Moxibustion and Encephalopathy, Xuzhou Hospital of TCM.
   Xuzhou Clinical School of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China.
   Xuzhou Clinical School of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China
   Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou221009, Jiangsu Province.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD FEB 13
PY 2025
VL 45
IS 2
BP 162
EP 6
DI 10.13703/j.0255-2930.20240206-k0002 
PG -156
WC Humans; Female; Acupuncture Points; Pain, Postoperative; therapy; Middle Aged; Breast Neoplasms; surgery; Adult; Transcutaneous Electric Nerve Stimulation; Mastectomy, Modified Radical; adverse effects; Interleukin-6; blood; Tumor Necrosis Factor-alpha; blood; Interleukin-10; blood; Aged
UT PubMed:39943756
PM 39943756
DA 2025-02-13
ER

PT J
AU Eustachi, A
   Melchart, D
AF Eustachi, Axel
   Melchart, Dieter
TI [Complementary and Alternative Medicine in Oncology - What Makes Sense?].
SO Deutsche medizinische Wochenschrift (1946)
LA ger
DT Review
AB The basis of any complementary therapy should be the recommendation of a healthy 
   lifestyle (diet, nutrition, exercise, stress-reduction), and appropriate 
   self-help techniques (e. g. thermotherapy, herbal OTC-products) aimed at 
   releasing the patients' most debilitating symptoms. For therapy-resistant or 
   strong symptoms, more invasive interventions or medical treatments with an 
   acceptable evidence base can be used (e. g. acupuncture for cancer pain, herbal 
   prescriptions). The effects of any complementary intervention should be 
   controlled for a period of six weeks after its administration. Patients should be 
   advised not to use products or methods with possibly harmful side effects or 
   negative interactions with conventional medications.
NR 0
TC 0
SN 1439-441
EI 
J9 Dtsch Med Wochenschr
PD JUN 22
PY 2017
VL 142
IS 12
BP 882
EP 888
DI 10.1055/s-0042-121882 
PG 6
WC Acupuncture Therapy; adverse effects; Complementary Therapies; adverse effects; Evidence-Based Medicine; Exercise; Feeding Behavior; Humans; Life Style; Neoplasms; complications; Phytotherapy; adverse effects; Quality of Life; psychology; Risk Factors; Self Care; Stress, Psychological; complications
UT PubMed:28637073
PM 28637073
DA 2017-06-22
ER

PT J
AU Huang, KY
   Liang, S
   Hu, GY
   Zou, YY
   Lu, L
   Zhang, JB
AF Huang, Kai-yu
   Liang, Shuang
   Hu, Guang-yong
   Zou, Yang-yang
   Lu, Lu
   Zhang, Jian-bin
TI [From Biological Effects of Local Cutaneous Thermal Stimulation to Moxibustion 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Review
AB Moxibustion is one of the major external therapies of traditional Chinese 
   medicine (TCM) and exerts a definite favorable effect in the treatment of 
   patients with different problems. In the present paper, the authors reviewed 38 
   papers about somatic thermal intervention therapy published in recent 15 years 
   and analyzed its biological functions from local, distal, and whole body effects. 
   The local effects include 1) improving cutaneous inflammatory illnesses as 
   verruca, herpes simplex, Leishmania infection, cutaneous necrosis, wound 
   disunion, and promoting percutaneous absorption of some medicines, swelling pain; 
   2) reliving sports fatigue and muscular injury, eliminating inflammation and pain 
   reactions, probably by lowering local reactive oxygen species, superoxide 
   dismutase,catalase, glutathione, etc. levels, and strengthening the flexibility 
   of the knee-joint, and anterior and posterior cruciate ligaments; 3) increasing 
   blood perfusion of the regional arteriola, micrangium to eliminate accumulated 
   subcutaneous blood cells, inflammatory mediators and other metabolic products. 
   The distal effects contain 1) increase of the distal cutaneous blood flow and 
   suppression of the arterial stenosis; and 2) improvement of the visceral 
   functions including the heart (ischemia), liver, gastrointestinal blood flow and 
   smooth muscles, uterus smooth muscular tension, etc. The whole body effects 
   include raising immunoability against cancer, and reducing tumor blood flow to 
   damage the blood vessels in the tumor tissue, etc. In addition, the effects of 
   thermal stimulation are affected by the temperature, stimulating duration and the 
   stimulated positions. These research results may help us to comprehensively 
   understand the effects and mechanisms of moxibustion therapy in the treatment of 
   different clinical disorders.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD FEB 19
PY 2016
VL 40
IS 6
BP 504
EP 9
DI 
PG -495
WC Animals; Blood Circulation; Hot Temperature; Humans; Moxibustion; Skin; blood supply; Skin Temperature
UT PubMed:26887216
PM 26887216
DA 2016-02-19
ER

PT J
AU Cheon, S
   Lee, H
AF Cheon, Soyeon
   Lee, Hyangsook
TI Correspondence regarding Anshasi and Ahmad's "an assessment of methodological 
SO Complementary therapies in clinical practice
LA English
DT Letter
DE Acupoint injection; Acupuncture; Cancer; Pharmacopuncture
C1 Acupuncture and Meridian Science Research Centre, College of Korean Medicine, Kyung Hee University, Seoul, 02447, South Korea
   Department of Public Health,College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
   Acupuncture and Meridian Science Research Centre, College of Korean Medicine, Kyung Hee University, Seoul, 02447, South Korea. 
EM rc633@khu.ac.kr
NR 0
TC 0
SN 1873-694
EI 
J9 Complement Ther Clin Pract
PD NOV 7
PY 2018
VL 33
IS 
BP 138
EP 138
DI 10.1016/j.ctcp.2018.09.008 
PG 0
WC Acupuncture Therapy; Cancer Pain; Humans
UT PubMed:30396611
PM 30396611
DA 2018-11-07
ER

PT J
AU Zhong, Z
   Jin, K
   Qin, F
   Nie, R
AF Zhong, Zhinian
   Jin, Kang
   Qin, Fengling
   Nie, Rongrong
TI Huoxue Tongluo decoction combined with acupuncture in the treatment of lumbar 
SO Journal of back and musculoskeletal rehabilitation
LA English
DT Journal Article
DE Clinical disease; effectiveness; functional recovery
AB BACKGROUND: Lumbar disc herniation (LDH) is a common clinical disease of the 
   skeletal system, and its prevalence has been on a rise. OBJECTIVE: To evaluate 
   the efficacy of Huoxue Tongluo decoction plus acupuncture in the treatment of 
   lumbar disc herniation and its effectiveness in improving the functional recovery 
   of the patients' affected joints and mitigating their pain. METHODS: In this 
   prospective study, 110 patients with lumbar disc herniation enrolled in our 
   Hospital from June 2019 to June 2021 were collected and randomized to receive 
   either conventional treatment (control group) or Huoxue Tongluo Decoction plus 
   acupuncture (study group). RESULTS: Huoxue Tongluo Decoction plus acupuncture 
   resulted in more rapid mitigation of lower extremity symptoms and lumbar symptoms 
   versus conventional treatment (P< 0.05). Patients receiving traditional Chinese 
   medicine (TCM) showed milder inflammatory responses than those with conventional 
   medication, as evidenced by the lower serum concentrations of tumor necrosis 
   factor-α (TNF-α), interleukin (IL)-6, and high-sensitivity C-reactive protein 
   (hs-CRP) (P< 0.05). After treatment, the study group had higher Japanese 
   Orthopedic Association (JOA) scores and lower visual analogue scale (VAS) scores 
   than the control group (P< 0.05), suggesting that the combination of the herbal 
   decoction and acupuncture provided better functional recovery of the affected 
   joints and pain mitigation for the patients. Furthermore, the lower Pittsburgh 
   sleep quality index (PSQI) scores in patients in the study group indicated better 
   sleep quality of patients after TCM intervention than after conventional 
   treatment (P< 0.05). Huoxue Tongluo Decoction plus acupuncture was associated 
   with a significantly higher efficacy (94.55%) versus conventional treatment (80%) 
   (P< 0.05). CONCLUSIONS: Huoxue Tongluo Decoction combined with acupuncture 
   significantly offers a viable treatment alternative for lumbar disc herniation 
   with promising treatment outcomes, mitigates patients' limb pain, and improves 
   their lumbar function and sleep quality. Further trials are, however, required 
   prior to general application in clinical practice.
C1 Department of Rehabilitation Medicine, The Traditional Chinese Medicine Hospital of Qinzhou, Qinzhou, Guangxi, China.
   Department of Rehabilitation Medicine, The Traditional Chinese Medicine Hospital of Qinzhou, Qinzhou, Guangxi, China.
   Department of Rehabilitation Treatment, The Affiliated Hospital of Guilin Medical College, Guilin, Guangxi, China.
   Department of Rehabilitation Treatment, The Affiliated Hospital of Guilin Medical College, Guilin, Guangxi, China.
NR 0
TC 0
SN 1878-632
EI 
J9 J Back Musculoskelet Rehabil
PD SEP 4
PY 2023
VL 37
IS 2
BP 277
EP 283
DI 10.3233/BMR-220347 
PG 6
WC Humans; Acupuncture Therapy; Drugs, Chinese Herbal; therapeutic use; Intervertebral Disc Displacement; therapy; Lumbar Vertebrae; Pain; Prospective Studies; Treatment Outcome
UT PubMed:37661864
PM 37661864
DA 2023-09-04
ER

PT J
AU Nielsen, S
   Campbell, G
   Peacock, A
   Smith, K
   Bruno, R
   Hall, W
   Cohen, M
   Degenhardt, L
AF Nielsen, Suzanne
   Campbell, Gabrielle
   Peacock, Amy
   Smith, Kimberly
   Bruno, Raimondo
   Hall, Wayne
   Cohen, Milton
   Degenhardt, Louisa
TI Health service utilisation by people living with chronic non-cancer pain: 
SO Australian health review : a publication of the Australian Hospital Association
LA English
DT Journal Article
AB Objective The aims of the present study were to describe the use, and barriers to 
   the use, of non-medication pain therapies and to identify the demographic and 
   clinical correlates of different non-opioid pain treatments. Methods The study 
   was performed on a cohort (n=1514) of people prescribed pharmaceutical opioids 
   for chronic non-cancer pain (CNCP). Participants reported lifetime and past month 
   use of healthcare services, mental and physical health, pain characteristics, 
   current oral morphine equivalent daily doses and financial and access barriers to 
   healthcare services. Results Participants reported the use of non-opioid pain 
   treatments, both before and after commencing opioid therapy. Services accessed 
   most in the past month were complementary and alternative medicines (CAMs; 41%), 
   physiotherapy (16%) and medical and/or pain specialists (15%). Higher opioid dose 
   was associated with increased financial and access barriers to non-opioid 
   treatment. Multivariate analyses indicated being younger, female and having 
   private health insurance were the factors most commonly associated with accessing 
   non-opioid treatments. Conclusions Patients on long-term opioid therapy report 
   using multiple types of pain treatments. High rates of CAM use are concerning 
   given limited evidence of efficacy for some therapies and the low-income status 
   of most people with CNCP. Financial and insurance barriers highlight the 
   importance of considering how different types of treatments are paid for and 
   subsidised. What is known about the topic? Given concerns regarding long-term 
   efficacy, adverse side-effects and risk of misuse and dependence, prescribing 
   guidelines recommend caution in prescribing pharmaceutical opioids in cases of 
   CNCP, typically advising a multidisciplinary approach to treatment. There is a 
   range of evidence supporting different (non-drug) treatment approaches for CNCP 
   to reduce pain severity and increase functioning. However, little is known about 
   the non-opioid treatments used among those with CNCP and the demographic and 
   clinical characteristics that may be associated with the use of different types 
   of treatments. Understanding the use of non-drug therapy among people with CNCP 
   is crucial given the potential to improve pain control for these patients. What 
   does this paper add? The present study found that a wide range of non-opioid 
   treatments was accessed by the study sample, both before and after commencing 
   opioids, indicating that in this sample opioids were not the sole strategy used 
   for pain management. The most common treatment (other than opioids) was CAM, 
   reported by two-fifths of the sample. Having private health insurance was 
   associated with increased use of non-opioid treatments for pain, highlighting the 
   importance of considering how treatments are paid for and potential financial 
   barriers to effective treatments. What are the implications for practitioners? 
   Patients' beliefs and financial barriers may affect the uptake of different 
   treatments. Many patients may be using complementary and alternative approaches 
   with limited evidence to support their use, highlighting the need for clinicians 
   to discuss with patients the range of prescribed and non-prescribed treatments 
   they are accessing and to help them understand the benefits and risks of 
   treatments that have not been tested sufficiently, or have inconsistent evidence, 
   as to their efficacy in improving pain outcomes.
C1 National Drug and Alcohol Research Centre, UNSW, 22-32 King Street, Randwick, NSW 2031, Australia. Email:.
   National Drug and Alcohol Research Centre, UNSW, 22-32 King Street, Randwick, NSW 2031, Australia. Email:.
   School of Medicine, University of Tasmania, Private Bag 30, Hobart, Tas. 7001, Australia. Email:.
   National Drug and Alcohol Research Centre, UNSW, 22-32 King Street, Randwick, NSW 2031, Australia. Email:.
   National Drug and Alcohol Research Centre, UNSW, 22-32 King Street, Randwick, NSW 2031, Australia. Email:.
   Centre for Youth Substance Abuse Research, University of Queensland, Australia. Email.
   St Vincent's Clinical School, UNSW Medicine, Level 5 deLacy Building, St Vincent's Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia. Email.
   National Drug and Alcohol Research Centre, UNSW, 22-32 King Street, Randwick, NSW 2031, Australia. Email:.
NR 0
TC 0
SN 
EI 0156-578
J9 Aust Health Rev
PD NOV 26
PY 2015
VL 40
IS 5
BP 490
EP 499
DI 10.1071/AH15047 
PG 9
WC Acupuncture Therapy; Aged; Analgesics, Opioid; therapeutic use; Australia; Chronic Pain; therapy; Complementary Therapies; Drug Utilization; Female; Health Services; statistics & numerical data; Humans; Interviews as Topic; Male; Manipulation, Chiropractic; Middle Aged; Pain Management; methods; Pain Measurement; Physical Therapy Modalities; Practice Patterns, Physicians'; statistics & numerical data; Prospective Studies; Treatment Outcome
UT PubMed:26599263
PM 26599263
DA 2015-11-26
ER

PT J
AU Ying, Y
   Yang, G
   Li, X
   Wang, F
   Zhang, G
AF Ying, Yi
   Yang, Guodong
   Li, Xiaoyu
   Wang, Feifei
   Zhang, Guobing
TI Analgesic effects of electroacupuncture via the EphBs-p38 MAPK signaling pathway 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE EphBs; electroacupuncture; microglia; neuropathic pain; p38 mitogen-activated protein kinase
AB OBJECTIVE: To explore the analgesic effects of electroacupuncture (EA) and its 
   impact on the EphBs-p38 mitogen-activated protein kinase (MAPK) pathway and 
   microglia in a rat model of neuropathic pain (NP). METHODS: Following adaptive 
   training, 60 male Sprague Dawley (SD) rats were allocated to one of two 
   experiments. In experiment 1, rats received intrathecal SB203580 (p38 MAPK 
   inhibitor), intramuscular EphB1-Fc (EphBs inhibitor) or no injection before 
   undergoing chronic constrictive injury (CCI). In experiment 2, CCI model rats 
   received EA either alone or combined with either anisomycin (p38 MAPK agonist) or 
   EphrinB1-Fc (EphBs agonist) versus minimal acupuncture (MA) as a control 
   intervention. A sham surgery group was included in both experiments as a control 
   for CCI. All groups consisted of n = 6 rats (four in experiment 1 and six in 
   experiment 2). Behavioral hyperalgesia was examined and the spinal L5-6 region 
   was harvested and subjected to enzyme-linked immunosorbent assay to assess tumor 
   necrosis factor (TNF)-α and interleukin (IL)-1β levels. Western blotting and 
   immunofluorescence were used to assess protein expression of B-cell lymphoma 
   (Bcl)-2, Bcl-2 associated X-protein (BAX), EphB1, EphrinB1, p38 MAPK, 
   phosphorylated (p)-p38 MAPK and ionized calcium binding adaptor molecule (Iba)-1. 
   RESULTS: CCI induced behavioral hyperalgesia, as demonstrated by altered paw 
   withdrawal latency (PWL), paw withdrawal threshold (PWT) and cytokine levels, and 
   increased p38 MAPK phosphorylation and microglial activation. However, inhibitors 
   SB203580 and EphB1-Fc reversed these effects. Notably, EA showed similar 
   beneficial effects, but these were counteracted when combined with anisomycin and 
   EphrinB1-Fc. CONCLUSIONS: The analgesic effects of EA in this rat model of NP 
   appear to be linked to diminished p-p38 MAPK expression and subsequent microglial 
   deactivation. EA has a potential role as a complementary therapy for NP.
C1 Department of Traditional Chinese Medicine, XianJu People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju'sHospital, Hangzhou Medical College, Taizhou, China.
   Department of Orthopedics, XianJu People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju's Hospital, HangzhouMedical College, Taizhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third School of Clinical Medical(School of Rehabilitation Medicine), Zhejiang Chinese Medical University,Hangzhou, China.
   Department of Rehabilitation, XianJu People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital, Affiliated Xianju's Hospital, HangzhouMedical College, Taizhou, China.
   Department of Pharmacy, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, China.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD AUG 23
PY 2025
VL 43
IS 5
BP 278
EP 289
DI 10.1177/09645284251363987 
PG 11
WC Animals; Electroacupuncture; Rats, Sprague-Dawley; Male; Neuralgia; therapy; p38 Mitogen-Activated Protein Kinases; metabolism; Microglia; metabolism; Rats; Disease Models, Animal; Humans; MAP Kinase Signaling System; Interleukin-1beta; genetics; Signal Transduction; Tumor Necrosis Factor-alpha; genetics; Acupuncture Analgesia
UT PubMed:40847801
PM 40847801
DA 2025-08-23
ER

PT J
AU Herrera-Peco, I
   Moran, JM
   Santillan-Garcia, A
AF Herrera-Peco, Ivan
   Moran, Jose-María
   Santillan-Garcia, Azucena
TI Commentary on Transcutaneous Acupoint Interferential Current Stimulation for 
SO Integrative cancer therapies
LA English
DT Letter
C1 1 Universidad Alfonso X El Sabio, Madrid, Spain.
   2 Universidad Extremadura, Cáceres, Spain.
   3 Hospital Universitario de Burgos, Burgos, Spain.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD APR 25
PY 2019
VL 18
IS 
BP 1534735419845141
EP 1534735419845141
DI 10.1177/1534735419845141 
PG 1
WC Acupuncture Points; Analgesics, Opioid; Cancer Pain; Constipation; Humans; Neoplasms; Prospective Studies; Transcutaneous Electric Nerve Stimulation
UT PubMed:31014121
PM 31014121
DA 2019-04-25
ER

PT J
AU Du, J
   Fang, J
   Chen, Y
   Wu, S
   Liang, Y
   Fang, J
AF Du, Junying
   Fang, Junfan
   Chen, Yitian
   Wu, Saifei
   Liang, Yi
   Fang, Jianqiao
TI [Parametric optimization of electroacupuncture against bone-cancer pain in rats 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB OBJECTIVE: To observe the intervention of electroacupuncture (EA) with different 
   current frequencies and treatment frequencies on pain thresholt in rats with 
   bone-cancer pain, so as to optimize treatment parameters of EA against bone 
   cancer pain; and by measuring gene expression of opioid receptor and precursor in 
   different tissues to preliminarily explore the possible mechanism of EA against 
   bone cancer pain. METHODS: Ninety healthy female SD rats were randomly divided 
   into a control group, a model group, EA groups (6 subgroups according to 
   different frequencies) and a sham EA group, ten rats in each one. Rats in the 
   control group were injected with 10 µL of amicrobic phosphate buffer solution 
   (PBS) into tibial cavity; rats in the remaining groups were injected with Walker 
   256 cancer cells to establish model of bone-cancer pain. No treatment was given 
   to rats in the control group and model group; rats in the EA groups were treated 
   with EA at bilateral "Housanli" (ST 36) and "Genduan" with 3 different current 
   frequencies (2 Hz, 100 Hz and 2 Hz/100 Hz), once a day and once every other day, 
   30 min per treatment (1mA for 15 min, 2 mA for 15 min); rats in the sham EA group 
   were treated with identical acupoints as the EA group, but the acupoints were 
   needled subcutaneously and EA was connected with power off. All the treatment was 
   given for 14 days. Dynamic plantar aesthesiometer was applied to measure the paw 
   withdrawal thresholds (PWTs) of the affected side before the model establishment, 
   6d, 8d, 10d, 12d, 14d, 16d, 18d, and 20d after model establishment. The mRNA 
   expressions of µ-opioid receptor (MOR), κ-opioid receptor (KOR), δ-opioid 
   receptor (DOR), proopiomelanocortin (POMC) and prodynorphin (PDYN) in dorsal root 
   ganglion (DRG) and lumbar spinal cord dorsal horn (SCDH) of L4-L6 of the affected 
   side were detected by PCR method. RESULTS: There were no differences in PWTs 
   among all groups before model establishment (P>0. 05). Each time point after 
   model establishment, PWTs in model group were obviously lower than those in the 
   control group (all P<0. 01). Compared with the model group, PWTs in each EA 
   subgroup were all increased (all P<0.05), but the differences at different time 
   points were not significant among EA subgroups (P>0.05). The mRNA expressions of 
   MOR, KOR, POMC, and PDYN in L4-L6 DRG in the 2 Hz/100 Hz II group were 
   significantly higher than those in model group (P<0. 05, P<0. 01), while the mRNA 
   expressions of MOR, KOR, DOR, POMC and PDYN in SCDH were not different compared 
   with the model group (P>0. 05). CONCLUSION: EA treatment has obvious analgesic 
   effect on bone-cancer pain, however, its effect is not related with current 
   frequency and treating frequency. EA against bone-cancer pain may be related with 
   increasing the mRNA expression of some peripheral opioid receptors and precursor.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD APR 10
PY 2015
VL 35
IS 2
BP 161
EP 8
DI 
PG -153
WC Acupuncture Analgesia; instrumentation; Acupuncture Points; Animals; Bone Neoplasms; complications; Electroacupuncture; instrumentation; Enkephalins; metabolism; Female; Ganglia, Spinal; metabolism; Humans; Pain; etiology; Pain Management; instrumentation; Protein Precursors; metabolism; Rats; Rats, Sprague-Dawley; Receptors, Opioid; genetics
UT PubMed:25854026
PM 25854026
DA 2015-04-10
ER

PT J
AU Zhang, Y
   Li, A
   Xin, J
   Ren, K
   Berman, BM
   Lao, L
   Zhang, RX
AF Zhang, Y
   Li, A
   Xin, J
   Ren, K
   Berman, B M
   Lao, L
   Zhang, R-X
TI Electroacupuncture alleviates chemotherapy-induced pain through inhibiting 
SO European journal of pain (London, England)
LA English
DT Journal Article
AB BACKGROUND: Current medical treatments for chemotherapy-induced pain (CIP) are 
   either ineffective or have adverse side effects. Acupuncture may alleviate CIP, 
   but its effectiveness against this condition has not been studied. Paclitaxel 
   causes neuropathic pain in cancer patients. METHODS: We evaluated the effects of 
   electroacupuncture (EA) on paclitaxel-induced CIP in a rat model. Paclitaxel 
   (2 mg/kg) or vehicle was injected (i.p.) on alternate days of 0-6. The resulting 
   pain was treated with 10 Hz/2 mA/0.4 ms pulse EA for 30 min at the equivalent of 
   human acupoint GB30 (Huantiao) once every other day between days 14 and 26. For 
   sham control, EA needles were inserted into GB30 without stimulation. Von Frey 
   filaments with bending forces of 2-8 g and 15 g were used to assess mechanical 
   allodynia and hyperalgesia, respectively, on day 13 and once every other day 
   between 14-26 days and then for 2-3 weeks after EA treatment. RESULTS: Compared 
   to sham control, EA significantly alleviated paclitaxel-induced mechanical 
   allodynia and hyperalgesia, as shown by less frequent withdrawal responses to the 
   filaments. The alleviation of allodynia/hyperalgesia lasted up to 3 weeks after 
   the EA treatment. EA significantly inhibited phosphorylation of Ca(2+) 
   /calmodulin-dependent protein kinase II (CaMKII) in the spinal cord. KN-93, a 
   selective inhibitor of p-CaMKII, inhibited mechanical allodynia/hyperalgesia and 
   p-CaMKII. 5-HT1A receptor antagonist blocked EA inhibition of 
   allodynia/hyperalgesia and p-CaMKII. CONCLUSIONS: Electroacupuncture activates 
   5-HT 1A receptors in the spinal cord and inhibits p-CaMKII to alleviate both 
   allodynia and hyperalgesia. The data support acupuncture/EA as a complementary 
   therapy for CIP. SIGNIFICANCE: Electroacupuncture (EA) activates spinal 5-HT1A 
   receptors to inhibit p-CaMKII to alleviate paclitaxel-induced pain. 
   Acupuncture/EA may be used as a complementary therapy for CIP.
C1 Department of Physiology, Shanxi Medical University, Taiyuan, China.
   Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA.
   Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA.
   Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, USA.
   Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA.
   Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA.
   Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA.
NR 0
TC 0
SN 1532-214
EI 1090-380
J9 Eur J Pain
PD OCT 17
PY 2017
VL 22
IS 4
BP 679
EP 690
DI 10.1002/ejp.1132 
PG 11
WC Acupuncture Points; Animals; Antineoplastic Agents, Phytogenic; adverse effects; Calcium-Calmodulin-Dependent Protein Kinase Type 2; metabolism; Electroacupuncture; methods; Hyperalgesia; chemically induced; Male; Neuralgia; chemically induced; Paclitaxel; adverse effects; Phosphorylation; Rats; Rats, Sprague-Dawley; Spinal Cord; metabolism
UT PubMed:29034548
PM 29034548
DA 2017-10-17
ER

PT J
AU Wan, R
   Zheng, Q
   Zeng, X
   Luo, Y
   Sun, L
   Chen, S
   Luo, F
   Zhang, Y
   Zhu, Z
   Chen, X
   Zhao, Y
   Li, Y
AF Wan, Renhong
   Zheng, Qianhua
   Zeng, Xiaorui
   Luo, Yalan
   Sun, Luqiang
   Chen, Shuai
   Luo, Fangli
   Zhang, Yupeng
   Zhu, Ziyue
   Chen, Xinyun
   Zhao, Yuanyuan
   Li, Ying
TI Differential placebo effect of sham acupuncture for chronic pain: a network 
SO BMC complementary medicine and therapies
LA English
DT Journal Article
DE Chronic pain; Manual acupuncture; Meta-analysis; Placebo; Randomized controlled trial; Sham acupuncture
AB BACKGROUND: The clinical effects of acupuncture are often underestimated due to 
   the placebo effect of sham acupuncture. While multiple sham acupuncture methods 
   have been used in clinical practice, it is challenging to select the appropriate 
   sham acupuncture technique due to the lack of head-to-head trials. PURPOSE: The 
   purpose of this study was to compare the differential placebo effects of diverse 
   sham acupuncture interventions, providing evidence-based guidance for selecting 
   optimal placebo controls in clinical practice. METHOD: PubMed, Embase, the 
   Cochrane Central Register of Controlled Trials, and Web of Science were 
   systematically searched for randomized controlled trials comparing acupuncture 
   with sham acupuncture for the treatment of chronic non-cancer pain (from 
   inceptions to May 1, 2025). The primary outcome measure was pain variation, while 
   secondary outcome measures included adverse events and the assessment of 
   acupuncture blinding. Frequentist random-effect models were employed to perform 
   indirect treatment comparison meta-analysis, and Confidence in Network 
   Meta-Analysis (CINeMA) was utilized to evaluate the level of evidence. RESULTS: A 
   total of 45 randomized controlled trials (RCTs) were included, involving 7 sham 
   acupuncture methods and 8287 participants. Regarding pain variation, the 
   difference was noted between the waiting treatment group (mean difference 1.86 
   (95% confidence interval 1.36 to 2.35), SUCRA 97.4%; moderate confidence of 
   evidence) and manual acupuncture group was most pronounced, followed by the 
   difference between the acupoint and no penetration group (mean difference 1.14 
   (95% confidence interval 0.74 to 1.55), SUCRA 73.6%; low confidence of evidence) 
   and the nonacupoint and no penetration group (mean difference 1.00 (95% 
   confidence interval 0.35 to 1.65), SUCRA 64.8%; low confidence of evidence). 
   Additionally, the rate of adverse events was comparable among the aforementioned 
   sham acupuncture groups, and the blinding procedure was successfully implemented 
   in the trials. CONCLUSIONS: The placebo effect of sham acupuncture is 
   significant, among which the no penetration (acupoint or nonacupoint) groups 
   exhibited the lowest placebo effect. Nevertheless, further head-to-head trials 
   are warranted to obtain direct evidence. SYSTEMATIC REVIEW REGISTRATION: PROSPERO 
   no. CRD42024535012.
C1 Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Luzhou Longmatan TCM Hospital, Luzhou, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Jiangxi University of Traditional Chinese Medicine Affiliated Hospital, Jiangxi, China.
   Clinical Medical College of Integrated Traditional Chinese and Western Medicine, North Sichuan Medical College, Nanchong, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China. liying@cdutcm.edu.cn.
NR 0
TC 0
SN 2662-767
EI 
J9 BMC Complement Med Ther
PD SEP 2
PY 2025
VL 25
IS 1
BP 323
EP 323
DI 10.1186/s12906-025-05055-x 
PG 0
WC Humans; Acupuncture Therapy; methods; Chronic Pain; therapy; Placebo Effect; Placebos; Randomized Controlled Trials as Topic
UT PubMed:40890765
PM 40890765
DA 2025-09-02
ER

PT J
AU Fan, XN
   Zhang, X
   Wu, LZ
AF Fan, Xiao-nong
   Zhang, Xue
   Wu, Lian-zhong
TI [Dynamic observation on therapeutic features of thalamic pain by mind calming, 
SO Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
LA chi
DT Journal Article
AB OBJECTIVE: To observe therapeutic features of thalamic pain by mind Calming, 
   blood activating and pain relief acupuncture and Carbamazepine. METHODS: 
   Crossover trial design was adopted. Eleven patients with confirmed diagnosis of 
   thalamic pain were randomly assigned to two groups according to the minimal 
   unbalance index method, i.e., Group I (Six patients received acupuncture first 
   and then Western medicine.) and Group II (Five patients received Western medicine 
   first and then acupuncture). The therapeutic course for each group was ten days. 
   There was a ten-day elution phase between the two therapeutic methods. The total 
   therapeutic course was thirty days. Eleven patients were enrolled in the two 
   groups for statistical analysis. The therapeutic efficacy was assessed with 
   visual analogue scale (VAS) and the pain assessment scale of Anderson Cancer 
   Center in the USA (MD Pain Evaluation value) respectively. The VAS and MD values 
   of the two groups were recorded every day to get the dynamic curve. RESULTS: The 
   VAS and MD values obviously decreased in the two groups after treatment (P<0.05). 
   The pain curves of the two groups showed a declining trend during the treatment. 
   A gradual and stable descending process was shown in the acupuncture group. But a 
   greater decrease first appeared in the Western medicine group, then a 
   comparatively greater decrease occurred after one platform stage, showing 
   ladder-shaped curve. CONCLUSIONS: Cumulative potency may be the main analgesic 
   effects of acupuncture. Western medicine may possibly play a role by rapid 
   initiate effect.
C1 The Third Grade Dose-Effect Relationship of Acupuncture Lab, Key Research Room of Acupuncture at Cerebropathy, State Administration of Traditional ChineseMedicine, The Key Laboratory of Acupuncture in Tianjin, Tianjin 300193.fanxiaonong@163.com
NR 0
TC 0
SN 
EI 1003-537
J9 Zhongguo Zhong Xi Yi Jie He Za Zhi
PD AUG 10
PY 2011
VL 31
IS 6
BP 741
EP 4
DI 
PG -737
WC Acupuncture Analgesia; methods; Aged; Carbamazepine; therapeutic use; Cross-Over Studies; Female; Headache; therapy; Humans; Male; Middle Aged; Pain Management; Pain Measurement; Thalamic Diseases; therapy; Treatment Outcome
UT PubMed:21823414
PM 21823414
DA 2011-08-10
ER

PT J
AU Wang, L
   Li, T
   Cao, WX
   Zhao, JY
   Xu, XH
   Chai, JP
   Zhang, JX
   Liu, J
   Wang, FC
AF Wang, Lin
   Li, Tie
   Cao, Wen-Xuan
   Zhao, Jin-Ying
   Xu, Xiao-Hong
   Chai, Jia-Peng
   Zhang, Jia-Xun
   Liu, Jia
   Wang, Fu-Chun
TI Acupoint application therapy alleviates pain by regulating immune function 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Graphene-based warm uterus acupoint paste; Primary dysmenorrhea; Th1/Th2 immune balance; Toll-like receptor 4/myeloid differentiation factor 88/nuclear transcription 
AB OBJECTIVES: To investigate the effects of graphene-based warm uterus acupoint 
   paste on uterine Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 
   (MyD88)/nuclear transcription factor-kappa B p65 (NF-κB p65) signaling pathway 
   and Th1/Th2 immune balance in primary dysmenorrhea ( PD ) model rats, so as to 
   reveal its immunological mechanisms of relieving dysmenorrhea. METHODS: Thirty SD 
   female rats were randomly divided into 3 groups：normal group, model group and 
   acupoint paste group, with 10 rats in each group. PD rat model was established by 
   subcutaneous injection of estradiol benzoate for 10 consecutive days. At the same 
   time of modeling, graphene-based warm uterus acupoint paste was applied to the 
   acupoints of "Guanyuan" (CV4), bilateral "Zigong" (EX-CA1) and "Sanyinjiao" (SP6) 
   of rats in the acupoint paste group. The application was continuously applied 
   once daily for 10 d, 5 h each time. On the 11(th) day, oxytocin was injected 
   intraperitoneally to observe the writhing latency, writhing times within 30 min 
   and writhing score of rats in each group. The spleen and thymus indexes were 
   calculated. The pathological changes of spleen and thymus tissue were observed 
   after HE staining. The contents of serum immunoglobulin (Ig) A, IgG, tumor 
   necrosis factor-α (TNF-α), interleukin (IL)-2, interferon-γ (IFN-γ), IL-4 and 
   IL-10 were detected by ELISA . The protein and mRNA expression levels of TLR4, 
   MyD88 and NF-κB p65 in rat uterine tissue were detected by Western blot and 
   real-time quantitative PCR, respectively. RESULTS: Compared with the normal 
   group, the writhing times and writhing scores within 30 min of rats in the model 
   group were significantly increased(P<0.001), and the rats showed writhing 
   reaction (P<0.01). The spleen index and thymus index were significantly 
   decreased(P<0.01, P<0.05). The spleen and thymus had obvious pathological 
   changes. The contents of IgA, IgG, TNF-α, IL-2 and IFN-γ in serum were 
   significantly increased, while the contents of serum IL-4 and IL-10 were 
   significantly decreased(P<0.001, P<0.01). The expression levels of TLR4, MyD88, 
   NF-κB p65 protein and corresponding mRNA in uterine tissue were significantly 
   increased(P<0.001). Following intervention, compared with the model group, the 
   writhing latency time of rats in the acupoint paste group was prolonged, and the 
   writhing times and writhing scores within 30 min were significantly decreased 
   (P<0.001). The spleen index and thymus index were significantly increased(P<0.01, 
   P<0.05). The pathological changes of spleen and thymus were improved. The 
   contents of serum IgA, IgG, TNF-α, IL-2 and IFN-γ were significantly decreased, 
   while the contents of IL-4 and IL-10 were significantly increased(P<0.001, 
   P<0.05, P<0.01). The expression of TLR4, MyD88, NF-κB p65 protein and the 
   corresponding mRNA levels in uterine tissue were decreased(P<0.001, P<0.01). 
   CONCLUSIONS: Graphene-based warm uterus acupoint paste can regulate the immune 
   balance of Th1/ Th2 by regulating TLR4/ MyD88/ NF-κB p65 signaling pathway, 
   repair the pathological damage of immune tissue, improve immune function, and 
   effectively relieve the pain symptoms of PD rats.
C1 College of Acupuncture-moribustion and Tuina, Changchun University of Chinese Medicine, Changchun 130117, China.
   College of Acupuncture-moribustion and Tuina, Changchun University of Chinese Medicine, Changchun 130117, China.
   College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117.
   College of Acupuncture-moribustion and Tuina, Changchun University of Chinese Medicine, Changchun 130117, China.
   College of Acupuncture-moribustion and Tuina, Changchun University of Chinese Medicine, Changchun 130117, China.
   College of Acupuncture-moribustion and Tuina, Changchun University of Chinese Medicine, Changchun 130117, China.
   College of Acupuncture-moribustion and Tuina, Changchun University of Chinese Medicine, Changchun 130117, China.
   College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117.
   College of Acupuncture-moribustion and Tuina, Changchun University of Chinese Medicine, Changchun 130117, China. fuchenwang420@126.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JAN 19
PY 2024
VL 49
IS 1
BP 37
EP 46
DI 10.13702/j.1000-0607.20230709 
PG 9
WC Humans; Rats; Female; Animals; Rats, Sprague-Dawley; Dysmenorrhea; genetics; NF-kappa B; genetics; Myeloid Differentiation Factor 88; genetics; Acupuncture Points; Toll-Like Receptor 4; genetics; Interleukin-2; Interleukin-10; Tumor Necrosis Factor-alpha; Graphite; Interleukin-4; Signal Transduction; RNA, Messenger; Immunity; Immunoglobulin A; Immunoglobulin G
UT PubMed:38239137
PM 38239137
DA 2024-01-19
ER

PT J
AU English, RE
   Chen, JH
AF English, R E
   Chen, J H
TI Stereotactic core biopsy of an impalpable screen-detected breast lesion using 
SO The British journal of radiology
LA English
DT Journal Article
AB Chinese acupuncture-analgesia is used for pain management during various surgical 
   procedures. Over the past 40 years this approach has been introduced in many 
   countries and has been particularly helpful in the investigation and treatment of 
   patients who are unable to tolerate conventional analgesia. We report here the 
   case of a woman with a 17-year history of myalgic encephalitis who underwent a 
   stereotactic core biopsy of the breast under acupuncture-analgesia. A planning 
   session was needed to assess the patient's existing condition and her response to 
   acupuncture. During this session, a range of frequencies for electrical 
   stimulation of the acupuncture needles using electro-acupuncture apparatus was 
   determined. We describe the combined acupuncture and biopsy procedures and the 
   patient's impressions and outcomes are recorded.
C1 Oxford Breast Imaging Centre, Churchill Hospital, Oxford Radcliffe Hospitals NHS Trust, Old Road, Headington, Oxford, UK. ruth.english@orh.nhs.uk
NR 0
TC 0
SN 1748-880
EI 0007-128
J9 Br J Radiol
PD SEP 18
PY 2010
VL 83
IS 994
BP e208
EP 10
DI 10.1259/bjr/20216505 
PG 1
WC Acupuncture Analgesia; methods; Biopsy, Needle; Breast Neoplasms; pathology; Carcinoma, Intraductal, Noninfiltrating; pathology; Electroacupuncture; methods; Female; Humans; Middle Aged; Pain; psychology; Pain Management; Patient Satisfaction
UT PubMed:20846978
PM 20846978
DA 2010-09-18
ER

PT J
AU Crew, KD
   Capodice, JL
   Greenlee, H
   Brafman, L
   Fuentes, D
   Awad, D
   Yann, Tsai W
   Hershman, DL
AF Crew, Katherine D
   Capodice, Jillian L
   Greenlee, Heather
   Brafman, Lois
   Fuentes, Deborah
   Awad, Danielle
   Yann Tsai, Wei
   Hershman, Dawn L
TI Randomized, blinded, sham-controlled trial of acupuncture for the management of 
SO Journal of clinical oncology : official journal of the American Society of 
LA English
DT Journal Article
AB PURPOSE Women with breast cancer (BC) treated with aromatase inhibitors (AIs) may 
   experience joint symptoms that can lead to discontinuation of effective therapy. 
   We examined whether acupuncture improves AI-induced arthralgias in women with 
   early-stage BC. METHODS We conducted a randomized, controlled, blinded study 
   comparing true acupuncture (TA) versus sham acupuncture (SA) twice weekly for 6 
   weeks in postmenopuasal women with BC who had self-reported musculoskeletal pain 
   related to AIs. TA included full body/auricular acupuncture and joint-specific 
   point prescriptions, whereas SA involved superficial needle insertion at 
   nonacupoint locations. Outcome measures included the Brief Pain Inventory-Short 
   Form (BPI-SF), Western Ontario and McMaster Universities Osteoarthritis Index 
   (WOMAC), and Modified Score for the Assessment of Chronic Rheumatoid Affections 
   of the Hands (M-SACRAH) obtained at baseline and at 3 and 6 weeks. Results Of 51 
   women enrolled, 43 women were randomly assigned and 38 were evaluable. Baseline 
   characteristics were comparable between the two groups. Our primary end point was 
   the difference in mean BPI-SF worst pain scores at 6 weeks, which was lower for 
   TA compared with SA (3.0 v 5.5; P < .001). We also found differences between TA 
   and SA in pain severity (2.6 v 4.5; P = .003) and pain-related interference (2.5 
   v 4.5; P = .002) at 6 weeks. Similar findings were seen for the WOMAC and 
   M-SACRAH scores. The acupuncture intervention was well-tolerated. CONCLUSION 
   Women with AI-induced arthralgias treated with TA had significant improvement of 
   joint pain and stiffness, which was not seen with SA. Acupuncture is an effective 
   and well-tolerated strategy for managing this common treatment-related side 
   effect.
C1 Columbia University, 161 Fort Washington Ave, 10-1068, New York, NY 10032, USA. dlh23@columbia.edu
NR 0
TC 0
SN 1527-775
EI 
J9 J Clin Oncol
PD JAN 27
PY 2010
VL 28
IS 7
BP 1154
EP 60
DI 10.1200/JCO.2009.23.4708 
PG -1094
WC Acupuncture Therapy; Adult; Aged; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Female; Humans; Middle Aged; Neoplasm Staging
UT PubMed:20100963
PM 20100963
DA 2010-01-27
ER

PT J
AU Zhang, X
   Fan, XN
   Ding, L
   Zhang, HT
   Wu, LZ
   Wang, HR
AF Zhang, Xue
   Fan, Xiao-Nong
   Ding, Luo
   Zhang, Hai-Tao
   Wu, Lian-Zhong
   Wang, Hai-Rong
TI [Acupuncture treatment of regulating spirit, activating blood and relieving pain 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB OBJECTIVE: To compare the clinical effect of acupuncture treatment and western 
   medicine Carbamazepine for thalamic pain. METHODS: Crossover trial design was 
   used, 11 cases diagnosed as thalamic pain were randomly divided into two groups 
   according to the mini-unbalance-index method, group I (with 6 cases received 
   acupuncture first and then western medicine) and group II (with 5 cases received 
   western medicine first and then acupuncture). When the effects were evaluated, 
   the two groups were named as acupuncture group and western medicine group, 11 
   cases in each group. The method of clearing away the heart fire, regulating the 
   spirit, activating blood and relieving pain was adopted in acupuncture treatment, 
   Ximen (PC 4), Yinxi (HT 6), Xuehai (SP 10) and Zhaohai (KI 6) were selected; the 
   western medicine group was treated with oral administration of Carbamazepine, and 
   one course as well as the eluting period were both 10 days. The effects were 
   evaluated with visual analogue scale (VAS) and evaluation scale of Anderson 
   Cancer Center pain in US (MD Pain Evaluation value) respectively. RESULTS: The 
   VAS and MD value in two groups were obviously decreased after treatment (both P < 
   0.05), while there was no significant difference between two groups; the markedly 
   effective rate of pain relieving in acupuncture group was 63.6% (7/11), which was 
   higher than that of 36.4% (4/11) in western medicine group, but there was no 
   significant difference between two groups. CONCLUSION: Acupuncture treatment of 
   regulating spirit, activating blood and relieving pain has a better therapeutic 
   effect for thalamic pain, and can reach to the same therapeutic effect with 
   western medicine Carbamazepine.
C1 Tianjin University of TCM, Tianjin 300193, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUN 4
PY 2010
VL 30
IS 5
BP 367
EP 70
DI 
PG -297
WC Acupuncture Therapy; Adult; Aged; Blood Circulation; Carbamazepine; therapeutic use; Cross-Over Studies; Female; Humans; Male; Medicine, Chinese Traditional; Middle Aged; Pain; physiopathology; Pain Management; Pain Measurement; Spirituality; Thalamus; physiopathology
UT PubMed:20518170
PM 20518170
DA 2010-06-04
ER

PT J
AU Zhou, M
   Yang, S
   Chen, RX
   Yang, XF
   Zhao, J
   Xie, WX
   Liao, Y
   Liu, D
AF Zhou, Mei
   Yang, Shuo
   Chen, Ri-Xin
   Yang, Xiao-Fang
   Zhao, Jing
   Xie, Wen-Xuan
   Liao, Yue
   Liu, Dong
TI [Clinical efficacy observation of heat-sensitive moxibustion combined with 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Heat-sensitive moxibustion; Intrapleural infusion of cisplatin; Malignant pleural effusion; Randomized controlled trial
AB OBJECTIVES: To investigate the clinical efficacy of heat-sensitive moxibustion 
   combined with intrapleural perfusion of cisplatin in comparison with simple 
   intrapleural perfusion of cisplatin on malignant pleural effusion (MPE). METHODS: 
   Forty patients with MPE, in compliance with the inclusion criteria, were randomly 
   divided into an observation group (20 cases) and a control group (20 cases). In 
   the control group, cisplatin solution (60 mg/m(2)) was injected into the thoracic 
   cavity after pleural drainage under B-ultrasound positioning, once a week for 4 
   weeks. In the observation group, based on the intervention as the control group, 
   the heat-sensitive moxibustion was delivered at the back and lumbar region (where 
   Feishu ［BL13］, Pishu ［BL20］ and Shenshu ［BL23］ are located) and the chest-abdomen 
   region (where Danzhong ［CV17］, Guanyuan ［CV4］ and Shuidao ［ST28］ are located), 
   for 30 min to 90 min, once daily (the treatment was discontinued on Saturday and 
   Sunday) and for 4 weeks. Before and after treatment, in the two groups, the 
   pleural effusion volume was detected using B ultrasound, the activity of daily 
   living was evaluated with Karnofsky performance statue (KPS) scale and TCM 
   symptoms with TCM syndrome grading scale. The clinical therapeutic effect was 
   evaluated in the two groups. According to the classification criteria table for 
   acute and subacute toxicity of anticancer drugs made by WHO, the toxic and side 
   reaction was judged. RESULTS: After treatment, the pleural effusion volume was 
   reduced in comparison with that before treatment in the two groups (P<0.01, 
   P<0.001), and the volume in the observation group was lower than that of the 
   control group (P<0.05). KPS score was increased in the two groups after treatment 
   compared with that before treatment (P<0.001), and the score in the observation 
   group was higher than that of the control group (P<0.05). After treatment, the 
   total score of TCM syndromes and the scores for dyspnea, cough and chest pain 
   were lower than those before treatment in the two groups (P<0.001), and the 
   scores in the observation group were lower than those of the control group 
   (P<0.001, P<0.05). The scores for anorexia and lassitude were reduced in 
   comparison with those before treatment in the observation group (P<0.001)；and the 
   scores in the observation group were lower than those in the control group after 
   treatment (P<0.001, P<0.01). After treatment, the effective rate of the 
   observation group was 65.0%(13/20), which was higher than that of the control 
   group (30.0%, 6/20, P<0.05). The incidence of bone marrow suppression in the 
   observation group was 15.0%(3/20), lower than that in the control group (55.0%, 
   11/20, P<0.05). The incidence of gastrointestinal reactions in the observation 
   group was 30.0%, lower than that in the control group (65.0%, 13/20, P<0.05). 
   CONCLUSIONS: Heat-sensitive moxibustion combined with intrapleural infusion of 
   cisplatin is superior to intrapleural infusion of cisplatin in the aspects of the 
   amelioration of pleural effusion, daily-living activity and TCM syndromes in 
   patients with MPE. This combined therapy presents the synergism by cooperating 
   with chemotherapeutics and reduces the incidence of toxic and side effects 
   implicated in chemotherapy so as to attenuate the toxicity of chemotherapeutics.
C1 Acupuncture Rehabilitation Department, Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550003, China.
   Acupuncture Rehabilitation Department, Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550003, China.1404326639@qq.com.
   Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006.
   College of Acupuncture-Moxibustion and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang 550002.
   College of Acupuncture-Moxibustion and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang 550002.
   College of Acupuncture-Moxibustion and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang 550002.
   Acupuncture Rehabilitation Department, Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550003, China.
   Acupuncture Rehabilitation Department, Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550003, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD NOV 19
PY 2024
VL 49
IS 11
BP 1190
EP 1197
DI 10.13702/j.1000-0607.20230821 
PG 7
WC Humans; Moxibustion; Cisplatin; administration & dosage; Male; Female; Middle Aged; Pleural Effusion, Malignant; therapy; Aged; Adult; Treatment Outcome; Combined Modality Therapy; Acupuncture Points; Antineoplastic Agents; administration & dosage
UT PubMed:39557436
PM 39557436
DA 2024-11-19
ER

PT J
AU Brulé, S
AF Brulé, Sabine
TI [Auriculotherapy, an anodyne technique in oncology].
SO Soins; la revue de reference infirmiere
LA fre
DT Journal Article
AB Auriculotherapy is a complementary therapy recommended for the treatment of 
   chronic pain. Effectively, the whole of the body's innervation territory is 
   mapped out on the ear auricles, "connected" on the level of the brainstem, the 
   relay station of all the body's sensory information. The therapy consists in 
   inserting semi-permanent needles or localised stimulations in the auricles. The 
   ear point is determined on the basis of neurophysiological reasoning.
C1 Centre anticancéreux de l'Institut Gustave Roussy, Villejuif. sabine.brule@wanadoo.fr
NR 0
TC 0
SN 
EI 0038-081
J9 Soins
PD OCT 19
PY 2011
VL 0
IS 758
BP 45
EP 6
DI 
PG -39
WC Acupuncture Points; Acupuncture, Ear; nursing; Auriculotherapy; nursing; Chronic Pain; nursing; Ear, External; innervation; France; Neoplasms; nursing; Neuralgia; nursing; Reflexotherapy; nursing; Treatment Outcome
UT PubMed:22003795
PM 22003795
DA 2011-10-19
ER

PT J
AU Ondrejkovicova, A
   Petrovics, G
   Svitkova, K
   Balogh, V
AF Ondrejkovicova, Alena
   Petrovics, Gabriel
   Svitkova, Katarína
   Balogh, Vladimír
TI Is non-pharmacological treatment an effective option for chronic low back pain?
SO Neuro endocrinology letters
LA English
DT Journal Article
AB OBJECTIVE: Despite of pain being important warning signal for body ability to 
   respond to internal or external threats, chronic pain is perceived as a 
   discomfort by patients, leading to somatic, emotional and social negative 
   changes. Lifestyle, wrong seating habits and some occupations may contribute to 
   chronic back pain. Therapy for chronic back pain should include not only 
   pharmacological or invasive interventions, but mostly change of lifestyle, 
   physiotherapy and non-pharmacological methods. METHODS: The main objective of the 
   paper was to compare subjective perception of the effectiveness of various 
   methods for treatment of low back pain. In total, 100 patients were asked to fill 
   the questionnaire after completing the treatment, whether conventional or 
   non-pharmacological. We have aimed to analyze not only the perception of the 
   patients, but also indicators of the patient's lifestyle, their nutrition and 
   physical activity. RESULTS: Oral drugs was the most effective option perceived by 
   the patients, followed by non-pharmacological methods, such as massages, heat 
   application and acupuncture. At the same time, all patients who changed their 
   lifestyle, for example reduced smoking and alcohol and increased physical 
   activity, achieved better results in non-pharmacological treatment and 
   experienced higher pain alleviation compared to the patients treated by 
   medications only. CONCLUSION: Non-pharmacological therapy of chronic 
   non-malignant low back pain could be an effective option offered in combination 
   with medicaments and change of lifestyle.
C1 Department of Acupuncture, Institute of Traditional Chinese Medicine, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
   Department of Acupuncture, Institute of Traditional Chinese Medicine, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
   Department of Acupuncture, Institute of Traditional Chinese Medicine, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
   Department of Acupuncture, Institute of Traditional Chinese Medicine, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
NR 0
TC 0
SN 
EI 0172-780
J9 Neuro Endocrinol Lett
PD AUG 2
PY 2017
VL 38
IS 3
BP 169
EP 172
DI 
PG 3
WC Acupuncture Therapy; Analgesics; therapeutic use; Chronic Pain; drug therapy; Exercise; physiology; Female; Health Behavior; physiology; Hot Temperature; therapeutic use; Humans; Life Style; Low Back Pain; drug therapy; Male; Massage; Pain Management; methods; Pain Measurement; Pain Perception; physiology; Physical Therapy Modalities; Treatment Outcome
UT PubMed:28759184
PM 28759184
DA 2017-08-02
ER

PT J
AU Greenlee, H
   Crew, KD
   Capodice, J
   Awad, D
   Buono, D
   Shi, Z
   Jeffres, A
   Wyse, S
   Whitman, W
   Trivedi, MS
   Kalinsky, K
   Hershman, DL
AF Greenlee, Heather
   Crew, Katherine D
   Capodice, Jillian
   Awad, Danielle
   Buono, Donna
   Shi, Zaixing
   Jeffres, Anne
   Wyse, Sharon
   Whitman, Wendy
   Trivedi, Meghna S
   Kalinsky, Kevin
   Hershman, Dawn L
TI Randomized sham-controlled pilot trial of weekly electro-acupuncture for the 
SO Breast cancer research and treatment
LA English
DT Journal Article
DE Acupuncture; Breast cancer; Chemotherapy-induced peripheral neuropathy; Electro-acupuncture; Taxane
AB To investigate the effect of electro-acupuncture (EA) as a non-pharmacological 
   intervention to prevent or reduce chemotherapy-induced peripheral neuropathy 
   (CIPN) in breast cancer patients undergoing chemotherapy of taxane. Women with 
   stage I-III breast cancer scheduled to receive taxane therapy were randomized to 
   receive a standardized protocol of 12 true or sham EA (SEA) weekly treatments 
   concurrent with taxane treatment. Subjects completed the Brief Pain 
   Inventory-Short Form (BPI-SF), Functional Assessment of Cancer Therapy-Taxane 
   neurotoxicity subscale (FACT-NTX), and other assessments at baseline and weeks 6, 
   12, and 16. A total of 180 subjects were screened, 63 enrolled and 48 completed 
   week 16 assessments. Mean age was 50 with 25 % white, 25 % black, and 43 % 
   Hispanic; 52 % had no prior chemotherapy. At week 12, both groups reported an 
   increase in mean BPI-SF worst pain score, but no mean differences were found 
   between groups (SEA 2.8 vs. EA 2.6, P = .86). By week 16, the SEA group returned 
   to baseline, while the EA group continued to worsen (SEA 1.7 vs. EA 3.4, P = 
   .03). The increase in BPI-SF worst pain score was 1.62 points higher in the EA 
   group than in the SEA group at week 16 (P = .04). In a randomized, 
   sham-controlled trial of EA for prevention of taxane-induced CIPN, there were no 
   differences in pain or neuropathy between groups at week 12. Of concern, subjects 
   on EA had a slower recovery than SEA subjects. Future studies should focus on EA 
   for treatment as opposed to prevention of CIPN.
C1 Mailman School of Public Health, Columbia University, New York, NY, USA. hg2120@columbia.edu.
   Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 
   Columbia University, 722 W. 168th Street, Room 733, New York, NY, 10032, USA. hg2120@columbia.edu.
   Mailman School of Public Health, Columbia University, New York, NY, USA.
   Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 
   College of Physicians and Surgeons, Columbia University, New York, NY, USA.
   Mount Sinai School of Medicine, New York, NY, USA.
   Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
   College of Physicians and Surgeons, Columbia University, New York, NY, USA.
   Mailman School of Public Health, Columbia University, New York, NY, USA.
   Mailman School of Public Health, Columbia University, New York, NY, USA.
   Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
   Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
   Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
   College of Physicians and Surgeons, Columbia University, New York, NY, USA.
   Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
   College of Physicians and Surgeons, Columbia University, New York, NY, USA.
   Mailman School of Public Health, Columbia University, New York, NY, USA.
   Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 
   College of Physicians and Surgeons, Columbia University, New York, NY, USA.
NR 0
TC 0
SN 1573-721
EI 0167-680
J9 Breast Cancer Res Treat
PD MAR 26
PY 2016
VL 156
IS 3
BP 453
EP 464
DI 10.1007/s10549-016-3759-2 
PG 11
WC Adult; Aged; Breast Neoplasms; drug therapy; Bridged-Ring Compounds; adverse effects; Double-Blind Method; Electroacupuncture; methods; Female; Humans; Middle Aged; Peripheral Nervous System Diseases; chemically induced; Pilot Projects; Taxoids; adverse effects; Treatment Outcome
UT PubMed:27013473
PM 27013473
DA 2016-03-26
ER

PT J
AU Lee, JH
   Cho, TJ
   Park, MG
   Kim, JH
   Song, SK
   Park, SY
   Sunwoo, YY
   Lee, I
   Park, TY
AF Lee, Jin-Hyun
   Cho, Tae Jin
   Park, Min Geun
   Kim, Ji-Hoon
   Song, Sung Kyu
   Park, Shin-Young
   Sunwoo, Yun-Young
   Lee, Ilkyun
   Park, Tae-Yong
TI Clinical study on concurrent use of electro-acupuncture or Chuna manual therapy 
SO Medicine
LA English
DT Journal Article
AB INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the 
   major side effects of chemotherapy. Its main symptoms are pain, paresthesia, and 
   numbness. However, the mechanisms underlying the development of CIPN remain 
   unclear and standard treatments have not been established. Recently, there has 
   been a growing interest in various approaches to overcome the limitations of the 
   existing treatments. This study aims to evaluate the efficacy and safety of the 
   concurrent use of two complementary and alternative therapies: electroacupuncture 
   (EA) and Chuna manual therapy (CMT), with pregabalin, which is the conventional 
   pharmacotherapy for neuropathic pain. METHODS/DESIGN: This is an open-label, 
   parallel, assessor-blinded randomized controlled trial, which includes 90 
   patients with colorectal and breast cancer, who developed CIPN. After a 2-week 
   preparation period, the patients are divided into three groups (pregabalin 
   administration group, pregabalin + EA treatment group, and pregabalin + CMT 
   treatment group), treated for approximately 5 weeks and followed-up 4 weeks after 
   treatment. The primary outcome is assessed using the Functional Assessment of 
   Cancer Therapy/Gynecologic Oncology Group Neurotoxicity subscale score (version 
   4.0) and the secondary outcome is measured using the Quality of Life 
   Questionnaire-CIPN 20-Item Scale (version 3.0) and the quality of life 
   questionnaire (version 3.0) developed by the European Organisation for Research 
   and Treatment of Cancer. Moreover, exploratory efficacy and safety evaluations 
   will be conducted based on the chemotherapy-completion rate and nerve conduction 
   studies.
C1 Institute for Integrative Medicine, Catholic Kwandong University International St. Mary's Hospital.
   Department of Emergency Medicine.
   Department of Surgery, Catholic Kwandong University International St. Mary's Hospital, Catholic Kwandong University College of Medicine.
   Department of Surgery, Catholic University of Korea, Incheon St. Mary's Hospital.
   Department of Surgery, Catholic Kwandong University International St. Mary's Hospital, Catholic Kwandong University College of Medicine.
   Department of Surgery, Catholic Kwandong University International St. Mary's Hospital, Catholic Kwandong University College of Medicine.
   Iksoodang Korean Medical Clinic, Incheon, South Korea.
   Department of Emergency Medicine.
   Institute for Integrative Medicine, Catholic Kwandong University International St. Mary's Hospital.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD FEB 6
PY 2020
VL 99
IS 3
BP e18830
EP e18830
DI 10.1097/MD.0000000000018830 
PG 1
WC Acupuncture Therapy; Analgesics; therapeutic use; Antineoplastic Agents; adverse effects; Humans; Musculoskeletal Manipulations; Peripheral Nervous System Diseases; chemically induced; Pregabalin; therapeutic use; Randomized Controlled Trials as Topic; Research Design
UT PubMed:32011497
PM 32011497
DA 2020-02-06
ER

PT J
AU Jacoby, VL
   Jacoby, A
   Learman, LA
   Schembri, M
   Gregorich, SE
   Jackson, R
   Kuppermann, M
AF Jacoby, Vanessa L
   Jacoby, Alison
   Learman, Lee A
   Schembri, Michael
   Gregorich, Steven E
   Jackson, Rebecca
   Kuppermann, Miriam
TI Use of medical, surgical and complementary treatments among women with fibroids.
SO European journal of obstetrics, gynecology, and reproductive biology
LA English
DT Journal Article
DE Complementary treatments; Myomectomy; Uterine artery embolization; Uterine fibroids
AB OBJECTIVE: To examine the use of medical management, uterus-preserving surgery 
   (UPS), and complementary treatments among women with uterine fibroids. STUDY 
   DESIGN: Prospective cohort study of 933 premenopausal women ages 31-54 years with 
   symptomatic fibroids who participated in the Study of Pelvic Problems, 
   Hysterectomy, and Intervention Alternatives (SOPHIA) for an average of 4.3 years 
   (SD 2.5 years). Incident use of fibroid treatments was determined through annual 
   interviews. Linear regression models were used to compare changes in 
   fibroid-related symptoms among women who underwent UPS versus those who did not 
   undergo surgery. RESULTS: Participants were racially and ethnically diverse, with 
   a mean age of 43 years. During study follow-up, 531 participants (57%) did not 
   undergo UPS or hysterectomy, 250 (27%) had at least one UPS, and 152 (16%) 
   underwent hysterectomy. Complementary and alternative treatments were commonly 
   used, including exercise (45%), diet (34%), herbs (37%), and acupuncture (16%): 
   participants reported significant symptom improvement and few side effects with 
   these interventions. In multivariable linear regression models, women who did not 
   undergo surgery during the study reported improvement in dyspareunia (p<.001), 
   pelvic pain (p<.001), and menstrual cramps (p<.001). However, women who underwent 
   UPS reported greater overall resolution of "pelvic problems" compared with women 
   who did not have surgical treatment (difference in change score 1.18 on a 
   four-point Likert scale, p<.001). CONCLUSION: UPS are effective treatments for 
   women with fibroids, but many women use hormonal or complementary treatments and 
   report significant symptom improvement without surgical intervention.
C1 Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, 1635 Divisadero St, Suite 600, San Francisco, CA, USA. Electronicaddress: jacobyv@obgyn.ucsf.edu.
   Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, 1635 Divisadero St, Suite 600, San Francisco, CA, USA.
   Department of Obstetrics and Gynecology, Indiana University School of Medicine, USA.
   Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, 1635 Divisadero St, Suite 600, San Francisco, CA, USA.
   Medicine, University of California, San Francisco, CA, USA
   Medical Effectiveness Research Center for Diverse Populations, University of California, San Francisco,CA, USA.
   Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, 1635 Divisadero St, Suite 600, San Francisco, CA, USA
   Epidemiology &Biostatistics, University of California, San Francisco, CA, USA.
   Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, 1635 Divisadero St, Suite 600, San Francisco, CA, USA
   Epidemiology &Biostatistics, University of California, San Francisco, CA, USA
   MedicalEffectiveness Research Center for Diverse Populations, University of California,San Francisco, CA, USA.
NR 0
TC 0
SN 1872-765
EI 0301-211
J9 Eur J Obstet Gynecol Reprod Biol
PD DEC 3
PY 2014
VL 182
IS 
BP 220
EP 5
DI 10.1016/j.ejogrb.2014.09.004 
PG -215
WC Acupuncture Therapy; Adult; Analgesics, Opioid; therapeutic use; Anti-Inflammatory Agents, Non-Steroidal; therapeutic use; Contraceptives, Oral, Hormonal; therapeutic use; Diet; Dyspareunia; etiology; Endometrial Ablation Techniques; Exercise; Female; Follow-Up Studies; Humans; Hysterectomy; Leiomyoma; complications; Low Back Pain; etiology; Middle Aged; Organ Sparing Treatments; Pelvic Pain; etiology; Plant Preparations; therapeutic use; Prospective Studies; Treatment Outcome; Uterine Artery Embolization; Uterine Hemorrhage; etiology; Uterine Myomectomy; Uterine Neoplasms; complications
UT PubMed:25445104
PM 25445104
DA 2014-12-03
ER

PT J
AU Wu, QL
   Cao, W
   Wang, W
   Jiang, ZY
   Chen, L
   Li, LL
AF Wu, Qiu-Lan
   Cao, Wen
   Wang, Wei
   Jiang, Zi-Yu
   Chen, Li
   Li, Li-Li
TI [Wrist-ankle needle combined with opioid drugs on refractory cancer pain: a 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE analgesia; opioid drugs; randomized controlled trial (RCT); refractory cancer pain; wrist-ankle needle
AB OBJECTIVE: To compare the clinical effect of wrist-ankle needle combined with 
   opioid drugs and opioid drugs alone in treating refractory cancer pain. METHODS: 
   Sixty patients were randomly divided into an observation group and a control 
   group, 30 cases in each one. The opioid drugs in accordance with the three-step 
   analgesic principle and other auxiliary drugs were treated in the control group. 
   On the basis of the treatment in the control group, wrist-ankle needle was added 
   in the observation group, and acupoints were selected according to the pain site 
   and the primary focus, the treatment was given once a day for 10 days. The visual 
   analogue scale (VAS) score, the times of pain outbreaks and the incidence of 
   adverse reactions were compared at the 2nd, 4th, 6th, 8th and 10th days of 
   treatment and the 3rd and 7th days after treatment. The therapeutic effect in the 
   two groups were compared after treatment. RESULTS: Compared with the control 
   group, the VAS scores in the observation group were significantly reduced from 
   the 2nd day of wrist-ankle needle treatment, and continued to the 3rd day after 
   the end of the treatment (P<0.05), but there was no statistically significant 
   difference between the two groups on the 7th day after the end of the treatment 
   (P>0.05); compared with the control group, the times of pain outbreaks in the 
   observation group decreased from the 2nd day to the 10th day of treatment (all 
   P<0.05); the incidence of nausea, vomiting and constipation in the observation 
   group was significantly reduced compared with the control group (P<0.05); the 
   total effective rate in the observation group was 86.7% (26/30), which was higher 
   than 76.7% (23/30) in the control group (P<0.05). CONCLUSION: Wrist-ankle needle 
   combined with opioid drugs can increase the efficacy of the refractory cancer 
   pain and reduce the adverse reactions of opioid drugs.
C1 Department of Oncology, Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of CM, Nanjing 210028, JiangsuProvince, China.
   Department of Oncology, Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of CM, Nanjing 210028, JiangsuProvince, China.
   Department of Oncology, Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of CM, Nanjing 210028, JiangsuProvince, China.
   Department of Oncology, Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of CM, Nanjing 210028, JiangsuProvince, China.
   Department of Oncology, Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of CM, Nanjing 210028, JiangsuProvince, China.
   Department of Oncology, Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of CM, Nanjing 210028, JiangsuProvince, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD OCT 18
PY 2019
VL 39
IS 10
BP 1051
EP 4
DI 10.13703/j.0255-2930.2019.10.005 
PG -1047
WC Acupuncture Analgesia; methods; Analgesics, Opioid; therapeutic use; Ankle; Cancer Pain; therapy; Humans; Treatment Outcome; Wrist
UT PubMed:31621255
PM 31621255
DA 2019-10-18
ER

PT J
AU Giralt, I
   Carvajal, GD
   Fabregas, R
   Baulies, S
AF Giralt, Isabel
   Carvajal, Gilda Delmira
   Fabregas, Rafael
   Baulies, Sonia
TI [Scientific letter evaluating acupuncture and auriculotherapy action in 
SO Atencion primaria
LA spa
DT Letter
C1 Unidad de Acupuntura Clínica Mujer Dexeus, Barcelona, Sociedad Médica Profesional ENERGIMED-2007, Barcelona, España. 
   Unidad de Acupuntura Clínica Mujer Dexeus, Barcelona, Sociedad Médica Profesional ENERGIMED-2007, Barcelona, España.
   Clínica Mujer Dexeus, Barcelona, España.
   Clínica Mujer Dexeus, Barcelona, España.
EM isagiralt@gmail.com
NR 0
TC 0
SN 1578-127
EI 0212-656
J9 Aten Primaria
PD SEP 11
PY 2023
VL 55
IS 12
BP 102740
EP 102740
DI 10.1016/j.aprim.2023.102740 
PG 0
WC Humans; Female; Breast Neoplasms; drug therapy; Acupuncture Therapy; adverse effects; Auriculotherapy; Arthralgia; therapy; Hormones
UT PubMed:37690338
PM 37690338
DA 2023-09-11
ER

PT J
AU Walter, M
   Sammer, U
   Kessler, TM
AF Walter, M
   Sammer, U
   Kessler, T M
TI [Chronic pelvic pain syndrome: neurostimulation, neuromodulation and 
SO Der Urologe. Ausg. A
LA ger
DT Journal Article
AB Chronic pelvic pain syndrome (CPPS) is defined by the European Association of 
   Urology guidelines as a non-malignant pain perceived in structures related to the 
   pelvis of either women or men for at least 6 months without proven infection or 
   other obvious pathology. It affects the quality of life of millions of people 
   worldwide and has an impact similar to that reported for other chronic diseases, 
   such as diabetes mellitus, Crohn's disease and congestive heart failure. The 
   treatment of CPPS remains a challenge despite several established first line 
   therapies because many patients are therapy refractory. Unconventional 
   treatments, such as neurostimulation, neuromodulation and acupuncture may be 
   highly successful for treating CPPS and have a favorable adverse event profile. 
   Thus, these promising therapeutic alternatives should be considered more often in 
   daily clinical practice.
C1 Neuro-Urologie, Zentrum für Paraplegie, Uniklinik Balgrist, Universität Zürich, Forchstraße 340, CH-8008 Zürich, Schweiz.
NR 0
TC 0
SN 1433-056
EI 
J9 Urologe A
PD DEC 12
PY 2012
VL 51
IS 12
BP 1683
EP 91
DI 10.1007/s00120-012-3037-9 
PG -1592
WC Chronic Pain; rehabilitation; Electroacupuncture; methods; Female; Germany; Humans; Male; Pelvic Pain; rehabilitation; Syndrome; Transcutaneous Electric Nerve Stimulation; methods; Treatment Outcome
UT PubMed:23224254
PM 23224254
DA 2012-12-12
ER

PT J
AU Psutka, SP
   Veleber, S
   Siman, J
   Holt, SK
   Jannat, S
   Wright, JL
   Lin, DW
   Gore, JL
   Schade, GR
   Annen, Z
   Greenlee, H
AF Psutka, Sarah P
   Veleber, Susan
   Siman, Jonathan
   Holt, Sarah K
   Jannat, Samia
   Wright, Jonathan L
   Lin, Daniel W
   Gore, John L
   Schade, George R
   Annen, Zachary
   Greenlee, Heather
TI Phase 1/2 Randomized Clinical Trial of In-clinic acupuncture Prior to Bacillus 
SO European urology oncology
LA English
DT Journal Article
DE Acupuncture; Bacillus Calmette-Guérin; Bladder cancer; Health-related quality of life; Toxicity
AB BACKGROUND: Treatment-related dose-limiting dysuria and irritative bladder 
   symptoms are common in patients receiving intravesical bacillus Calmette-Guérin 
   (BCG) to treat non-muscle-invasive bladder cancer (NMIBC). Acupuncture has been 
   shown to reduce pain and urinary urgency/frequency in other patient populations. 
   OBJECTIVE: To evaluate the feasibility, safety, and tolerability of weekly 
   in-clinic preprocedural acupuncture among patients receiving induction BCG. 
   DESIGN, SETTING, AND PARTICIPANTS: Patients with high-risk NMIBC undergoing 
   induction BCG were randomized 2:1 to a standardized acupuncture protocol 
   (acupuncture) versus the standard-of-care control arm. INTERVENTION: In-office 
   acupuncture prior to each BCG instillation. OUTCOME MEASUREMENTS AND STATISTICAL 
   ANALYSES: Feasibility was assessed via recruitment, retention, and intervention 
   adherence. Acupuncture safety and tolerability were assessed via 
   physician-reported Common Terminology Criteria for Adverse Events version 5.0 and 
   adverse events (AEs). Secondary endpoints included BCG treatment adherence, 
   patient-reported BCG-related toxicity, and bladder cancer-specific and generic 
   (European Organisation for Research and Treatment of Cancer [EORTC]-QLQ-NMIBC-24 
   and EORTC-QLQ-NMIBC-C30) quality of life (QOL). Subjective assessments of 
   acupuncture acceptability were performed through patient surveys. RESULTS AND 
   LIMITATIONS: A total of 43 individuals were randomized 2:1 to the acupuncture 
   (n = 28) versus control (n = 15) group. The median age was 70.3 yr, and 76% were 
   male. Week 7 follow-up surveys were completed by 93%; six participants withdrew 
   early due to disease progression, refractory gross hematuria, or preference. 
   Acupuncture was delivered successfully prior to each BCG treatment, with no 
   acupuncture-related AEs or interruptions to induction BCG. BCG-attributed AEs 
   were reported by 91% acupuncture and 100% control individuals, including pain 
   (28% vs 43%, p = 0.34) and urinary symptoms (62% vs 79%, p = 0.31). Comparing 
   acupuncture patients with controls, change in QOL over the study period 
   demonstrated greater improvements in median urinary symptoms (9.5, interquartile 
   range [IQR] 0.0-19.0 vs 0.0, IQR -14.3 to 7.1; p = 0.02) among patients in the 
   acupuncture arm. Of the acupuncture patients, 96% reported that acupuncture was 
   "very/extremely helpful," and 91% would recommend acupuncture to other patients. 
   Limitations include modest sample size and single-institution design. 
   CONCLUSIONS: Acupuncture prior to induction BCG treatments is feasible and safe. 
   In this phase 1/2 trial, improved urinary function scores were observed among 
   patients undergoing acupuncture. Patients receiving acupuncture reported high 
   degrees of satisfaction with treatments. PATIENT SUMMARY: We evaluated the safety 
   and feasibility of delivering acupuncture in a urology clinic prior to weekly 
   intravesical bladder cancer treatments with bacillus Calmette-Guérin (BCG) in a 
   randomized controlled trial. We found that acupuncture could be delivered safely 
   prior to weekly BCG instillations and that the use of acupuncture was associated 
   with high patient satisfaction and a decrease in patient-reported urinary 
   symptoms compared with usual care.
C1 Department of Urology, University of Washington School of Medicine, Seattle, WA, USA. 
   Integrative Medicine Program, Division of Supportive Care, Fred Hutchinson Cancer Center, Seattle, WA, USA
   Division of Public Health Sciences, Fred HutchinsonCancer Center, Seattle, WA, USA.
   Integrative Medicine Program, Division of Supportive Care, Fred Hutchinson Cancer Center, Seattle, WA, USA
   Division of Public Health Sciences, Fred HutchinsonCancer Center, Seattle, WA, USA
   Division of Medical Oncology, Department ofMedicine, University of Washington School of Medicine, Seattle, WA, USA.
   Department of Urology, University of Washington School of Medicine, Seattle, WA, USA
   Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
   Department of Urology, University of Washington School of Medicine, Seattle, WA, USA.
   Department of Urology, University of Washington School of Medicine, Seattle, WA, USA
   Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle,WA, USA.
   Department of Urology, University of Washington School of Medicine, Seattle, WA, USA.
   Department of Urology, University of Washington School of Medicine, Seattle, WA, USA.
   Department of Urology, University of Washington School of Medicine, Seattle, WA, USA.
   Department of Urology, University of Washington School of Medicine, Seattle, WA, USA.
   Integrative Medicine Program, Division of Supportive Care, Fred Hutchinson Cancer Center, Seattle, WA, USA
   Division of Public Health Sciences, Fred HutchinsonCancer Center, Seattle, WA, USA
   Division of Medical Oncology, Department ofMedicine, University of Washington School of Medicine, Seattle, WA, USA
   ClinicalResearch Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
EM spsutka@uw.edu
NR 0
TC 0
SN 2588-931
EI 
J9 Eur Urol Oncol
PD APR 24
PY 2024
VL 7
IS 6
BP 1431
EP 1440
DI 10.1016/j.euo.2024.04.002 
PG 9
WC Humans; Urinary Bladder Neoplasms; therapy; Male; BCG Vaccine; therapeutic use; Female; Aged; Acupuncture Therapy; methods; Middle Aged; Administration, Intravesical; Adjuvants, Immunologic; therapeutic use; Neoplasm Invasiveness; Feasibility Studies; Quality of Life; Non-Muscle Invasive Bladder Neoplasms
UT PubMed:38653622
PM 38653622
DA 2024-04-24
ER

PT J
AU Guo, X
   Zhao, Y
   Huang, F
   Li, S
   Luo, M
   Wang, Y
   Zhang, J
   Li, L
   Zhang, Y
   Jiao, Y
   Zhao, B
   Wang, J
   Meng, H
   Zhang, Z
   Rong, P
AF Guo, Xiao
   Zhao, Yuanyuan
   Huang, Feng
   Li, Shaoyuan
   Luo, Man
   Wang, Yu
   Zhang, Jinling
   Li, Liang
   Zhang, Yue
   Jiao, Yue
   Zhao, Bin
   Wang, Junying
   Meng, Hong
   Zhang, Zhangjin
   Rong, Peijing
TI Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Peripheral and 
SO Neural plasticity
LA English
DT Journal Article
AB Depression and pain disorders share a high degree of comorbidity. Inflammatory 
   mechanisms play an important role in the pathogenesis of depression-chronic 
   somatic pain comorbidity. In this study, we investigated the effects of 
   acupuncture on blood and brain regional tumor necrosis factor alpha (TNF-α) in 
   rats with depression and chronic somatic pain comorbidity. Forty Sprague-Dawley 
   rats were randomly divided into the following 4 groups with 10 each: control, 
   model, model treated with transcutaneous auricular vagus nerve stimulation 
   (taVNS), and model treated with electroacupuncture (EA). Chronic unpredictable 
   mild stress (CUMS) with chronic constriction injury of the sciatic nerve (CCI) 
   was used to produce depression and chronic somatic pain comorbidity in the latter 
   3 groups. The rats of the taVNS and EA groups received, respectively, taVNS and 
   EA at ST 36 for 28 days. Pain intensity was measured using a mechanical 
   withdrawal threshold and thermal stimulation latency once biweekly. Depressive 
   behavior was examined using a sucrose preference test at baseline and the end of 
   modeling and intervention. The level of plasma TNF-α and the expression of TNF-α 
   in the prefrontal cortex (PFC), hippocampus, amygdala, and hypothalamus were 
   measured. While CUMS plus CCI produced remarkable depression-like behavior and 
   pain disorders, EA and taVNS significantly improved depression and reduced pain 
   intensity. CUMS plus CCI also resulted in a significant increase in plasma TNF-α 
   level and the expression in all brain regions examined compared to the intact 
   controls. Both EA and taVNS interventions, however, suppressed the elevated level 
   of TNF-α. These results suggest that EA and taVNS have antidepressant and 
   analgesic effects. Such effects may be associated with the suppression of 
   TNF-α-related neuroinflammation.
C1 Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Department of Scientific Research Management, China Academy of Chinese Medical 
   Department of Psychiatry, First Hospital of Hebei Medical University, Shijiazhuang 050031, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, 
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Key Laboratory of Cosmetic, China National Light Industry, Beijing Technology and Business University, Beijing 100048, China.
   The School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
NR 0
TC 0
SN 1687-544
EI 2090-590
J9 Neural Plast
PD NOV 5
PY 2020
VL 2020
IS 
BP 8885729
EP 8885729
DI 10.1155/2020/8885729 
PG 0
WC Acupuncture Therapy; Animals; Brain; metabolism; Depression; metabolism; Male; Nociceptive Pain; metabolism; Rats, Sprague-Dawley; Transcutaneous Electric Nerve Stimulation; Tumor Necrosis Factor-alpha; metabolism; Vagus Nerve Stimulation
UT PubMed:33144854
PM 33144854
DA 2020-11-05
ER

PT J
AU Lu, W
   Rosenthal, DS
AF Lu, Weidong
   Rosenthal, David S
TI Recent advances in oncology acupuncture and safety considerations in practice.
SO Current treatment options in oncology
LA English
DT Journal Article
AB Oncology acupuncture is a new and emerging field of research. Recent advances 
   from published clinical trials have added evidence to support the use of 
   acupuncture for symptom management in cancer patients. Recent new developments 
   include (1) pain and dysfunction after neck dissection; (2) radiation-induced 
   xerostomia in head and neck cancer; (3) aromatase inhibitor-associated arthralgia 
   in breast cancer; (4) hot flashes in breast cancer and prostate cancer; and (5) 
   chemotherapy-induced neutropenia in ovarian cancer. Some interventions are 
   becoming a non-pharmaceutical option for cancer patients, while others still 
   require further validation and confirmation. Meanwhile, owing to the rapid 
   development of the field and increased demands from cancer patients, safety 
   issues concerning oncology acupuncture practice have become imperative. Patients 
   with cancer may be at higher risk developing adverse reactions from acupuncture. 
   Practical strategies for enhancing safety measures are discussed and recommended.
C1 Leonard P. Zakim Center for Integrative Therapies, Dana-Farber Cancer Institute, SW560, 44 Binney Street, Boston, MA 02115, USA. Weidong_lu@dfci.harvard.edu
NR 0
TC 0
SN 1534-627
EI 1527-272
J9 Curr Treat Options Oncol
PD NOV 26
PY 2010
VL 11
IS 3-4
BP 141
EP 6
DI 10.1007/s11864-010-0126-0 
PG -135
WC Acupuncture Therapy; adverse effects; Humans; Medical Oncology; methods; Meta-Analysis as Topic; Neoplasms; therapy
UT PubMed:21103962
PM 21103962
DA 2010-11-26
ER

PT J
AU Li, Y
   Yin, C
   Li, X
   Liu, B
   Wang, J
   Zheng, X
   Shao, X
   Liang, Y
   Du, J
   Fang, J
   Liu, B
AF Li, Yuanyuan
   Yin, Chengyu
   Li, Xiaojie
   Liu, Boyu
   Wang, Jie
   Zheng, Xiaoli
   Shao, Xiaomei
   Liang, Yi
   Du, Junying
   Fang, Jianqiao
   Liu, Boyi
TI Electroacupuncture Alleviates Paclitaxel-Induced Peripheral Neuropathic Pain in 
SO International journal of molecular sciences
LA English
DT Journal Article
DE Paclitaxel; TLR4; TRPV1; acupuncture; dorsal root ganglion; glial cell; peripheral neuropathy
AB Paclitaxel-induced peripheral neuropathy is a common adverse effect during 
   paclitaxel treatment resulting in sensory abnormalities and neuropathic pain 
   during chemotherapy and in cancer survivors. Conventional therapies are usually 
   ineffective and possess adverse effects. Here, we examined the effects of 
   electroacupuncture (EA) on a rat model of paclitaxel-induced neuropathic pain and 
   related mechanisms. EA robustly and persistently alleviated paclitaxel-induced 
   pain hypersensitivities. Mechanistically, TLR4 (Toll-Like Receptor 4) and 
   downstream signaling MyD88 (Myeloid Differentiation Primary Response 88) and 
   TRPV1 (Transient Receptor Potential Vallinoid 1) were upregulated in dorsal root 
   ganglion (DRGs) of paclitaxel-treated rats, whereas EA reduced their 
   overexpression. Ca(2+) imaging further indicated that TRPV1 channel activity was 
   enhanced in DRG neurons of paclitaxel-treated rats whereas EA suppressed the 
   enhanced TRPV1 channel activity. Pharmacological blocking of TRPV1 mimics the 
   analgesic effects of EA on the pain hypersensitivities, whereas capsaicin 
   reversed EA's effect. Spinal astrocytes and microglia were activated in 
   paclitaxel-treated rats, whereas EA reduced the activation. These results 
   demonstrated that EA alleviates paclitaxel-induced peripheral neuropathic pain 
   via mechanisms possibly involving suppressing TLR4 signaling and TRPV1 
   upregulation in DRG neurons, which further result in reduced spinal glia 
   activation. Our work supports EA as a potential alternative therapy for 
   paclitaxel-induced neuropathic pain.
C1 Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou 310053, China.
NR 0
TC 0
SN 1422-006
EI 
J9 Int J Mol Sci
PD NOV 30
PY 2019
VL 20
IS 23
BP 
EP 
DI 10.3390/ijms20235917 
PG 0
WC Animals; Antineoplastic Agents, Phytogenic; toxicity; Electroacupuncture; methods; Gene Expression Regulation; Male; Myeloid Differentiation Factor 88; antagonists & inhibitors; Neuralgia; chemically induced; Paclitaxel; toxicity; Peripheral Nervous System Diseases; chemically ; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; drug effects; TRPV Cation Channels; antagonists & inhibitors; Toll-Like Receptor 4; antagonists & inhibitors
UT PubMed:31775332
PM 31775332
DA 2019-11-30
ER

PT J
AU Wang, F
   Ye, Z
   Yin, X
   Zhou, C
   Zhong, M
   Zhao, G
AF Wang, Feng
   Ye, Zhihui
   Yin, Xiuju
   Zhou, Chengcheng
   Zhong, Min
   Zhao, Gaofeng
TI Electroacupuncture at 5/100 Hz alleviates neuropathic pain in rats by inhibiting 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE CCL3; CCR5; electroacupuncture; glial cells; neuropathic pain; proinflammatory factors
AB OBJECTIVE: Typically, neuropathic pain (NP) is difficult to manage as it is 
   refractory to conventional medications. Electroacupuncture (EA) at 5/100 Hz has 
   emerged as an effective and promising treatment for NP; however, its mechanism of 
   action is still uncertain. Accordingly, this study investigated the alleviatory 
   mechanism of EA in chronic compression injury (CCI)-induced chronic pain via the 
   C-C chemokine ligand 3 / C-C chemokine receptor type 5 (CCL3/CCR5) axis. METHODS: 
   The CCI model was established in rats to induce NP. Mechanical and thermal 
   hyperalgesia were assessed with von Frey and Hargreaves tests, respectively. From 
   day 8 after CCI, EA (5/100 Hz) was performed for 1 week (30 min/day). CCL3 and 
   CCR5 expression was detected with Western blotting and immunofluorescence. Glial 
   cell activation was determined through co-labeling of neurons and glial cells 
   with antibodies against CCL3 and CCR5. The release of interleukin (IL)-1β, IL-6 
   and tumor necrosis factor (TNF)-α was tested with enzyme-linked immunosorbent 
   assay (ELISA). RESULTS: EA markedly ameliorated CCI-induced chronic NP in rats 
   and reduced CCL3 and CCR5 expression in the rat spinal cord. CCL3 and CCR5 were 
   co-expressed by neurons and microglia in the central nervous system. In addition, 
   EA also repressed the activation of glial cells and levels of IL-1β, IL-6 and 
   TNF-α. CONCLUSION: EA may mitigate chronic NP in rats by blocking the CCL3/CCR5 
   axis in the spinal cord. In addition, EA appeared to exert anti-inflammatory and 
   analgesic effects by suppressing glial cell activation. These findings add to our 
   understanding of the mechanism of EA-induced analgesia.
C1 Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
   Guangzhou University of Chinese Medicine, Guangzhou, China.
   Guangzhou University of Chinese Medicine, Guangzhou, China.
   Guangzhou University of Chinese Medicine, Guangzhou, China.
   Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
   Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD MAR 22
PY 2025
VL 43
IS 2
BP 95
EP 103
DI 10.1177/09645284251327197 
PG 8
WC Animals; Electroacupuncture; Receptors, CCR5; genetics; Neuralgia; therapy; Spinal Cord; metabolism; Rats; Male; Chemokine CCL3; genetics; Rats, Sprague-Dawley; Humans; Disease Models, Animal
UT PubMed:40119762
PM 40119762
DA 2025-03-22
ER

PT J
AU Lu, W
   Posner, MR
   Wayne, P
   Rosenthal, DS
   Haddad, RI
AF Lu, Weidong
   Posner, Marshall R
   Wayne, Peter
   Rosenthal, David S
   Haddad, Robert I
TI Acupuncture for dysphagia after chemoradiation therapy in head and neck cancer: a 
SO Integrative cancer therapies
LA English
DT Journal Article
AB BACKGROUND: Dysphagia is a common side effect following chemoradiation therapy 
   (CRT) in patients with head and neck cancer (HNC). METHODS: In this retrospective 
   case series, 10 patients with HNC were treated with acupuncture for 
   radiation-induced dysphagia and xerostomia. All patients were diagnosed with 
   stage III/IV squamous cell carcinoma. In all, 7 of 10 patients were percutaneous 
   endoscopic gastrostomy (PEG) tube dependent when they began acupuncture. Manual 
   acupuncture and electroacupuncture were used once a week. RESULTS: A total of 9 
   of 10 patients reported various degrees of subjective improvement in swallowing 
   functions, xerostomia, pain, and fatigue levels. Overall, 6 (86%) of 7 PEG 
   tube-dependent patients had their feeding tubes removed after acupuncture, with a 
   median duration of 114 days (range 49 to 368 days) post CRT. One typical case is 
   described in detail. CONCLUSIONS: A relatively short PEG tube duration and 
   reduced symptom severity following CRT were observed in these patients. Formal 
   clinical trials are required to determine the causality of the observations.
C1 Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. weidong_lu@dfci.harvard.edu
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD AUG 18
PY 2010
VL 9
IS 3
BP 284
EP 90
DI 10.1177/1534735410378856 
PG -194
WC Acupuncture Therapy; Adult; Aged; Carcinoma, Squamous Cell; drug therapy; Combined Modality Therapy; adverse effects; Deglutition; Deglutition Disorders; etiology; Enteral Nutrition; Female; Gastrostomy; Head and Neck Neoplasms; drug therapy; Humans; Intubation, Gastrointestinal; Male; Middle Aged
UT PubMed:20713374
PM 20713374
DA 2010-08-18
ER

PT J
AU Chen, X
   Mi, W
   Gao, T
   Ding, F
   Wang, W
AF Chen, Xuejiao
   Mi, Wenli
   Gao, Tianchi
   Ding, Fengfei
   Wang, Wei
TI Astrocytes in the rostral ventromedial medulla mediate the analgesic effect of 
SO Pain
LA English
DT Journal Article
AB Chemotherapy-induced peripheral neuropathic pain aggravates cancer survivors' 
   life burden. Electroacupuncture (EA) has exhibited promising analgesic effects on 
   neuropathic pain in previous studies. We investigated whether EA was effective in 
   a paclitaxel-induced neuropathic pain mouse model. We further explored the 
   functional role of astrocytes in the rostral ventromedial medulla (RVM), a 
   well-established pain modulation center, in the process of neuropathic pain as 
   well as the analgesic effect of EA. We found that paclitaxel induced mechanical 
   allodynia, astrocytic calcium signaling, and neuronal activation in the RVM and 
   spinal cord, which could be suppressed by EA treatment. Electroacupuncture 
   effectively alleviated paclitaxel-induced mechanical allodynia, and the effect 
   was attenuated by the chemogenetic activation of astrocytes in the RVM. In 
   addition, inhibiting astrocytic calcium activity by using either IP 3 R2 knockout 
   (IP 3 R2 KO) mice or microinjection of AAV-mediated hPMCA2 w/b into the RVM to 
   reduce non-IP 3 R2-dependent Ca 2+ signaling in astrocytes exhibited an analgesic 
   effect on neuropathic pain, which mimicked the EA effect. The current study 
   revealed the pivotal role of the RVM astrocytes in mediating the analgesic 
   effects of EA on chemotherapy-induced peripheral neuropathic pain.
C1 Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
   Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, Shanghai Key Laboratory ofAcupuncture Mechanism and Acupoint Function, State Key Laboratory of MedicalNeurobiology and MOE Frontiers Center for Brain Science, Institutes of BrainScience, Shanghai Medical College, Fudan University, Shanghai, China.
   Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, Shanghai Key Laboratory ofAcupuncture Mechanism and Acupoint Function, State Key Laboratory of MedicalNeurobiology and MOE Frontiers Center for Brain Science, Institutes of BrainScience, Shanghai Medical College, Fudan University, Shanghai, China.
   Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center forBrain Science, Institutes of Brain Science, Shanghai Medical College, FudanUniversity, Shanghai, China.
   Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
   Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong 
   Key Laboratory of Neurological Diseases of the Chinese Ministry of Education, School of Basic Medicine, Tongji Medical College, Huazhong University of Scienceand Technology, Wuhan, China.
NR 0
TC 0
SN 1872-662
EI 
J9 Pain
PD OCT 21
PY 2024
VL 166
IS 4
BP 916
EP 926
DI 10.1097/j.pain.0000000000003433 
PG 10
WC Animals; Astrocytes; physiology; Electroacupuncture; methods; Medulla Oblongata; Neuralgia; chemically induced; Mice; Disease Models, Animal; Male; Paclitaxel; toxicity; Hyperalgesia; therapy; Mice, Knockout; Mice, Inbred C57BL
UT PubMed:39432736
PM 39432736
DA 2024-10-21
ER

PT J
AU Zheng, J
   Yang, F
   Yuan, PW
   Fan, JJ
   Zheng, XH
   Zhu, R
   Li, YL
AF Zheng, Jie
   Yang, Feng
   Yuan, Pu-Wei
   Fan, Jing-Jie
   Zheng, Xiao-Hui
   Zhu, Rui
   Li, Yang-le
TI [Effect of electroacupuncture on the expression of Iba-1 in spinal dorsal horn 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Electroacupuncture; Hippocampus; Ionized calcium binding adapter molecule 1; Knee osteoarthritis; Pain; Spinal dorsal horn
AB OBJECTIVE: To observe the effect of electroacupuncture(EA) on pain-ralated 
   behaviors, morphology of hippocampus, concentrations of inflammatory cytokines 
   and expression of ionized calcium binding adapter molecule 1(Iba-1) in dorsal 
   horn of the spinal cord and the hippocampus, and brain-derived neurotrophic 
   factor (BDNF) in hippocampus of rats with knee osteoarthritis (KOA), so as to 
   explore the mechanism of EA in improving chronic pain of KOA. METHODS: Forty SD 
   rats were randomly divided into blank group, saline group, model group and EA 
   group, with 10 rats in each group. Monosodium iodoacetate(MIA, 80 mg/mL, 50 μL) 
   was injected into the left knee joint cavity of rats in the model group and EA 
   group to establish the chronic pain model of KOA, while the same volume of normal 
   saline was injected into the left knee joint cavity of rats in the saline group. 
   Rats in the EA group received EA stimulation(2 Hz/100 Hz, 1-2 mA) at left 
   "Yanglingquan"(GB34) and "Neixiyan"(EX-LE4) for 15 min, 14 d after MIA injection. 
   The treatment was given once daily, 5 d as 1 session and 2 sessions of treatment 
   were required. Methanical withdrawl threshold(MWT) and weight-bearing capacity 
   tests on left hind limbs were carried out 1 d before, 7 d，14 d, 20 d and 26 d 
   after MIA injection. At the 27(th) day, rats were sacrificed and HE staining was 
   used to observe the morphology of hippocampal CA1 area. Concentrations of 
   interleukin(IL)-1β and tumor necrosis factor(TNF)-α in the left L3-L5 spinal 
   dorsal horn and hippocampal CA1 area were detected by ELISA, the expressions of 
   Iba-1 in the spinal dorsal horn and hippo-campal CA1 area were detected by 
   immunofluorescence, and the expression of BDNF in left hippocampal CA1 area was 
   detected by Western blot. RESULTS: The HE staining results of the hippocampal CA1 
   area showed reduced number of neurons, unclear cell contour and boundary between 
   nucleus and cytoplasm, and nuclear pyknosis in the model group, which was 
   relatively milder in the EA group. Compared with the blank group, MWT and 
   weight-bearing capacity of rats' left hind limbs, and expression of BDNF protein 
   in hippocampal CA1 area were significantly decreased (P<0.01), while the contents 
   of IL-1β and TNF-α, the expression of Iba-1 in spinal dorsal horn and hippocampal 
   CA1 area were significantly increased (P<0.01) in the model group. In comparison 
   with the model group, MWT and weight-bearing capacity of rats' left hind limbs, 
   and protein expression of BDNF in hippocampal CA1 area were significantly 
   increased (P<0.01), while the contents of IL-1β and TNF-α, and the expression of 
   Iba-1 protein in spinal dorsal horn and hippocampal CA1 area were significantly 
   decreased after EA intervention(P<0.01). CONCLUSION: EA at GB34 and EX-LE4 can 
   alleviate the pain-related behaviors of KOA rats. The mechanism might be related 
   to the inhibition of inflammatory reaction mediated by microglia in spinal dorsal 
   horn and hippocampus, and the up-regulation of BDNF expression in hippocampus.
C1 Institution of Acupuncture-moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China
   Shaanxi Key Laboratory ofAcupuncture and Herbal Medicine, Xianyang 712046, Shaanxi Province.
   First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province.
   First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province.
   Institution of Acupuncture-moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China.
   Institution of Acupuncture-moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China.
   Institution of Acupuncture-moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China.
   Institution of Acupuncture-moxibustion and Tuina, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD MAY 30
PY 2023
VL 48
IS 5
BP 431
EP 7
DI 10.13702/j.1000-0607.20211398 
PG -424
WC Rats; Animals; Rats, Sprague-Dawley; Chronic Pain; Brain-Derived Neurotrophic Factor; metabolism; Osteoarthritis, Knee; genetics; Electroacupuncture; methods; Tumor Necrosis Factor-alpha; metabolism; Hippocampus; metabolism; Spinal Cord Dorsal Horn; metabolism
UT PubMed:37247855
PM 37247855
DA 2023-05-30
ER

PT J
AU Garcia, MK
   Cohen, L
   Guo, Y
   Zhou, Y
   You, B
   Chiang, J
   Orlowski, RZ
   Weber, D
   Shah, J
   Alexanian, R
   Thomas, S
   Romaguera, J
   Zhang, L
   Badillo, M
   Chen, Y
   Wei, Q
   Lee, R
   Delasalle, K
   Green, V
   Wang, M
AF Garcia, M Kay
   Cohen, Lorenzo
   Guo, Ying
   Zhou, Yuhong
   You, Bing
   Chiang, Joseph
   Orlowski, Robert Z
   Weber, Donna
   Shah, Jatin
   Alexanian, Raymond
   Thomas, Sheeba
   Romaguera, Jorge
   Zhang, Liang
   Badillo, Maria
   Chen, Yiming
   Wei, Qi
   Lee, Richard
   Delasalle, Kay
   Green, Vivian
   Wang, Michael
TI Electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy in 
SO Journal of hematology & oncology
LA English
DT Journal Article
AB BACKGROUND: This single-arm study evaluated feasibility, safety, and initial 
   efficacy of electroacupuncture for thalidomide/bortezomib-induced peripheral 
   neuropathy (PN) in cancer patients with multiple myeloma. METHODS: Patients with 
   neuropathy ≥ grade 2 received 20 acupuncture treatments over 9 weeks. RESULTS: 
   For the 19 evaluable patients, Functional Assessment of Cancer 
   Therapy/Gynecological Oncology Group-Neurotoxicity (FACT/GOG/NTX) mean (SD) 
   scores improved significantly between baseline and week 13 (20.8 [9.6] vs 13.2 
   [8.5], p = 0.0002). Moderate effect size differences began on week 4, with the 
   largest effect size differences found at week 9 for FACT/GOG/NTX scores, worst 
   pain in the last 24 hours, and pain severity (Cohen's d = 1.43, 1.19, and 1.08, 
   respectively) and continuing through week 13 (Cohen's d = 0.86, 0.88, and 0.90, 
   respectively). From baseline to week 13, additional significant improvements were 
   seen as follows: postural stability (1.0 [0.6] vs 0.8 [0.4], p = 0.02); coin test 
   (10.0 [7.4] vs 5.6 [1.9], p < 0.0001); button test (96.1 [144.4] vs 54.9 [47.3], 
   p < 0.0001); and walking test (21.6 [10.0] vs 17.2 [7.7], p = 0.0003). No 
   significant changes were seen with NCS. CONCLUSIONS: Acupuncture may help 
   patients experiencing thalidomide- or bortezomib-induced PN. Larger, randomized, 
   clinical trials are needed. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: 
   NCT00891618.
C1 Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 0429, Houston, Texas 77030, USA.miwang@mdanderson.org.
NR 0
TC 0
SN 1756-872
EI 
J9 J Hematol Oncol
PD JUN 3
PY 2014
VL 7
IS 
BP 41
EP 41
DI 10.1186/1756-8722-7-41 
PG 0
WC Aged; Antineoplastic Combined Chemotherapy Protocols; adverse effects; Boronic Acids; administration & dosage; Bortezomib; Electroacupuncture; methods; Feasibility Studies; Female; Humans; Male; Middle Aged; Multiple Myeloma; drug therapy; Pain Measurement; methods; Peripheral Nervous System Diseases; chemically induced; Pyrazines; administration & dosage; Thalidomide; administration & dosage; Time Factors; Treatment Outcome
UT PubMed:24886772
PM 24886772
DA 2014-06-03
ER

PT J
AU Rossi, E
   Vita, A
   Baccetti, S
   Di, Stefano M
   Voller, F
   Zanobini, A
AF Rossi, Elio
   Vita, Alessandra
   Baccetti, Sonia
   Di Stefano, Mariella
   Voller, Fabio
   Zanobini, Alberto
TI Complementary and alternative medicine for cancer patients: results of the EPAAC 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
AB BACKGROUND: The Region of Tuscany Health Department was included as an associated 
   member in WP7 "Healthcare" of the European Partnership for Action Against Cancer 
   (EPAAC), initiated by the EU Commission in 2009. AIMS: The principal aim was to 
   map centres across Europe prioritizing those that provide public health services 
   and operating within the national health system in integrative oncology (IO). 
   METHODS: A cross-sectional descriptive survey design was used to collect data. A 
   questionnaire was elaborated concerning integrative oncology therapies to be 
   administered to all the national health system oncology centres or hospitals in 
   each European country. These institutes were identified by convenience sampling, 
   searching on oncology websites and forums. The official websites of these 
   structures were analysed to obtain more information about their activities and 
   contacts. RESULTS: Information was received from 123 (52.1 %) out of the 236 
   centres contacted until 31 December 2013. Forty-seven out of 99 responding 
   centres meeting inclusion criteria (47.5 %) provided integrative oncology 
   treatments, 24 from Italy and 23 from other European countries. The number of 
   patients seen per year was on average 301.2 ± 337. Among the centres providing 
   these kinds of therapies, 33 (70.2 %) use fixed protocols and 35 (74.5 %) use 
   systems for the evaluation of results. Thirty-two centres (68.1 %) had research 
   in progress or carried out until the deadline of the survey. The complementary 
   and alternative medicines (CAMs) more frequently provided to cancer patients were 
   acupuncture 26 (55.3 %), homeopathy 19 (40.4 %), herbal medicine 18 (38.3 %) and 
   traditional Chinese medicine 17 (36.2 %); anthroposophic medicine 10 (21.3 %); 
   homotoxicology 6 (12.8 %); and other therapies 30 (63.8 %). Treatments are mainly 
   directed to reduce adverse reactions to chemo-radiotherapy (23.9 %), in 
   particular nausea and vomiting (13.4 %) and leucopenia (5 %). The CAMs were also 
   used to reduce pain and fatigue (10.9 %), to reduce side effects of iatrogenic 
   menopause (8.8 %) and to improve anxiety and depression (5.9 %), gastrointestinal 
   disorders (5 %), sleep disturbances and neuropathy (3.8 %). CONCLUSIONS: Mapping 
   of the centres across Europe is an essential step in the process of creating a 
   European network of centres, experts and professionals constantly engaged in the 
   field of integrative oncology, in order to increase, share and disseminate the 
   knowledge in this field and provide evidence-based practice.
C1 Department of Research, Innovation and Human Resources, Regional Health Ministry of Region of Tuscany (Italy), Tuscan Network for Integrative Medicine, via T.Alderotti 26 N - 50100, Florence, Italy,retemedicinaintegrata@regione.toscana.it.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD DEC 5
PY 2014
VL 23
IS 6
BP 1795
EP 806
DI 10.1007/s00520-014-2517-4 
PG -989
WC Acupuncture Therapy; statistics & numerical data; Anxiety; therapy; Complementary Therapies; statistics & numerical data; Cross-Sectional Studies; Delivery of Health Care; methods; Ethnicity; Europe; Female; Humans; Male; Medicine, Chinese Traditional; Neoplasms; therapy; Pain; Pain Management; Phytotherapy; statistics & numerical data; Surveys and Questionnaires; United States
UT PubMed:25471177
PM 25471177
DA 2014-12-05
ER

PT J
AU Jiang, L
   Deng, Z
   Zhang, H
   Li, Y
   Wang, T
   Xie, W
AF Jiang, Li
   Deng, Zhaoxia
   Zhang, Hongcai
   Li, Yuan
   Wang, Tingting
   Xie, Wen
TI Acupoint for angina pectoris: A protocol for systematic review and meta-analysis.
SO Medicine
LA English
DT Journal Article
AB INTRODUCTION: Patients with angina pectoris (AP) often experience heavy 
   psychological distress, especially anxiety and depression, which results in 
   poorer quality of life, shorter survival time. Acupoint therapies, including 
   massage, acupuncture, acupoints injection, acupressure, and moxibustion, showed 
   clinical and long-lasting benefits for AP, but the efficiency of acupoint 
   therapies was poorly evaluated. The current review is attempted to evaluate the 
   efficacy and safety of the different acupoint-based therapies for AP. METHODS AND 
   ANALYSIS: A literature search will be conducted in MEDLINE, EMBASE, Web of 
   Science, Cochrane Library, Web of Science, PubMed, Science Direct, Wan Fang Data 
   Knowledge Service Platform, Chinese Biomedical Literature Database (CBM), Chinese 
   Scientific Journal Database (VIP database), and China National Knowledge 
   Infrastructure (CNKI). Observational studies regarding the association between 
   liver cancer and depression and anxiety written in English or Chinese will be 
   included. Study inclusion, data extraction, and quality assessment will be 
   performed independently by 2 reviewers. We will use RevMan V.5.0 and STATA V.12.0 
   software for statistical analysis. The I2 test will be used to identify the 
   extent of heterogeneity. Publication bias will be assessed by generating a funnel 
   plot and performing the Begg and Egger test. The quality of the systematic review 
   will be evaluated using the Measurement Tool to Assess Systematic Reviews 
   (AMSTAR) and Grading of Recommendations Assessment Development and Evaluation 
   (GRADE) criteria. With the permitted numeric data, we will carry out a 
   meta-analysis. RESULTS: This study will provide a high-quality synthesis of pain 
   VAS and functional disability or the quality of life, the success treatment rate, 
   the recurrent rate and the complications rate to assess the effectiveness and 
   safety of acupoint for AP patients. This systematic review will provide evidence 
   to judge whether acupoint is an effective intervention for patients with AP. 
   CONCLUSION: This systematic review and meta-analysis will provide evidence to 
   judge whether acupoint is an effective intervention for patients with AP and 
   provide evidence for designing early targeted interventions for high-risk 
   survivors that can attenuate negative reactions. PROSPERO REGISTRATION NUMBER: 
   10.17605/OSF.IO/VNXWE.
C1 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province.
   Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province.
   Chengdu University of Traditional Chinese Medicine, PR China.
   Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province.
   Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province.
   Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD FEB 7
PY 2021
VL 100
IS 3
BP e24080
EP e24080
DI 10.1097/MD.0000000000024080 
PG 1
WC Acupuncture Points; Angina Pectoris; therapy; Humans; Meta-Analysis as Topic; Systematic Reviews as Topic
UT PubMed:33546012
PM 33546012
DA 2021-02-07
ER

PT J
AU Hsiao, IH
   Yen, CM
   Hsu, HC
   Liao, HY
   Lin, YW
AF Hsiao, I-Han
   Yen, Chia-Ming
   Hsu, Hsin-Cheng
   Liao, Hsien-Yin
   Lin, Yi-Wen
TI Chemogenetics Modulation of Electroacupuncture Analgesia in Mice Spared Nerve 
SO International journal of molecular sciences
LA English
DT Journal Article
DE SSC; TRPV1; chemogenetics; electroacupuncture; neuropathic pain; pERK
AB Neuropathic pain, which is initiated by a malfunction of the somatosensory cortex 
   system, elicits inflammation and simultaneously activates glial cells that 
   initiate neuroinflammation. Electroacupuncture (EA) has been shown to have 
   therapeutic effects for neuropathic pain, although with uncertain mechanisms. We 
   suggest that EA can reliably cure neuropathic disease through anti-inflammation 
   and transient receptor potential V1 (TRPV1) signaling pathways from the 
   peripheral to the central nervous system. To explore this, we used EA to treat 
   the mice spared nerve injury (SNI) model and explore the underlying molecular 
   mechanisms through novel chemogenetics techniques. Both mechanical and thermal 
   pain were found in SNI mice at four weeks (mechanical: 3.23 ± 0.29 g; thermal: 
   4.9 ± 0.14 s). Mechanical hyperalgesia was partially attenuated by 2 Hz EA 
   (mechanical: 4.05 ± 0.19 g), and thermal hyperalgesia was fully reduced (thermal: 
   6.22 ± 0.26 s) but not with sham EA (mechanical: 3.13 ± 0.23 g; thermal: 4.58 ± 
   0.37 s), suggesting EA's specificity. In addition, animals with Trpv1 deletion 
   showed partial mechanical hyperalgesia and no significant induction of thermal 
   hyperalgesia in neuropathic pain mice (mechanical: 4.43 ± 0.26 g; thermal: 6.24 ± 
   0.09 s). Moreover, we found increased levels of inflammatory factors such as 
   interleukin-1 beta (IL1-β), IL-3, IL-6, IL-12, IL-17, tumor necrosis factor 
   alpha, and interferon gamma after SNI modeling, which decreased in the EA and 
   Trpv1(-/-) groups rather than the sham group. Western blot and immunofluorescence 
   analysis showed similar tendencies in the dorsal root ganglion, spinal cord 
   dorsal horn, somatosensory cortex (SSC), and anterior cingulate cortex (ACC). In 
   addition, a novel chemogenetics method was used to precisely inhibit SSC to ACC 
   activity, which showed an analgesic effect through the TRPV1 pathway. In summary, 
   our findings indicate a novel mechanism underlying neuropathic pain as a 
   beneficial target for neuropathic pain.
C1 School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan.
   Department of Neurosurgery, China Medical University Hospital, Taichung 40402, 
   Department of Anesthesiology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 42743, Taiwan.
   School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 97004, 
   School of Post-Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
   Department of Traditional Chinese Medicine, China Medical University Hsinchu 
   School of Post-Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
   Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
   Chinese Medicine Research Center, China Medical University, Taichung 40402, 
NR 0
TC 0
SN 1422-006
EI 
J9 Int J Mol Sci
PD FEB 10
PY 2024
VL 25
IS 3
BP 
EP 
DI 10.3390/ijms25031771 
PG 0
WC Rats; Mice; Animals; Hyperalgesia; etiology; Electroacupuncture; methods; Rats, Sprague-Dawley; Spinal Cord; metabolism; Neuralgia; etiology; Spinal Cord Dorsal Horn; metabolism; Signal Transduction; Trauma, Nervous System; metabolism; TRPV Cation Channels; genetics
UT PubMed:38339048
PM 38339048
DA 2024-02-10
ER

PT J
AU Tai, JB
   Hong, L
   Ma, ME
   Xu, J
   Fang, JQ
   Jiang, YQ
AF Tai, Jia-Bin
   Hong, Liang
   Ma, Meng-En
   Xu, Jia
   Fang, Jian-Qiao
   Jiang, Yi-Qian
TI Evaluation of therapeutic effect of transcutaneous electrical acupoint 
SO Annals of palliative medicine
LA English
DT Journal Article
DE Transcutaneous acupoint electrical stimulation; cancerous pain; clinical research; immunity; tumor
AB BACKGROUND: This study aimed to observe the effect of transcutaneous electrical 
   acupoint stimulation (TEAS) on bone metastasis pain, anxiety and immune function 
   in cancer patients. METHODS: A total of 127 patients with bone metastasis pain 
   from malignant tumors were treated with TEAS or drugs. The TEAS group comprised 
   of 62 patients, while the drug control group comprised of 65 patients. The 
   differences in general indexes, baseline pain and anxiety between these two 
   groups were not statistically significant. RESULTS: Compared with those before 
   treatment, the visual analog scale (VAS) scores of patients in the TEAS group and 
   drug control group decreased after treatment, and the differences were 
   statistically significant. The degrees of pain relief after treatment were 
   similar between the two groups. Anxiety improved in both the TEAS group and drug 
   control group, and the difference between these two groups was not statistically 
   significant. The differences in immune indexes, B cell and CD8 between the TEAS 
   group and drug control group were statistically significant. TEAS treatment could 
   improve the declining trend of CD8 in patients. CONCLUSIONS: TEAS treatment and 
   drug treatment can effectively alleviate mild to moderate pain in patients, and 
   the efficacy of these two groups is similar. The treatment for moderate and 
   severe pain needs to be combined with drug treatment to achieve a control effect. 
   TEAS can improve the anxiety and immune function of patients, and prevent the 
   decrease in B cells and CD8 in patients treated with drugs alone.
C1 Internal Medicine-Oncology, Xiaoshan First Hospital Affiliated to Medical College of Hangzhou Normal University, Hangzhou, China.
   Internal Medicine-Oncology, Xiaoshan First Hospital Affiliated to Medical College of Hangzhou Normal University, Hangzhou, China.
   Internal Medicine-Oncology, Xiaoshan First Hospital Affiliated to Medical College of Hangzhou Normal University, Hangzhou, China.
   Internal Medicine-Oncology, Xiaoshan First Hospital Affiliated to Medical College of Hangzhou Normal University, Hangzhou, China.
   Zhejiang University of Traditional Chinese Medicine, Hangzhou, China.
   Internal Medicine-Oncology, Xiaoshan First Hospital Affiliated to Medical College of Hangzhou Normal University, Hangzhou, China. yiqian9988@163.com.
NR 0
TC 0
SN 2224-583
EI 
J9 Ann Palliat Med
PD SEP 22
PY 2020
VL 9
IS 5
BP 2538
EP 2544
DI 10.21037/apm-19-434 
PG 6
WC Acupuncture Points; Cancer Pain; therapy; Humans; Immunity; Pain Management; Transcutaneous Electric Nerve Stimulation
UT PubMed:32954744
PM 32954744
DA 2020-09-22
ER

PT J
AU Yang, J
   Lan, X
   Cai, Q
   Lu, Z
   Wang, Y
AF Yang, Jiaxiang
   Lan, Xiangdong
   Cai, Qingcheng
   Lu, Ziheng
   Wang, Yanjun
TI Exercise Plus Acupuncture on Consensus Acupoints Versus Acupoints Selected by the 
SO Alternative therapies in health and medicine
LA English
DT Journal Article
AB CONTEXT: Knee osteoarthritis (KOA) is a degenerative disorder that significantly 
   affects patients' quality of life. Acupuncture and exercise are the most popular 
   treatments currently. The outcomes for acupuncture for KOA, however, are 
   controversial, with some researchers finding that the addition of acupuncture to 
   exercise therapy provided no additional improvement in pain scores. OBJECTIVE: 
   The study intended to evaluate the therapeutic effects for KOA of exercise in 
   combination with acupuncture on acupoints selected using the Traditional Chinse 
   Medicine (TCM) theory of Equal Impact on Tendons, Bones, and Muscles (EITBM) in 
   comparison with that of acupoints selected using classical consensus for the 
   treatment. DESIGN: The research team performed a randomized controlled trial. 
   SETTING: The study took place in the Department of Acupuncture and Moxibustion at 
   the First Affiliated Hospital of Hebei University of Chinese Medicine in 
   Shijiazhuang, Hebei, China. PARTICIPANTS: Participants were 70 patients with KOA 
   who visited the hospital between December 2020 and February 2021. INTERVENTION: 
   Participants in both group received acupuncture plus exercise therapy. The 
   research team randomly assigned participants to one of two groups: (1) 35 to the 
   intervention group, which received acupuncture using acupoints selected using 
   EITBM, and (2) 35 to the control group, which received acupuncture using the 
   classical consensus acupoints. Both groups performed a 25-min session of 
   acupuncture three times weekly for 4 weeks, with the exercise therapy following 
   the acupuncture each time. OUTCOME MEASURES: The research team assessed clinical 
   efficacy at baseline and postintervention. The primary outcome measures included 
   assessments: (1) of knee joint pain using a visual analog scale (VAS), (2) of 
   knee joint pain, flexibility, and function using the Western Ontario and McMaster 
   University Osteoarthritis Index (WOMAC) pain subscale; and (3) joint range of 
   motion (ROM). The secondary outcome measures included measurement of serum levels 
   of interleukin-1 beta (IL-1ß), tumor necrosis factor alpha (TNF-α), and matrix 
   metalloproteinase-13 (MMP-13) using enzyme-linked immunosorbent assays (ELISA). 
   RESULTS: The VAS and WOMAC scores significantly decreased for both groups between 
   baseline and postintervention, and the intervention group's decrease was 
   significantly greater than that of the control group. The ROM of knee flexion was 
   significantly higher in both groups postintervention than at baseline, and the 
   intervention group's increase was significantly higher than that of the control 
   group. The serum IL-1ß, TNF-α, and MMP-13 also significantly decreased 
   postintervention in both groups, and the intervention group's levels were 
   significantly lower than those of the control group. The total effective rate was 
   94.1% in the intervention group, 32 out of 34 participants, and 75.8% in the 
   control group, 25 out of 33 participants, which was significantly different. 
   CONCLUSIONS: Acupuncture, in combination with exercise, can relieve symptoms, 
   improve joint function, and reduce pro-inflammatory cytokines (IL-1ß and TNF-a) 
   as well as MMP-13 for patients with KOA. The outcomes for acupuncture using EITBM 
   acupoints were significantly better than those of the acupoints selected using 
   classical consensus.
NR 0
TC 0
SN 
EI 1078-679
J9 Altern Ther Health Med
PD APR 14
PY 2023
VL 29
IS 5
BP 262
EP 267
DI 
PG 5
WC Humans; Osteoarthritis, Knee; therapy; Matrix Metalloproteinase 13; Acupuncture Points; Tumor Necrosis Factor-alpha; Consensus; Quality of Life; Acupuncture Therapy; Treatment Outcome; Pain; Tendons; Muscles; Arthralgia
UT PubMed:37052974
PM 37052974
DA 2023-04-14
ER

PT J
AU Oberoi, DV
   Longo, CJ
   Reed, EN
   Landmann, J
   Piedalue, KL
   Carlson, LE
AF Oberoi, Devesh V
   Longo, Christopher J
   Reed, Erica Nicole
   Landmann, Jessa
   Piedalue, Katherine-Ann Laura
   Carlson, Linda E
TI Cost-Utility of Group Versus Individual Acupuncture for Cancer-Related Pain Using 
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
DE acupuncture; cost–utility analysis; group acupuncture; oncology; out-of-pocket costs for cancer care; quality of life
AB Introduction: Individual acupuncture (AP) is the gold standard method of AP 
   delivery for cancer-related pain; however, costs can be prohibitive. Group AP 
   allows four to six patients to be treated in a single session. This study sought 
   to examine the cost-utility of group AP compared with individual AP from a 
   patient perspective. Materials and Methods: Effectiveness and cost data from a 
   noninferiority randomized trial of group versus individual AP for cancer-related 
   pain were used. In the trial, 74 patients were randomly assigned to individual or 
   group AP treatments twice per week for 6 weeks. The EuroQol five-dimension five 
   level questionnaire (EQ-5D-5L) was used to assess health-related quality of life, 
   and the EQ-5D Utility Index was used as a composite measure constituted of five 
   domains (mobility, self-care, usual activities, anxiety-depression, and 
   pain-discomfort). Linear mixed models were used to compare the change in EQ-5D-5L 
   states pre-post intervention between the two arms. A cost-utility analysis was 
   performed in terms of the incremental costs per additional quality-adjusted life 
   year (QALY) gained. Results: Group AP participants experienced more significant 
   relief in the pain-discomfort subscale of the EQ-5D-5L measure compared with 
   individual AP participants (group × time, F = 6.18; p = 0.02). The effect size on 
   pain-discomfort for group AP (d = 0.80) was higher than that of individual AP 
   (d = 0.34). There were no significant differences between the two study arms for 
   other subscales of the EQ-5D-5L over time. QALYs at 6 weeks were slightly higher 
   for group AP (0.020) compared with individual AP (0.007) leading to an 
   incremental QALY gained by the group arm of 0.013, but this difference was not 
   statistically significant (p = 0.07). The cost of delivering AP treatment for the 
   group arm over 6 weeks ($201.25) was nearly half of the individual arm ($400). 
   Conclusions: Group AP was superior to individual AP in cancer patients. These 
   findings have implications for the use of group AP in low-resource settings and 
   in health care systems where AP for cancer patients is not covered by public 
   health insurance. ClinicalTrials.gov (NCT03641222). Registered July 10, 
   2018-Retrospectively registered, 
   https://clinicaltrials.gov/ct2/show/study/NCT03641222.
C1 Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
   Department of Psychosocial Oncology, Cancer Control Alberta, Holy Cross Centre 
   The DeGroote School of Business, McMaster University, Hamilton, Canada.
   Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
   Vive Integrative Health Group, Calgary, Canada.
   Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
   Department of Psychosocial Oncology, Cancer Control Alberta, Holy Cross Centre 
   Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
   Department of Psychosocial Oncology, Cancer Control Alberta, Holy Cross Centre 
NR 0
TC 0
SN 1557-770
EI 
J9 J Altern Complement Med
PD APR 28
PY 2021
VL 27
IS 5
BP 390
EP 397
DI 10.1089/acm.2020.0386 
PG 7
WC Acupuncture Therapy; Adult; Cancer Pain; therapy; Cost-Benefit Analysis; Female; Health Expenditures; Humans; Male; Middle Aged; Quality-Adjusted Life Years; Shared Medical Appointments
UT PubMed:33904784
PM 33904784
DA 2021-04-28
ER

PT J
AU Zhang, M
   Guan, L
AF Zhang, Mengxue
   Guan, Ling
TI [Impact on neutrophil-to-lymphocyte ratio and quality of life in the patients of 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB OBJECTIVE: To explore the impact on neutrophil-to-lymphocyte ratio (NLR) and the 
   quality of life (QOL) in the patients of non-small-cell lung cancer (NSCLC) 
   treated with wheat-size moxibustion therapy. METHODS: Seventy patients of NSCLC 
   were randomized into an observation group and a control group, 35 cases in each 
   one. Finally, 33 cases were participated in the observation group and 32 cases in 
   the control group for statistical analysis. In the observation group, Zusanli (ST 
   36) and Feishu (BL 13) were selected for grain-size moxibustion, 9 moxa cones on 
   each acupoint, once a day. There was the follow-up visit without any treatment 
   applied in the control group. The trial lasted for 6 weeks. The changes in NLR 
   and the QOL score before and after treatment were observed in the patients of the 
   two groups and the differences were compared between the two groups. RESULTS: 
   Compared with the condition before treatment, in the observation group, NLR was 
   reduced apparently (P< 0.05), the general health state/life quality field, 
   physical functioning, emotional functioning, cognitive functioning, fatigue, 
   pain, short breath, insomnia and anorexia were improved apparently (all P < 
   0.05). In the control group, the differences were not significant in NLR, the 
   general health states/life quality field, physical functioning, emotional 
   functioning, cognitive functioning, role functioning, social functioning, 
   fatigue, pain, short breath, insomnia and anorexia before and after treatment 
   (all P > 0.05). In comparison of the two groups, NLR was reduced apparently in 
   the observation group as compared with that in the control group after treatment 
   (P < 0.05). The scores of the general health state/life quality field, physical 
   functioning, emotional functioning and cognitive functioning were increased 
   apparently as compared with those in the control group after treatment (all P < 
   0.05). The scores of fatigue, pain, short breath, insomnia and anorexia in the 
   observation group were reduced apparently as compared with those in the control 
   group after treatment (all P < 0.05). CONCLUSION: The wheat-size moxibustion 
   therapy reduces NLR and improves the immune function and quality of life in the 
   patients of NSCLC.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUN 29
PY 2016
VL 36
IS 4
BP 342
EP 6
DI 
PG -336
WC Adult; Aged; Carcinoma, Non-Small-Cell Lung; immunology; Female; Humans; Lung Neoplasms; immunology; Lymphocytes; immunology; Male; Middle Aged; Moxibustion; Neutrophils; immunology; Quality of Life
UT PubMed:27352487
PM 27352487
DA 2016-06-29
ER

PT J
AU Jung, M
   Rein, N
   Fuchs, B
AF Jung, M
   Rein, N
   Fuchs, B
TI [Physical Therapy for Chemotherapy-induced Peripheral Neuropathy in Pediatric 
SO Klinische Padiatrie
LA ger
DT Journal Article
AB Background: Chemotherapy-induced peripheral neuropathy is a frequent side-effect 
   of drugs that are used in the treatment of cancer. Affected individuals can 
   suffer from motor, sensory or autonomy nerve damage. Further medication is used 
   for the treatment of CIPN which can cause further side-effects. Patients should 
   be offered physical therapy treatment to relieve the symptoms. Objective: The aim 
   of this article is to give an overview of available literature investigating 
   physical therapy in CIPN in pediatric oncology. Methods: To determine relevant 
   literature, a systematic review was conducted in the databases CINAHL, The 
   Cochrane Library, ERIC, MEDPILOT, PEDro, PsycARTICLES, PsycINFO, PubMed and 
   DIMDI. Besides the methodological quality of the identified literature is 
   supposed to be reviewed. Results: There is no current literature regarding the 
   subject of this article, so no evaluation of the quality could be carried out. 
   Although several publications concerning adults could be identified and transfer 
   could be established for pediatrics. Conclusion: Acupuncture appeared to be 
   effective in the treatment of CIPN in adults. Good results appeared especially 
   regarding pain. Sensorimotor training, balance training, electrotherapy and 
   alternative methods like Reiki and Yoga showed good results for patients 
   symptoms. These treatment methods give a future prospect how CIPN in children can 
   be treated successfully - but further pediatric research is necessary.
C1 School of Therapy and Social Works, Hochschule Fresenius gGmbH, Idstein.
   Medical School, Hochschule Fresenius gGmbH, Idstein.
   School of Therapy and Social Works, Hochschule Fresenius gGmbH, Idstein.
NR 0
TC 0
SN 1439-382
EI 
J9 Klin Padiatr
PD NOV 16
PY 2016
VL 228
IS 6-07
BP 313
EP 318
DI 10.1055/s-0042-111692 
PG 5
WC Acupuncture Therapy; Antineoplastic Agents; adverse effects; Child; Humans; Neoplasms; drug therapy; Peripheral Nervous System Diseases; chemically induced; Physical Therapy Modalities; Treatment Outcome
UT PubMed:27846661
PM 27846661
DA 2016-11-16
ER

PT J
AU Kwan, YH
   Fong, W
   Ang, XL
   Tan, CS
   Tai, BC
   Huang, Y
   Bilger, M
   Phang, JK
   Tan, HC
   Lee, JV
   Sun, L
   Tan, CT
   Dong, BQ
   Koh, HL
   Leung, YY
   Lui, NL
   Yeo, SI
   Ng, SC
   Fong, KY
   Thumboo, J
   Østbye, T
AF Kwan, Yu Heng
   Fong, Warren
   Ang, Xiang Ling
   Tan, Chuen Seng
   Tai, Bee Choo
   Huang, Youyi
   Bilger, Marcel
   Phang, Jie Kie
   Tan, Hui Chin
   Lee, Jia Ven
   Sun, Limin
   Tan, Choy Tip
   Dong, Bao Qiang
   Koh, Hwee Ling
   Leung, Ying Ying
   Lui, Nai Lee
   Yeo, Siaw Ing
   Ng, Swee Cheng
   Fong, Kok Yong
   Thumboo, Julian
   Østbye, Truls
TI Traditional Chinese medicine (TCM) collaborative care for patients with axial 
SO Trials
LA English
DT Journal Article
AB BACKGROUND: Axial spondyloarthritis (AxSpA) is a chronic disease which results in 
   fatigue, pain, and reduced quality of life (QoL). Traditional Chinese medicine 
   (TCM), especially acupuncture, has shown promise in managing pain. Although a TCM 
   collaborative model of care (TCMCMC) has been studied in cancer, there are no 
   randomized controlled trials investigating TCM in AxSpA. Therefore, we will 
   conduct a pragmatic trial to determine the clinical effectiveness, safety, and 
   cost-effectiveness of TCMCMC for patients with AxSpA. We define TCMCMC as 
   standard TCM history taking and physical examination, acupuncture, and TCM 
   non-pharmacological advice and communications with rheumatologists in addition to 
   usual rheumatologic care. The purpose of this paper is to describe the rationale 
   for and methodology of this trial. METHODS/DESIGN: This pragmatic randomized 
   controlled trial will recruit 160 patients who are diagnosed with AxSpA and have 
   inadequate response to non-steroidal anti-inflammatory drugs (NSAIDs). Simple 
   randomization to usual rheumatologic care or the intervention (TCMCMC) with a 1:1 
   allocation ratio will be used. Ten 30-min acupuncture sessions will be provided 
   to patients assigned to the TCMCMC arm. All participants will continue to receive 
   usual rheumatologic care. The primary endpoint - spinal pain - will be evaluated 
   at week 6. Secondary endpoints include clinical, quality of life, and economic 
   outcome measures. Patients will be followed up for up to 52 weeks, and adverse 
   events will be documented. DISCUSSION: This trial may provide evidence regarding 
   the clinical effectiveness, safety, and cost-effectiveness of a TCMCMC for 
   patients with AxSpA. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03420404 . 
   Registered on 14 February 2018.
C1 Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
   Department of Rheumatology and Immunology, Singapore General Hospital, Academia Building, Level 4, 20 College Road, Singapore, 169856, Singapore.
   Duke-NUS Medical School, Singapore, Singapore.
   Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
   Singapore Thong Chai Medical Institution, Singapore, Singapore.
   Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
   Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
   Internal Medicine Residency, SingHealth, Singapore, Singapore.
   Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
   Department of Rheumatology and Immunology, Singapore General Hospital, Academia Building, Level 4, 20 College Road, Singapore, 169856, Singapore.
   Singapore Thong Chai Medical Institution, Singapore, Singapore.
   Singapore Thong Chai Medical Institution, Singapore, Singapore.
   Singapore Thong Chai Medical Institution, Singapore, Singapore.
   Singapore Thong Chai Medical Institution, Singapore, Singapore.
   Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, People's Republic of China.
   Department of Pharmacy, National University of Singapore, Singapore, Singapore.
   Department of Rheumatology and Immunology, Singapore General Hospital, Academia Building, Level 4, 20 College Road, Singapore, 169856, Singapore.
   Duke-NUS Medical School, Singapore, Singapore.
   Department of Rheumatology and Immunology, Singapore General Hospital, Academia Building, Level 4, 20 College Road, Singapore, 169856, Singapore.
   Department of Rheumatology and Immunology, Singapore General Hospital, Academia Building, Level 4, 20 College Road, Singapore, 169856, Singapore.
   Department of Rheumatology and Immunology, Singapore General Hospital, Academia Building, Level 4, 20 College Road, Singapore, 169856, Singapore.
   Department of Rheumatology and Immunology, Singapore General Hospital, Academia Building, Level 4, 20 College Road, Singapore, 169856, Singapore.
   Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore. julian.thumboo@singhealth.com.sg.
   Department of Rheumatology and Immunology, Singapore General Hospital, Academia 
   Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
NR 0
TC 0
SN 1745-621
EI 
J9 Trials
PD JAN 16
PY 2019
VL 20
IS 1
BP 46
EP 46
DI 10.1186/s13063-018-3117-2 
PG 0
WC Acupuncture Therapy; Back Pain; diagnosis; Cost-Benefit Analysis; Female; Health Care Costs; Humans; Interdisciplinary Communication; Male; Medical History Taking; Medicine, Chinese Traditional; adverse effects; Patient Care Team; Physical Examination; Pragmatic Clinical Trials as Topic; Rheumatologists; economics; Singapore; Spondylarthropathies; diagnosis; Time Factors; Treatment Outcome
UT PubMed:30642381
PM 30642381
DA 2019-01-16
ER

PT J
AU Fiorini, FR
   Santoro, R
   Cristofaro, G
   Buongiorno, A
   Mannelli, G
   Picconi, M
   Gallo, O
AF Fiorini, F R
   Santoro, R
   Cristofaro, G
   Buongiorno, A
   Mannelli, G
   Picconi, M
   Gallo, O
TI Potential use of acupuncture in the treatment of first bite syndrome.
SO American journal of otolaryngology
LA English
DT Journal Article
AB OBJECTIVES: First bite syndrome (FBS) is an early postoperative pain syndrome 
   characterized by the sudden onset of pain in the parotid region at the first bite 
   of each meal. The etiology is not certain, hence a standardized therapy does not 
   exist. METHODS: A 50-year old woman referred to us complaining of a swelling in 
   the right parotid region. Fine-needle aspiration biopsy (FNAB) was diagnostic for 
   pleomorphus adenoma of the deep lobe of the parotid gland. A 50-year old man 
   presented with a mass in the right side of the neck, FNAB was diagnostic for 
   parapharyngeal space neurinoma. The first patient was submitted to total 
   parotidectomy with facial nerve preservation, the second to extracapsular 
   dissection of the tumor. A week after surgery both patients developed FBS. A 
   qualitative/quantitative description of pain was obtained by means of a 
   self-coded questionnaire. The score ranges from 8 to 44, corresponding to the 
   lowest and the highest discomfort possible, respectively. Acupuncture was used to 
   treat these 2 patients. The treatment protocol comprised 6 sessions, one per 
   week, lasting 30 minutes each. RESULTS: Our questionnaire was administered before 
   and after treatment and the score dropped from 33 to 25 in the female, from 30 to 
   15 in the male patient. CONCLUSION: FBS is a complication of upper cervical 
   surgery with a high morbidity rate. We describe the first two cases of FBS that 
   were successfully treated with acupuncture in our ENT department. We believe that 
   this procedure may represent a valid therapeutic alternative in the future.
C1 First Clinic of Otorhinolaryngology, Deparment of Surgery and Translational Medicine, University of Florence, Italy. 
   First Clinic of Otorhinolaryngology, Deparment of Surgery and Translational Medicine, University of Florence, Italy.
   First Clinic of Otorhinolaryngology, Deparment of Surgery and Translational Medicine, University of Florence, Italy.
   First Clinic of Otorhinolaryngology, Deparment of Surgery and Translational Medicine, University of Florence, Italy.
   First Clinic of Otorhinolaryngology, Deparment of Surgery and Translational Medicine, University of Florence, Italy.
   "Sinergie" private practice and "Panakeia", School of Naturopathy, Florence, Italy.
   First Clinic of Otorhinolaryngology, Deparment of Surgery and Translational Medicine, University of Florence, Italy.
EM rancescaromanafiorini@gmail.com
NR 0
TC 0
SN 1532-818
EI 
J9 Am J Otolaryngol
PD MAR 19
PY 2015
VL 36
IS 3
BP 484
EP 7
DI 10.1016/j.amjoto.2015.01.023 
PG -477
WC Acupuncture Therapy; Adenoma, Pleomorphic; surgery; Female; Humans; Male; Mastication; Middle Aged; Neurilemmoma; surgery; Pain; diagnosis; Parotid Neoplasms; surgery; Postoperative Complications; Syndrome
UT PubMed:25783766
PM 25783766
DA 2015-03-19
ER

PT J
AU Liao, CC
   Lin, CL
   Tsai, FJ
   Chien, CH
   Li, JM
AF Liao, Chung-Chih
   Lin, Cheng-Li
   Tsai, Fuu-Jen
   Chien, Chi-Hsien
   Li, Jung-Miao
TI Acupuncture's long-term impact on depression prevention in primary dysmenorrhea: 
SO Journal of affective disorders
LA English
DT Journal Article
DE Acupuncture; Bioinformatics; Depression; Molecular mechanisms; Prevention; Primary dysmenorrhea
AB BACKGROUND: Primary dysmenorrhea (PD) is a common gynecological condition causing 
   depression. Acupuncture is an effective option for PD management but its effects 
   on PD-associated depression remain unclear. METHODS: A retrospective cohort study 
   involving 35,099 propensity score-matched pairs of acupuncture users and 
   non-users with PD was conducted using data from Taiwan's Longitudinal Generation 
   Tracking Database 2000. Cox proportional hazard models were used to estimate 
   depression risk, and bioinformatics analyses were performed to uncover underlying 
   molecular mechanisms. RESULTS: The risk of developing depression was reduced by 
   64 % in acupuncture users compared with non-acupuncture users during the 19-year 
   follow-up period. The decrease was dose-dependent. Bioinformatics analyses 
   identified 34 co-expressed targets for acupuncture, PD, and depression; and eight 
   hub genes (coding for interleukin 6 and 1B, tumor necrosis factor, albumin, 
   vascular endothelial growth factor A, C-reactive protein, 
   prostaglandin-endoperoxide synthase 2, and brain-derived neurotrophic factor) 
   potentially involved in the therapeutic effects of acupuncture. Several molecular 
   pathways were found to be involved, including cytokine-cytokine receptor 
   interaction, neuroactive ligand-receptor interaction, cyclic adenosine 
   3',5'-monophosphate signaling pathway, mitogen-activated protein kinase signaling 
   pathway, serotonergic synapse, and estrogen signaling pathway. LIMITATIONS: Bias 
   in the selection of participants could have been introduced as a consequence of 
   the retrospective nature of the study. Data were derived from a single national 
   database, and acupuncture treatment details were unavailable. CONCLUSION: 
   Acupuncture may protect against the development of depression in patients with 
   PD. This study provides insight into the potential molecular mechanisms 
   underlying the therapeutic effects of acupuncture in PD management and depression 
   prevention.
C1 Department of Post-Baccalaureate Veterinary Medicine, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan
   Chuyuan Chinese MedicineClinic, Taichung 40455, Taiwan.
   Management Office for Health Data, China Medical University Hospital, Taichung 40459, Taiwan.
   School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
   Department of Medical Research, China MedicalUniversity Hospital, Taichung 40402, Taiwan
   Division of Medical Genetics, ChinaMedical University Children's Hospital, Taichung 40447, Taiwan
   Department ofBiotechnology and Bioinformatics, Asia University, Taichung 41354, Taiwan.
   Department of Post-Baccalaureate Veterinary Medicine, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.
   School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
   Department of Chinese Medicine, China MedicalUniversity Hospital, Taichung 40447 , Taiwan. 
EM mli@mail.cmu.edu.tw
NR 0
TC 0
SN 1573-251
EI 
J9 J Affect Disord
PD OCT 11
PY 2023
VL 344
IS 
BP 48
EP 60
DI 10.1016/j.jad.2023.10.013 
PG 12
WC Female; Humans; Retrospective Studies; Vascular Endothelial Growth Factor A; Depression; Follow-Up Studies; Dysmenorrhea; therapy; Taiwan; Acupuncture Therapy
UT PubMed:37816484
PM 37816484
DA 2023-10-11
ER

PT J
AU Tseng, YL
   Hsu, CH
   Tseng, HC
AF Tseng, Yi-Ling
   Hsu, Chun-Hung
   Tseng, Hui-Chen
TI [Using Acupressure to Improve Abdominal Bloating in a Hemicolectomy Patient: A 
SO Hu li za zhi The journal of nursing
LA chi
DT Journal Article
DE Zusanli (ST-36); abdominal surgery; acupressure; bloating; nursing experience
AB This article describes a nursing experience applying the protocol of bilateral 
   Zusanli (ST-36) acupressure to reduce abdominal bloating in a colon cancer 
   patient who had undergone a right hemicolectomy. The period of care was between 
   November 13 and November 23, 2014. Data were collected through direct care, 
   interviews, observation, and physical assessment. The main health problems of the 
   patient included anxiety, surgical wound pain, and abdominal bloating. We 
   provided pre- and postoperative routine nursing care, wound pain management, and 
   the protocol of Zusanli (ST-36) acupressure for reducing abdominal bloating. 
   Results of care recorded the first passage of flatus and intestinal motility 
   during the second postoperative day, with no complaints of bloating from the 
   fourth postoperative day. The subject exhibited a relaxed mood and slept soundly 
   following each acupressure session. Furthermore, the subject reported 
   experiencing no abdominal bloating during the week following discharge, during 
   which he continued to follow the acupressure protocol. This article provides 
   support via an instance of nursing care for the effectiveness of the Zusanli 
   (ST-36) acupressure in improving abdominal bloating and thus reducing the 
   complications of hemicolectomy surgery.
C1 School of Nursing, Kaohsiung Medical University, Taiwan, ROC.
   Department of Traditional Chinese Medicine, Kaohsiung Medical University Hospital, Taiwan, ROC.
   School of Nursing, Kaohsiung Medical University, Taiwan, ROC. huchts@kmu.edu.tw.
NR 0
TC 0
SN 
EI 0047-262
J9 Hu Li Za Zhi
PD OCT 29
PY 2015
VL 62
IS 5
BP 96
EP 102
DI 10.6224/JN62.5.96 
PG 6
WC Acupressure; Colectomy; adverse effects; Gastrointestinal Motility; Humans; Male; Middle Aged; Postoperative Complications; prevention & control
UT PubMed:26507632
PM 26507632
DA 2015-10-29
ER

PT J
AU Ernst, E
   Lee, MS
AF Ernst, Edzard
   Lee, Myeong Soo
TI Acupuncture for palliative and supportive cancer care: a systematic review of 
SO Journal of pain and symptom management
LA English
DT Letter
NR 0
TC 0
SN 1873-651
EI 
J9 J Pain Symptom Manage
PD JUL 14
PY 2010
VL 40
IS 1
BP e3
EP 5
DI 10.1016/j.jpainsymman.2010.03.010 
PG 1
WC Acupuncture Therapy; Humans; Meta-Analysis as Topic; Neoplasms; complications; Pain; etiology; Pain Management; Palliative Care
UT PubMed:20619198
PM 20619198
DA 2010-07-14
ER

PT J
AU Sun, T
   Cui, CB
   Luo, JG
   Zhang, L
   Fu, ZJ
   Song, WG
AF Sun, Tao
   Cui, Cheng-bin
   Luo, Jian-gang
   Zhang, Li
   Fu, Zhi-jian
   Song, Wen-ge
TI [Effect of electroacupuncture on the expression of spinal glial fibrillary acidic 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
AB OBJECTIVE: To observe the effect of electroacupuncture (EA) on the expression of 
   spinal glial fibrillary acidic protein (GFAP), tumor necrosis factor-alpha 
   (TNF-alpha) and interleukin-1beta (IL-1beta) in chronic constriction injury (CCI) 
   rats. METHODS: Seventy-two SD rats were randomized into sham operation (sham), 
   CCI (model) and EA groups (n = 24/group). The mechanical and thermal pain 
   thresholds were measured by using Von Frey filaments and radiant-heat irridiation 
   separately. The immunoactivity of GFAP of spinal dorsal horn (L4-L5) was assessed 
   by immunohistochemistry, and the expression of spinal TNF-alpha mRNA and IL-1beta 
   mRNA was detected by real time-PCR. RESULTS: Compared with pre-CCI and sham 
   group, both mechanical and thermal pain thresholds decreased considerably in rats 
   with CCI (P < 0.05), and in comparison with model group, those of EA group 
   increased markedly (P < 0.05). Compared with sham group, GFAP immunoactivity 
   (mainly in the lamina I-II of the spinal dorsal horn), TNF-alpha mRNA and 
   IL-1beta mRNA expression in the ipsilateral spinal cord on the CCI side in model 
   group increased considerably (P < 0.05), while compared with model group, the 
   expression of GFAP, TNF-alpha mRNA and IL-1beta mRNA in EA group was 
   down-regulated remarkably (P < 0.05). CONCLUSION: EA can effectively suppress 
   CCI-induced up-regulation of expression of spinal GFAP, TNF-alpha mRNA and 
   IL-1beta mRNA, which may contribute to its effect in reducing mechanical 
   allodynia and thermal hyperalgesia in neuropathic pain rats.
C1 Department of Pain Management, the Affiliated Hospital of Shandong University, Jinan 250021, China. suntao@medmail.com.cn
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD MAY 13
PY 2010
VL 35
IS 1
BP 12
EP 6
DI 
PG -6
WC Animals; Chronic Disease; therapy; Electroacupuncture; Gene Expression; Glial Fibrillary Acidic Protein; genetics; Humans; Interleukin-1beta; genetics; Male; Neuralgia; genetics; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord; metabolism; Tumor Necrosis Factor-alpha; genetics; Up-Regulation
UT PubMed:20458900
PM 20458900
DA 2010-05-13
ER

PT J
AU Shi, C
   Liu, Y
   Zhang, W
   Lei, Y
   Lu, C
   Sun, R
   Sun, Y
   Jiang, M
   Gu, X
   Ma, Z
AF Shi, Changxi
   Liu, Yue
   Zhang, Wei
   Lei, Yishan
   Lu, Cui'e
   Sun, Rao
   Sun, Yu'e
   Jiang, Ming
   Gu, Xiaoping
   Ma, Zhengliang
TI Intraoperative electroacupuncture relieves remifentanil-induced postoperative 
SO Molecular pain
LA English
DT Journal Article
DE Electroacupuncture; glial cells; mitogen-activated protein kinases; postoperative hyperalgesia; proinflammatory cytokines; remifentanil-induced hyperalgesia
AB Background Accumulating studies have suggested that remifentanil, the widely-used 
   opioid analgesic in clinical anesthesia, can activate the pronociceptive systems 
   and enhance postoperative pain. Glial cells are thought to be implicated in 
   remifentanil-induced hyperalgesia. Electroacupuncture is a complementary therapy 
   to relieve various pain conditions with few side effects, and glial cells may be 
   involved in its antinociceptive effect. In this study, we investigated whether 
   intraoperative electroacupuncture could relieve remifentanil-induced 
   postoperative hyperalgesia by inhibiting the activation of spinal glial cells, 
   the production of spinal proinflammatory cytokines, and the activation of spinal 
   mitogen-activated protein kinases. Methods A rat model of remifentanil-induced 
   postoperative hyperalgesia was used in this study. Electroacupuncture during 
   surgery was conducted at bilateral Zusanli (ST36) acupoints. Behavior tests, 
   including mechanical allodynia and thermal hyperalgesia, were performed at 
   different time points. Astrocytic marker glial fibrillary acidic protein, 
   microglial marker Iba1, proinflammatory cytokines, and phosphorylated 
   mitogen-activated protein kinases in the spinal cord were detected by Western 
   blot and/or immunofluorescence. Results Mechanical allodynia and thermal 
   hyperalgesia were induced by both surgical incision and remifentanil infusion, 
   and remifentanil infusion significantly exaggerated and prolonged 
   incision-induced pronociceptive effects. Glial fibrillary acidic protein, Iba1, 
   proinflammatory cytokines (interleukin-1β and tumor necrosis factor-α), and 
   phosphorylated mitogen-activated protein kinases (p-p38, p-JNK, and p-ERK1/2) 
   were upregulated after surgical incision, remifentanil infusion, and especially 
   after their combination. Intraoperative electroacupuncture significantly 
   attenuated incision- and/or remifentanil-induced pronociceptive effects, spinal 
   glial activation, proinflammatory cytokine upregulation, and phosphorylated 
   mitogen-activated protein kinase upregulation. Conclusions Our study suggests 
   that remifentanil-induced postoperative hyperalgesia can be relieved by 
   intraoperative electroacupuncture via inhibiting the activation of spinal glial 
   cells, the upregulation of spinal proinflammatory cytokines, and the activation 
   of spinal mitogen-activated protein kinases.
C1 1 Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province, China.
   2 Department of Anesthesiology, Jiangsu Province Hospital on Integration of 
   3 Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Jiangsu Province, China.
   3 Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Jiangsu Province, China.
   3 Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Jiangsu Province, China.
   3 Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Jiangsu Province, China.
   3 Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Jiangsu Province, China.
   3 Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Jiangsu Province, China.
   3 Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Jiangsu Province, China.
   3 Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Jiangsu Province, China.
   3 Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Jiangsu Province, China.
NR 0
TC 0
SN 1744-806
EI 
J9 Mol Pain
PD AUG 22
PY 2017
VL 13
IS 
BP 1744806917725636
EP 1744806917725636
DI 10.1177/1744806917725636 
PG 1
WC Animals; Biomarkers; metabolism; Calcium-Binding Proteins; metabolism; Cytokines; metabolism; Electroacupuncture; Glial Fibrillary Acidic Protein; metabolism; Hyperalgesia; etiology; Inflammation Mediators; metabolism; Intraoperative Care; Male; Microfilament Proteins; metabolism; Mitogen-Activated Protein Kinases; metabolism; Neuroglia; metabolism; Pain, Postoperative; etiology; Phosphorylation; Piperidines; adverse effects; Rats, Sprague-Dawley; Remifentanil; Spinal Cord; pathology; Spinal Cord Dorsal Horn; metabolism; Up-Regulation
UT PubMed:28825338
PM 28825338
DA 2017-08-22
ER

PT J
AU Yue, P
   Gao, L
   Chen, M
   Guo, W
   Xin, SC
AF Yue, Ping
   Gao, Liang
   Chen, Mo
   Guo, Wen
   Xin, Sui-Cheng
TI [Effect of Warm-needle-moxibustion on Behavior Reactions and TNF-α and MMP-3 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
AB OBJECTIVE: To observe the effect of warm-needle-moxibustion on behavior changes 
   and the levels of tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-3 
   (MMP-3) in the knee cartilage tissue of rabbits with knee osteoarthritis (KOA) so 
   as to explore its mechanisms in relieving KOA. METHODS: Thirty male Japanese 
   white rabbits were randomly divided into normal, model and treatment groups (n=10 
   in each group). The KOA model was established by using immobilization me-thod. 
   The internal and external "Dubi" (ST 35), "Xuehai" (SP 10) and "Yanglingquan "(GB 
   34) were punctured with filiform needles first, followed by attaching an ignited 
   moxa column to the handle of each inserted needles. The treatment was conducted 
   for 20 min every time, once daily for 4 weeks. The behavioral scores were 
   assessed according to the pain severity, gait, joint motion range and articular 
   swelling severity in reference to the modified Lequesne's methods. The TNF-α and 
   MMP-3 contents in the knee joint cartilage tissue were assayed by 
   radioimmunoassay, and pathological changes of the articular cartilage tissue were 
   observed under microscope after sectioning and H.E. staining. RESULTS: The 
   Lequesne total score, and the cartilage TNF-α and MMP-3 contents were 
   significantly increased in the model group than in the normal group (P<0.05), and 
   obviously down-regulated after warm-needle-moxibustion intervention (P<0.05). 
   Under light microscope, the inflammatory infiltration of the articular cartilage 
   and the disordered arrangement of chondrocytes in KOA rabbits were improved in 
   the treatment group. CONCLUSIONS: Warm-needle-moxibustion intervention can 
   improve the motor function of rabbits with KOA, which may be related to its 
   effects in reducing the level of TNF-α and MMP-3 in articular cartilage tissue.
C1 School of Acu-moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
   China Rehabilitation Research Center, Beijing 100068.
   Beijing Massage Hospital, Beijing 100035.
   School of Acu-moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, Chin.
   School of Acu-moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, Chin. pro_xinsch@163.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUN 25
PY 2016
VL 41
IS 3
BP 235
EP 9
DI 
PG -226
WC Animals; Cartilage, Articular; chemistry; Knee Joint; Male; Matrix Metalloproteinase 3; analysis; Moxibustion; Osteoarthritis, Knee; therapy; Rabbits; Tumor Necrosis Factor-alpha; analysis
UT PubMed:29071912
PM 29071912
DA 2016-06-25
ER

PT J
AU Bao, T
   Goloubeva, O
   Pelser, C
   Porter, N
   Primrose, J
   Hester, L
   Sadowska, M
   Lapidus, R
   Medeiros, M
   Lao, L
   Dorsey, SG
   Badros, AZ
AF Bao, Ting
   Goloubeva, Olga
   Pelser, Colleen
   Porter, Neil
   Primrose, James
   Hester, Lisa
   Sadowska, Mariola
   Lapidus, Rena
   Medeiros, Michelle
   Lao, Lixing
   Dorsey, Susan G
   Badros, Ashraf Z
TI A pilot study of acupuncture in treating bortezomib-induced peripheral neuropathy 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; bortezomib; multiple myeloma; peripheral neuropathy
AB BACKGROUND: Peripheral neuropathy is the dose limiting toxicity of bortezomib in 
   patients with multiple myeloma (MM). OBJECTIVES: To examine the safety, 
   feasibility and efficacy of acupuncture in reducing bortezomib-induced peripheral 
   neuropathy (BIPN) symptoms. METHODS: Patients with MM experiencing persistent 
   BIPN ≥grade 2 despite adequate medical intervention and discontinuation of 
   bortezomib received 10 acupuncture treatments for 10 weeks (2×/week for 2 weeks, 
   1×/week for 4 weeks, and then biweekly for 4 weeks). Responses were assessed by 
   the Clinical Total Neuropathy Score (TNSc), Functional Assessment of Cancer 
   Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) questionnaire, 
   and the Neuropathy Pain Scale (NPS). Repeated-measures analysis of variance was 
   used to test for monotonic decline in scores on each of the measures. Serial 
   serum levels of proinflammatory and neurotrophic cytokines were obtained at 
   baseline and weeks 1, 2, 4, 8, and 14. RESULTS: Twenty-seven patients with MM 
   were enrolled in the trial. There were no adverse events associated with the 
   acupuncture treatments. TNSc data were deemed invalid and therefore were not 
   reported. At weeks 10 and 14, FACT/GOG-Ntx and NPS showed significant reduction 
   suggesting decreased pain, and improved function (P values were <.0001 for both 
   FACT/GOG-Ntx and NPS at weeks 10 and 14). However, nerve conduction studies did 
   not significantly change between baseline assessment and end of study. There was 
   no correlation in serum cytokines for responders versus none responders. 
   CONCLUSIONS: Acupuncture is safe, feasible and produces subjective improvements 
   in patients' symptoms. A follow-up randomized controlled trial is warranted.
C1 The University of Maryland School of Medicine, Baltimore, MD, USA baot@mskcc.org.
   The University of Maryland School of Medicine, Baltimore, MD, USA.
   The University of Maryland School of Medicine, Baltimore, MD, USA.
   The University of Maryland School of Medicine, Baltimore, MD, USA.
   The University of Maryland School of Medicine, Baltimore, MD, USA.
   The University of Maryland School of Medicine, Baltimore, MD, USA.
   The University of Maryland School of Medicine, Baltimore, MD, USA.
   The University of Maryland School of Medicine, Baltimore, MD, USA.
   The University of Maryland School of Medicine, Baltimore, MD, USA.
   The University of Maryland School of Medicine, Baltimore, MD, USA.
   The University of Maryland School of Medicine, Baltimore, MD, USA.
   The University of Maryland School of Medicine, Baltimore, MD, USA.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD MAY 29
PY 2014
VL 13
IS 5
BP 396
EP 404
DI 10.1177/1534735414534729 
PG 8
WC Acupuncture Therapy; adverse effects; Aged; Antineoplastic Agents; therapeutic use; Boronic Acids; adverse effects; Bortezomib; Cytokines; metabolism; Feasibility Studies; Humans; Middle Aged; Multiple Myeloma; drug therapy; Pain Measurement; Peripheral Nervous System Diseases; chemically induced; Pilot Projects; Pyrazines; adverse effects; Time Factors; Treatment Outcome
UT PubMed:24867959
PM 24867959
DA 2014-05-29
ER

PT J
AU Yu, R
   Guo, X
   Zhu, Y
   Chen, Y
   Zhang, C
   Chai, X
   Wang, Y
AF Yu, Ruifang
   Guo, Xinfeng
   Zhu, Yanjuan
   Chen, Yue
   Zhang, Canyang
   Chai, Xiaoshu
   Wang, Yingqi
TI Acupuncture reduced incidence of insomnia symptoms in patients with lung cancer: 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture; Insomnia symptoms; Lung cancer; Prevention
AB PURPOSE: About 30-50% of lung cancer patients suffer from insomnia with limited 
   prevention options. We conducted a retrospective cohort study to investigate 
   whether acupuncture for cancer-related symptoms such as pain could reduce the 
   incidence of insomnia symptoms. METHODS: We included newly diagnosed lung cancer 
   patients without prior insomnia symptoms from Guangdong Provincial Hospital of 
   Chinese Medicine (2012-2021) and followed up until January 31, 2022. Cases were 
   propensity score-matched by sex, age, ECOG PS score, pathological diagnosis, 
   therapy, and comorbidities. The main outcome was the incidence of insomnia 
   symptoms, identified by psychiatric diagnosis or insomnia symptoms in medical 
   records. RESULTS: Among 1295 lung cancer survivors, 918 patients were matched 
   (459 per group). Over an average follow-up of 218.6 days, insomnia symptoms were 
   observed in 20.9% of the acupuncture group and 42.2% of the non-acupuncture 
   group. Acupuncture was linked to a lower incidence of insomnia symptoms (adjusted 
   HR 0.31, 95% CI 0.23-0.39). Higher frequency and more numerous acupuncture 
   sessions further reduced the risk of insomnia symptoms (adjusted HR 0.15 for 
   frequency of 1 day/session, adjusted HR 0.15 for sessions > 16). The acupuncture 
   group had a significantly lower cumulative incidence of insomnia (log-rank test, 
   P < 0.01). CONCLUSION: Our results suggest that acupuncture may prevent the 
   incidence of insomnia symptoms in patients with lung cancer. Daily sessions and a 
   cumulative total of 16 or more treatments may enhance the benefit.
C1 Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
   Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital 
   Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
   Guangdong Provincial Key Laboratory of Clinical Research On Traditional Chinese 
   State Key Laboratory of Dampness, Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou,China.
   Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou, China.
   College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
   Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
   Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital 
   Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou, China. chaixiaoshu@126.com.
   First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China. wyq950101@126.com.
NR 0
TC 0
SN 1433-733
EI 0941-435
J9 Support Care Cancer
PD DEC 19
PY 2025
VL 34
IS 1
BP 45
EP 45
DI 10.1007/s00520-025-10256-8 
PG 0
WC Humans; Sleep Initiation and Maintenance ; Retrospective Studies; Male; Female; Acupuncture Therapy; methods; Lung Neoplasms; complications; Middle Aged; Incidence; Aged; Adult; Cohort Studies; China; epidemiology
UT PubMed:41417088
PM 41417088
DA 2025-12-19
ER

PT J
AU Li, ZH
   Zhao, XD
   Ming, SR
   Li, X
   Hu, JW
   Chen, YL
AF Li, Zhi-Hao
   Zhao, Xue-Dan
   Ming, Shu-Ren
   Li, Xu
   Hu, Jun-Wei
   Chen, Yue-Lai
TI [Effect of electroacupuncture on the morphology of prostate and degranulation of 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Chronic nonbacterial prostatitis; Collagen fiber; Electroacupuncture; Mast cell; Prostate
AB OBJECTIVE: To observe the effect of electroacupuncture (EA) on the morphology of 
   prostate and degranulation of mast cells in prostate of rats with chronic 
   nonbacterial prostatitis (CNP). METHODS: Male SD rats were randomly divided into 
   sham operation group, model group and EA group, with 8 rats in each group. CNP 
   model was established by surgical castration combined with 17-β estradiol 
   injection once daily for 30 days. EA was applied to "Zhongji" (CV3), "Guanyuan" 
   (CV4) and bilateral "Dahe" (KI12) for 20 min, once daily for 8 days. The 
   mechanical pain threshold of scrotum skin area was tested before modeling, after 
   modeling and after intervention. The pathological morphology of the prostate was 
   observed by HE staining. Collagenous fiber was observed by Masson staining. The 
   infiltration of mast cells was observed by toluidine blue staining. The contents 
   of interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) in prostate were 
   determined by ELISA. The protein expression levels of tryptase and transforming 
   growth factor β1 (TGF-β1) in prostate were detected by Western blot. RESULTS: A 
   normal appearance with little inflammatory cell infiltration was observed in the 
   prostate of the sham operation group. Gland atrophy, epithelial destruction, 
   hyperemia and edema, diffuse inflammatory cell infiltration and visible collagen 
   fiber deposition were observed in prostate of the model group. The degree of 
   infiltration of inflammatory cells and collagen fiber deposition were reduced in 
   the EA group. Compared with the sham operation group, mechanical pain threshold 
   was decreased (P<0.01), while the collagen volu-me fraction (CVF) of prostate, 
   the degranulated rate of mast cells, the protein expression levels of tryptase 
   and TGF-β1, and the contents of IL-6 and TNF-α were increased (P<0.01) in the 
   model group. Following EA intervention, compared with the model group, the 
   mechanical pain threshold was increased (P<0.01), CVF of the prostate, the 
   degranulated rate of mast cells, the protein expression levels of tryptase and 
   TGF-β1, and the contents of IL-6 and TNF-α were decreased (P<0.05, P<0.01) in the 
   EA group. CONCLUSION: EA can relieve pain and reduce inflammation and fibrosis of 
   prostate in CNP rats, which may be related to inhibiting the degranulation of 
   prostate mast cells and down-regulating the expression of inflammatory factors 
   and TGF-β1.
C1 Department of Acupuncture-Moxibustion, Tuina and Traumatology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200233, China.
   Department of Acupuncture and Moxibustion, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032.
   Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TraditionalChinese Medicine, Shanghai 200437.
   Department of Acupuncture and Moxibustion, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032.
   Department of Acupuncture and Moxibustion, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032.
   Department of Acupuncture and Moxibustion, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD FEB 4
PY 2023
VL 48
IS 1
BP 56
EP 62
DI 10.13702/j.1000-0607.20211148 
PG 6
WC Animals; Male; Rats; Electroacupuncture; Interleukin-6; genetics; Mast Cells; metabolism; Pain; Prostate; metabolism; Prostatitis; genetics; Rats, Sprague-Dawley; Transforming Growth Factor beta1; genetics; Tryptases; Tumor Necrosis Factor-alpha; genetics
UT PubMed:36734499
PM 36734499
DA 2023-02-04
ER

PT J
AU Gondim, DV
   Costa, JL
   Rocha, SS
   Brito, GA
   Ribeiro, Rde A
   Vale, ML
AF Gondim, Delane Viana
   Costa, Jéssyca Lima
   Rocha, Suellen Sousa
   Brito, Gerly Anne de Castro
   Ribeiro, Ronaldo de Albuquerque
   Vale, Mariana Lima
TI Antinociceptive and anti-inflammatory effects of electroacupuncture on 
SO Canadian journal of physiology and pharmacology
LA English
DT Journal Article
AB This study investigated the antinociceptive and anti-inflammatory effects of 
   electroacupuncture (EA) on zymosan-induced acute arthritis of the rat 
   temporomandibular joint (TMJ). Male Wistar rats were injected with saline or 
   zymosan (control group; 2 mg) into the left TMJ. Low frequency EA (10 Hz, 30 min) 
   was performed at acupoints (LI4, LI11, ST36, ST44) or sham points 2 h after or 
   1 h before zymosan administration. Mechanical hypernociception was accessed by 
   the electronic Von Frey method after zymosan administration. Rats were sacrificed 
   6 h after zymosan administration and the joint was removed for histopathological 
   analysis, myeloperoxidase activity assessment, vascular permeability 
   observations, and immunohistochemical verification of inflammatory mediators. The 
   results showed that EA inhibited zymosan-induced hypernociception, compared with 
   the control group and with the sham group (p < 0.05). The results showed that EA 
   inhibited inflammatory parameters such as neutrophil migration, vascular 
   permeability, and tumour necrosis factor α (TNF-α), cyclooxygenase-2 (COX-2), and 
   inducible nitric oxide synthase (iNOS) expression in the TMJ compared with the 
   sham group (p < 0.05). Histopathological analysis showed that EA significantly 
   inhibited edema and periarticular infiltration (p < 0.05) compared with the 
   control and sham groups. EA at acupoints produced antinociceptive and 
   anti-inflammatory effects on zymosan-induced arthritis in the rat TMJ.
C1 Medical Sciences Post-Graduation, Federal University of Ceará (UFC), Fortaleza, Ceará, Brazil. delanegondim@yahoo.com.br
NR 0
TC 0
SN 1205-754
EI 
J9 Can J Physiol Pharmacol
PD MAR 27
PY 2012
VL 90
IS 4
BP 395
EP 405
DI 10.1139/y2012-003 
PG 10
WC Acupuncture Points; Animals; Arthritis, Experimental; chemically induced; Capillary Permeability; drug effects; Edema; therapy; Electroacupuncture; methods; Inflammation; chemically induced; Inflammation Mediators; metabolism; Male; Nociceptive Pain; therapy; Peroxidase; metabolism; Rats; Temporomandibular Joint; metabolism; Zymosan
UT PubMed:22443108
PM 22443108
DA 2012-03-27
ER

PT J
AU Tang, H
   Fan, H
   Luo, F
   Huang, L
   Liao, S
   Yu, W
   Chen, Y
   Chen, J
   Qin, X
AF Tang, Hongzhi
   Fan, Huaying
   Luo, Fei
   Huang, Li
   Liao, Shichuan
   Yu, Wenjing
   Chen, Yunbei
   Chen, Jiao
   Qin, Xuefei
TI Acupuncture improves postoperative symptoms of pigmented villonodular synovitis: 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Pigmented villonodular synovitis (PVNS) is a benign proliferative 
   disease of synovial joint, synovial sac and tendon sheath. PVNS is usually 
   treated by surgery, but postoperative joint dysfunction and pain will be 
   accompanied, which seriously affects the quality of life. The purpose of this 
   review is to evaluate the effectiveness and safety of this intervention in 
   patients with pain and dysfunction caused by postoperative symptoms of PVNS. 
   METHODS: We will search the EMBASE, the Cochrane Library, Ovid MEDLINE, PubMed, 
   Web of Science, Chinese Biomedical Literature Database (CBM), Chinese National 
   Knowledge Infrastructure (CNKI), Wanfang Database, the Chongqing VIP (VIP), the 
   US National Institute of Health, the NIH clinical registry Clinical Trials, the 
   ICTRP, and the Australian New Zealand Clinical Trials Registry and the Chinese 
   clinical registry, from their inception to 1st July 2020. Randomized controlled 
   trials that include patients with postoperative symptoms of pigmented 
   villonodular synovitis receiving acupuncture therapy versus a control group will 
   be included. The selection of studies, data extraction and risk of bias 
   assessment will be conducted by 2 independent researchers. A third review author 
   resolved disagreements. The dichotomous data will be presented as risk ratios 
   with 95% confidence intervals (CIs) and the continuous data will be presented as 
   weighted mean differences or standardized mean differences with 95% CIs. Evidence 
   quality will be evaluated using the GRADE system. RESULTS: The results will be 
   disseminated through a peer-reviewed journal publication. CONCLUSIONS: This 
   systematic review will provide updated evidence of various types of acupuncture 
   specifically focuses on its effectiveness and safety for patients' pain and 
   dysfunction caused by post-operation of pigmented villonodular synovitis. ETHICS 
   AND DISSEMINATION: Ethical approval is not necessary as this review will not 
   require data from individual patients. The results of this will be published 
   through peer-reviewed journal articles or conference presentations. REGISTRATION: 
   Open Science Framework (OSF). 2020, July 7. 10.17605/OSF.IO/CZW9P.
C1 Outpatient Department of Sichuan Orthopedic Hospital.
   The Acupuncture and Tuina School, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu City, Sichuan Province, China.
   Outpatient Department of Sichuan Orthopedic Hospital.
   Outpatient Department of Sichuan Orthopedic Hospital.
   Outpatient Department of Sichuan Orthopedic Hospital.
   Outpatient Department of Sichuan Orthopedic Hospital.
   Outpatient Department of Sichuan Orthopedic Hospital.
   The Acupuncture and Tuina School, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu City, Sichuan Province, China.
   Outpatient Department of Sichuan Orthopedic Hospital.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD SEP 3
PY 2020
VL 99
IS 33
BP e21748
EP e21748
DI 10.1097/MD.0000000000021748 
PG 1
WC Acupuncture Therapy; Humans; Meta-Analysis as Topic; Pain, Postoperative; therapy; Synovitis, Pigmented Villonodular; rehabilitation; Systematic Reviews as Topic
UT PubMed:32872065
PM 32872065
DA 2020-09-03
ER

PT J
AU Chang, XS
   Zhu, YJ
   Peng, JJ
   Wu, XY
   Wang, W
   Liu, YH
   Zhan, DD
   Chen, YD
   Zhang, HB
AF Chang, Xue-Song
   Zhu, Yan-Juan
   Peng, Jian-Jun
   Wu, Xiao-Yu
   Wang, Wei
   Liu, Yi-Hong
   Zhan, Dan-Dan
   Chen, Ya-Dong
   Zhang, Hai-Bo
TI [Clinical observation on acupuncture for symptom burden in gastric cancer 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture; adjuvant chemotherapy; frequency of treatment; gastric cancer; randomized controlled trial (RCT); symptom burden
AB OBJECTIVE: To observe the efficacy of acupuncture on symptom burden in patients 
   with gastric cancer during adjuvant chemotherapy after gastrectomy. METHODS: A 
   total of 58 patients were randomized into a high-dose acupuncture group (19 
   cases, 5 cases dropped off), a low-dose acupuncture group (20 cases, 6 cases 
   dropped off) and a control group (19 cases, 2 cases dropped off). Conventional 
   chemotherapy and antiemetic treatment were adopted in the control group. On the 
   basis of the treatment in the control group, acupuncture was applied 7 times each 
   chemotherapy cycle for totally 21 times in the high-dose acupuncture group, and 3 
   times each chemotherapy cycle for totally 9 times in the low-dose acupuncture 
   group. Baihui (GV 20), Zusanli (ST 36), Neiguan (PC 6), etc. were selected in the 
   two acupuncture groups, as well as back-shu points selected by the meridian heat 
   sensing technique. Electroacupuncture was connected to ipsilateral Zusanli (ST 
   36) and Neiguan (PC 6), with continuous wave, 2 Hz in frequency for 20 min. The 
   Edmonton symptom assessment system (ESAS) score was observed on day 1-7, 14, and 
   21 of each cycle of chemotherapy respectively in the 3 groups. RESULTS: The 
   symptom burden was worst within 7 days of each cycle of chemotherapy in the 3 
   groups. After the 3rd chemotherapy cycle, the total score of ESAS in the low-dose 
   acupuncture group was lower than the control group (P<0.05), the total score and 
   the scores of feeling of non-well being, pain and shortness of breath of ESAS in 
   the acupuncture group (the high-dose acupuncture group combined with the low-dose 
   acupuncture group) were lower than the control group (P<0.05). CONCLUSION: 
   Acupuncture shows promising effect in controlling symptom burden during adjuvant 
   chemotherapy in gastric cancer patients after gastrectomy.
C1 Guangdong Provincial Hospital of TCM, Second Affiliated Hospital of Guangzhou University of CM, Guangzhou 510120, China.
   Guangdong Provincial Hospital of TCM, Second Affiliated Hospital of Guangzhou University of CM, Guangzhou 510120, China
   Guangdong Provincial Key Laboratory ofClinical Research on TCM Syndrome
   Guangdong-Hong Kong-Macau Joint Lab on ChineseMedicine and Immune Disease Research.
   First Affiliated Hospital, Sun Yat-sen University.
   Jiangsu Province Hospital of CM/Affiliated Hospital of Nanjing University of Chinese Medicine.
   Guangdong Provincial Hospital of TCM, Second Affiliated Hospital of Guangzhou University of CM, Guangzhou 510120, China.
   Guangdong Provincial Hospital of TCM, Second Affiliated Hospital of Guangzhou University of CM, Guangzhou 510120, China.
   Second Clinical Medical College of Guangzhou University of CM.
   Guangdong Provincial Hospital of TCM, Second Affiliated Hospital of Guangzhou University of CM, Guangzhou 510120, China.
   Guangdong Provincial Hospital of TCM, Second Affiliated Hospital of Guangzhou University of CM, Guangzhou 510120, China
   Guangdong Provincial Key Laboratory ofClinical Research on TCM Syndrome
   Guangdong-Hong Kong-Macau Joint Lab on ChineseMedicine and Immune Disease Research
   State Key Laboratory of Dampness Syndromeof Chinese Medicine.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD NOV 19
PY 2022
VL 42
IS 11
BP 1226
EP 32
DI 10.13703/j.0255-2930.20211106-k0004 
PG -1194
WC Humans; Acupuncture Points; Stomach Neoplasms; drug therapy; Acupuncture Therapy; Gastrectomy; adverse effects; Chemotherapy, Adjuvant
UT PubMed:36397219
PM 36397219
DA 2022-11-19
ER

PT J
AU Gim, GT
   Lee, JH
   Park, E
   Sung, YH
   Kim, CJ
   Hwang, WW
   Chu, JP
   Min, BI
AF Gim, Gyeong-Taek
   Lee, Ji-Hye
   Park, Eunkuk
   Sung, Yun-Hee
   Kim, Chang-Ju
   Hwang, Wei-Wan
   Chu, Jong-Phil
   Min, Byung-Il
TI Electroacupuncture attenuates mechanical and warm allodynia through suppression 
SO Brain research bulletin
LA English
DT Journal Article
AB Neuropathic pain remains one of the most difficult clinical pain syndromes to 
   treat. It is traditionally viewed as being mediated solely by neurons; however, 
   glial cells have recently been implicated as powerful modulators of pain. It is 
   known that the analgesic effects of electroacupuncture (EA) are mediated by 
   descending pain inhibitory systems, which mainly involve spinal opioid, 
   adrenergic, dopaminergic, serotonergic, and cholinergic receptors. However, 
   studies investigating the suppressive effects of EA on spinal glial activation 
   are rare. In the present study, we assessed the cumulative analgesic effects of 
   EA on mechanical and warm allodynia in a rat model of neuropathic pain. We 
   investigated the clinical efficacy of EA as long-term therapy and examined its 
   effects on spinal glia, matrix metalloproteinase (MMP)-9/MMP-2, proinflammatory 
   cytokines and serum immunoglobulin G (IgG) concentration. Rats were randomly 
   divided into four groups as follows: the operation group (OP), operation with 
   EA-non acupoint (EA-NA), operation with EA-ST36 acupoint (EA-ST36), and sham 
   operation (shamOP). Following neuropathic or sham surgery, repeated EA was 
   performed every other day after the behavioral test. On day 53 after the 
   behavioral test, rats were perfused for immunohistochemistry and Western blot 
   analysis to observe quantitative changes in spinal glial markers such as OX-42, 
   astrocytic glial fibrillary acidic protein (GFAP), MMP-9/MMP-2, and 
   proinflammatory cytokines. Allodynia and OX-42/GFAP/MMP-9/MMP-2/tumor necrosis 
   factor (TNF)-α/interleukin (IL)-1β activity in the EA-ST36 group was 
   significantly reduced, compared to the OP and EA-NA groups, and IgG in EA-ST36 
   rats significantly increased. Our results suggest that the analgesic effect of EA 
   may be partly mediated via inhibition of inflammation and glial activation and 
   repeated EA stimulation may be useful for treating chronic pain clinically.
C1 Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul, South Korea.
NR 0
TC 0
SN 1873-274
EI 
J9 Brain Res Bull
PD OCT 1
PY 2011
VL 86
IS 5-6
BP 403
EP 11
DI 10.1016/j.brainresbull.2011.09.010 
PG -392
WC Animals; Disease Models, Animal; Electroacupuncture; methods; Humans; Hyperalgesia; therapy; Immunoglobulin G; blood; Interleukin-1beta; metabolism; Interleukin-6; metabolism; Male; Matrix Metalloproteinase 2; metabolism; Matrix Metalloproteinase 9; metabolism; Neuralgia; physiopathology; Neuroglia; metabolism; Pain Measurement; Physical Stimulation; methods; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord; cytology; Temperature; Tumor Necrosis Factor-alpha; metabolism
UT PubMed:21958939
PM 21958939
DA 2011-10-01
ER

PT J
AU Bao, T
   Baser, R
   Chen, C
   Weitzman, M
   Zhang, YL
   Seluzicki, C
   Li, QS
   Piulson, L
   Zhi, WI
AF Bao, Ting
   Baser, Raymond
   Chen, Connie
   Weitzman, Matthew
   Zhang, Yi Lily
   Seluzicki, Christina
   Li, Qing Susan
   Piulson, Lauren
   Zhi, W Iris
TI Health-Related Quality of Life in Cancer Survivors with Chemotherapy-Induced 
SO The oncologist
LA English
DT Journal Article
DE Acupuncture; Anxiety; Cancer; Insomnia; Neuropathy; Quality of life
AB BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, 
   debilitating adverse effect of neurotoxic chemotherapy that significantly worsens 
   the quality of life of cancer survivors. MATERIALS AND METHODS: Survivors of 
   solid tumors with persistent moderate-to-severe CIPN defined as numbness, 
   tingling, or pain rated ≥4 on an 11-point numeric rating scale (NRS) were 
   randomized in a 1:1:1 ratio to 8 weeks of real acupuncture (RA) versus sham 
   acupuncture (SA) versus usual care (UC). We previously reported the primary 
   endpoint (NRS); here we report the following health-related quality of life 
   endpoints: Functional Assessment of Cancer Therapy/Gynecologic Oncology 
   Group-Neurotoxicity (FACT/GOG-Ntx), Hospital Anxiety and Depression Scale (HADS), 
   Insomnia Severity Index (ISI), and Brief Fatigue Inventory (BFI). For each 
   endpoint, the mean changes from baseline and 95% confidence intervals were 
   estimated within each arm and compared between arms using linear mixed models. 
   RESULTS: We enrolled 75 survivors of solid tumors with moderate-to-severe CIPN 
   into the study. Compared with baseline, at week 8, FACT/GOG-Ntx, HADS anxiety, 
   and ISI scores significantly improved in RA and SA, but not in UC. Compared with 
   UC, at week 8, FACT/GOG-Ntx scores significantly increased in RA and SA arms 
   indicating improved CIPN-related symptoms and quality of life (p = .001 and 
   p = .01). There was no statistically significant difference between RA and SA. 
   There was no difference in HADS depression or BFI among RA, SA, and UC at weeks 8 
   and 12. CONCLUSION: Acupuncture may improve CIPN-related symptoms and quality of 
   life in cancer survivors with persistent CIPN. Further large sample size studies 
   are needed to delineate placebo effects. IMPLICATIONS FOR PRACTICE: The authors 
   conducted a randomized sham acupuncture- and usual care-controlled clinical trial 
   to evaluate the impact of acupuncture on health-related quality of life outcomes 
   in patients with solid tumors with chemotherapy-induced peripheral neuropathy 
   (CIPN). Statistically significant improvements in quality of life, anxiety, 
   insomnia, and fatigue were achieved with 8 weeks of real acupuncture when 
   compared with baseline, without statistically significant differences between 
   real and sham acupuncture. These findings suggest that acupuncture may be 
   effective for improving CIPN-related symptoms and quality of life and reducing 
   anxiety and insomnia in cancer survivors with persistent CIPN, with further study 
   needed to delineate placebo effects.
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Epidemiology and Biostatics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Medicine, New York University Winthrop Hospital, Mineola, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Commack, New York, USA.
NR 0
TC 0
SN 1549-490
EI 1083-715
J9 Oncologist
PD AUG 15
PY 2021
VL 26
IS 11
BP e2070
EP e2078
DI 10.1002/onco.13933 
PG 1
WC Acupuncture Therapy; Antineoplastic Agents; adverse effects; Cancer Survivors; Female; Humans; Neoplasms; drug therapy; Peripheral Nervous System Diseases; chemically induced; Quality of Life
UT PubMed:34390283
PM 34390283
DA 2021-08-15
ER

PT J
AU Liu, YH
   Ye, Y
   Zheng, JB
   Wang, XQ
   Zhang, Y
   Lin, HS
AF Liu, Yi-Hua
   Ye, Yang
   Zheng, Jia-Bin
   Wang, Xue-Qian
   Zhang, Ying
   Lin, Hong-Sheng
TI Acupuncture for enhancing early recovery of bowel function in cancer: Protocol 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Cancer patients undergoing surgical procedure often suffer from bowel 
   dysfunction and postoperative ileus (POI). Cancer management for early recovery 
   of bowel function is still a challenging topic. Acupuncture has been commonly 
   used in a variety of gastrointestinal diseases. The aim of this study is to 
   evaluate the effects of acupuncture therapy to reduce the duration of POI and 
   enhance bowel function in cancer patients. METHODS: We will systematically screen 
   all randomized controlled trials (RCTs) published through electronically and hand 
   searching. The following search engines including Medline, EMBASE, Cochrane 
   CENTRAL, the Cumulative Index to Nursing and Allied Health Literature, Allied and 
   Complementary Medicine Database, the Chinese Biomedical Literature Database, the 
   China National Knowledge Infrastructure, VIP Information, Wanfang Data, one 
   Japanese database (Japan Science and Technology Information Aggregator, 
   Electronic) and 2 Korean Medical Databases (Korean Studies Information, and Data 
   Base Periodical Information Academic) will be retrieved. Supplementary sources 
   will be searched including gray literature, conference proceedings, and potential 
   identified publications. Two reviewers will independently conduct the trial 
   inclusion, data extraction and assess the quality of studies. The time to first 
   passing flatus and time to first bowel motion will be assessed as the primary 
   outcomes. Adverse effects, time to first bowel sound, visual analog scale (VAS) 
   pain score, hospital stay, and postoperative analgesic requirement will be 
   measured as secondary outcomes. Methodological quality will be evaluated 
   according to the Cochrane risk of bias. Details of interventions will be assessed 
   by the Standards for Reporting Interventions in Controlled Trials of Acupuncture 
   (STRICTA) checklist. All analyses will be applied by RevMan (version 5.3) and 
   StataSE (version 12). ETHICS AND DISSEMINATION: This systematic review will 
   provide up-to-date information on acupuncture therapy for early recovery of bowel 
   function in cancer patients. This review does not require ethical approval and 
   will be reported in a peer-reviewed journal and presented at a relevant 
   conference. TRIAL REGISTRATION NUMBER: PROSPERO CRD42016049633.
C1 Graduate School of Beijing University of Chinese Medicine Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD APR 27
PY 2017
VL 96
IS 17
BP e6644
EP e6644
DI 10.1097/MD.0000000000006644 
PG 1
WC Acupuncture Therapy; Humans; Ileus; etiology; Neoplasms; complications; Postoperative Complications; therapy; Randomized Controlled Trials as Topic; Research Design; Systematic Reviews as Topic
UT PubMed:28445263
PM 28445263
DA 2017-04-27
ER

PT J
AU Fu, T
   Wang, L
   Du, J
   Chen, F
   Fang, J
   Liang, Y
   Fang, J
AF Fu, Taofang
   Wang, Lingling
   Du, Junying
   Chen, Feng
   Fang, Junfan
   Liang, Yi
   Fang, Jianqiao
TI [Effects of electroacupuncture on expression of μ-opioid receptor in nucleus 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE bone cancer pain; electroacupuncture (EA); morphine tolerance; μ-opioid receptor
AB OBJECTIVE: To observe the effects of electroacupuncture (EA) on pain behavior in 
   rats with bone cancer pain and morphine tolerance, and to explore partial action 
   mechanism. METHODS: Forty-two SD healthy female rats were randomly divided into a 
   sham operation group (7 rats), a bone cancer pain group (8 rats), a morphine 
   tolerance group (9 rats), an EA group (9 rats) and a sham EA group (9 rats). The 
   rats in the sham operation group were treated with injection of phosphate buffer 
   saline at medullary cavity of left-side tibia, and the rats in the remaining 
   groups were injected with MRMT-1 breast cancer cells. After operation, no 
   treatment was given to rats in the sham operation group and bone cancer pain 
   group. 11 days after operation, rats in the morphine tole-rance group, EA group 
   and sham EA group were treated with intraperitoneal injection of morphine 
   hydrochloride, once every 12 hours, for 11 days to establish the model of bone 
   cancer pain and morphine tolerance. One day after the establishment of this bone 
   cancer pain model, the rats in the morphine tolerance group were injected with 
   morphine, once every 12 hours (9:00 a.m. and 9:00 p.m.) for 7 days; the rats in 
   the EA group and sham EA group were injected with morphine at 9:00 a.m., and 
   treated with EA (2 Hz/100 Hz) and sham EA (only injected into the subcutaneous 
   tissue) at bilateral "Zusanli" (ST 36) and "Kunlun" (BL 60), 30 min per 
   treatment, once a day for 7 days. One day before cancer cell injection, 6 days, 8 
   days, 10 days after operation, after 30 min on 1 days, 5 days, 9 days, 11 days of 
   morphine injection, and after 30 min on 1 days, 3 days, 5 days, 7 days of EA 
   treatment, the paw withdrawal threshold (PWT) was measured in each group. On 11 
   day of morphine injection, HE staining was applied to observe the morphology and 
   structure change of tibia in the sham operation group, bone cancer pain group and 
   morphine tolerance group, random 2 rats in each group. On 7 days of EA treatment, 
   fluorescent immunohistochemical method was applied to observe the expression of 
   μ-opioid receptor positive cells in nucleus ceruleus in each group, random 4 rats 
   in each one. RESULTS: After 10 days of the cancer cells injection, the PWT of 28 
   rats of bone cancer pain model (8 rats in the bone cancer pain group, 8 rats in 
   the morphine tolerance group, 6 rats in the EA group and 6 rats in the sham EA 
   group) was significantly lower than that of 7 rats in the sham operation group 
   (P<0.01). After one day of morphine injection, the PWT of the morphine tolerance 
   group, EA group and sham EA group was higher than that of the bone cancer pain 
   group (all P<0.01); on 11 d of morphine injection, the PWT of the morphine 
   tolerance group, EA group and sham EA group was not significantly different from 
   that of the bone cancer pain group (all P>0.05). On 11 d of morphine injection, 
   the tumor induced by cancer cells was observed in upper 1/3 tibia in the bone 
   cancer pain group and morphine tolerance group, and the marrow cavity was filled 
   with MRMT-1 cancer cells; no abnormal change was observed in the sham operation 
   group. On 1 d, 3 d, 5 d and 7 d of EA treatment, the PWT of the cancer pain 
   group, morphine tolerance group and sham EA group was lower than that of the EA 
   group (all P<0.01). On 7 d of EA treatment, the positive expression of MOR in 
   nucleus ceruleus in the cancer pain group, morphine tolerance group, EA group and 
   sham EA group was lower than that in the sham operation group (P<0.01, P<0.05), 
   and that in the cancer pain group, morphine tolerance group and sham EA group was 
   lower than that in the EA group (all P<0.01). CONCLUSIONS: EA can improve 
   mechanical pain threshold in rats with bone cancer pain-morphine tolerance, and 
   improve the abnormal pain, which is likely to be involved with improvement of the 
   MOR positive cells expression in nucleus ceruleus by EA.
C1 Laboratory of Acupuncture and Neurobiology, the Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Laboratory of Acupuncture and Neurobiology, the Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Laboratory of Acupuncture and Neurobiology, the Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Department of Acupuncture and Moxibustion, the First Affiliated Hospital of Jiaxing University.
   Laboratory of Acupuncture and Neurobiology, the Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Laboratory of Acupuncture and Neurobiology, the Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
   Laboratory of Acupuncture and Neurobiology, the Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD DEC 13
PY 2017
VL 37
IS 5
BP 513
EP 520
DI 10.13703/j.0255-2930.2017.05.017 
PG 7
WC Analgesics, Opioid; therapeutic use; Animals; Cancer Pain; metabolism; Electroacupuncture; Female; Locus Coeruleus; metabolism; Morphine; therapeutic use; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; metabolism
UT PubMed:29231613
PM 29231613
DA 2017-12-13
ER

PT J
AU Zhang, M
   Zhao, N
   Yang, G
   Zhang, HH
   Li, JL
AF Zhang, Meng
   Zhao, Nan
   Yang, Ge
   Zhang, Huan-Huan
   Li, Jian-Li
TI [Effects of transcutaneous electrical acupoint stimulation at Neiguan (PC6) and 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Autonomic nervous system; Elderly; Frailty; Heart rate variability; Transcutaneous electrical acupoint stimulation
AB OBJECTIVES: To explore the effects of transcutaneous electrical acupoint 
   stimulation (TEAS) at the bilateral acupoints Neiguan (PC6) and Jianshi (PC5) on 
   heart rate variability (HRV) and inflammatory factors in frail elderly patients 
   undergoing laparoscopic colorectal cancer surgery under general anesthesia. 
   METHODS: A total of 78 frail elderly patients undergoing elective laparoscopic 
   colorectal cancer surgery were randomized into the TEAS group (39 patients, with 
   2 patients dropping out) and the control group (39 patients, with 1 patient 
   dropping out). In the TEAS group, TEAS was applied to the bilateral PC6 and PC5 
   from 30 min before anesthesia induction until the end of the surgery. The control 
   group was connected to an electronic acupuncture instrument at the same acupoints 
   but did not receive electrical stimulation. A short-term Holter electrocardiogram 
   was used to collect HRV parameters in the frequency domain, including 
   low-frequency power (LF), high-frequency power (HF), and the LF/HF ratio. Serum 
   concentrations of C-reactive protein (CRP) and interleukin-6 (IL-6) were measured 
   using ELISA. The Quality of Recovery-15 (Qor-15) score was recorded, along with 
   adverse reactions such as postoperative nausea and vomiting (PONV), palpitations, 
   chest tightness, and chest pain. RESULTS: Compared with 1 d before surgery, LF 
   and HF were significantly decreased (P<0.05), and the LF/HF ratio significantly 
   increased (P<0.05) at 1, 2, and 3 d after surgery in the control group. In the 
   TEAS group, both LF and the LF/HF ratio were significantly decreased (P<0.05) at 
   1, 2, and 3 d after surgery. Compared with the control group, LF and HF levels 
   were significantly increased (P<0.05), and the LF/HF ratio was significantly 
   decreased (P<0.05) in the TEAS group at 1, 2, and 3 d after surgery. Both groups 
   exhibited increased levels of CRP and IL-6 at 1, 3, and 5 d after surgery 
   compared to 1 d before surgery (P<0.05), with the TEAS group showing lower CRP 
   and IL-6 levels than the control group (P<0.05). Compared to baseline before 
   surgery, the Qor-15 scores of both groups were decreased at 1, 2, and 3 d after 
   surgery (P<0.05), with the TEAS group showing significantly higher Qor-15 scores 
   than those in the control group (P<0.05). The incidence of PONV, palpitations, 
   chest tightness, and chest pain in the TEAS group was lower than that in the 
   control group (P<0.05). CONCLUSIONS: TEAS at the PC6 and PC5 can regulate 
   autonomic nervous function, reduce the early postoperative sympathetic nerve 
   excitation, maintain parasympathetic nerve tension, reduce inflammatory 
   responses, improve the quality of postoperative recovery, and decrease the 
   incidence of postoperative adverse reactions in frail elderly patients after 
   laparoscopic colorectal cancer surgery.
C1 Department of Anesthesia, Hebei General Hospital, Shijiazhuang 050051, China.
   Department of Anesthesia, The Third Hospital of Hebei Medical University, Shijiazhuang 050051.
   Department of Anesthesia, Hebei General Hospital, Shijiazhuang 050051, China.
   Department of Anesthesia, Hebei General Hospital, Shijiazhuang 050051, China.
   Department of Anesthesia, Hebei General Hospital, Shijiazhuang 050051, China. hblijianli@163.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUL 22
PY 2025
VL 50
IS 7
BP 815
EP 821
DI 10.13702/j.1000-0607.20241107 
PG 6
WC Humans; Acupuncture Points; Female; Male; Aged; Interleukin-6; blood; Transcutaneous Electric Nerve Stimulation; C-Reactive Protein; metabolism; Aged, 80 and over; Frail Elderly; Autonomic Nervous System; physiopathology; Heart Rate; Colorectal Neoplasms; surgery
UT PubMed:40691032
PM 40691032
DA 2025-07-22
ER

PT J
AU Mao, JJ
   Leed, R
   Bowman, MA
   Desai, K
   Bramble, M
   Armstrong, K
   Barg, F
AF Mao, Jun J
   Leed, Rana
   Bowman, Marjorie A
   Desai, Krupali
   Bramble, Manuel
   Armstrong, Katrina
   Barg, Frances
TI Acupuncture for hot flashes: decision making by breast cancer survivors.
SO Journal of the American Board of Family Medicine : JABFM
LA English
DT Journal Article
AB PURPOSE: Hot flashes (HFs) are a particularly common and distressing symptom 
   among breast cancer survivors (BCSs). Given its low rate of side effects, 
   acupuncture shows promise as a therapeutic approach for HFs, but little is known 
   about BCS's decision making about the use of acupuncture. This study seeks to 
   identify attitudes and beliefs about using acupuncture for HFs by BCSs. METHODS: 
   Using the Theory of Planned Behavior (TPB) as a conceptual framework, we 
   conducted semistructured interviews among women with stage I-III breast cancer 
   who had finished primary treatment and were currently experiencing HFs. 
   Interviews were taped, transcribed, and coded. We used a modified grounded theory 
   approach to analyze the data. RESULTS: Twenty-five BCSs (13 whites/12 African 
   American) participated in the study. Respondents stated that their intended use 
   of acupuncture for HFs would be dependent on (1) expected therapeutic effects 
   (eg, pain relief, energy); (2) practical concerns (eg, fear of needles, 
   practitioner experience, time commitment); and (3) source of decision 
   support/validation (eg, family members, physicians, self). Although constructs in 
   the TPB accounted for many decision factors, respondents identified 2 major 
   themes outside of the TPB: (1) viewing acupuncture as a natural alternative to 
   medications, and (2) assessing the degree of HFs as bothersome enough in the 
   context of other medical comorbidities to trigger the need for therapy. 
   CONCLUSION: BCSs expressed varied expected therapeutic benefits, practical 
   concerns, and decision support, emphasizing the "natural appeal" and symptom 
   appraisal as key determinants when using acupuncture for HFs. Incorporating these 
   factors in counseling BCSs may promote patient-centered communication, leading to 
   improved hot flash management and quality of life.
C1 Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. maoj@uphs.upenn.edu
NR 0
TC 0
SN 1558-711
EI 1557-262
J9 J Am Board Fam Med
PD MAY 10
PY 2012
VL 25
IS 3
BP 323
EP 32
DI 10.3122/jabfm.2012.03.110165 
PG -291
WC Acupuncture Therapy; methods; Adult; Aged; Breast Neoplasms; complications; Decision Making; Decision Support Techniques; Female; Health Knowledge, Attitudes, Practice; Hot Flashes; etiology; Humans; Interview, Psychological; Middle Aged; Survivors; Time Factors; Women's Health
UT PubMed:22570396
PM 22570396
DA 2012-05-10
ER

PT J
AU Zhao, Q
   Zhang, J
   Shi, W
   Qian, X
   An, J
AF Zhao, Qiannan
   Zhang, Jianfeng
   Shi, Wanrui
   Qian, Xiaoyan
   An, Jianxiong
TI Different mechanisms of electroacupuncture and pregabalin in neuropathic 
SO Neurological research
LA English
DT Journal Article
DE Neuropathic pain; electroacupuncture; morphology; pregabalin; structural changes
AB OBJECTIVES: Brachial plexus neuralgia (BPN) can result from injury, trauma, or 
   cancer, and it significantly impacts the patient's quality of life. This study 
   investigated electroacupuncture (EA) vs. pregabalin on the structural changes in 
   the peripheral nervous system (PNS) and central nervous system (CNS) in rats with 
   BPN. METHODS: Male Sprague-Dawley rats were randomized to the sham-operated 
   (Con), BPN (using cobra venom), BPN+EA (EA), and BPN+pregabalin (PGB) groups 
   (n = 8/group). EA or pregabalin was given from postoperative day (POD)14 to 
   POD35. Structural alterations were determined by transmission electron microscopy 
   in the primary sensory cortex, forelimb region (S1FL), anterior cingulate cortex 
   (ACC), hippocampus, thalamus, cervical, thoracic, and lumbar spinal cords on 
   POD40, and in the bilateral brachial plexus and dorsal root ganglions (DRG) at 
   the cervical, thoracic and lumbar levels. RESULTS: Compared with the CON group, 
   BPN rats exhibited significant changes in mechanical withdrawal threshold (MWT) 
   (p < 0.05). The MWT showed a significant increase compared with the BNP group 
   after EA or pregabalin (p < 0.05), but the long-term analgesic effects of EA 
   appeared superior to pregabalin (p < 0.05). Furthermore, EA alleviated myelin 
   sheath damage at the spinal cord levels. Damage, including demyelination, was 
   limited to the ipsilateral DRG at the corresponding segment and bilateral CNS. 
   CONCLUSION: Neuropathic pain-induced damage is limited to the ipsilateral DRG at 
   corresponding segment and bilateral CNS pain centers. EA and pregabalin each 
   partially attenuate neuropathic pain and alleviate neuronal damage in BPN, but EA 
   has a longer-term analgesic effect.
C1 Department of Anesthesiology, Pain and Sleep Medicine, Chinese Academy of Sciences, Aviation General Hospital of China Medical University and BeijingInstitute of Translational Medicine, Beijing, China.
   Department of Anesthesiology, Peking University People's Hospital, Beijing, China.
   Department of Ultrasound, Peking University Third Hospital, Beijing, China.
   Department of Anesthesiology, Pain and Sleep Medicine, Chinese Academy of Sciences, Aviation General Hospital of China Medical University and BeijingInstitute of Translational Medicine, Beijing, China.
   Department of Anesthesiology, Pain and Sleep Medicine, Chinese Academy of Sciences, Aviation General Hospital of China Medical University and BeijingInstitute of Translational Medicine, Beijing, China.
   School of Anesthesiology, Department of Pain Medicine, Affiliated Hospital of 
NR 0
TC 0
SN 1743-132
EI 
J9 Neurol Res
PD JUN 11
PY 2025
VL 47
IS 12
BP 1139
EP 1152
DI 10.1080/01616412.2025.2515195 
PG 13
WC Animals; Pregabalin; therapeutic use; Electroacupuncture; methods; Rats, Sprague-Dawley; Male; Disease Models, Animal; Neuralgia; therapy; Analgesics; therapeutic use; Rats; Brachial Plexus Neuropathies; therapy; Brachial Plexus; pathology; Ganglia, Spinal; ultrastructure; Spinal Cord; ultrastructure; Pain Threshold; drug effects; Microscopy, Electron, Transmission
UT PubMed:40494390
PM 40494390
DA 2025-06-11
ER

PT J
AU He, Y
   Lu, LY
   Chen, MJ
   Wen, Q
   Li, N
AF He, Ying
   Lu, Ling-Yun
   Chen, Ming-Jin
   Wen, Qian
   Li, Ning
TI [Postoperative ileus after laparotomy for gastrointestinal cancer treated with 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE electroacupuncture; gastrointestinal cancer; gastrointestinal function; postoperative ileus; randomized controlled trial (RCT)
AB OBJECTIVE: To observe the effect of electroacupuncture (EA) on postoperative 
   ileus after laparotomy for gastrointestinal cancer. METHODS: A total of 90 
   patients with postoperative ileus after laparotomy for gastrointestinal cancer 
   were randomized into an EA group and a conventional treatment group, 45 cases in 
   each one. In the conventional treatment group, the postoperative fast track 
   surgical regimen was accepted. In the EA group, on the base of the treatment as 
   the conventional treatment group, acupuncture was applied to Zusanli (ST 36), 
   Shangjuxu (ST 37), Yinlingquan (SP 9) and Taichong (LR 3) and electric 
   stimulation was attached on Zusanli (ST 36) and Yinlingquan (SP 9), with 
   continuous wave, 2 Hz in frequency and 3-5 mA in intensity. Acupuncture was 
   provided once daily till the onset of postoperative exhaust and defecation. The 
   first postoperative exhaust time, the first postoperative defecation time, the 
   postoperative hospital stay and the wound pain under standing on the next morning 
   after entering group were compared in the patients between the two groups. The 
   impact of the EA expectation was analyzed on the first postoperative exhaust 
   time, the first postoperative defecation time and the postoperative hospital stay 
   separately. RESULTS: The first postoperative exhaust time and the first 
   postoperative defecation time in the EA group were earlier than the conventional 
   treatment group (P<0.05), the postoperative hospital stay was shorter than the 
   conventional treatment group (P<0.05), and the rate of wound pain in the 
   postoperative standing was lower than the conventional treatment group (P<0.05). 
   EA expectation had no obvious correlation with the clinical therapeutic effect 
   (P>0.05). CONCLUSION: EA can relieve postoperative ileus symptoms, alleviate pain 
   and shorten hospital stay in the patients after laparotomy for gastrointestinal 
   cancer.
C1 Department of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
   Department of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
   Department of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
   Department of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
   Department of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JAN 14
PY 2022
VL 42
IS 1
BP 45
EP 8
DI 10.13703/j.0255-2930.20210125-0004 
PG -37
WC Acupuncture Points; Electroacupuncture; Gastrointestinal Neoplasms; Humans; Ileus; etiology; Laparotomy; adverse effects
UT PubMed:35025157
PM 35025157
DA 2022-01-14
ER

PT J
AU Enblom, A
   Tomasson, A
   Hammar, M
   Steineck, G
   Börjeson, S
AF Enblom, Anna
   Tomasson, Annica
   Hammar, Mats
   Steineck, Gunnar
   Börjeson, Sussanne
TI Pilot testing of methods for evaluation of acupuncture for emesis during 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
AB BACKGROUND: Many acupuncture studies are of weak methodological quality, possibly 
   due to lack of pilot testing. This pilot study tested design features, including 
   test of feasibility, compliance to treatment and data collection, level of 
   blinding success and the patients' potential perceived effects of the treatment, 
   in preparation for an efficacy study. METHOD: A modified single subject 
   experimental design was conducted. 10 cancer patients were randomised to verum 
   penetrating acupuncture or non-penetrating sham needles for 30 min 2-3 times/week 
   during radiotherapy over abdomen/pelvis. They answered test-retested emesis 
   questions (r=0.527-1.0) covering nausea, vomiting, use of antiemetics, wellbeing 
   and activities of daily living. RESULTS: Overall, the patients completed 98% of 
   the 345 emesis-questionnaire days and 101 of the 115 offered treatments. All 
   patients believed they received verum acupuncture. 10 patients experienced 
   antiemetic effects, seven relaxation, five pain-reduction and five experienced 
   sleep improvement. Two types of nausea questions showed absolute concordance 
   (r=1.0) (n of observations=456). Nausea was experienced by one of five verum 
   acupuncture treated patients (duration median 0% of the radiotherapy-days) and 
   four of five sham acupuncture treated patients (duration median 24% of the 
   radiotherapy-days). Patients experiencing nausea rated decreased wellbeing and 
   performance of daily activities compared to patients free from nausea. 
   CONCLUSIONS: All patients were blinded, complied with verum/sham treatments and 
   data-collection, and believed they had effects of the received treatment. The 
   methods for verum/sham treatment and data collection may thus be used in an 
   adequately powered randomised controlled study of the effect of acupuncture for 
   radiotherapy-induced emesis.
C1 Department of Medical and Health Sciences, Division of Nursing Science, Linköping University, Linköping, Sweden. anna.enblom@ki.se
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD APR 5
PY 2011
VL 29
IS 2
BP 94
EP 102
DI 10.1136/aim.2010.003384 
PG 8
WC Activities of Daily Living; Acupuncture Therapy; Adult; Aged; Aged, 80 and over; Case-Control Studies; Double-Blind Method; Female; Health Status; Humans; Male; Middle Aged; Nausea; prevention & control; Neoplasms; radiotherapy; Pain; prevention & control; Pilot Projects; Relaxation; Research Design; Sleep; Surveys and Questionnaires; Vomiting; prevention & control
UT PubMed:21460396
PM 21460396
DA 2011-04-05
ER

PT J
AU Tuck, CM
AF Tuck, Claire M
TI A 54-year-old woman with degenerative back pain.
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
AB Back pain is a common symptom: up to 70% of UK adults experience this symptom by 
   the age of 60 and most have moderate to severe pain. Back pain accounted for 12% 
   of consultations to traditional acupuncturists in 2001 and is one of the most 
   common reasons for consultation with an acupuncturist. This case report concerns 
   a 54-year-old woman with metastatic breast cancer and degenerative lower back 
   pain, which remained painful despite intensive pharmaceutical management and 
   facet joint injection and was ultimately successfully managed with two 30 min 
   acupuncture treatments 2 weeks apart, using eight points on the BL meridians. 
   Acupuncture treatment using tender points was later trialled for neuropathic pain 
   secondary to local recurrence in her mastectomy scar, however this was 
   unsuccessful and inpatient hospice admission for further intensive pharmaceutical 
   management was required.
C1 Strathcarron Hospice, Randolph Hill, Denny, Stirlingshire FK6 5HJ, UK. clairetuck@nhs.net
NR 0
TC 0
SN 
EI 0964-528
J9 Acupunct Med
PD MAR 31
PY 2010
VL 28
IS 1
BP 46
EP 8
DI 10.1136/aim.2009.000687 
PG -38
WC Acupuncture Analgesia; methods; Breast Neoplasms; complications; Chronic Disease; Female; Humans; Low Back Pain; etiology; Mastectomy; adverse effects; Meridians; Middle Aged; Pain, Intractable; etiology
UT PubMed:20351378
PM 20351378
DA 2010-03-31
ER

PT J
AU Cho, N
   Choi, Y
   Kim, H
   Yun, J
   Jun, H
   Yang, C
   Kim, S
   Leem, J
AF Cho, Nahyun
   Choi, Younkuk
   Kim, Heekyung
   Yun, Jeongmi
   Jun, Hyungsun
   Yang, Changsop
   Kim, Sungha
   Leem, Jungtae
TI Pain Treatment in Primary Care Through Eight Constitution Medicine: A 
SO Medicina (Kaunas, Lithuania)
LA English
DT Journal Article
DE acupuncture; healthy lifestyle; musculoskeletal pain; precision medicine; retrospective studies
AB Background and Objectives: Musculoskeletal pain is a global public health issue. 
   Eight Constitution Medicine (ECM), a type of East Asian Traditional Medicine, 
   offers personalized, minimally invasive treatment through Eight Constitution 
   Acupuncture (ECA) and Eight Constitution Lifestyle Intervention (ECLI). Despite 
   its clinical use, scientific evidence supporting ECM's effectiveness remains 
   limited. This study aimed to evaluate the effectiveness in treating 
   musculoskeletal pain in primary care settings. Materials and Methods: This 
   retrospective study analyzed medical records from three ECM clinics 
   (Gangnam-Shingwang, Yeson, and Yebon) between January 2018 and August 2023. A 
   total of 163 patients were included, with 44 providing follow-up data. Pain 
   intensity, quality of life, and functional outcomes were assessed using validated 
   instruments including the PainDETECT questionnaire, Korean Cancer Pain Assessment 
   Tool (KCPAT) somatic pain scores, EuroQol 5-Dimension 5-Level (EQ-5D-5L), Western 
   Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Oswestry 
   Disability Index (ODI), Neck Disability Index (NDI), and Shoulder Pain and 
   Disability Index (SPADI). Pre- and post-treatment scores were statistically 
   analyzed. Results: Significant decreases were observed in KCPAT somatic pain 
   scores (11.77 ± 4.77 to 9.77 ± 5.32) and significant improvements in EQ-5D-5L 
   scores (0.74 ± 0.12 to 0.80 ± 0.07). WOMAC and ODI scores also showed significant 
   improvements. However, the changes in the NDI, SPADI, and PainDETECT scores were 
   not statistically significant. No adverse events were reported. Conclusions: ECM, 
   through ECA and ECLI, may offer effective personalized treatment for 
   musculoskeletal pain, improving both pain intensity and quality of life. Despite 
   its small sample size and retrospective design, this study offers valuable 
   preliminary evidence for ECM. Further large-scale prospective studies are needed 
   to confirm these findings.
C1 Department of Diagnostics, College of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea.
   East-West Cancer Center, Cheonan Korean Medical Hospital, Daejeon University, 
   Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Gangnam-gu,Seoul 06355, Republic of Korea.
   Gangnam-Shingwang ECM Clinic, Seocho-gu, Seoul 06612, Republic of Korea.
   Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Gangnam-gu,Seoul 06355, Republic of Korea.
   Yebon ECM Clinic, Songpa-gu, Seoul 05510, Republic of Korea.
   Yeson ECM Clinic, Yangcheon-gu, Seoul 07999, Republic of Korea.
   Department of Diagnostics, College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea.
   KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
   Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
   Department of Diagnostics, College of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea.
   Research Center of Traditional Korean Medicine, College of Korean Medicine, 
   Department of Il-won Integrated Medicine, Wonkwang University Korean Medicine Hospital, 895, Muwang-ro, Iksan 54538, Republic of Korea.
NR 0
TC 0
SN 1648-914
EI 1010-660
J9 Medicina (Kaunas)
PD SEP 27
PY 2025
VL 61
IS 9
BP 
EP 
DI 10.3390/medicina61091564 
PG 0
WC Humans; Retrospective Studies; Female; Male; Middle Aged; Primary Health Care; statistics & numerical data; Republic of Korea; Pain Management; methods; Adult; Musculoskeletal Pain; therapy; Aged; Pain Measurement; methods; Quality of Life; psychology; Surveys and Questionnaires; Acupuncture Therapy; methods
UT PubMed:41010955
PM 41010955
DA 2025-09-27
ER

PT J
AU Wang, JY
   Gao, YH
   Qiao, LN
   Zhang, JL
   Rong, PJ
   Liu, JL
AF Wang, Jun-Ying
   Gao, Yong-Hui
   Qiao, Li-Na
   Zhang, Jin-Ling
   Rong, Pei-Jing
   Liu, Jun-Ling
TI [Electroacupuncture alleviated incisional neck pain possibly by suppressing TNF-α 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Dorsal horns of cervical spinal cord; Electroacupuncture; Incisional neck pain; Inflammatory cytokines
AB OBJECTIVE: To observe the effect of electroacupuncture (EA) on incisional pain 
   and expression of tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10) and 
   interleukin-4 (IL-4) of cervical dorsal part of spinal cord in rats with 
   incisional neck pain, so as to explore its analgesic mechanisms. METHODS: 
   Eighty-four male SD rats were randomly divided into normal control, model, 
   EA-Futu(LI18) and EA-Zusanli(ST36)-Yanglingquan(GB34, EA-ST36-GB34) groups (n=21 
   in each group). The incisional neck pain model was established by making a 
   longitudinal incision along the bilateral cervical thyroid regions and repeated 
   mechanical separation stimulation. For rats of the EA groups, EA (2 Hz/100 Hz, 1 
   mA) was applied to bilateral LI18 or ST36-GB34 for 30 min/ time during the 
   surgery, and 20 and 44 h after surgery, respectively. The thermal pain threshold 
   (TPT) of the incisional region was detected. The immunoactivity of TNF-α and 
   IL-10 of the dorsal portion of the cervical spinal cord (C2-C5) was detected by 
   immunofluorescence, and the expression of TNF-α, IL-10, IL-4 and IL-4 receptor 
   (IL-4R) mRNAs was determined by quantitative real-time PCR. RESULTS: Compared 
   with the normal group, the TPT of the incisional area was significantly decreased 
   at 4, 24 and 48 h after neck-incision (P<0.05), the levels of TNF-α mRNA, IL-10 
   mRNA and TNF-α IL-10 immunoactivity at 24 h were remarkably increased (P<0.05), 
   and the expression of IL-4R mRNA was considerably decreased at 24 h in the model 
   group (P<0.05). Following EA intervention, the TPT, and expression levels of IL-4 
   mRNA and IL-4R mRNA were significantly increased at 24 h after surgery in the 
   EA-LI18 group relevant to the model group (P<0.05), while the expression level of 
   TNF-α(coexpressed with microgliacytes) in the EA-LI18 group, and TNF-α mRNA 
   expression at 24 h in both EA-LI18 and EA-ST36-GB34 groups, as well as the 
   expression of IL-10 and IL-10 mRNA at 24 h in both EA-LI18 and EA-ST36-GB34 
   groups were significantly decreased (P<0.05). The effect of EA LI18 was 
   significantly superior to that of EA ST36-GB34 in up-regulating TPT and 
   expression of IL-4 mRNA and IL-4R mRNA at 24 h (P<0.05). CONCLUSION: EA of LI18 
   has an analgesic effect in incisional neck pain rats, which may be related to its 
   effect in down-regulating the expression of TNF-α, IL-10 and promoting IL-4 
   /IL-4R signaling in dorsal portions of the cervical spinal cord. The analgesic 
   effect of EA LI18 is better than that of EA ST36-GB34.
C1 Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD OCT 28
PY 2019
VL 44
IS 10
BP 703
EP 8
DI 10.13702/j.1000-0607.190355 
PG -695
WC Acupuncture Points; Animals; Electroacupuncture; Interleukin-4; Male; Neck Pain; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-4; Spinal Cord; Tumor Necrosis Factor-alpha
UT PubMed:31657158
PM 31657158
DA 2019-10-28
ER

PT J
AU Lee, DG
   Lee, SH
   Hwang, SW
   Kim, ES
   Eoh, W
AF Lee, Dong-Geun
   Lee, Sun-Ho
   Hwang, Sang-Won
   Kim, Eun-Sang
   Eoh, Whan
TI Myositis ossificans in the paraspinal muscles of the neck after acupuncture: a 
SO The spine journal : official journal of the North American Spine Society
LA English
DT Journal Article
DE Acupuncture; Cervical spine; Myositis ossificans
AB BACKGROUND CONTEXT: Although traumatic myositis ossificans (MO) has been reported 
   occasionally, MO of paraspinal muscles has been rarely seen in the cervical spine 
   after minor injury. This is difficult to distinguish from benign and malignant 
   soft lesions in cases of a lack of definite trauma history. PURPOSE: We report a 
   case of MO in the cervical paraspinal muscle after acupuncture and describe 
   methods for diagnosis and proper treatment, including classification, etiology, 
   and radiologic and histologic features. STUDY DESIGN: Case report. METHODS: A 
   26-year-old woman complained of posterior neck pain that had began 2 months 
   earlier and neck swelling after acupuncture. No abnormal finding existed on the 
   X-ray except soft tissue swelling. Magnetic resonance imaging was evaluated 
   because of constant neck pain. To obtain more accurate assessment, computed 
   tomography-guided biopsy was performed and a diagnosis of MO was made. RESULTS: 
   The patient was conservatively treated through rest and analgesics. Posterior 
   neck pain and swelling improved for a several months. The hyperdensity was 
   comparable with the bony density, and the size of the calcified lesion on X-ray 
   diminished until the last follow-up. CONCLUSIONS: Myositis ossificans that can 
   occur after acupuncture should be recognized as a possible cause of persistent 
   neck pain and swelling despite no definite trauma after thorough evaluation of 
   the neoplasm and infection.
C1 Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.
NR 0
TC 0
SN 1878-163
EI 
J9 Spine J
PD MAR 26
PY 2013
VL 13
IS 7
BP e9
EP e12
DI 10.1016/j.spinee.2013.02.012 
PG 1
WC Acupuncture Therapy; adverse effects; Adult; Female; Humans; Myositis Ossificans; diagnosis; Neck Muscles; diagnostic imaging; Neck Pain; diagnostic imaging; Paraspinal Muscles; diagnostic imaging; Radiography
UT PubMed:23523436
PM 23523436
DA 2013-03-26
ER

PT J
AU Chen, CY
   Lin, YQ
   Wang, ZY
   He, LL
   Wang, X
AF Chen, Cai-Yi
   Lin, Yuan-Quan
   Wang, Zhang-Ying
   He, Ling-Ling
   Wang, Xuan
TI [Effects of different intensities of electroacupuncture and manual acupuncture at 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acute inflammatory visceral pain; Electroacupuncture; Manual acupuncture; Shangjuxu(ST37); α7nAChR/PI3K/AKT signaling pathway
AB OBJECTIVES: To compare the effects of electroacupuncture (EA) and manual 
   acupuncture (MA) at different stimulation intensities on acute inflammatory 
   visceral pain, and to analyze their mechanisms underlying relief of inflammatory 
   visceral pain mediated by α7 nicotinic acetylcholine receptor 
   (α7nAChR)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling 
   pathway. METHODS: Male SD rats were randomly divided into normal control, 
   visceral pain model, EA 1 mA, EA 2 mA, EA 3 mA, EA 4 mA, EA 6 mA, and MA groups 
   (with the same frequency as EA, 2 times/s, for 2 min), with 12 rats in each 
   group. The acute inflammatory visceral pain model was established by intracolonic 
   instillation of 2% acetic acid. EA (2 Hz, 1, 2, 3, 4, 6 mA) or MA (120 
   twirlings/min, with the needle rotated at a magnitude of about 90°-180°) was 
   applied to the right "Shangjuxu" (ST37) for 2 min. The abdominal withdrawal 
   reflex (AWR) score and external oblique muscle electromyogram amplitude were used 
   to assess the visceral pain reaction. Histopathological changes of the colonic 
   mucosal tissue were detected by H.E. staining. For observing the involvement of 
   colonic α7nAChR in visceral pain relief of both EA and MA, intraperitoneal 
   injection of methylaconitine (MLA, α7nAChR blocker, 4 mg/kg) was given to rats of 
   MA+MLA and EA 2 mA+MLA groups (with 6 rats in each group) before each 
   intervention. The contents of serum tumor necrosis factor-α(TNF-ɑ) and 
   interleukin-1β(IL-1β) were detected by enzyme-linked immunosorbent assay (ELISA). 
   The expression levels of α7nAChR, PI3K and AKT in the colon tissue were detected 
   by Western blot. RESULTS: In comparison with the normal control group, both the 
   AWR scores and the amplitude of EMG at colorectal dilation (CRD) pressure of 20, 
   40, 60 and 80 mmHg were significantly increased in the model group (P<0.05). 
   Compared with the model group, both the AWR scores and the amplitude of EMG at 
   CRD pressure of 20, 40, 60 and 80 mmHg were significantly decreased in the EA 1 
   mA, EA 2 mA and MA groups (P<0.05), rather than in the EA 3 mA, EA 4 mA and EA 6 
   mA groups, suggesting that the higher stimulation intensity of EA had no 
   analgesic effect. H.E. staining showed slightly hyperemic and edematous injury of 
   the colonic mucosa tissue, with obvious inflammatory infiltration and abnormal 
   morphological changes in the model group, which was obviously milder in the 
   injury in the MA and EA 1 mA, EA 2 mA groups, rather than in the EA 3 mA, 4 mA 
   and 6 mA groups. In comparison with the normal control group, the contents of 
   serum TNF-ɑ and IL-1β, and expression levels of PI3K and AKT proteins in colon 
   were significantly increased (P<0.05), and the expression of α7nAChR protein was 
   remarkably down-regulated (P<0.05) in the model group. Compared with the model 
   group, the contents of serum TNF-ɑ and IL-1β, and the expression levels of PI3K 
   and AKT proteins were strikingly down-regulated (P<0.05), and the expression of 
   α7nAChR was considerably up-regulated (P<0.05) in both EA 2 mA and MA groups. 
   Moreover, the effects of reducing the corresponding AWR scores at various CRD 
   pressure levels, serum TNF-α and IL-1β contents, and the protein expressions of 
   PI3K and AKT in colon, as well as increasing the protein expression of α7nAChR in 
   colon in rats of MA and EA 2 mA groups can be inhibited by MLA (P<0.05), a 
   blocker of α7nAChR. CONCLUSIONS: Both MA and 2 mA EA (not 3, 4, 6 mA EA) 
   stimulation of ST37 have a similar analgesic effect in acute inflammatory 
   visceral pain rats, which may be related to their function in suppressing the 
   activities of α7nAChR/PI3K/AKT signaling pathway.
C1 College of Acupuncture and Moxibustion, Fujian University of Chinese Medicine, Fuzhou 350122, China.
   College of Acupuncture and Moxibustion, Fujian University of Chinese Medicine, Fuzhou 350122, China.
   College of Acupuncture and Moxibustion, Fujian University of Chinese Medicine, Fuzhou 350122, China.
   College of Acupuncture and Moxibustion, Fujian University of Chinese Medicine, Fuzhou 350122, China.
   College of Adult Education, Fujian University of Chinese Medicine, Fuzhou 350122. 674700301@qq.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD DEC 25
PY 2025
VL 50
IS 12
BP 1365
EP 1375
DI 10.13702/j.1000-0607.20250327 
PG 10
WC Animals; Male; Electroacupuncture; Rats, Sprague-Dawley; Acupuncture Points; Rats; Proto-Oncogene Proteins c-akt; genetics; alpha7 Nicotinic Acetylcholine Receptor; genetics; Humans; Signal Transduction; Visceral Pain; therapy; Phosphatidylinositol 3-Kinases; genetics; Acupuncture Therapy
UT PubMed:41443910
PM 41443910
DA 2025-12-25
ER

PT J
AU Gao, YH
   Wang, JY
   Han, YJ
   Liu, JL
AF Gao, Yong-Hui
   Wang, Jun-Ying
   Han, Yan-Jing
   Liu, Jun-Ling
TI [Spinal cord Toll like receptor 4 and its co-stimulatory molecule heat shock 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acupuncture analgesia; Chronic neuropathic pain; Heat shock protein 90；Microglia; Neuron; Toll-like receptor 4
AB OBJECTIVE: To observe the effect of electroacupuncture (EA) on the expression of 
   Toll like receptor 4(TLR4)and heat shock protein 90(HSP90) in the spinal cord of 
   rats with chronic constriction injury (CCI) of sciatic nerve, so as to explore 
   the mechanism of spinal cord TLR4 and HSP90 in alleviating chronic neuropathic 
   pain by EA. METHODS: Male Wistar rats were randomized into control, model, EA, 
   HSP90 inhibitor (inhibitor) and EA+ inhibitor groups (n=10 in each group). The 
   neuropathic pain model was established by ligature of the right sciatic nerve to 
   induce CCI. EA (1 mA，2 Hz/15 Hz)was applied at bilateral "Zusanli"(ST36) and 
   "Yanglingquan"(GB34) for 30 min, once daily for 5 days. Rats of the inhibitor and 
   EA+inhibitor groups were given a subcutaneous injection of HSP90 inhibitor 
   geldanamycin (50 μg/kg) at the neck before daily EA. The paw withdrawal latency 
   (PWL) of the bilateral hind-limbs was detected by using an algesia-detector. The 
   contents of interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) in the 
   lumbar spinal cord (L2-L4) tissue were detected by enzyme-linked immunosorbent 
   assay. The relative expression levels of HSP90 and TLR4 proteins in the lumbar 
   spinal cord (L2-L4) were detected using Western blot and immunofluorescence 
   double labeling, respectively. RESULTS: Following CCI, a strong thermal 
   hyperalgesia, an apparent up-regulation of expression of HSP90 and TLR4 proteins 
   and TLR4 in microglia, and increasing levels of IL-1β and TNF-α in the spinal 
   cord were induced in the model group relevant to the control group 
   (P<0.01，P<0.05). Five sessions of EA intervention or inhibitor injection 
   significantly attenuated hyperalgesia, reversed the increase of IL-1β and TNF-α, 
   and down-regulated the expression of TLR4 in microglia (P<0.05). Compared with 
   the model group, the expression of HSP90 was further increased (P<0.05), and 
   those of TLR4 in microglia and neurons were significantly decreased and 
   increased, respectively in the EA group (P<0.05). Compared with the EA group, the 
   levels of PWLD,TLR4 and HSP90 expression, and the proportions of neuronal nuclei 
   antigen（NeuN） and TLR4, and ionized calcium binding adapter molecule （Iba1） and 
   TLR4 co-expressed cells were significantly decreased in the inhibitor group and 
   EA+inhibitor group (P<0.05). The proportion of NeuN and TLR4 co-expression cells 
   in the EA+inhibitor group was significantly higher than that of the inhibitor 
   group (P<0.05). CONCLUSION: EA stimulation of ST36 and GB34 can alleviate thermal 
   hyperalgesia in CCI rats, which is closely associated with its effect in 
   regulating the expression of TLR4 in the spinal cord neurons and microglia. HSP90 
   in the spinal cord may be a co-stimulatory molecule for EA induced relief of 
   neuropathic pain by regulating TLR4.
C1 Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD SEP 25
PY 2021
VL 46
IS 9
BP 735
EP 41
DI 10.13702/j.1000-0607.201103 
PG -694
WC Animals; Electroacupuncture; Heat-Shock Proteins; Male; Neuralgia; genetics; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spinal Cord; Toll-Like Receptor 4; genetics
UT PubMed:34558238
PM 34558238
DA 2021-09-25
ER

PT J
AU de, Matos NMP
   Pach, D
   Xing, JJ
   Barth, J
   Beyer, LE
   Shi, X
   Kern, A
   Lukic, N
   Ettlin, DA
   Brügger, M
   Witt, CM
AF de Matos, Nuno M P
   Pach, Daniel
   Xing, Jing Jing
   Barth, Jürgen
   Beyer, Lara Elena
   Shi, Xuemin
   Kern, Alexandra
   Lukic, Nenad
   Ettlin, Dominik A
   Brügger, Mike
   Witt, Claudia M
TI Evaluating the Effects of Acupuncture Using a Dental Pain Model in Healthy 
SO The journal of pain
LA English
DT Journal Article
DE Acupuncture; Chinese traditional; Medicine; nociception; pain; toothache
AB Acupuncture is a complementary and nonpharmacological intervention that can be 
   effective for the management of chronic pain in addition to or instead of 
   medication. Various animal models for neuropathic pain, inflammatory pain, 
   cancer-related pain, and visceral pain already exist in acupuncture research. We 
   used a newly validated human pain model and examined whether acupuncture can 
   influence experimentally induced dental pain. For this study, we compared the 
   impact of manual acupuncture (real acupuncture), manual stimulation of a needle 
   inserted at nonacupuncture points (sham acupuncture) and no acupuncture on 
   experimentally induced dental pain in 35 healthy men who were randomized to 
   different sequences of all 3 interventions in a within-subject design. BORG CR10 
   pain ratings and autonomic responses (electrodermal activity and heart rate 
   variability) were investigated. An initial mixed model with repeated measures 
   included preintervention pain ratings and the trial sequence as covariates. The 
   results showed that acupuncture was effective in reducing pain intensity when 
   compared to no acupuncture (β = -.708, P = .002), corresponding to a medium 
   Cohen's d effect size of .56. The comparison to the sham acupuncture revealed no 
   statistically significant difference. No differences in autonomic responses 
   between real and sham acupuncture were found during the intervention procedures. 
   PERSPECTIVE: This study established a dental pain model for acupuncture research 
   and provided evidence that experimentally induced dental pain can be influenced 
   by either real acupuncture or manual stimulation of needles at nonacupuncture 
   points. The data do not support that acupoint specificity is a significant factor 
   in reducing experimental pain.
C1 Institute for Complementary and Integrative Medicine, University of Zurich and University Hospital Zurich, Zurich, Switzerland
   Clinic of Cranio-Maxillofacialand Oral Surgery, Center of Dental Medicine, University of Zurich, Zurich,Switzerland.
   Institute for Complementary and Integrative Medicine, University of Zurich and University Hospital Zurich, Zurich, Switzerland
   Charité - UniversitätsmedizinBerlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zuBerlin, and Berlin Institute of Health, Institute for Social Medicine,Epidemiology and Health Economics, Berlin, Germany. 
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   Institute for Complementary and Integrative Medicine, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
   Institute for Complementary and Integrative Medicine, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
   Institute for Complementary and Integrative Medicine, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
   Institute for Complementary and Integrative Medicine, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
   Clinic of Cranio-Maxillofacial and Oral Surgery, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
   Clinic of Cranio-Maxillofacial and Oral Surgery, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
   Clinic of Cranio-Maxillofacial and Oral Surgery, Center of Dental Medicine, University of Zurich, Zurich, Switzerland
   Institute for Biomedical Engineering,ETH Zurich and University of Zurich, Zurich, Switzerland.
   Institute for Complementary and Integrative Medicine, University of Zurich and University Hospital Zurich, Zurich, Switzerland
   Charité - UniversitätsmedizinBerlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zuBerlin, and Berlin Institute of Health, Institute for Social Medicine,Epidemiology and Health Economics, Berlin, Germany
   Center for IntegrativeMedicine, University of Maryland School of Medicine Baltimore, Baltimore,Maryland.
EM aniel.pach@uzh.ch
NR 0
TC 0
SN 1528-844
EI 
J9 J Pain
PD SEP 16
PY 2019
VL 21
IS 3-4
BP 440
EP 454
DI 10.1016/j.jpain.2019.08.013 
PG 14
WC Acupuncture Therapy; Adult; Cross-Over Studies; Galvanic Skin Response; physiology; Heart Rate; physiology; Humans; Male; Medicine, Chinese Traditional; Outcome Assessment, Health Care; Pain Measurement; Placebos; Toothache; therapy; Young Adult
UT PubMed:31521794
PM 31521794
DA 2019-09-16
ER

PT J
AU Qi, X
   Chen, L
   Zhang, X
   Han, M
   He, W
   Su, Y
   Wang, X
   Jing, X
   Zhu, B
AF Qi, Xuezhi
   Chen, Lizhen
   Zhang, Xiaoning
   Han, Mingjuan
   He, Wei
   Su, Yangshuai
   Wang, Xiaoyu
   Jing, Xianghong
   Zhu, Bing
TI [Distribution of algesia sensitized acupoints in the patients of intestinal 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupoint sensitization; intestinal cancer; pressure-pain threshold
AB OBJECTIVE: To judge whether algesia sensitization of some acupoints is existed 
   and whether the acupoint algesia sensitization area is expanded in the patients 
   of intestinal cancer. METHODS: Totally, 30 patients of intestinal cancer and 30 
   healthy subjects were included. The electronic Von Fray was used to determine the 
   pressure-pain thresholds at 13 acupoints relevant with gastrointestinal disorders 
   and the reference points at the sites 1 cun and 2 cun lateral to those points as 
   well as the sites at the corresponding nerve segments. Compared with the 
   pressure-pain thresholds at the reference points of the different segments, the 
   relative value was calculated. The changes were analyzed in the pressure-pain 
   thresholds at the relevant acupoints on the body surface in the patients of 
   intestinal cancer as compared with the relative pressure-pain thresholds in the 
   healthy volunteers. RESULTS: The pressure-pain thresholds at Zusanli (ST 36), 
   Shangjuxu (ST 37), Xiajuxu (ST 39), Quchi (LI 11) and Dachangshu (BL 25) in the 
   patients of intestinal cancer were all significantly reduced as compared with 
   those of the healthy subjects (P<0.05, P<0.01, P<0.001). At the non-acupoint 
   sites 1 cun and 2 cun lateral to those acupoints as well as at the sites of the 
   same segments, the pressure-pain thresholds were reduced significantly as 
   compared with the control group (P<0.05, P<0.01, P<0.001). Particularly, the 
   sensitization zone of Yinlingquan (SP 9) focused on the acupoint, the site 1 cun 
   lateral to it as well as the non-acupoint sites of the same segments (P<0.01, 
   P<0.001). CONCLUSION: The acupoint sensitization is displayed at Zusanli (ST 36), 
   Shangjuxu (ST 37), Xiajuxu (ST 39), Quchi (LI 11), Dachangshu (BL 25) and 
   Yinlingquan (SP 9) and the sensitization area is expended in the patients of 
   intestinal cancer.
C1 Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JAN 23
PY 2018
VL 37
IS 9
BP 963
EP 6
DI 10.13703/j.0255-2930.2017.09.014 
PG -957
WC Acupuncture Analgesia; methods; Acupuncture Points; Cancer Pain; physiopathology; Case-Control Studies; Humans; Intestinal Neoplasms; physiopathology; Meridians; Pain Threshold
UT PubMed:29354918
PM 29354918
DA 2018-01-23
ER

PT J
AU Chen, ZW
   Xu, T
   Yin, ZH
   Li, QF
   Shu, YJ
   Zhou, XL
   Zhao, L
   Sun, MS
   Liang, FR
AF Chen, Zi-Wen
   Xu, Tao
   Yin, Zi-Han
   Li, Qi-Fu
   Shu, Yun-Jie
   Zhou, Xue-Li
   Zhao, Ling
   Sun, Ming-Sheng
   Liang, Fan-Rong
TI Electroacupuncture for chemotherapy-induced gastrointestinal symptoms in 
SO International journal of colorectal disease
LA English
DT Journal Article
DE Chemotherapy; Colorectal cancer; Electroacupuncture; Gastrointestinal toxicity; Randomized controlled trial
AB BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer-related 
   mortality globally. While chemotherapy remains a cornerstone of CRC treatment, 
   gastrointestinal (GI) toxicity-manifesting as abdominal pain, diarrhea, 
   constipation, and reflux-affects 40%-100% of patients, severely impairing quality 
   of life. Despite the prevalence of these symptoms, there is a lack of effective 
   non-pharmacological interventions. This study aims to evaluate the efficacy of 
   electroacupuncture (EA) in alleviating chemotherapy-induced GI dysfunction in CRC 
   patients. METHODS: In this multicenter, three-arm, randomized controlled trial 
   (RCT), 231 CRC patients with post-chemotherapy GI symptoms will be centrally 
   randomized to EA plus standard care, sham acupuncture (SA) plus standard care, or 
   standard care alone. The EA and SA groups will receive three 30-min sessions over 
   consecutive days, delivered by certified acupuncturists (EA: LI11, PC6, ST36 and 
   ST37 with electrical stimulation; SA: non-acupoints with blunt-tip needles 
   without stimulation). The primary outcome is the change in Gastrointestinal 
   Symptom Rating Scale (GSRS) total scores from baseline to post-treatment (day 3). 
   Secondary outcomes include GSRS subscale scores, Functional Assessment of Cancer 
   Therapy-Colorectal (FACT-C) scores, and Self-Rating Anxiety Scale/Self-Rating 
   Depression Scale (SAS/SDS) scores. All outcomes will be assessed at baseline 
   (T0), post-intervention (T1: day 3), and follow-up (T2: day 10). Statistical 
   analysis will employ intention-to-treat linear mixed-effects models. CONCLUSION: 
   This multicenter RCT is designed to generate high-quality evidence on the 
   comprehensive efficacy of EA in addressing chemotherapy-induced GI toxicity in 
   CRC patients. If proven effective, EA could provide a safe, non-pharmacological 
   adjunct to standard care, helping to reduce symptom burden and improve patient 
   adherence to chemotherapy. Trial registration ChiCTR2200062317. Registered on 1 
   August 2022.
C1 Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China.
   Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, 
   Research Department, Sichuan Orthopedic Hospital, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China.
   Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, 
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China.
   Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, 
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China. acuresearch@126.com.
   Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, 
NR 0
TC 0
SN 1432-126
EI 0179-195
J9 Int J Colorectal Dis
PD OCT 27
PY 2025
VL 40
IS 1
BP 221
EP 221
DI 10.1007/s00384-025-05008-3 
PG 0
WC Humans; Electroacupuncture; Colorectal Neoplasms; drug therapy; Multicenter Studies as Topic; Gastrointestinal Diseases; therapy; Randomized Controlled Trials as Topic; Antineoplastic Agents; adverse effects; Female; Treatment Outcome; Male; Middle Aged; Quality of Life; Adult; Aged
UT PubMed:41144022
PM 41144022
DA 2025-10-27
ER

PT J
AU Arriaga-Pizano, L
   Gómez-Jiménez, DC
   Flores-Mejía, LA
   Pérez-Cervera, Y
   Solórzano-Mata, CJ
   López-Macías, C
   Isibasi, A
   Torres-Rosas, R
AF Arriaga-Pizano, Lourdes
   Gómez-Jiménez, Daniel Cuauhtémoc
   Flores-Mejía, Luis Angel
   Pérez-Cervera, Yobana
   Solórzano-Mata, Carlos Josué
   López-Macías, Constantino
   Isibasi, Armando
   Torres-Rosas, Rafael
TI Low back pain in athletes can be controlled with acupuncture by a 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE acupuncture; low back pain; non-steroidal anti-inflammatory drugs; pain management; physical therapy; sports medicine
AB BACKGROUND: Activation of the sympathetic nervous system attenuates inflammation 
   via catecholamines. Recent evidence has shown that electroacupuncture (EA) 
   activates neuronal networks involved in the release of dopamine and 
   norepinephrine that control systemic inflammation. In muscle, catecholamines are 
   related to cyclic adenosine monophosphate (cAMP). This signaling molecule has 
   been implicated in recovery from sustained contractile activity, which may induce 
   muscular pain, such as that which occurs during low back pain (LBP). OBJECTIVE: 
   Our aim was to evaluate the effects of EA used for the control of LBP on the 
   activation of the sympathetic nervous system in a randomized controlled clinical 
   trial in athletes. METHODS: Two groups of athletes with acute or chronic low back 
   pain were studied. EA, sham EA and pharmacological treatment (diclofenac sodium) 
   were evaluated. The outcome measures included a pain score represented by a 
   visual analogue scale (VAS) and serum levels of catecholamines quantified by 
   enzyme-linked immunosorbent assay. In addition, blood was collected into chilled 
   heparin tubes, placed in 96-well cell culture plates and incubated with an equal 
   volume of Roswell Park Memorial Institute (RPMI) medium, with lipopolysaccharide 
   (LPS) alone or with catecholamines. Tumor necrosis factor (TNF)-α levels in the 
   supernatants were analyzed. RESULTS: The results indicated that the initial pain 
   ratings did not differ between the groups analyzed. EA induced epinephrine 
   secretion but not norepinephrine or dopamine secretion. Although EA and 
   pharmacological treatment did not differ in terms of pain relief, in vitro 
   epinephrine and norepinephrine reduced TNF-α production in response to LPS 
   stimuli. CONCLUSION: EA activates the sympathetic nervous system and induces the 
   release of epinephrine, which could ameliorate inflammation and protect muscular 
   tissue in addition to relieving pain.
C1 Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS),Ciudad de México, Mexico.
   Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Ciudad de México, México.
   Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS),Ciudad de México, Mexico.
   "Laboratorio de Inmunología, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontología, Universidad Autónoma "Benito Juárez" deOaxaca, Oaxaca, México.
   Centro de Investigación UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad 
   "Laboratorio de Inmunología, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontología, Universidad Autónoma "Benito Juárez" deOaxaca, Oaxaca, México.
   Centro de Investigación UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad 
   Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS),Ciudad de México, Mexico.
   Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS),Ciudad de México, Mexico.
   "Laboratorio de Inmunología, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontología, Universidad Autónoma "Benito Juárez" deOaxaca, Oaxaca, México.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD MAY 21
PY 2020
VL 38
IS 6
BP 388
EP 395
DI 10.1177/0964528420912251 
PG 7
WC Adolescent; Adult; Athletes; statistics & numerical data; Catecholamines; metabolism; Electroacupuncture; Humans; Low Back Pain; metabolism; Male; Treatment Outcome; Young Adult
UT PubMed:32429680
PM 32429680
DA 2020-05-21
ER

PT J
AU Chen, LJ
   Ye, LT
   Wang, JY
   Qiu, X
AF Chen, Li-Juan
   Ye, Li-Tian
   Wang, Jia-Yu
   Qiu, Xuan
TI A Narrative Review of the Efficacy of Acupuncture in Chemotherapy-Induced 
SO Journal of evidence-based integrative medicine
LA English
DT Review
DE acupuncture; cancer; chemotherapy-induced peripheral neuropathy; integrative medicine; neuropathic pain
AB ObjectiveThis review synthesizes current evidence on the efficacy of acupuncture 
   in managing chemotherapy-induced peripheral neuropathy (CIPN) in cancer patients, 
   focusing on its mechanisms, clinical applications, and future research 
   directions.MethodsThis narrative review synthesizes and critically appraises 
   findings from randomized controlled trials (RCTs), meta-analyses, and preclinical 
   studies, evaluating acupuncture's impact on pain relief, neurological function, 
   and quality of life. Key databases were searched for studies published up to 
   2024.ResultsNineteen RCTs (n = 1174) demonstrated significant improvements in 
   CIPN symptoms with acupuncture, particularly in reducing neuropathic pain (eg, 
   via endogenous opioid modulation) and enhancing sensory function (eg, 
   BDNF-mediated neuroplasticity). Optimal protocols involved 2-3 sessions/week for 
   4-12 weeks, targeting acupoints such as ST36 and LI4. Acupuncture outperformed 
   pharmacotherapy (eg, duloxetine) in safety and patient-reported 
   outcomes.ConclusionAcupuncture is a promising adjunctive therapy for CIPN, 
   offering multimodal mechanisms and clinical benefits. Standardization of 
   protocols and further high-quality RCTs are needed to strengthen evidence and 
   guide integration into oncology care.
C1 Department of Oncology, Qingdao Haici Hospital Affiliated to Qingdao University, Qingdao, China. RINGGOLD: 155177
   Department of Faculty Surgery, St. Petersburg State University, Saint Petersburg, Russia. RINGGOLD: 48544
   Department of Surgery, Shandong Linglong Yingcheng Hospital, Yantai, China. RINGGOLD: 580717
   Department of Faculty Surgery, St. Petersburg State University, Saint Petersburg, Russia. RINGGOLD: 48544
   Department of Surgery, Shandong Linglong Yingcheng Hospital, Yantai, China. 
NR 0
TC 0
SN 2515-690
EI 
J9 J Evid Based Integr Med
PD JAN 2
PY 2026
VL 31
IS 
BP 2515690X251411764
EP 2515690X251411764
DI 10.1177/2515690X251411764 
PG 1
WC Humans; Acupuncture Therapy; methods; Neoplasms; drug therapy; Peripheral Nervous System Diseases; therapy; Antineoplastic Agents; adverse effects; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:41481481
PM 41481481
DA 2026-01-02
ER

PT J
AU Qu, SY
   Wang, HZ
   Hu, QQ
   Ma, YQ
   Kang, YR
   Ma, LQ
   Li, X
   Chen, LH
   Liu, BY
   Shao, XM
   Liu, BY
   Du, JY
   Liang, Y
   Zhao, HL
   Jiang, YL
   Fang, JQ
   He, XF
AF Qu, Si-Ying
   Wang, Han-Zhi
   Hu, Qun-Qi
   Ma, Yi-Qi
   Kang, Yu-Rong
   Ma, Li-Qian
   Li, Xiang
   Chen, Lu-Hang
   Liu, Bo-Yu
   Shao, Xiao-Mei
   Liu, Bo-Yi
   Du, Jun-Ying
   Liang, Yi
   Zhao, Hong-Li
   Jiang, Yong-Liang
   Fang, Jian-Qiao
   He, Xiao-Fen
TI Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the 
SO Purinergic signalling
LA English
DT Journal Article
DE Diabetic neuropathic pain; Electroacupuncture; Microglia; P2X4R; Spinal cord
AB Diabetic neuropathic pain (DNP) is a common and destructive complication of 
   diabetes mellitus. The discovery of effective therapeutic methods for DNP is 
   vitally imperative because of the lack of effective treatments. Although 2 Hz 
   electroacupuncture (EA) was a successful approach for relieving DNP, the 
   mechanism underlying the effect of EA on DNP is still poorly understood. Here, we 
   established a rat model of DNP that was induced by streptozotocin (STZ) 
   injection. P2X4R was upregulated in the spinal cord after STZ-injection. The 
   upregulation of P2X4R was mainly expressed on activated microglia. Intrathecal 
   injection of a P2X4R antagonist or microglia inhibitor attenuated STZ-induced 
   nociceptive thermal hyperalgesia and reduced the overexpression of brain-derived 
   neurotrophic factor (BDNF), interleukin-1β (IL-1β) and tumor necrosis factor-α 
   (TNF-α) in the spinal cord. We also assessed the effects of EA treatment on the 
   pain hypersensitivities of DNP rats, and further investigated the possible 
   mechanism underlying the analgesic effect of EA. EA relieved the hyperalgesia of 
   DNP. In terms of mechanism, EA reduced the upregulation of P2X4R on activated 
   microglia and decreased BDNF, IL-1β and TNF-α in the spinal cord. Mechanistic 
   research of EA's analgesic impact would be beneficial in ensuring its prospective 
   therapeutic effect on DNP as well as in extending EA's applicability.
C1 Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Department of TCM Gynecology, Hangzhou Hospital of Traditional Chinese Medicine 
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of 
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of 
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of 
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of 
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of 
   Department of TCM Gynecology, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, 310000, China.
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China. jyl2182@126.com.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of 
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China. fangjianqiao7532@163.com.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of 
   Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China. zjhxf1986@163.com.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of 
NR 0
TC 0
SN 1573-954
EI 1573-953
J9 Purinergic Signal
PD OCT 23
PY 2023
VL 21
IS 4
BP 533
EP 547
DI 10.1007/s11302-023-09972-9 
PG 14
WC Animals; Electroacupuncture; methods; Microglia; metabolism; Receptors, Purinergic P2X4; metabolism; Diabetic Neuropathies; metabolism; Rats; Male; Rats, Sprague-Dawley; Neuroinflammatory Diseases; metabolism; Neuralgia; metabolism; Diabetes Mellitus, Experimental; metabolism; Spinal Cord; metabolism
UT PubMed:37870716
PM 37870716
DA 2023-10-23
ER

PT J
AU Pan, ZQ
   Chen, M
   Jia, YP
AF Pan, Zhi-Qiang
   Chen, Ming
   Jia, Yun-Peng
TI [Clinical study of type Ⅲ prostatitis treated with "warming and promoting 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Extracorporeal shock wave; Type Ⅲ prostatitis; “Warming and promoting technique” of acupuncture
AB OBJECTIVE: To observe the clinical curative effect of wentongzhenfa (warming and 
   promoting technique of acupuncture) combined with extracorporeal shock wave in 
   treatment of type Ⅲ prostatitis. METHODS: A total of 96 patients with type Ⅲ 
   prostatitis were randomly divided into an observation group (48 cases) and a 
   control group (48 cases). In the control group, the extracorporeal shock wave was 
   combined with even-needling technique of acupuncture at Guanyuan (CV4), Mingmen 
   (GV4), Zhongji (CV3), Zusanli (ST36), etc. In the observation group, the 
   extracorporeal shock wave was combined with "warming and promoting technique" of 
   acupuncture at the same acupoints as the control group. The treatment lasted 30 
   min each time, once daily in either group. There were 2 days of interval after 
   consecutive treatment for 5 days. Totally, the duration of treatment was 1 month 
   in two groups. The clinical curative effect was assessed after treatment. Before 
   and after treatment, the changes in the concentrations of tumor nerosis factor-α 
   (TNF-α), interleukin-1β(IL-1β) and IL-6 in prostatic fluid were determined; and 
   the symptoms were scored, i.e. frequent, urgent and burning painful urine, 
   difficulty in urination, dribbling urine, distending pain in perineum, bitter 
   taste and dry mouth, and scrotal dampness. The changes in the scores of National 
   Institute of Health chronic prostatitis symptom index (NIH-CPSI), international 
   index of erectile function (IIEF), visual analogue scale (VAS) were evaluated 
   befroe and after treatment. Successively, before treatment, after treatment, as 
   well as 1 and 3 months after treatment, the quality of life was evaluated by 
   Karnofsky in the patients of two groups. RESULTS: After treatment, the total 
   effective rate was 89.6% (43/48) in the observation group, higher than 70.8% 
   (34/48) in the control group (P<0.05). Compared with those before treatment, the 
   concentrations of TNF-α and IL-1β in the prostatic fluid were all decreased 
   (P<0.05) and the concentration of IL-6 was increased (P<0.05), the scores of 
   symptoms, NIH-CPSI, IIEF and VAS were all reduced (P<0.05) in two groups. The 
   changes of the above indexes were more obvious in the observation group than 
   those in the control group (P<0.05). After treatment and 1 and 3 months after 
   treatment, Karnofsky scores all increased (P<0.05) in two groups，and the 
   increases were more significant in the observation group (P<0.05). CONCLUSION: 
   "Warming and promoting technique" of acupuncture combined with extracorporeal 
   shock wave promotes the elimination of local inflammatory factors, relieves 
   clinical symptoms, improves the quality of life, as well as has a satisfactory 
   short-term and medium-term curative effect on type Ⅲ prostatitis.
C1 Department of Urinary Surgery, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China.
   Department of Urinary Surgery, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China.
   Department of Urinary Surgery, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD APR 30
PY 2022
VL 47
IS 4
BP 343
EP 8
DI 10.13702/j.1000-0607.20210278 
PG -335
WC Acupuncture Therapy; methods; Chronic Disease; Humans; Interleukin-6; Male; Pain; Prostatitis; therapy; Quality of Life; Tumor Necrosis Factor-alpha
UT PubMed:35486014
PM 35486014
DA 2022-04-30
ER

PT J
AU Yu, T
   Liu, H
   Liu, Z
   Chen, R
   Xie, D
AF Yu, Ting
   Liu, Huawei
   Liu, Zuqin
   Chen, Rixin
   Xie, Dingyi
TI [Heat-sensitive moxibustion assisted in palliative treatment to improve the 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE heat-sensitive moxibustion; immunologic function; malignant tumor, elderly; palliative treatment; quality of life
AB OBJECTIVE: To observe the effect of heat-sensitive moxibustion on the quality of 
   life in the elderly patients with malignant tumor based on palliative treatment. 
   METHODS: A total of 100 elderly patients with malignant tumor were randomly 
   divided into an observation group (50 cases, 3 cases dropped out) and a control 
   group (50 cases, 4 cases dropped out). The conventional palliative treatment was 
   performed in the control group. On the basis of conventional palliative 
   treatment, heat-sensitive moxibustion was added at Shenque (CV8) and Zhongwan 
   (CV12) in the observation group, once a day, 5 times a week, one course of 
   treatment was composed of 2 weeks, and 2 consecutive courses of treatment were 
   given. In the observation group, 15 patients voluntarily continued heat-sensitive 
   moxibustion treatment, which was collected in the sub-observation group No.1, 
   these patients were treated 3 times a week and for 6 months consecutively. Using 
   the propensity score matching method, 15 patients who only completed 2 courses of 
   treatment were assigned into the sub-observation group No.2. Before and after 
   treatment, the scores of European Organization for Research and Treatment of 
   Cancer quality of life questionnaire (EORTC QLQ-C30), the Karnofsky performance 
   status (KPS), and the anorexia/cachexia subscale-12 (A/CS-12), as well as the 
   immune indexes (the contents of serum immune globulin [Ig]G, IgA, IgM and 
   complements C3 and C4) were observed in the patients of the observation group and 
   the control group. The monthly survivals were recorded in the two sub-observation 
   groups after 6 months of treatment completion. The coordination was analyzed on 
   the score of deqi scale of heat-sensitive moxibustion at the probing stage before 
   treatment and the change in the score of EORTC QLQ-C30 before and after treatment 
   in the patients of the observation group. RESULTS: After treatment, except the 
   score related to the financial difficulties, the score of every items in EORTC 
   QLQ-C30 was greater than that before treatment in the observation group (P<0.05); 
   the scores for overall health, nausea/vomiting, pain, short breath, constipation 
   and diarrhea of the scale were higher than those before treatment in the control 
   group (P<0.05). The score for each item of the scale in the observation group was 
   higher when compared with that in the control group, except the score for 
   financial difficulties (P<0.05). After treatment, KPS score increased in the 
   observation group when compared with that before treatment (P<0.05), and the 
   score was higher than that of the control group (P<0.05). After treatment, 
   A/CS-12 score was elevated in comparison with that before treatment in each group 
   (P<0.05), and the score in the observation group was higher than that of the 
   control group (P<0.05). After treatment, in the observation group, the contents 
   of serum IgG, IgA and IgM, and C3 and C4 increased in comparison with those 
   before treatment (P<0.05); and in the control group, the contents of serum IgG, 
   C3 and C4 were declined (P<0.05). After treatment, the contents of serum IgG, IgA 
   and IgM, and C3 and C4 in the observation group were higher than those in the 
   control group (P<0.05). After 6 months of treatment completion, the survival rate 
   in the sub-observation group No.1 was higher than that of the sub-observation 
   group No.2 (P<0.05). In the observation group, the positive coordination was 
   presented between the score of deqi scale of heat-sensitive moxibustion and the 
   change in the score of EORTC QLQ-C30 in the observation group (r>0, P<0.001). 
   CONCLUSION: On the basis of palliative treatment, heat-sensitive moxibustion can 
   improve the quality of life, appetite and the immunity of the elderly patients 
   with malignant tumor. Consecutive long-term moxibustion is contributed to 
   prolonging the life span. The stronger deqi is felt during moxibustion delivery, 
   the more significant the therapeutic effect is obtained.
C1 Department of TCM, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
   First Department of Internal Medicine, Bo'xing County Hospital of TCM.
   Department of Moxibustion, Bo'xing County Hospital of TCM
   4College of Acupuncture-Moxibustion and Tuina, Jiangxi University of CM
   5AdministrationOffice of Heat-Sensitive Moxibustion, Affiliated Hospital of Jiangxi Universityof CM, Nanchang 330025.
   College of Acupuncture-Moxibustion and Tuina, Jiangxi University of CM.
   Administration Office of Heat-Sensitive Moxibustion, Affiliated Hospital of Jiangxi University of CM, Nanchang 330025.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD FEB 13
PY 2025
VL 45
IS 2
BP 167
EP 72
DI 10.13703/j.0255-2930.20240403-k0002 
PG -95
WC Humans; Moxibustion; Male; Female; Aged; Quality of Life; Neoplasms; therapy; Palliative Care; Aged, 80 and over; Middle Aged; Acupuncture Points
UT PubMed:39943757
PM 39943757
DA 2025-02-13
ER

PT J
AU Zou, J
   Dong, X
   Wang, K
   Shi, J
   Sun, N
AF Zou, Jing
   Dong, Xueyang
   Wang, Ke
   Shi, Jing
   Sun, Ning
TI Electroacupuncture Inhibits Autophagy of Neuron Cells in Postherpetic Neuralgia 
SO BioMed research international
LA English
DT Journal Article
AB Postherpetic neuralgia (PHN) is a complication of herpes zoster viral infection. 
   Its main manifestations are continuous or intermittent burning-like and 
   electroshock-like pain in the affected nerves. Electroacupuncture (EA) is widely 
   used in clinical treatment and exerts effects in alleviating neuropathic pain. In 
   this study, we investigated the effect and underlying mechanism of EA on PHN. 
   Sprague-Dawley rats were treated with resiniferatoxin (RTX) to establish a PHN 
   model and subjected to EA and/or miR-223-3p overexpression (OV) or interference. 
   Mechanical withdrawal latency was measured as an indication of pain sensitivity. 
   Hematoxylin-eosin staining and transmission electron microscopy were performed to 
   observe neuron cell morphology and autophagic vacuoles, respectively. ELISA was 
   performed to detect reactive oxygen species (ROS) production and the levels of 
   tumor necrosis factor- (TNF-) α, inducible nitric oxide synthase (iNOS), 
   interleukin- (IL-) 6, and IL-10. Changes in autophagy and apoptosis-related 
   miRNAs were detected by immunofluorescence and qRT-PCR, respectively. In 
   RTX-treated rats, OV and EA reduced pain sensitivity, decreased the number of 
   eosinophils, and increased that of nerve cells. ROS generation and the levels of 
   TNF-α and iNOS were significantly reduced, while those of IL-6 and IL-10 were 
   increased. OV and EA induced fewer autophagic vacuoles than those in the model 
   group. The expression of autophagy-related protein microtubule-associated protein 
   1 light chain 3-II, ATG9, and Rab1 was decreased by OV and EA, whereas that of 
   P62 was increased. qRT-PCR revealed that miR-223-3p expression in the model group 
   decreased but was increased by EA. EA inhibits neuron cell autophagy in PHN by 
   increasing miR-223-3p expression.
C1 Department of Neurobiology, School of Basic Medicine, Tongji Medical College of Huazhong University of Science and Technology, China.
   Department of Acupuncture & Moxibustion, Wuhan Hospital of Integrated Chinese & 
   Wuhan Hospital of Integrated Chinese & Western Medicine, China.
   Acupuncture College, Hubei University of Traditional Chinese Medicine, China.
   Department of Neurobiology, School of Basic Medicine, Tongji Medical College of Huazhong University of Science and Technology, China.
   Department of Neurobiology, School of Basic Medicine, Tongji Medical College of Huazhong University of Science and Technology, China.
NR 0
TC 0
SN 2314-614
EI 2314-613
J9 Biomed Res Int
PD APR 17
PY 2021
VL 2021
IS 
BP 6637693
EP 6637693
DI 10.1155/2021/6637693 
PG 0
WC Animals; Apoptosis; genetics; Autophagy; Diterpenes; Electroacupuncture; Gene Expression Regulation; Hyperalgesia; complications; Male; MicroRNAs; genetics; Neuralgia, Postherpetic; complications; Neuroglia; metabolism; Neurons; metabolism; Rats, Sprague-Dawley; rab1 GTP-Binding Proteins; metabolism; Rats
UT PubMed:33860046
PM 33860046
DA 2021-04-17
ER

PT J
AU Shao, JK
   Liu, Q
   Pei, W
   Wang, Y
   Yang, NN
   Qi, LY
   Huang, J
   Yang, JW
   Liu, CZ
AF Shao, Jia-Kai
   Liu, Qian
   Pei, Wei
   Wang, Yu
   Yang, Na-Na
   Qi, Ling-Yu
   Huang, Jin
   Yang, Jing-Wen
   Liu, Cun-Zhi
TI Electroacupuncture for postoperative ileus after laparoscopic surgery on 
SO Trials
LA English
DT Journal Article
DE Electroacupuncture; Postoperative ileus; Randomized controlled trial; Single acupoint
AB BACKGROUND: Postoperative ileus (POI) occurs in almost all patients after 
   abdominal laparoscopic surgery, resulting in complications and increasing the 
   length of hospitalization. Electroacupuncture has been used as an alternative 
   therapy for gastrointestinal dysfunction, but its efficacy for POI is 
   inconclusive. The study is designed to determine whether electroacupuncture can 
   accelerate recovery from POI. METHODS/DESIGN: This study is a three-arm, 
   randomized controlled trial. A total of 105 patients will be randomized into a 
   group receiving electroacupuncture at Tianshu (ST25), a group receiving 
   electroacupuncture at Zusanli (ST36), or a control group in a 1:1:1 ratio. 
   Patients in the electroacupuncture groups will receive electroacupuncture 
   treatment for 4 days from the first day after surgery. The primary outcome 
   consists of the time to first flatus and the time to first defecation. Secondary 
   outcomes include the time to first tolerance of liquid and semiliquid food; the 
   length of the hospital stay; postoperative pain, nausea, and vomiting; abdominal 
   distension; the time to first get out of bed; and postoperative complications. 
   The outcomes will be assessed by the patients themselves every day during 
   hospitalization. Surgeons, nurses, assessors, and statisticians will be blinded 
   to the group assignments. Patients in the two electroacupuncture groups, but not 
   in the control group, will be blinded to the group assignments. The 
   acupuncturists will not be blinded. DISCUSSION: The aim of this trial is to 
   provide a nonpharmacological therapy for POI and may provide evidence of the 
   effect of electroacupuncture at ST25 or ST36 on POI. TRIAL REGISTRATION: Chinese 
   Clinical Trial Registry ChiCTR1900027466 . Registered on 14 November 2019.
C1 International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, No.11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China.
   Department of Colorectal Surgery, Chinese Academy of Medical Sciences Cancer Institute and Hospital, Beijing, China.
   Department of Colorectal Surgery, Chinese Academy of Medical Sciences Cancer Institute and Hospital, Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, No.11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, No.11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, No.11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, No.11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, No.11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China.yangjw0626@126.com.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, No.11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China.
NR 0
TC 0
SN 1745-621
EI 
J9 Trials
PD SEP 11
PY 2021
VL 22
IS 1
BP 610
EP 610
DI 10.1186/s13063-021-05564-3 
PG 0
WC Colorectal Neoplasms; Electroacupuncture; adverse effects; Humans; Ileus; diagnosis; Laparoscopy; adverse effects; Postoperative Complications; etiology; Randomized Controlled Trials as Topic
UT PubMed:34503565
PM 34503565
DA 2021-09-11
ER

PT J
AU Lee, JH
   Gang, J
   Yang, E
   Kim, W
   Jin, YH
AF Lee, Ji Hwan
   Gang, Juan
   Yang, Eunhee
   Kim, Woojin
   Jin, Young-Ho
TI Bee Venom Acupuncture Attenuates Oxaliplatin-Induced Neuropathic Pain by 
SO Toxins
LA English
DT Journal Article
DE action potential; allodynia; bee venom acupuncture; oxaliplatin; voltage-gated sodium channel
AB Oxaliplatin is a third-generation platinum-based chemotherapeutic drug widely 
   used in colorectal cancer treatment. Although potent against this tumor, it can 
   induce cold and mechanical allodynia even after a single injection. The currently 
   used drugs to attenuate this allodynia can also cause unwanted effects, which 
   limit their use. Bee venom acupuncture (BVA) is widely used in Korean medicine to 
   treat pain. Although the effect of BVA on oxaliplatin-induced neuropathic pain 
   has been addressed in many studies, its action on dorsal root ganglia (DRG) 
   neurons has never been investigated. A single oxaliplatin injection (6 mg/kg, 
   intraperitoneally) induced cold and mechanical allodynia, and BVA (0.1 and 1 
   mg/kg, subcutaneous, ST36) dose-dependently decreased allodynia in rats. On 
   acutely dissociated lumbar 4-6 DRG neurons, 10 min application of oxaliplatin 
   (100 μM) shifted the voltage-dependence of sodium conductance toward negative 
   membrane potentials in A- but not C-fibers. The resting membrane potential 
   remained unchanged, but the action potential threshold decreased significantly 
   compared to that of the control (p < 0.05). However, 0.1 μg/mL of BVA 
   administration increased the lowered action potential threshold. In conclusion, 
   these results suggest that BVA may attenuate oxaliplatin-induced neuropathic pain 
   by altering the action potential threshold in A-fiber DRG neurons.
C1 Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Korea.
   Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 
   Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul 02453, Korea.
   Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02453, Korea.
   Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Korea.
   Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 
   Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul 02453, Korea.
   Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02453, Korea.
NR 0
TC 0
SN 2072-665
EI 
J9 Toxins (Basel)
PD DEC 2
PY 2020
VL 12
IS 12
BP 
EP 
DI 10.3390/toxins12120737 
PG 0
WC Action Potentials; drug effects; Acupuncture Therapy; Animals; Antineoplastic Agents; therapeutic use; Bee Venoms; pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; drug effects; Hyperalgesia; chemically induced; Neuralgia; chemically induced; Neurons; drug effects; Oxaliplatin; adverse effects; Rats; Rats, Sprague-Dawley; Voltage-Gated Sodium Channels; metabolism
UT PubMed:33255279
PM 33255279
DA 2020-12-02
ER

PT J
AU Gianni, C
   Scarpi, E
   Bravaccini, S
   Pirini, F
   Vanni, S
   Dall'Agata, M
   Cortesi, M
   Fanini, F
   Cavalieri, S
   Mercatali, L
   Ulivi, P
   Poini, A
   Giovanardi, CM
   Rocca, A
   Fedeli, A
AF Gianni, Caterina
   Scarpi, Emanuela
   Bravaccini, Sara
   Pirini, Francesca
   Vanni, Silvia
   Dall'Agata, Monia
   Cortesi, Michela
   Fanini, Francesca
   Cavalieri, Sara
   Mercatali, Laura
   Ulivi, Paola
   Poini, Alessandra
   Giovanardi, Carlo Maria
   Rocca, Andrea
   Fedeli, Anna
TI Investigating biochemical markers of Acupuncture's effectiveness in managing 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture; Breast cancer; Cytokines; Hot flushes; Menopause; TNF-α
AB BACKGROUND: Breast cancer (BC) remains a global health issue, with most women 
   receiving adjuvant hormone therapy. Hot flushes and climacteric symptoms often 
   compromise treatment adherence. Acupuncture has shown promise in alleviating 
   these symptoms and improving quality of life (QoL). This prospective study aimed 
   to investigate the mechanisms underlying acupuncture's effects on menopausal 
   symptoms in breast cancer patients receiving endocrine therapy, with a secondary 
   focus on inflammatory biomarker changes. METHODS: This open-label biological 
   study enrolled 37 early BC patients receiving endocrine treatment, and 
   acupuncture treatment provided at IRST within the integrative care pathway, of 
   whom 27 completed all evaluations. Participants underwent a 10-session weekly 
   acupuncture program based on Traditional Chinese Medicine, using fixed points 
   (SP6, CV4, LI11, BL11, GB39). Blood samples for biochemical and cytokine analysis 
   (IL-5, IL-6, IL-10, IL-8, IL-22, TNFα) were collected at baseline (T0), 
   post-treatment (T1), and six months later (T2) during regular clinical and 
   laboratory workups. Clinical outcomes were assessed using the Green Climacteric 
   Scale (GCS), EQ-5D-5L, and Brief Pain Inventory (BPI). The study followed STRICTA 
   guidelines. RESULTS: Acupuncture significantly improved vasomotor and climacteric 
   symptoms, with reduced GCS and hot flash scores at T1 and T2 (p < 0.0001). QoL 
   and pain scores also significantly improved at both time points. Among the 
   cytokines measured over time, a significant reduction in TNFα levels was observed 
   (p = 0.006), though no correlation emerged between cytokine changes and clinical 
   outcomes. CONCLUSIONS: Acupuncture proved effective in improving menopausal 
   symptoms and QoL in BC patients receiving endocrine therapy. The modulation of 
   TNFα suggests a potential biological role in the mechanism of symptom relief.
C1 Medical Oncology and Breast Unit, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST), Dino Amadori", Via P. Maroncelli 40, 47014, Meldola, FC, Italy.
   Unit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) "Dino Amadori", Via P. Maroncelli 40, 47014, Meldola, FC,Italy. emanuela.scarpi@irst.emr.it.
   Department of Medicine and Surgery, University of Enna "Kore", 94100, Enna, Italy.
   Biosciences Laboratory, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) "Dino Amadori", Via P. Maroncelli 40, 47014, Meldola, FC, Italy.
   Preclinic and Osteoncology Unit, Biosciences Laboratory, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) "Dino Amadori", Via P. Maroncelli 40, 47014,Meldola, FC, Italy.
   Unit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) "Dino Amadori", Via P. Maroncelli 40, 47014, Meldola, FC,Italy.
   Biosciences Laboratory, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) "Dino Amadori", Via P. Maroncelli 40, 47014, Meldola, FC, Italy.
   Immuno-Gene Therapy Factory, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori IRST "Dino Amadori", Via P. Maroncelli 40, 47014, Meldola, FC, Italy.
   Medical Oncology, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori IRST "Dino Amadori", Via P. Maroncelli 40, 47014, Meldola, FC, Italy.
   Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies, IRCCS Istituto Ortopedico Rizzoli, Via Di Barbiano 1/10, 40136, Bologna, Italy.
   Biosciences Laboratory, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) "Dino Amadori", Via P. Maroncelli 40, 47014, Meldola, FC, Italy.
   Research and Healthcare Institute of Association of Medical Acupuncturists of Bologna (A.M.A.B.), Via Antonio Canova, 15/E, 40138, Bologna, Italy.
   Research and Healthcare Institute of Association of Medical Acupuncturists of Bologna (A.M.A.B.), Via Antonio Canova, 15/E, 40138, Bologna, Italy.
   Department of Medical, Surgical and Health Sciences, University of Trieste, Piazza Università 1, 34127, Trieste, Italy.
   Research and Healthcare Institute of Association of Medical Acupuncturists of Bologna (A.M.A.B.), Via Antonio Canova, 15/E, 40138, Bologna, Italy.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD NOV 20
PY 2025
VL 33
IS 12
BP 1099
EP 1099
DI 10.1007/s00520-025-10181-w 
PG 0
WC Humans; Female; Breast Neoplasms; therapy; Middle Aged; Acupuncture Therapy; methods; Prospective Studies; Hot Flashes; therapy; Quality of Life; Cytokines; blood; Biomarkers; blood; Aged; Menopause; Adult; Treatment Outcome
UT PubMed:41264030
PM 41264030
DA 2025-11-20
ER

PT J
AU Jin, X
   Zhang, Y
   Chang, B
   Ren, J
   Hao, J
   Cao, Y
   Wang, H
   Ji, L
AF Jin, Xu
   Zhang, Yanlin
   Chang, Boya
   Ren, Jia
   Hao, Jianheng
   Cao, Yuxia
   Wang, Haijun
   Ji, Laixi
TI [Analgesic effect of "Zhibian" (BL54)-toward-"Shuidao" (ST28) needling technique 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE NOD1/RIP2/NF-κB signaling pathway; Zhibian (BL54)-toward-Shuidao (ST28); acupuncture; inflammatory response; pain; primary dysmenorrhea
AB OBJECTIVE: To observe the effect of "Zhibian" (BL54)-toward-"Shuidao" (ST28) 
   needling technique on the relative protein expression of the signaling pathway of 
   nucleotide-binding oligomerization domain-containing protein 1 (NOD1)/ 
   receptor-interacting protein 2 (RIP2)/nuclear factor kappa-B (NF-κB) and the 
   expression of proinflammatory cytokines in the rats with primary dysmenorrhea 
   (PD), so as to explore the underlying mechanism of this acupuncture technique for 
   pain alleviation in PD. METHODS: Thirty female SD rats of SPF grade with normal 
   estrous cycle were randomized into a blank group, a model group and an 
   acupuncture group, 10 rats in each one. Using the intraperitoneal injection with 
   estradiol benzoate combined with oxytocin, PD model was prepared in the model 
   group and the acupuncture group. In the acupuncture group, during model 
   preparation, the intervention with "Zhibian" (BL54)-toward-"Shuidao" (ST28) 
   needling technique was delivered simultaneously, 20 min each time, once daily for 
   consecutive 10 days. On day 11, within 30 min after the intraperitoneal injection 
   with oxytocin, the writhing reaction (latency, frequency and score) was recorded; 
   the morphology of uterine tissue was observed with HE staining, the contents of 
   prostaglandin E(2) (PGE(2)), prostaglandin F(2α) (PGF(2α)), interleukin (IL)-1β, 
   IL-18, cyclooxygenase-2 (COX-2), and tumor necrosis factor-α(TNF-α) in the serum 
   were detected using ELISA method; the relative protein expression of NOD1, RIP2, 
   NF-κB p65, phosphorylation-NF-κB p65 (p-NF-κB p65) was detected in the uterine 
   tissue using Western blot method; and the mRNA expression of NOD1, RIP2 and NF-κB 
   p65 was detected with the quantitative real-time PCR employed. RESULTS: Compared 
   with the blank group, in the model group, the writhing latency was prolonged 
   (P<0.01), the writhing frequency and score increased (P<0.01) in the rats; the 
   endometrial epithelial cells showed massive degeneration and necrosis, with 
   severe endometrial edema and widespread shedding, combined with neutrophil 
   infiltration; the serum PGE(2) content was dropped (P<0.01), while those of 
   PGF(2α), IL-1β, IL-18, COX-2, and TNF-α elevated (P<0.01); the protein expression 
   of NOD1, RIP2, NF-κB p65 and p-NF-κB p65, and the mRNA expression of NOD1, RIP2 
   and NF-κB p65 in uterine tissue increased (P<0.01). In comparison with the model 
   group, in the acupuncture group, the writhing latency was prolonged (P<0.01), the 
   writhing frequency and score were reduced (P<0.01) in the rats; there was less 
   degeneration and necrosis of endometrial epithelial cells, with mild endometrial 
   edema and very little neutrophil infiltration; the serum PGE(2) content increased 
   (P<0.01), while those of PGF(2α), IL-1β, IL-18, COX-2, and TNF-α decreased 
   (P<0.01); the protein expression of NOD1, RIP2, NF-κB p65 and p-NF-κB p65 and the 
   mRNA expression of NOD1, RIP2 and NF-κB p65 in uterine tissue were dropped 
   (P<0.05, P<0.01). CONCLUSION: "Zhibian" (BL54)-toward-"Shuidao" (ST28) needling 
   technique can alleviate the pain symptom of PD rats, and its action mechanism may 
   be related to inhibiting the active expression of NOD1/RIP2/NF-κB signaling 
   pathway in the uterine tissue, thereby reducing the inflammatory response.
C1 Second Clinical College, Shanxi University of CM, Jinzhong 030619, China.
   School of Acupuncture-Moxibustion and Tuina, Tianjin University of TCM.
   Second Clinical College, Shanxi University of CM, Jinzhong 030619, China.
   Second Clinical College, Shanxi University of CM, Jinzhong 030619, China.
   Second Clinical College, Shanxi University of CM, Jinzhong 030619, China.
   Affiliated Hospital of Acupuncture-Moxibustion and Tuina, Shanxi University of CM, Taiyuan 030012.
   Affiliated Hospital of Acupuncture-Moxibustion and Tuina, Shanxi University of CM, Taiyuan 030012.
   Affiliated Hospital of Acupuncture-Moxibustion and Tuina, Shanxi University of CM, Taiyuan 030012.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD FEB 13
PY 2025
VL 45
IS 2
BP 209
EP 16
DI 10.13703/j.0255-2930.20240331-k0001 
PG -193
WC Animals; Female; Rats, Sprague-Dawley; Rats; Signal Transduction; Dysmenorrhea; therapy; NF-kappa B; genetics; Acupuncture Points; Humans; Acupuncture Analgesia; Nod1 Signaling Adaptor Protein; genetics; Receptor-Interacting Protein Serine-Threonine Kinase 2; genetics; Acupuncture Therapy
UT PubMed:39943763
PM 39943763
DA 2025-02-13
ER

PT J
AU Aderibigbe, O
   Groft-MacFarlane, C
   Chu, EY
AF Aderibigbe, Oyinade
   Groft-MacFarlane, Caroline
   Chu, Emily Y
TI A Blue-Gray Macule on the Back: Challenge.
SO The American Journal of dermatopathology
LA English
DT Journal Article
C1 Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA
   and.
   Dermatology Associates of Bryn Mawr Medical Specialists, Bryn Mawr, PA.
   Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA
   and.
NR 0
TC 0
SN 1533-031
EI 
J9 Am J Dermatopathol
PD OCT 12
PY 2018
VL 42
IS 1
BP e4
EP e4
DI 10.1097/DAD.0000000000001268 
PG 1
WC Acupuncture Therapy; methods; Biopsy, Needle; Chronic Pain; therapy; Diagnosis, Differential; Follow-Up Studies; Humans; Immunohistochemistry; Low Back Pain; diagnosis; Male; Middle Aged; Nevus, Blue; diagnosis; Ochronosis; diagnosis; Pigmentation Disorders; diagnosis; Rare Diseases
UT PubMed:30308544
PM 30308544
DA 2018-10-12
ER

PT J
AU Qiu, ML
   Sun, KL
   Zhong, JW
   Sun, LQ
   Zhou, LQ
   Wu, Q
   Song, ZY
   Pan, YY
   Lou, Y
   Yuan, X
   Li, J
AF Qiu, Man-Li
   Sun, Kai-Long
   Zhong, Jun-Wu
   Sun, Li-Qin
   Zhou, Ling-Qin
   Wu, Qi
   Song, Zhe-Yu
   Pan, Yuan-Yuan
   Lou, Ying
   Yuan, Xu
   Li, Jing
TI [Short needling for knee osteoarthritis with blood stasis obstruction and its 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture; knee osteoarthritis; randomized controlled trial (RCT); short needling
AB OBJECTIVE: To compare the clinical efficacy and its effect on serum levels of 
   tumor necrosis factor α(TNF-α), interleukin 1β(IL-1β), interleukin 6 (IL-6) and 
   prostaglandin E(2) (PGE(2)) between short needling (close-to-bone needling) and 
   conventional acupuncture for knee osteoarthritis (KOA) with blood stasis 
   obstruction. METHODS: A total of 68 KOA patients with blood stasis obstruction 
   were randomized into a short needling group (34 cases, 3 cases dropped off) and a 
   conventional acupuncture group (34 cases, 3 cases dropped off). The same 
   acupoints (Dubi [ST 35], Neixiyan [EX-LE 4], Binzhong [Extra], Liangqiu [ST 34], 
   etc. on the affected side) were selected in the two groups. In the short needling 
   group, short needling technique was adopted, the needles were slowly inserted and 
   the needle bodies were shaken, thus gradually penetrated to the bone. In the 
   conventional acupuncture group, conventional acupuncture was adopted, the needles 
   were penetrated to the muscle. After qi-arrival, Dubi (ST 35) and Neixiyan (EX-LE 
   4), Zusanli (ST 36) and Liangqiu (ST 34) were connected with CMNS6-1 electronic 
   acupuncture instrument, with disperse-dense wave, 2 Hz/10 Hz in frequency, the 
   current intensity was based on patients' feeling, the needles were retained for 
   30 min, at the same time, the knee joint was irradiated for 30 min with a special 
   electromagnetic wave apparatus in the two groups. Once every other day, 3 times a 
   week for 4 weeks. Before and after treatment, the Western Ontario and McMaster 
   Universities osteoarthritis index (WOMAC) score, knee joint pain visual analogue 
   scale (VAS) score, inflammatory response related indexes (serum TNF-a, IL-1β, 
   IL-6 and PGE(2)) and knee joint ultrasound were observed，and the clinical effect 
   was evaluated in the two groups. RESULTS: After treatment，the pain, stiffness, 
   function scores and total scores of WOMAC were decreased as compared with those 
   before treatment in the two groups (P<0.05), except for the pain score, the 
   changes of above scores in the short needling group were greater than the 
   conventional acupuncture group (P<0.05). After treatment, the VAS scores, serum 
   levels of TNF-a, IL-1β, IL-6, PGE(2) and knee joint synovium thickness, 
   intra-articular effusion were decreased as compared with those before treatment 
   in the two groups (P<0.05), the levels of TNF-a, IL-1β, IL-6 in the short 
   needling group were lower than the conventional acupuncture group (P<0.05). The 
   total effective rate in the short needling group was 87.1% (27/31), which was 
   superior to 83.9% (26/31) in the conventional acupuncture group (P<0.05). 
   CONCLUSION: Short needling could improve the knee joint function, relieve the 
   pain and inflammatory response, improve the knee joint synovium inflammatory 
   response, reduce the knee joint intra-articular effusion for KOA patients, its 
   effect is better than conventional acupuncture.
C1 Department of Acupuncture and Moxibustion, Shanghai Putuo Hospital of TCM, Shanghai 200062, China.
   Department of Acupuncture and Moxibustion, Shanghai Putuo Hospital of TCM, Shanghai 200062, China.
   Department of Acupuncture and Moxibustion, Shanghai Putuo Hospital of TCM, Shanghai 200062, China.
   Department of Acupuncture and Moxibustion, Shanghai Putuo Hospital of TCM, Shanghai 200062, China.
   Department of Acupuncture and Moxibustion, Shanghai Putuo Hospital of TCM, Shanghai 200062, China.
   Department of Acupuncture and Moxibustion, Shanghai Putuo Hospital of TCM, Shanghai 200062, China.
   Department of Acupuncture and Moxibustion, Shanghai Putuo Hospital of TCM, Shanghai 200062, China.
   Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai200437.
   Department of Acupuncture and Moxibustion, Shanghai Putuo Hospital of TCM, Shanghai 200062, China.
   Department of TCM, Shanghai Putuo Central Hospital.
   Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai200437.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUL 7
PY 2022
VL 42
IS 7
BP 733
EP 8
DI 10.13703/j.0255-2930.20210901-k0008 
PG -725
WC Acupuncture Points; Humans; Inflammation; Interleukin-6; Osteoarthritis, Knee; therapy; Pain; Prostaglandins E
UT PubMed:35793881
PM 35793881
DA 2022-07-07
ER

PT J
AU Huang, W
   Long, W
   Xiao, J
   Zhao, G
   Yu, T
AF Huang, Wei
   Long, Wenfei
   Xiao, Jianbin
   Zhao, Gaofeng
   Yu, Tingyu
TI Effect of electrically stimulating acupoint, Zusanli (ST 36), on patient's 
SO Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
LA English
DT Journal Article
DE Colorectal neoplasms; Laparoscopes; Randomized controlled trial; Recovery of function; Transcutaneous electric nerve stimulation
AB OBJECTIVE: To investigate the effect of transcutaneous electrical acupoint 
   stimulation (TEAS) on enhanced recovery after surgery (ERAS) in laparoscopic 
   colorectal cancer resection and its clinical significance. METHODS: Sixty-four 
   patients undergoing laparoscopic colorectal resection were randomly divided into 
   two groups, the control group (group A) and the TEAS group (group B). Patients in 
   the TEAS group received electroacupuncture stimulation of bilateral Zusanli (ST 
   36) at 30 min before anesthesia to the end of surgery. The patients in the 
   control group were not given the stimulation. Perioperative anesthesia management 
   of the two groups were performed according to the ERAS guidelines, and 
   postoperative patient-controlled intravenous analgesia (PCIA) was used. The 
   amount of remifentanil used in the two groups was observed and recorded, and the 
   visual analogue scale (VAS) of the 4, 12, 24 and 48 h after surgery in the two 
   groups was recorded. Moreover, postoperative anal exhaust time, postoperative 
   feeding time, postoperative first ambulation time and postoperative hospital stay 
   length were compared between the two groups. RESULTS: Compared with group A, the 
   VAS score of group B decreased significantly at 48 h after operation (P < 0.05). 
   The postoperative anal exhaust time in group B was significantly shorter than 
   that of group A (P < 0.05). There was no significant difference between the two 
   groups with regards to remifentanil consumption, postoperative feeding time, 
   postoperative first ambulation time and postoperative hospital stay (all P > 
   0.05). CONCLUSION: TEAS can promote the recovery of postoperative 
   gastrointestinal function and reduce the pain intensity 48 h after surgery, thus 
   satisfying the need of early postoperative analgesia.
C1 Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China.
   Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China.
   Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China.
   Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China.
   Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China.
NR 0
TC 0
SN 2589-451
EI 
J9 J Tradit Chin Med
PD MAR 19
PY 2020
VL 39
IS 3
BP 433
EP 439
DI 
PG 6
WC Acupuncture Points; Aged; Colorectal Neoplasms; surgery; Humans; Laparoscopy; Middle Aged; Recovery of Function; physiology; Transcutaneous Electric Nerve Stimulation
UT PubMed:32186016
PM 32186016
DA 2020-03-19
ER

PT J
AU Wang, WJ
   Lu, J
   Niu, CS
   Huang, YR
   Ma, Q
   A, YG
   Hao, HW
   Li, LM
   Tu, Y
AF Wang, Wei-jun
   Lu, Jun
   Niu, Chuan-sen
   Huang, Yi-ran
   Ma, Qing
   A, Ying-ge
   Hao, Hong-wei
   Li, Lu-ming
   Tu, Ya
TI [Effects of electroacupuncture of unilateral and bilateral "zusanli" (ST 36) on 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
AB OBJECTIVE: To observe the effect of electroacupuncture (EA) on serum tumor 
   necrosis factor-alpha (TNF-alpha), IL-1 and IL-4 levels in rats with chronic 
   inflammatory pain, so as to investigate its underlying mechanism in relieving 
   pain. Methods Forty-eight SD rats were randomized into control, model, 
   EA-unilateral ST 36, and EA-bilateral ST 36 groups, with 12 rats in each. Chronic 
   inflammatory pain model was established by intradermal injection of Freund's 
   complete adjuvant (0.1 mL) into the right paw. EA (2 Hz/100 Hz, 1-2-3 mA) was 
   applied to the unilateral "Zusanli" (ST 36) and bilateral "Zusanli" (ST 36) for 
   30 min, once every 3 days and continuously for 4 weeks. Serum TNF-alpha, IL-1 and 
   IL-4 contents were detected by enzyme linked immunosorbent assay. Results 
   Compared with the control group, serum TNF-alpha, IL-1 and IL-4 contents of the 
   model group increased significantly (P < 0.01), while in comparison with the 
   model group, the levels of the 3 indexes were decreased considerably in both 
   unilateral and bilateral ST 36 groups (P < 0.01). No significant differences were 
   found between the unilateral ST 36 and bilateral ST 36 groups in serum TNF-alpha, 
   IL-1 and IL-4 contents (P > 0.05). CONCLUSION: EA can effectively lower serum 
   TNF-alpha, IL-1 and IL-4 levels in inflammatory pain rats, which may contribute 
   to its effect in relieving inflammatory pain.
C1 School of Acu-moxibustion and Massage, Beijing University of Chinese Medicine, Beijing 100029, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD MAR 8
PY 2011
VL 35
IS 6
BP 429
EP 32
DI 
PG -397
WC Acupuncture Points; Animals; Chronic Disease; therapy; Disease Models, Animal; Electroacupuncture; Humans; Interleukin-1; blood; Interleukin-4; blood; Male; Pain; blood; Pain Management; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; blood
UT PubMed:21375016
PM 21375016
DA 2011-03-08
ER

PT J
AU Shi, RY
   Fu, TF
   Cai, YQ
   Du, JY
   Fang, JF
   Fang, JQ
   Liang, Y
AF Shi, Ren-Yi
   Fu, Tao-Fang
   Cai, Yang-Qian
   Du, Jun-Ying
   Fang, Jun-Fan
   Fang, Jian-Qiao
   Liang, Yi
TI [Electroacupuncture intervention relieves pain possibly by promoting MOR 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Bone cancer pain; Electroacupuncture; Endocytosis of receptor; Locus coeruleus (LC); Morphine tolerance; µ-opioid receptor
AB OBJECTIVE: To observe the effect of electroacupuncture (EA) on pain behavior and 
   expression of µ-opioid receptor (MOR) and Rab5 (an important protein molecule for 
   internalization of MOR) in the locus coeruleus (LC) region in bone cancer pain 
   (BCP) rats with morphine tolerance (MT), so as to explore its mechanisms 
   underlying improvement of BCP and MT. METHODS: The present study included two 
   parts. In the first part, 23 female SD rats were randomized into sham BCP (n＝6), 
   BCP (n＝9) and BCP＋MT (n＝8) groups, and in the second part, 61 female SD rats were 
   randomized into 5 groups: sham BCP (n＝11), BCP (n＝11), BCP＋MT (n＝13), BCP＋MT＋EA 
   (n＝13) and BCP＋MT＋sham EA (n＝13). The BCP morphine tolerance (BCP＋MT) model was 
   established by injection of 10 µL of human Walker 256 breast cancer cells (MRMT-1 
   breast cancer cells, 1 x10(4) cells/µL) into the bone marrow cavity at the upper 
   part of the left tibia and intraperitoneal injection of morphine hydrochloride 
   (10 mg/kg, once per 12 h, for 11 successive days). On day 21 after inoculation, 
   EA (2 Hz/100 Hz, 0.5－1.5 mA, increasing 0.5 mA every 10 min) was began to applied 
   to bilateral "Zusanli" (ST30) and "Kunlun" (BL60) immediately after the first 
   intraperitoneal injection of morphine. The treatment was performed for 30 min 
   every time, once daily for 7 successive days. The paw withdrawal threshold (PWT) 
   was detected before and 10, 11, 21, 22, 24, 26 and 28 days after inoculation. The 
   immunoactivity of MOR and Rab5 proteins in the LC region was detected by 
   immunofluorescence histochemistry. RESULTS: In the first part of the study, at 
   the 10(th) day after inoculation of cancer cells, the PWT of the BCP and BCP＋MT 
   groups was significantly lower than that of the sham BCP group (P<0.05), 
   suggesting a success of BCP model. From day 11 to 19 after inoculation (during 
   injection of morphine), the PWTs of the BCP＋MT group were significantly higher 
   than those of the BCP group (P<0.01), and on day 21, the PWT of the BCP＋MT group 
   was similar to that of the BCP group (P>0.05) but significantly lower than that 
   of the sham BCP group (P<0.01), suggesting a success of MT. H．E. staining showed 
   a large quantity of MRMT-1 cancer cells in the bone marrow cavity in both BCP and 
   BCP＋MT groups. In the second part of the study, the decreased PWTs from 10(th) to 
   28(th) day after inoculation were significantly increased on day 22, 24, 26 and 
   28 in the BCP＋MT＋EA group relevant to the BCP, BCP＋MT and BCP＋MT＋sham EA groups 
   (P<0.01). The ratios of MOR and Rab5 positive ((＋)) cells and MOR(＋)/Rab5(＋) of 
   the left LC region were significantly lower in the BCP and BCP＋MT groups than 
   those of the sham BCP group (P<0.01), but were considerably higher in the 
   BCP＋MT＋EA group than those in the BCP, BCP＋MT and BCP＋MT＋sham EA groups (P<0.01). 
   The ratios of Rab5(＋) and MOR(＋)/Rab5(＋) cells of the BCP＋MT group were 
   significantly lower than those of the BCP group (P<0.05). No significant changes 
   were found in the ratios of MOR(＋) and Rab5(＋) cells and MOR(＋)/Rab5(＋) cells 
   after BCP＋MT＋sham EA in comparison with the BCP＋MT group (P>0.05). CONCLUSION: EA 
   intervention can relieve pain and MT in bone cancer pain rats with MT, which may 
   be related to its effects in increasing MOR expression and promoting endocytosis 
   of MOR in LC region.
C1 Laboratory of Neuro-biology and Acupuncture Research, the Third Clinical Medical College, Zhejiang University of Chinese Medicine, Hangzhou 310053, China.
   Laboratory of Neuro-biology and Acupuncture Research, the Third Clinical Medical College, Zhejiang University of Chinese Medicine, Hangzhou 310053, China.
   Laboratory of Neuro-biology and Acupuncture Research, the Third Clinical Medical College, Zhejiang University of Chinese Medicine, Hangzhou 310053, China.
   Laboratory of Neuro-biology and Acupuncture Research, the Third Clinical Medical College, Zhejiang University of Chinese Medicine, Hangzhou 310053, China.
   Laboratory of Neuro-biology and Acupuncture Research, the Third Clinical Medical College, Zhejiang University of Chinese Medicine, Hangzhou 310053, China.
   Laboratory of Neuro-biology and Acupuncture Research, the Third Clinical Medical College, Zhejiang University of Chinese Medicine, Hangzhou 310053, China.
   Laboratory of Neuro-biology and Acupuncture Research, the Third Clinical Medical College, Zhejiang University of Chinese Medicine, Hangzhou 310053, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD APR 5
PY 2019
VL 44
IS 3
BP 161
EP 9
DI 10.13702/j.1000-0607.180635 
PG -152
WC Animals; Cancer Pain; Cell Line, Tumor; Electroacupuncture; Endocytosis; Female; Humans; Locus Coeruleus; Morphine; Rats; Rats, Sprague-Dawley
UT PubMed:30945497
PM 30945497
DA 2019-04-05
ER

PT J
AU Huemer, M
   Graca, S
   Bitsche, S
   Hofmann, G
   Armour, M
   Pichler, M
AF Huemer, Matthias
   Graca, Sandro
   Bitsche, Sarah
   Hofmann, Guenter
   Armour, Mike
   Pichler, Martin
TI Mapping the clinical practice of traditional, complementary and integrative 
SO Journal of integrative medicine
LA English
DT Journal Article
DE Acupuncture; Evidence-informed practice; Integrative medicine; International survey; Oncology
AB BACKGROUND: Many cancer patients seek adjunctive therapies to biomedical cancer 
   treatments at some point of their disease trajectory. While acupuncture is 
   increasingly recommended by leading oncological associations, limited evidence 
   exists concerning the evidence-informed practice and adherence to current 
   guidelines of traditional complementary and integrative medicine (TCIM) 
   practitioners treating cancer patients. METHODS: An international online-survey 
   assessed the demographical data, clinical practice, and sources of information 
   used by TCIM practitioners in Austria, Germany, United States of America, 
   Australia, and New Zealand. RESULTS: In total, 404 respondents completed the 
   survey, of which 254 (62.9%) treated cancer patients. Most practitioners were 
   acupuncturists and herbalists (57.1%), had (16.8 ± 9.9) years of clinical 
   experience and see a median of 2 (1, 4) cancer patients per week. Breast cancer 
   (61.8%) is the most common cancer type seen in TCIM clinics. Adjunctive TCIM 
   treatments are frequently concurrent with the patient's cancer specific treatment 
   (39.9%), which is also reflected by the main goal of a TCIM treatment to 
   alleviate side effects (52.4%). However, only 28.0% of the respondents are in 
   contact with the treating oncologist. According to the respondents, pain is most 
   effectively treated using acupuncture, while herbal medicine is best for 
   cancer-related fatigue. TCIM practitioners mostly use certified courses (33.1%) 
   or online databases (28.3%) but often believe that experts are more reliable to 
   inform their practice (37.0%) than research publications (32.7%). CONCLUSION: 
   Acupuncturists and herbalists commonly treat cancer patients. Most practitioners 
   use TCIM as an adjunct to biomedicine as supportive care and use it largely in 
   accordance with current oncological guidelines. PLEASE CITE THIS ARTICLE AS: 
   Huemer M, Graca S, Bitsche S, Hofmann G, Armour M, Pichler M. Mapping the 
   clinical practice of traditional, complementary and integrative medicine in 
   oncology in Western countries: A multinational cross-sectional survey. J Integr 
   Med. 2024; 22(1): 64-71.
C1 Palliative Care Unit, Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria. 
   Northern College of Acupuncture, York YO1 6LJ, United Kingdom
   School of Health and Society, Faculty of Education, Health and Wellbeing, University ofWolverhampton, Wolverhampton WV1 1LY, United Kingdom.
   Palliative Care Unit, Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
   Palliative Care Unit, Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
   National Institute of Complementary Medicine Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia
   Translational Health ResearchInstitute, Western Sydney University, Penrith, NSW 2751, Australia
   MedicalResearch Institute of New Zealand, Wellington 6021, New Zealand.
   Palliative Care Unit, Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
   Translational Oncology,University Hospital of Augsburg, 86156 Augsburg, Germany.
EM atthias.huemer@medunigraz.at
NR 0
TC 0
SN 
EI 2095-496
J9 J Integr Med
PD JAN 11
PY 2024
VL 22
IS 1
BP 64
EP 71
DI 10.1016/j.joim.2023.12.002 
PG 7
WC Humans; Female; Complementary Therapies; Cross-Sectional Studies; Integrative Medicine; Acupuncture Therapy; Breast Neoplasms
UT PubMed:38199884
PM 38199884
DA 2024-01-11
ER

PT J
AU Yuan, SY
   Qin, Z
   Liu, DS
   Yin, WQ
   Zhang, ZL
   Li, SG
AF Yuan, Shao-Ying
   Qin, Zhan
   Liu, Dong-Sheng
   Yin, Wei-Qiang
   Zhang, Zhao-Lei
   Li, Shen-Guo
TI [Acupuncture for chronic pelvic pain syndromes (CPPS) and its effect on cytokines 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB OBJECTIVE: To explore the effect of acupuncture on chronic pelvic pain syndromes 
   (CPPS), and its therapeutic mechanism. METHODS: Fourty-seven cases of CPPS were 
   treated with electroacupuncture on Zhongji (CV 3), Guilai (ST 29), Yinlingquan 
   (SP 9), Sanyinjiao (SP 6), Guanyuan (CV 4), Shuidao(ST 28), Xuehai (SP 10) and 
   Taichong (LR 3) as main acupoints. Chronic Prostatitis Symptom Index (CPSI) was 
   adopted to grade the severity of pain or discomforts. Additionally, the levels of 
   Interleukin-8 (IL-8), Interleukin-10 (IL-10) and Tumor necrosis factor-alpha 
   (TNF-alpha) in prostate fluid were detected and the correlation between those 
   changes and pain score was analyzed. RESULTS: After treatment, pain or discomfort 
   score in CPSI decreased remarkably as compared with that before treatment (P < 
   0.01). The levels of IL-8, IL-10 and TNF-alpha were lower than those before 
   treatment (P < 0.01, P < 0.05). The positive correlation was obtained between 
   IL-10 level and pain score (P < 0.05). The total effective rate was 89.4% 
   (42/47). CONCLUSION: Acupuncture has significant efficacy on CPPS through 
   reducing IL-10 level to ease pain, and reducing the levels of IL-8 and TNF-alpha 
   to relieve inflammatory reaction.
C1 Male Department of Zhuhai Branch of Guangdong Provincial TCM Hospital, Zhuhai 519000, China. ysy017@126.com
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAR 2
PY 2011
VL 31
IS 1
BP 11
EP 4
DI 
PG -7
WC Acupuncture Points; Acupuncture Therapy; Adult; Body Fluids; immunology; Chronic Disease; therapy; Humans; Interleukin-10; immunology; Interleukin-8; immunology; Male; Middle Aged; Pelvic Pain; immunology; Prostate; immunology; Tumor Necrosis Factor-alpha; immunology; Young Adult
UT PubMed:21355145
PM 21355145
DA 2011-03-02
ER

PT J
AU Zhang, K
   Tang, Q
AF Zhang, Kai
   Tang, Qilin
TI Acupuncture on aromatase inhibitor-induced arthralgia in patients with breast 
SO Breast (Edinburgh, Scotland)
LA English
DT Letter
C1 Department of Acupuncture and Moxibustion, Tianjin Gong An Hospital, Tianjin, China. 
   Tianjin University of Traditional Chinese Medicine, Tianjin, China.
EM coolzhangkai@163.com
NR 0
TC 0
SN 1532-308
EI 
J9 Breast
PD APR 29
PY 2019
VL 45
IS 
BP 119
EP 119
DI 10.1016/j.breast.2019.01.010 
PG 0
WC Acupuncture Therapy; Aromatase; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Humans; Randomized Controlled Trials as Topic
UT PubMed:31029376
PM 31029376
DA 2019-04-29
ER

PT J
AU Wang, ZY
   Liu, CZ
   Pei, W
   Zhang, TZ
   Zhang, J
   Fan, WW
   Wei, XY
   Tu, JF
   Wang, L
   Wang, X
   Yang, NN
AF Wang, Ze-Yi
   Liu, Cun-Zhi
   Pei, Wei
   Zhang, Tian-Zhen
   Zhang, Jing
   Fan, Wen-Wen
   Wei, Xiao-Ya
   Tu, Jian-Feng
   Wang, Lu
   Wang, Xu
   Yang, Na-Na
TI Investigating the efficacy of electroacupuncture for postoperative ileus in 
SO BMJ open
LA English
DT Journal Article
DE Acupuncture; COMPLEMENTARY MEDICINE; Colorectal surgery; Functional Magnetic Resonance Imaging; Functional bowel disorders; Motility disorders
AB INTRODUCTION: Postoperative ileus (POI) is a prevalent complication following 
   abdominal surgeries, significantly compromising patients' quality of life and 
   imposing a socioeconomic burden. Electroacupuncture (EA), a widely used 
   therapeutic approach in China, has shown promise as an effective intervention for 
   POI. However, the neural mechanism underlying its therapeutic effects remains 
   unclear. Thus, this study aims to evaluate the efficacy of EA treatment for POI 
   and investigate its central mechanism by functional MRI (fMRI). METHODS AND 
   ANALYSIS: This randomised controlled clinical trial will be conducted across 
   three hospitals in China. A total of 50 eligible patients with colorectal cancer 
   scheduled for elective laparoscopic surgery will be randomly assigned to either 
   the EA or sham electroacupuncture (SA) group in a 1:1 ratio. All patients will 
   undergo 5 sessions of 30 min EA or SA over 5 consecutive days post-surgery (once 
   daily). Resting-state fMRI (rs-fMRI) scans will be performed at baseline and the 
   end of treatment to examine brain functional changes related to EA treatment. The 
   primary outcome is the time to first defecation. Secondary outcomes include the 
   time to first flatus, ambulation, tolerability of semiliquid and solid food; 
   length of postoperative hospital stay; severity of postoperative pain, abdominal 
   distension and nausea; frequency of postoperative nausea and vomiting episodes; 
   rate of readmission. Postoperative complications will be monitored and documented 
   throughout the trial duration. Credibility and expectancy evaluation, along with 
   blinding assessment, will be conducted after the first treatment session. 
   Pearson/Spearman correlation analysis will be performed to determine the 
   relationship between clinical variables and rs-fMRI metrics. ETHICS AND 
   DISSEMINATION: This protocol has been approved by the ethics committees of 
   Beijing University of Chinese Medicine (number 2024BZYLL0113), Cancer Hospital 
   Chinese Academy of Medical Sciences (number 24/323-4603), Beijing Friendship 
   Hospital Affiliated to Capital Medical University (number 2024-P2-081-01) and 
   Beijing Chaoyang Huanxing Cancer Hospital (number 2024-011-02). Participants will 
   sign the paper-based informed consent form before enrolment. The results will be 
   disseminated through peer-reviewed publications. TRIAL REGISTRATION NUMBER: 
   ITMCTR2024000504.
C1 International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciencesand Peking Union Medical College, Beijing, China.
   Department of General Surgery, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China.
   National Clinical Research Center for Digestive Diseases, Beijing, China.
   State Key Lab of Digestive Health, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China.
   Department of Surgery, Huanxing Cancer Hospital, Beijing, China.
   Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking UnionMedical College, Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China.
   School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China wangx@bucm.edu.cn 1254614551@qq.com.
   International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing, China wangx@bucm.edu.cn 1254614551@qq.com.
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD JAN 1
PY 2026
VL 15
IS 12
BP e108722
EP e108722
DI 10.1136/bmjopen-2025-108722 
PG 1
WC Humans; Electroacupuncture; methods; Ileus; therapy; Postoperative Complications; therapy; Magnetic Resonance Imaging; Colorectal Neoplasms; surgery; Multicenter Studies as Topic; China; Randomized Controlled Trials as Topic; Laparoscopy; adverse effects; Neuroimaging; Female; Male; Treatment Outcome; Middle Aged; Adult
UT PubMed:41475813
PM 41475813
DA 2026-01-01
ER

PT J
AU Paley, C
AF Paley, Carole
TI Acupuncture for the treatment of cancer pain: a systematic review. Response to 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Letter
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD JAN 12
PY 2013
VL 21
IS 5
BP 1217
EP 1217
DI 10.1007/s00520-012-1704-4 
PG 0
WC Acupuncture Therapy; methods; Humans; Pain; etiology; Pain Management; methods
UT PubMed:23306936
PM 23306936
DA 2013-01-12
ER

PT J
AU Xia, FY
   Liu, Y
   Zhong, Y
   He, XQ
   Yu, YL
   Li, HL
   Zhang, XY
AF Xia, Fei-Yan
   Liu, Yu
   Zhong, Yan
   He, Xi-Qin-Bing
   Yu, Yi-Lin
   Li, Han-Lin
   Zhang, Xin-Yi
TI [Effect of electroacupuncture on cannabinoid-related receptor CB2R and TRPV1 and 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Cannabinoid receptor type 2; Electroacupuncture; Microglia; Neuroinflammation; Pain hyperalgesia; Primary dysmenorrhea; Transient receptor potential vanilloid 1
AB OBJECTIVES: To observe the effect of electroacupuncture (EA) on the expression of 
   cannabinoid receptor type 2 (CB2R), atypical cannabinoid receptor transient 
   receptor potential vanilloid 1 (TRPV1), and spinal microglial polarization in 
   rats with primary dysmenorrhea (PDM), so as to explore the underlying mechanism 
   of EA alleviating PDM pain hyperalgesia. METHODS: Thirty female SD rats were 
   randomly divided into control, model, and EA groups (n=10 rats per group). The 
   PDM model was established by subcutaneous injection of estradiol diphenhydrate 
   combined with intraperitoneal injection of oxytocin. Rats in the EA group were 
   treated with EA (50 Hz) at "Guanyuan" (CV4) and bilateral "Sanyinjiao" (SP6) for 
   20 min, once a day for 10 consecutive days. The number of writhing, writhing 
   score, and writhing latency were observed. The uterine histopathological changes 
   were observed by H.E. staining. The contents of prostaglandin F2α (PGF2α), 
   prostaglandin E2 (PGE2) in serum and interleukin-6 (IL-6), interleukin-1β 
   (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) in spinal 
   cord were detected by ELISA. The protein expressions of CB2R and TRPV1 in spinal 
   cord and uterus, and inducible nitric oxide synthase (iNOS) and arginase-1 (Arg1) 
   in spinal cord were detected by Western blot. RESULTS: Compared with the control 
   group, the number and score of writhing, pathological injury score, contents of 
   PGF2α and ratio of PGF2α/PGE2 in serum and IL-1β, TNF-α and IL-6 contents in 
   spinal cord, the protein expressions of TRPV1 in both uterine and spinal cord, 
   and iNOS in spinal cord were significantly increased in the model group 
   (P<0.001), while contents of PGE2 in serum and IL-10 in spinal cord, the 
   expression levels of CB2R in both uterine and spinal cord, and Arg1 in spinal 
   cord were significantly decreased (P<0.001). In comparison with the model group, 
   the number of writhing, pathological injury score, contents of PGF2α and ratio of 
   PGF2α/PGE2 in serum and IL-1β, TNF-α and IL-6 contents in spinal cord, the 
   protein expressions of TRPV1 in both uterine and spinal cord and iNOS in spinal 
   cord were obviously decreased (P<0.001, P<0.05, P<0.01), whereas the writhing 
   latency was considerably prolonged (P<0.05), with elevated contents of PGE2 in 
   serum and IL-10 in spinal cord, and elevated protein expression levels of CB2R in 
   both uterine and spinal cord, and Arg1 in spinal cord (P<0.01, P<0.001) in the EA 
   group. H.E. staining showed degeneration, swelling, and necrosis of endometrial 
   epithelial cells, dilation of glands, stromal hyperemia, and granulocyte 
   infiltration in the model group, which were relatively milder in the EA group. 
   CONCLUSIONS: EA can alleviate uterine inflammatory response, pathological damage 
   and pain sensitization in PDM rats, which may be related to activating peripheral 
   and central CB2R expression, inhibiting TRPV1 expression, promoting spinal cord 
   microglia polarization from M1 to M2, thus reducing neuroinflammation.
C1 Hunan University of Chinese Medicine, Changsha 410208, China.
   Hunan University of Chinese Medicine, Changsha 410208, China. 125790602@qq.com.
   Hunan University of Chinese Medicine, Changsha 410208, China.
   Hunan University of Chinese Medicine, Changsha 410208, China.
   Hunan University of Chinese Medicine, Changsha 410208, China.
   Hunan University of Chinese Medicine, Changsha 410208, China.
   Hunan University of Chinese Medicine, Changsha 410208, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD NOV 20
PY 2025
VL 50
IS 11
BP 1248
EP 1256
DI 10.13702/j.1000-0607.20250615 
PG 8
WC Animals; Electroacupuncture; Female; TRPV Cation Channels; genetics; Rats; Receptor, Cannabinoid, CB2; genetics; Rats, Sprague-Dawley; Dysmenorrhea; therapy; Humans; Microglia; metabolism; Acupuncture Points; Spinal Cord; metabolism
UT PubMed:41261023
PM 41261023
DA 2025-11-20
ER

PT J
AU Zhang, JQ
   Xue, FS
   Meng, FM
   Li, RP
AF Zhang, Jia Qiang
   Xue, Fu Shan
   Meng, Fan Min
   Li, Rui-Ping
TI Assessing the anaesthetic and analgesic effects of electroacupuncture in patients 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Letter
C1 Department of Anesthesiology, Henan Provincial People's Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
   Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic ofChina.
   Department of Anesthesiology, Henan Provincial People's Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
   Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic ofChina.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD JUL 17
PY 2015
VL 34
IS 1
BP 69
EP 70
DI 10.1136/acupmed-2015-010880 
PG 1
WC Acupuncture Analgesia; Anesthetics; administration & dosage; Female; Humans; Male; Pain, Postoperative; therapy; Sufentanil; administration & dosage; Supratentorial Neoplasms; surgery; Transcutaneous Electric Nerve Stimulation
UT PubMed:26177686
PM 26177686
DA 2015-07-17
ER

PT J
AU Lee, JH
   Li, DX
   Yoon, H
   Go, D
   Quan, FS
   Min, BI
   Kim, SK
AF Lee, Ji-Hye
   Li, Dong Xing
   Yoon, Heera
   Go, Donghyun
   Quan, Fu Shi
   Min, Byung-Il
   Kim, Sun Kwang
TI Serotonergic mechanism of the relieving effect of bee venom acupuncture on 
SO BMC complementary and alternative medicine
LA English
DT Journal Article
AB BACKGROUND: Oxaliplatin, an important chemotherapy drug for advanced colorectal 
   cancer, often induces peripheral neuropathy, especially cold allodynia. Our 
   previous study showed that bee venom acupuncture (BVA), which has been 
   traditionally used in Korea to treat various pain symptoms, potently relieves 
   oxaliplatin-induced cold allodynia in rats. However, the mechanism for this 
   anti-allodynic effect of BVA remains poorly understood. We investigated whether 
   and how the central serotonergic system, a well-known pathway for acupuncture 
   analgesia, mediates the relieving effect of BVA on cold allodynia in 
   oxaliplatin-injected rats. METHODS: The behavioral signs of cold allodynia in 
   Sprague-Dawley (SD) rats were induced by a single injection of oxaliplatin (6 
   mg/kg, i.p.). Before and after BVA treatment, the cold allodynia signs were 
   evaluated by immersing the rat's tail into cold water (4°C) and measuring the 
   withdrawal latency. For BVA treatment, a diluted BV (0.25 mg/kg) was 
   subcutaneously administered into Yaoyangguan (GV3) acupoint, which is located 
   between the spinous processes of the fourth and the fifth lumbar vertebra. 
   Serotonin was depleted by a daily injection of DL-p-chlorophenylalanine (PCPA, 
   150 mg/kg, i.p.) for 3 days. The amount of serotonin in the spinal cord was 
   measured by ELISA. Serotonergic receptor antagonists were administered 
   intraperitoneally or intrathecally before BVA treatment. RESULTS: The serotonin 
   levels in the spinal cord were significantly increased by BVA treatment and such 
   increase was significantly reduced by PCPA. This PCPA pretreatment abolished the 
   relieving effect of BVA on oxaliplatin-induced cold allodynia. Either of 
   methysergide (mixed 5-HT1/5-HT2 receptor antagonist, 1 mg/kg, i.p.) or MDL-72222 
   (5-HT3 receptor antagonist, 1 mg/kg, i.p) blocked the anti-allodynic effect of 
   BVA. Further, an intrathecal injection of MDL-72222 (12 μg) completely blocked 
   the BVA-induced anti-allodynic action, whereas NAN-190 (5-HT1A receptor 
   antagonist, 15 μg, i.t.) or ketanserin (5-HT2A receptor antagonist, 30 μg, i.t.) 
   did not. CONCLUSIONS: These results suggest that BVA treatment alleviates 
   oxaliplatin-induced acute cold allodynia in rats via activation of the 
   serotonergic system, especially spinal 5-HT3 receptors. Thus, our findings may 
   provide a clinically useful evidence for the application of BVA as an alternative 
   therapeutic option for the management of peripheral neuropathy, a dose-limiting 
   side effect that occurs after an administration of oxaliplatin.
C1 Department of East-west Medicine, Graduate School, Kyung Hee University, Seoul 130-701, Republic of Korea. skkim77@khu.ac.kr.
NR 0
TC 0
SN 1472-688
EI 
J9 BMC Complement Altern Med
PD DEC 8
PY 2014
VL 14
IS 
BP 471
EP 471
DI 10.1186/1472-6882-14-471 
PG 0
WC Acupuncture Analgesia; Acupuncture Points; Animals; Apitherapy; Bee Venoms; pharmacology; Cold Temperature; Fenclonine; pharmacology; Hyperalgesia; chemically induced; Ketanserin; pharmacology; Male; Neuralgia; drug therapy; Organoplatinum Compounds; Oxaliplatin; Peripheral Nervous System Diseases; drug therapy; Piperazines; pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; metabolism; Serotonin; metabolism; Serotonin 5-HT3 Receptor Agonists; pharmacology; Serotonin Antagonists; pharmacology; Spinal Cord; drug effects; Tropanes; pharmacology
UT PubMed:25481535
PM 25481535
DA 2014-12-08
ER

PT J
AU Mohanty, S
   Shrestha, RL
AF Mohanty, Sriloy
   Shrestha, Rabin Lal
TI Effect of Electroacupuncture Rehabilitation in Transverse Myelitis: A Case 
SO Journal of acupuncture and meridian studies
LA English
DT Journal Article
DE acupuncture; rehabilitation; transverse myelitis; yoga
AB A 32-year-old male diagnosed with transverse myelitis in 2013 came to our clinic 
   in 2015 with complaints of paraplegia, sensory disturbances, pain, exertional 
   dyspnea, poor quality of sleep, emotional instability, and depression. This was a 
   recurrent attack that had been exacerbated by post-traumatic stress. Owing to 
   pain and functional disabilities, he was struggling to actively participate in 
   the treatment modalities offered at our center. A modified protocol of 
   electroacupuncture was planned for a period of 21 days, every day, with each 
   session lasting for 30 minutes. Assessments based on the brief version of World 
   Health Organization Brief Quality of Life (WHO Brief QOL) questionnaire, 
   Pittsburgh sleep quality index, visual analog scale, and a disease-specific 
   physical examination showed momentous improvement in functional health status as 
   well as mental well-being. The quality of life showed significant improvement 
   particularly in the physical and psychological dimensions of WHO Brief QOL. The 
   patient reported a reduction in pain, dyspnea, and fatigue accompanied by an 
   improvement in the quality of sleep and mood. This case report suggests that 
   acupuncture can play a vital role in amelioration of symptoms, thereby improving 
   the health status in patients with transverse myelitis.
C1 Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, Karnataka, India. 
   SDM College of Naturopathy and Yogic Sciences, Ujire, Karnataka, India.
EM sriloy21@gmail.com
NR 0
TC 0
SN 2093-815
EI 
J9 J Acupunct Meridian Stud
PD SEP 12
PY 2017
VL 10
IS 4
BP 286
EP 289
DI 10.1016/j.jams.2017.06.005 
PG 3
WC Adult; Electroacupuncture; Heart Rate; Humans; Male; Myelitis, Transverse; rehabilitation; Yoga
UT PubMed:28889845
PM 28889845
DA 2017-09-12
ER

PT J
AU Schumann, S
   Lauche, R
   Hohmann, C
   Zirbes, T
   Dobos, G
   Saha, FJ
AF Schumann, Stefan
   Lauche, Romy
   Hohmann, Claudia
   Zirbes, Thomas
   Dobos, Gustav
   Saha, Felix Joyonto
TI [Development of lipoma following a single cupping massage - a case report].
SO Forschende Komplementarmedizin (2006)
LA ger
DT Journal Article
AB BACKGROUND: The cupping massage is a form of bloodless cupping. This type of 
   cupping is particularly used to treat muscular tension and musculoskeletal pain, 
   such as chronic neck pain; however the data records on mechanisms and potential 
   side effects are not satisfactory. CASE REPORT: In a study on the effectiveness 
   of cupping massage in patients with chronic neck pain, one patient showed a 
   formation of a lipoma in the cupping area after the first treatment session. 
   CONCLUSION: Because of the short time interval between therapy and development of 
   the lipoma, a primary cause is not realistic. This adverse event has not been 
   described in the literature before, and the present report describes the case in 
   summary.
C1 Lehrstuhl für Naturheilkunde der Alfried Krupp von Bohlen und Halbach-Stiftung, Universität Duisburg-Essen, Deutschland.
NR 0
TC 0
SN 1661-412
EI 
J9 Forsch Komplementmed
PD SEP 12
PY 2012
VL 19
IS 4
BP 202
EP 5
DI 10.1159/000341869 
PG -197
WC Acupuncture Therapy; adverse effects; Aged; Chronic Disease; Clinical Trials as Topic; Diagnosis, Differential; Female; Humans; Lipoma; diagnosis; Massage; adverse effects; Neck Pain; therapy; Shoulder; surgery; Soft Tissue Neoplasms; diagnosis; Ultrasonography
UT PubMed:22964987
PM 22964987
DA 2012-09-12
ER

PT J
AU Huang, W
   Yu, TY
   Long, WF
   Xiao, JB
AF Huang, Wei
   Yu, Ting-Yu
   Long, Wen-Fei
   Xiao, Jian-Bin
TI [Application of Transcutaneous Electrical Acupoint Stimulation Combined with 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Clinical trial; Enhanced recovery after surgery; Laparoscopic colorectal cancer resection; Transcutaneous electrical acupoint stimulation; Transversus abdominis plane block
AB OBJECTIVE: To explore the effect of transcutaneous electrical acupoint 
   stimulation (TEAS) combined with transversus abdominis plane (TAP) block in the 
   enhanced recovery after surgery (ERAS) in patients undergoing laparoscopic 
   colorectal cancer resection (LCCR). METHODS: A total of 101 patients undergoing 
   LCCR were randomly divided into three groups: control (n＝34), TAP (n＝35) and 
   TEAS＋TAP (n＝32). Conventional perioperative anesthesia management of the 3 groups 
   was performed according to the ERAS guidelines. All the patients experienced 
   patient controlled epidural analgesia (PCEA), and those of the TAP and TEAS＋TAP 
   groups received TAP block by injection of 0.3% Roperca hydrochloride (15 mL) into 
   the space between the internal oblique and the transverse abdominis after 
   induction of anesthesia. For patients of the TEAS＋TAP group, TEAS (2 Hz/10 Hz, an 
   endurable stimulation strength) was applied to bilateral Zusanli (ST 36) from 30 
   min before anesthesia to the end of the surgery. The blood glucose value and 
   dosage of Remifentanil used were recorded. The pain severity was assessed at 4, 
   12, 24 and 48 h after surgery by using visual analogue scale (VAS). Moreover, 
   postoperative anal exhaust time, postoperative oral feeding time, postoperative 
   first ambulation time and postoperative hospital stay length were recorded. 
   RESULTS: The total dosages of Remifentanil used during surgery, and the blood 
   glucose levels were significantly lower in the TAP and TEAS＋TAP groups than in 
   the control group (P<0.05), but had no significant differences between the TAP 
   and TEAS＋TAP groups (P>0.05). The VAS scores of the TAP and TEAS＋TAP groups were 
   considerably lower than those of the control group at 4, 12, 24 and 48 h after 
   surgery (P<0.05, except 48 h of TAP group). Of the 34, 35 and 32 cases in the 
   control, TAP and TEAS＋TAP groups, 5(14.7%), 3(8.6%) and 1(3.1%) on the 1(st) day 
   post-surgery, and 2(5.9%), 0(0) and 0(0) on the 2(nd) day after surgery 
   experienced nausea and vomiting. The postoperative anal exhaust time and 
   postoperative oral feeding time were significantly earlier in both TAP and 
   TEAS＋TAP groups than in the control group (P<0.05), and the exhaust time of the 
   TEAS＋TAP group was even earlier than that of the TAP group (P<0.05). No 
   significant differences were found among the 3 groups in the postoperative 
   ambulation time and postoperative hospitalization time (P>0.05). CONCLUSION: TEAS 
   combined with TAP block analgesia is superior to simple TAP block analgesia in 
   relieving postoperative pain, shortening the recovery time of gastrointestinal 
   function and promoting postoperative rehabilitation in patients undergoing LCCR.
C1 The Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China.
   The Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China.
   The Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China.
   The Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD OCT 27
PY 2018
VL 43
IS 10
BP 611
EP 5
DI 10.13702/j.1000-0607.180005 
PG -606
WC Abdominal Muscles; Acupuncture Points; Analgesics, Opioid; Colorectal Neoplasms; therapy; Humans; Laparoscopy; Nerve Block; Pain Measurement; Pain, Postoperative
UT PubMed:30365254
PM 30365254
DA 2018-10-27
ER

PT J
AU Hu, H
   Li, Z
   Zhang, Y
   Gao, H
AF Hu, Hantong
   Li, Zengtu
   Zhang, Yajun
   Gao, Hong
TI Comment on: Transcutaneous electrical acupoint stimulation before surgery reduces 
SO Journal of clinical anesthesia
LA English
DT Letter
C1 Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
   Department of Massage, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China. 
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
EM qtgh@vip.qq.com
NR 0
TC 0
SN 1873-452
EI 
J9 J Clin Anesth
PD SEP 5
PY 2021
VL 75
IS 
BP 110501
EP 110501
DI 10.1016/j.jclinane.2021.110501 
PG 0
WC Acupuncture Points; Breast Neoplasms; Chronic Pain; etiology; Female; Humans; Mastectomy; adverse effects; Transcutaneous Electric Nerve Stimulation
UT PubMed:34481364
PM 34481364
DA 2021-09-05
ER

PT J
AU Tam, KW
   Chen, L
   Lin, CC
   Huang, TW
   Kuan, YC
   Huang, YH
   Chen, HC
   Kao, CY
   Su, CM
AF Tam, Ka-Wai
   Chen, Lawrence
   Lin, Chao-Chun
   Huang, Tsai-Wei
   Kuan, Yi-Chun
   Huang, Yao-Hsien
   Chen, Hung-Chou
   Kao, Chun-Yu
   Su, Chih-Ming
TI Reply to correspondence concerning "Acupuncture on aromatase inhibitor-induced 
SO Breast (Edinburgh, Scotland)
LA English
DT Letter
C1 Division of General Surgery, Department of General Surgery, Shuang Ho Hospital, Taipei Medical University, Taiwan
   Center for Evidence-Based Health Care, ShuangHo Hospital, Taipei Medical University, Taiwan. 
   Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, Taiwan.
   Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, Taiwan.
   School of Nursing, College of Nursing, Taipei Medical University, Taiwan.
   Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, Taiwan
   Department of Neurology, Shuang Ho Hospital, Taipei MedicalUniversity, Taiwan.
   Department of Neurology, Shuang Ho Hospital, Taipei Medical University, Taiwan.
   Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, Taiwan
   Department of Physical Medicine and Rehabilitation, Shuang HoHospital, Taipei Medical University, Taiwan.
   Division of General Surgery, Department of General Surgery, Shuang Ho Hospital, Taipei Medical University, Taiwan.
   Division of General Surgery, Department of General Surgery, Shuang Ho Hospital, Taipei Medical University, Taiwan.
EM elvintam@h.tmu.edu.tw
NR 0
TC 0
SN 1532-308
EI 
J9 Breast
PD MAR 13
PY 2019
VL 45
IS 
BP 119
EP 120
DI 10.1016/j.breast.2019.02.005 
PG 1
WC Acupuncture Therapy; Aromatase; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Humans
UT PubMed:30857771
PM 30857771
DA 2019-03-13
ER

PT J
AU Li, SQ
   Meng, LH
   Wang, YC
AF Li, Shu-Qing
   Meng, Ling-Hui
   Wang, Yun-Cang
TI [Acupuncture at Hegu (LI 4) for 18 cases of pain during CT-guided percutaneous 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUN 2
PY 2012
VL 32
IS 5
BP 451
EP 451
DI 
PG 0
WC Acupuncture Analgesia; Acupuncture Points; Adult; Aged; Aged, 80 and over; Catheter Ablation; Female; Humans; Liver Neoplasms; surgery; Male; Middle Aged; Pain Management
UT PubMed:22650137
PM 22650137
DA 2012-06-02
ER

PT J
AU Chen, XM
   Pang, LN
   Ke, YC
   Huang, QL
   Lan, YY
   Yu, XM
   Ye, XQ
   Wang, ZF
AF Chen, Xiao-Mei
   Pang, Li-Na
   Ke, Yi-Chen
   Huang, Qiu-Ling
   Lan, Yan-Yan
   Yu, Xiang-Mei
   Ye, Xiao-Qian
   Wang, Zhi-Fu
TI [Exploring the mechanism of wrist-ankle acupuncture in treating 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Chemotherapy-induced neuropathic pain; Electroacupuncture; Wrist-ankle acupuncture; α7 nicotinic acetylcholine receptor / Janus kinase 2/signal transducer and 
AB OBJECTIVES: To investigate the effect of wrist-ankle acupuncture on the α7 
   nicotinic acetylcholine receptor (α7nAChR)/Janus kinase 2 (JAK2)/signal 
   transducer and activator of transcription 3 (STAT3) signaling pathway in the 
   spinal dorsal horn of mice with chemotherapy-induced neuropathic pain (CINP), and 
   to explore the mechanisms by which low-intensity wrist-ankle electroacupuncture 
   alleviates pain hypersensitivity in CINP mice. METHODS: C57BL/6 mice were 
   randomly divided into a blank group, a model group, a wrist-ankle acupuncture 
   group, and a wrist-ankle acupuncture + antagonist group, with 8 mice in each 
   group. A CINP model was established by intraperitoneal injection of paclitaxel (2 
   mg/kg). The wrist-ankle acupuncture group received electroacupuncture at the 
   "Lower 4" and "Lower 5" points in the wrist-ankle region for 30 min per session, 
   once every other day, for a total of 7 sessions. The wrist-ankle acupuncture + 
   antagonist group received intrathecal injections of the α7nAChR antagonist α-BGT 
   (0.5 μg/kg) on day 1, 7, and 13, in addition to acupuncture. The mechanical and 
   thermal pain thresholds were assessed using Von Frey filaments and hot plate 
   tests. The expression level of α7nAChR protein in the spinal dorsal horn (L4-L6) 
   was determined by Western blot. Immunofluorescence staining was used to detect 
   the expression of ionized calcium-binding adapter molecule 1 (Iba-1) in the 
   spinal dorsal horn. ELISA was used to measure the relative levels of 
   phosphorylated (p)-JAK2 and p-STAT3 in the spinal dorsal horn. Quantitative PCR 
   was used to detect the relative mRNA expression levels of tumor necrosis factor-α 
   (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). RESULTS: Compared with 
   the blank group, the model group exhibited decreased mechanical and thermal pain 
   thresholds (P<0.001), reduced α7nAChR protein expression (P<0.05), increased 
   Iba-1 expression (P<0.05), elevated relative contents of p-JAK2 and p-STAT3 
   (P<0.05), and increased mRNA expression levels of TNF-α, IL-1β, and IL-6 
   (P<0.05). Compared with the model group, the wrist-ankle acupuncture group showed 
   increased mechanical and thermal pain thresholds (P<0.05), elevated α7nAChR 
   protein expression (P<0.05), decreased Iba-1 expression (P<0.05), reduced 
   relative contents of p-JAK2 and p-STAT3 (P<0.05), and decreased mRNA expression 
   levels of TNF-α, IL-1β, and IL-6 (P<0.05). Compared with the wrist-ankle 
   acupuncture group, the wrist-ankle acupuncture + antagonist group showed 
   decreased mechanical and thermal pain thresholds (P<0.05), lower α7nAChR protein 
   expression (P<0.05), increased Iba-1 expression (P<0.05), higher relative 
   contents of p-JAK2 and p-STAT3 (P<0.05), and elevated mRNA expression levels of 
   TNF-α, IL-1β, and IL-6 (P<0.05). CONCLUSIONS: Wrist-ankle acupuncture may 
   alleviate pain hypersensitivity in CINP mice by regulating the α7nAChR/JAK2/STAT3 
   signaling pathway in the spinal dorsal horn, inhibiting microglial activation, 
   and reducing neuroinflammation.
C1 College of Acupuncture-Moxibustion and Tuina, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
   College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 
   College of Acupuncture-Moxibustion and Tuina, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
   College of Acupuncture-Moxibustion and Tuina, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
   College of Acupuncture-Moxibustion and Tuina, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
   College of Acupuncture-Moxibustion and Tuina, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
   College of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122.
   Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350122. 357635952@qq.com.
   College of Acupuncture-Moxibustion and Tuina, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China. 2007015@fjtcm.edu.cn.
   People's Hospital Affiliated to Fujian University of Traditional Chinese 
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUL 22
PY 2025
VL 50
IS 7
BP 735
EP 742
DI 10.13702/j.1000-0607.20241267 
PG 7
WC Animals; alpha7 Nicotinic Acetylcholine Receptor; genetics; Mice; Neuralgia; therapy; Humans; Mice, Inbred C57BL; Male; Spinal Cord Dorsal Horn; immunology; Acupuncture Points; STAT3 Transcription Factor; genetics; Acupuncture Therapy; Janus Kinase 2; genetics; Antineoplastic Agents; adverse effects; Paclitaxel; adverse effects; Signal Transduction; Electroacupuncture
UT PubMed:40691023
PM 40691023
DA 2025-07-22
ER

PT J
AU Wang, L
   Qin, Z
   Xu, M
   Chen, C
AF Wang, Lingya
   Qin, Zhouxiu
   Xu, Mengfei
   Chen, Caifang
TI The efficacy of foot acupoint massage combined with medium-frequency electrical 
SO Medicine
LA English
DT Journal Article
DE colorectal tumor; foot acupoint massage; gastrointestinal function; medium-frequency electrical stimulation
AB Gastrointestinal (GI) dysfunction is a common complication after colorectal 
   cancer surgery, often leading to prolonged hospitalization and reduced quality of 
   life. This study aims to evaluate the impact of combining foot acupoint massage 
   (FAM) and medium-frequency electrical stimulation (MFES) on the recovery of GI 
   function after colorectal tumor surgery. A total of 135 patients were 
   retrospectively categorized into 3 groups according to the nursing interventions 
   recorded in their medical records: the control group (routine care), the FAM 
   group (routine care + FAM), and the FAM/MFES group (routine care + FAM + MFES), 
   with 45 patients in each group. The primary outcomes included postoperative pain 
   (Visual Analog Scale score), time to first flatus, time to first bowel movement, 
   time for bowel sounds to return, time to resume normal diet, abdominal distension 
   score, and the incidence of postoperative ileus. Compared with the other 2 
   groups, the FAM/MFES group showed superior results in postoperative pain, time to 
   first flatus, time to first bowel movement, time for bowel sounds to return, and 
   time to resume normal diet (P < .05). The abdominal distension score was also 
   significantly lower in the FAM/MFES group (P = .016). However, there was no 
   significant difference in the incidence of postoperative ileus between the groups 
   (P = .240). The combination of FAM and MFES significantly promotes GI function 
   recovery after colorectal surgery, providing a promising adjunctive treatment 
   approach for postoperative care.
C1 Department of General Surgery, Jiading District Central Hospital, Shanghai Health Medical College, Shanghai, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JAN 7
PY 2026
VL 105
IS 1
BP e46359
EP e46359
DI 10.1097/MD.0000000000046359 
PG 1
WC Humans; Massage; methods; Male; Female; Retrospective Studies; Middle Aged; Colorectal Neoplasms; surgery; Acupuncture Points; Aged; Recovery of Function; Postoperative Complications; prevention & control; Electric Stimulation Therapy; methods; Foot; Treatment Outcome; Pain, Postoperative; Combined Modality Therapy
UT PubMed:41496045
PM 41496045
DA 2026-01-07
ER

PT J
AU Zhang, YP
   Ru, QJ
AF Zhang, Yue-Ping
   Ru, Qing-Jing
TI [Cases of postoperative pain of liver cancer after transcatheter arterial 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
C1 iamzhangyueping@sina.com
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD DEC 5
PY 2013
VL 33
IS 9
BP 778
EP 778
DI 
PG 0
WC Acupuncture Analgesia; Acupuncture, Ear; Adult; Chemoembolization, Therapeutic; Humans; Liver Neoplasms; complications; Male; Pain, Postoperative; etiology
UT PubMed:24298763
PM 24298763
DA 2013-12-05
ER

PT J
AU Yuanqing, P
   Yong, T
   Haiqian, L
   Gen, C
   Shen, X
   Dong, J
   Qi, C
   Miaomiao, Q
AF Yuanqing, Pan
   Yong, Tang
   Haiqian, Liang
   Gen, Chen
   Shen, Xiping
   Dong, Jin
   Qi, Cui
   Miaomiao, Qi
TI Acupuncture for Hormone Therapy-Related Side Effects in Breast Cancer Patients: A 
SO Integrative cancer therapies
LA English
DT Journal Article
DE GRADE; acupuncture; alternative therapy; breast cancer; meta-analysis
AB Purpose: To determine the efficacy of acupuncture on the management of hormone 
   therapy-related side effects in breast cancer patients. Methods: Randomized 
   controlled trials of acupuncture versus a control or placebo in breast cancer 
   patients that examined reductions in therapy-related side effects were retrieved 
   from PubMed, EMBASE, Web of Science, and the Cochrane Library through April 2020. 
   Data on patient symptoms (hot flashes, fatigue, pain, stiffness, and 
   gastrointestinal symptoms), physical capacity, cytokines, and general 
   psychosomatic well-being were analyzed. We evaluated and analyzed the quality of 
   all included studies with the 5.2 Cochrane Handbook standards using Stata 
   software (version 10.0) and Revman software (version 5.2), respectively. We 
   assessed the risk of bias using the Cochrane Risk of Bias tool and evaluated the 
   quality of evidence using the GRADE (Grading of Recommendations, Assessment, 
   Development, and Evaluations) approach. Results: The pooled results suggested 
   that acupuncture led to moderate improvements in hot flashes, fatigue, and 
   stiffness. No significant differences were observed in pain, gastrointestinal 
   symptoms, Kupperman index scores, Overall quality of life, tumor necrosis factor 
   levels, and interleukin levels. Conclusions: Evidence for outcome indicators of 
   symptom management were downgraded by the GRADE system for inconsistency, 
   indirectness, and imprecision in the included RCTs. Nonetheless, acupuncture is a 
   moderately appropriate alternative therapy for hormone therapy-related side 
   effects in breast cancer patients. However, it still lacks large-sample, 
   multicenter, prospective RCTs. Future research should focus on standardizing 
   comparison groups and treatment methods, be at least single-blinded, assess 
   biologic mechanisms, have adequate statistical power, and involve multiple 
   acupuncturists.
C1 Guilin Medical University, Campbell China Network, Guilin, China.
   The Affiliated Tumor Hospital of Tianjin Medical University, Tianjin, China.
   Characteristic Medical Center of Chinese people's Armed Police Force, Tianjin, China.
   Guilin Medical University, Campbell China Network, Guilin, China.
   Lanzhou University, Gansu, China.
   Tianjin Pingjin Hospital, Tianjin, China.
   The First Affiliated Hospital of Lanzhou University, Gansu, China.
   Lanzhou University, Gansu, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD JUL 29
PY 2020
VL 19
IS 
BP 1534735420940394
EP 1534735420940394
DI 10.1177/1534735420940394 
PG 1
WC Acupuncture Therapy; Breast Neoplasms; drug therapy; Female; Hormones; Humans; Multicenter Studies as Topic; Prospective Studies; Quality of Life
UT PubMed:32718258
PM 32718258
DA 2020-07-29
ER

PT J
AU Dymackova, R
   Kazda, T
   Slavik, M
   Selingerova, I
   Slampa, P
   Slama, O
AF Dymackova, Radana
   Kazda, Tomas
   Slavik, Marek
   Selingerova, Iveta
   Slampa, Pavel
   Slama, Ondrej
TI Acupuncture in the treatment of acute toxicity during and after head and neck 
SO Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, 
LA English
DT Journal Article
DE acupuncture; cancer; head and neck; radiotherapy; toxicity
AB AIMS: The aim of this investigator-initiated prospective randomized open-label 
   single institutional trial is to evaluate the role of acupuncture in the 
   treatment of acute skin and mucosal toxicity, xerostomia, and perception of 
   taste, pain, and nausea related to curative and adjuvant (chemo)radiotherapy of 
   head and neck cancer. This paper reports pilot data of the first 30 enrolled 
   patients. METHODS: Patients were randomized to undergo standard of care 
   radiotherapy ± chemotherapy and support care defined by our institutional 
   standard operating procedures alone or in the combination with acupuncture which 
   was initiated with the first signs of any toxicity. RESULTS: Fifteen patients 
   were enrolled in both arms and all finished the treatment as planned.The median 
   pain was significantly lower in the acupuncture arm (median 1.6 points vs. 2.5 
   points on a 10-item Likert scale; P=0.035) as well as duration of acute pain 
   (median 31 days vs. 54 days; P=0.031). Patients with acupuncture had 
   significantly shorter duration of acute skin (median 44 days vs. 109 days; 
   P<0.001) and mucosal toxicity (median 34 days vs. 109 days; P<0.001) with no 
   difference in grading of toxicity (median grade 1.6 vs. 1.5; P=0.701 and median 
   grade 1.4 vs. 1.6; P=0.204 for skin and mucosa, respectively). No significant 
   difference was found for other toxicity domains, with the exception of salivation 
   toxicity which was significantly lower in acupuncture arm (median grade 1.3 vs. 
   1.7; P=0.048). CONCLUSION: In this interim analysis, acupuncture leads to lower 
   pain andfaster disappearance of skin and mucosal toxicity after 
   (chemo)radiotherapy of head and neck cancer. Description and validation of 
   acupuncture using scientific approaches will further enhance acceptance of this 
   method by both patients and health care providers. TRIAL REGISTRATION: 
   Clinicaltrials.gov - NCT03751566.
C1 Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
   Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 
   Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
   Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 
   Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
   Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 
   Regional Center for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.
   Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
   Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 
   Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
   Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty 
NR 0
TC 0
SN 1804-752
EI 
J9 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
PD JUL 1
PY 2020
VL 164
IS 4
BP 454
EP 460
DI 10.5507/bp.2020.021 
PG 6
WC Acupuncture Therapy; methods; Aged; Czech Republic; Female; Head and Neck Neoplasms; radiotherapy; Humans; Male; Middle Aged; Prospective Studies; Radiotherapy; adverse effects; Skin; radiation effects; Skin Diseases; etiology
UT PubMed:32597419
PM 32597419
DA 2020-07-01
ER

PT J
AU Garland, SN
   Xie, SX
   DuHamel, K
   Bao, T
   Li, Q
   Barg, FK
   Song, S
   Kantoff, P
   Gehrman, P
   Mao, JJ
AF Garland, Sheila N
   Xie, Sharon X
   DuHamel, Kate
   Bao, Ting
   Li, Qing
   Barg, Frances K
   Song, Sarah
   Kantoff, Philip
   Gehrman, Philip
   Mao, Jun J
TI Acupuncture Versus Cognitive Behavioral Therapy for Insomnia in Cancer Survivors: 
SO Journal of the National Cancer Institute
LA English
DT Journal Article
AB BACKGROUND: Insomnia is a common and debilitating disorder experienced by cancer 
   survivors. Although cancer survivors express a preference for using 
   nonpharmacological treatment to manage insomnia, the comparative effectiveness 
   between acupuncture and Cognitive Behavioral Therapy for Insomnia (CBT-I) for 
   this disorder is unknown. METHODS: This randomized trial compared 8 weeks of 
   acupuncture (n = 80) and CBT-I (n = 80) in cancer survivors. Acupuncture involved 
   stimulating specific points on the body with needles. CBT-I included sleep 
   restriction, stimulus control, cognitive restructuring, relaxation training, and 
   education. We measured insomnia severity (primary outcome), pain, fatigue, mood, 
   and quality of life posttreatment (8 weeks) with follow-up until 20 weeks. We 
   used linear mixed-effects models for analyses. All statistical tests were 
   two-sided. RESULTS: The mean age was 61.5 years and 56.9% were women. CBT-I was 
   more effective than acupuncture posttreatment (P < .001); however, both 
   acupuncture and CBT-I produced clinically meaningful reductions in insomnia 
   severity (acupuncture: -8.31 points, 95% confidence interval = -9.36 to -7.26; 
   CBT-I: -10.91 points, 95% confidence interval = -11.97 to -9.85) and maintained 
   improvements up to 20 weeks. Acupuncture was more effective for pain at the end 
   of treatment; both groups had similar improvements in fatigue, mood, and quality 
   of life and reduced prescription hypnotic medication use. CBT-I was more 
   effective for those who were male (P < .001), white (P = .003), highly educated 
   (P < .001), and had no pain at baseline (P < .001). CONCLUSIONS: Although both 
   treatments produced meaningful and durable improvements, CBT-I was more effective 
   and should be the first line of therapy. The relative differences in the 
   comparative effectiveness between the two interventions for specific groups 
   should be confirmed in future adequately powered trials to guide more tailored 
   interventions for insomnia.
NR 0
TC 0
SN 1460-210
EI 0027-887
J9 J Natl Cancer Inst
PD MAY 14
PY 2019
VL 111
IS 12
BP 1323
EP 1331
DI 10.1093/jnci/djz050 
PG 8
WC Acupuncture Therapy; adverse effects; Affect; Cancer Survivors; Cognitive Behavioral Therapy; statistics & numerical data; Confidence Intervals; Fatigue; therapy; Female; Humans; Male; Middle Aged; Neoplasms; complications; Quality of Life; Sleep Initiation and Maintenance Disorders; psychology; Socioeconomic Factors; Treatment Outcome
UT PubMed:31081899
PM 31081899
DA 2019-05-14
ER

PT J
AU Jang, S
   Ko, Y
   Sasaki, Y
   Park, S
   Jo, J
   Kang, NH
   Yoo, ES
   Park, NC
   Cho, SH
   Jang, H
   Jang, BH
   Hwang, DS
   Ko, SG
AF Jang, Soobin
   Ko, Youme
   Sasaki, Yui
   Park, Sunju
   Jo, Junyoung
   Kang, Na-Hoon
   Yoo, Eun-Sil
   Park, Nam-Chun
   Cho, Seong Hee
   Jang, Heejea
   Jang, Bo-Hyoung
   Hwang, Deok-Sang
   Ko, Seong-Gyu
TI Acupuncture as an adjuvant therapy for management of treatment-related symptoms 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Although randomized controlled trials have revealed the considerable 
   effectiveness of acupuncture in breast cancer patients, there have been no 
   studies exploring current acupuncture research trends for treatment induced 
   various symptoms in breast cancer patients. This review evaluated the 
   effectiveness of acupuncture for treatment-induced symptoms in breast cancer 
   patients. METHODS: We performed a systematic review and meta-analysis of the 
   literature regarding acupuncture to treat symptoms associated with breast cancer 
   therapies. The following databases were searched for relevant RCTs published 
   before June 2018: MEDLINE, EMBASE, the Cochrane Library, AMED, CINAHL, OASIS, 
   CNKI, and CiNii. RESULTS: Among the 19,483 records identified, 835 articles 
   remained after screening titles and abstracts. A total of 19 RCTs were included 
   in this qualitative synthesis. Among the studies, 8 explored climacteric 
   symptoms, 4 explored pain, 2 explored lymphedemas, 2 explored nausea and vomiting 
   and 3 investigated miscellaneous symptoms.explored miscellaneous symptoms due to 
   cancer treatments. Most of the studies reported that acupuncture can alleviate 
   various symptoms of breast cancer treatment. However, there is a lack of evidence 
   as to whether accupuncture can alleviate chemotherapy associated side effects 
   CONCLUSIONS:: Acupuncture may alleviate the treatment-related symptoms of breast 
   cancer; however, further studies are necessary to obtain conclusive evidence of 
   the effectiveness of acupuncture in treating breast cancer. REGISTRATION NUMBER: 
   CRD42018087813.
C1 Clinical Research Division, Korea Institute of Oriental Medicine
   1672 Yuseong-daero, Yuseong-gu, Daejeon.
   Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University
   26, Kyungheedae-ro, Hoegi-dong, Dongdaemun-gu, Seoul.
   Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University
   26, Kyungheedae-ro, Hoegi-dong, Dongdaemun-gu, Seoul.
   Department of Preventive Medicine, College of Korean Medicine, Daejeon University
   62 Daehak-ro, Dong-gu, Daejeon.
   Department of Korean Obstetrics and Gynecology, Conmaul Hospital of Korean Medicine, 110 Seochojungang-ro, Seocho-dong, Seocho-gu, Seoul.
   Department of Clinical Korean Medicine, Graduate School, Kyung-Hee University, 26, Kyungheedae-ro, Hoegi-dong, Dongdaemun-gu, Seoul.
   Department of Clinical Korean Medicine, Graduate School, Kyung-Hee University, 26, Kyungheedae-ro, Hoegi-dong, Dongdaemun-gu, Seoul.
   Department of Clinical Korean Medicine, Graduate School, Kyung-Hee University, 26, Kyungheedae-ro, Hoegi-dong, Dongdaemun-gu, Seoul.
   Department of Obstetrics and Gynecology, College of Korean Medicine, Dong-Shin University, 185, Geonjae-ro, Naju-si, Jeollanam-do.
   Women Cancer Center, Soram Korean medicine Hospital, 154-11, Samsung-dong, 06154, Gangnam-gu, Seoul, Republic of Korea.
   Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University
   26, Kyungheedae-ro, Hoegi-dong, Dongdaemun-gu, Seoul.
   Department of Preventive Medicine, College of Korean Medicine, Daejeon University
   62 Daehak-ro, Dong-gu, Daejeon.
   Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University
   26, Kyungheedae-ro, Hoegi-dong, Dongdaemun-gu, Seoul.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD DEC 18
PY 2020
VL 99
IS 50
BP e21820
EP e21820
DI 10.1097/MD.0000000000021820 
PG 1
WC Acupuncture Therapy; methods; Adult; Aged; Aged, 80 and over; Breast Cancer Lymphedema; therapy; Breast Neoplasms; pathology; Case-Control Studies; Evaluation Studies as Topic; Female; Hot Flashes; therapy; Humans; Middle Aged; Nausea; therapy; Pain Management; methods; Randomized Controlled Trials as Topic; Vomiting; therapy
UT PubMed:33327222
PM 33327222
DA 2020-12-18
ER

PT J
AU Guo, J
   Pei, L
   Chen, L
   Chen, H
   Gu, D
   Xin, C
   Peng, Y
   Sun, J
AF Guo, Jing
   Pei, Lixia
   Chen, Lu
   Chen, Hao
   Gu, Dongmei
   Xin, Chen
   Peng, Yongjun
   Sun, Jianhua
TI Research Trends of Acupuncture Therapy on Cancer Over the Past Two Decades: A 
SO Integrative cancer therapies
LA English
DT Journal Article
DE CiteSpace; VOSviewer; acupuncture therapy; bibliometric analysis; cancer
AB PURPOSE: Acupuncture has been used for managing cancer-related symptoms. However, 
   there are still few studies concerning the overall trends in acupuncture therapy 
   on cancer based on bibliometric analysis. This study aims to demonstrate the 
   current status and trends in this field over the past 2 decades. METHODS: 
   Articles were retrieved from the Web of Science from 2000 to 2019. CiteSpace was 
   used for co-authorship network of countries/institutions, dual-map analysis, and 
   detecting the keywords with citation bursts. VOSviewer was used to construct 
   networks based on co-authorship and co-citation analysis of authors, and 
   co-occurrence of keywords. RESULTS: A total of 927 articles and reviews were 
   included in the final analysis. The number of publications has steadily increased 
   with some fluctuations among years. The country and institution contributing most 
   to this field are the USA and Memorial Sloan Kettering Cancer Center. Mao JJ was 
   the most productive author and Molassiotis A ranked first in the cited authors. 
   The co-occurrence analysis revealed 5 clusters (including "clinical trials," 
   "clinical studies on chemotherapy/radiation-induced symptoms," "CAM therapy for 
   cancer," "clinical studies on vasomotor symptoms," and "systematic reviews"). 
   Most recent keyword bursts were "neuropathic pain," "arthralgia," "prevention," 
   "supportive care," and "integrative medicine". CONCLUSIONS: The annual 
   publication output would increase rapidly in the next decade, which shows a 
   promising future in this research field. Future research hotspots would focus on 
   the role of acupuncture in neuropathic pain, arthralgia, prevention, supportive 
   care, and integrative medicine.
C1 The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   Nanjing University of Chinese Medicine, Nanjing, China.
   The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
   The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD NOV 5
PY 2020
VL 19
IS 
BP 1534735420959442
EP 1534735420959442
DI 10.1177/1534735420959442 
PG 1
WC Acupuncture Therapy; Bibliometrics; Humans; Integrative Medicine; Neoplasms; therapy
UT PubMed:33143477
PM 33143477
DA 2020-11-05
ER

PT J
AU Chien, A
   Yang, CC
   Chang, SC
   Jan, YM
   Yang, CH
   Hsieh, YL
AF Chien, Andy
   Yang, Chen-Chia
   Chang, Sheng-Chi
   Jan, Yi-Min
   Yang, Ching-Hsiang
   Hsieh, Yueh-Ling
TI Ultrasound Acupuncture for Oxaliplatin-induced Peripheral Neuropathy in Patients 
SO PM & R : the journal of injury, function, and rehabilitation
LA English
DT Journal Article
AB BACKGROUND: Oxaliplatin is frequently used in the treatment of metastatic 
   colorectal cancer. However, peripheral neuropathy is a severe adverse effect of 
   oxaliplatin that may persist and impact quality of life. OBJECTIVE: To assess the 
   potential effects of ultrasound acupuncture for the alleviation of symptoms 
   related to oxaliplatin-induced peripheral neuropathy (OIPN) among patients with 
   metastatic colorectal cancer. DESIGN: Prospective cohort pilot study. SETTING: 
   Education and research hospital. PARTICIPANTS: Patients with a diagnosis of stage 
   II-IV colorectal cancer undergoing oxaliplatin-based treatment regimens who 
   experienced OIPN symptoms (n = 17). INTERVENTIONS: Pulsed therapeutic ultrasound 
   (1 MHz) at bilateral acupuncture points of PC6, PC7, BL60, and KI1 was 
   administered for 5 minutes per point daily for 12 days. MAIN OUTCOME 
   MEASUREMENTS: Pain Quality Assessment Scale (PQAS), Chemotherapy-induced 
   Neurotoxicity Questionnaire (CINQ), quantitative touch-detection threshold, 
   cold-trigger pain withdrawal latency, and quality of life (EORTC QLQ-C30) were 
   measured at baseline (day 0), pre-intervention (day 12, post wash-out period), 
   post-intervention (day 24), and final follow-up (day 54). A P value of less than 
   .05 was considered statistically significant. RESULTS: Scores of PQAS and CINQ 
   significantly improved after ultrasound acupuncture at post-intervention and 
   follow-up compared to both baseline and pre-intervention. Similar trends were 
   also observed for the quantitative sensory testing, where touch-detection 
   threshold significantly decreased and cold-trigger pain withdrawal latency 
   significantly increased after ultrasound acupuncture. Patients also showed an 
   improvement on quality of life outcomes as measured by QLQ-C30 post-intervention 
   and at follow-up. CONCLUSIONS: Ultrasound acupuncture could be an effective 
   intervention for OIPN symptoms for patients with colorectal cancer. However, 
   larger and randomized clinical trials with placebo controls are needed to confirm 
   such effects.
C1 Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan.
   Kao-An Rehabilitation and Pain Clinic, Taichung, Taiwan.
   Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan.
   Center for General Education, China Medical University, Taichung, Taiwan.
   Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan.
   Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan.
NR 0
TC 0
SN 1934-156
EI 
J9 PM R
PD MAR 14
PY 2020
VL 13
IS 1
BP 55
EP 65
DI 10.1002/pmrj.12361 
PG 10
WC Acupuncture Therapy; Colorectal Neoplasms; drug therapy; Humans; Oxaliplatin; Peripheral Nervous System Diseases; chemically induced; Pilot Projects; Prospective Studies; Quality of Life
UT PubMed:32168417
PM 32168417
DA 2020-03-14
ER

PT J
AU Ee, C
   Kay, S
   Reynolds, A
   Lovato, N
   Lacey, J
   Koczwara, B
AF Ee, Carolyn
   Kay, Shelley
   Reynolds, Amy
   Lovato, Nicole
   Lacey, Judith
   Koczwara, Bogda
TI Lifestyle and integrative oncology interventions for cancer-related fatigue and 
SO Maturitas
LA English
DT Review
DE Cancer survivors; Diet; Exercise; Fatigue; Integrative oncology; Sleep
AB Fatigue, insomnia and sleep disturbances are common after cancer diagnosis, and 
   have a negative impact on quality of life and function. This narrative review 
   synthesised evidence on lifestyle and integrative oncology interventions for 
   cancer-related fatigue, insomnia and sleep disturbances in cancer survivors. 
   There is strong evidence in support of aerobic and strength exercise for the 
   relief of cancer-related fatigue. Yoga, massage therapy, acupuncture, Tai Chi and 
   qigong can also be recommended for cancer-related fatigue. The evidence on yoga, 
   acupuncture and massage therapy for sleep disturbances in cancer is mixed, while 
   exercise appears to have a modest favourable effect. There is insufficient 
   evidence on nutrient supplements or dietary interventions for cancer-related 
   fatigue or insomnia and other sleep disturbances after cancer. Beyond alleviating 
   cancer-related fatigue and insomnia-related symptoms, integrative oncology and 
   lifestyle interventions have potential to effect multiple other benefits, such as 
   improvement in symptoms such as pain and menopausal symptoms. There is a need for 
   well-designed randomised controlled trials of interventions, particularly in the 
   areas of diet and nutrient supplements, and for implementation studies of 
   interventions already supported by evidence.
C1 NICM Health Research Institute, Western Sydney University, Locked Bag 1797, Penrith, NSW 2751, Australia
   Supportive Care and Integrative OncologyDepartment, Chris O'Brien Lifehouse, PO Box M33, Missenden Road, Camperdown, NSW2050, Australia
   Caring Futures Institute, Flinders University, GPO Box 2100,Adelaide 5001, South Australia, Australia
   Translational Health Institute,Western Sydney University, Locked Bag 1797, Penrith 2751, NSW, Australia.
   Supportive Care and Integrative Oncology Department, Chris O'Brien Lifehouse, PO Box M33, Missenden Road, Camperdown, NSW 2050, Australia. 
   Flinders Health and Medical Research Institute (Sleep Health), Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia
   AdelaideInstitute for Sleep Health, Flinders University, GPO Box 2100, Adelaide 5001,South Australia, Australia. 
   Flinders Health and Medical Research Institute (Sleep Health), Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia
   AdelaideInstitute for Sleep Health, Flinders University, GPO Box 2100, Adelaide 5001,South Australia, Australia. 
   NICM Health Research Institute, Western Sydney University, Locked Bag 1797, Penrith, NSW 2751, Australia
   Supportive Care and Integrative OncologyDepartment, Chris O'Brien Lifehouse, PO Box M33, Missenden Road, Camperdown, NSW2050, Australia
   School of Medicine, University of Sydney, NSW 2006, Australia.
   Flinders Health and Medical Research Institute (Sleep Health), Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia
   Departmentof Medical Oncology, Flinders Medical Centre, Flinders Drive, Bedford Park 5042,South Australia, Australia. 
EM bogda.koczwara@flinders.edu.au
NR 0
TC 0
SN 1873-411
EI 
J9 Maturitas
PD JUL 9
PY 2024
VL 187
IS 
BP 108056
EP 108056
DI 10.1016/j.maturitas.2024.108056 
PG 0
WC Humans; Fatigue; therapy; Neoplasms; complications; Integrative Oncology; methods; Life Style; Sleep Wake Disorders; therapy; Exercise; Cancer Survivors; Quality of Life; Sleep Initiation and Maintenance Disorders; therapy; Massage; methods; Yoga; Acupuncture Therapy; methods; Dietary Supplements; Qigong; Tai Ji
UT PubMed:38981156
PM 38981156
DA 2024-07-09
ER

PT J
AU Han, X
   Wang, L
   Shi, H
   Zheng, G
   He, J
   Wu, W
   Shi, J
   Wei, G
   Zheng, W
   Sun, J
   Huang, H
   Cai, Z
AF Han, Xiaoyan
   Wang, Lijuan
   Shi, Hongfei
   Zheng, Gaofeng
   He, Jingsong
   Wu, Wenjun
   Shi, Jimin
   Wei, Guoqing
   Zheng, Weiyan
   Sun, Jie
   Huang, He
   Cai, Zhen
TI Acupuncture combined with methylcobalamin for the treatment of 
SO BMC cancer
LA English
DT Journal Article
DE Acupuncture; CIPN; Methylcobalamin; Multiple myeloma
AB BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) seriously affects 
   the quality of life of patients with multiple myeloma (MM) as well as the 
   response rate to chemotherapy. Acupuncture has a potential role in the treatment 
   of CIPN, but at present there have been no randomized clinical research studies 
   to analyze the effectiveness of acupuncture for the treatment of CIPN, 
   particularly in MM patients. METHODS: The MM patients (104 individuals) who met 
   the inclusion criteria were randomly assigned into a solely methylcobalamin 
   therapy group (500 μg intramuscular methylcobalamin injections every other day 
   for 20 days; ten injections) followed by 2 months of 500 μg oral methylcobalamin 
   administration, three times per day) and an acupuncture combined with 
   methylcobalamin (Met + Acu) group (methylcobalamin used the same way as above 
   accompanied by three cycles of acupuncture). Of the patients, 98 out of 104 
   completed the treatment and follow-ups. There were 49 patients in each group. The 
   evaluating parameters included the visual analogue scale (VAS) pain score, 
   Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity 
   (Fact/GOG-Ntx) questionnaire scores, and electromyographic (EMG) nerve conduction 
   velocity (NCV) determinations. We evaluated the changes of the parameters in each 
   group before and after the therapies and made a comparison between the two 
   groups. RESULTS: After 84 days (three cycles) of therapy, the pain was 
   significantly alleviated in both groups, with a significantly higher decrease in 
   the acupuncture treated group (P < 0.01). The patients' daily activity evaluated 
   by Fact/GOG-Ntx questionnaires significantly improved in the Met + Acu group 
   (P < 0.001). The NCV in the Met + Acu group improved significantly while 
   amelioration in the control group was not observed. CONCLUSIONS: The present 
   study suggests that acupuncture combined with methylcobalamin in the treatment of 
   CIPN showed a better outcome than methylcobalamin administration alone. TRIAL 
   REGISTRATION: China Clinical Trials Register (registration no. 
   ChiCTR-INR-16009079 , registration date August 24, 2016).
C1 Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China.
   Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China.
   Present Address: Department of Hematology, Hematology Laboratory, Linyi People's 
   Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China.
   Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China.
   Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China.
   Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China.
   Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China.
   Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China.
   Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China.
   Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China.
   Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China.
   Multiple Myeloma Center, Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, ZhejiangUniversity, No. 79 Qingchun Road, Hangzhou, 310003, China. caiz@zju.edu.cn.
NR 0
TC 0
SN 1471-240
EI 
J9 BMC Cancer
PD JAN 11
PY 2017
VL 17
IS 1
BP 40
EP 40
DI 10.1186/s12885-016-3037-z 
PG 0
WC Acupuncture Therapy; Aged; Antineoplastic Combined Chemotherapy Protocols; adverse effects; China; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Multiple Myeloma; drug therapy; Neoplasm Staging; Peripheral Nervous System Diseases; chemically induced; Prognosis; Quality of Life; Surveys and Questionnaires; Survival Rate; Vitamin B 12; analogs & derivatives
UT PubMed:28068938
PM 28068938
DA 2017-01-11
ER

PT J
AU Towler, P
   Molassiotis, A
   Brearley, SG
AF Towler, P
   Molassiotis, A
   Brearley, S G
TI What is the evidence for the use of acupuncture as an intervention for symptom 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
AB PURPOSE: This study aims to systematically appraise the evidence for the use of 
   acupuncture for symptom management in cancer and supportive care and to identify 
   recommendations for clinical practice and future research. METHODS: A systematic 
   search was carried out to identify reviews of the use of acupuncture in cancer 
   supportive and palliative care, using MEDLINE, EMBASE, CINAHL, Web of Science, 
   Cochrane Library, British Nursing Index, Index to Theses, Dissertations and 
   Theses (via Proquest) and NHS evidence. Search terms included: acupuncture, 
   cancer and symptoms. Data were extracted for analysis. Reviews were assessed for 
   quality using a five-item checklist but were not excluded from the review on 
   grounds of quality, in order to include a comprehensive scope of the subject. 
   RESULTS: Seventeen reviews were included in the review. Evidence was found for 
   the use of acupuncture for treatment-related nausea and vomiting. Benefit was 
   reported for other cancer-related symptoms, including pain, fatigue, hot flushes, 
   xerostomia, dyspnoea and anxiety. Reviewers found a paucity of rigorous trials 
   and heterogeneity of populations, interventions, controls and outcome measures, 
   which challenge the process of systematic review and meta-analysis. CONCLUSION: 
   Acupuncture should be considered for symptom management where there are limited 
   treatment options, using current peer-reviewed guidelines and clinical reasoning. 
   Much of the primary research reported in reviews is innovative and indicates 
   potential benefit for people with cancer-related symptoms. The complexity of 
   acupuncture as an intervention needs to be acknowledged in future research 
   designs and when reviewing research findings. An iterative approach using 
   adequate interventions, appropriate outcome measures and adherence to reporting 
   standards is required to evaluate the efficacy of acupuncture in cancer 
   supportive and palliative care.
C1 University of Manchester, Manchester, UK.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD JUL 23
PY 2013
VL 21
IS 10
BP 2913
EP 23
DI 10.1007/s00520-013-1882-8 
PG -2890
WC Acupuncture Therapy; methods; Evidence-Based Medicine; Humans; Neoplasms; therapy; Palliative Care; methods
UT PubMed:23868190
PM 23868190
DA 2013-07-23
ER

PT J
AU Jin, M
   Xie, L
   Mao, N
   Wei, J
   Chen, J
   Chen, X
   Mao, H
AF Jin, Ming
   Xie, Lulu
   Mao, Ni
   Wei, Jianzi
   Chen, Junchao
   Chen, Xuefen
   Mao, Huijuan
TI The characteristics of registered acupuncture clinical trials enrolling cancer 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Review
DE Acupuncture; Cancer; Cancer-related symptoms; Clinical trial registration
AB PURPOSE: This study sought to explore and summarize the global state of 
   acupuncture clinical trials enrolling cancer patients included in international 
   registries to date. METHODS: All relevant trials evaluating acupuncture-related 
   interventions for the treatment of cancer that were registered in 16 trial 
   registries from January 1, 2001, through December 31, 2020, were identified. 
   Subsequent publications related to these trials were additionally retrieved from 
   the PubMed, Cochrane Library, Embase, CNKI (China National Knowledge 
   Infrastructure), VIP (China Science and Technology Journal Database), and Wanfang 
   databases. We compared information included in these registries regarding 
   completed trials with any associated publications, with a focus on study design, 
   sample size, and selective reporting, based on the registered protocol. RESULTS: 
   In total, 222 eligible trials across 19 countries were identified. These trials 
   included 17 specific cancer types and 32 symptoms. The five most common cancer 
   types were breast cancer, head and neck cancer, colorectal cancer, lung cancer, 
   and gastric cancer, accounting for almost half of all registered trials (48.2%). 
   The top five symptoms included in these trials were chemotherapy-induced 
   peripheral neuropathy (CIPN), cancer-related pain, cancer-related fatigue, 
   chemotherapy-induced nausea and vomiting (CINV), and gastrointestinal 
   dysfunction. The overall rate of article publication was low, with publications 
   being associated with just 33.3% of these registered trials. CONCLUSIONS: This 
   review is the first snapshot of the landscape of acupuncture clinical trials 
   registered in international trial registries, providing a methodological basis 
   for the management of common treatment- and disease-related side effects among 
   cancer patients undergoing acupuncture and offering useful information that will 
   guide future acupuncture-focused research.
C1 Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
   Institute of Disciplinary Science, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
   School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. chenxf915@163.com.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. maohuijuan1977@hotmail.com.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD SEP 2
PY 2022
VL 30
IS 12
BP 10461
EP 10470
DI 10.1007/s00520-022-07331-9 
PG 9
WC Female; Humans; Acupuncture; Acupuncture Therapy; methods; Antineoplastic Agents; Breast Neoplasms; Nausea; therapy; Clinical Trials as Topic
UT PubMed:36048280
PM 36048280
DA 2022-09-02
ER

PT J
AU Chen, H
   So, TH
   Cho, WC
   Qin, Z
   Ma, CH
   Li, SG
   Yang, Z
   Jiang, F
   Wu, J
   Zhang, ZJ
   Kong, FM
   Lao, L
AF Chen, Haiyong
   So, Tsz Him
   Cho, William Chi-Shing
   Qin, Zongshi
   Ma, Chun Ho
   Li, Shi Guang
   Yang, Zhenjiang
   Jiang, Fei
   Wu, Junmei
   Zhang, Zhang Jin
   Kong, Feng Ming
   Lao, Lixing
TI The Adjunctive Effect of Acupuncture for Advanced Cancer Patients in a 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; cancer related symptoms; palliative care; quality of life; randomized controlled trial
AB BACKGROUND: Cancer is the second leading cause of death before the age of 70. 
   Improved cancer survival has put increasing demands on cancer care. Palliative 
   care is the specialized multi-disciplinary care providing relief from the pain, 
   symptoms, and stress of serious illness. The study aims to evaluate the 
   adjunctive effect of acupuncture for advanced cancer patients in a collaborative 
   model of palliative care. METHODS/DESIGN: This is a single-blinded, randomized, 
   sham-controlled trial. One hundred twenty advanced cancer patients undergoing 
   palliative care will be randomized in a ratio of 2:1:1 to manual acupuncture plus 
   standard care group (ASC), sham acupuncture plus standard care group (SSC), and 
   standard care group (SC). Patients in ASC and SSC will receive 9 sessions of 
   acupuncture or sham acupuncture for 3 weeks, and will be followed up for 
   2 months. The primary measure is the change from baseline score of the Edmonton 
   Symptom Assessment System at 3 weeks. The secondary measures include the Brief 
   Fatigue Inventory, Hospital Anxiety and Depression Scale, Insomnia Severity 
   Index, Numeric Rating Scale, and European Organization for Research and Treatment 
   of Cancer Quality of Life 15 items Questionnaire for Palliative Care. DISCUSSION: 
   The finding of this trial will provide high-quality evidence on the adjunctive 
   effect of acupuncture to standard care on advanced cancer patients undergoing 
   palliative care. TRIAL REGISTRATION: Clinicaltrials.gov, NCT04398875 
   (https://www.clinicaltrials.gov/ct2/show/NCT04398875), Registered on 21 May 2020.
C1 The University of Hong Kong, Hong Kong, China.
   The University of Hong Kong, Hong Kong, China.
   Queen Elizabeth Hospital, Hong Kong, China.
   The University of Hong Kong, Hong Kong, China.
   The University of Hong Kong Clinical Centre for Teaching and Research in Chinese Medicine (Aberdeen), Hong Kong, China.
   Shen Zhen Hospital of Traditional Chinese Medicine, Shenzhen, China.
   Shen Zhen Hospital of Traditional Chinese Medicine, Shenzhen, China.
   University of California, San Francisco, CA, USA.
   The University of Hong Kong, Hong Kong, China.
   The University of Hong Kong, Hong Kong, China.
   Queen Elizabeth Hospital, Hong Kong, China.
   The University of Hong Kong, Hong Kong, China.
   Virginia University of Integrative Medicine, Fairfax, VA, USA.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD MAY 8
PY 2021
VL 20
IS 
BP 15347354211012749
EP 15347354211012749
DI 10.1177/15347354211012749 
PG 1
WC Acupuncture Therapy; Humans; Neoplasms; therapy; Palliative Care; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:33957783
PM 33957783
DA 2021-05-08
ER

PT J
AU Sui, M
   Lessans, S
   Yan, T
   Cao, D
   Lao, L
   Dorsey, SG
AF Sui, Minghong
   Lessans, Sherrie
   Yan, Tiebin
   Cao, Dongyuan
   Lao, Lixing
   Dorsey, Susag G
TI [Mechanism of electroacupuncture on "Zusanli (ST 36)" for chemotherapy-induced 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB OBJECTIVE: To observe the effects and duration of electroacupuncture on the 
   mechanical pain threshold induced by paclitaxel and explore its analgesic 
   mechanism. METHODS: Sixty-four C57BL/6J male mice were randomly divided into 4 
   groups, a normal+sham EA group, a normal+EA group, a medicine+sham EA(Med+ sham 
   EA) group, a medicine + EA (Med + EA) group, 16 cases in each group. The model of 
   chemotherapy-induced peripheral neuropathy was established with paclitaxel 
   intraperitoneal injection on the 1st, 3rd, 5th, 7th day in the Med + sham EA 
   group and the Med + EA group. EA of 30 min was used on bilateral "Zusanli (ST 
   36)" on the 9th, 11th, 13th, 16th, 18th, 20th, 23rd, 25th, 27th, 30th day in the 
   EA groups, 2 Hz/100 Hz and 1~ 1.5 mA. Acupuncture was applied on the same 
   acupoint at the same times in the sham EA groups. Mechanical pain thresholds were 
   tested by VonFrey before and after model establishment, namely on the 8th, 14th; 
   21st and, 28th day. The heart blood of 8 mice was drawn quickly to collect serum 
   in every group on the 31st day, and the contents of tumor necrosis factor α 
   (TNF-α), interleukin-1α (IL-1α), interleukin-1β (IL-1β) in proinflammatory 
   cytokine were examined by ELISA. Mechanical pain thresholds were tested by 
   VonFrey for the rest 8 mice of each group until there was no apparent difference 
   in the two paclitaxel groups once a week,namely on the 35th, 42nd, 49th day. 
   RESULTS: The pain thresholds of each group were not statistically different 
   before model establishment (P > 0.05). After model establishment (on the 8th 
   day), thresholds of the paclitaxel groups were lower than those of the normal 
   groups (all P < 0.05). After EA, the mechanical pain thresholds of the Med + EA 
   group were higher than those of the Med + sham EA group at all the time points, 
   and there was statistical difference on the 14th, 21st and 28th day (all P < 
   0.05). The analgesic effect was lasting to the 49th day. The contents of TNF-α, 
   IL-1α, IL-1β of the Med + EA group were decreased than those of the Med+sham EA 
   group in different degree, with statistical significance of IL-1α (P < 0.05). 
   CONCLUSION: EA can effectively treat paclitaxel-induced peripheral neuropathy,and 
   the analgesic mechanism is probably related to decreasing the proinflammatory 
   cytokine.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD AUG 12
PY 2016
VL 36
IS 5
BP 512
EP 6
DI 
PG -506
WC Acupuncture Points; Animals; Antineoplastic Agents; administration & dosage; Electroacupuncture; Humans; Interleukin-1beta; genetics; Male; Mice; Mice, Inbred C57BL; Neoplasms; drug therapy; Peripheral Nervous System Diseases; etiology; Tumor Necrosis Factor-alpha; genetics
UT PubMed:27509614
PM 27509614
DA 2016-08-12
ER

PT J
AU Lu, C
   Feng, X
   Shen, Q
   Li, G
   Wu, T
   Li, X
   Shao, X
   Wang, P
   Li, R
   Deng, Y
   Chen, W
AF Lu, Chao
   Feng, Xukang
   Shen, Qiongying
   Li, Guangliang
   Wu, Taoping
   Li, Xiaoyu
   Shao, Xiying
   Wang, Peipei
   Li, Rongrong
   Deng, Yaping
   Chen, Weiji
TI [Electroacupuncture with different frequencies for paclitaxel-induced peripheral 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE breast cancer; chemotherapy-induced peripheral neuropathy (CIPN); electroacupuncture; paclitaxel; randomized controlled trial (RCT)
AB OBJECTIVE: To observe the clinical efficacy of electroacupuncture (EA) at 
   frequencies of 2 Hz, 100 Hz, and 2 Hz/100 Hz for chemotherapy-induced peripheral 
   neuropathy (CIPN). METHODS: One hundred and sixty female breast cancer patients 
   with CIPN induced by paclitaxel were randomly divided into a 2 Hz EA group (40 
   cases, 1 case dropped out), a 100 Hz EA group (40 cases, 2 cases dropped out), a 
   2 Hz/100 Hz EA group (40 cases, 3 cases dropped out), and a medication group (40 
   cases, 2 cases dropped out). The three EA groups received acupuncture at 
   bilateral Quchi (LI 11), Waiguan (TE 5), Hegu (LI 4), Zusanli (ST 36), and 
   Yanglingquan (GB 34). Electrodes of the HANS-200E acupoint nerve stimulator were 
   connected to the same side Hegu (LI 4) and Waiguan (TE 5), and Zusanli (ST 36) 
   and Sanyinjiao (SP 6), with EA stimulation frequencies of 2 Hz, 100 Hz, and 2 
   Hz/100 Hz, respectively. Each session lasted 30 min, once every other day, three 
   times a week. The medication group received oral mecobalamin tablets, 0.5 mg per 
   dose, three times a day. All groups were treated for four weeks. The functional 
   assessment of cancer therapy/gynaecologic oncology group-neurotoxicity 
   (FACT/GOG-Ntx), peripheral neurotoxicity grading based on the National Cancer 
   Institute-common terminology criteria for adverse events Version 5.0 (NCI-CTCAE 
   V5.0), and peripheral neuropathy pain visual analogue scale (VAS) scores were 
   observed before and after treatment, and at follow-up after 4 weeks of treatment 
   completion, and clinical efficacy was evaluated after theatment. RESULTS: 
   Compared before treatment, FACT/GOG-Ntx scores in all groups were decreased after 
   treatment and during follow-up (P<0.01). The score reduction between before and 
   after treatment in the three EA groups was greater than the medication group 
   (P<0.01, P<0.05), with the 2 Hz and 2 Hz/100 Hz EA groups showing a greater 
   reduction than the 100 Hz EA group (P<0.05). The reduction of FACT/GOG-Ntx score 
   between before treatment and follow-up in the 2 Hz and 2 Hz/100 Hz EA groups was 
   greater than the medication group (P<0.01). Peripheral neurotoxicity grading in 
   the three EA groups were improved after treatment (P<0.01). Compared before 
   treatment, the peripheral neurotoxicity grading in the 2 Hz and 2 Hz/100 Hz EA 
   groups was improved at follow-up (P<0.01, P<0.05). The VAS scores for peripheral 
   neuropathy pain in the three EA groups were decreased after treatment (P<0.01, 
   P<0.05). At follow-up, VAS scores in the 2 Hz, 2 Hz/100 Hz, and medication groups 
   were decreased (P<0.01, P<0.05), with a greater reduction in the 2 Hz/100 Hz EA 
   group than the medication group after treatment and follow-up (P<0.01, P<0.05). 
   The overall effective rates for the 2 Hz, 100 Hz, 2 Hz/100 Hz, and medication 
   groups were 79.5% (31/39), 68.4% (26/38), 81.1% (30/37), and 47.4% (18/38), 
   respectively, with the 2 Hz and 2 Hz/100 Hz groups showing higher effective rates 
   than the medication group (P<0.05). CONCLUSION: EA is effective in treating 
   paclitaxel-induced CIPN. While there is no overall difference in efficacy among 
   the different frequencies, 2 Hz and 2 Hz/100 Hz EA showing potential advantages. 
   For patients with concurrent peripheral neuropathy pain, 2 Hz/100 Hz 
   electroacupuncture is recommended.
C1 Department of TCM, Zhejiang Cancer Hospital, Hangzhou 310022, China.
   Third Clinical Medical College of Zhejiang Chinese Medical University.
   Third Clinical Medical College of Zhejiang Chinese Medical University.
   Department of Breast Oncology, Zhejiang Cancer Hospital.
   Third Clinical Medical College of Zhejiang Chinese Medical University.
   Third Clinical Medical College of Zhejiang Chinese Medical University.
   Department of Breast Oncology, Zhejiang Cancer Hospital.
   Department of TCM, Zhejiang Cancer Hospital, Hangzhou 310022, China.
   Department of Acupuncture and Moxibustion, Third Affiliated Hospital of Zhejiang Chinese Medical University/Zhejiang Zhongshan Hospital.
   Department of Breast Oncology, Zhejiang Cancer Hospital.
   Department of Acupuncture and Moxibustion, Third Affiliated Hospital of Zhejiang Chinese Medical University/Zhejiang Zhongshan Hospital.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD OCT 15
PY 2024
VL 44
IS 10
BP 1139
EP 45
DI 10.13703/j.0255-2930.20240123-0001 
PG -1094
WC Humans; Electroacupuncture; Female; Peripheral Nervous System Diseases; therapy; Middle Aged; Paclitaxel; adverse effects; Adult; Aged; Breast Neoplasms; therapy; Acupuncture Points; Treatment Outcome
UT PubMed:39401811
PM 39401811
DA 2024-10-15
ER

PT J
AU Zhou, M
   Li, Y
   Han, X
   Xing, Q
   Wang, Y
   Dong, X
   Chang, J
AF Zhou, Mintao
   Li, Yu
   Han, Xuechang
   Xing, Qunzhi
   Wang, Yiyao
   Dong, Xu
   Chang, Junxiao
TI [Clinical research of electroacupuncture on the analgesic effect of thoracic 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE Neimadian; Point, PC 6 (Neiguan); analgesia; electroacupuncture; thoracic surgery
AB OBJECTIVE: To discuss the clinical therapeutic effects of electroacupuncture at 
   Neimadian (Extra) and Neiguan (PC 6) on the analgesic effect of thoracic 
   perioperative stage and its effect mechanism. METHODS: Sixty cases of esophageal 
   cancer with elective radical resection under general anesthesia were divided into 
   an observation group and a control group according to the operation sequence, 30 
   cases in each one. In the control group, the general anesthesia was simply 
   applied and sufentanil was administered for patient controlled intravenous 
   analgesia (PCIA) after operation. In the observation group, on the basis of the 
   scheme as the control group, the electroacupuncture was used at Neimadian (Extra) 
   and Neiguan (PC 6) 30 min before anesthesia induction and after operation, with 
   continuous wave, tolerable intensity, lasting for 30 min. Separately, before 
   acupuncture (T1) and 2h (T2), 12h (T3), 24h (T4) and 48h (T5) after operation, 
   the plasma β-endorphin (β-EP), 5-hydroxytryptamine (5-HT) and prostaglandin E(2) 
   (PGE(2)) were determined. During operation, under the same state (from 50 to 60) 
   of bispectrum of EEG (BIS), the intraoperative anesthetic dose was recorded. 
   Using visual analogue scale (VAS), the pain degree was evaluated at T2, T3, T4 
   and T5 separately and the grade assessment of the therapeutic effects and safety 
   were recorded at each time point. RESULTS: ①The total dosage of sufentanil in the 
   observation group was less than that in the control group[(1.83±0.56) mg vs 
   (2.54±0.62) mg, P<0.05]. ②VAS scores at T2, T3 and T4 in the patients of the 
   observation group were all lower than those in the control group (all P<0.05). 
   ③The levels of plasma β-EP at T3, T4 and T5 in the observation group were 
   increased significantly as compared with those in the control group (all P<0.05) 
   and the levels of plasma 5-HT and PGE(2) at T2, T3 and T4 were reduced 
   significantly as compared with those in the control group (all P<0.05). ④ The 
   excellent analgesia rates 2h、12h and 24h after operation in the observation group 
   were better than those in the control group (all P<0.05). ⑤The rate of the A 
   grade safety in the observation group was higher than that in the control group 
   (P<0.05). CONCLUSIONS: Electroacupuncture at Neimadian (Extra) and Neiguan (PC 6) 
   provides the safe and effective postoperative anesthesia of thoracic surgery and 
   reduces the dosage of analgesics during the operation, which is possibly related 
   to the increase of endogenous β-EP and the inhibition on the release of 5-HT and 
   PGE(2).
C1 Clinical Medical School of Henan University of Science and Technology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang471003, China.
   Clinical Medical School of Henan University of Science and Technology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang471003, China.
   Clinical Medical School of Henan University of Science and Technology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang471003, China.
   Clinical Medical School of Henan University of Science and Technology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang471003, China.
   Clinical Medical School of Henan University of Science and Technology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang471003, China.
   Clinical Medical School of Henan University of Science and Technology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang471003, China.
   Clinical Medical School of Henan University of Science and Technology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang471003, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD DEC 13
PY 2017
VL 37
IS 7
BP 705
EP 709
DI 10.13703/j.0255-2930.2017.07.006 
PG 4
WC Acupuncture Analgesia; Acupuncture Points; Anesthesia, General; Anesthetics, Intravenous; administration & dosage; Biomedical Research; Case-Control Studies; Dinoprostone; blood; Electroacupuncture; methods; Esophageal Neoplasms; surgery; Humans; Pain Management; Pain Measurement; Serotonin; blood; Sufentanil; administration & dosage; beta-Endorphin; blood
UT PubMed:29231542
PM 29231542
DA 2017-12-13
ER

PT J
AU Deng, G
   Giralt, S
   Chung, DJ
   Landau, H
   Siman, J
   Search, B
   Coleton, M
   Vertosick, E
   Shapiro, N
   Chien, C
   Wang, XS
   Cassileth, B
   Mao, JJ
AF Deng, Gary
   Giralt, Sergio
   Chung, David J
   Landau, Heather
   Siman, Jonathan
   Search, Benjamin
   Coleton, Marci
   Vertosick, Emily
   Shapiro, Nathan
   Chien, Christine
   Wang, Xin S
   Cassileth, Barrie
   Mao, Jun J
TI Acupuncture for reduction of symptom burden in multiple myeloma patients 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture; Complementary therapies; Hematopoietic stem cell transplantation; Integrative medicine; Multiple myeloma; Symptom management
AB PURPOSE: Hematopoietic stem cell transplantation (HCT) is potentially curative 
   for a number of hematologic malignancies, but is associated with high symptom 
   burden. We conducted a randomized sham-controlled trial (RCT) to evaluate 
   efficacy and safety of acupuncture as an integrative treatment for managing 
   common symptoms during HCT. METHODS: Adult patients with multiple myeloma 
   undergoing high-dose melphalan followed by autologous HCT (AHCT) were randomized 
   to receive either true or sham acupuncture once daily for 5 days starting the day 
   after chemotherapy. Patients and clinical evaluators, but not acupuncturists, 
   were blinded to group assignment. Symptom burden, the primary outcome was 
   assessed with the MD Anderson Symptom Inventory (MDASI) at baseline, during 
   transplantation, and at 15 and 30 days post transplantation. RESULTS: Among 60 
   participants, true acupuncture produced nonsignificant reductions in overall 
   MDASI core symptom scores and symptom interference scores during transplantation 
   (P = .4 and .3, respectively), at 15 days (P = .10 and .3), and at 30 days 
   posttransplantation (P = .2 and .4) relative to sham. However, true acupuncture 
   was significantly more efficacious in reducing nausea, lack of appetite, and 
   drowsiness at 15 days (P = .042, .025, and .010, respectively). Patients 
   receiving sham acupuncture were more likely to increase pain medication use 
   posttransplantation (odds ratio 5.31, P = .017). CONCLUSIONS: Acupuncture was 
   well tolerated with few attributable adverse events. True acupuncture may prevent 
   escalation of symptoms including nausea, lack of appetite, and drowsiness 
   experienced by patients undergoing AHCT, and reduce the use of pain medications. 
   These findings need to be confirmed in a future definitive study. TRIAL 
   REGISTRATION: NCT01811862.
C1 Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA. dengg@mskcc.org.
   Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
   Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
   Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
   Health Outcomes Research Group, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Health Outcomes Research Group, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Health Outcomes Research Group, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
   Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
NR 0
TC 0
SN 1433-733
EI 0941-435
J9 Support Care Cancer
PD SEP 19
PY 2017
VL 26
IS 2
BP 657
EP 665
DI 10.1007/s00520-017-3881-7 
PG 8
WC Acupuncture Therapy; methods; Female; Hematopoietic Stem Cell Transplantation; methods; Humans; Male; Multiple Myeloma; therapy; Prospective Studies; Transplantation, Autologous; methods
UT PubMed:28920142
PM 28920142
DA 2017-09-19
ER

PT J
AU Sasaki, Y
   Cheon, C
   Motoo, Y
   Jang, S
   Park, S
   Ko, SG
   Jang, BH
   Hwang, DS
AF Sasaki, Yui
   Cheon, Chunhoo
   Motoo, Yoshiharu
   Jang, Soobin
   Park, Sunju
   Ko, Seong-Gyu
   Jang, Bo-Hyoung
   Hwang, Deok-Sang
TI [Complementary and Alternative Medicine for Breast Cancer Patients: An Overview 
SO Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
LA jpn
DT Journal Article
DE breast cancer; complementary and alternative medicine; overview; systematic review
AB The application of systematic review (SR) has been increased rapidly in the field 
   of cancer treatment. Complementary and alternative medicine (CAM) for cancer is 
   no exception. The aim of this review is to evaluate and summarize systematic 
   reviews on the CAM use in breast cancer patients. Search sources were Centre for 
   Reviews and Dissemination (CRD), Cochrane Database of Systematic Reviews (CDSR), 
   and PubMed. In addition, we assessed the quality of SR with the Assessing the 
   Methodological Quality of Systematic Reviews (AMSTAR). This review did not 
   consider control groups and outcomes. Thirty-four SRs met a set of criteria. 
   According to interventions, there were twenty SRs which included yoga, 
   acupuncture, and herbal medicines. Meta-analysis of 19 out of 34 reviews showed 
   the followings: (1) acupuncture had a beneficial effect on the frequency of hot 
   flushes, (2) yoga had a beneficial effect on depression and health-related QOL, 
   (3) mindfulness-based stress reduction (MBSR) had a beneficial effect on anxiety 
   and depression, (4) combination of herbal medicine and chemotherapy 
   synergistically improved clinical outcomes, (5) acupuncture did not show 
   significant effect on the severity of hot flushes and cancer-related pain, (6) 
   yoga was unable to be confirmed as having an effect on cancer-related pain and 
   physical well-being. Given the results of AMSTAR, 9 out of 34 reviews were of 
   high quality and 3 reviews were deemed to be of low quality. In conclusion, since 
   most SRs were at moderate or high quality levels, CAM could be helpful for 
   treating specific symptoms related to breast cancer.
C1 Department of Applied Korean Medicine, Graduate School, Kyung Hee University.
   Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University.
   Department of Medical Oncology, Kanazawa Medical University.
   Clinical Medicine Division, Korea Institute of Oriental Medicine.
   Department of Preventive Medicine, College of Korean Medicine, Daejeon University.
   Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University.
   Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University.
   Department of Korean Gynecology, College of Korean Medicine, Kyung Hee University.
NR 0
TC 0
SN 1347-523
EI 
J9 Yakugaku Zasshi
PD JUL 2
PY 2019
VL 139
IS 7
BP 1027
EP 1046
DI 10.1248/yakushi.18-00215 
PG 19
WC Acupuncture Therapy; Anxiety; Breast Neoplasms; psychology; Complementary Therapies; Databases, Bibliographic; Depression; Female; Herbal Medicine; Humans; Mindfulness; Palliative Care; Quality of Life; Yoga
UT PubMed:31257250
PM 31257250
DA 2019-07-02
ER

PT J
AU Ogawa-Ochiai, K
   Yoshimura, K
   Takebe, T
   Iwahashi, M
   Shirai, A
   Tsuda, M
   Ogawa, M
   Ishikawa, H
AF Ogawa-Ochiai, Keiko
   Yoshimura, Kenichi
   Takebe, Takae
   Iwahashi, Mako
   Shirai, Akiko
   Tsuda, Masaki
   Ogawa, Masao
   Ishikawa, Hideki
TI The effect of contact needle therapy on fatigue in patients with cancer in 
SO Medicine
LA English
DT Journal Article
AB INTRODUCTION: Almost all patients with end-of-life cancer experience 
   cancer-related fatigue; however, there are only a few known effective coping 
   methods. OBJECTIVES: We will conduct a prospective, multi-center, single-blinded 
   randomized controlled study to evaluate the efficacy of acupuncture for 
   cancer-related fatigue in patients with end-of-life cancer. METHODS: We will 
   enroll 120 patients with cancer hospitalized in a palliative care unit or 
   receiving consultation from a palliative care team in four hospitals. We will add 
   acupuncture treatment; specifically, contact needle therapy (CNT), consisting of 
   an intervention per week period to the usual care. The primary outcome measure 
   will be the Cancer Fatigue Scale (CFS) score while the secondary outcome measures 
   will be the Numerical Rating Scale (NRS) score for fatigue, pain, and salivary 
   amylase levels. CONCLUSION: We will evaluate the possibility of using acupuncture 
   therapy, that is, CNT, in relieving fatigue sensation in patients with advanced 
   cancer. TRIAL REGISTRATION: UMIN000028304, registered on July 21st, 2017; 
   https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000032401.
C1 Department of Japanese Traditional (Kampo) Medicine, Kanazawa University Hospital, Ishikawa.
   Center for Integrated Medical Research, Hiroshima University Hospital, Hiroshima University, Hiroshima.
   Innovative Clinical Research Center, Kanazawa University Hospital, Ishikawa.
   Mukeido Clinic of Acupuncture, Toyama.
   Department of Japanese Traditional (Kampo) Medicine, Kanazawa University Hospital, Ishikawa.
   Department of Japanese Traditional (Kampo) Medicine, Kanazawa University Hospital, Ishikawa.
   Mukeido Clinic of Acupuncture, Toyama.
   Department of Anesthesiology, Kanazawa University Hospital, Ishikawa.
   Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Osaka, Japan.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD NOV 7
PY 2019
VL 98
IS 44
BP e17809
EP e17809
DI 10.1097/MD.0000000000017809 
PG 1
WC Adult; Humans; Acupuncture Therapy; methods; Fatigue; etiology; Medicine, Kampo; Neoplasms; complications; Palliative Care; Prospective Studies; Randomized Controlled Trials as Topic; Single-Blind Method; Terminal Care; Multicenter Studies as Topic
UT PubMed:31689865
PM 31689865
DA 2019-11-07
ER

PT J
AU Ouyang, BS
   Gao, J
   Che, JL
   Zhang, Y
   Li, J
   Yang, HZ
   Hu, TY
   Yang, M
   Wu, YJ
   Ji, LL
AF Ouyang, Ba-Si
   Gao, Jie
   Che, Jian-Li
   Zhang, Yin
   Li, Jun
   Yang, Hai-Zhou
   Hu, Tian-Yan
   Yang, Man
   Wu, Yuan-Jian
   Ji, Ling-Ling
TI Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial 
SO Chinese journal of integrative medicine
LA English
DT Journal Article
AB OBJECTIVE: To observe the effect of electro-acupuncture (EA) on tumor necrosis 
   factor-α (TNF-α) and vascular endothelial growth factor (VEGF) in peripheral 
   blood and joint synovia in patients with rheumatoid arthritis (RA) to verify the 
   clinical efficacy of EA. METHODS: Adopting randomized controlled principle, the 
   63 RA patients enrolled were assigned to two groups, the 32 patients in the EA 
   group were treated with EA, and the 31 patients in the simple needling (SN) group 
   treated with simple needling. According to the integral-local combining method, 
   the acupoints were selected mainly from yang-meridian and local Ashi points 
   (pain-point). EA or SN was applied every other day, 10 times as a course, and 
   each patient received a total of 3 courses of treatment. RESULTS: Blood and 
   synovial levels of TNF-α and VEGF were reduced significantly after treatment in 
   both groups. The lowering (absolute value and difference value) of TNF-α as well 
   as the absolute value of VEGF, either in blood or in synovia, were similar in the 
   two groups (P>0.05); but the lowering of VEGF after treatment was more 
   significant in the EA group than that in the SN group (P<0.05). CONCLUSION: EA 
   could effectively lower the contents of TNF-α and VEGF in peripheral blood and 
   joint synovia to improve the internal environment for genesis and development of 
   RA, so as to enhance the clinical therapeutic effectiveness.
C1 Suzhou Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu Province 215003, China. oybasi@163.com
NR 0
TC 0
SN 1993-040
EI 
J9 Chin J Integr Med
PD JUL 5
PY 2011
VL 17
IS 7
BP 505
EP 9
DI 10.1007/s11655-011-0783-2 
PG -496
WC Adolescent; Adult; Aged; Arthritis, Rheumatoid; blood; Electroacupuncture; adverse effects; Female; Humans; Joints; pathology; Male; Synovial Fluid; metabolism; Treatment Outcome; Tumor Necrosis Factor-alpha; blood; Vascular Endothelial Growth Factor A; blood; Young Adult
UT PubMed:21725875
PM 21725875
DA 2011-07-05
ER

PT J
AU Cassileth, BR
   Van, Zee KJ
   Yeung, KS
   Coleton, MI
   Cohen, S
   Chan, YH
   Vickers, AJ
   Sjoberg, DD
   Hudis, CA
AF Cassileth, Barrie R
   Van Zee, Kimberly J
   Yeung, K Simon
   Coleton, Marci I
   Cohen, Sara
   Chan, Yi H
   Vickers, Andrew J
   Sjoberg, Daniel D
   Hudis, Clifford A
TI Acupuncture in the treatment of upper-limb lymphedema: results of a pilot study.
SO Cancer
LA English
DT Journal Article
AB BACKGROUND: Current treatments for lymphedema after breast cancer treatment are 
   expensive and require ongoing intervention. Clinical experience and our 
   preliminary published results suggest that acupuncture is safe and potentially 
   useful. This study evaluates the safety and potential efficacy of acupuncture on 
   upper-limb circumference in women with lymphedema. METHODS: Women with a clinical 
   diagnosis of breast cancer-related lymphedema (BCRL) for 0.5-5 years and with 
   affected arm circumference ≥2 cm larger than unaffected arm received acupuncture 
   treatment twice weekly for 4 weeks. Affected and unaffected arm circumferences 
   were measured before and after each acupuncture treatment. Response, defined as 
   ≥30% reduction in circumference difference between affected/unaffected arms, was 
   assessed. Monthly follow-up calls for 6 months thereafter were made to document 
   any complications and self-reported lymphedema status. RESULTS: Among 37 enrolled 
   patients, 33 were evaluated; 4 discontinued due to time constraints. Mean 
   reduction in arm circumference difference was 0.90 cm (95% CI, 0.72-1.07; P < 
   .0005). Eleven patients (33%) exhibited a reduction of ≥30% after acupuncture 
   treatment. Seventy-six percent of patients received all treatments; 21% missed 1 
   treatment, and another patient missed 2 treatments. During the treatment period, 
   14 of the 33 patients reported minor complaints, including mild local bruising or 
   pain/tingling. There were no serious adverse events and no infections or severe 
   exacerbations after 255 treatment sessions and 6 months of follow-up interviews. 
   CONCLUSIONS: Acupuncture for BCRL appears safe and may reduce arm circumference. 
   Although these results await confirmation in a randomized trial, acupuncture can 
   be considered for women with no other options for sustained arm circumference 
   reduction.
C1 Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. Cassileth@mskcc.org
NR 0
TC 0
SN 1097-014
EI 0008-543
J9 Cancer
PD APR 12
PY 2013
VL 119
IS 13
BP 2455
EP 61
DI 10.1002/cncr.28093 
PG -2394
WC Acupuncture Therapy; adverse effects; Adult; Aged; Breast Neoplasms; therapy; Female; Follow-Up Studies; Humans; Lymphedema; etiology; Middle Aged; Patient Safety; Pilot Projects; Research Design; Surveys and Questionnaires; Treatment Outcome; Upper Extremity
UT PubMed:23576267
PM 23576267
DA 2013-04-12
ER

PT J
AU Li, X
   Lampson, K
   Ahles, TA
   Root, JC
   Li, QS
   Li, Y
   Ahsan, A
   Mao, JJ
   Liou, KT
AF Li, Xiaotong
   Lampson, Kaitlin
   Ahles, Tim A
   Root, James C
   Li, Q Susan
   Li, Yuelin
   Ahsan, Anam
   Mao, Jun J
   Liou, Kevin T
TI Feasibility and Preliminary Effects of Acupuncture for Cognitive Dysfunction in 
SO Current oncology (Toronto, Ont.)
LA English
DT Journal Article
DE acupuncture; cancer survivorship; cognitive dysfunction; feasibility; pilot study
AB (1) Background: This pilot study evaluates the feasibility and preliminary 
   effects of acupuncture for cancer-related cognitive dysfunction (CRCD) in cancer 
   survivors. (2) Methods: A randomized trial comparing real acupuncture (RA) to 
   sham acupuncture (SA) and waitlist control (WLC) among cancer survivors reporting 
   cognitive difficulties. Interventions were delivered weekly over 10 weeks. 
   Feasibility was evaluated by recruitment, treatment adherence, and assessment 
   completion. Subjective CRCD was assessed by the Functional Assessment of Cancer 
   Therapy-Cognitive Function-Perceived Cognitive Impairment subscale (FACT-Cog PCI) 
   and objective CRCD was assessed by the Hopkins Verbal Learning Test-Revised 
   (HVLT-R). (3) Results: 32 participants (57.1% of eligible patients) were 
   enrolled. All participants in acupuncture groups completed ≥8 of 10 treatments. 
   Assessment completion rate was 100% for all participants. From baseline to week 
   10, the RA group (n = 19) reported a clinically meaningful 17.3-point increase in 
   FACT-Cog PCI (95% confidence interval [CI] 12.5 to 22.1), compared to 9.7 points 
   (95% CI 2.8 to 16.7) in the SA group (n = 9), and 6.8 points (95% CI -3.7 to 
   17.2) in the WLC group (n = 4). In the subgroup analysis among patients with a 
   below-average baseline HVLT-R (T-score < 50), the RA group (n = 8) increased 
   FACT-Cog PCI scores by 20.4 (95% CI 13.6 to 27.3), compared to 11.1 points (95% 
   CI 0.6 to 21.5) in the SA group (n = 5). The improvements from RA persisted 
   through week 16 in both the total sample and the sub-group. Eleven mild adverse 
   events were reported, with pain and bleeding at the needling sites being the most 
   common. (4) Conclusions: The findings support the feasibility and safety of 
   conducting a randomized, placebo-controlled trial to evaluate acupuncture for 
   cognitive dysfunction in cancer survivors.
C1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer 
   Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
NR 0
TC 0
SN 1718-772
EI 1198-005
J9 Curr Oncol
PD JAN 24
PY 2025
VL 32
IS 1
BP 
EP 
DI 10.3390/curroncol32010027 
PG 0
WC Humans; Acupuncture Therapy; methods; Pilot Projects; Male; Female; Cancer Survivors; psychology; Cognitive Dysfunction; therapy; Middle Aged; Feasibility Studies; Aged; Neoplasms; complications; Adult
UT PubMed:39851943
PM 39851943
DA 2025-01-24
ER

PT J
AU Levy, Yurkovski I
   Andreazzoli, F
   Ben-Arye, E
   Attias, S
   Tadmor, T
AF Levy Yurkovski, Ilana
   Andreazzoli, Francesca
   Ben-Arye, Eran
   Attias, Samuel
   Tadmor, Tamar
TI Integrative Approaches in the Treatment of Patients Affected by Lymphoma.
SO Current oncology reports
LA English
DT Review
DE Complementary medicine; Haemato-oncology; Integrative medicine; Lymphoma
AB PURPOSE OF REVIEW: Lymphoma is the most frequent hematological malignancy with 
   wide disease spectrum of watchful waiting period, active treatment, survivorship, 
   and palliative care. All these steps impose unmet needs in terms of prevention, 
   symptom alleviation, or prognosis. Complementary and integrative medicine (CIM) 
   is widely used by patients with lymphoma to cope with such issues. Here, we 
   describe the different CIM modalities that may be effective and safe for the 
   management of patients with lymphoma. RECENT FINDINGS: Low inflammatory diet and 
   ginseng seem effective for lymphoma prevention. Pain and neuropathy may be 
   improved using acupuncture, touch therapy and specific dietary supplements. 
   Nausea/vomiting, fatigue, and insomnia may be relieved by acupuncture, mind-body, 
   touch therapy, and certain dietary supplements. Vitamin D, curcumin, and some 
   traditional medicine herbs may positively impact lymphoma prognosis. Finally, 
   safety issues should be considered especially for the concomitant use of dietary 
   supplements and lymphoma-directed therapies. CIM may be beneficial along the 
   continuum of lymphoma management although safety concerns should be considered 
   when used concomitantly with conventional therapy.
C1 Hematology Unit, Bnai Zion Medical Center, Golomb 47, 33394, Haifa, Israel. ilana.e.levy@gmail.com.
   Complementary Medicine Service, Bnai Zion Medical Center, Haifa, Israel. 
   Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, Israel. ilana.e.levy@gmail.com.
   Department of Hematology, Versilia's Hospital, Camaiore, Italy.
   Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, Israel.
   Integrative Oncology Program, The Oncology Service, Lin, Carmel & Zebulun Medical 
   Complementary Medicine Service, Bnai Zion Medical Center, Haifa, Israel.
   Hematology Unit, Bnai Zion Medical Center, Golomb 47, 33394, Haifa, Israel.
   Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, 
NR 0
TC 0
SN 1534-626
EI 
J9 Curr Oncol Rep
PD DEC 7
PY 2023
VL 25
IS 12
BP 1523
EP 1534
DI 10.1007/s11912-023-01476-4 
PG 11
WC Humans; Complementary Therapies; Acupuncture Therapy; Lymphoma; therapy; Diet; Nausea; Integrative Medicine
UT PubMed:38060095
PM 38060095
DA 2023-12-07
ER

PT J
AU Donald, GK
   Tobin, I
   Stringer, J
AF Donald, Graeme K
   Tobin, Irene
   Stringer, Jacqui
TI Evaluation of acupuncture in the management of chemotherapy-induced peripheral 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
AB AIM: To clinically evaluate the effectiveness of acupuncture when used in the 
   management of chemotherapy-induced peripheral neuropathy (PN). BACKGROUND: During 
   cancer treatment, certain chemotherapies can cause varying degrees of PN. 
   Patients' quality of life can be seriously impaired through loss of sensation, 
   pain or mobility problems. Conventional medications routinely used to manage 
   neuropathic symptoms have poor side-effect profiles and there is little or no 
   evidence justifying their use to treat chemotherapy-related neurotoxicities. 
   There are studies suggesting that acupuncture may be an effective therapy in 
   treating PN across a number of different aetiologies. Design A retrospective 
   service evaluation. METHOD: Patients (n=18) were referred for acupuncture by the 
   medical staff and/ornurse specialists or they self-referred for treatment. A 
   course of six weekly acupuncture sessions was offered to them, and their details 
   were recorded on an evaluation form prior to session one. Points were selected by 
   acupuncturists, based on patient presentation, and needles remained in situ for 
   30-45 min. Treatments took place in outpatient clinics, chemotherapy day case 
   ward or a drop-in clinic based in a physiotherapy gym. The evaluation form was 
   completed at the end of session 6 by a therapist who had not been involved in 
   patient care. RESULTS: 82% (n=14) of patients reported an improvement in symptoms 
   following their course of acupuncture; one patient with advanced disease died 
   during the 6 weeks. Some patients derived additional benefits from the treatment 
   including a reduction in analgesic use and improved sleeping patterns. The most 
   common acupoints used were SP6 (n=18), ST36 (n=18) and LV3 (n=14). CONCLUSION: 
   Although these results are encouraging, they are uncontrolled. They suggest that 
   acupuncture could be an option for these patients and controlled trials using 
   validated patient-reported outcome measures are justified.
C1 Complementary Therapy Service, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK. graeme.donald@christie.nhs.uk
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD AUG 31
PY 2011
VL 29
IS 3
BP 230
EP 3
DI 10.1136/acupmed.2011.010025 
PG -227
WC Acupuncture Therapy; Adult; Aged; Antineoplastic Agents; adverse effects; Female; Humans; Male; Middle Aged; Neoplasms; complications; Peripheral Nervous System Diseases; etiology
UT PubMed:21875929
PM 21875929
DA 2011-08-31
ER

PT J
AU Ben-Arye, E
   Hirsh, I
   Segev, Y
   Grach, M
   Master, V
   Eden, A
   Samuels, N
   Stein, N
   Gressel, O
   Ostrovsky, L
   Galil, G
   Schmidt, M
   Schiff, E
   Lavie, O
AF Ben-Arye, Eran
   Hirsh, Irena
   Segev, Yakir
   Grach, Michael
   Master, Viraj
   Eden, Arie
   Samuels, Noah
   Stein, Nili
   Gressel, Orit
   Ostrovsky, Ludmila
   Galil, Galit
   Schmidt, Meirav
   Schiff, Elad
   Lavie, Ofer
TI A randomized-controlled trial assessing the effect of intraoperative acupuncture 
SO Journal of cancer research and clinical oncology
LA English
DT Journal Article
DE Acupuncture; Gynecological oncology; Integrative medicine; Integrative oncology; Intraoperative; Pain
AB CONTEXT AND OBJECTIVES: The present study examined the impact of intraoperative 
   acupuncture on anesthesia-related parameters in patients undergoing gynecological 
   oncology surgery. METHODS: Participants underwent preoperative integrative 
   oncology (IO) touch/relaxation treatments, followed by intraoperative acupuncture 
   (Group A); preoperative IO treatments without acupuncture (Group B); or standard 
   care only (Group C). Mean arterial pressure (MAP), heart rate (HR), MAP 
   variability (mean of MAP standard deviation), bispectral index (BIS), and 
   calculated blood pressure Average Real Variability (ARV) were measured 
   intraoperatively. RESULTS: A total of 91 patients participated: Group A, 41; 
   Group B, 24; Group C, 26. Among patients undergoing open laparotomy, Group A 
   showed lower and more stable MAP and HR compared to Group B, (MAP, p = 0.026; HR, 
   p = 0.029) and Group C (MAP, p = 0.025). Mean BIS, from incision to suture 
   closing, was lower in Group A (vs. controls, p = 0.024). In patients undergoing 
   laparoscopic surgery, MAP was elevated within Group A (p = 0.026) throughout 
   surgery, with MAP variability significantly higher in Group A (P = 0.023) and 
   Group B (P = 0.013) 10 min post-incision (vs. pre-incision). All groups showed 
   similar intraoperative and post-anesthesia use of analgesic medication. 
   CONCLUSION: Intraoperative acupuncture was shown to reduce and stabilize MAP and 
   HR, and reduce BIS in gynecology oncology patients undergoing laparotomy, with no 
   impact on perioperative analgesic medication use. In the laparoscopic setting, 
   intraoperative acupuncture was associated with elevated MAP. Further research is 
   needed to explore the hemodynamic and BIS-associated benefits and risks of 
   intraoperative acupuncture, and the impact on the use of analgesic drugs in 
   response to these changes.
C1 Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, 35 Rothschild St, Haifa, Israel.eranben@netvision.net.il.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 
   Department of Anesthesiology, Critical Care and Pain Medicine, Carmel Medical Center, Haifa, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
   Department of Anesthesiology, Critical Care and Pain Medicine, Carmel Medical Center, Haifa, Israel.
   Department of Urology and Winship Cancer Institute of Emory University, Atlanta, GA, USA.
   Department of Anesthesiology, Critical Care and Pain Medicine, Carmel Medical Center, Haifa, Israel.
   Center for Integrative Complementary Medicine, Faculty of Medicine, Shaarei Zedek Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.
   Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel.
   Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, 35 Rothschild St, Haifa, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 
   Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
   Integrative Oncology Program, The Oncology Service, Lin, Zebulun, and Carmel Medical Centers, Clalit Health Services, 35 Rothschild St, Haifa, Israel.
   Department of Anesthesiology, Critical Care and Pain Medicine, Carmel Medical Center, Haifa, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Department of Internal Medicine & Integrative Medicine Service, Bnai-Zion, 
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
NR 0
TC 0
SN 1432-133
EI 0171-521
J9 J Cancer Res Clin Oncol
PD APR 16
PY 2023
VL 149
IS 11
BP 8177
EP 8189
DI 10.1007/s00432-023-04758-3 
PG 12
WC Female; Humans; Acupuncture Analgesia; Anesthesia; Acupuncture Therapy; Analgesics; Neoplasms
UT PubMed:37061627
PM 37061627
DA 2023-04-16
ER

PT J
AU Pu, JK
   Wong, SC
   So, KH
   Tsang, AC
   Li, LF
AF Pu, Jenny Kan-Suen
   Wong, Sanna Ching-Shan
   So, Karen Hoi-Ting
   Tsang, Anderson Chun-On
   Li, Lai-Fung
TI Acupuncture as Part of Iatrogenic Facial Nerve Palsy Rehabilitation-First Report.
SO World neurosurgery
LA English
DT Journal Article
DE Acoustic; Acupuncture therapy; Facial paralysis; Neuroma; Postoperative complications
AB BACKGROUND: Facial paresis is one of the complications after treatment for 
   vestibular schwannoma (VS). Acupuncture has been used for Bell palsy but not in 
   iatrogenic facial paresis. The objective of this study is to measure the efficacy 
   of using acupuncture for iatrogenic facial nerve palsy and patients' 
   satisfaction. METHODS: This is a single-center retrospective study with patients 
   from 2007-2019 received treatment for newly diagnosed or recurrent VS. Some 
   patients who suffered facial paresis after surgery had self-initiated 
   acupuncture. All patients who had facial paresis were included. Their facial 
   nerve status before and immediately after surgery, postoperative 6 months and 12 
   months, were recorded. Those who received acupuncture also answered 6- and 
   12-month patient satisfaction surveys over the phone. Adverse effects were also 
   assessed. RESULTS: There were 123 patients in this period. Of these, 29 patients 
   had iatrogenic facial paresis and 23 of them received acupuncture. There was 
   significant improvement of facial paresis for the acupuncture group compared with 
   the nonacupuncture group at 6 and 12 months. More than 80% of patients who 
   received acupuncture were satisfied. They had motor improvement and experienced 
   less pain and tightness. No adverse effects were reported. CONCLUSIONS: 
   Acupuncture for postresection VS facial paresis seemed to speed up its recovery. 
   Both patients' recovery and satisfaction were good after acupuncture, and it 
   seemed to be a safe procedure in trained hands.
C1 Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.
   Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.
   Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.
   Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.
   Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.
EM llfrandom@gmail.com
NR 0
TC 0
SN 1878-876
EI 
J9 World Neurosurg
PD MAY 21
PY 2020
VL 140
IS 
BP e343
EP e347
DI 10.1016/j.wneu.2020.05.079 
PG 1
WC Acupuncture Therapy; methods; Adult; Aged; Facial Nerve Injuries; etiology; Facial Paralysis; etiology; Female; Humans; Iatrogenic Disease; Male; Middle Aged; Neuroma, Acoustic; therapy; Neurosurgical Procedures; adverse effects; Radiotherapy; adverse effects; Retrospective Studies
UT PubMed:32434036
PM 32434036
DA 2020-05-21
ER

PT J
AU McPhail, P
   Sandhu, H
   Dale, J
   Stewart-Brown, S
AF McPhail, P
   Sandhu, H
   Dale, J
   Stewart-Brown, S
TI Acupuncture in hospice settings: A qualitative exploration of patients' 
SO European journal of cancer care
LA English
DT Journal Article
DE acupuncture; grounded theory; hospice; qualitative; well-being
AB Whilst acupuncture has the potential to impact on many aspects of health and 
   well-being, including end-of-life care, there is little research regarding 
   patients' experiences of its effects within the context of palliative care in 
   hospice settings. The aim of this study was to address this gap, by exploring 
   patients' experiences of acupuncture within this setting. In-depth, 
   semi-structured interviews were conducted with a sample of eighteen patients who 
   had received acupuncture as part of hospice care. Transcription of data, with 
   thematic analysis, identified two overarching themes: (1) participant perceptions 
   of the effects of acupuncture including pain control, improved physical and 
   emotional health, spiritual well-being and awareness of health as a holistic 
   phenomenon; and (2) factors which participants believed enabled acupuncture to 
   have these effects including the quality of the practitioner relationship, 
   engagement of participants in the process of their treatment and prior 
   expectations that acupuncture could work. Acupuncture was found to be a highly 
   acceptable, accessible and popular treatment with positive holistic effects 
   reported across the domains of physical, mental and spiritual health and no 
   serious adverse effects. By enabling awareness of the holistic nature of health 
   and well-being, acupuncture was experienced as having the potential to contribute 
   to a better death, an emergent theory that needs testing in further studies. In 
   the meanwhile, the results of this study offer encouragement to hospices 
   currently providing or considering investing in acupuncture provision.
C1 Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
   Division of Health Sciences, Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
   Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
   Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
NR 0
TC 0
SN 1365-235
EI 
J9 Eur J Cancer Care (Engl)
PD JAN 13
PY 2018
VL 27
IS 2
BP e12802
EP e12802
DI 10.1111/ecc.12802 
PG 1
WC Acupuncture Therapy; psychology; Adult; Female; Hospice Care; methods; Humans; Male; Mental Health; Middle Aged; Neoplasms; psychology; Pain Management; methods; Palliative Care; methods; Patient Satisfaction; Qualitative Research; Spirituality; Young Adult
UT PubMed:29323766
PM 29323766
DA 2018-01-13
ER

PT J
AU Zou, X
   Yang, YC
   Wang, Y
   Pei, W
   Han, JG
   Lu, Y
   Zhang, MS
   Tu, JF
   Lin, LL
   Wang, LQ
   Shi, G
   Yan, SY
   Yang, JW
   Liu, CZ
AF Zou, Xuan
   Yang, Ying-Chi
   Wang, Yu
   Pei, Wei
   Han, Jia-Gang
   Lu, Yun
   Zhang, Mao-Shen
   Tu, Jian Feng
   Lin, Lu Lu
   Wang, Li-Qiong
   Shi, Guangxia
   Yan, Shi-Yan
   Yang, Jing-Wen
   Liu, Cun-Zhi
TI Electroacupuncture versus sham electroacupuncture in the treatment of 
SO BMJ open
LA English
DT Journal Article
DE COMPLEMENTARY MEDICINE; Endoscopic surgery; Functional bowel disorders; Gastrointestinal tumours
AB INTRODUCTION: Postoperative ileus (POI) is an inevitable complication of almost 
   all abdominal surgeries, which results in prolonged hospitalisation and increased 
   healthcare costs. Various treatment strategies have been developed for POI but 
   with limited success. Electroacupuncture (EA) might be a potential therapy for 
   POI. However, evidence from rigorous trials that evaluated the effectiveness of 
   EA for POI is limited. Thus, the aim of this study was to examine whether EA can 
   safely reduce the time to the first defecation after laparoscopic surgery in 
   patients with POI. METHODS AND ANALYSIS: This multicentre randomised 
   sham-controlled trial will be conducted in four hospitals in China. A total of 
   248 eligible participants with colorectal cancer who will undergo laparoscopic 
   surgery will be randomly allocated to an EA group and a sham EA group in a 1:1 
   ratio. Treatment will be performed starting on postoperative day 1 and continued 
   for four consecutive days, once per day. If the participant is discharged within 
   4 days after surgery, the treatment will cease on the day of discharge. The 
   primary outcome will be the time to first defecation. The secondary outcome 
   measures will include time to first flatus, tolerability of semiliquid and solid 
   food, length of postoperative hospital stay, postoperative nausea and vomiting, 
   abdominal distension, postoperative pain, postoperative analgesic, time to first 
   ambulation, blinding assessment, credibility and expectancy and readmission rate. 
   ETHICS AND DISSEMINATION: Ethics approval was obtained from the Ethics Committee 
   of Beijing University of Chinese Medicine (number 2020BZHYLL0116) and the 
   institutional review board of each hospital. The results will be disseminated 
   through peer-reviewed publications. This study protocol (V.3.0, 6 March 2020) 
   involves human participants and was approved by the ethics committees of Beijing 
   University of Chinese Medicine (number 2020BZHYLL0116), Beijing Friendship 
   Hospital Affiliated to Capital Medical University (number 2020-P2-069-01), 
   Beijing Chao-Yang Hospital Affiliated to Capital Medical University (number 
   2020-3-11-2), National Cancer Center/National Clinical Research Center for 
   Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
   Medical College (number 20/163-2359), and the Affiliated Hospital of Qingdao 
   University (number QYFYKYLL711311920). The participants gave informed consent to 
   participate in the study before taking part. TRIAL REGISTRATION NUMBER: 
   ChiCTR2000038444.
C1 International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing, China.
   Beijing Chao-Yang Hospital Affiliated to Capital Medical University, Beijing, China.
   The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
   The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China ysy20200927@163.comyangjw0626@126.com.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China ysy20200927@163.comyangjw0626@126.com.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD APR 17
PY 2022
VL 12
IS 4
BP e050000
EP e050000
DI 10.1136/bmjopen-2021-050000 
PG 1
WC Colorectal Neoplasms; complications; Electroacupuncture; methods; Humans; Ileus; etiology; Laparoscopy; adverse effects; Multicenter Studies as Topic; Postoperative Complications; therapy; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:35428615
PM 35428615
DA 2022-04-17
ER

PT J
AU Liu, T
   Yu, J
   Kuang, W
   Wang, X
   Ye, J
   Qiu, X
   Xi, W
   Zeng, Y
   Zou, H
   Liu, Y
AF Liu, Tong
   Yu, Jiani
   Kuang, Weichuan
   Wang, Xiaoyin
   Ye, Jiang
   Qiu, Xiaojia
   Xi, Wen
   Zeng, Yao
   Zou, Hanhong
   Liu, Yue
TI Acupuncture for uterine fibroids: Protocol for a systematic review of randomized 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Uterine fibroids represent the most common gynecological benign 
   tumors in reproductive females. Acupuncture has been applied as a therapeutic 
   modality in China to treat uterine fibroids. However, currently, few critical 
   systematic reviews regarding the effect of acupuncture on uterine fibroids have 
   been published. Our proposed review aims to evaluate the current evidence on the 
   efficacy of acupuncture for uterine fibroids. METHODS: A total of 7 databases 
   were searched from their inception to December 2018, including PubMed, Medline, 
   Embase, the Cochrane Central Register of Controlled Trials, the Chinese National 
   Knowledge Infrastructure database, the Chinese Biomedical database, and the 
   Wanfang database. The primary outcomes will be reduction in uterine volume and 
   number of fibroids. Secondary outcomes are pelvic or low-back pain, assessed by 
   Visual Analog Scale (VAS); Irregular menstrual periods; Low-abdominal pressure 
   symptoms such as frequent or urgent urination, or constipation and adverse 
   events. Data synthesis will be computed by RevManV.5.3.5 software when a 
   data-analysis is allowed. Methodological quality will be evaluated with the risk 
   of bias according to Cochrane Handbook. RESULTS: This study will provide 
   high-quality evidence of acupuncture for uterine fibroids. CONCLUSION: The 
   conclusion of this systematic review will provide evidence to judge whether 
   acupuncture is an effective therapeutic intervention for patients with uterine 
   fibroids. TRIAL REGISTRATION NUMBER: PROSPERO CRD42019120484.
C1 Department of Acupuncture and Rehabilitation, GuangDong Second Hospital of Traditional Chinese Medicine.
   Department of Rehabilitation Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong, China.
   Department of Acupuncture and Rehabilitation, GuangDong Second Hospital of Traditional Chinese Medicine.
   Department of Acupuncture and Rehabilitation, GuangDong Second Hospital of Traditional Chinese Medicine.
   Department of Acupuncture and Rehabilitation, GuangDong Second Hospital of Traditional Chinese Medicine.
   Department of Acupuncture and Rehabilitation, GuangDong Second Hospital of Traditional Chinese Medicine.
   Department of Acupuncture and Rehabilitation, GuangDong Second Hospital of Traditional Chinese Medicine.
   Department of Acupuncture and Rehabilitation, GuangDong Second Hospital of Traditional Chinese Medicine.
   Department of Acupuncture and Rehabilitation, GuangDong Second Hospital of Traditional Chinese Medicine.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD MAR 1
PY 2019
VL 98
IS 8
BP e14631
EP e14631
DI 10.1097/MD.0000000000014631 
PG 1
WC Acupuncture Therapy; adverse effects; Female; Humans; Leiomyoma; therapy; Randomized Controlled Trials as Topic; Research Design; Treatment Outcome; Uterus; pathology; Systematic Reviews as Topic
UT PubMed:30813200
PM 30813200
DA 2019-03-01
ER

PT J
AU Wong, R
   Major, P
   Sagar, S
AF Wong, Raimond
   Major, Pierre
   Sagar, Stephen
TI Phase 2 Study of Acupuncture-Like Transcutaneous Nerve Stimulation for 
SO Integrative cancer therapies
LA English
DT Journal Article
DE ALTENS; Acupuncture; TENS; chemotherapy; neuropathy
AB A prospective phase 2 study was conducted to evaluate the clinical utility of 
   acupuncture-like transcutaneous nerve stimulation (ALTENS) for the treatment of 
   chemotherapy-induced peripheral neuropathy (CIPN). Eligible cancer patients had a 
   < 2 ECOG performance score, received neurotoxic chemotherapy, and developed CIPN 
   symptoms for > two months. Randomization was used to eliminate bias in patient 
   selection for ALTENS and was not to compare the effectiveness between the two 
   treatments.ALTENS treatments were delivered using Codetron units. Bilateral 
   acupuncture points included LI4 and LIV3, plus LI11 or ST36 were stimulated. 
   Acupuncture treatments were administered to CV6, SP6, ST6, LI11, Bafeng, Baxie 
   and selective Jing points bilaterally. Twelve treatments were delivered twice 
   weekly over 6 to 8 weeks. The Modified Total Neuropathy Score (mTNS), Numbness 
   Score, and Edmonton Symptom Assessment Score (ESAS) were assessed at baseline, 
   treatment completion, plus at 3 and 6 months follow-up. The primary study 
   endpoint was mTNS score at 6 months. We planned to recruit 23 patients into each 
   group. After 30 patients were recruited, 2 were lost to follow-up at 3 months in 
   the ALTENS group and 3 in the acupuncture group. The research team decided to 
   recruit all remaining consecutive patients only to the ALTENS group to ensure an 
   adequate evaluation of ALTENS, the primary object of evaluation. There were 27 
   patients in the ALTENS group, with an average symptom duration of 10 months after 
   chemotherapy. Twenty four and 23 patients completed the 3 and 6 month follow-up 
   respectively. The median mTNS scores were 7.1, 4.0, 3.6 and 3.1 at baseline, 
   treatment completion, 3 and 6 months follow-up, respectively. One-way ANOVA 
   analysis showed a significant improvement in mTNS scores (p<0.001) at 6 months. 
   Numbness scores were also significantly improved at 6 months. ESAS pain scores 
   and perception of well-being scores analyses were inconclusive. There were no 
   significant reported side effects of ALTENS. There were only 13 patients in the 
   acupuncture group and the number was insufficient for either an independent or a 
   comparative analysis. The results of this study suggests that ALTENS 
   significantly reduces the mTNS scores and numbness in patients suffering from 
   CIPN symptoms.
C1 McMaster University-Juravinski Cancer Centre, Hamilton, ON, Canada wongrai@hhsc.ca.
   McMaster University-Juravinski Cancer Centre, Hamilton, ON, Canada.
   McMaster University-Juravinski Cancer Centre, Hamilton, ON, Canada.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD MAY 1
PY 2016
VL 15
IS 2
BP 153
EP 64
DI 10.1177/1534735415627926 
PG -89
WC Acupuncture Therapy; methods; Adult; Aged; Antineoplastic Agents; adverse effects; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasms; drug therapy; Peripheral Nervous System Diseases; chemically induced; Prospective Studies; Transcutaneous Electric Nerve Stimulation; methods
UT PubMed:27130723
PM 27130723
DA 2016-05-01
ER

PT J
AU Oh, PJ
   Kim, YL
AF Oh, Pok Ja
   Kim, You Lim
TI [Effectiveness of Non-Pharmacologic Interventions in Chemotherapy Induced 
SO Journal of Korean Academy of Nursing
LA kor
DT Journal Article
DE Chemotherapy, Adjuvant; Meta-analysis; Peripheral Nervous System Diseases
AB PURPOSE: This study was conducted to evaluate the effectiveness of 
   non-pharmacologic interventions in chemotherapy-induced peripheral neuropathy 
   (CIPN). METHODS: PubMed, Cochrane Library CENTRAL, EMBASE, CINAHL, and several 
   Korean databases (Until August 2017) were searched. The main search strategy 
   combined terms for peripheral neuropathy and presence of neoplasms. The risk of 
   bias was assessed using the Cochrane's Risk of Bias tool for randomized studies 
   and the Risk of Bias Assessment tool for non-randomized studies. To estimate the 
   effect size, a meta-analysis of the studies was performed using the Rev Man 5.3 
   program of the Cochrane Library random-effects models were used in the analyses. 
   RESULTS: Twenty-two studies with a total of 954 participants met the inclusion 
   criteria. Of the 22 studies, 12 were used to estimate the effect size of the 
   non-pharmacologic interventions. The non-pharmacologic interventions used in 
   patients with CIPN were exercise, acupuncture, massage, and foot bath. The 
   acupuncture significantly reduced CIPN symptoms and signs (d=-0.71) and CIPN pain 
   (d=-0.73) (p<.001). Massage and foot bath were also effective in reducing CIPN 
   symptoms (d=-0.68; 95% CI=-1.05, -0.30; p<.001; I²=19%).Exercises were effective 
   in improving muscle strength and endurance(d=-0.55) and quality of life 
   (d=-2.96), but they were not significantly effective in improving CIPN. 
   CONCLUSION: Although these results provide little evidence of the effectiveness 
   of acupuncture, massage, and foot bath in the treatment of CIPN, they suggest 
   that these interventions can reduce CIPN symptoms in patients with cancer. 
   However, the findings of this study should be interpreted with caution as there 
   is a relative lack of data in this field, and additional well-designed studies 
   are needed. PROSPERO registration: CRD42017076278.
C1 Department of Nursing, Sahmyook University, Seoul, Korea.
   Department of Physical Therapy χ Laboratory of Rehabilitation & Health Science, Sahmyook University, Seoul, Korea. youlimy81@naver.com.
NR 0
TC 0
SN 2093-758
EI 
J9 J Korean Acad Nurs
PD MAY 8
PY 2018
VL 48
IS 2
BP 123
EP 142
DI 10.4040/jkan.2018.48.2.123 
PG 19
WC Acupuncture Therapy; Antineoplastic Agents; adverse effects; Baths; Databases, Factual; Exercise; Humans; Massage; Neoplasms; drug therapy; Peripheral Nervous System Diseases; etiology; Quality of Life
UT PubMed:29735874
PM 29735874
DA 2018-05-08
ER

PT J
AU Hao, J
   Zhu, X
   Bensoussan, A
AF Hao, Jie
   Zhu, Xiaoshu
   Bensoussan, Alan
TI Effects of Nonpharmacological Interventions in Chemotherapy-Induced Peripheral 
SO Integrative cancer therapies
LA English
DT Review
DE chemotherapy-induced peripheral neuropathy; meta-analysis; nonpharmacological intervention; overview; systematic review
AB INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the 
   prevalent and disabling side effects of cancer treatment. However, management 
   strategies for CIPN currently remain elusive, with treatment restricted to 
   neuropathic pain medications, supportive care, and chemotherapy dosing 
   adjustments. This overview explores evidence on the potential benefits and safety 
   of nonpharmacological interventions in preventing and treating CIPN in cancer 
   patients. METHODS: Seven databases were searched for systematic reviews of 
   randomized controlled trials (RCTs). The methodological quality of the selected 
   reviews was assessed by AMSTAR 2, and the quality of evidence was judged by 
   GRADE. Twenty-eight systematic reviews were considered eligible for this review. 
   RESULTS: It was found that nonpharmacological interventions (acupuncture, 
   exercise, herbal medicine, nutritional supplements) provided potential benefits 
   for patients with CIPN. Furthermore, Chinese herbal medicine, administered orally 
   or externally, significantly prevented and/or relieved the incidence and severity 
   of CIPN in comparison to control groups (no additional treatment, placebo, and 
   conventional western medicine). However, the quality of evidence and strength of 
   recommendations were compromised by the inconsistencies and imprecision of 
   included studies. The main concerns regarding the quality of systematic reviews 
   included the lack of sufficiently rigorous a priori protocols, and the lack of 
   protocol registration adopted in the included studies. CONCLUSIONS: Though 
   looking across reviews, Chinese herbal medicine appear generally effective in 
   CIPN, uncertainty remains about the effects of many other nonpharmacological 
   interventions. The evidence on what works was particularly compromised by 
   reporting and methodological limitations, which requires further investigation to 
   be more certain of their effects.
C1 Western Sydney University, Sydney, New South Wales, Australia.
   Western Sydney University, Sydney, New South Wales, Australia.
   Western Sydney University, Sydney, New South Wales, Australia.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD SEP 3
PY 2020
VL 19
IS 
BP 1534735420945027
EP 1534735420945027
DI 10.1177/1534735420945027 
PG 1
WC Acupuncture Therapy; Antineoplastic Agents; adverse effects; Humans; Meta-Analysis as Topic; Neoplasms; drug therapy; Peripheral Nervous System Diseases; chemically induced; Systematic Reviews as Topic
UT PubMed:32875921
PM 32875921
DA 2020-09-03
ER

PT J
AU Jing, M
   Zhang, Y
   Shen, Y
   Peng, Y
   Wang, H
AF Jing, Mengjiao
   Zhang, Yuanyuan
   Shen, Yuanjuan
   Peng, Yongjun
   Wang, Hesheng
TI [Effects of thumbtack-needle embedding therapy of auricular acupuncture on 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE 16S rRNA; gastric cancer; gastrointestinal function; intestinal microflora; thumbtack-needle embedding therapy of auricular acupuncture
AB OBJECTIVE: To observe the effects of thumbtack-needle embedding therapy of 
   auricular acupuncture on gastrointestinal function and intestinal microflora in 
   the patients with gastric cancer after operation, and to explore its mechanism. 
   METHODS: A total of 80 patients with gastric cancer after radical operation were 
   randomly divided into an observation group (40 cases, 3 cases discontinued) and a 
   control group (40 cases, 3 cases discontinued). The patients of both groups 
   received the perioperative care for accelerating recovery. Additionally, in the 
   observation group, the thumbtack-needle embedding therapy of auricular 
   acupuncture was delivered at the auricular points of unilateral side, including 
   Wei (CO(4)), Pi (CO(13)), Dachang (CO(7)), Xiaochang (CO(6)), Yuanzhong 
   (AT(2,3,4i)), Erzhong (HX(1)), Sanjiao (CO(17)) and Jiaowozhong (TF(3)), and the 
   needles were embedded and retained for 72 h. The postoperative recovery time of 
   gastrointestinal function (the postoperative bowel sound recovery time, the first 
   exhaust time, the first defecation time), the postoperative hospital stay and 
   pain visual analogue scale (VAS) score were observed in the two groups. Before 
   operation and on day 5 after operation, the serum gastrin level was detected in 
   the two groups. The third-generation 16S rRNA sequencing technology was used to 
   detect the composition and relative abundance of intestinal flora in the two 
   groups before and after operation. RESULTS: Compared with the control group, the 
   postoperative bowel sound recovery time, the first exhaust time and the first 
   defecation time were shortened in the observation group (P<0.05). In the 
   observation group, the VAS scores at 24 h, 48 h, and 72 h after surgery were 
   lower than those of the control group, respectively (P<0.05). There was no 
   significant differences in postoperative hospital stay and serum gastrin level 
   between the two groups (P>0.05). The alpha diversity analysis showed that the 
   differences in Shannon index, Simpson index, Pielou_J index and Pd_fath index 
   were not significant statistically after intervention between the two groups 
   (P>0.05). After intervention, the community structure of the fecal sample was 
   similar at each taxonomic level between the two groups, and although the 
   proportion between species was various, the difference was not significant 
   (P>0.05). After intervention, there were 55 species with the differences between 
   the two groups, 17 species of them presented significant difference in relative 
   abundance in the observation group and 38 species in the control group. Regarding 
   the level of genus, the levels of Klebsiell and Enterobacter increased (P<0.05) 
   and the level of Streptococcus decreased (P<0.05) in the observation group. The 
   main microbial groups that played an important role were Coprobacillaceae, 
   Sutterellaceae and Yersiniaceae in the observation group. KEGG function 
   prediction indicated that the function of intestinal microflora was mainly 
   associated with the cofactor and vitamin metabolism, carbohydrate metabolism, and 
   amino acid metabolism. CONCLUSION: The thumbtack-needle embedding therapy of 
   auricular acupuncture improves the postoperative gastrointestinal function of the 
   patients with gastric cancer probably through regulating the structure and 
   relative abundance of intestinal microflora and affecting the energy metabolism.
C1 Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
   Department of Nursing, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
   Department of Nursing, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
   Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
   Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAR 18
PY 2025
VL 45
IS 3
BP 300
EP 311
DI 10.13703/j.0255-2930.20240813-k0005 
PG 11
WC Humans; Male; Female; Middle Aged; Acupuncture, Ear; instrumentation; Gastrointestinal Microbiome; Aged; Stomach Neoplasms; microbiology; Adult; Acupuncture Points; Gastrointestinal Tract; physiopathology; Intestines; microbiology; Postoperative Period; Acupuncture Therapy
UT PubMed:40097211
PM 40097211
DA 2025-03-18
ER

PT J
AU Cai, GW
   Li, J
   Xu, XJ
   Xue, YZ
   Li, G
   Wu, M
   Li, PF
AF Cai, Guo-Wei
   Li, Jing
   Xu, Xiao-Juan
   Xue, Yuan-Zhi
   Li, Gang
   Wu, Man
   Li, Peng-Fei
TI [Clinical research on warm acupuncture therapy for pain in postmenopausal 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB OBJECTIVE: To observe the clinical efficacy on pain in postmenopausal 
   osteoporosis treated with the warm acupuncture therapy and discuss its effect 
   mechanism. METHODS: Ninety cases of postmenopausal osteoporosis were randomized 
   into a warm acupuncture group, an electroacupuncture group and a medication 
   group, 30 cases in each group. In the warm acupuncture group and the 
   electroacupuncture group, Dazhu (BL 11), Shenshu (BL 23) and Xuanzhong (GB 39) 
   were selected bilaterally and stimulated with the warm acupuncture and 
   electroacupuncture therapies respectively, once a day for 30 days totally. In the 
   medication group, caltrate-D tablets were prescribed, 600 mg, once a day for 30 
   days totally. The changes in the bone density T value, visual analogue scale 
   (VAS) score, serum insulin like growth factor 1 (IGF-1), interleukin 6 (IL-6) and 
   tumor necrosis factor (TNF-alpha) were observed before and after treatment in the 
   three groups. RESULTS: (1) The bone density T value in the patients of 
   postmenopausal osteoporosis did not change obviously after 30 days treatment with 
   the three therapies; (2) VAS score was all reduced after treatment, in which, the 
   result in the warm acupuncture group was the most obvious (6.73 +/- 0.24 before 
   treatment vs 4.43 +/- 0.26 after treatment). The value after treatment in the 
   warm acupuncture group was different significantly as compared with the 
   electroacupuncture group (5.13 +/- 0.31) and the medication group (5.17 +/- 0.33, 
   both P < 0.05). (3) The level of serum IGF-1 was improved after treatment in the 
   warm acupuncture therapy [(119.5 +/- 20.1) ng/mL before treatment vs (156.5 +/- 
   23.9) ng/mL after treatment], which was more apparent as compared with the 
   electroacupuncture group [(136.3 +/- 24.5) ng/mL] and the medication group 
   [(127.7 +/- 22.1) ng/mL, all P < 0.05]. Concerning to reducing the levels of IL-6 
   and TNF-alpha in serum, the results in the warm acupuncture group were superior 
   to the other two groups (all P < 0.05). CONCLUSION: The warm acupuncture therapy 
   achieves the significant efficacy on pain in postmenopausal osteoporosis, which 
   could be related to increasing the level of IGF-1, decreasing the levels of IL-6 
   and TNF-alpha, promoting bone formation and inhibting bone absorption.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAR 29
PY 2014
VL 34
IS 1
BP 25
EP 7
DI 
PG -18
WC Acupuncture Therapy; methods; Bone Density; Female; Humans; Insulin-Like Growth Factor I; metabolism; Interleukin-6; blood; Middle Aged; Osteoporosis, Postmenopausal; blood; Pain Management; Tumor Necrosis Factor-alpha; blood
UT PubMed:24673048
PM 24673048
DA 2014-03-29
ER

PT J
AU Magee, DJ
   Schutzer-Weissmann, J
   Pereira, EAC
   Brown, MRD
AF Magee, David J
   Schutzer-Weissmann, John
   Pereira, Erlick A C
   Brown, Matthew R D
TI Neuromodulation techniques for cancer pain management.
SO Current opinion in supportive and palliative care
LA English
DT Review
AB PURPOSE OF REVIEW: Advanced pain management techniques may be indicated in 5-15% 
   of cancer patients. Despite this, a recent review identified that, over the 
   course of 1 year in England, only 458 patients received a procedure intended to 
   provide analgesia and only 30 patients had intrathecal drug delivery (ITDD) 
   devices implanted. This article describes the emerging evidence for ITDD in 
   cancer pain and provides a narrative review of other neuromodulatory techniques 
   (including spinal cord stimulation, peripheral nerve stimulation and 
   acupuncture), approaches that might be employed to address this area of 
   significant unmet clinical need. RECENT FINDINGS: Numerous studies have been 
   published within the last year reporting positive outcomes associated with ITDD 
   in cancer pain management. Neuromodulation represents an important strategy in 
   the management of persistent pain. Whilst the nonmalignant pain evidence-base is 
   rapidly growing, it remains sparse for cancer pain management. The growing cohort 
   of cancer survivors may significantly benefit from neuromodulatory techniques. 
   SUMMARY: ITDD and other neuromodulatory techniques for cancer pain management 
   appear underutilised in the UK and offer the prospect of better treatment for 
   cancer patients with refractory pain or intolerable side-effects from systemic 
   analgesics.
C1 Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research.
   Pain Medicine Department, The Royal Marsden Hospital.
   Pain Medicine Department, The Royal Marsden Hospital.
   Neurosciences Research Centre, Molecular and Clinical Sciences Institute, St George's, University of London.
   Department of Neurosurgery, St George's University Hospital.
   Pain Medicine Department, The Royal Marsden Hospital.
   Targeted Approaches to Cancer Pain Group, The Institute of Cancer Research, 
NR 0
TC 0
SN 1751-426
EI 
J9 Curr Opin Support Palliat Care
PD APR 13
PY 2021
VL 15
IS 2
BP 77
EP 83
DI 10.1097/SPC.0000000000000549 
PG 6
WC Analgesics; Cancer Pain; drug therapy; Humans; Neoplasms; complications; Pain; Pain Management
UT PubMed:33843762
PM 33843762
DA 2021-04-13
ER

PT J
AU Lemanne, D
   Maizes, V
AF Lemanne, Dawn
   Maizes, Victoria
TI Advising Women Undergoing Treatment for Breast Cancer: A Narrative Review.
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Review
DE cancer; dietary supplements; integrative therapies; intermittent fasting; nutrition; stress management
AB A majority of women undergoing conventional treatment for breast cancer also 
   undertake complementary and integrative approaches. Practitioners knowledgeable 
   about the evidence base behind common integrative approaches can help patients 
   attain improved quality of life, and at times, improved survival. Evidence-based 
   recommendations include the following: a plant-based diet for general health 
   after diagnosis, and carbohydrate restriction for patients with estrogen 
   receptor-positive postmenopausal breast cancer may be prudent. Other dietary 
   recommendations include a 13-h daily overnight fast. Carefully selected patients 
   may choose to fast the day before and the day of chemotherapy to decrease side 
   effects. Specific food recommendations include avoidance or limitation of 
   alcohol, and liberal culinary use of cruciferous vegetables, coffee, green tea, 
   soy, and flaxseed. Promising supplements include diindolylmethane and melatonin. 
   Omega 3 fatty acids may help with bone density in patients on aromatase 
   inhibitors, but may increase chemotherapy resistance. Findings regarding the 
   usefulness of multivitamins, vitamin D, vitamin C, and vitamin E are weak and/or 
   mixed different exercise modalities may have different effects and thus play 
   different roles in breast cancer therapy. Aerobic and resistance training 
   combined during breast cancer chemotherapy may confer a survival benefit, while 
   yoga may improve outcome in lymphedema patients. Current evidence suggests that 
   meditation, yoga, breathing, music therapy, guided imagery, and hypnosis may 
   improve mood and quality of life during breast cancer treatment. Acupuncture is 
   useful for treating side effects of breast cancer therapies, including hot 
   flushes, aromatase inhibitor-induced joint pain, chemotherapy-induced peripheral 
   neuropathy, and vulvodynia. Vaginal moisturizers and vaginal rings supplying 
   low-dose estrogen can be useful in the treatment of symptoms of 
   estrogen-deprivation states caused by breast cancer treatments; such symptoms 
   include vaginal dryness, dyspareunia, and sexual dysfunction. Carbon dioxide 
   laser technology can rejuvenate atrophied vaginal mucosa and relieve dyspareunia, 
   allowing avoidance of estrogen therapy. Tertiary sexual health centers are 
   available for referral.
C1 1 The University of Arizona Center for Integrative Medicine , Tucson, Arizona.
   2 Oregon Integrative Oncology , Ashland, Oregon.
   3 National Institute of Integrative Medicine , Melbourne, Australia .
   1 The University of Arizona Center for Integrative Medicine , Tucson, Arizona.
NR 0
TC 0
SN 1557-770
EI 
J9 J Altern Complement Med
PD SEP 25
PY 2018
VL 24
IS 9-10
BP 902
EP 909
DI 10.1089/acm.2018.0150 
PG 7
WC Acupuncture Therapy; Breast Neoplasms; therapy; Diet Therapy; Diet, Vegetarian; Dietary Supplements; Evidence-Based Medicine; Exercise; Fasting; Female; Health Knowledge, Attitudes, Practice; Humans; Integrative Oncology; Oncologists; Phytotherapy
UT PubMed:30247957
PM 30247957
DA 2018-09-25
ER

PT J
AU Yao, Y
   Zhang, X
   Ge, R
   Im, HS
   Yao, C
AF Yao, Yao
   Zhang, Xiping
   Ge, Renjie
   Im, Hee Shin
   Yao, Chang
TI [Electroacupuncture for the prevention of chemotherapy-induced peripheral 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE breast cancer; chemotherapy-induced peripheral neuropathy; electroacupuncture; randomized controlled trial (RCT)
AB OBJECTIVE: To investigate the clinical effect of electroacupuncture (EA) in 
   preventing chemotherapy-induced peripheral neuropathy (CIPN). METHODS: Fifty-two 
   patients with breast cancer in the regimen of taxane-assisted/neoadjuvant 
   chemotherapy, were randomly divided into an EA group (26 cases, 3 cases dropped 
   out) and a usual care (UC) group (26 cases, 1 case dropped out). In the UC group, 
   on the basis of standard chemotherapy regimen, the routine nursing was 
   administered. In the EA group, on the intervention as the UC group, EA was added, 
   the acupoints included Yintang (GV 24(+)), Baxie (EX-UE 9, the second one), 
   Waiguan (TE 5), Hegu (LI 4), Quchi (LI 11), Zusanli (ST 36), Yinlingquan (SP 9), 
   Sanyinjiao (SP 6), Taixi (KI 3), Taichong (LR 3), Xuanzhong (GB 39) and Bafeng 
   (EX-LE 10, the fourth one). Electric stimulation was attached to Taichong (LR 3) 
   and Sanyinjiao (SP 6) on the same side, with disperse-dense wave and the 
   frequency of 2 Hz/10 Hz, for 30 min. EA started one day before the first cycle of 
   chemotherapy, twice weekly in the first two weeks and once weekly in the rest 
   weeks of chemotherapy. The duration of the intervention with EA was 12 weeks. The 
   incidence of CIPN was compared in week 24 of the trial between the two groups. At 
   the baseline and in week 12 and 24 of the trial, the score of EORTC QLQ-CIPN20 
   (European Organization for Research and Treatment of Cancer on 
   chemotherapy-induced peripheral nerve toxicity quality of life questionnaire 20), 
   the score of TCM syndrome scale and the score of EORTC QLQ-C30 (European 
   Organization for Research and Treatment of Cancer on quality of life scale) were 
   observed in the two groups. At the baseline and in week 12 of the trial, the 
   sensory nerve conduction velocity (SCV) and the motor nerve conduction velocity 
   (MCV) was detected. RESULTS: In week 24 of the trial, the incidence of CIPN was 
   17.4% (4/23) in the EA group, lower than that (72.0%, 18/25) in the UC group 
   (P<0.001). The incidence of high-grade CIPN was 0% (0/23) in the EA group, lower 
   than that (28.0%, 7/25) in the UC group (P<0.05). In week 12 and 24 of the trial, 
   the scores for the sensory nerve symptom of EORTC QLQ-CIPN20 and the total scores 
   were higher when compared with the baseline in the UC group (P<0.001, P<0.05, 
   P<0.01). In week 24 of the trial, the score for the sensory nerve symptom of 
   EORTC QLQ-CIPN20 in the EA group was lower than that of the UC group (P<0.05). In 
   week 12 of the trial, SCV of the right superficial peroneal nerve was reduced 
   when compared with the baseline in the UC group (P<0.05), and SCV of the left 
   median nerve and the right superficial peroneal nerve was higher in the EA group 
   when compared with the UC group (P<0.05, P<0.01). In week 12 and 24 of the trial, 
   the scores for the secondary symptoms of TCM scale were decreased in the EA group 
   compared with the baseline (P<0.05), and the scores for the primary and secondary 
   symptoms, as well as the total scores of TCM scale were all higher than those of 
   the baseline in the UC group (P<0.01, P<0.001, P<0.05). In week 12 of the trial, 
   the scores for the primary and secondary symptoms, as well as the total score of 
   TCM scale in the EA group were lower than those of the UC group (P<0.05, P<0.01). 
   In week 24 of the trial, the score for the secondary symptoms and the total score 
   of TCM scale in the EA group were lower than those of the UC group (P<0.05). In 
   week 12 of the trial, the scores for fatigue, pain, nausea and vomiting in EORTC 
   QLQ-C30 were increased in comparison with the baseline in the UC group (P<0.05, 
   P<0.01); in week 24 of the trial, the score of the general health in EORTC 
   QLQ-C30 was elevated when compared with the baseline in the EA group (P<0.001), 
   and the scores for nausea and vomiting, loss of appetite were decreased in 
   comparison with the baseline (P<0.01). In week 12 of the trial, the score of the 
   general health in EORTC QLQ-C30 in the EA group was higher compared with the UC 
   group (P<0.01), and the scores for pain, nausea and vomiting were lower (P<0.01, 
   P<0.05). In week 24 of the trial, the score of the general health in EORTC 
   QLQ-C30 was higher in the EA group compared with the UC group (P<0.001), and the 
   score for loss of appetite was lower (P<0.05). CONCLUSION: Electroacupuncture 
   reduces the incidence and severity of CIPN, ameliorates nerve conduction velocity 
   and improves the quality of life of the patients.
C1 Department of Breast Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
   Department of Breast Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
   Department of Breast Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
   Department of Medical Statistics, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea.
   Department of Breast Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD DEC 11
PY 2024
VL 44
IS 12
BP 1388
EP 94
DI 10.13703/j.0255-2930.20240222-k0001 
PG -1294
WC Humans; Electroacupuncture; Female; Peripheral Nervous System Diseases; therapy; Middle Aged; Adult; Breast Neoplasms; drug therapy; Antineoplastic Agents; adverse effects; Aged
UT PubMed:39658376
PM 39658376
DA 2024-12-11
ER

PT J
AU Mao, JJ
   Ismaila, N
   Bao, T
   Barton, D
   Ben-Arye, E
   Garland, EL
   Greenlee, H
   Leblanc, T
   Lee, RT
   Lopez, AM
   Loprinzi, C
   Lyman, GH
   MacLeod, J
   Master, VA
   Ramchandran, K
   Wagner, LI
   Walker, EM
   Bruner, DW
   Witt, CM
   Bruera, E
AF Mao, Jun J
   Ismaila, Nofisat
   Bao, Ting
   Barton, Debra
   Ben-Arye, Eran
   Garland, Eric L
   Greenlee, Heather
   Leblanc, Thomas
   Lee, Richard T
   Lopez, Ana Maria
   Loprinzi, Charles
   Lyman, Gary H
   MacLeod, Jodi
   Master, Viraj A
   Ramchandran, Kavitha
   Wagner, Lynne I
   Walker, Eleanor M
   Bruner, Deborah Watkins
   Witt, Claudia M
   Bruera, Eduardo
TI Integrative Medicine for Pain Management in Oncology: Society for Integrative 
SO Journal of clinical oncology : official journal of the American Society of 
LA English
DT Journal Article
AB PURPOSE: The aim of this joint guideline is to provide evidence-based 
   recommendations to practicing physicians and other health care providers on 
   integrative approaches to managing pain in patients with cancer. METHODS: The 
   Society for Integrative Oncology and ASCO convened an expert panel of integrative 
   oncology, medical oncology, radiation oncology, surgical oncology, palliative 
   oncology, social sciences, mind-body medicine, nursing, and patient advocacy 
   representatives. The literature search included systematic reviews, 
   meta-analyses, and randomized controlled trials published from 1990 through 2021. 
   Outcomes of interest included pain intensity, symptom relief, and adverse events. 
   Expert panel members used this evidence and informal consensus to develop 
   evidence-based guideline recommendations. RESULTS: The literature search 
   identified 227 relevant studies to inform the evidence base for this guideline. 
   RECOMMENDATIONS: Among adult patients, acupuncture should be recommended for 
   aromatase inhibitor-related joint pain. Acupuncture or reflexology or acupressure 
   may be recommended for general cancer pain or musculoskeletal pain. Hypnosis may 
   be recommended to patients who experience procedural pain. Massage may be 
   recommended to patients experiencing pain during palliative or hospice care. 
   These recommendations are based on an intermediate level of evidence, benefit 
   outweighing risk, and with moderate strength of recommendation. The quality of 
   evidence for other mind-body interventions or natural products for pain is either 
   low or inconclusive. There is insufficient or inconclusive evidence to make 
   recommendations for pediatric patients. More research is needed to better 
   characterize the role of integrative medicine interventions in the care of 
   patients with cancer.Additional information is available at 
   https://integrativeonc.org/practice-guidelines/guidelines and 
   www.asco.org/survivorship-guidelines.
C1 Memorial Sloan Kettering Cancer Center, New York, NY.
   American Society of Clinical Oncology, Alexandria, VA.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   University of Michigan School of Nursing, Ann Arbor, MI.
   Lin & Carmel Medical Centers, Clalit Health Services
   Technion Faculty of Medicine, Haifa, Israel.
   College of Social Work, University of Utah, Salt Lake City, UT.
   Fred Hutchinson Cancer Research Center, Seattle, WA.
   Duke University School of Medicine Durham, NC.
   City of Hope Comprehensive Cancer Center, Duarte, CA.
   Thomas Jefferson. Sidney Kimmel Cancer Center, Philadelphia, PA.
   Mayo Clinic, Rochester, MN.
   Fred Hutchinson Cancer Research Center, Seattle, WA.
   Patient Representative, Memorial Sloan Kettering Integrative Medicine Service, New York, NY.
   Winship Cancer Institute of Emory University, Atlanta, GA.
   Stanford University, Palo Alto, CA.
   Wake Forest School of Medicine, Winston-Salem, NC.
   Henry Ford Hospital, Detroit, MI.
   Winship Cancer Institute of Emory University, Atlanta, GA.
   University Hospital Zurich, Zurich, Switzerland.
   MD Anderson Cancer Center, Houston, TX.
NR 0
TC 0
SN 1527-775
EI 
J9 J Clin Oncol
PD SEP 20
PY 2022
VL 40
IS 34
BP 3998
EP 4024
DI 10.1200/JCO.22.01357 
PG 26
WC Adult; Child; Humans; Integrative Medicine; Integrative Oncology; Neoplasms; complications; Pain; Pain Management
UT PubMed:36122322
PM 36122322
DA 2022-09-20
ER

PT J
AU Zhang, X
   Li, W
AF Zhang, Xinxin
   Li, Weihong
TI [Efficacy on endometriosis treated with electroacupuncture].
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB OBJECTIVE: To compare the difference in the clinical efficacy on endometriosis 
   (EM) between electroacupuncture (EA) and western medication. METHODS: Seventy-two 
   EM patients were divided into an EA group and a western medication group 
   according to visiting departments, 36 cases in each one. In the EA group, 
   acupuncture was applied to Qihai (CV 6), Guanyuan (CV 4), Zhongji (CV 3), Zigong 
   (EX-CA 1), Diji (SP 8), Sanyinjiao (SP 6), Hegu (LI 4) and Taichong (LR 3). After 
   qi arrival, G6805-I pulse electronic apparatus was attached to bilateral Zigong 
   (EX-CA 1), Guanyuan (CV 4) and Zhongji (CV 3), with continuous wave, 70 Hz in 
   frequency, 3 mA in intensity. The EA was given once every two days. In the 
   western medication group, mifepristone tablets were prescribed for oral 
   administration, 12. 5 mg per treatment, once a day, for 6 months. The pain degree 
   was observed before and after treatment and the clinical efficacy and recurrence 
   rate were evaluated in the two groups. The enzyme-linked immunoassay (ELISA) was 
   adopted to determine the tumor marker serum CA125 before and after treatment in 
   the two groups. RESULTS: The total effective rate was 94. 4% (34/36) in the EA 
   group and was 91. 7% (33/36) in the western medication group, without significant 
   difference (P>0. 05). The pain score after treatment was lower than that before 
   treatment in the two groups (both P< 0. 01), but the score after treatment in the 
   EA group was lower than that in the western medication group (P<0. 05). Serum 
   CA125 was reduced after treatment in the patients of the two groups (both P<0. 
   01), and serum CA125 after treatment in the EA group was lower than that in the 
   western medication group (P<0. 05). In the follow-up visit of one year, the 
   reoccurrence rate was 17. 6% (6/34) in the EA group and was 33. 3% (11/33) in the 
   western medication group, indicating the significant difference (P<0. 05). 
   CONCLUSION: EA achieves the significant clinical efficacy and the reoccurrence 
   rate in 1 year in the EA group is obviously lower than that in the western 
   medication group. This therapy could be promoted in clinical practice of 
   acupuncture and moxibustion.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUN 10
PY 2015
VL 35
IS 4
BP 323
EP 6
DI 
PG -317
WC Acupuncture Points; Adult; Electroacupuncture; Endometriosis; therapy; Female; Humans; Middle Aged; Treatment Outcome; Young Adult
UT PubMed:26054137
PM 26054137
DA 2015-06-10
ER

PT J
AU Zhang, S
   Luo, J
   Zeng, Y
   Ren, H
   Chen, Z
   Ren, Y
AF Zhang, Su
   Luo, Jun
   Zeng, YiWei
   Ren, Huan
   Chen, Zhihan
   Ren, Yulan
TI Acupuncture for protracted amphetamine abstinence syndrome: study protocol for a 
SO BMJ open
LA English
DT Journal Article
DE complementary medicine; psychiatry; substance misuse
AB INTRODUCTION: Amphetamine-type stimulants (ATSs) are presenting a great challenge 
   to global public health along with its worldwide abuse in recent years. 
   Protracted amphetamine abstinence syndrome (PAAS) is one of the primary causes of 
   relapse for ATS abusers during withdrawal. However, different conclusions are 
   reached by previous trials. This study is designed to evaluate the efficacy and 
   safety of acupuncture in treating PAAS. METHODS AND ANALYSIS: Cochrane Central 
   Register of Controlled Trials, PubMed, Embase, Web of Science, Cumulative Index 
   to Nursing and Allied Health Literature (CINAHL), PsycINFO, ProQuest Dissertation 
   and Theses, Allied and Complementary Medicine Database (AMED), ClinicalTrials.gov 
   and who.int/trialsearch will be searched from the inception to February 2023 and 
   language will be restricted to English and Chinese. Eligible randomised 
   controlled trials will be included. The primary outcome is the intensity of 
   withdrawal syndrome. The secondary outcomes include: (1) intensity of pain, 
   anxiety, depression and other associated symptoms; (2) number of participants 
   with relapse; (3) retention of treatment and (4) nature and rate of adverse 
   effects. Data synthesis will be performed by using RevMan (V.5.4). The quality of 
   evidence will be evaluated by the Grading of Recommendations, Assessment, 
   Development and Evaluation approach. This study will strictly adhere to the 
   Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. 
   ETHICS AND DISSEMINATION: Ethical approval is not required as this is a 
   systematic review and meta-analysis based on previously published studies that do 
   not involve patients' privacy. The results of this study will be disseminated in 
   a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42022297761.
C1 School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   School of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   School of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu, China renxg2468@163.com.
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD APR 22
PY 2023
VL 13
IS 4
BP e062491
EP e062491
DI 10.1136/bmjopen-2022-062491 
PG 1
WC Humans; Amphetamine; Neoplasm Recurrence, Local; Systematic Reviews as Topic; Meta-Analysis as Topic; Acupuncture Therapy; methods; Chronic Disease; Research Design
UT PubMed:37085314
PM 37085314
DA 2023-04-22
ER

PT J
AU Katta, MR
   Valisekka, SS
   Agarwal, P
   Hameed, M
   Shivam, S
   Kaur, J
   Prasad, S
   Bethineedi, LD
   Lavu, DV
   Katamreddy, Y
AF Katta, Maanya Rajasree
   Valisekka, Sai Sudha
   Agarwal, Pahel
   Hameed, Maha
   Shivam, Swadha
   Kaur, Jasneet
   Prasad, Sakshi
   Bethineedi, Lakshmi Deepak
   Lavu, Diti Vinuthna
   Katamreddy, Yamini
TI Non-pharmacological integrative therapies for chronic cancer pain.
SO Journal of oncology pharmacy practice : official publication of the International 
LA English
DT Review
DE Chronic cancer pain; non-pharmacological; patient education; physical therapy; psychosocial therapy
AB OBJECTIVE: Chronic pain is one of the most detrimental symptoms exhibited by 
   cancer patients, being an indication for opioid therapy in up to half of the 
   patients' receiving chemotherapy and in 90% of advanced cases. Various successful 
   non-pharmacological integrative therapy options have been explored and 
   implemented to improve the quality of life in these patients. This review aims to 
   highlight the mechanisms implicated; assessment tools used for cancer pain and 
   summarize current evidence on non-pharmacological approaches in the treatment of 
   chronic cancer pain. DATA SOURCES: A review of the literature was conducted using 
   a combination of MeSH keywords including "Chronic cancer pain," "Assessment," 
   "Non-pharmacological management," and "Integrative therapy." DATA SUMMARY: Data 
   on the approach and assessment of chronic cancer pain as well as 
   non-pharmacological integrative options have been displayed with the help of 
   figures and tables. Of note, non-pharmacological integrative management was 
   divided into three subcategories; physical therapy (involving exercise, 
   acupuncture, massage, and transcutaneous electric nerve stimulation), 
   psychosocial therapy (e.g. mindful practices, supportive therapy), and herbal 
   supplementation. CONCLUSIONS: The use of non-pharmacological integrative therapy 
   in the management of chronic cancer pain has been grossly underestimated and must 
   be considered before or as an adjuvant of other treatment regimens to ensure 
   appropriate care.
C1 28577Gandhi Medical College, Hyderabad, Telangana, India.
   77058Sri Venkateshwara Medical College, Tirupati, AP, India.
   77034Bhaskar Medical College, Hyderabad, Telangana, India.
   288867AlFaisal University, College of Medicine, Riyadh, Kingdom of Saudi Arabia.
   77034Bhaskar Medical College, Hyderabad, Telangana, India.
   75257Government Medical College, Amritsar, India.
   Faculty of Medicine, National Pirogov Memorial Medical University, Vinnytsya, Ukraine.
   77033Andhra Medical College, Visakhapatnam, AP, India.
   28664Siddhartha Medical College, AP, India.
   24430West Anaheim Medical Center, CA, USA.
NR 0
TC 0
SN 1477-092
EI 
J9 J Oncol Pharm Pract
PD MAY 10
PY 2022
VL 28
IS 8
BP 1859
EP 1868
DI 10.1177/10781552221098437 
PG 9
WC Humans; Chronic Pain; therapy; Quality of Life; Cancer Pain; therapy; Massage; Neoplasms; complications
UT PubMed:35532081
PM 35532081
DA 2022-05-10
ER

PT J
AU Rosenscheg, M
   Pedron, J
   Pedroso, L
AF Rosenscheg, Marcelen
   Pedron, Julia
   Pedroso, Lorena
TI Treatment of Cancer Pain: A Systematic Review.
SO American journal of clinical oncology
LA English
DT Journal Article
AB CONTEXTUALIZATION: One of the biggest problems regarding the treatment of cancer 
   patients is pain, whether due to the cancer or the treatment itself. Therefore, 
   there is a search for treatments that aims to promote an effective treatment in 
   this sense. PURPOSE: This article aims to verify which are the recent methods 
   used to treat pain in cancer patients in a multidisciplinary sense, and to 
   evaluate their effectiveness. METHODOLOGY: Systematic reviews, meta-analyses and 
   randomized clinical trials utilizing the LILACS, NCBI, and MEDLINE platforms of 
   the last 5 years were included. The descriptors were pain treatment in oncology, 
   pain management, complementary therapies, and other synonyms, in Portuguese, 
   English and Spanish. This included any technique that was effective in the 
   treatment of cancer pain. RESULTS: The initial search found 2246 articles, of 
   which 22 were included in the systematic review. Most of these are acupuncture 
   treatments, opioids versus anti-inflammatories versus analgesics, radiotherapy, 
   behavioral therapies, among others. Most articles suggest benefits with these 
   therapies, improved quality of life for patients and tolerable side effects. 
   CONCLUSION: This study demonstrates the effectiveness of the current methods used 
   in the treatment of pain in cancer patients so that professionals in the area can 
   have more options for treating cancer pain. Despite the important limitations, 
   the guideline for further research and the situations in which treatments have 
   shown effectiveness are present in it.
C1 Bonding Institution, Centro Universitário Campo Real, Guarapuava-PR, Brazil.
NR 0
TC 0
SN 1537-453
EI 
J9 Am J Clin Oncol
PD JUL 24
PY 2023
VL 46
IS 10
BP 450
EP 458
DI 10.1097/COC.0000000000001029 
PG 8
WC Humans; Cancer Pain; therapy; Quality of Life; Pain; drug therapy; Pain Management; Analgesics, Opioid; therapeutic use; Neoplasms; therapy
UT PubMed:37482642
PM 37482642
DA 2023-07-24
ER

PT J
AU Kim, KH
   Lee, MS
   Choi, SM
AF Kim, Kun Hyung
   Lee, Myeong Soo
   Choi, Sun-Mi
TI Acupuncture for treating uremic pruritus in patients with end-stage renal 
SO Journal of pain and symptom management
LA English
DT Journal Article
AB Uremic pruritus (UP) is a common and bothersome symptom in end-stage renal 
   disease (ESRD) that does not always respond to conventional care. Acupuncture is 
   frequently used for the treatment of a wide range of conditions, but its effects 
   on UP in ESRD patients are unclear. The objective of this review was to evaluate 
   the effectiveness of acupuncture for UP in patients with ESRD. We searched 16 
   electronic databases from their inception to November 2009. All prospective 
   clinical studies of needle acupuncture for UP in hemodialysis patients with ESRD 
   were included regardless of their design. Risk of bias of the included studies 
   was assessed using the Cochrane criteria. Three randomized controlled trials and 
   three uncontrolled observational studies were included. All of the included 
   trials reported beneficial effects of acupuncture. However, most of the studies 
   showed high risk of bias, which leaves their reports unconvincing. The current 
   evidence is insufficient to show that acupuncture is an effective treatment for 
   UP inpatients with ESRD because of suboptimal quality and lack of methodological 
   rigor of included studies. Future trials should overcome the limitations of the 
   currently available evidence. J Pain Symptom Manage 2010;40:117e125. 2010 U.S. 
   Cancer Pain Relief Committee.
C1 Acpuncture, Moxibustion, & Meridian Research Center, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
NR 0
TC 0
SN 1873-651
EI 
J9 J Pain Symptom Manage
PD JUL 29
PY 2011
VL 40
IS 1
BP 117
EP 25
DI 10.1016/j.jpainsymman.2009.11.325 
PG -92
WC Acupuncture Therapy; methods; Bias; Electroacupuncture; methods; Humans; Kidney Failure, Chronic; complications; Pruritus; etiology; Randomized Controlled Trials as Topic; Uremia; complications
UT PubMed:21796811
PM 21796811
DA 2011-07-29
ER

PT J
AU Feuvret, L
   Cuenca, X
   Lavaud, P
   Anane, S
   Colin, E
AF Feuvret, L
   Cuenca, X
   Lavaud, P
   Anane, S
   Colin, E
TI [Pain management in radiation oncology].
SO Cancer radiotherapie : journal de la Societe francaise de radiotherapie 
LA fre
DT Journal Article
DE Anticipation; Douleurs; Pain; Plateau technique; Radiation department; Radiation therapy; Radiothérapie
AB The goal of this article is to propose some practical means of pain management in 
   radiation departments. Pain management in radiation oncology is difficult because 
   of the high proportion of painful patients, underestimation by medical teams, and 
   limited therapeutic options. Pain can cause mobilization difficulties, set-up 
   errors, treatment interruption. According to procedure steps, a preventive 
   attitude (for pre-radiation consultation) or an active attitude (for treatment) 
   to quickly relieve the patient can be planned. This work is a brain storming 
   about pain management. It is not a review about analgesic radiotherapy. The 
   practical situations apply to patients to whom radiotherapy is indicated. 
   Teamwork and anticipation are keywords to relieve patients. All proposed means 
   are not always available for different reasons (time, finance, staff, training). 
   The idea is to establish simple procedures that are appropriate to each center to 
   fluidify acts, to optimize time for a successful irradiation.
C1 Service d'oncologie radiothérapie, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France. 
EM oic.feuvret@psl.aphp.fr
NR 0
TC 0
SN 1769-665
EI 
J9 Cancer Radiother
PD AUG 21
PY 2013
VL 17
IS 5-6
BP 523
EP 7
DI 10.1016/j.canrad.2013.05.006 
PG -516
WC Acupuncture Therapy; Analgesics, Opioid; therapeutic use; Anti-Anxiety Agents; therapeutic use; Humans; Hypnosis; Muscle Relaxants, Central; therapeutic use; Neoplasms; psychology; Pain Management; methods; Patient Care Team; Physical Therapy Modalities; Radiotherapy; adverse effects
UT PubMed:23948427
PM 23948427
DA 2013-08-21
ER

PT J
AU Mi, WL
   Mao-Ying, QL
   Wang, XW
   Li, X
   Yang, CJ
   Jiang, JW
   Yu, J
   Wang, J
   Liu, Q
   Wang, YQ
   Wu, GC
AF Mi, Wen-Li
   Mao-Ying, Qi-Liang
   Wang, Xiao-Wei
   Li, Xiu
   Yang, Chang-Jiang
   Jiang, Jian-Wei
   Yu, Jin
   Wang, Jun
   Liu, Qiong
   Wang, Yan-Qing
   Wu, Gen-Cheng
TI Involvement of spinal neurotrophin-3 in electroacupuncture analgesia and 
SO The journal of pain
LA English
DT Journal Article
AB Although electroacupuncture (EA) has been proven to effectively relieve pain 
   associated with arthritis, the underlying mechanism of EA analgesia requires 
   further investigation. Here, the involvement of spinal neurotrophin-3 (NT-3) in 
   EA's analgesic effects on complete Freund's adjuvant (CFA)-induced inflammatory 
   pain was examined. The present study demonstrated that: 1) repeated EA 
   stimulation of ipsilateral GB30 and GB34 acupoints remarkably suppressed 
   CFA-induced hyperalgesia; 2) EA treatment markedly enhanced the upregulation of 
   spinal NT-3 mRNA and protein levels following CFA injection; 3) antisense 
   oligodeoxynucleotides (ODN) specifically against NT-3 intrathecally administered 
   during EA treatment for 7 days significantly attenuated the EA analgesia; and 4) 
   the suppressed expression of spinal GFAP (astrocytic marker), OX-42 (microglial 
   marker) as well as proinflammatory cytokines, interleukin (IL)-1β, IL-6 and tumor 
   necrosis factor (TNF)-α by EA treatment was significantly attenuated following 
   NT-3 antisense ODN delivery. These results suggested that endogenous NT-3 may be 
   involved in the analgesic effect of EA on inflammatory pain in rats, mediated 
   through the inhibition of spinal glial activity as well as proinflammatory 
   cytokine production. PERSPECTIVE: The present study may initiate a discussion on 
   the possible roles of NT-3/glia/cytokines in the therapeutic effects of 
   acupuncture and provide insight on the mechanism underlie the analgesic effects 
   of acupuncture on pain associated with arthritis.
C1 Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research, State Key Laboratory of Medical Neurobiology, Institutes of BrainScience, Shanghai Medical College, Fudan University, Shanghai, China.
NR 0
TC 0
SN 1528-844
EI 
J9 J Pain
PD JUN 18
PY 2011
VL 12
IS 9
BP 974
EP 84
DI 10.1016/j.jpain.2011.03.002 
PG -890
WC Analgesia; methods; Animals; Arthritis; metabolism; Disease Models, Animal; Electroacupuncture; methods; Inflammation Mediators; physiology; Male; Neural Inhibition; genetics; Neuroglia; metabolism; Neurotrophin 3; genetics; RNA, Messenger; biosynthesis; Rats; Rats, Sprague-Dawley; Spinal Cord; metabolism; Up-Regulation; genetics
UT PubMed:21680256
PM 21680256
DA 2011-06-18
ER

PT J
AU Liou, KT
   Ashare, R
   Worster, B
   Jones, KF
   Yeager, KA
   Acevedo, AM
   Ferrer, R
   Meghani, SH
AF Liou, Kevin T
   Ashare, Rebecca
   Worster, Brooke
   Jones, Katie F
   Yeager, Katherine A
   Acevedo, Amanda M
   Ferrer, Rebecca
   Meghani, Salimah H
TI SIO-ASCO guideline on integrative medicine for cancer pain management: 
SO JNCI cancer spectrum
LA English
DT Journal Article
AB Racial and ethnic disparities in pain management pose major challenges to 
   equitable cancer care delivery. These disparities are driven by complex 
   interactions between patient-, provider-, and system-related factors that resist 
   reductionistic solutions and require innovative, holistic approaches. On 
   September 19, 2022, the Society for Integrative Oncology and the American Society 
   of Clinical Oncology published a joint guideline to provide evidence-based 
   recommendations on integrative medicine for cancer pain management. Integrative 
   medicine, which combines conventional treatments with complementary modalities 
   from cultures and traditions around the world, are uniquely equipped to resonate 
   with diverse cancer populations and fill existing gaps in pain management. 
   Although some complementary modalities, such as music therapy and yoga, lack 
   sufficient evidence to make a specific recommendation, other modalities, such as 
   acupuncture, massage, and hypnosis, demonstrated an intermediate level of 
   evidence, resulting in moderate strength recommendations for their use in cancer 
   pain management. However, several factors may hinder real-world implementation of 
   the Society for Integrative Oncology and the American Society of Clinical 
   Oncology guideline and must be addressed to ensure equitable pain management for 
   all communities. These barriers include, but are not limited to, the lack of 
   insurance coverage for many complementary therapies, the limited diversity and 
   availability of complementary therapy providers, the negative social norms 
   surrounding complementary therapies, the underrepresentation of racial and ethnic 
   subgroups in the clinical research of complementary therapies, and the paucity of 
   culturally attuned interventions tailored to diverse individuals. This commentary 
   examines both the challenges and the opportunities for addressing racial and 
   ethnic disparities in cancer pain management through integrative medicine.
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
   Department of Psychology, State University of New York at Buffalo, Buffalo, NY, USA.
   Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
   Center for Aging and Serious Illness, Massachusetts General Hospital, Boston, MA, USA.
   Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
   Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA.
   Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA.
   Department of Biobehavioral Health Science, School of Nursing, University of Pennsylvania, Philadelphia, PA, USA.
NR 0
TC 0
SN 2515-509
EI 
J9 JNCI Cancer Spectr
PD JUN 12
PY 2023
VL 7
IS 4
BP 
EP 
DI 10.1093/jncics/pkad042 
PG 0
WC Humans; Cancer Pain; therapy; Complementary Therapies; Ethnic and Racial Minorities; Healthcare Disparities; Integrative Medicine; Integrative Oncology; Neoplasms; complications; Pain Management; methods; Practice Guidelines as Topic; Socioeconomic Disparities in Health; American Cancer Society
UT PubMed:37307074
PM 37307074
DA 2023-06-12
ER

PT J
AU Lee, PL
   Tam, KW
   Yeh, ML
   Wu, WW
AF Lee, Phoebe Lyssandra Tan
   Tam, Ka-Wai
   Yeh, Mei-Ling
   Wu, Wei-Wen
TI Acupoint stimulation, massage therapy and expressive writing for breast cancer: A 
SO Complementary therapies in medicine
LA English
DT Journal Article
DE Acupoint stimulation; Anxiety; Breast cancer; Expressive writing; Massage therapy; Meta-analysis; Pain; Quality of life; Systematic review
AB Researches have accumulated using non-pharmacologic interventions including 
   acupoint stimulation, massage therapy and expressive writing to manage breast 
   cancer-related symptoms. Results from randomized controlled trials (RCTs) can get 
   contradictory. OBJECTIVE: A systematic review and meta-analysis were conducted to 
   determine the effects on the quality of life, negative emotions and 
   disease-related symptoms among women with breast cancer. METHODS: Two independent 
   researchers performed a structured search using data sources including MEDLINE, 
   CINAHL, Cochrane Central Register of Controlled Trials, EMBASE, PubMed and 
   PsychINFO from the beginning of time until the first week of January 2015. A 
   total of 23 acupoint stimulation, massage therapy and expressive writing RCTs 
   were included in the review. RESULTS: The study showed that no single 
   intervention could be put under the spotlight exhibiting an overall effective 
   result on all measured outcomes; however, looking into each one in detail shows 
   different results in specific outcomes. Among the three interventions, acupoint 
   stimulation has a treatment effect for general pain (MD=-1.46, 95% CI=-2.38 to 
   -0.53) and fatigue (MD=-2.22, 95% CI=-3.68 to -0.77), massage therapy has a 
   treatment effect for anxiety (MD=-0.50, 95% CI=-0.77 to -0.24), and expressive 
   writing has a treatment effect for quality of life (MD=7.18, 95% CI=0.38 to 
   13.98). The measurement other outcomes showed either ineffective or equivocal 
   results. CONCLUSION: Non-pharmacologic interventions including acupoint 
   stimulation, massage therapy and expressive writing have an effect on a 
   middle-age woman with breast cancer. However, because of limitations, the 
   seemingly promising results should be interpreted with caution.
C1 School of Nursing, College of Nursing, National Taipei University of Nursing and Health Sciences, No. 365 Min-Te Road, Taipei 11219, Taiwan, ROC. Electronicaddress: phoebeelee@gmail.com.
   Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taiwan, ROC
   Division of General Surgery, Department of Surgery,Taipei Medical University-Shuang Ho Hospital, No. 250, Wu-Hsing Street., Wu-HsingDistrict, Taipei 11031, Taiwan, ROC. 
   Graduate Institute of Integration of Traditional Chinese Medicine with Western Nursing, College of Nursing, National Taipei University of Nursing & HealthSciences, No. 365, Min-Te Road, Taipei 11219, Taiwan, ROC. 
   School of Nursing, College of Nursing, National Taipei University of Nursing and Health Sciences, No. 365 Min-Te Road, Taipei 11219, Taiwan, ROC. Electronicaddress: weiwen@ntunhs.edu.tw.
EM eiling@ntunhs.edu.tw
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD AUG 16
PY 2016
VL 27
IS 
BP 87
EP 101
DI 10.1016/j.ctim.2016.06.003 
PG 14
WC Acupuncture Points; Adult; Aged; Aged, 80 and over; Breast Neoplasms; physiopathology; Female; Humans; Massage; psychology; Middle Aged; Randomized Controlled Trials as Topic; Writing
UT PubMed:27515882
PM 27515882
DA 2016-08-16
ER

PT J
AU Liu, CT
   Hsieh, TM
   Shih, FY
   Lai, WH
   Hsieh, CH
   Wu, BY
   Chen, YH
AF Liu, Chun-Ting
   Hsieh, Ting-Min
   Shih, Fu-Yuan
   Lai, Wei-Hung
   Hsieh, Ching-Hua
   Wu, Bei-Yu
   Chen, Yung-Hsiang
TI The effects of electroacupuncture and laser acupuncture therapy for patients with 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Major trauma is the leading cause of death in the young population. 
   The inflammatory and anti-inflammatory responses are associated with 
   posttraumatic morbidity and mortality; however, it is not fully clear how to 
   reestablish the homeostasis in patients with major trauma. METHODS: This study 
   will be a prospective, randomized, placebo-controlled, partially double-blinded, 
   three-armed trial. One hundred eighty participants diagnosed with major trauma 
   will be randomly assigned to an electroacupuncture (EA), a laser acupuncture 
   (LA), or a sham laser acupuncture group in a 1:1:1 ratio. All participants will 
   undergo EA, LA, or sham laser acupuncture intervention once a day on 5 acupoints 
   (LI4, PC6, ST36, SP6, and EX-HN1) for 14 consecutive days after enrollment. The 
   primary outcome measure will be the length of hospital stay. Secondary outcomes 
   will be inflammatory mediators, including serum C-reactive protein, interleukin 
   (IL)-6, tumor necrosis factor-α, IL-1β, and IL-10. Clinical outcomes will be 
   numeric rating scale scores for pain, sequential organ failure assessment, ICU 
   length of stay, 30-day mortality, and WHO Disability Assessment Schedule. Data 
   will be analyzed by chi-square test or t test for pairwise comparisons, as well 
   as one-way ANOVA followed by post hoc Tukey method between groups. OBJECTIVES: 
   The aim of this protocol is to investigate the clinical effects of EA and LA on 
   major trauma. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04970433. 
   Registered on July 21, 2021.
C1 Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
   Graduate Institute of Integrated Medicine, College of Chinese Medicine, Research 
   Department of Chinese Medicine, Dali Branch, Jen-Ai Hospital, Taichung, Taiwan.
   Division of Trauma Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
   Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
   Division of Trauma Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
   Division of Plastic and Reconstructive Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine,Kaohsiung, Taiwan.
   Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
   Graduate Institute of Integrated Medicine, College of Chinese Medicine, Research 
   Fooyin University College of Nursing, Kaohsiung, Taiwan.
   Graduate Institute of Integrated Medicine, College of Chinese Medicine, Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung,Taiwan.
   Department of Psychology, College of Medical and Health Science, Asia University, 
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD DEC 31
PY 2021
VL 100
IS 52
BP e28367
EP e28367
DI 10.1097/MD.0000000000028367 
PG 1
WC Acupuncture Points; Acupuncture Therapy; Adult; Electroacupuncture; Humans; Laser Therapy; Prospective Studies; Randomized Controlled Trials as Topic; Treatment Outcome; Wounds and Injuries; therapy
UT PubMed:34967368
PM 34967368
DA 2021-12-31
ER

PT J
AU Wang, JY
   Xu, L
   Zhang, RX
   Lao, L
AF Wang, Ju-yong
   Xu, Ling
   Zhang, Rui-xin
   Lao, Lixing
TI [Traditional Chinese medicine for cancer pain].
SO Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
LA chi
DT Review
AB Pain is one of the common symptoms of cancer which seriously affects the quality 
   of life of the patients. Cancer pain is mainly treated with the three-step 
   method, biological therapy or nerve block therapy based on antitumor therapy. 
   However, up to 50 percent of patients with cancer-related pain do not receive 
   adequate pain relief, affecting their physical and psychological well-being, and 
   leading to a lower quality of life for the patient after conventional treatment. 
   Clinical observation suggests that traditional Chinese medicine may alleviate 
   cancer-related pain either by oral administration, topical administration, 
   acupuncture or other means with continuing non-addictive and non-drug-resistant 
   qualities. However, scientific evaluation of the efficacy of herbs in the 
   treatment of pain is insufficient; the underlying mechanisms are unclear and, 
   safety and toxicity remain a concern.
C1 Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
NR 0
TC 0
SN 
EI 1672-197
J9 Zhong Xi Yi Jie He Xue Bao
PD FEB 4
PY 2011
VL 9
IS 2
BP 129
EP 34
DI 10.3736/jcim20110202 
PG -95
WC Drugs, Chinese Herbal; therapeutic use; Humans; Medicine, Chinese Traditional; Neoplasms; complications; Pain; drug therapy
UT PubMed:21288445
PM 21288445
DA 2011-02-04
ER

PT J
AU Bell, BK
   Cha, J
   Cavanaugh, KA
   O'Riordan, DL
   Rabow, MW
   Yang, AK
   Patel, S
   Park, SH
   McGrath, MK
   Whitaker, EM
   Nouri, SS
   Cheng, SW
AF Bell, Brieze K
   Cha, Jaeyoon
   Cavanaugh, Kathleen A
   O'Riordan, David L
   Rabow, Michael W
   Yang, Adrienne K
   Patel, Sohil
   Park, Sa Heen
   McGrath, Megan K
   Whitaker, Evans M
   Nouri, Sarah S
   Cheng, Stephanie W
TI Integrative Management of Cancer Pain: A Scoping Review of the Literature.
SO Cancer medicine
LA English
DT Journal Article
DE acupuncture; cancer pain; complementary and alternative medicine; integrative health; integrative medicine; integrative oncology; mindfulness
AB BACKGROUND: Cancer-related pain is common and debilitating. Patients frequently 
   use integrative medicine therapies to manage this, though safety and efficacy 
   evidence is incomplete. This scoping review aims to characterize the state of 
   integrative cancer pain therapy (ICPT) and identify priorities for future 
   research. METHODS: Following PRISMA guidelines, we searched PubMed, Embase, Web 
   of Science, PsycINFO, CINAHL, and Cochrane for ICPT studies published between 
   January 1, 1975 and May 26, 2022. Study findings were extracted and analyzed 
   using descriptive statistics and thematic analysis. Interventions were 
   categorized as follows: Whole Systems of Medicine (WSM); Mind-body Medicine 
   (MBM); Botanicals and Supplements (BAS); and Manual Therapies (MT). Quality 
   appraisal was performed using the Downs and Black checklist. Efficacy was 
   "positive" if there were statistically significant differences between study arms 
   (p < 0.05) favoring ICPT. RESULTS: Among 1246 studies reviewed, 151 met inclusion 
   criteria; 63.5% were excellent or good quality, and 68.9% were RCTs; 122 studies 
   (80.7%) were published since 2010. Studies occurred in 24 countries, in variable 
   settings, among participants with a wide range of cancers, disease status, and 
   age ranges. Studies investigating WSM and MBM interventions were most frequent 
   (35.7% for each), MT (20.59%), and BAS (7.9%). Overall, of the included studies, 
   127 (84.1%) found that the ICPT intervention reduced pain. CONCLUSIONS: Studies 
   on ICPT are increasingly common, and the majority of ICPT interventions 
   demonstrated a positive impact on cancer pain. Future rigorous research should 
   compare efficacy across integrative and biomedical interventions and explore how 
   to incorporate evidence-based ICPT into standard cancer treatment.
C1 University of California San Francisco, San Francisco, California, USA.
   Harvard Medical School, Boston, Massachusetts, USA.
   University of California San Francisco, San Francisco, California, USA.
   University of California San Francisco, San Francisco, California, USA.
   University of California San Francisco, San Francisco, California, USA.
   The MERI Center for Education in Palliative Care, Supported by the Mount Zion 
   University of California San Francisco, San Francisco, California, USA.
   University of California San Francisco, San Francisco, California, USA.
   University of California San Francisco, San Francisco, California, USA.
   University of California San Francisco, San Francisco, California, USA.
   Stanford University School of Medicine, Palo Alto, California, USA.
   University of California San Francisco, San Francisco, California, USA.
   University of California San Francisco, San Francisco, California, USA.
NR 0
TC 0
SN 2045-763
EI 
J9 Cancer Med
PD MAY 3
PY 2025
VL 14
IS 9
BP e70833
EP e70833
DI 10.1002/cam4.70833 
PG 1
WC Humans; Cancer Pain; therapy; Pain Management; methods; Integrative Medicine; methods; Mind-Body Therapies; methods; Complementary Therapies; methods; Neoplasms; complications
UT PubMed:40317896
PM 40317896
DA 2025-05-03
ER

PT J
AU Li, K
   Giustini, D
   Seely, D
AF Li, K
   Giustini, D
   Seely, D
TI A systematic review of acupuncture for chemotherapy-induced peripheral 
SO Current oncology (Toronto, Ont.)
LA English
DT Journal Article
DE Acupuncture; chemotherapy-induced peripheral neuropathy; cipn; integrative oncology; systematic reviews
AB OBJECTIVES: In cancer patients, chemotherapy-induced peripheral neuropathy (cipn) 
   is a common complication, characterized by pain, loss of sensation, and numbness. 
   Medical treatment for peripheral neuropathies has been shown to be ineffective 
   for cipn. Acupuncture has been shown to be safe and effective in treating 
   cancer-related symptoms and other peripheral neuropathies. For the present 
   review, we aimed to evaluate the efficacy of acupuncture for the treatment of 
   cipn. DESIGN: Comprehensive searches for relevant studies were conducted in Ovid 
   embase, the Web of Science, Ovid medline, the Cochrane Central Register of 
   Controlled Trials (central), cinahl (ebsco Information Services, Ipswich, MA, 
   U.S.A.), and the ClinicalTrials.gov Web site. References from previous systematic 
   reviews were also searched. Additional trials were found in the reference lists 
   of relevant papers and in searches of Google Scholar and acupuncture-specific Web 
   sites. Included studies were randomized controlled trials (rcts) of any type of 
   acupuncture used to treat patients with cipn. RESULTS: Three clinical trials (203 
   participants) were included. Two studies found acupuncture to be effective in 
   alleviating cipn pain and improving quality of life. One study found no benefit 
   in improving neuropathic pain, symptoms, or quality of life. Study quality was 
   variable and included a moderate overall risk of bias. CONCLUSIONS: The evidence 
   is insufficient to recommend acupuncture for the treatment or prevention of cipn. 
   Further research is needed to evaluate the effects of acupuncture in the 
   treatment of cipn. Given that acupuncture is considered safe and might provide 
   relief for patients, it can be considered at the clinician's discretion.
C1 Faculty of Medicine, University of British Columbia, Vancouver, BC.
   Biomedical Branch Library, University of British Columbia, Vancouver, BC.
   Ottawa Integrative Cancer Centre, Ottawa, ON.
NR 0
TC 0
SN 1718-772
EI 1198-005
J9 Curr Oncol
PD MAY 3
PY 2019
VL 26
IS 2
BP e147
EP e154
DI 10.3747/co.26.4261 
PG 1
WC Acupuncture Therapy; Antineoplastic Agents; adverse effects; Humans; Peripheral Nervous System Diseases; chemically induced; Randomized Controlled Trials as Topic
UT PubMed:31043820
PM 31043820
DA 2019-05-03
ER

PT J
AU Park, JW
   Jeon, JH
   Yoon, J
   Jung, TY
   Kwon, KR
   Cho, CK
   Lee, YW
   Sagar, S
   Wong, R
   Yoo, HS
AF Park, Jae-Woo
   Jeon, Ju-Hyun
   Yoon, Jeungwon
   Jung, Tae-Young
   Kwon, Ki-Rok
   Cho, Chong-Kwan
   Lee, Yeon-Weol
   Sagar, Stephen
   Wong, Raimond
   Yoo, Hwa-Seung
TI Effects of sweet bee venom pharmacopuncture treatment for chemotherapy-induced 
SO Integrative cancer therapies
LA English
DT Journal Article
AB OBJECTIVE: This is a case series reporting safety and degree of response to 1 
   dose level of sweet bee venom pharmacopuncture (SBVP) or melittin as a 
   symptom-control therapy for chemotherapy-induced peripheral neuropathy (CIPN). 
   SETTING: All treatments were conducted at the East West Cancer Center (EWCC), 
   Dunsan Oriental Hospital, Daejeon University, Republic of Korea, an institution 
   that uses complementary therapies for cancer patients. METHODS: Five consecutive 
   patients with CIPN were referred to the EWCC from March 20, 2010, to April 10, 
   2010. Patients with World Health Organization Chemotherapy-Induced Peripheral 
   Neuropathy (WHO CIPN) grade 2 or more were treated with SBVP for 3 treatment 
   sessions over a 1-week period. Measures of efficacy and safety. Validated Visual 
   Analog System (VAS) pain scale, WHO CIPN grade, and Functional Assessment of 
   Cancer Therapy-General (FACT-G) were compared before and after the 1-week course 
   of treatment. To ensure the safety of SBVP, pretreatment skin response tests were 
   given to patients to avoid any potential anaphylactic adverse effects. All 
   patients were closely examined for any allergenic responses following each 
   treatment session. RESULTS: One patient discontinued treatment after the first 
   session, and 4 patients completed all treatment sessions. Using each patient as 
   their own comparator, marked improvements of VAS, WHO CIPN grade, and physical 
   section scores of FACT-G were seen in 3 patients. Most important, there were no 
   related adverse side effects found. CONCLUSION: This safety results of the SBVP 
   therapy merits further investigations in a larger size trial for it to develop 
   into a potential intervention for managing CIPN symptoms. This study will be 
   extended to a dose-response evaluation to further establish safety and response, 
   prior to a randomized trial.
C1 Daejeon University, Daejeon, Korea.
NR 0
TC 0
SN 1552-695
EI 
J9 Integr Cancer Ther
PD JUL 1
PY 2011
VL 11
IS 2
BP 166
EP 71
DI 10.1177/1534735411413265 
PG -95
WC Acupuncture Therapy; adverse effects; Antineoplastic Agents; adverse effects; Bee Venoms; administration & dosage; Female; Humans; Melitten; administration & dosage; Middle Aged; Neoplasms; drug therapy; Pain Measurement; methods; Peripheral Nervous System Diseases; chemically induced; Prospective Studies; Republic of Korea
UT PubMed:21715371
PM 21715371
DA 2011-07-01
ER

PT J
AU Yu, JM
   Qu, PS
   Fan, H
   Wang, Z
   Jin, YB
   Tao, F
AF Yu, Jian-ming
   Qu, Pi-sheng
   Fan, Hao
   Wang, Zhen
   Jin, Ya-bei
   Tao, Fan
TI [Observation on the analgesic effect of transcutaneous electrical acupoint 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
AB OBJECTIVE: To observe the analgesic effect of transcutaneous electrical acupoint 
   stimulation (TEAS) in assisting general anesthesia (GA) for radical operation of 
   breast carcinoma so as to explore its clinical application value. METHODS: Sixty 
   patients scheduled for radical operations of the breast carcinoma were randomly 
   and equally divided into GA group and TEAS+ GA group. For GA, Propofol [4.5 
   microg/mL, target concentration; (3.0 +/- 0.5) microg/mL during operation] was 
   used in combination with Sufentanil (0.25 microg/kg) and Cis-atracurium amine 
   (0.2 mg/kg). TEAS (5-10 mA, 2 Hz/100 Hz) was applied to Hegu (LI 4)-Laogong (PC 
   8) and Neiguan (PC 6)-Waiguan (SJ 5) on the affected side of the body for 30 min. 
   Heart rate (HR), mean aterial pressure (MAP), tube removing time and 
   postoperative complications were recorded. Plasma beta-endorphin content was 
   assayed by radioimmunoassay. RESULTS: After anesthesia, patients with reduction 
   in MAP in GA group were significantly more than those in TEAS+GA group (P < 
   0.05), and their HR decreased remarkably (P < 0.05). After tracheal intubation, 
   MAP in TEAS+GA group kept relatively stable, which was superior to that of GA 
   group (P < 0.05). In comparison with GA group, the patients' analepsia time and 
   tube withdrawal time of TEAS+ GA group were significantly shorter; and the dosage 
   of analgesics of TEAS+GA group was significantly smaller than that of GA group (P 
   < 0.05). Patients with complications of pain, restlessness, drowsiness, nausea 
   and vomitting were obviously fewer in TEAS + GA group than those in GA group. 
   Compared with GA group, plasma beta-endorphin content in TEAS+GA group increased 
   considerably 30 min after TEAS, 5 min after skin-incision and after operation (P 
   < 0.05). CONCLUSION: TEAS combined with general anesthesia for breast radical 
   carcinoma operation can help keep a stable blood pressure during surgery, reduce 
   the dosage of analgesics and strengthen pain relief. The analgesic effect of TEAS 
   may be related to its effect in up-regulating plasma beta-endorphin level.
C1 Medicine Hospital of Zhejiang, Hangzhou 310003, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD MAY 13
PY 2010
VL 35
IS 1
BP 43
EP 6
DI 
PG -37
WC Acupuncture Points; Adult; Aged; Anesthesia; Breast Neoplasms; surgery; Carcinoma; surgery; Female; Humans; Middle Aged; Pain Management; Transcutaneous Electric Nerve Stimulation; Young Adult
UT PubMed:20458906
PM 20458906
DA 2010-05-13
ER

PT J
AU Yoon, J
   Jeon, JH
   Lee, YW
   Cho, CK
   Kwon, KR
   Shin, JE
   Sagar, S
   Wong, R
   Yoo, HS
AF Yoon, Jeungwon
   Jeon, Ju-Hyun
   Lee, Yeon-Weol
   Cho, Chong-Kwan
   Kwon, Ki-Rok
   Shin, Ji-Eun
   Sagar, Stephen
   Wong, Raimond
   Yoo, Hwa-Seung
TI Sweet bee venom pharmacopuncture for chemotherapy-induced peripheral neuropathy.
SO Journal of acupuncture and meridian studies
LA English
DT Journal Article
AB INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is sensory and 
   motor nerve damage to the peripheral nervous system caused by chemotherapeutic 
   agents. It often causes pain and other varying degrees of neuropathic symptoms 
   accompanied by functional limitations and reduced quality of life. Currently, 
   there is no standard treatment protocol for the treatment of CIPN. OBJECTIVE: In 
   need of more research to develop new therapeutic options focusing on their 
   safety, efficacy, and long-term sustained clinical effects, a pilot study of 
   sweet bee venom pharmacopuncture (SBVP) for CIPN was conducted to build up 
   preliminary efficacy data in the process of preparing for a future larger scale 
   randomized controlled SBVP trial for CIPN. METHODS: We conducted a prospective 
   case series by analyzing the clinical observations made of CIPN patients treated 
   with SBVP. A total of 11 eligible consecutive CIPN patients who visited East-West 
   Cancer Center from June 1, 2010, to February 28, 2011, were treated with total of 
   six SBVP treatments given within the 3-week period. The outcomes were measured 
   using World Health Organization Common Toxicity Criteria for Peripheral 
   neuropathy (WHO grading system), Patient Neurotoxicity Questionnaire (PNQ), 
   Visual Analogue System (VAS), and Health-Related Quality of Life (HRQOL) 
   collected at the baseline, post-second, fourth, and the final treatment. Patients 
   were followed 3 weeks into no intervention to determine the sustained effects of 
   pharmacopuncture. RESULTS: Both of the WHO CIPN grade and PNQ scores have shown a 
   decrease in the level of neuropathy. VAS pain level has also shown a great 
   decrease and improvement in patients' quality of life have also been detected 
   though modest. Changes in WHO grade, VAS and Total HRQOL scores between the 
   baseline and after the last treatment session were significant. Changes in WHO 
   grade, Total PNQ, PNQ-sensory, VAS, Total HRQOL, and HRQOL-functional scores 
   between the baseline and the 3-week follow-up were significant. CONCLUSION: The 
   positive result of the study supports the potential value of conducting a fully 
   powered trial to explore further efficacy of SBVP for CIPN. However a single 
   positive result within this pilot study must be interpreted with caution.
C1 East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University, Daejeon, Korea.
NR 0
TC 0
SN 2093-815
EI 
J9 J Acupunct Meridian Stud
PD AUG 18
PY 2012
VL 5
IS 4
BP 156
EP 65
DI 10.1016/j.jams.2012.05.003 
PG -91
WC Acupuncture Points; Adult; Bee Venoms; administration & dosage; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasms; drug therapy; Peripheral Nervous System Diseases; drug therapy; Pilot Projects; Prospective Studies
UT PubMed:22898064
PM 22898064
DA 2012-08-18
ER

PT J
AU Choi, HS
   Lee, SH
   Lee, YJ
   Ha, IH
AF Choi, Hee-Seung
   Lee, Sook-Hyun
   Lee, Yoon Jae
   Ha, In-Hyuk
TI Nonsurgical integrative Korean Medicine treatment of discal cyst: A case report 
SO Medicine
LA English
DT Journal Article
AB RATIONALE: Discal cysts are rare lesions characterized by pain caused by 
   neurogenic compression with similar symptoms as those of disc herniation. This 
   study aims to report the spontaneous regression of discal cyst achieved through 
   nonsurgical integrative Korean Medicine treatment and the clinical 
   epidemiological features of discal cyst cases collected from 4 institutions. 
   PATIENT CONCERNS: A 31-year-old woman had low back pain and radiating pain 
   equivalent to a numeral rating scale (NRS) of 8 and had limitations in daily work 
   and activities. DIAGNOSES: The patient was diagnosed as having discal cysts that 
   compressed the left S1 based on findings of L-spine magnetic resonance imaging 
   (MRI) performed at our hospital. INTERVENTIONS: The patient received nonsurgical 
   Korean Medicine treatment and after 24 days of treatment in the hospital, she 
   underwent 16 additional treatments as an outpatient. OUTCOMES: Spontaneous 
   regression was confirmed in the L-spine MRI follow-up at 36 days and 99 days 
   after the initial test, and the patient underwent once-a-week follow up to 
   examine NRS, Oswestry Disability Index (ODI), EuroQol-5 Dimensions (EQ-5D), and 
   fear-avoidance beliefs questionnaire (FABQ) after 4 weeks, and 2, 3, and 6-month 
   follow-ups after that. The patient was discharged in a painless condition, and 
   she was able to carry on for 5 months without increased pain. LESSONS: Discal 
   cysts are more rapid progress than disc herniation, it seems valid to attempt 
   nonsurgical treatment. Epidemiologically, this is the first study to present the 
   clinical epidemiological characteristics of discal cysts, it would provide 
   valuable information to clinicians who treat and study discal cysts.
C1 Jaseng Hospital of Korean Medicine.
   Department of Medical Science of Meridian, Graduate School, Kyung Hee University.
   Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea.
   Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea.
   Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JUL 7
PY 2019
VL 98
IS 27
BP e16189
EP e16189
DI 10.1097/MD.0000000000016189 
PG 1
WC Acupuncture Therapy; Adult; Cysts; therapy; Female; Humans; Integrative Medicine; Lumbar Vertebrae; diagnostic imaging; Magnetic Resonance Imaging; Male; Medicine, East Asian Traditional; methods; Middle Aged; Pain Measurement; Physical Therapy Modalities; Republic of Korea; Retrospective Studies; Treatment Outcome
UT PubMed:31277125
PM 31277125
DA 2019-07-07
ER

PT J
AU Olson, EA
   Metzger, AK
   Mallory, MJ
   Mackey, RM
AF Olson, Emily A
   Metzger, Abbey K
   Mallory, Molly J
   Mackey, Regina M
TI Opioid-Induced Constipation and Acupuncture: A Case Discussion.
SO Journal of pain and symptom management
LA English
DT Journal Article
DE Acupuncture; cancer; opioid; opioid-induced constipation; palliative medicine
AB BACKGROUND: Use of acupuncture for treatment of functional constipation is well 
   studied; however, studies examining use of acupuncture for opioid-induced 
   constipation are limited. CASE DESCRIPTION: A 70-year-old woman with newly 
   diagnosed multiple myeloma discovered after presentation to the emergency room 
   with severe back pain. Pain management required use of opioids, escalating to 
   effect. Hospital course was complicated by opioid-induced constipation causing 
   abdominal pain, nausea, and ileus despite aggressive titration of stimulant and 
   osmotic laxatives as well as administration of suppositories and enemas on 
   multiple occasions. Prior to nasogastric tube placement for the ileus, the 
   patient requested acupuncture treatment in attempt to relieve constipation. 
   Shortly after acupuncture session, patient passed multiple stools with 
   improvement in abdominal pain and nausea and avoidance of nasogastric tube. 
   CONCLUSION: Acupuncture for opioid-induced constipation may provide symptom 
   relief through use of nonpharmacologic interventions; however, further studies 
   are needed to determine the optimal therapeutic approach.
C1 General Internal Medicine, Center for Palliative Medicine, Mayo Clinic, Rochester, Minnesota. 
   General Internal Medicine, Center for Palliative Medicine, Mayo Clinic, Rochester, Minnesota.
   General Internal Medicine, Integrative Medicine and Health, Mayo Clinic, Rochester, Minnesota.
   General Internal Medicine, Center for Palliative Medicine, Mayo Clinic, Rochester, Minnesota.
EM Olson.emily3@mayo.edu
NR 0
TC 0
SN 1873-651
EI 
J9 J Pain Symptom Manage
PD FEB 9
PY 2021
VL 62
IS 4
BP 876
EP 880
DI 10.1016/j.jpainsymman.2021.01.135 
PG 4
WC Acupuncture Therapy; adverse effects; Aged; Analgesics, Opioid; adverse effects; Constipation; chemically induced; Female; Humans; Laxatives; therapeutic use; Opioid-Induced Constipation
UT PubMed:33556492
PM 33556492
DA 2021-02-09
ER

PT J
AU He, C
   Wang, T
   Gu, Y
   Tian, Q
   Zhou, B
   Wu, C
AF He, Chengjian
   Wang, Tao
   Gu, Yifeng
   Tian, Qinghua
   Zhou, Bi
   Wu, Chungen
TI Unusual case of pyogenic spondylodiscitis, vertebral osteomyelitis and bilateral 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE INFECTIOUS DISEASES; PAIN MANAGEMENT
AB BACKGROUND: We report, for the first time, a case of pyogenic spondylodiscitis 
   combined with vertebral osteomyelitis and bilateral psoas abscesses after 
   acupuncture. CASE HISTORY: A 60-year-old man was diagnosed with rectal cancer, 
   and radical rectectomy and permanent colostomy were carried out. However, 3 years 
   after the surgery the patient complained of pain in the lower back, and the 
   symptoms worsened after seven sessions of acupuncture. Technetium 99m-labelled 
   methylene diphosphonate ((99m)Tc-MDP) bone scintigraphy (BS) revealed abnormal 
   uptake of (99m)Tc-MDP in the L4 and L5 vertebrae. He was admitted to our hospital 
   because of suspected bone metastases from rectal cancer. He was diagnosed with 
   infection based on a history of acupuncture and the findings of enhanced MRI and 
   CT. Percutaneous lumbar discectomy (PLD), external drainage and irrigation using 
   antibiotics were carried out to treat the L4-5 disc. Pathological analyses and 
   bacterial culture of the resected disc confirmed infection with group C 
   streptococcus. Postoperative antibiotic treatment resulted in significant pain 
   relief on the third day and gradual complete relief. Considerable improvement was 
   seen on CT and MRI at follow-up. CONCLUSIONS: We consider it highly likely that 
   this patient's infection was caused by acupuncture. In patients with malignancy, 
   abnormal uptake of (99m)Tc-MDP in BS may signify bone metastasis but can also be 
   observed in bone infections. PLD can be used to resect diseased discs to relieve 
   pain quickly and to prevent herniation of lumbar discs. After PLD, external 
   drainage can be employed for abscess drainage, decompression and perfusion of 
   antibiotics. PLD may serve as an alternative to open surgery for pyogenic 
   spondylodiscitis.
C1 Department of Diagnostic and Interventional Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
   Department of Diagnostic and Interventional Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
   Department of Diagnostic and Interventional Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
   Department of Diagnostic and Interventional Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
   Department of Diagnostic and Interventional Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
   Department of Diagnostic and Interventional Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD MAR 22
PY 2015
VL 33
IS 2
BP 154
EP 7
DI 10.1136/acupmed-2014-010717 
PG -147
WC Acupuncture Therapy; adverse effects; Discitis; diagnostic imaging; Humans; Lumbar Vertebrae; diagnostic imaging; Male; Middle Aged; Osteomyelitis; diagnostic imaging; Psoas Abscess; diagnostic imaging; Radiography; Tomography, Emission-Computed
UT PubMed:25795295
PM 25795295
DA 2015-03-22
ER

PT J
AU Chen, J
   Liu, Q
   Xiong, J
   Lu, L
   Zhu, S
   Zhong, Z
   Tang, G
   Zhou, X
   Guo, H
   Chen, Z
AF Chen, Jun
   Liu, Qifang
   Xiong, Jun
   Lu, Lunbin
   Zhu, Siyuan
   Zhong, Zhiying
   Tang, Genhua
   Zhou, Xingchen
   Guo, Han
   Chen, Zhijun
TI Effect of fire needle for ganglion cysts: A protocol of systematic review and 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Ganglion cysts (GCs) are tumor-like lesions that often occur in the 
   soft tissues, which are mostly caused by the degeneration of mucin produced by 
   the joint capsule and tendon sheath on the carpal dorsal joints of extremities. 
   GCs may appear asymptomatic as benign tumors, but some patients also seek 
   treatment because of the pain caused by these fluid-filled cysts. As a kind of 
   complementary and alternative therapy, there have been some studies published in 
   China which have proved that the fire needle has a better therapeutic effect on 
   ganglion cyst. The purpose of this systematic review is to evaluate the efficacy 
   of fire needle in the treatment of GCs. METHODS: PubMed, EMBASE, the Cochrane 
   Library, Chinese National Knowledge Infrastructure, Chinese VIP Information, 
   Wanfang Database, and Chinese Biomedical Literature Database were searched by 2 
   reviewers from the inception until August 2020. The original study that 
   randomised control trials of fire needle for GCs will be selected and is not 
   limited by country or language. In addition, researches in progress, the 
   reference lists and the citation lists of identified publications will be 
   retrieved similarly. Study selection, data extraction, and assessment of the 
   quality will be performed independently by 2 reviewers who have been trained 
   prior to data extraction. A meta-analysis will be conduct if the quantity and 
   quality of the original studies included are satisfactory; otherwise, a 
   descriptive analysis will be conducted. Review Manager V5.4: (The Nordic Cochrane 
   Centre, The Cochrane Collaboration, Copenhagen, Denmark) software will be using 
   for data synthesis and assessment the risk of bias according by Cochrane 
   Handbook. RESULT: This study will provide a comprehensive review of current 
   evidence for the treatment of fire needle on GCs. CONCLUSION: The conclusion of 
   this study will provide a judging basis that whether the treatment of GCs with 
   fire needle is effective. INPLASY REGISTRATION NUMBER: INPLASY202080032.
C1 Jiangxi University of Traditional Chinese Medicine.
   Nanchang First Hospital.
   The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
   Jiangxi University of Traditional Chinese Medicine.
   Jiangxi University of Traditional Chinese Medicine.
   Jiangxi University of Traditional Chinese Medicine.
   Jiangxi University of Traditional Chinese Medicine.
   The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
   The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
   The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD OCT 9
PY 2020
VL 99
IS 41
BP e22602
EP e22602
DI 10.1097/MD.0000000000022602 
PG 1
WC Acupuncture Therapy; Ganglion Cysts; therapy; Humans; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; Systematic Reviews as Topic
UT PubMed:33031314
PM 33031314
DA 2020-10-09
ER

PT J
AU Asmussen, S
   Przkora, R
   Maybauer, DM
   Fraser, JF
   Sanfilippo, F
   Jennings, K
   Adamzik, M
   Maybauer, MO
AF Asmussen, Sven
   Przkora, Rene
   Maybauer, Dirk M
   Fraser, John F
   Sanfilippo, Filippo
   Jennings, Kristofer
   Adamzik, Michael
   Maybauer, Marc O
TI Meta-Analysis of Electroacupuncture in Cardiac Anesthesia and Intensive Care.
SO Journal of intensive care medicine
LA English
DT Journal Article
DE anesthetic drugs; cytokines; immune response; systematic review; transcutaneous electrical acupoint stimulation
AB BACKGROUND: Acupuncture treatment has been employed in China for over 2500 years 
   and it is used worldwide as analgesia in acute and chronic pain. Acupuncture is 
   also used in general anesthesia (GA). The aim of this systematic review and 
   meta-analysis was to assess the efficacy of electroacupuncture (EA) in addition 
   to GA in patients undergoing cardiac surgery. METHODS: We searched 3 databases 
   (Pubmed, Cochrane Library, and Web of Science-from 1965 until January 31, 2017) 
   for randomized controlled trials (RCTs) including patients undergoing cardiac 
   surgery and receiving GA alone or GA + EA. As primary outcomes, we investigated 
   the association between GA + EA approach and the dosage of intraoperative 
   anesthetic drugs administered, the duration of mechanical ventilation (MV), the 
   postoperative dose of vasoactive drugs, the length of intensive care unit (ICU) 
   and hospital stay, and the levels of troponin I and cytokines. RESULTS: The 
   initial search yielded 477 citations, but only 7 prospective RCTs enrolling a 
   total of 321 patients were included. The use of GA + EA reduced the dosage of 
   intraoperative anesthetic drugs (P < .05), leading to shorter MV time (P < .01) 
   and ICU stay (P < .05) as well as reduced postoperative dose of vasoactive drugs 
   (P < .001). In addition, significantly lower levels of troponin I (P < .01) and 
   tumor necrosis factor α (P < .01) were observed. CONCLUSION: The complementary 
   use of EA for open-heart surgery reduces the duration of MV and ICU stay, blunts 
   the inflammatory response, and might have protective effects on the heart. Our 
   findings stimulate future RCT to provide definitive recommendations.
C1 1 Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.
   2 Departments of Anesthesiology and Epidemiology and Biostatistics, The 
   3 Critical Care Research Group, Prince Charles Hospital, The University of Queensland, Brisbane, Queensland, Australia.
   2 Departments of Anesthesiology and Epidemiology and Biostatistics, The University of Texas Medical Branch, Galveston, TX, USA.
   4 Department of Anesthesiology, College of Medicine, University of Florida, 
   2 Departments of Anesthesiology and Epidemiology and Biostatistics, The University of Texas Medical Branch, Galveston, TX, USA.
   5 Department of Cardiothoracic Anaesthesia and Critical Care, St George's 
   3 Critical Care Research Group, Prince Charles Hospital, The University of Queensland, Brisbane, Queensland, Australia.
   6 Department of Anesthesia and Intensive Care, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy.
   7 Department of Anaesthesiology and Intensive Care, Philipps University, Marburg, 
   2 Departments of Anesthesiology and Epidemiology and Biostatistics, The University of Texas Medical Branch, Galveston, TX, USA.
   1 Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.
   2 Departments of Anesthesiology and Epidemiology and Biostatistics, The University of Texas Medical Branch, Galveston, TX, USA.
   3 Critical Care Research Group, Prince Charles Hospital, The University of 
   5 Department of Cardiothoracic Anaesthesia and Critical Care, St George's Hospital, London, UK.
   8 Cardiothoracic Anaesthesia and Intensive Care, Central Manchester University 
NR 0
TC 0
SN 1525-148
EI 
J9 J Intensive Care Med
PD JUN 2
PY 2017
VL 34
IS 8
BP 652
EP 661
DI 10.1177/0885066617708558 
PG 9
WC Anesthesia, Cardiac Procedures; methods; Anesthesia, General; Cardiac Surgical Procedures; Critical Care; Electroacupuncture; Humans; Outcome Assessment, Health Care; Perioperative Care; methods
UT PubMed:28569130
PM 28569130
DA 2017-06-02
ER

PT J
AU Hou, L
   Xu, L
   Shi, Y
   Gu, F
AF Hou, Lili
   Xu, Lei
   Shi, Yan
   Gu, Fen
TI Effect of electric acupoint stimulation on gastrointestinal hormones and motility 
SO Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
LA English
DT Journal Article
AB OBJECTIVE: To evaluate the effects of electric acupoint stimulation on 
   gastrointestinal hormones and motility among geriatric postoperative patients 
   with gastrointestinal tumors, and to explore an efficient and noninvasive method 
   for postoperative recovery of bowel functions. METHODS: Forty patients were 
   randomly and evenly assigned into a regular nursing care group (RNC) and an 
   acupoint electric stimulation group (AES). Patients in the RNC group received 
   regular nursing care and patients in the AES group received regular nursing care 
   plus electric stimulation of acupoints. The serum levels of gastrin (GAS), 
   motilin (MOT), and cholecystokinin (CCK), and an electrogastrogram (EGG) of all 
   the patients were evaluated on the first, third, and fifth day after surgery. The 
   time to first flatus after surgery and the number of patients with side effects 
   such as abdominal pain, abdominal distention, and diarrhea were recorded. 
   RESULTS: There were significant differences between the two groups in GAS, MOT, 
   EGG, time to first flatus, abdominal pain, abdominal distention, and diarrhea (P 
   < 0.05). CONCLUSION: Electric stimulation on acupoints could increase levels of 
   GAS and MOT, promote the recovery of gastrointestinal functions, and decrease 
   complications among postoperative senile patients with gastrointestinal tumors.
NR 0
TC 0
SN 2589-451
EI 
J9 J Tradit Chin Med
PD MAY 2
PY 2017
VL 36
IS 4
BP 450
EP 5
DI 10.1016/s0254-6272(16)30061-9 
PG -445
WC Acupuncture Points; Aged; Aged, 80 and over; Electric Stimulation; Female; Gastrointestinal Diseases; etiology; Gastrointestinal Hormones; metabolism; Gastrointestinal Motility; Gastrointestinal Neoplasms; complications; Humans; Male; Middle Aged; Postoperative Complications; etiology
UT PubMed:28459508
PM 28459508
DA 2017-05-02
ER

PT J
AU Sun, ZR
   Lü, XL
   Yin, HN
   Hao, JS
   Zeng, XX
   Li, ZX
AF Sun, Zhong-Ren
   Lü, Xiao-Lin
   Yin, Hong-Na
   Hao, Ji-Shun
   Zeng, Xiang-Xin
   Li, Zhu-Xin
TI [Progress of Researches on Mechanisms of Acupuncture Therapy in Regulating Brain 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Review
DE Acupuncture; Brain plasticity; Mechanism research; Protein expression
AB Brain plasticity is referred to the ability of the brain to change in structure 
   and functional activities from microscopic aspects (synapses) in individual 
   neurons to larger-scale aspects such as cortical remapping, neuronal remodeling, 
   etc. in response to injury. Acupuncture has a positive effect in the treatment of 
   cerebral diseases, thus leading to an increasing research on its underlying 
   mechanisms in regulating brain plasticity. The present paper reviewed recent 
   development of studies on acupuncture treatment of Alzheimer's disease, vascular 
   dementia, cerebral ischemia, bone cancer pain, autism, etc. from 1) regulating 
   synaptic plasticity (up-regulating the proportion of hippocampal synapses, 
   increasing synaptic curvature, post-synaptic density, and numerical density, 
   areal density, and lowering synaptic cleft); 2) increasing hippocampal 
   post-synaptic potential slop, peak and peak area of population spikes to evoke 
   long-term potentiation (LTP) by regulating the expression of glutamate 
   N-methyl-D-aspartate (NMDA) and alpha 
   amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors, and growth 
   associated protein (GAP-43); 3) down-regulating the expression of glial 
   fibrillary acidic protein (GFAP) to suppress the activity of astrocytes in the 
   ischemic cerebral area and hippocampus in cerebral ischemia rats, and in the 
   spinal cord dorsal horns of bone cancer rats, etc. and promoting vimentin and 
   connexin 43 expression; and 4) promoting neuronal remodeling, and repair and 
   regeneration of the injured nerve in the central nervous system via regulating 
   neuron-glia network, expression of nerve growth factor, brain derived 
   neurotrophic factor, etc. The future studies should pay more attention to 1) the 
   contribution of acupuncture intervention to the correlation between the 
   initiation of the endogenous protective effect and the brain plasticity during 
   the onset of nerve injury and repair of the injured nerve, and 2) standarization 
   of stimulating quantity, manipulation and duration of acupuncture treatment, as 
   well as the relationship between the stimulating quantity and efficacy.
C1 Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China.
   The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150001.
   The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150001.
   American International Neural Acupuncture and Moxibustion Institution, New Mexico, USA.
   The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150001.
   Graduate School of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD OCT 27
PY 2018
VL 43
IS 10
BP 674
EP 7
DI 10.13702/j.1000-0607.170039 
PG -667
WC Acupuncture Therapy; Animals; Brain; Hippocampus; Humans; Neuronal Plasticity; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses
UT PubMed:30365266
PM 30365266
DA 2018-10-27
ER

PT J
AU Grushina, TI
   Konchugova, TV
   Kulchitskaya, DB
   Gushchina, NV
   Astakhova, KA
AF Grushina, T I
   Konchugova, T V
   Kulchitskaya, D B
   Gushchina, N V
   Astakhova, K A
TI [Rehabilitation methods for cancer patients with peripheral polyneuropathy 
SO Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury
LA rus
DT Review
DE chemotherapy; neuropathy; neurotoxicity; polyneuropathy; rehabilitation
AB An analytical review of the methods of cancer patients' rehabilitation with 
   peripheral polyneuropathy induced by cytostatics (PNPIC) was carried out. Studies 
   from electronic databases were investigated: Scopus, Web of Science, MedLine, 
   World Health Organization, The Cochrane Central Register of Controlled Trials, 
   ScienceDirect, US National Library of Medicine National Institutes of Health, 
   PubMed Cancer, eLIBRARY, CyberLeninka. Despite the improvement of anticancer 
   therapy and an increase in patients' life expectancy, the emerging peripheral 
   polyneuropathy remains an urgent problem, since it significantly affects both the 
   patients' life quality and the selection of adequate therapy. The frequency of 
   detection of PNPIC is 90%, after discontinuation of treatment; symptoms of 
   damaged peripheral nerve fibers remain in 30% of patients. The clinical symptoms 
   of PNPIC are varied and most often include numbness in the extremities and / or 
   increased sensitivity to thermal or mechanical stimuli, neuropathic pain. 
   Currently, to prevent PNPIC, treatment is being modified with a reduction in the 
   duration of courses and doses of cytostatics, and interruption of treatment. 
   Official guidelines do not recommend any prophylaxis other than the possible use 
   of duloxetine or a topical gel containing baclofen, amitriptyline, and ketamine. 
   Over the past few years, there has been no significant progress in the prevention 
   and treatment of PNPIC. The most common drug treatment method in clinical 
   practice is the prescription of vitamins B. Among the non-drug treatment methods 
   of PNPIC, the authors used acupuncture, electro-acupuncture, manual therapy, 
   massage, gymnastics, yoga, sensorimotor training, general vibration therapy, 
   percutaneous electro-neuro-stimulation, electro-analgesia, local cryotherapy, 
   hydrotherapy, low-intensity alternating magnetic radiation. The studies included 
   in the review are heterogeneous in design and protocol, number of patients, and 
   time points for assessing outcomes. In connection with the existing differences, 
   it is not possible to carry out a comparative analysis of the results of these 
   rehabilitation types and to give an unambiguous answer about their effectiveness. 
   As the analysis has shown, peripheral PNPIC is well known all over the world, 
   however, the search for methods of its treatment is far from complete.
C1 National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia.
   National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia.
   National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia.
   National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia.
   National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia.
NR 0
TC 0
SN 
EI 0042-878
J9 Vopr Kurortol Fizioter Lech Fiz Kult
PD FEB 20
PY 2021
VL 98
IS 1
BP 58
EP 63
DI 10.17116/kurort20219801158 
PG 5
WC Cytostatic Agents; Humans; Neoplasms; drug therapy; Neuralgia; Pain Management; Polyneuropathies; drug therapy
UT PubMed:33605131
PM 33605131
DA 2021-02-20
ER

PT J
AU Zhang, M
   Zhao, N
   He, JH
   Li, JL
AF Zhang, Meng
   Zhao, Nan
   He, Jin-Hua
   Li, Jian-Li
TI [Effects of transcutaneous electrical acupoint stimulation on the postoperative 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE after surgery; frail elderly; inflammatory factors; randomized controlled trial (RCT); sleep quality; transcutaneous electrical acupoint stimulation
AB OBJECTIVE: To observe the effects of transcutaneous acupoint stimulation (TEAS) 
   on sleep quality and inflammatory factor in frail elderly patients undergoing 
   laparoscopic colorectal cancer surgery. METHODS: A total of 100 frail elderly 
   patients undergoing elective laparoscopic colorectal cancer surgery were randomly 
   divided into an observation group and a control group, 50 cases in each one. 
   Patients in the observation group received TEAS, 30 min before surgery until the 
   end of surgery, at 18:00 on the day of surgery and on the 1st, 2nd and 3rd day 
   after surgery (30 min each time). TEAS was delivered at bilateral Neiguan (PC 6), 
   Shenmen (HT 7) and Hegu (LI 4). The disperse-dense wave of 2 Hz/100 Hz was 
   selected, and the maximal stimulation intensity depended on patient's tolerance. 
   The operation procedure in the control group was same as the observation group, 
   but without electric stimulation exerted. The 1st day before surgery and on the 
   1st, 3rd and 7th day after surgery, the scores of Pittsburgh sleep quality index 
   (PSQI) and Athens insomnia scale (AIS), as well as the serum levels of C reactive 
   protein (CRP) and interleukin-6 (IL-6) were observed in the patients of two 
   groups. At 24 h, 48 h and 72 h after surgery, the score of pain visual analogue 
   scale (VAS) was recorded in the two groups, as well as the pressing times of 
   analgesic pump and the usage of flurbiprofen axetil during analgesic stage. The 
   occurrence of post operative adverse reactions was observed in the patients of 
   two groups. RESULTS: On the 1st and 3rd day after surgery, except the usage of 
   hypnotic drug scores, the scores of each item and the total scores of PSQI, as 
   well as AIS scores were all increased in the two groups compared with those of 1 
   day before surgery (P<0.05); and the scores in the observation group were lower 
   than those in the control group (P<0.05). On the 7th day after surgery, the 
   scores of each item and the total scores of PSQI, and AIS scores were not 
   different statistically in comparison between the two groups (P>0.05). On the 
   1st, 3rd and 7th day after surgery, serum levels of CRP and IL-6 were all 
   increased in the patients of two groups when compared with those of 1 day before 
   surgery (P<0.05), serum levels CRP and IL-6 in the patients of the observation 
   group were lower than those of the control group (P<0.05). The VAS scores of 24 
   h, 48 h and 72 h after surgery, the pressing times of analgesic pump, the 
   frequency and dosage of the remedies were not different statistically between the 
   two groups (P>0.05). CONCLUSION: TEAS can effectively improve sleep quality and 
   reduce inflammatory reaction in frail elderly patients undergoing laparoscopic 
   colorectal cancer surgery.
C1 Department of Anesthesia, Hebei People's Hospital, Shijiazhuang 050051, China.
   Department of Anesthesia, Third Hospital of Hebei Medical University.
   Department of Anesthesia, Hebei People's Hospital, Shijiazhuang 050051, China.
   Department of Anesthesia, Hebei People's Hospital, Shijiazhuang 050051, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUL 11
PY 2023
VL 43
IS 7
BP 751
EP 5
DI 10.13703/j.0255-2930.20220919-k0002 
PG -746
WC Aged; Humans; Acupuncture Points; Frail Elderly; Interleukin-6; Sleep Quality; C-Reactive Protein; Colorectal Neoplasms
UT PubMed:37429652
PM 37429652
DA 2023-07-11
ER

PT J
AU Efverman, A
AF Efverman, Anna
TI Implementation of Acupuncture in Routine Oncology Care: A Comparison of 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; attitudes; evidence-based care; expectations; integrative medicine; integrative oncology; nursing; physiotherapy
AB BACKGROUND: It is important to investigate beliefs in acupuncture in 
   professionals because professionals' expectations may affect treatment outcomes. 
   AIM: To document the type, number, and education of professionals practicing 
   acupuncture. Further, to compare beliefs about the effectiveness of acupuncture 
   for common cancer related symptoms in the different types of professionals. 
   METHODS: This cross-sectional study employed a questionnaire on practice and 
   beliefs regarding acupuncture effects for symptoms that commonly occur in 
   patients treated within oncology care settings. The respondents (n = 555) 
   consisted of oncology professionals that is, physicians (n = 133), nurses 
   (n = 172), and physiotherapists (n = 117). Additional respondents consisted of 
   acupuncturists (n = 133), working outside approved health care. RESULTS: Of the 
   respondents, acupuncture was practiced by 4% of the physicians, 6% of the nurses, 
   58% of the physiotherapists, and 90% of the acupuncturists. The professionals 
   believed acupuncture to be effective for pain (of the physicians, nurses, 
   physiotherapists, and acupuncturists, 94%, 98%, 89%, and 99% respectively 
   believed in the effectiveness), chemotherapy-induced nausea (corresponding 
   figures: 74%, 89%, 89%, and 93%), and vasomotor symptoms (corresponding figures: 
   71%, 81%, 80%, and 97%). The physicians believed acupuncture to be effective in a 
   mean of 5 symptoms, nurses in 6 symptoms, physiotherapists in 6 symptoms, and 
   acupuncturists in 10 symptoms (P < .001). CONCLUSIONS: Since the professionals 
   varied substantially regarding practice, education and beliefs in acupuncture, 
   oncology clinics may consider delivering patient preferred acupuncture according 
   to evidence-informed guidelines rather than on varying preferences among the 
   professionals, since professionals' treatment expectations may modify treatment 
   outcomes.
C1 University of Gävle, Gävle, Sweden.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD NOV 19
PY 2022
VL 21
IS 
BP 15347354221132834
EP 15347354221132834
DI 10.1177/15347354221132834 
PG 1
WC Humans; Physical Therapists; Cross-Sectional Studies; Acupuncture Therapy; Physicians; Nurses
UT PubMed:36398874
PM 36398874
DA 2022-11-19
ER

PT J
AU Öztekin, C
   Öztekin, A
AF Öztekin, Coşkun
   Öztekin, Aynure
TI Global trends in acupuncture research: A scientometric analysis from 1980 to 
SO Medicine
LA English
DT Journal Article
AB The objective of this study was to examine articles on acupuncture from past to 
   present, revealing prevalent research trends, showcasing global productivity, 
   identifying international collaborations, and highlighting influential 
   publications and journals in the field. We acquired a comprehensive dataset 
   comprising 9340 articles pertaining to acupuncture that were published within the 
   time frame spanning from 1980 to 2023. These articles were sourced from the Web 
   of Science and underwent rigorous analysis through a diverse set of bibliometric 
   techniques. Our analytical approaches encompassed trend keyword analysis, 
   thematic evolution analysis, conceptual structure analysis, factor analysis, 
   citation and co-citation analyses, as well as an exploration of international 
   collaboration patterns. The 3 most productive countries were China (n = 3357), 
   the USA (n = 1351), and South Korea (n = 814). The 3 most productive journals 
   were Acupuncture in Medicine (n = 440), Evidence Based Complementary and 
   Alternative Medicine (n = 415), and Medical Acupuncture (n = 400). The 3 journals 
   with the highest h-index on acupuncture were the Journal of Alternative and 
   Complementary Medicine (h = 45), Pain (h = 41), and the American Journal of 
   Chinese Medicine (h = 35). The most active author was Park Hi-Joon (n = 128). 
   According to the findings of the factor analysis, acupuncture literature was 
   grouped around 3 main subfactors. The primary factor encompassed topics related 
   to the effectiveness/applicability of the treatment method for various medical 
   conditions and general principles of acupuncture methods and points. The second 
   factor covered topics related to mental health and quality of life. The third 
   subfactor addressed the qualitative and quantitative analysis direction of 
   acupuncture, such as meta-analysis and systematic reviews, and randomized 
   controlled trials. From the past to the present, the most extensively researched 
   main topics in acupuncture literature have covered a wide range of subjects. 
   Prominent themes among these topics included acupuncture methods and 
   applications, pain management, the nervous system and acupuncture, mental health 
   and acupuncture, quality of life, and general health. In recent years, emerging 
   trends in acupuncture research have focused on neurological health issues, 
   oncology and cancer treatment, women's health and hormonal issues, sleep 
   problems, digestive issues, and studies related to the quantitative and 
   qualitative evaluation of acupuncture research.
C1 Department of Family Medicine, Hitit University, Faculty of Medicine, Çorum, Turkey.
   Department of Dermatology, Hitit University, Faculty of Medicine, Çorum, Turkey.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD SEP 10
PY 2024
VL 103
IS 36
BP e39549
EP e39549
DI 10.1097/MD.0000000000039549 
PG 1
WC Bibliometrics; Humans; Acupuncture Therapy; trends; Biomedical Research; trends; Periodicals as Topic; trends; China; Republic of Korea
UT PubMed:39252270
PM 39252270
DA 2024-09-10
ER

PT J
AU Ma, Y
   Dong, M
   Zhou, K
   Mita, C
   Liu, J
   Wayne, PM
AF Ma, Yan
   Dong, Ming
   Zhou, Kehua
   Mita, Carol
   Liu, Jianping
   Wayne, Peter M
TI Publication Trends in Acupuncture Research: A 20-Year Bibliometric Analysis Based 
SO PloS one
LA English
DT Journal Article
AB OBJECTIVE: Acupuncture has become popular and widely practiced in many countries 
   around the world. Despite the large amount of acupuncture-related literature that 
   has been published, broader trends in the prevalence and scope of acupuncture 
   research remain underexplored. The current study quantitatively analyzes trends 
   in acupuncture research publications in the past 20 years. METHODS: A 
   bibliometric approach was used to search PubMed for all acupuncture-related 
   research articles including clinical and animal studies. Inclusion criteria were 
   articles published between 1995 and 2014 with sufficient information for 
   bibliometric analyses. Rates and patterns of acupuncture publication within the 
   20 year observational period were estimated, and compared with broader 
   publication rates in biomedicine. Identified eligible publications were further 
   analyzed with respect to study type/design, clinical condition addressed, country 
   of origin, and journal impact factor. RESULTS: A total of 13,320 
   acupuncture-related publications were identified using our search strategy and 
   eligibility criteria. Regression analyses indicated an exponential growth in 
   publications over the past two decades, with a mean annual growth rate of 10.7%. 
   This compares to a mean annual growth rate of 4.5% in biomedicine. A striking 
   trend was an observed increase in the proportion of randomized clinical trials 
   (RCTs), from 7.4% in 1995 to 20.3% in 2014, exceeding the 4.5% proportional 
   growth of RCTs in biomedicine. Over the 20 year period, pain was consistently the 
   most common focus of acupuncture research (37.9% of publications). Other top 
   rankings with respect to medical focus were arthritis, neoplasms/cancer, 
   pregnancy or labor, mood disorders, stroke, nausea/vomiting, sleep, and 
   paralysis/palsy. Acupuncture research was conducted in 60 countries, with the top 
   3 contributors being China (47.4%), United States (17.5%), and United Kingdom 
   (8.2%). Retrieved articles were published mostly in complementary and alternative 
   medicine (CAM) journals with impact factors ranging between 0.7 and 2.8 in the 
   top 20 journals, followed by journals specializing in neuroscience, pain, 
   anesthesia/analgesia, internal medicine and comprehensive fields. CONCLUSION: 
   Acupuncture research has grown markedly in the past two decades, with a 2-fold 
   higher growth rate than for biomedical research overall. Both the increases in 
   the proportion of RCTs and the impact factor of journals support that the quality 
   of published research has improved. While pain was a consistently dominant 
   research focus, other topics gained more attention during this time period. These 
   findings provide a context for analyzing strengths and gaps in the current state 
   of acupuncture research, and for informing a comprehensive strategy for further 
   advancing the field.
C1 Sleep Center, Air Force General Hospital, PLA, Beijing, China.
   Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess 
   IBM, Software Development Lab, Littleton, MA, United States of America.
   Department of Health Care Studies & Daemen College Physical Therapy Wound Care Clinic Daemen College, Amherst, NY, United States of America.
   Reference & Education Services, Countway Library of Medicine, Harvard Medical School, Boston, MA, United States of America.
   Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
   Division of Preventive Medicine, Osher Center for Integrative Medicine, Brigham and Women's Hospital, Boston, MA, United States of America
   Harvard MedicalSchool, Boston, MA, United States of America.
NR 0
TC 0
SN 1932-620
EI 
J9 PLoS One
PD DEC 16
PY 2016
VL 11
IS 12
BP e0168123
EP e0168123
DI 10.1371/journal.pone.0168123 
PG 1
WC Acupuncture; Acupuncture Therapy; Animals; Bibliometrics; Biomedical Research; trends; China; Humans; Journal Impact Factor; Prevalence; PubMed; Publications; trends; Randomized Controlled Trials as Topic; Regression Analysis; United Kingdom; United States
UT PubMed:27973611
PM 27973611
DA 2016-12-16
ER

PT J
AU Chao, MT
   Chang, A
   Reddy, S
   Harrison, JD
   Acquah, J
   Toveg, M
   Santana, T
   Hecht, FM
AF Chao, Maria T
   Chang, Alexandra
   Reddy, Sanjay
   Harrison, James D
   Acquah, Joseph
   Toveg, Miria
   Santana, Trilce
   Hecht, Frederick M
TI Adjunctive acupuncture for pain and symptom management in the inpatient setting: 
SO Journal of integrative medicine
LA English
DT Journal Article
AB BACKGROUND: Effective pain management among hospitalized patients is an important 
   aspect of providing quality care and achieving optimal clinical outcomes and 
   patient satisfaction. Common pharmacologic approaches for pain, though effective, 
   have serious side effects and are not appropriate for all inpatients. Findings 
   from randomized controlled trials (RCTs) support the efficacy of acupuncture for 
   many symptoms relevant to inpatients including postoperative pain, cancer-related 
   pain, nausea and vomiting, and withdrawal from narcotic use. However, the extent 
   to which findings from RCTs translate to real-world implementation of acupuncture 
   in typical hospital settings is unknown. METHODS/DESIGN: In partnership with the 
   launch of a clinical program offering acupuncture services to inpatients at the 
   University of California San Francisco's Mount Zion Hospital, we are conducting a 
   pilot study using a hybrid effectiveness-implementation design to: (1) assess the 
   effectiveness of acupuncture to manage pain and other symptoms and improve 
   patient satisfaction; and (2) evaluate the barriers and facilitators to 
   implementing an on-going acupuncture service for inpatients. During a two-month 
   pre-randomization phase, we evaluated and adapted clinical scheduling and 
   treatment protocols with acupuncturists and hospital providers and pretested 
   study procedures including enrollment, consent, and data collection. During a 
   six-month randomization phase, we used a two-tiered consent process in which 
   inpatients were first consented into a study of symptom management, randomized to 
   be offered acupuncture, and consented for acupuncture if they accepted. We are 
   also conducting in-depth interviews and focus groups to assess evidence, context, 
   and facilitators of key provider and hospital administration stakeholders. 
   DISCUSSION: Effectiveness research in "real-world" practice settings is needed to 
   inform clinical decision-making and guide implementation of evidence-based 
   acupuncture practices. To successfully provide clinical acupuncture services and 
   maintain a rigorous research design, practice-based trials of acupuncture require 
   careful planning and attention to setting-specific, contextual factors. TRIAL 
   REGISTRATION: This trial has been registered in ClinicalTrials.gov. The 
   identifier is NCT01988194, registered on November 5, 2013.
C1 Osher Center for Integrative Medicine, University of California San Francisco, San Francisco, California 94143, USA.
   Division of General Internal Medicine, Zuckerberg San Francisco General Hospital, 
   Departments of Anesthesiology and Internal Medicine, Loma Linda University, Loma Linda, California 92354, USA.
   Osher Center for Integrative Medicine, University of California San Francisco, San Francisco, California 94143, USA.
   Division of Hospital Medicine, University of California San Francisco, San 
   Division of Hospital Medicine, University of California San Francisco, San Francisco, California 94143, USA.
   Osher Center for Integrative Medicine, University of California San Francisco, San Francisco, California 94143, USA.
   Osher Center for Integrative Medicine, University of California San Francisco, San Francisco, California 94143, USA.
   Osher Center for Integrative Medicine, University of California San Francisco, San Francisco, California 94143, USA.
   Osher Center for Integrative Medicine, University of California San Francisco, San Francisco, California 94143, USA.
NR 0
TC 0
SN 
EI 2095-496
J9 J Integr Med
PD MAY 18
PY 2016
VL 14
IS 3
BP 228
EP 38
DI 10.1016/S2095-4964(16)60252-2 
PG -190
WC Acupuncture Therapy; Clinical Protocols; Humans; Inpatients; Pain Management; Pilot Projects
UT PubMed:27181130
PM 27181130
DA 2016-05-18
ER

PT J
AU Mahfudh, SS
AF Mahfudh, Salma Said
TI Historical perspectives and trends in the management of pain for cancer patients 
SO Asian Pacific journal of cancer prevention : APJCP
LA English
DT Journal Article
AB INTRODUCTION: Sultanate of Oman is the second largest country in the Gulf, with a 
   population of 2,867,428 (2008) of which 35.2% is under 15 years and only 3.7% 
   above 65 years. Incidence of newly diagnosed cancers is also the second highest 
   in the Gulf with 11%. Research conducted between 1997-2007 revealed that the most 
   frequent cancers in males: stomach 10%, non-Hodgkins lymphoma 8.6% and prostate 
   7% while in females: breast 18.9%, thyroid 8.3% and cervix uteri 6.5%. A 
   population-based registry was established in 1996 to compile an accurate database 
   and monitor cancer trends. There is a rigorous follow up of reported cases. 
   Unfortunately most patients report at the hospitals in advanced stages which 
   complicate pain management. All treatment modalities of cancer are available in 
   Oman at the two centers, Royal Hospital and SQUH. There is a continuous effort to 
   develop national educational guidelines, protocols for cancer treatment, 
   palliative care and pain management (PM). HISTORICAL PERSPECTIVES AND TRENDS IN 
   THE MANAGEMENT OF PAIN: In 1970s Omanis used traditional medicine, wassam 
   (moxibustion), to treat pain. In 1988 severe pain was treated in hospitals with 
   intramuscular opioid, whenever necessary (PRN). 1989 SQUH approved use of both 
   parenteral and oral narcotics, received its first consignment, and started PM. 
   The Ministry of Health (MOH) was concerned with possible misuse and for 8 years, 
   thereafter, SQUH was the only hospital allowed to import, stock, prescribe and 
   dispense oral narcotics. Legal requirement to obtain opioids in Oman involves MOH 
   and World Health Organization (WHO) and there is a control as to who can 
   prescribe for both inpatient and outpatient. The drugs available to control pain 
   include non opioids, weak opioids, but the only strong opioids used for severe 
   cancer pain are morphine and Fentanyl. This is complemented with adjuvant drugs. 
   We use the "WHO Ladder" to guide us in the management of pain. Three different 
   cases have been presented to see how PM of cancer patients has evolved from using 
   only non-opioid in 1993, to using intramuscular pethidine in 1995, then to using 
   morphine with adjuvants in 1999. Referral of patients to the PM Team has improved 
   the pain control and at present even without referral, pain is controlled more 
   effectively. CONCLUSION: There is no doubt that the Sultanate of Oman has 
   progressed tremendously since 1970. The Government is working very hard and is 
   taking major steps to improve cancer care in order to meet the International 
   Bench Mark. Each 5 year plan focuses on actual needs. One of the important needs 
   that have been addressed is the management of pain which has significantly 
   improved. Factors that have improved PM in Oman include the introduction of the 
   PM Teams, training of Nurses and Doctors, follow up of the PM services in the 
   clinical areas, authorizing MOH hospitals to use oral opioids, opening of the 
   National Oncology Centre with Radiation Therapy, inter institutional discussions 
   and development of guidelines, implementation of WHO Guidelines on PM and audits, 
   peer reviews and research.
C1 Sultan Qaboos University Hospital, POBox 38, Code 123, Al Khodh, Sultanate of Oman.
NR 0
TC 0
SN 2476-762
EI 
J9 Asian Pac J Cancer Prev
PD APR 1
PY 2010
VL 11 Suppl 1
IS 
BP 93
EP 6
DI 
PG -87
WC Analgesics, Opioid; therapeutic use; Fentanyl; therapeutic use; Humans; Morphine; therapeutic use; Neoplasms; drug therapy; Oman; Pain; drug therapy
UT PubMed:20590357
PM 20590357
DA 2010-04-01
ER

PT J
AU Peng, Y
   Wei, X
   Sun, L
   Wang, K
   Zhou, J
AF Peng, Yanbin
   Wei, Xuqiang
   Sun, Linxi
   Wang, Ke
   Zhou, Jia
TI Electroacupuncture and Transcutaneous Electrical Acupoint Stimulation for 
SO JMIR research protocols
LA English
DT Journal Article
DE cardiac surgery; elderly patients; meta-analysis; perioperative neurocognitive disorder; systematic review
AB BACKGROUND: Perioperative neurocognitive disorder (PND) is a critical concern for 
   older patients undergoing cardiac surgery, impacting cognitive function and 
   quality of life. Electroacupuncture and transcutaneous electrical acupoint 
   stimulation (TEAS) hold promise for mitigating PND. This protocol outlines a 
   systematic review and meta-analysis to thoroughly assess the efficacy of 
   electroacupuncture and TEAS in older patients undergoing cardiac surgery with 
   PND, providing up-to-date evidence for PND prevention and treatment. OBJECTIVE: 
   This study aimed to thoroughly assess the efficacy of electroacupuncture and TEAS 
   in older patients undergoing cardiac surgery with PND, providing up-to-date 
   evidence for PND prevention and treatment. METHODS: A comprehensive and 
   systematic approach will be used to identify eligible studies from a diverse 
   range of electronic databases, including 9 major sources such as PubMed (NLM) and 
   Cochrane (Wiley), as well as 2 clinical trial registration websites. These 
   studies will focus on investigating the effects of electroacupuncture and TEAS on 
   PND in older patients undergoing cardiac surgery. The study selection will adhere 
   to the criteria outlined in the patient, intervention, comparison, outcome, and 
   studies (PICOS) format. Data extraction will be carried out by 2 independent 
   researchers (YP and LS), using established tools to evaluate the risk of bias. 
   The primary outcome will be PND incidence, with secondary outcomes including Mini 
   Mental State Examination scores, neuron-specific enolase, S100β, interleukin-1β, 
   interleukin-6, tumor necrosis factor-α, time to first flatus, first defecation, 
   bowel sound recovery, and hospitalization duration to be selectively reported. 
   Adverse events linked to acupuncture, such as bleeding, needle site pain, and 
   local reactions, rather than serious adverse events, will also be considered. 
   Meta-analysis will be performed using appropriate statistical methods to assess 
   the overall effect of electroacupuncture and TEAS on PND prevention, treatment, 
   or other relevant outcomes. The Cochrane Collaboration Risk of Bias tool will be 
   used for assessment, and data synthesis will be executed using the RevMan 5.4 
   software (Cochrane). RESULTS: We plan to summarize the eligible studies through 
   the use of a PRISMA (Preferred Reporting Items for Systematic Reviews and 
   Meta-Analyses) flowchart. The findings will be showcased in the form of a summary 
   table of evidence. Figures and forest plots will be used to illustrate the 
   outcomes of the meta-analysis. CONCLUSIONS: The impacts of electroacupuncture and 
   TEAS interventions on PND in older patients undergoing cardiac surgery have not 
   yet been established. This protocol addresses a critical gap by thoroughly 
   assessing electroacupuncture and TEAS for PND in older patients undergoing 
   cardiac surgery, enhancing understanding of nonpharmacological interventions, and 
   guiding future research and clinical practices in this field. Its strength lies 
   in rigorous methodology, including comprehensive search strategies, independent 
   review processes, and thorough assessments of the risk of bias. TRIAL 
   REGISTRATION: PROSPERO CRD42023411927; https://tinyurl.com/39xdz6jb. 
   INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/55996.
C1 Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, China.
   Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, China.
   Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, China.
   Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, China.
   Office of National Clinical Research Base of TCM, Yueyang Hospital of Integrated 
   Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, China.
   Office of National Clinical Research Base of TCM, Yueyang Hospital of Integrated 
NR 0
TC 0
SN 1929-074
EI 
J9 JMIR Res Protoc
PD AUG 31
PY 2024
VL 13
IS 
BP e55996
EP e55996
DI 10.2196/55996 
PG 1
WC Aged; Humans; Acupuncture Points; Cardiac Surgical Procedures; adverse effects; Electroacupuncture; methods; Meta-Analysis as Topic; Neurocognitive Disorders; etiology; Postoperative Complications; prevention & control; Systematic Reviews as Topic; Transcutaneous Electric Nerve Stimulation; methods
UT PubMed:39208417
PM 39208417
DA 2024-08-31
ER

PT J
AU Chen, J
   Zhang, Y
   Wang, P
   Wang, B
   Zhang, G
   Wang, X
AF Chen, Jia
   Zhang, Yunfeng
   Wang, Peiru
   Wang, Bo
   Zhang, Guolong
   Wang, Xiuli
TI Plum-blossom needling promoted PpIX fluorescence intensity from 5-aminolevulinic 
SO Photodiagnosis and photodynamic therapy
LA English
DT Journal Article
DE Fractional ablative resurfacing; Photodynamic therapy; Photosensitizer; Plum-blossom needling; Topical drugs
AB BACKGROUND AND OBJECTIVES: Plum-blossom needling might enhance transdermal 
   penetration of topically applied drugs by creating vertical channels. The purpose 
   of this study was to evaluate drug delivery assisted by plum-blossom needling 
   comparing with CO2 laser ablative fractional resurfacing (AFR) using 
   5-aminolevulinic acid (5-ALA), a porphyrin precursor, as a test drug. MATERIALS 
   AND METHODS: Ex vivo porcine skin was treated with plum-blossom needle(HWATO, 
   Suzhou medical supplies factory Co., Ltd. China) or CO2 laser AFR before topical 
   application of 20% 5-ALA(Sigma-Aldrich, Co., USA)cream, placebo cream and no 
   cream. ALA-induced porphyrin fluorescence was measured by fluorescence microscopy 
   at skin depths down to 1800μm. Needling was done by tapping the skin vertically 
   from 5cm high above quickly. AFR was performed with a 10.6μm wavelength prototype 
   CO2 laser, using stacked single pulses of 3 millisecond and 91.6mJ per pulse. 
   Plum-blossom needling after ALA application was also done. Fluorescence intensity 
   on lesion surface was examined by curalux spectrum analyzer (Laser Institute of 
   Munich University, Germany) and VAS pain score was recorded in a randomized 
   split-lesion clinical trial including 6 patients, 8 actinic keratosis lesions. 
   RESULTS: AFR created regular cone-shaped channels surrounded by a 70μm thin layer 
   of thermally coagulated dermis, respectively. The cone is approximately 200μm in 
   diameter at the opening and 1850μm in depth. Plum-blossom needle created 
   irregular cone-shaped channels of approximately 180μm in diameter at the opening 
   and it always drags a tail-which was shaped from the closed deeper channels. 
   There was no porphyrin fluorescence in placebo cream or untreated skin sites. 
   Plum-blossom needling followed by ALA application enhanced drug delivery with 
   significantly higher porphyrin fluorescence at the edge of hole (P<0.005) and 
   100μm far from the hole (P=0.000) versus AFR followed by ALA application at skin 
   depths of 120 and 500μm. Needling after ALA application presented higher 
   porphyrin fluorescence at the edge of hole at skin depths of 120μm (P<0.005) and 
   lower porphyrin fluorescence at 1000μm deep hole edge, and 100μm far from the 
   hole at 120μm, 500μm and 1000μm depths versus AFR followed by ALA application 
   (P<0.005). Skin massage after ALA application did not affect ALA-induced 
   porphyrin fluorescence after pretreatment of plum-blossom needling or AFR. ALA 
   application after plum-blossom needling was better than before plum-blossom 
   needling. The clinical trial showed that the surface fluorescence intensity was 
   stronger in needle-pretreated-lesion than in laser-pretreated-lesion. While the 
   VAS pain score between needle treatment and laser treatment was almost the same. 
   CONCLUSIONS: Plum-blossom needling facilitates delivery of topical ALA into the 
   dermis. It may help ALA to diffuse a little more broadly than AFR does in 
   superficial dermis and obtain similar clinical effect with a much lower cost. 
   Plum-blossom needling treatment appears to be a clinically practical and 
   economical means for enhancing transdermal delivery of ALA, a photodynamic 
   therapy drug, and presumably many other topical skin medications.
C1 Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, PR China. 
   Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, PR China. 
   Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, PR China. 
   Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, PR China. 
   Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, PR China. 
   Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, PR China. 
EM Wangxiuli20150315@163.com
NR 0
TC 0
SN 1873-159
EI 
J9 Photodiagnosis Photodyn Ther
PD JUL 5
PY 2016
VL 15
IS 
BP 182
EP 90
DI 10.1016/j.pdpdt.2016.06.012 
PG -92
WC Acupuncture Therapy; instrumentation; Aged; Aminolevulinic Acid; pharmacokinetics; Animals; Female; Fluorescent Dyes; pharmacokinetics; Humans; In Vitro Techniques; Keratosis, Actinic; metabolism; Male; Microscopy, Fluorescence; methods; Middle Aged; Photosensitizing Agents; pharmacokinetics; Protoporphyrins; pharmacokinetics; Skin; metabolism; Skin Absorption; physiology; Swine
UT PubMed:27375183
PM 27375183
DA 2016-07-05
ER

PT J
AU Bidan, L
   Gong, P
   Zhang, W
   Li, J
   Huang, J
   Yu, Z
AF Bidan, Lou
   Gong, Ping
   Zhang, Wei
   Li, Jinxiang
   Huang, Jie
   Yu, Zhaoan
TI [Theoretical study of corresponding points for pain].
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB The theoretical basis of "corresponding points" originates from opposing 
   needling, contralateral needling and distal needling in acupuncture. It is to 
   select points in corresponding area that is distant from diseased re gion to 
   balance yin and yang and to activate meridians. Acupuncture at corresponding 
   points, through reflex regu- lation of nervous system. could activate protective 
   inhibition of cerebral cortex and cutoff of local malignant stimu lation, leading 
   to quick elimination of pain. In clinic, it is mostly used for pain-related 
   diseases.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD APR 25
PY 2015
VL 35
IS 1
BP 77
EP 9
DI 
PG -68
WC Acupuncture Points; Acupuncture Therapy; Humans; Medicine in Literature; Pain Management
UT PubMed:25906577
PM 25906577
DA 2015-04-25
ER

PT J
AU Lu, Z
   Moody, J
   Marx, BL
   Hammerstrom, T
AF Lu, Zhaoxue
   Moody, Jennifer
   Marx, Benjamin L
   Hammerstrom, Tracy
TI Treatment of Chemotherapy-Induced Peripheral Neuropathy in Integrative Oncology: 
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
DE acupuncture; chemotherapy-induced peripheral neuropathy; integrative oncology; neurological pain; neuropathic pain
AB OBJECTIVES: Complementary and alternative medicine is increasingly integrated 
   into cancer care. We sought detail on the treatment of chemotherapy-induced 
   peripheral neuropathy (CIPN) with acupuncture and oriental medicine (AOM) by 
   surveying practitioners at integrative oncology (IO) sites across the United 
   States. DESIGN: Online survey of licensed acupuncturists. SETTING/LOCATION: IO 
   sites in the United States. SUBJECTS: Fifteen licensed acupuncturists who 
   completed the survey between February 2014 and June 2014. OUTCOME MEASURES: 
   Demographics, IO setting characteristics, AOM treatment characteristics, and 
   practitioner-reported outcomes. RESULTS: Respondents reported an average of 
   31.3 ± 17.2 patients per week, and one-third (10.1 mean; 7.2 standard deviation 
   [SD]) were treated for CIPN. Medical doctors (86.7%) were the most common 
   providers with whom respondents worked. Traditional Chinese medicine style 
   acupuncture was utilized by a majority of respondents (86.7%), and the most 
   commonly used points were local, typically in the hands and feet, such as Ba 
   Feng, Ba Xie, LV3, and LI4. In addition to acupuncture, nutritional advice was 
   the most frequent auxiliary modality provided by respondents (85.7%). On average, 
   respondents provided 12.75 ± 4.17 treatments for CIPN patients, and a majority 
   (53%) reported treating patients once per week. Timing of the treatments relative 
   to chemotherapy infusion was evenly distributed between "1-2 days after infusion" 
   (60%), "at time of infusion" (53.3%), and "1-2 days before infusion" (46.7%). 
   Sixty percent of respondents rated outcomes as "moderately successful with 
   moderate improvement seen." CONCLUSION: This survey provides detail regarding IO 
   sites using acupuncture for CIPN as well as real-world treatment patterns, 
   including common point combinations, visit characteristics, and 
   practitioner-reported outcomes. This information contributes to the emerging 
   evidence on the use of acupuncture to address unmet needs of CIPN patients, and 
   supports the development of best practice guidelines for the treatment of CIPN 
   with acupuncture in the IO setting.
C1 Oregon College of Oriental Medicine , Portland, OR.
   Oregon College of Oriental Medicine , Portland, OR.
   Oregon College of Oriental Medicine , Portland, OR.
   Oregon College of Oriental Medicine , Portland, OR.
NR 0
TC 0
SN 1557-770
EI 
J9 J Altern Complement Med
PD JUL 1
PY 2017
VL 23
IS 12
BP 964
EP 970
DI 10.1089/acm.2017.0052 
PG 6
WC Acupuncture; organization & administration; Acupuncture Therapy; statistics & numerical data; Adult; Cross-Sectional Studies; Female; Health Personnel; Humans; Integrative Oncology; Male; Medicine, Chinese Traditional; Middle Aged; Peripheral Nervous System Diseases; chemically induced; Surveys and Questionnaires
UT PubMed:28661695
PM 28661695
DA 2017-07-01
ER

PT J
AU D'Alessandro, EG
   Nebuloni, Nagy DR
   de, Brito CMM
   Almeida, EPM
   Battistella, LR
   Cecatto, RB
AF D'Alessandro, Eduardo Guilherme
   Nebuloni Nagy, Daniela Ribeiro
   de Brito, Christina May Moran
   Almeida, Elisangela Pinto Marinho
   Battistella, Linamara Rizzo
   Cecatto, Rebeca Boltes
TI Acupuncture for chemotherapy-induced peripheral neuropathy: a randomised 
SO BMJ supportive & palliative care
LA English
DT Journal Article
DE acupuncture; chemotherapy; neuropathy; quality of life; rehabilitation
AB Chemotherapy-induced peripheral neuropathy (CIPN) can cause loss of independence 
   and poor quality of life (QoL) due to severe disabilities, but in spite of its 
   importance there is still a lack of data for the management of CIPN. Acupuncture 
   has showed promising results and may be a cost-effective option for the 
   treatment. OBJECTIVES: To evaluate the effect of acupuncture treatment on 
   neurological symptoms of CIPN and QoL of oncological patients. METHODS: We 
   performed a clinical, single-centre, randomised and controlled pilot study that 
   involved 33 adult patients with cancer and CIPN randomised into two groups 
   (control and acupuncture treated with 10 sessions, two times per week). Both 
   groups were subjected to a complete physical examination and clinical assessment 
   with National Cancer Institute Common Terminology Criteria for Adverse Events 
   (NCI CTCAE) Scale V.2.0, FIM Scale, European Organisation for the Research and 
   Treatment of Cancer Quality of Life Questionnaire Core (EORTC QLQ-C30) Scale and 
   Visual Analogue Scale for pain before and 5 weeks after treatment. RESULTS: There 
   were no adverse events, and we found statistical differences in groups in 
   physical (p=0.03) and function (p=0.04) domains of EORTC QLQ-C30 when comparing 
   control and acupuncture groups. About NCI CTCAE Scale and neuropathy sensory 
   symptoms, we found better results in acupuncture group, comparing pretreatment 
   and post-treatment analyses (p=0.01). In control group, we have no differences 
   after 5 weeks (p=0.11). CONCLUSION: Although these results suggest an interesting 
   effect of acupuncture on this patient population, the clinical significance has 
   remained unclear. Given the tendency towards benefit and the lack of adverse 
   effects, the authors recommend a follow-up acupuncture trial using higher 
   follow-up time and better sample size. TRIAL REGISTRATION NUMBER: NCT02309164.
C1 Instituto do Cancer, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brasil.
   Instituto do Cancer, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brasil.
   Rehabilitation Department, Instituto do Cancer, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
   Rehabilitation Service, Hospital Sírio-Libanês, Sao Paulo, Brasil.
   Rehabilitation Department, Instituto do Cancer, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
   Department of Legal Medicine, Medical Ethics, Social and Work Medicine, Faculdade de Medicina, Universidade de São Paulo (USP), Sao Paulo, Brazil.
   Instituto de Medicina Física e de Reabilitação, Hospital das Clinicas 
   Rehabilitation Department, Instituto do Cancer, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazilrebeca.boltes@gmail.com.
   School of Medicine, Universidade Nove de Julho, Sao Paulo, Brazil.
NR 0
TC 0
SN 2045-436
EI 
J9 BMJ Support Palliat Care
PD JUL 1
PY 2019
VL 12
IS 1
BP 64
EP 72
DI 10.1136/bmjspcare-2018-001542 
PG 8
WC Acupuncture Therapy; adverse effects; Adult; Antineoplastic Agents; adverse effects; Humans; Peripheral Nervous System Diseases; chemically induced; Pilot Projects; Quality of Life
UT PubMed:31256014
PM 31256014
DA 2019-07-01
ER

PT J
AU Spinato, IL
   Antunes, TDC
   Politti, F
   Izidio, REN
   Biasotto-Gonzalez, DA
   Gondim, DV
AF Spinato, Itana Lisane
   Antunes, Taisi da Cunha
   Politti, Fabiano
   Izidio, Ruth Ellen Nogueira
   Biasotto-Gonzalez, Daniela Aparecida
   Gondim, Delane Viana
TI Electroacupuncture Protocol for Sensory and Motor Function Recovery After 
SO Journal of acupuncture and meridian studies
LA English
DT Journal Article
DE Clinical protocol; Electroacupuncture; Motor function; Orthognathic surgery; Paresthesia
AB IMPORTANCE: Orthognathic surgery is utilized to rectify facial deformities, but 
   it can lead to neurosensory alterations. Electroacupuncture has been shown to 
   enhance sensitivity and motor functions in patients post-surgery. However, its 
   application in traumatic facial injuries remains inadequately researched. 
   OBJECTIVE: To investigate the effects of electroacupuncture on sensitivity and 
   orofacial function in patients undergoing orthognathic surgery. DESIGN, SETTING, 
   AND POPULATION: A randomized clinical trial involving patients undergoing 
   bimaxillary orthognathic surgery and genioplasty who are randomly allocated to 
   either a physiotherapy (PT) or physiotherapy plus electroacupuncture group 
   (PTEA). EXPOSURES: Participants will be allocated to their respective therapies 
   for a duration of six weeks. The PT group will receive a 50-minute physical 
   therapy session along with 30 minutes of simulated procedure. The PTEA group will 
   receive 50 minutes of physical therapy followed by 30 minutes of 
   electroacupuncture. MAIN OUTCOMES AND MEASURES: Before treatment, sensitivity 
   will be assessed using the SMILE Sensitivity Test-BAURU kit, edema will be 
   evaluated using the MD Anderson Cancer Center Head and Neck Lymphedema protocol, 
   range of motion will be measured using a digital caliper, and muscle pain and 
   fatigue will be gauged using numerical scales. The chewing function will be 
   evaluated using the Chewing Quality Assessment Questionnaire. RESULTS: All 
   assessments will be repeated at three and six months following the initiation of 
   treatment. CONCLUSIONS AND RELEVANCE: This study may provide reliable and 
   high-quality clinical evidence regarding the impact of electroacupuncture on 
   restoring altered sensation and motor function in patients undergoing 
   orthognathic surgery.
C1 Postgraduate Program in Morphofunctional Sciences, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
   Postgraduate Program in Rehabilitation Sciences, Ninth of July University, São Paulo, São Paulo, Brazil.
   Postgraduate Program in Rehabilitation Sciences, Ninth of July University, São Paulo, São Paulo, Brazil.
   Undergraduate Student, Physiotherapy Course, Estácio University Center, Fortaleza, Ceará, Brazil.
   Postgraduate Program in Rehabilitation Sciences, Ninth of July University, São Paulo, São Paulo, Brazil.
   Postgraduate Program in Morphofunctional Sciences, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
NR 0
TC 0
SN 2093-815
EI 
J9 J Acupunct Meridian Stud
PD OCT 24
PY 2024
VL 17
IS 5
BP 178
EP 186
DI 10.51507/j.jams.2024.17.5.178 
PG 8
WC Adult; Female; Humans; Male; Young Adult; Electroacupuncture; methods; Orthognathic Surgery; methods; Orthognathic Surgical Procedures; Recovery of Function; Randomized Controlled Trials as Topic
UT PubMed:39444103
PM 39444103
DA 2024-10-24
ER

PT J
AU Victorson, D
   Beaumont, JL
   Mahadevan, R
   Grimone, A
   Burns, V
   Murry, W
   Gutierrez, S
   Schuette, S
   Brady, C
   Ring, M
AF Victorson, David
   Beaumont, Jennifer L
   Mahadevan, Rupa
   Grimone, Ania
   Burns, Virginia
   Murry, Wendy
   Gutierrez, Sandra
   Schuette, Stephanie
   Brady, Caitlin
   Ring, Melinda
TI Acupuncture-Related Quality of Life Changes Using PROMIS Computer Adaptive Tests 
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
DE acupuncture; outcomes; pragmatic trial; quality of life
AB INTRODUCTION: Acupuncture has been shown to alleviate symptoms and increase 
   general well-being in different medical patient samples. A major challenge in 
   acupuncture clinical research is the availability of comparable and standardized 
   patient-reported outcome measurement (PRO) tools. OBJECTIVES: This study used a 
   pragmatic design to examine longitudinal changes in quality of life (QOL) in a 
   medical patient sample following acupuncture using PROs from the National 
   Institutes of Health's Patient Reported Outcomes Measurement Information System 
   (PROMIS) initiative. It also examined the role of acupuncture expectancies, as 
   well as patient and provider perceptions of acupuncture benefit. DESIGN: 
   Following informed consent, patients completed baseline QOL measures (T1) prior 
   to their first acupuncture session. Subsequent assessments (up to 20) were 
   completed immediately following ensuing acupuncture sessions. Patients completed 
   assessments either on a touch-screen computer at the clinic or from their home 
   computer. RESULTS: Compared with acupuncture-naïve participants, those who 
   received prior acupuncture treatment reported significantly higher anxiety, 
   fatigue, sleep disturbance, and lower positive affect at baseline. By the second 
   assessment, however, these differences became nonexistent. Participants who held 
   greater baseline acupuncture expectations (e.g., their situation would improve a 
   lot, they would have improved coping skills, their symptoms would disappear, 
   their energy would increase) reported significantly higher fatigue, pain 
   interference, and problems with physical functioning. Between T1 and T2, all 
   participants reported significant improvements in anxiety, depression, and 
   fatigue. Exploratory longitudinal models demonstrated significant linear 
   improvements over time in anxiety (p = 0.006), depression (p = 0.007), pain 
   interference (p < 0.001), and sleep disturbance (p = 0.004). No linear reduction 
   over time was found with fatigue (p = 0.587), physical function (p = 0.654), or 
   positive affect (p = 0.247). CONCLUSIONS: Overall, PROMIS computer adaptive tests 
   were able to assess domains of QOL briefly. Although pretreatment acupuncture 
   expectations highlighted subgroup differences in outcomes at baseline, 
   linear-growth models demonstrated the positive effects of acupuncture over time 
   on anxiety, depression, pain interference, and sleep disturbance.
C1 1 Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine , Chicago, IL.
   2 Osher Center for Integrative Medicine at Northwestern Medicine , Northwestern 
   1 Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine , Chicago, IL.
   3 Pediatric Residency Program, Advocate Children's Hospital , Park Ridge, IL.
   2 Osher Center for Integrative Medicine at Northwestern Medicine , Northwestern Medical Group, Chicago, IL.
   2 Osher Center for Integrative Medicine at Northwestern Medicine , Northwestern Medical Group, Chicago, IL.
   2 Osher Center for Integrative Medicine at Northwestern Medicine , Northwestern Medical Group, Chicago, IL.
   1 Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine , Chicago, IL.
   2 Osher Center for Integrative Medicine at Northwestern Medicine , Northwestern Medical Group, Chicago, IL.
   2 Osher Center for Integrative Medicine at Northwestern Medicine , Northwestern Medical Group, Chicago, IL.
   2 Osher Center for Integrative Medicine at Northwestern Medicine , Northwestern Medical Group, Chicago, IL.
NR 0
TC 0
SN 1557-770
EI 
J9 J Altern Complement Med
PD JUL 29
PY 2016
VL 22
IS 10
BP 778
EP 787
DI 10.1089/acm.2015.0121 
PG 9
WC Acupuncture Therapy; psychology; Adult; Aged; Female; Humans; Integrative Medicine; statistics & numerical data; Male; Middle Aged; Patient Satisfaction; statistics & numerical data; Quality of Life; Young Adult
UT PubMed:27467506
PM 27467506
DA 2016-07-29
ER

PT J
AU Chien, TJ
   Liu, CY
   Fang, CJ
   Kuo, CY
AF Chien, Tsai-Ju
   Liu, Chia-Yu
   Fang, Ching-Ju
   Kuo, Chun-Yu
TI The Efficacy of Acupuncture in Chemotherapy-Induced Peripheral Neuropathy: 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; cancer; chemotherapy; neuropathy; systematic review
AB Background: Chemotherapy-induced peripheral neuropathy (CIPN) has no cure, but 
   acupuncture may provide relief through its known neuromodulation or 
   neuroendocrine adjustment. This review aimed to assess the efficacy of 
   acupuncture in treating CIPN. Method: A literature review following the PRISMA 
   Statement was performed, searching 7 databases from inception through August 
   2019. All studies were clinical trials of the effect of acupuncture on CIPN. The 
   methodological quality of these trials was assessed using Cochrane criteria; 
   meta-analysis software (RevMan 5.2) was used to analyze the data. Data Sources: 
   The databases searched were the following: MEDLINE (Ovid), Embase, Cochrane 
   CENTRAL, Scopus, World Health Organization International Clinical Trials Registry 
   Platform, CNKI (China National Knowledge Infrastructure), and Wanfang Med Online. 
   Results: We examined 386 cancer patients from 6 randomized control trials, which 
   had high quality, based on the modified Jadad scale. Meta-analysis showed that 
   acupuncture led to significant improvements in pain scores (-1.21, 95% confidence 
   interval [CI] = -1.61 to -0.82, P < .00001) and nervous system symptoms based on 
   Functional Assessment of Cancer Therapy/Neurotoxicity questionnaire scores 
   (-2.02, 95% CI = -2.21 to -1.84, P < .00001). No significant change was noted in 
   nerve conduction velocity (1.58, 95% CI = -2.67 to 5.83, P = .47). Conclusion: 
   Acupuncture can effectively relieve CIPN pain and functional limitation. The 
   limited number of subjects warrants a larger scale study.
C1 Taipei City Hospital, Taipei.
   National Yang-Ming University, Taipei.
   National Yang-Ming University, Taipei.
   Chang Gung University, Taoyuan.
   China Medical University, Taichung.
   Flourish Traditional Chinese Medicine Clinic, Taipei.
   National Cheng Kung University, Tainan.
   National Cheng Kung University Hospital, Tainan.
   National Yang-Ming University, Taipei.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD DEC 14
PY 2019
VL 18
IS 
BP 1534735419886662
EP 1534735419886662
DI 10.1177/1534735419886662 
PG 1
WC Acupuncture Therapy; methods; Antineoplastic Agents; adverse effects; China; Clinical Trials as Topic; Humans; Peripheral Nervous System Diseases; chemically induced; Randomized Controlled Trials as Topic; Surveys and Questionnaires
UT PubMed:31833790
PM 31833790
DA 2019-12-14
ER

PT J
AU Bossi, P
   Ghiani, M
   Argenone, A
   Depenni, R
AF Bossi, Paolo
   Ghiani, Massimo
   Argenone, Angela
   Depenni, Roberta
TI Is pain part of a systemic syndrome in head and neck cancer?
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Review
DE Head and neck cancer; Multidisciplinary approach; Opioids; Pain; Pain management
AB Head and neck cancers (HNC) represent 5% of all malignancies worldwide with about 
   180,000 cancer deaths per year. Patients with HNC are characterized by a systemic 
   inflammatory state, generally associated with worse outcomes. Treatment-related 
   toxicity is common among HNC patients and causes systemic consequences such as 
   fatigue or cognitive dysfunction. The therapeutic treatments of HNC involve the 
   release in circulation of inflammatory systemic mediators, whose effects trigger 
   a vicious circle that may lead to functional and behavioral alterations. The 
   areas of the head and neck are highly sensitive to pain. Literature data confirm 
   that in HNC patients, pain is one of the most distressing symptoms across all the 
   phases of treatment. Pain is associated with worse general conditions, 
   depression, fatigue, impaired cognitive functions, and lower survival rate. The 
   treatment of advanced HNC cases is multimodal and requires a multidisciplinary 
   psycho-socio-pharmacological approach mediated by a team of experts. The 
   pharmacological approach in management of HNC patients with pain is fundamental 
   and involves the use of opioids, NSAIDs, steroids, or other drugs. Opioids in 
   pain management therapy in patients with HNC could allow the pain level to be 
   adequately monitored, thus improving quality of life. The integration of opioid 
   and non-opioid therapy as well as non-pharmacological interventions is essential 
   for the rehabilitation of physical, social, and psychological functions and to 
   achieve pain control in patients with HNC. Opioid treatment is the mainstay for 
   pain control, being used both for background and breakthrough cancer pain (BTcP) 
   episodes. Fentanyl, easily absorbed and generally well tolerated, appears to be a 
   possible choice due to its versatility. Non-pharmacological interventions, such 
   as tailored yoga, physical exercise, and acupuncture, may have a role in pain 
   management in patients with HNC.
C1 Medical Oncology, ASST Spedali Civili Brescia, Brescia, Italy. paolo.bossi@unibs.it.
   Department of Medical and Surgical Specialties, Radiological Sciences and Public 
   Oncology Department, A. Businco Hospital, Cagliari, Italy.
   Radiation Oncology Department, Istituto Nazionale Tumori-IRCCS-G. Pascale Foundation, Naples, Italy.
   Oncology and Haematology Department, University Hospital of Modena and Reggio Emilia, Modena, Italy.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD NOV 13
PY 2019
VL 28
IS 2
BP 451
EP 459
DI 10.1007/s00520-019-05147-8 
PG 8
WC Analgesics, Opioid; administration & dosage; Breakthrough Pain; drug therapy; Cancer Pain; drug therapy; Depression; Exercise; Fatigue; chemically induced; Fentanyl; administration & dosage; Head and Neck Neoplasms; pathology; Humans; Pain Management; methods; Quality of Life; psychology
UT PubMed:31713692
PM 31713692
DA 2019-11-13
ER

PT J
AU Deng, XY
   Xu, TS
AF Deng, Xiao-Yue
   Xu, Tian-Shu
TI [Clinical observation of acupuncture combined with sertraline hydrochloride 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture; depression; randomized controlled trial (RCT); sertraline hydrochloride tablets; tumor
AB OBJECTIVE: To compare the clinical effects of acupuncture combined with 
   sertraline hydrochloride and simple sertraline hydrochloride on tumor-related 
   depression. METHODS: Sixty patients with tumor-related depression who met the 
   inclusion criteria were randomly assigned to an observation group and a control 
   group, 30 patients in each group. The routine treatment in department of oncology 
   were given in both groups, oral sertraline hydrochloride (25 mg daily for the 
   first 5 days, then 50 mg daily) was given in the control group; on the basis of 
   the treatment in the control group, and acupuncture was applied at Hegu (LI 4), 
   Neiguan (PC 6), Taichong (LR 3), Shenmen (HT 7)，etc. in the observation 
   group，twice a week .The two groups were treated continuously for 4 weeks. The 
   Hamilton depression scale (HAMD) score and the quality of life score (QLQ-C30 
   questionnaire) were compared between the two groups before and after treatment. 
   RESULTS: After treatment, the HAMD scores in the two groups were significantly 
   lower than those before treatment (both P<0.05), and the HAMD scores in the 
   observation group were lower than those in the control group (P<0.05). In the 
   observation group, the symptom scores of fatigue, pain, nausea and vomiting, 
   dyspnea, insomnia, loss of appetite, constipation, and diarrhea were 
   significantly lower than those before treatment (all P<0.05), and the physical, 
   cognitive, emotional function, and the overall quality of life score were 
   significantly higher than those before treatment (all P<0.05); in the control 
   group, the symptom scores of insomnia decreased compared with that before 
   treatment (P<0.05), and the emotional function and overall quality of life score 
   were higher than those before treatment (both P<0.05); in addition to economic 
   difficulties, roles and social functions, the other scores after treatment in the 
   observation group were significantly improved than those in the control group 
   (all P<0.05). CONCLUSION: The combination of acupuncture and sertraline 
   hydrochloride tablets is better than simple sertraline hydrochloride in the 
   treatment of tumor-related depression, and it can improve the accompanying 
   symptoms and improve quality of life.
C1 Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of CM, Nanjing 210046, Jiangsu Province, China.
   Drum Tower Hospital of Nanjing, Nanjing 210008.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD APR 9
PY 2019
VL 39
IS 4
BP 379
EP 83
DI 10.13703/j.0255-2930.2019.04.009 
PG -296
WC Acupuncture Therapy; Depression; therapy; Humans; Quality of Life; Sertraline; Tablets; Treatment Outcome
UT PubMed:30957448
PM 30957448
DA 2019-04-09
ER

PT J
AU Huang, MC
   Chang, SC
   Liao, WL
   Ke, TW
   Lee, AL
   Wang, HM
   Chang, CP
   Yen, HR
   Chang, HH
   Chen, WT
AF Huang, Ming-Cheng
   Chang, Sheng-Chi
   Liao, Wen-Ling
   Ke, Tao-Wei
   Lee, Ai-Lin
   Wang, Hwei-Ming
   Chang, Che-Pin
   Yen, Hung-Rong
   Chang, Hen-Hong
   Chen, William Tzu-Liang
TI Acupuncture May Help to Prevent Chemotherapy-Induced Peripheral Neuropathy: A 
SO The oncologist
LA English
DT Journal Article
DE acupuncture; chemotherapy; colorectal cancer; oxaliplatin; peripheral neuropathy; prevention
AB OBJECTIVE: This study investigated the efficacy of acupuncture in preventing 
   chemotherapy-induced peripheral neuropathy (CIPN) in patients with colorectal 
   cancer (CRC). METHODS: This single center, randomized, controlled, single-blind 
   clinical trial randomly assigned patients with stage 3 CRC attending outpatient 
   clinics in China Medical University Hospital to either verum or sham acupuncture 
   treatment concurrently with chemotherapy. Primary outcomes were nerve conduction 
   velocity (NCV) and touch thresholds of limb terminals. Secondary outcomes were 
   total and subdomain scores on the Functional Assessment of Cancer Therapy-General 
   (FACT-G), and scores on the FACT/GOG-Ntx subscale and the Brief Pain 
   Inventory-Short Form (BPI-SF), at baseline, weeks 12, 36, and follow-up (week 
   48). RESULTS: Thirty-two patients met the inclusion criteria and received verum 
   acupuncture (N = 16) or sham acupuncture (N = 16). Under the -intent-to-treat 
   principle, 26 participants were analyzed. Significant changes from baseline for 
   questionnaire scores and sensory NCV were observed in both study groups. Sham 
   acupuncture was associated with significant reductions from baseline in motor NCV 
   and sensory touch thresholds; no such changes were observed with verum 
   acupuncture. No serious adverse events were reported. CONCLUSION: Prophylactic 
   acupuncture may exert neuroprotective effects on mechanical or tactile touch 
   thresholds during chemotherapy regimens in patients with CRC, with evidence of 
   this protectiveness persisting at 6 months' follow-up. The lack of change in 
   motor NCV values with verum acupuncture indicates neuroprotective effects. 
   Sensory NCV values and patient-reported outcomes did not differ significantly 
   between the study groups.
C1 Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
   Department of Chinese Medicine, China Medical University Hospital, Taichung, 
   Division of Colorectal Surgery, Department of Surgery, China.
   Medical University Hospital, Taichung, Taiwan.
   Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
   Center for Personalized Medicine, Department of Medical Research, China Medical 
   Division of Colorectal Surgery, Department of Surgery, China.
   Medical University Hospital, Taichung, Taiwan.
   College of Chinese Medicine, China Medical University, Taichung, Taiwan.
   All Ease Traditional Chinese Medicine Clinic, Taichung, Taiwan.
   Department of Surgery, China Medical University Hospital, Taichung, Taiwan.
   Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan.
   Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan.
   School of Chinese Medicine, College of Chinese Medicine, China Medical 
   Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.
   Department of Biotechnology, Asia University, Taichung, Taiwan.
   Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan.
   Graduate Institute of Integrated Medicine, College of Chinese Medicine, China 
   Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.
   Division of Colorectal Surgery, Department of Surgery, China.
   Medical University Hospital, Taichung, Taiwan.
   School of Medicine, Department of Surgery, China Medical University, Taichung, Taiwan.
   Division of Colorectal Surgery, Department of Surgery, China Medical University 
NR 0
TC 0
SN 1549-490
EI 1083-715
J9 Oncologist
PD MAR 28
PY 2023
VL 28
IS 6
BP e436
EP e447
DI 10.1093/oncolo/oyad065 
PG 1
WC Humans; Single-Blind Method; Neuroprotective Agents; adverse effects; Acupuncture Therapy; adverse effects; Peripheral Nervous System Diseases; chemically induced; Antineoplastic Agents; adverse effects
UT PubMed:36971468
PM 36971468
DA 2023-03-28
ER

PT J
AU Su, TF
   Zhao, YQ
   Zhang, LH
   Peng, M
   Wu, CH
   Pei, L
   Tian, B
   Zhang, J
   Shi, J
   Pan, HL
   Li, M
AF Su, T-F
   Zhao, Y-Q
   Zhang, L-H
   Peng, M
   Wu, C-H
   Pei, L
   Tian, B
   Zhang, J
   Shi, J
   Pan, H-L
   Li, M
TI Electroacupuncture reduces the expression of proinflammatory cytokines in 
SO European journal of pain (London, England)
LA English
DT Journal Article
AB Endogenous cannabinoids and peripheral cannabinoid CB2 receptors (CB2Rs) are 
   involved in the antinociceptive effect of electroacupuncture (EA) on inflammatory 
   pain. However, it is not clear how CB2R activation contributes to the 
   antinociceptive effect of EA. The major proinflammatory cytokines, such as tumour 
   necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-6, are involved in 
   inflammatory pain. Here we determined the effects of CB2R activation and EA on 
   the expression level of IL-1β, IL-6 and TNF-α in inflamed skin tissues. 
   Inflammatory pain was induced by injection of complete Freund's adjuvant into the 
   left hindpaw of rats. Thermal hyperalgesia was tested with a radiant heat 
   stimulus, and mechanical allodynia was quantified using von Frey filaments. The 
   mRNA and protein levels of IL-1β, IL-6 and TNF-α in inflamed skin tissues were 
   measured using real-time polymerase chain reaction and Western blot, 
   respectively. Local injection of the selective CB2R agonist AM1241 or EA applied 
   to GB30 and GB34 significantly reduced thermal hyperalgesia and mechanical 
   allodynia induced by tissue inflammation. The specific CB2R antagonist AM630 
   significantly attenuated the antinociceptive effect of EA. Furthermore, EA or 
   AM1241 treatment significantly decreased the mRNA and protein levels of IL-1β, 
   IL-6 and TNF-α in inflamed skin tissues. In addition, pretreatment with AM630 
   significantly reversed the inhibitory effect of EA on these cytokine levels in 
   inflamed skin tissues. Our results suggest that EA reduces inflammatory pain and 
   proinflammatory cytokines in inflamed skin tissues through activation of CB2Rs.
C1 Department of Neurobiology and Key Laboratory of Neurological Diseases of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China.
NR 0
TC 0
SN 1532-214
EI 
J9 Eur J Pain
PD FEB 18
PY 2012
VL 16
IS 5
BP 624
EP 35
DI 10.1002/j.1532-2149.2011.00055.x 
PG -589
WC Animals; Cannabinoids; pharmacology; Electroacupuncture; Hyperalgesia; chemically induced; Indoles; pharmacology; Inflammation; metabolism; Interleukin-1beta; genetics; Interleukin-6; genetics; Male; Pain Management; methods; Pain Measurement; RNA, Messenger; genetics; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; agonists; Skin; drug effects; Tumor Necrosis Factor-alpha; genetics
UT PubMed:22337285
PM 22337285
DA 2012-02-18
ER

PT J
AU Hempen, M
   Hummelsberger, J
AF Hempen, Moritz
   Hummelsberger, Josef
TI The state of evidence in acupuncture: A review of metaanalyses and systematic 
SO Complementary therapies in medicine
LA English
DT Journal Article
DE Acupuncture; Acupuncture effectiveness; Acupuncture evidence; Acupuncture review
AB INTRODUCTION: Over the last decades, acupuncture research has increased 
   drastically. As a result, it has become more and more difficult to oversee the 
   amount of evidence concerning its effect in various medical conditions. Different 
   comparative reviews aimed to roughly assess individual strength of acupuncture 
   evidence, covering the years 2005-2017. Our review intends to assess the level of 
   acupuncture evidence for any medical condition available, concerning the years 
   2017-2022. METHODS: We searched the pubmed database for 'acupuncture' and 
   filtered the results towards systematic reviews and metanalyses (SR/MA). Results 
   were allocated towards medical disciplines and sorted to medical conditions. Each 
   SR/MA was rated concerning quality of review (QoR), quality of data (QoD), and 
   quality of evidence (QoE). To facilitate a rough overview, results were assessed 
   into either of four categories: i) evidence of positive effect, ii) evidence of 
   potential positive effect, iii) insufficient/unclear evidence, iv) no evidence of 
   effect/evidence of no effect. RESULTS: After considering exclusion criteria, 862 
   SR/MA remained for evaluation. Results were allocated and sorted as described, 
   resulting in 184 medical conditions. Of these, in ten medical conditions SR/MA 
   supported evidence of positive effect: chronic pain, low-back pain, knee 
   osteoarthritis, postoperative nausea and vomiting (PONV), migraine, tension-type 
   headache, cancer-related fatigue, menopausal symptoms, female infertility 
   (additional to medical reproductive treatment), chronic prostatitis/chronic 
   pelvic pain syndrome in men. In another 82 medical conditions SR/MA supported 
   evidence of potential positive effect, in another 86 medical conditions SR/MA 
   revealed unclear/insufficient evidence, and in another six medical conditions no 
   evidence of effect/evidence of no effect was found. Compared with previous 
   reviews until the year 2017, the number of medical conditions with higher quality 
   evidence levels has increased, namely evidence of positive effect and evidence of 
   potential positive effect. DISCUSSION AND CONCLUSION: Compared to previous years, 
   the amount and quality of acupuncture evidence has increased in the years 
   2017-2022. In total, 862 included SR/MA resulted in a comparative review of 184 
   medical conditions. Evidence of positive effect was revealed ten medical 
   conditions, another 82 showed evidence of potential positive effect. 86 medical 
   indications showed insufficient evidence for a firm conclusion, six conditions 
   showed no evidence of effect/evidence of no effect. Although general quality of 
   evidence has dramatically increased compared to the previous years, lack of 
   underlying high-quality trials in some cases seems to compromise a consistent 
   comparability between SR/MA. This issue should be addressed for future studies 
   and guidelines such as STRICTA and CONSORT should strictly be obtained.
C1 SMS - International Society for Chinese Medicine, Munich, Germany. 
   SMS - International Society for Chinese Medicine, Munich, Germany.
EM m.hempen@tcm.edu
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD MAR 1
PY 2025
VL 89
IS 
BP 103149
EP 103149
DI 10.1016/j.ctim.2025.103149 
PG 0
WC Acupuncture Therapy; Humans; Systematic Reviews as Topic; Evidence-Based Medicine
UT PubMed:40021024
PM 40021024
DA 2025-03-01
ER

PT J
AU Wang, GX
   Deng, KF
   Liao, ZL
   Zhu, Y
   Chen, RL
AF Wang, Guo-Xiang
   Deng, Kai-Feng
   Liao, Zi-Long
   Zhu, Ying
   Chen, Ri-Lan
TI [Effect of hysteretic acupuncture on joint function and related cytokines in 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Hysteretic acupuncture; Joint function; Knee osteoarthritis; Pain; Randomized controlled trial
AB OBJECTIVE: To observe the difference of therapeutic effect between hysteretic 
   acupuncture and Celecoxib capsules for knee osteoarthritis(KOA), and to 
   investigate their effects on levels of interleukin 6(IL-6) and tumor necrosis 
   factor α(TNF-α) in articular fluid. METHODS: Seventy-two patients with KOA were 
   randomly divided into hysteretic acupuncture and me-dication groups, with 36 
   cases in each group. The patients of the hysteretic acupuncture group received 
   hysteretic acupuncture stimulation at Dubi (ST35), Neixiyan (EX-LE4), Zusanli 
   (ST36), Yanglingquan (GB34), Yinlingquan (SP9), Xuehai (SP10), Liangqiu (ST34) 
   and Heding (EX-LE2) as the main acupoints for 30 min once daily. The patients of 
   the medication group received oral administration of Celecoxib capsules(200 mg) 
   once daily. Both of the two groups were treated with 14 days as a course of 
   treatment, with a 2-day rest between each course of treatment, and the treatments 
   were conducted for 2 courses. The visual analogue scale(VAS) score of pain, 
   Lequesne index score, IL-6 and TNF-α level in joint fluid and the change of 
   traditional Chinese medicine(TCM) syndrome score were observed before and after 
   treatment. RESULTS: Compared with pre-treatment, the VAS score, Lequesne index 
   score, IL-6 and TNF-α level, and total TCM syndrome score decreased significantly 
   after treatment in both of the two groups (P<0.05). Hysteretic acupuncture was 
   more effective in reducing VAS score, Lequesne index score, IL-6 and TNF-α level 
   than Celecoxib capsules (P<0.05), and there was no significant difference in 
   total TCM syndrome score and total effective rate between the two groups(P>0.05). 
   No adverse events occurred in both groups during the treatment. CONCLUSION: 
   Hysteretic acupuncture can effectively relieve pain symptoms and improve joint 
   function in KOA patients. Its effect is comparable to that of oral administration 
   of Celecoxib capsules.
C1 Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China.
   Graduate School of Guangxi University of Chinese Medicine, Nanning 530001.
   Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China.
   Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China.
   Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUL 25
PY 2020
VL 45
IS 7
BP 564
EP 8
DI 10.13702/j.1000-0607.200054 
PG -556
WC Acupuncture Therapy; Cytokines; Humans; Knee Joint; Osteoarthritis, Knee; Treatment Outcome
UT PubMed:32705831
PM 32705831
DA 2020-07-25
ER

PT J
AU Enblom, A
   Johnsson, A
   Hammar, M
   Onelöv, E
   Steineck, G
   Börjeson, S
AF Enblom, A
   Johnsson, A
   Hammar, M
   Onelöv, E
   Steineck, G
   Börjeson, S
TI Acupuncture compared with placebo acupuncture in radiotherapy-induced nausea--a 
SO Annals of oncology : official journal of the European Society for Medical 
LA English
DT Journal Article
AB BACKGROUND: It is not known if verum (real) acupuncture is effective for nausea 
   and vomiting (emesis) during radiotherapy. PATIENTS AND METHODS: We randomly 
   treated 215 blinded cancer patients with verum: penetrating 'deqi' creating 
   acupuncture (n = 109) or non-penetrating sham needles (n = 106) two to three 
   times per week. The patients documented emesis daily during the radiotherapy 
   period. Primary end point was the number of patients with at least one episode of 
   nausea. RESULTS: In the verum and the sham acupuncture group, 70% and 62% 
   experienced nausea at least once during the radiotherapy period (relative risk 
   1.1, 95% CI 0.9-1.4) for a mean number of 10.1 and 8.7 days. Twenty five percent 
   and 28% vomited, and 42% and 37% used antiemetic drugs at least once, 
   respectively. Ninety-five percent in the verum acupuncture group and 96% in the 
   sham acupuncture group believed that the treatment had been effective against 
   nausea. In both groups, 67% experienced positive effects on relaxation, mood, 
   sleep or pain reduction and 89% wished to receive the treatment again. 
   CONCLUSION: Acupuncture creating deqi is not more effective than sham in 
   radiotherapy-induced nausea, but in this study, nearly all patients in both 
   groups experienced that the treatment was effective for nausea.
C1 Division of Nursing Science, Department of Medical and Health Sciences, Linköping University, Linköping
   The Swedish Institute for Health Sciences, LundUniversity, Lund
   Department of Clinical Neuroscience, Osher Centre forIntegrative Medicine, Karolinska Institute, Stockholm. 
   Department of Oncology, University Hospital, Lund.
   Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Linköping University, Linköping.
   Division of Clinical Cancer Epidemiology, Department of Oncology-Pathology, Karolinska Institute, Stockholm.
   Division of Clinical Cancer Epidemiology, Department of Oncology-Pathology, Karolinska Institute, Stockholm
   Division of Clinical Cancer Epidemiology,Department of Oncology, Sahlgrenska Academy, Gothenburg.
   Division of Nursing Science, Department of Medical and Health Sciences, Linköping University, Linköping
   Centre of Surgery and Oncology, Department of Oncology,Linköping University Hospital, Linköping, Sweden.
EM nna.enblom@ki.se
NR 0
TC 0
SN 1569-804
EI 
J9 Ann Oncol
PD SEP 29
PY 2011
VL 23
IS 5
BP 1353
EP 1361
DI 10.1093/annonc/mdr402 
PG 8
WC Acupuncture; methods; Acupuncture Points; Acupuncture Therapy; methods; Adult; Aged; Aged, 80 and over; Algorithms; Female; Humans; Male; Middle Aged; Nausea; etiology; Placebos; Radiotherapy; adverse effects; Single-Blind Method; Young Adult
UT PubMed:21948812
PM 21948812
DA 2011-09-29
ER

PT J
AU Fan, D
   Ren, H
AF Fan, Dihui
   Ren, Hongbin
TI Clinical value of warm acupuncture combined with Jiaji acupoint Tongbian scraping 
SO Medicine
LA English
DT Journal Article
DE Jiaji acupoint Tongbian scraping therapy; myofascial pain syndrome; warm acupuncture; wind-cold-dampness obstruction syndrome
AB This study investigates the clinical value of warm acupuncture combined with 
   Jiaji acupoint Tongbian scraping therapy in patients with myofascial pain 
   syndrome (MPS) of the lumbar and dorsal muscles with wind-cold-dampness 
   obstruction syndrome. A total of 112 patients with wind-cold-dampness 
   obstruction-type MPS admitted to our hospital from January 2024 to October 2024 
   were enrolled. According to different treatment methods, they were assigned into 
   the control group (n = 35, Jiaji acupoint Tongbian scraping therapy), observation 
   group (n = 35, warm acupuncture), and combination group (n = 42, warm acupuncture 
   combined with Jiaji acupoint Tongbian scraping therapy). The following indicators 
   were compared before and after treatment: Traditional Chinese Medicine (TCM) 
   syndrome scores, visual analog scale (VAS) scores, Oswestry Disability Index 
   (ODI) scores, Modified Barthel Index (MBI) scores, serum inflammatory cytokines 
   (interleukin-6, tumor necrosis factor-α, interleukin-1β), clinical efficacy, and 
   incidence of adverse reactions. After treatment, serum inflammatory cytokine 
   levels, TCM syndrome scores, VAS, and ODI scores were significantly lower in the 
   combination group than in the control and observation groups, while the MBI score 
   was significantly higher (F = 22.340, 11.200, 17.130, 40.120, 4.850, 20.960, 
   14.680; P < .05). The overall effective rate in the combination group (95.24%) 
   was significantly higher than that in the control group (74.29%) and the 
   observation group (77.14%) (χ2 = 7.205, P < .05). The incidence of adverse 
   reactions in the combination group (16.67%) showed no significant difference 
   compared with the control group (11.43%) and the observation group (14.29%) 
   (χ2 = 0.428, P > .05). Warm acupuncture combined with Jiaji acupoint Tongbian 
   scraping therapy can effectively improve clinical symptoms and functional 
   impairment, reduce pain and inflammatory levels, and enhance activities of daily 
   living, without significantly increasing adverse reactions. This combined 
   approach demonstrates high clinical efficacy.
C1 Department of Acupuncture and Moxibustion, Jiaxing Traditional Chinese Medicine Hospital, Jiaxing, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD DEC 30
PY 2025
VL 104
IS 52
BP e46161
EP e46161
DI 10.1097/MD.0000000000046161 
PG 1
WC Humans; Male; Female; Acupuncture Therapy; methods; Myofascial Pain Syndromes; therapy; Acupuncture Points; Middle Aged; Adult; Treatment Outcome; Pain Measurement; Medicine, Chinese Traditional; methods; Combined Modality Therapy; Lumbosacral Region
UT PubMed:41465915
PM 41465915
DA 2025-12-30
ER

PT J
AU Chen, Y
   Song, H
   Chen, M
   Xu, H
AF Chen, Yuqin
   Song, Huaihua
   Chen, Mingyu
   Xu, Hua
TI The role of acupotomy in treatment of patients with lumbar spinal stenosis: A 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: Currently, there is some clinical evidence supporting the use of 
   acupuncture in alleviating pain and dysfunction in patients with lumbar spinal 
   stenosis (LSS). However, the question of whether acupuncture could be efficacious 
   for ageing patients remains unanswered. We designed a randomized controlled study 
   to evaluate the safety and feasibility of acupuncture for participants with 
   symptomatic LSS. METHODS: This study is a randomized, single-blind, 
   noninferiority trial. This clinical trial was approved by the Linyi Cancer 
   Hospital. We received informed consent from all patients before surgery. In 
   preparing this report, we adhered to the Consolidated Standards of Reporting 
   Trials guidelines. We randomized consented study participants on a 1:1 ratio to 
   one of two study groups (acupuncture and control groups) using a 
   computer-generated list of random numbers in varying block sizes. Three outcome 
   measures were selected to evaluate the effectiveness and safety of the treatment: 
   visual analogue score and Oswestry disability index, and complicatins. A P < .05 
   was regarded as statistically significant. RESULTS: The hypothesis was that the 
   acupuncture group would achieve acceptable clinical outcomes as compared to the 
   control group in LSS. TRIAL REGISTRATION: This study protocol was registered in 
   Research Registry (researchregistry5744).
C1 Department of Rehabilitation, Linyi Central Hospital.
   Department of Obstetrics and Gynecology, The third People's Hospital of Linyi.
   Department of Neurology, Linyi Central Hospital.
   Department of Bone Oncology, Linyi Cancer Hospital, Shandong, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD AUG 7
PY 2020
VL 99
IS 31
BP e21444
EP e21444
DI 10.1097/MD.0000000000021444 
PG 1
WC Aged; Aged, 80 and over; Humans; Middle Aged; Acupuncture Therapy; methods; Case-Control Studies; Feasibility Studies; Lumbar Vertebrae; diagnostic imaging; Magnetic Resonance Imaging; methods; Outcome Assessment, Health Care; Safety; Single-Blind Method; Spinal Stenosis; therapy; Treatment Outcome; Visual Analog Scale; Randomized Controlled Trials as Topic; Equivalence Trials as Topic
UT PubMed:32756160
PM 32756160
DA 2020-08-07
ER

PT J
AU Shi, HX
   Gao, YJ
   Wang, SR
AF Shi, Hao-Xin
   Gao, Yu-Jun
   Wang, Shu-Ren
TI Electroacupuncture in non-surgical management of lumbar spinal stenosis: 
SO Frontiers in immunology
LA English
DT Review
DE electroacupuncture; inflammation; ligamentum flavum thickening; lumbar spinal stenosis; signal pathway
AB Lumbar Spinal Stenosis (LSS) is a prevalent spinal disorder mainly induced by 
   degenerative changes in the spine, which lead to nerve root compression. This 
   results in symptoms such as lower back pain, numbness of the lower limbs, and 
   difficulty in walking. The thickening of the ligamentum flavum (LF) is a crucial 
   pathological feature of LSS and is closely linked to inflammatory responses. 
   Electroacupuncture (EA), a form of traditional Chinese medical therapy, has 
   garnered increasing recognition in modern medicine in recent years. It has shown 
   notable efficacy in alleviating pain and enhancing function. EA achieves these 
   effects by modulating inflammatory cytokines, reducing pro-inflammatory markers 
   such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1le, and 
   interleukin-6 (IL-6), while increasing anti-inflammatory cytokines like 
   interleukin-10 (IL-10). Additionally, EA may inhibit LF thickening by suppressing 
   signaling pathways, specifically the nuclear factor-κB (NF-κB) pathway, the Janus 
   kinase/signal transducer and activator of transcription (JAK/STAT) pathway, and 
   the mitogen-activated protein kinase (MAPK) pathway. Clinical studies indicate 
   that when EA is combined with other treatment modalities, it can significantly 
   reduce pain and improve functional status in patients with LSS, thus enhancing 
   their quality of life. Although the mechanisms underlying the effects of EA in 
   the treatment of LSS warrant further exploration, its ability to regulate 
   inflammatory responses through multiple pathways and promote tissue repair 
   provides new perspectives and directions for the non-surgical management of LSS. 
   This review encapsulates the application of EA in LSS and explores its potential 
   mechanisms in mitigating LF thickening through the modulation of inflammatory 
   cytokines. The aim is to offer a reference for future research and clinical 
   practice.
C1 Graduate School, Heilongjiang University of Chinese Medicine, Harbin, China.
   Graduate School, Heilongjiang University of Chinese Medicine, Harbin, China.
   Department of Traditional Orthopedic Therapy, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
NR 0
TC 0
SN 1664-322
EI 
J9 Front Immunol
PD NOV 17
PY 2025
VL 16
IS 
BP 1644394
EP 1644394
DI 10.3389/fimmu.2025.1644394 
PG 0
WC Humans; Electroacupuncture; methods; Spinal Stenosis; therapy; Ligamentum Flavum; pathology; Cytokines; metabolism; Animals; Inflammation Mediators; metabolism; Lumbar Vertebrae; pathology; Signal Transduction
UT PubMed:41246317
PM 41246317
DA 2025-11-17
ER

PT J
AU Wei, J
   Yang, Z
   Lin, Q
   Xu, H
   Lai, F
   Han, Y
   Li, J
   Cui, S
AF Wei, Jinqiang
   Yang, Zihong
   Lin, Qiutian
   Xu, Haiyan
   Lai, Fang
   Han, Yun
   Li, Jun
   Cui, Shuai
TI Bibliometric and visualized analysis of electroacupuncture in the past 10 years.
SO Complementary therapies in medicine
LA English
DT Journal Article
DE CiteSpace; Cooperation; Electroacupuncture; Research status
AB BACKGROUND: There are many studies that have interrogated the evolution and use 
   of electroacupuncture (EA). We aimed to evaluate the research status, cooperation 
   and development of EA in the past 10 years. METHODS: We obtained data on the EA 
   from the Web of Science core collection database. CiteSpace 5.7. R1 software was 
   used to assess research cooperation through analysis of authors, institutions and 
   countries. In addition, keyword cluster analysis, references and burst detection 
   were analyzed to explore research hotspots and trends in the field of EA. 
   RESULTS: We included a total of 3019 citing literature and 78,235 cited 
   literature for analysis. The data showed that there has been a rise in the global 
   number of EA studies in the past decade. Besides, the data demonstrated that 
   China has made outstanding contribution in the development of EA. Whereas there 
   is inter-agency cooperation in China, there is less cooperation with other 
   countries. In addition, we showed frequent use of keywords such as "expression", 
   "stimulation", or "pain". Besides, neuroscience was the main research area, 
   followed by general medicine and oncology. Furthermore, with the improved 
   research methods and technologies, there is enhanced overall quality of the 
   studies. CONCLUSION: Taken together, our findings demonstrate a steady increase 
   in the studies involving EA. However, the studies are unevenly distributed among 
   countries and thus there is need for closer international cooperation.
C1 The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
   The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
   The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
   The Seventh Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
   The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China
   The Second Affiliated Hospital of Guangzhou University ofChinese Medicine, Guangzhou, China
   Chao En-Xiang Famous Chinese Medicine ExpertInheritance Studio, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou,Guangdong, China. 
   The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China
   The Second Affiliated Hospital of Guangzhou University ofChinese Medicine, Guangzhou, China
   Chao En-Xiang Famous Chinese Medicine ExpertInheritance Studio, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou,Guangdong, China.
   The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China
   The Second Affiliated Hospital of Guangzhou University ofChinese Medicine, Guangzhou, China.
   Research Institute of Acupuncture and Meridian, Anhui University of Chinese Medicine, Hefei, China
   South China Research Center for Acupuncture &Moxibustion, Medical College of Acupuncture-Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine, Guangzhou, China.
EM 13016090@qq.com
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD JUN 11
PY 2022
VL 69
IS 
BP 102846
EP 102846
DI 10.1016/j.ctim.2022.102846 
PG 0
WC Bibliometrics; China; Electroacupuncture; Humans; Publications; Software
UT PubMed:35688327
PM 35688327
DA 2022-06-11
ER

PT J
AU Fu, YB
   Li, B
   Sun, SF
   Liu, HL
   Wang, X
   Wang, SS
   Zhang, F
   Du, X
   Ge, DJ
   Shang, L
   Liang, RL
   Wang, LN
   Yuan, F
   Sun, JQ
   Chen, JW
AF Fu, Yuan-Bo
   Li, Bin
   Sun, San-Feng
   Liu, Hui-Lin
   Wang, Xin
   Wang, Shao-Song
   Zhang, Fan
   Du, Xin
   Ge, Du-Juan
   Shang, Lei
   Liang, Rui-Li
   Wang, Li-Na
   Yuan, Fang
   Sun, Jing-Qing
   Chen, Jun-Wei
TI Fire acupuncture for mild to moderate knee osteoarthritis: a protocol for a 
SO Trials
LA English
DT Journal Article
DE Basic health management; Fire Acupuncture; Knee Osteoarthritis
AB BACKGROUND: Knee osteoarthritis (KOA) is one of the most common bone and joint 
   diseases. As one of the main non-drug therapies, acupuncture is widely used to 
   treat KOA, although the evidence for its efficacy is inconclusive. The objective 
   of this pilot trial is to clarify the clinical efficacy and safety of fire 
   acupuncture in the treatment of mild to moderate KOA and to provide high-quality 
   data for further research. METHODS/DESIGN: This study is a prospective randomized 
   controlled pilot trial in which 120 patients with mild to moderate KOA will be 
   randomly allocated in equal proportions to a fire acupuncture group or a general 
   acupuncture group. They will receive acupuncture for six sessions over 2 weeks. 
   The primary end point is success rate, which will be calculated based on the 
   change from baseline of the pain and function scores in the Western Ontario and 
   McMaster Universities Osteoarthritis Index at 4 weeks. Secondary end points 
   include the proportion of patients achieving clinical improvement based on: (1) 
   the OMERACT-OARSI responder criteria, (2) levels of matrix metalloproteinase 3, 
   interleukin 1β, and tumor necrosis factor α in blood, and (3) a subjective 
   efficacy evaluation from patients. TRIAL REGISTRATION: Chinese Clinical Trial 
   Registry, ChiCTR1800019162. Registered on 29 October 2018.
C1 The Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory ofAcupuncture Neuromodulation, No. 23 Meishuguanhou Street, Dongcheng District,Beijing, 100010, China.
   Beijing Huairou District Hospital of Traditional Chinese Medicine, No. 1 Houheng 
   The Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory ofAcupuncture Neuromodulation, No. 23 Meishuguanhou Street, Dongcheng District,Beijing, 100010, China.
   Beijing Huairou District Hospital of Traditional Chinese Medicine, No. 1 Houheng Street, Huairou District, Beijing, 101400, China.
   The Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory ofAcupuncture Neuromodulation, No. 23 Meishuguanhou Street, Dongcheng District,Beijing, 100010, China.
   The Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory ofAcupuncture Neuromodulation, No. 23 Meishuguanhou Street, Dongcheng District,Beijing, 100010, China.
   The Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory ofAcupuncture Neuromodulation, No. 23 Meishuguanhou Street, Dongcheng District,Beijing, 100010, China.
   The Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory ofAcupuncture Neuromodulation, No. 23 Meishuguanhou Street, Dongcheng District,Beijing, 100010, China.
   The Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory ofAcupuncture Neuromodulation, No. 23 Meishuguanhou Street, Dongcheng District,Beijing, 100010, China.
   Beijing Huairou District Hospital of Traditional Chinese Medicine, No. 1 Houheng Street, Huairou District, Beijing, 101400, China.
   Beijing Huairou District Hospital of Traditional Chinese Medicine, No. 1 Houheng Street, Huairou District, Beijing, 101400, China.
   Beijing Huairou District Hospital of Traditional Chinese Medicine, No. 1 Houheng Street, Huairou District, Beijing, 101400, China.
   Beijing Huairou District Hospital of Traditional Chinese Medicine, No. 1 Houheng Street, Huairou District, Beijing, 101400, China.
   The Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory ofAcupuncture Neuromodulation, No. 23 Meishuguanhou Street, Dongcheng District,Beijing, 100010, China.
   The Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory ofAcupuncture Neuromodulation, No. 23 Meishuguanhou Street, Dongcheng District,Beijing, 100010, China. sjqdoctor@163.com.
   The Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory ofAcupuncture Neuromodulation, No. 23 Meishuguanhou Street, Dongcheng District,Beijing, 100010, China. 847431304@qq.com.
   Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang 
NR 0
TC 0
SN 1745-621
EI 
J9 Trials
PD DEC 6
PY 2019
VL 20
IS 1
BP 673
EP 673
DI 10.1186/s13063-019-3744-2 
PG 0
WC Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Acupuncture Therapy; methods; Osteoarthritis, Knee; therapy; Pilot Projects; Prospective Studies; Randomized Controlled Trials as Topic; Research Design; Multicenter Studies as Topic
UT PubMed:31801600
PM 31801600
DA 2019-12-06
ER

PT J
AU Liu, T
   Zhi, W
   Wang, X
   Pei, Q
   Guo, X
   Huang, Q
AF Liu, Tong
   Zhi, Wenqian
   Wang, Xiaoquan
   Pei, Qian
   Guo, Xianfeng
   Huang, Qiang
TI Effectiveness of Fu's subcutaneous needling on pain and physical function in 
SO Complementary therapies in medicine
LA English
DT Journal Article
DE Fu's subcutaneous needling; Inflammatory cytokines; Knee osteoarthritis; Meta-analysis; Pain assessment; Randomized controlled trials
AB OBJECTIVES: This study aims to evaluate the efficacy of Fu's subcutaneous 
   needling (FSN) for knee osteoarthritis (KOA) via a meta-analysis. METHODS: 
   Randomized controlled trials (RCTs) of FSN for KOA were searched in PubMed, 
   Cochrane Library, Embase, Web of Science, and other databases up to July 20, 
   2024. Stata 15.0 was leveraged for data analysis. RESULTS: 30 RCTs were included, 
   involving 2169 individuals. Compared to electroacupuncture, acupuncture, and 
   other therapies, FSN demonstrated significant benefits in reducing the Western 
   Ontario and McMaster Universities Arthritis Index score (WOMAC, improved physical 
   function) [SMD= -1.69 (-2.15 to -1.23), I² = 89.8 %, P < 0.001] and relieving 
   pain (the visual analog scale) [SMD = -1.77( -2.14 to -1.40); I² = 89.8 %, 
   P < 0.001]. Additionally, FSN was more effective in reducing inflammatory 
   cytokine levels, such as interleukin 1β [SMD = -1.65 (-2.36, -0.94); I² = 91.9 %, 
   P < 0.001], interleukin-6 [SMD = -3.93 (-5.08, -2.78); I² = 96.7 %, P < 0.001], 
   and tumor necrosis factor-α [SMD = -2.65 (-3.46, -1.83); I² = 94.8 %, P < 0.001], 
   and increasing the total effective rate [OR = 4.17, 95 % CI: 3.05-5.68; I² 
   = 0.0 %, P < 0.001]. CONCLUSIONS: FSN shows promise as an adjuvant therapy for 
   KOA, with moderate-quality evidence supporting its short-term efficacy in pain 
   relief and functional improvement. Further validation through standardized 
   protocols is required to determine its long-term benefits.
C1 Department of Rehabilitation Medicine, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing,China.
   Department of Rehabilitation Medicine, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing,China.
   Department of Rehabilitation Medicine, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing,China.
   Department of Rehabilitation Medicine, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing,China.
   Department of Rehabilitation Medicine, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing,China.
   Department of Rehabilitation Medicine, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing,China. 
EM hq2349@vip.sina.com
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD AUG 23
PY 2025
VL 93
IS 
BP 103233
EP 103233
DI 10.1016/j.ctim.2025.103233 
PG 0
WC Humans; Osteoarthritis, Knee; therapy; Acupuncture Therapy; methods; Randomized Controlled Trials as Topic; Pain Management; methods
UT PubMed:40846208
PM 40846208
DA 2025-08-23
ER

PT J
AU Li, SK
   Fan, YX
   Cao, XW
   Zhao, J
   Zhu, S
   Liu, ZQ
AF Li, Shao-Kang
   Fan, Yuan-Xiao
   Cao, Xiao-Wen
   Zhao, Jie
   Zhu, Sen
   Liu, Zhi-Qing
TI [Effect of administration of acupuncture stimulation combined with Gushen Zhuyu 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acupuncture; Apoptosis; Lumbar disc herniation; Traditional Chinese medicine
AB OBJECTIVE: To investigate the therapeutic effect of acupuncture stimulation 
   combined with administration of"Gushen Zhuyu Tang"(decoction for consolidating 
   kidney to eliminate blood stasis, DCKEBS) in the treatment of lumbar disc 
   herniation (LDH) patients. METHODS: A total of 147 patients with LDH were 
   randomly divided into DCKEBS, acupuncture and DCKEBS+acupuncture groups (n= 49 
   cases in each group). The patients of the acupuncture group received a) 
   acupuncture stimulation of Dazhui (GV14), Ganshu (BL18), Shenshu (BL23), Tianshu 
   (ST25), Yanglingquan (GB34), etc., b) fire needle pricking of the topical 
   tendons, cord-like points, tender-points, c) row-needles stimulation of the 
   attachment sites of muscles of the sacroiliac joint or crista iliaca, and d) 
   acupotomy-debonding of the topical high-tension muscles, twice a week for 4 
   weeks. Those patients of the DCKEBS group were ordered to take DCKEBS [containing 
   fried Yiyiren (Semen Coicis), Shanzhuyu (Fructus Corni), fried Baizhu (Rhizoma 
   Astractylodis), Sangjisheng (Ramulus Loranthi), Duzhong (Cortex Eucommiae), 
   Buguzhi (Fructus Psoraieae), etc.] 150 mL, twice daily, continuously for 4 weeks, 
   and those of the DCKEBS+acupuncture group received the combined treatment 
   mentioned above in the acupuncture and DCKEBS groups. The pain severity was 
   assessed by using visual ana-logue scale (VAS, 0-10 points) and the modified 
   Japan Orthopaedic Association questionnaire (M-JOA) score (0-30 points), 
   separately, and the lumbar range of motion (ROM) and lumbar muscle strength were 
   tested to evaluate the lumbar motor function. The levels of serum tumor necrosis 
   factor α(TNF-α), matrix metalloproteinase-2 (MMP-2), and apoptosis related 
   factors Caspase-3 and Caspase-9 were assayed using ELISA. The total effective 
   rates of the three groups were compared. RESULTS: After the treatment, the VAS 
   and M-JOA scores, contents of serum TNF-α, MMP-2, Caspase-3 and Caspase-9 were 
   significantly decreased (P<0.01), and the myodynamia of lumbar muscular flexor 
   and extensor was considerably increased (P<0.01) in the three groups, and the ROM 
   angles of lumbar extending and buckling were increased (P<0.01) in the 
   DCKEBS+acupuncture group compared with pretreatment. Comparison among the 3 
   groups showed that the VAS and M-JOA scores, and serum TNF-α, MMP-2, Caspase-3 
   and Caspase-9 contents of the DCKEBS+acupuncture group were significantly lower 
   than those of both DCKEBS and acupuncture groups (P<0.01), while the ROM angles 
   of lumbar extending and buckling, and the myodynamia of lumbar muscular flexor 
   and extensor were obviously higher in the DCKEBS+acupuncture group than those of 
   the DCKEBS and acupuncture groups (P<0.01). The total effective rate was 
   93.88%(46/49) in the DCKEBS+acupuncture group, higher than 75.51%(37/49) in the 
   DCKEBS group and 71.43%(35/49) in the acupuncture group (P<0.05). CONCLUSION: 
   Acupuncture combined with DCKEBS can relieve pain, improve lumbar muscle strength 
   and lumbar movement function, and reduce serum TNF-α, MMP-2, Caspase-3 and 
   Caspase-9 levels in LDH patients.
C1 Department of Acupuncture and Moxibustion, Gongli Hospital, Pudong New Area, Shanghai 200135, China.
   Department of Acupuncture and Moxibustion, Gongli Hospital, Pudong New Area, Shanghai 200135, China.
   Department of Acupuncture and Moxibustion, Gongli Hospital, Pudong New Area, Shanghai 200135, China.
   Department of Acupuncture and Moxibustion, Gongli Hospital, Pudong New Area, Shanghai 200135, China.
   Department of Acupuncture and Moxibustion, Gongli Hospital, Pudong New Area, Shanghai 200135, China.
   Department of Acupuncture and Moxibustion, Gongli Hospital, Pudong New Area, Shanghai 200135, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD OCT 28
PY 2022
VL 47
IS 10
BP 907
EP 13
DI 10.13702/j.1000-0607.20210951 
PG -894
WC Humans; Intervertebral Disc Displacement; therapy; Matrix Metalloproteinase 2; Caspase 9; Caspase 3; Tumor Necrosis Factor-alpha; Treatment Outcome; Acupuncture Therapy; Acupuncture Points
UT PubMed:36301169
PM 36301169
DA 2022-10-28
ER

PT J
AU Qiu, JQ
   Liu, SR
   Lin, QL
   Li, MJ
   Zhuang, JX
   Wu, GW
AF Qiu, Jian-Qing
   Liu, Shu-Ru
   Lin, Qian-Lin
   Li, Ming-Jing
   Zhuang, Jing-Xiang
   Wu, Guang-Wen
TI [Acupuncture combined with cinesiotherapy cupping for knee osteoarthritis with qi 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture; cinesiotherapy; cupping; knee osteoarthritis (KOA); randomized controlled trial (RCT)
AB OBJECTIVE: To compare the clinical efficacy between acupuncture combined with 
   cinesiotherapy cupping and acupuncture combined with conventional cupping for 
   knee osteoarthritis (KOA) with qi stagnation and blood stasis syndrome, and to 
   seek a better solution for KOA. METHODS: A total of 78 patients of KOA with qi 
   stagnation and blood stasis syndrome were randomly divided into an observation 
   group and a control group, 39 cases in each group (3 cases in the observation 
   group and 2 cases in the control group lost contact). Both groups were treated 
   with acupuncture at Neixiyan (EX-LE 4), Dubi (ST 35), Xuehai (SP 10), Liangqiu 
   (ST 34), Heding (EX-LE 2), Zusanli (ST 36), Yinlingquan (SP 9), Yanglingquan (GB 
   34) and Xuanzhong (GB 39). Based on the acupuncture treatment, the control group 
   was treated with conventional cupping. The No. 4 cupping glass was used for 
   Xuehai (SP 10), Liangqiu (ST 34) and Fengshi (GB 31), while the No. 3 cupping 
   glass was used for Yinlingquan (SP 9), while the cupping with appropriate size 
   was used for ashi points; the cupping glass was retained for 5 min. Based on the 
   acupuncture treatment, the observation group was treated with cinesiotherapy 
   cupping. The selection of acupoint and cupping glass was identical as the control 
   group. The patients were instructed to perform knee flexion-extension, hip 
   abduction-adduction, weight-bearing and other active exercise while cupping; the 
   treatment was given once a day, 10 times as a course of treatment; totally three 
   courses were given with an interval of 2 days between the courses. The patient's 
   symptom scores, pain scores and knee function scores were recorded before and 
   after treatment. The amount of joint effusion was measured by ultrasound; the 
   level of interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α 
   (TNF-α) in joint effusion were measured by ELISA. RESULTS: After treatment, the 
   total effective rate in the observation group was 94.4% (34/36), which was 
   significantly higher than 86.5% (32/37) in the control group (P<0.05). Compared 
   before treatment, the symptom scores, pain scores, amount of joint effusion and 
   the levels of IL-1, IL-6, TNF-α in joint fluid in both groups all were decreased 
   after treatment, whereas the knee function scores were increased (P<0.05). 
   Compared with the control group, the symptom scores, pain scores, and the levels 
   of IL-1, TNF-α and the amount of joint effusion all were significantly decreased, 
   whereas the knee function scores were increased in the observation group 
   (P<0.05). The level of IL-6 in joint effusion was not significantly different 
   between the observation group and the control group (P>0.05). CONCLUSION: The 
   acupuncture combined with cinesiotherapy cupping could alleviate pain, improve 
   joint function and reduce joint effusion, which is superior to acupuncture 
   combined with conventional cupping.
C1 School of Acupuncture and Moxibustion, Fujian University of TCM, Fuzhou 350122, China.
   School of Acupuncture and Moxibustion, Fujian University of TCM, Fuzhou 350122, China.
   the Third People's Hospital Affiliated to Fujian University of TCM, Fuzhou 350000.
   the Third People's Hospital Affiliated to Fujian University of TCM, Fuzhou 350000.
   the Third People's Hospital Affiliated to Fujian University of TCM, Fuzhou 350000.
   the Third People's Hospital Affiliated to Fujian University of TCM, Fuzhou 350000
   Academy of Integrated Chinese and Western Medicine, Fujian University ofTCM, Fuzhou 350122
   Fujian Provincial Key Laboratory of Integrated Chinese andWestern Medicine on Geriatrics, Fuzhou 350122.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAY 18
PY 2019
VL 39
IS 5
BP 462
EP 6
DI 10.13703/j.0255-2930.2019.05.002 
PG -456
WC Acupuncture Therapy; Humans; Knee Joint; Osteoarthritis, Knee; therapy; Qi; Treatment Outcome
UT PubMed:31099214
PM 31099214
DA 2019-05-18
ER

PT J
AU Mallory, MJ
   Croghan, KA
   Sandhu, NP
   Lemaine, V
   Degnim, AC
   Bauer, BA
   Cha, SS
   Croghan, IT
AF Mallory, Molly J
   Croghan, Katrina A
   Sandhu, Nicole P
   Lemaine, Valerie
   Degnim, Amy C
   Bauer, Brent A
   Cha, Stephen S
   Croghan, Ivana T
TI Acupuncture in the postoperative setting for breast cancer patients: a 
SO The American journal of Chinese medicine
LA English
DT Journal Article
DE Acupuncture; Breast Cancer; Breast Reconstruction; Feasibility; Mastectomy; Postsurgical; Quality of Life
AB Acupuncture is used to treat a variety of symptoms and conditions associated with 
   cancer and cancer treatments. The present study was performed to evaluate the 
   feasibility of providing acupuncture in the hospital setting for breast cancer 
   patients and to evaluate the short-term effect of acupuncture on stress, anxiety, 
   and pain. This was an open label study conducted at Mayo Clinic Hospital, 
   Methodist and Saint Marys Campus, Rochester, Minnesota. A total of 20 adult 
   breast cancer patients undergoing mastectomy and/or breast reconstruction were 
   recruited and offered daily acupuncture intervention beginning postoperative day 
   1 and continuing for the duration of the hospital stay. Outcome measures included 
   the Symptom Visual Analog Scale (VAS) and Satisfaction Question and 
   Was-it-Worth-it (WIWI) Questionnaire. It was found that acupuncture is a feasible 
   option for postoperative breast cancer patients. In addition, it can 
   significantly decrease the levels of anxiety (p = 0.0065), tension/muscular 
   discomfort (p < 0.001) and pain (p = 0.023). The association between acupuncture 
   and relaxation was found to be statistically borderline (p = 0.053). This 
   feasibility study showed that acupuncture can be integrated into a busy 
   postsurgical clinical practice. These results also suggest that acupuncture may 
   be an important intervention in the postoperative setting for breast cancer 
   patients.
C1 Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
NR 0
TC 0
SN 1793-685
EI 
J9 Am J Chin Med
PD FEB 17
PY 2015
VL 43
IS 1
BP 45
EP 56
DI 10.1142/S0192415X15500032 
PG 11
WC Acupuncture; Adult; Anxiety; therapy; Breast Neoplasms; psychology; Feasibility Studies; Female; Humans; Mastectomy; Middle Aged; Pain, Postoperative; therapy; Postoperative Care; Quality of Life; Plastic Surgery Procedures; Stress, Psychological; therapy; Treatment Outcome
UT PubMed:25682785
PM 25682785
DA 2015-02-17
ER

PT J
AU Stringer, J
   Ryder, WD
   Mackereth, PA
   Misra, V
   Wardley, AM
AF Stringer, Jacqui
   Ryder, W David
   Mackereth, Peter A
   Misra, Vivek
   Wardley, Andrew M
TI A randomised, pragmatic clinical trial of ACUpuncture plus standard care versus 
SO European journal of oncology nursing : the official journal of European Oncology 
LA English
DT Journal Article
DE Acupuncture; Chemotherapy induced peripheral neuropathy; Controlled trial
AB PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose limiting 
   toxicity posing a major clinical challenge for managing patients receiving 
   specific chemotherapy regimens (e.g., Taxanes). There is a growing body of 
   literature suggesting acupuncture can improve CIPN symptoms. The purpose of the 
   ACUFOCIN trial was to collect preliminary data on the safety, feasibility, 
   acceptability and initial effectiveness of acupuncture as a treatment for CIPN, 
   comparing use of acupuncture plus standard care (Acupuncture) against standard 
   care alone (Control). METHOD: At a tertiary cancer centre, a pragmatic, 
   randomised, parallel group design study was used to investigate the effectiveness 
   of a 10-week course of acupuncture. Participants experiencing CIPN of ≥ Grade II, 
   recording a 'Most Troublesome' CIPN symptom score of ≥3 using the "Measure 
   Yourself Medical Outcome Profile" (MYMOP 2), were randomised to 'Acupuncture' or 
   'Control' arms. Clinicians were blinded to allocated groups, however as it was 
   not possible to blind participants, it cannot be guaranteed they did not disclose 
   study allocation within their clinic assessments. The primary outcome measure was 
   the number of patients reporting a ≥ 2-point improvement (success) in their 
   MYMOP2 score at week 10. 100 participants (120 to allow for attrition) were 
   required for a hypothesised improvement in success proportions from 30% to 55% 
   using a primary analysis model with logistic regression adjusted for 
   stratification factors and baseline MYMOP2 scores. Feasibility and acceptability 
   of study design was addressed through percentage return of primary outcome, 
   retention rate and a nested qualitative study. RESULTS: Primary MYMOP2 outcome 
   data at week 10 was available for 108/120 randomised participants; this is 
   greater than the 100 participants required to adequately power the study. There 
   were 36/53 (68%) successes in 'Acupuncture' compared to 18/55 (33%) in 'Control'. 
   Beneficial effects were seen in the secondary outcome data, including clinicians' 
   grading of neuropathy, EORTC, QLQ-CIPN20, QLQ-C30 summary scores and patient 
   reported pain scores. There were no serious adverse events reported within the 
   study and only 16 acupuncture associated events, none of which required 
   intervention. CONCLUSION: A 10-week course of acupuncture resulted in measurable 
   improvement in participants symptoms of CIPN. The results warrant further 
   investigation.
C1 The Christie NHS Foundation Trust, Wilmslow Rd, Manchester, M20 4BX, UK
   School of Medical Sciences, Faculty of Biology, Medicine and Health, The University ofManchester, Oxford Road, Manchester, M13 9PL, UK. 
   Manchester Clinical Trials Unit, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK. Electronicaddress: david.ryder@manchester.ac.uk.
   The Christie NHS Foundation Trust, Wilmslow Rd, Manchester, M20 4BX, UK. 
   The Christie NHS Foundation Trust, Wilmslow Rd, Manchester, M20 4BX, UK. 
   School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK
   Outreach Research& Innovation Group, Adamson House, Ground Floor, Towers Business Park, WilmslowRoad, Didsbury, M20 2YY, UK. 
EM ndrew.Wardley@Outreach-Research-Innovation.com
NR 0
TC 0
SN 1532-212
EI 1462-388
J9 Eur J Oncol Nurs
PD AUG 12
PY 2022
VL 60
IS 
BP 102171
EP 102171
DI 10.1016/j.ejon.2022.102171 
PG 0
WC Acupuncture Therapy; adverse effects; Antineoplastic Agents; adverse effects; Humans; Peripheral Nervous System Diseases; chemically induced; Quality of Life; Research Design; Taxoids; adverse effects
UT PubMed:35952460
PM 35952460
DA 2022-08-12
ER

PT J
AU Greenlee, H
   Crew, KD
   Capodice, J
   Awad, D
   Jeffres, A
   Unger, JM
   Lew, DL
   Hansen, LK
   Meyskens, FL Jr
   Wade, JL 3rd
   Hershman, DL
AF Greenlee, Heather
   Crew, Katherine D
   Capodice, Jillian
   Awad, Danielle
   Jeffres, Anne
   Unger, Joseph M
   Lew, Danika L
   Hansen, Lisa K
   Meyskens, Frank L Jr
   Wade, James L 3rd
   Hershman, Dawn L
TI Methods to Standardize a Multicenter Acupuncture Trial Protocol to Reduce 
SO Journal of acupuncture and meridian studies
LA English
DT Journal Article
DE acupuncture; aromatase inhibitor; breast cancer; clinical trial; multisite; randomized controlled trial
AB Robust methods are needed to efficiently conduct large, multisite, randomized, 
   controlled clinical trials of acupuncture protocols. The Southwest Oncology Group 
   (SWOG) S1200 trial is a randomized, controlled (i.e., sham-controlled and 
   waitlist-controlled) trial of a standardized acupuncture protocol for treating 
   aromatase inhibitor (AI)-associated arthralgias in early-stage breast cancer 
   patients (n = 228). The primary objective of this study was to determine whether 
   true acupuncture administered twice weekly for 6 weeks, as compared to sham 
   acupuncture or a waitlist control, reduced AI-associated joint pain at 6 weeks as 
   assessed by patient reports. The study was conducted at 11 institutions across 
   the United States. The true acupuncture protocol was developed using a 
   consensus-based process. The true acupuncture and the sham acupuncture protocols 
   each consisted of 12 sessions administered for 6 weeks, followed by one weekly 
   session for 6 weeks. The true acupuncture protocol used standardized protocol 
   points, and the standardized acupoints were tailored to a patient's joint 
   symptoms. The similarly standardized sham acupuncture protocol utilized 
   superficial needling of nonacupoints. Standardized methods were developed to 
   train and monitor acupuncturists and included online and in-person training, 
   study manuals, monthly phone calls, and remote quality assurance monitoring 
   throughout the study period. The research staff similarly received online and 
   in-person training and monthly phone calls.
C1 Columbia University Medical Center, New York, USA. 
   Columbia University Medical Center, New York, USA.
   Mount Sinai Medical Center, New York, USA.
   Columbia University Medical Center, New York, USA.
   Columbia University Medical Center, New York, USA.
   SWOG Statistical Center/Fred Hutchinson Cancer Research Center, Seattle, USA.
   SWOG Statistical Center/Fred Hutchinson Cancer Research Center, Seattle, USA.
   Legacy Health System, Portland, USA.
   University of California at Irvine, Orange, USA.
   Cancer Care Specialists of Central Illinois/Heartland NCORP, Decatur, USA.
   Columbia University Medical Center, New York, USA.
EM hg2120@columbia.edu
NR 0
TC 0
SN 2093-815
EI 2005-290
J9 J Acupunct Meridian Stud
PD JUN 24
PY 2015
VL 8
IS 3
BP 152
EP 8
DI 10.1016/j.jams.2015.03.006 
PG -144
WC Aromatase Inhibitors; adverse effects; Arthralgia; etiology; Breast Neoplasms; drug therapy; Female; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; standards
UT PubMed:26100070
PM 26100070
DA 2015-06-24
ER

PT J
AU Qu, J
   Peng, Y
   Shen, X
   Xiong, J
   Wang, H
   Xiao, X
   Wang, Y
AF Qu, Jinyu
   Peng, Yingchun
   Shen, Xuefang
   Xiong, Jin
   Wang, Huan
   Xiao, Xiang
   Wang, Yili
TI Electroacupuncture of Guanyuan (CV4) Acupoint Improved Pelvic Inflammatory 
SO Immunity, inflammation and disease
LA English
DT Journal Article
DE Guanyuan acupoint; electroacupuncture; neuroinflammation; pelvic inflammatory disease; sympathetic activity
AB OBJECTIVE: To investigate the underlying mechanisms through which 
   electroacupuncture (EA) at the Guanyuan (CV4) acupoint inhibits sympathetic 
   activity and neurogenic inflammatory responses to relieve pain in rats with 
   pelvic inflammatory disease (PID). METHODS: Escherichia coli and Staphylococcus 
   aureus were used to establish a PID rat model. EA was evaluated at frequencies of 
   2, 100, and 2/100 Hz, and 2/100 Hz was selected for subsequent investigation. The 
   rats were randomly divided into the control, model, EA-guanyuan (2/100 Hz), and 
   EA-nonsensitized groups (n = 6). Mechanical withdrawal threshold (MWT) and 
   thermal withdrawal latency (TWL) were assessed using von Frey filaments. 
   Hematoxylin and eosin staining was performed to evaluate the histopathology. The 
   tyrosine hydroxylase (TH) expression was analyzed using immunofluorescence (IF) 
   staining. The levels of tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), 
   transforming growth factor-β1 (TGF-β1), intercellular cell adhesion molecule-1 
   (ICAM-1), 5-hydroxytryptamine receptor 3 (5-HT3R), substance P (SP), hyaluronic 
   acid (HA), and bradykinin (BK) were measured using an enzyme-linked immunosorbent 
   assay (ELISA). Western blot analysis was performed to measure the expression of 
   5-HT3R, calcitonin gene-related peptide (CGRP), HA, Kininogen 1 (KNG1), 
   prostaglandin I2 (PGI2), and trefoil factor 2 (TFF2). Transmission electron 
   microscopy (TEM) was used to observe synaptic connections. RESULTS: EA at CV4 
   reduced the behavioral pain score (p < 0.05), increased MWT and TWL, and 
   alleviated uterine tissue pathological damage in rats. EA at CV4 reduced the 
   levels of 5-HT3R, CGRP, BK, HA, KNG1, PGI2SP, TGF-β1, ICAM-1, and TNF-α, and 
   increased IL-2 levels (p < 0.05). Furthermore, EA at CV4 inhibited sympathetic 
   activity by decreasing TH expression (p < 0.05). Additionally, EA at CV4 restored 
   the synaptic connections between the pelvic nerves of the dorsal commissural 
   neuron (DCN). CONCLUSION: EA at CV4 alleviated the pathological damage and pain 
   sensitization of uterine tissue in rats with PID by inhibiting sympathetic 
   activity and neurogenic inflammatory response.
C1 Department of Neurology, the First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
   Department of Neurology, the First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
   Department of Neurology, the First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
   Department of Neurology, the First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
   Department of Rehabilitation Medicine, the First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
   Department of Nephrology, First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
   Department of Rehabilitation Medicine, the First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
NR 0
TC 0
SN 2050-452
EI 
J9 Immun Inflamm Dis
PD NOV 6
PY 2025
VL 13
IS 11
BP e70299
EP e70299
DI 10.1002/iid3.70299 
PG 1
WC Humans; Pelvic Inflammatory Disease; pathology; Neuroinflammatory Diseases; therapy; Sympathetic Nervous System; Animals; Rats; Disease Models, Animal; Pain Management; Acupuncture Points; Female; Rats, Sprague-Dawley; Uterus; pathology; Chromosome Pairing; Acupuncture Therapy
UT PubMed:41194515
PM 41194515
DA 2025-11-06
ER

PT J
AU Jiang, YY
   Li, X
   Hu, FX
   Wang, DN
   Zang, JM
   Liu, ZL
   Xu, F
   Cui, WQ
AF Jiang, Yi-Yang
   Li, Xue
   Hu, Feng-Xian
   Wang, Dan-Ni
   Zang, Ji-Miao
   Liu, Zhen-Ling
   Xu, Fei
   Cui, Wen-Qiang
TI Electroacupuncture alleviates chemotherapy-induced peripheral neuropathy and 
SO Neuroscience
LA English
DT Journal Article
DE Anxiety; Chemotherapeutic neuropathy; Cisplatin; Electroacupuncture; Paraventricular thalamic nucleus
AB Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and 
   dose-limiting side effect of neurotoxic cancer treatments, generally alongside 
   anxiety disorders. The paraventricular thalamic nucleus (PVT), as an integrative 
   node of sensory perceptions and emotional reactions, remains unclear in CIPN 
   modulation. This study aimed to investigate the role of PVT in CIPN and reveal 
   the mechanisms through which electroacupuncture (EA) alleviates CIPN. In this 
   study, a CIPN mouse model with emotional disorders was established through the 
   intervention of cisplatin for 21 d, which was validated by the von Frey test, 
   adhesive removal test, open-field test and elevated plus-maze test. Data showed 
   that the cisplatin-related CIPN was characterized by the increase of calcium 
   channel proteins TRPC6 and PKC, as well as the activation of glutamatergic 
   neurons in PVT. Inhibition of TRPC6 and PKC using SAR7334 significantly hindered 
   sensory neuron damage and the loss of intra-epidermal nerve fibers (IENFs) and 
   Merkel cells, while improving anxiety-like behaviors. EA treatment ameliorated 
   the symptoms of CIPN, including neuropathic pain, impairment of cutaneous 
   sensation, and loss of IENFs and Merkel cells in the acral skin, which exhibited 
   similar effects of SAR7334. Mechanically, EA treatment significantly inhibited 
   TRPC6 activation, reducing the Ca(2+) influx and attenuating p-PKC level, thereby 
   decreasing the release of excitatory neurotransmitter glutamate in the PVT. Our 
   findings revealed a novel mechanism through which calcium influx-mediated 
   glutamatergic neuron activation in PVT participated in the CIPN and provided 
   evidence that TRPC6/PKC may be potent targets for the EA effect.
C1 The First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
   School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
   The First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
   The First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
   The First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
   The First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
   Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
   Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China. 
EM qcui16@fudan.edu.cn
NR 0
TC 0
SN 1873-754
EI 
J9 Neuroscience
PD NOV 26
PY 2025
VL 592
IS 
BP 97
EP 110
DI 10.1016/j.neuroscience.2025.11.031 
PG 13
WC Animals; Electroacupuncture; methods; Anxiety; therapy; Male; Protein Kinase C; metabolism; Mice; Peripheral Nervous System Diseases; chemically induced; Midline Thalamic Nuclei; metabolism; Glutamic Acid; metabolism; TRPC6 Cation Channel; metabolism; Neurons; metabolism; Disease Models, Animal; Antineoplastic Agents; toxicity; Mice, Inbred C57BL
UT PubMed:41290068
PM 41290068
DA 2025-11-26
ER

PT J
AU Avery, EC
   Augustine, H
   Sade, S
   Dengler, J
AF Avery, Emma Claire
   Augustine, Haley
   Sade, Shachar
   Dengler, Jana
TI Extradigital glomus tumour of the thigh causing 8 years of undiagnosed 
SO BMJ case reports
LA English
DT Journal Article
DE Pain; Plastic and reconstructive surgery; Radiology
AB A woman in her mid-50s was referred to a plastic surgeon with an 8-year history 
   of undiagnosed, localised severe, reproducible pain of the right thigh. Treatment 
   with oral and topical analgesics, corticosteroids, acupuncture and physiotherapy 
   did not provide symptom relief. She was referred to multiple specialists over the 
   preceding 8 years including chronic pain physicians, physiatry, orthopaedic 
   surgery and plastic surgery. Investigations including sonographic and MRI 
   eventually revealed a non-specific soft tissue abnormality in the area of 
   tenderness, which was excised en bloc. Histopathology revealed an extradigital 
   glomus tumour. The patient's symptoms immediately and permanently resolved 
   postexcision.Physicians seeing patients suffering from undiagnosed focal, 
   reproducible pain should consider extradigital glomus tumours in their 
   differential diagnosis. Workup for extradigital glomus tumour includes focused 
   sonographic or MRI over the area of pain. Additionally, local injection of an 
   anaesthetic agent can be used to assist with diagnosis.
C1 Plastic, Reconstructive and Aesthetic Surgery, University of Toronto, Toronto, Ontario, Canada.
   Plastic, Reconstructive and Aesthetic Surgery, University of Toronto, Toronto, Ontario, Canada.
   Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
   Plastic, Reconstructive and Aesthetic Surgery, University of Toronto, Toronto, Ontario, Canada jana.dengler@mail.utoronto.ca.
   Division of Plastic and Reconstructive Surgery, Tory Trauma Program, Sunnybrook 
NR 0
TC 0
SN 1757-790
EI 
J9 BMJ Case Rep
PD DEC 20
PY 2022
VL 15
IS 12
BP 
EP 
DI 10.1136/bcr-2022-249869 
PG 0
WC Female; Humans; Glomus Tumor; surgery; Thigh; pathology; Ultrasonography; Magnetic Resonance Imaging; Chronic Pain
UT PubMed:36535730
PM 36535730
DA 2022-12-20
ER

PT J
AU Axelsson, CK
   Ballegaard, S
   Karpatschof, B
   Schousen, P
AF Axelsson, Christen K
   Ballegaard, Søren
   Karpatschof, Benny
   Schousen, Peer
TI Pressure pain sensitivity as a marker for stress and pressure pain 
SO Scandinavian journal of clinical and laboratory investigation
LA English
DT Journal Article
DE Acupuncture; EORTC questionnaire; HADS questionnaire; SF 36 questionnaire; acupressure; clinical stress score; patient education; self-evaluated stress
AB OBJECTIVES: To validate (1) Pressure Pain Sensitivity (PPS) as a marker for 
   stress and (2) a PPS-guided intervention in women with primary Breast Cancer 
   (BC). METHODS: (1) A total of 58 women with BC were examined before and after 6 
   months of intervention. A control group of 165 women office employees was divided 
   in a High Stress Group (HSG, n = 37) and a Low Stress Group (LSG, n = 128) to 
   evaluate the association between PPS, questionnaire-related Quality of Life (QOL) 
   and self-evaluated stress. (2) A PPS-guided stress management program (n = 40) 
   was compared to a Psychosocial Group Intervention (PGI, n = 91) and no treatment 
   (n = 86) with respect to a European Organization for Research and Treatment of 
   Cancer (EORTC) questionnaire measured QOL. RESULTS: (1) Resting PPS and changes 
   in PPS during the intervention period correlated significantly to EORTC and Short 
   Form 36 (SF 36) main scores: (all p < 0.05). Between BC, HSG and LSG there was a 
   significant and positive correlation with respect to PPS, SF 36 main scores, 
   depression, and clinical stress scores (all p < 0.05). However, the BC group 
   scored significantly lower than both HSG and LSG (both p < 0.05) with respect to 
   self-evaluated stress. (2) The PPS-guided intervention group improved EORTC main 
   score, pain and nausea, when compared to the control groups (all p < 0.05). 
   CONCLUSIONS: PPS was positively associated with QOL, which was in contrast to 
   self-evaluated stress. PPS-guided intervention improved QOL in women with breast 
   cancer.
C1 Department of Breast Surgery, Herlev Hospital, Herlev, University of Copenhagen , Denmark.
NR 0
TC 0
SN 1502-768
EI 
J9 Scand J Clin Lab Invest
PD APR 5
PY 2014
VL 74
IS 5
BP 399
EP 407
DI 10.3109/00365513.2014.900187 
PG 8
WC Breast Neoplasms; physiopathology; Case-Control Studies; Cross-Sectional Studies; Disease Management; Female; Humans; Male; Pain Threshold; Patient Compliance; Pressure; Quality of Life; Stress, Psychological; diagnosis; Surveys and Questionnaires
UT PubMed:24697620
PM 24697620
DA 2014-04-05
ER

PT J
AU Deng, G
AF Deng, Gary
TI Integrative Medicine Therapies for Pain Management in Cancer Patients.
SO Cancer journal (Sudbury, Mass.)
LA English
DT Review
AB Pain management for cancer patients should include pharmacologic and 
   nonpharmacologic interventions. Integrative medicine therapies, such as mind-body 
   practice, acupuncture, massage therapy, and music therapy, have been studied for 
   their roles in pain management. Data from randomized controlled trials support 
   the effect of hypnosis, acupuncture, and music therapy in reduction of pain. 
   Mindfulness meditation, yoga, qigong, and massage therapy, although may not 
   reduce pain per se, can relieve anxiety and mood changes, which are commonly 
   associated with pain. In clinical practice, one should also consider burdens and 
   risks to patients, patient preference, and the presence or absence of better 
   alternatives when making decisions on whether an integrative medicine therapy is 
   of clinical value.
C1 From the Memorial Sloan Kettering Cancer Center, New York, NY.
NR 0
TC 0
SN 1540-336
EI 1528-911
J9 Cancer J
PD OCT 1
PY 2019
VL 25
IS 5
BP 343
EP 348
DI 10.1097/PPO.0000000000000399 
PG 5
WC Acupuncture; Cancer Pain; etiology; Combined Modality Therapy; Complementary Therapies; Disease Management; Humans; Integrative Medicine; methods; Mind-Body Therapies; methods; Neoplasms; complications; Pain Management
UT PubMed:31567462
PM 31567462
DA 2019-10-01
ER

PT J
AU Zhao, JY
   Yuan, GM
   Li, PY
   Wang, XM
   Liu, ZX
   Xu, Y
   Guo, YM
   Li, Y
AF Zhao, Ji-Yu
   Yuan, Gong-Ming
   Li, Pei-Yun
   Wang, Xin-Meng
   Liu, Zi-Xuan
   Xu, Yuan
   Guo, Yong-Ming
   Li, Yuan
TI [Effects of acupuncture on the efferocytosis pathway of Mer receptor tyrosine 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acupuncture; Adjuvant arthritis; Efferocytosis; Mer receptor tyrosine kinase
AB OBJECTIVES: To observe the effect of acupuncture at "Zusanli" (ST36) on the 
   expression of Mer receptor tyrosine kinase (MerTK)-related efferocytosis 
   regulatory molecules in mice with adjuvant arthritis induced by complete Freund's 
   adjuvant (CFA), so as to explore the potential mechanism of acupuncture on 
   efferocytosis in adjuvant arthritis. METHODS: C57BL/6J mice were randomly divided 
   into a saline group, a model group, and an acupuncture group (10 mice/group). The 
   right hind footpad of mice in the saline group was injected with 0.9% sodium 
   chloride solution, while those in the model group and the acupuncture group were 
   injected with CFA (50 μL) to establish the model of adjuvant arthritis. Mice in 
   the acupuncture group received acupuncture at bilateral ST36 once a day for a 
   total of 7 times, and mice in the saline group and the model group were fixed in 
   the same way. During the experiment, paw swelling degree and the paw withdrawal 
   thermal latency (PWTL) of mice were measured before modeling, on the day of 
   modeling (D0) and on the 1(st), 3(rd), 5(th) and 7(th) day of acupuncture (D1, 
   D3, D5, D7) to evaluate paw swelling and pain conditions. The mRNA expressions of 
   tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β in spinal cord 
   tissue were detected by real-time quantitative PCR. The protein expressions of 
   MerTK, phosphorylated (p)-signal transducer and activator of transcription 3 
   (STAT3), STAT3, and programmed death-ligand 1 (PD-L1) in footpad and spinal cord 
   tissue were detected by Western blot. RESULTS: After modeling, compared with the 
   saline group, the PWTL on D0-D7, the protein expression of PD-L1 in spinal cord 
   and protein expressions of MerTK and PD-L1 in footpad, the phosphorylation level 
   of STAT3 in spinal cord and footpad were decreased (P<0.01) in the model group, 
   while the degree of paw swelling, mRNA expressions of TNF-α, IL-6, and IL-1β in 
   spinal cord tissue were increased (P<0.01, P<0.05). Compared with the model 
   group, the PWTL on D1-D7, the protein expressions of MerTK, PD-L1 and 
   phosphorylation level of STAT3 in spinal cord and footpad were increased (P<0.01) 
   in the acupuncture group after acupuncture intervention, while the degree of paw 
   swelling on D7, the mRNA expressions of TNF-α, IL-6, and IL-1β in spinal cord 
   tissue were significantly decreased(P<0.01, P<0.05). CONCLUSIONS: Acupuncture can 
   improve the symptoms of mice with adjuvant arthritis, which may be related to 
   promoting MerTK-mediated efferocytosis and thus exerting an anti-inflammatory 
   effect.
C1 Research Center of Experimental Acupuncture, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   School of Acupuncture-Moxibustion and Tuina & Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing 210023.liyuan@njucm.edu.cn.
   Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, 
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD SEP 18
PY 2025
VL 50
IS 9
BP 1021
EP 1028
DI 10.13702/j.1000-0607.20240585 
PG 7
WC Animals; Mice; Mice, Inbred C57BL; Humans; c-Mer Tyrosine Kinase; genetics; Acupuncture Therapy; Male; Arthritis, Experimental; therapy; Acupuncture Points; Interleukin-1beta; genetics; Receptor Protein-Tyrosine Kinases; genetics; Tumor Necrosis Factor-alpha; genetics; Female; STAT3 Transcription Factor; genetics; Interleukin-6; genetics; Efferocytosis
UT PubMed:40962725
PM 40962725
DA 2025-09-18
ER

PT J
AU Hurlow, A
   Bennett, MI
   Robb, KA
   Johnson, MI
   Simpson, KH
   Oxberry, SG
AF Hurlow, Adam
   Bennett, Michael I
   Robb, Karen A
   Johnson, Mark I
   Simpson, Karen H
   Oxberry, Stephen G
TI Transcutaneous electric nerve stimulation (TENS) for cancer pain in adults.
SO The Cochrane database of systematic reviews
LA English
DT Journal Article
AB BACKGROUND: Cancer-related pain is complex and multi-dimensional but the mainstay 
   of cancer pain management has predominantly used a biomedical approach. There is 
   a need for non-pharmacological and innovative approaches. Transcutaneous Electric 
   Nerve Stimulation (TENS) may have a role in pain management but the effectiveness 
   of TENS is currently unknown. This is an update of the original review published 
   in Issue 3, 2008. OBJECTIVES: The aim of this systematic review was to determine 
   the effectiveness of TENS for cancer-related pain in adults. SEARCH METHODS: The 
   initial review searched The Cochrane Library, MEDLINE, EMBASE, CINAHL, PsychINFO, 
   AMED and PEDRO databases in April 2008. We performed an updated search of 
   CENTRAL, MEDLINE, EMBASE, CINAHL and PEDRO databases in November 2011. SELECTION 
   CRITERIA: We included only randomised controlled trials (RCTS) investigating the 
   use of TENS for the management of cancer-related pain in adults. DATA COLLECTION 
   AND ANALYSIS: The search strategy identified a further two studies for possible 
   inclusion. One of the review authors screened each abstract using a study 
   eligibility tool. Where eligibility could not be determined, a second author 
   assessed the full paper. One author used a standardised data extraction sheet to 
   collect information on the studies and independently assess the quality of the 
   studies using the validated five-point Oxford Quality Scale. The small sample 
   sizes and differences in patient study populations of the three included studies 
   (two from the original review and a third included in this update) prevented 
   meta-analysis. For the original review the search strategy identified 37 possible 
   published studies; we divided these between two pairs of review authors who 
   decided on study selection; all four review authors discussed and agreed final 
   scores. MAIN RESULTS: Only one additional RCT met the eligibility criteria (24 
   participants) for this updated review. Although this was a feasibility study, not 
   designed to investigate intervention effect, it suggested that TENS may improve 
   bone pain on movement in a cancer population. The initial review identified two 
   RCTs (64 participants) therefore this review now includes a total of three RCTs 
   (88 participants). These studies were heterogenous with respect to study 
   population, sample size, study design, methodological quality, mode of TENS, 
   treatment duration, method of administration and outcome measures used. In one 
   RCT, there were no significant differences between TENS and placebo in women with 
   chronic pain secondary to breast cancer treatment. In the other RCT, there were 
   no significant differences between acupuncture-type TENS and sham in palliative 
   care patients; this study was underpowered. AUTHORS' CONCLUSIONS: Despite the one 
   additional RCT, the results of this updated systematic review remain inconclusive 
   due to a lack of suitable RCTs. Large multi-centre RCTs are required to assess 
   the value of TENS in the management of cancer-related pain in adults.
C1 Palliative Care Team, Leeds Teaching Hospitals NHS Trust, Leeds, UK. adamhurlow@yahoo.co.uk.
NR 0
TC 0
SN 1469-493
EI 
J9 Cochrane Database Syst Rev
PD MAR 16
PY 2012
VL 2012
IS 3
BP CD006276
EP CD006276
DI 10.1002/14651858.CD006276.pub3 
PG 1
WC Adult; Bone Diseases; therapy; Humans; Neoplasms; complications; Pain; etiology; Pain Management; methods; Randomized Controlled Trials as Topic; Transcutaneous Electric Nerve Stimulation; methods
UT PubMed:22419313
PM 22419313
DA 2012-03-16
ER

PT J
AU Lee, RP
AF Lee, Ru-Ping
TI [Storing Complementary Therapy Knowledge to Expand Nursing Roles].
SO Hu li za zhi The journal of nursing
LA chi
DT Journal Article
AB Incorporating complementary therapy into nursing care is common in clinical 
   practice. Complementary therapy is a non-pharmacological approach used to help 
   address symptoms that cannot be alleviated entirely by medication. These 
   complementary therapies often serve specific purposes, and nurses are the ideal 
   candidates to administer them due to their patient care expertise. However, 
   before applying any complementary therapy, it is essential to understand the 
   potential medical safety, ethical, and legal considerations involved in the 
   therapeutic process. Furthermore, administrators should strengthen their 
   knowledge and implementation of these therapies to ensure safety during use. 
   Complementary therapy facilitates the management of symptoms that are not 
   manageable by medication alone. For example, aromatherapy and light therapy are 
   employed in clinical settings to alleviate anxiety, depression, insomnia, and 
   pain (Farrar & Farrar, 2020; Fong et al., 2023), while acupuncture, acupressure, 
   and qigong are utilized to relieve pain in cancer patients (Behzadmehr et al., 
   2020). Although complementary therapy is gradually gaining acceptance in clinical 
   practice for mitigating patient discomfort, it has yet to achieve widespread 
   adoption, with the culture within healthcare institutions and the attitudes of 
   healthcare professionals being significant factors influencing adoption 
   willingness. Research findings indicate that the primary factor influencing the 
   use of complementary therapy by nurses is lack of relevant knowledge (Siedlecki, 
   2021). Elements of complementary therapy have been incorporated into the 
   blueprint of the National Council Licensure Examination - Registered Nurse in 
   Western countries. Thus, nursing education programs in the United States are now 
   required to integrate complementary therapy into their curricula (Helms, 2006). 
   The above emphasizes the importance of equipping nursing professionals with 
   crucial knowledge and skills related to complementary therapy. When integrated 
   appropriately and safely into patient care, complementary therapy not only 
   enhances the quality and status of nursing but also demonstrates the 
   irreplaceable role of nurses in assisting patients manage symptoms that are not 
   fully manageable by medication alone. As modern medical technology and treatment 
   modalities continue to grow in complexity, nursing professionals must maintain an 
   open-minded perspective and be willing to adapt to and learn the diverse 
   knowledge and skills required in today's era of interdisciplinary. Implementing 
   complementary therapy requires relevant healthcare knowledge for symptom relief 
   as well as familiarity with the related principles and skills. Complementary 
   therapy often involves more extended contact with the recipients of care, making 
   it safer and more appropriate when administered by nursing professionals who have 
   received medical training. In this column, three articles discuss common 
   complementary therapeutic practices such as aromatherapy, the non-invasive 
   Chinese medicine meridian-and-acupoint intervention, and light therapy. Each 
   article introduces the principles of these therapies and their application in 
   nursing. It is hoped that the information provided on these three complementary 
   therapies will help nursing professionals find reference points for expanding and 
   strengthening their interdisciplinary nursing practices. Thus, the inherent 
   advantages of the nursing profession may be leveraged to further enhance and 
   implement the professional nursing process and to maximize the roles and 
   capabilities of the nursing profession.
C1 PhD, RN, Professor, Institute of Medical Sciences, Tzu Chi University, Taiwan, ROC. fish@gms.tcu.edu.tw.
NR 0
TC 0
SN 
EI 0047-262
J9 Hu Li Za Zhi
PD NOV 20
PY 2023
VL 70
IS 6
BP 4
EP 5
DI 10.6224/JN.202312_70(6).01 
PG 1
WC Humans; Complementary Therapies; Aromatherapy; Psychotherapy; Acupuncture Points; Anxiety
UT PubMed:37981877
PM 37981877
DA 2023-11-20
ER

PT J
AU Lu, L
   Huang, X
   Liu, C
   Wang, X
   Lv, J
AF Lu, Lingyun
   Huang, Xianhao
   Liu, Ci
   Wang, Xiaoyu
   Lv, Jianqin
TI Perioperative intradermal acupuncture reduces postoperative nausea and vomiting 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE PC6; intradermal acupuncture; metabolomics; postoperative nausea and vomiting; randomized controlled trial
AB BACKGROUND: The aim of this study was to evaluate the impact of intradermal 
   acupuncture (IA) at PC6 on postoperative nausea and vomiting (PONV) following 
   cerebellopontine angle tumor resection, and to investigate possible mechanisms of 
   action. METHODS: Seventy patients scheduled for elective craniotomy were 
   randomized into IA or sham IA (Sham) groups, with interventions applied 1 h 
   before surgery and continued for 24 h postoperatively. Co-primary outcomes were 
   the incidence of vomiting at 0-6 h and 6-24 h post-surgery. Secondary outcomes 
   included the incidence of nausea and pain intensity. Electrogastrography (EGG) 
   and heart rate variability (HRV) were used to assess gastric activity and 
   autonomic nerve function, respectively. Untargeted metabolomic analysis of serum 
   and cerebrospinal fluid (CSF) was also performed. RESULTS: The incidence of 
   vomiting at 6-24 h (but not 0-6 h) post-surgery was significantly lower in the IA 
   group (12.1%) compared to the Sham group (36.4%; p = 0.022). IA significantly 
   reduced the incidence of nausea at 0-6 h (48.5% vs 78.8%; p = 0.011) but not 
   6-24 h. HRV analysis showed a higher HF component in the IA group post-surgery. 
   Metabolomic analyses revealed significant changes in multiple metabolites and 
   pathways in serum and CSF. CONCLUSION: IA stimulation at PC6 effectively reduced 
   postoperative vomiting at 6-24 h following cerebellopontine angle tumor resection 
   and may also reduce early nausea (at 0-6 h). The mechanisms of action underlying 
   these effects potentially include modulation of vagus nerve activity and 
   regulation of metabolic pathways. TRIAL REGISTRATION NUMBER: ChiCTR2100049992 
   (Chinese Clinical Trial Registry).
C1 Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China.
   Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China.
   Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China.
   Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
   Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD NOV 28
PY 2025
VL 43
IS 6
BP 330
EP 343
DI 10.1177/09645284251399690 
PG 13
WC Humans; Female; Male; Postoperative Nausea and Vomiting; therapy; Middle Aged; Acupuncture Therapy; Adult; Cerebellopontine Angle; surgery; Aged; Acupuncture Points
UT PubMed:41310932
PM 41310932
DA 2025-11-28
ER

PT J
AU Hempen, CH
   Hummelsberger, J
AF Hempen, Carl-Hermann
   Hummelsberger, Josef
TI [Traditional Chinese medicine (TCM)-what is myth and what is the state of 
SO Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
LA ger
DT Review
DE Acupuncture; Chinese herbal medicine; Chinese medicine; Evidence; TCM
AB Traditional Chinese medicine (TCM) is the most comprehensive and widely practiced 
   system of medicine in the world.Originally, TCM appeared in our Western context 
   as an unfathomable mythological doctrine. Once the linguistic barriers had been 
   overcome, it became possible to understand and apply the terminological and 
   physiological concepts, the method of diagnosis, and the clinical findings.Since 
   the NIH consensus conference in 1998, our understanding of TCM has been the 
   subject of methodologically robust studies. We now have evidence of the efficacy 
   and effectiveness of acupuncture beyond its use in pain therapy and allergy 
   treatment. Thanks to fMRI studies, among others, we also have a better 
   understanding of the mechanisms underlying acupuncture.Meta-analyses and studies 
   also confirm the efficacy of Chinese medicinal drugs and remedies in some fields, 
   yet there is still extensive need for further research. But opportunities are 
   also emerging for new medicines and prescriptions for (accompanying) treatments 
   of infections, autoimmune diseases, cancer, metabolic illnesses, dermatological 
   disorders, and gastrointestinal diseases.To enable further evaluation of TCM, but 
   also to ensure an integrative, critical application in the practice of TCM, it is 
   vital for doctors to have thorough training. Further institutionalisation is 
   necessary to provide orientation and patient safety.The days of regarding TCM as 
   some kind of mysticism are indeed long over and it can offer real opportunities 
   for better patient care. In many fields, there is increasing evidence of TCM's 
   effectiveness, yet further comprehensive research is essential. This should be 
   encouraged unconditionally.
C1 Technische Universität München, Georg-Brauchle-Ring 62, 80992, München, Deutschland. ch@hempen.de.
   , München, Deutschland.
NR 0
TC 0
SN 1437-158
EI 
J9 Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
PD APR 9
PY 2020
VL 63
IS 5
BP 570
EP 576
DI 10.1007/s00103-020-03132-9 
PG 6
WC Acupuncture Therapy; Drugs, Chinese Herbal; Germany; Humans; Medicine, Chinese Traditional; methods; Pain Management; methods
UT PubMed:32266491
PM 32266491
DA 2020-04-09
ER

PT J
AU Duc, Nguyen M
   Van, Tran T
   Vinh, Nguyen Q
   Doan, Ha C
   Vu, Phuong Dang L
AF Duc Nguyen, Minh
   Van Tran, Thanh
   Vinh Nguyen, Quoc
   Doan Ha, Cay
   Vu Phuong Dang, Linh
TI Effectiveness of bee venom acupuncture for patients suffering from periarthritis 
SO Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
LA English
DT Journal Article
DE bee venom acupuncture; inflammatory cytokines; periarthritis humeroscapularis; range of motion, articular; shoulder function score; visual analogue scale
AB OBJECTIVE: To evaluate the efficacy of bee venom acupuncture in humeroscapularis 
   (PHS) patients. METHODS: One hundred and twenty patients diagnosed with PHS were 
   assigned into four groups: BV1 (0.01 mg/kg), BV2 (0.005 mg/kg), BV3 (0.0025 
   mg/kg), and control group (vitamin B1 plus novocain 3% injection) with 15 d of 
   treatment. The outcomes of the study including visual analogue scale (VAS) score 
   and β-endorphin, inflammatory cytokines including interleukin-10 (IL-10), IL-1β 
   and tumor necrosis factor α (TNF-α) and shoulder function score were assessed at 
   baseline, after 10 and 15 d of treatment. RESULTS: All four groups reported 
   statistically significant improvement in VAS score, motion range, and shoulder 
   function score ( < 0.01), only the BV3 group showed significant increase of 
   anti-inflammatory (IL-10) and decrease of pro-inflammatory (IL-1β, TNF-α) 
   cytokines after treatment ( < 0.05). The BV3 group presented a significant 
   difference between all outcomes compared to the control and other groups. 
   CONCLUSION: BV3 groups showed better recovery including reduced pain, improved 
   motor function and normalized inflammatory cytokines than current therapy used in 
   Vietnam and other groups.
C1 Senior Specialist Clinic, National Hospital of Acupuncture, Hanoi 1000, Vietnam.
   Department of Senior Specialist National Hospital of Acupuncture, Hanoi 1000, Vietnam.
   Department of Senior Specialist, Military Institute of Traditional Medicine, Hanoi 1000, Vietnam.
   Department of minimally invasive spine, National Hospital of Acupuncture, Hanoi 1000, Vietnam.
   Department of Medicine, Dai Nam University, Hanoi 1000, Vietnam.
NR 0
TC 0
SN 2589-451
EI 0255-292
J9 J Tradit Chin Med
PD JUL 16
PY 2023
VL 43
IS 4
BP 795
EP 800
DI 10.19852/j.cnki.jtcm.2023.04.002 
PG 5
WC Humans; Periarthritis; therapy; Interleukin-10; Tumor Necrosis Factor-alpha; Bee Venoms; therapeutic use; Acupuncture Therapy; Cytokines
UT PubMed:37454265
PM 37454265
DA 2023-07-16
ER

PT J
AU Yang, GS
   Kim, HJ
   Griffith, KA
   Zhu, S
   Dorsey, SG
   Renn, CL
AF Yang, Gee Su
   Kim, Hee Jun
   Griffith, Kathleen A
   Zhu, Shijun
   Dorsey, Susan G
   Renn, Cynthia L
TI Interventions for the Treatment of Aromatase Inhibitor-Associated Arthralgia in 
SO Cancer nursing
LA English
DT Journal Article
AB BACKGROUND: Aromatase inhibitors (AIs) have been established as successful 
   adjuvant therapy for breast cancer survivors. Unfortunately, nearly half of women 
   taking AIs report joint pain, AI-associated arthralgia (AIA). Aromatase 
   inhibitor-associated arthralgia often results in noncompliance, which could lead 
   to cancer recurrence. OBJECTIVE: The purpose of this study was to identify 
   current pain management of AIA and to evaluate the study quality and effects of 
   interventions. METHODS: Nineteen articles published from 2000 to August 2015 were 
   identified using PubMed, CINAHL, PsycINFO, Web of Science, and additional 
   records. Study quality was evaluated by the Quality Assessment Tool for 
   Quantitative Studies. Meta-analysis was used to obtain effect sizes of 
   interventions on pain and subgroups. RESULTS: Five types of interventions 
   emerged: pharmacological approaches, acupuncture, nutritional supplementation, 
   relaxation techniques, and physical exercise. Six studies were strong, 8 were 
   moderate, and 5 were weak in quality. The overall effect size of the 
   interventions on pain was large; pharmacological approaches, acupuncture, and 
   relaxation techniques showed moderate to large effects on pain, whereas 
   nutritional supplementation and physical exercise had no significant effects on 
   it. CONCLUSION: The evidence was based on a body of research with moderate study 
   quality. Although the overall effect of interventions is large, further 
   investigation into the influence of nutrition and physical exercise is needed to 
   better discern their potential for pain management. IMPLICATION FOR PRACTICE: 
   Oncology nurses may be able to implement such validated interventions as pain 
   management modalities to mitigate the symptoms so that breast cancer survivors 
   remain compliant with AIA therapy.
C1 Author Affiliations: Departments of Pain and Translational Symptom Science (Ms Yang and Drs Kim, Griffith, Dorsey, and Renn) and Organizational Systems andAdult Health (Dr Zhu), University of Maryland School of Nursing, Baltimore.
NR 0
TC 0
SN 1538-980
EI 
J9 Cancer Nurs
PD JUN 23
PY 2016
VL 40
IS 4
BP E26
EP E41
DI 10.1097/NCC.0000000000000409 
PG 1
WC Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Female; Humans; Randomized Controlled Trials as Topic; Survivors; Treatment Outcome
UT PubMed:27333128
PM 27333128
DA 2016-06-23
ER

PT J
AU Shu, W
   Ran, JC
   Chen, BL
   Li, CN
   Ruan, SQ
   Hou, WG
AF Shu, Wen
   Ran, Jin-Chuan
   Chen, Bing-Li
   Li, Chao-Nan
   Ruan, Shuo-Quan
   Hou, Wen-Guang
TI [Acupuncture at xing-spring point, shu-stream point and lower he-sea point for 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture; back-shu point; lower he-sea point; shu-stream point; type-2 diabetic peripheral neuropathy; xing-spring point
AB OBJECTIVE: To observe the effect of acupuncture at xing-spring point, shu-stream 
   point and lower he-sea point on neurological function and clinical symptoms in 
   patients with type-2 diabetic peripheral neuropathy. METHODS: Sixty patients with 
   type-2 diabetic peripheral neuropathy were randomly divided into an observation 
   group and a control group, 30 cases in each one. Both groups were treated with 
   basic treatment, and the observation group was additionally treated with 
   acupuncture at Neiting (ST 44), Xiangu (ST 43), Dadu (SP 2), Taibai (SP 3), 
   Zusanli (ST 36), etc. once every other day, 3 times a week for 4 weeks. The 
   changes of TCM symptom score, Toronto clinical assessment (TCSS) score, visual 
   analogue scale (VAS) score of pain and serum tumor necrosis factor α(TNF-α) level 
   were observed before and after treatment in the two groups, and the clinical 
   effects of the two groups were evaluated. RESULTS: Compared before treatment, the 
   TCM syndrome score and the TCSS score in the two groups were reduced after 
   treatment (P<0.05), and the TCM syndrome score after treatment in the observation 
   group was lower than that in the control group (P<0.05). After treatment, the VAS 
   in the observation group was reduced (P<0.05), and the VAS score of pain in the 
   observation group was lower than that in the control group (P<0.05). There was no 
   significant difference in the level of serum TNF-α within and between the two 
   groups (P>0.05). The total effective rate was 76.7% (23/30) in the observation 
   group, which was superior to 33.3% (10/30) in the control group (P<0.05). 
   CONCLUSION: Acupuncture at xing-spring point, shu-stream point and lower he-sea 
   point could effectively improve the neurological function and clinical symptoms 
   in patients with type-2 diabetic peripheral neuropathy.
C1 Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai200437, China.
   Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai200437, China.
   Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai200437, China.
   Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai200437, China.
   Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai200437, China.
   Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai200437, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD AUG 10
PY 2021
VL 41
IS 8
BP 866
EP 70
DI 10.13703/j.0255-2930.20200720-0007 
PG -796
WC Acupuncture Points; Acupuncture Therapy; Diabetes Mellitus, Type 2; complications; Diabetic Neuropathies; therapy; Humans; Rivers; Treatment Outcome
UT PubMed:34369696
PM 34369696
DA 2021-08-10
ER

PT J
AU Tola, YO
   Chow, KM
   Liang, W
AF Tola, Yetunde Oluwafunmilayo
   Chow, Ka Ming
   Liang, Wei
TI Effects of non-pharmacological interventions on preoperative anxiety and 
SO Journal of clinical nursing
LA English
DT Journal Article
DE anxiety; breast cancer surgery; non-medicine; non-pharmacological; pain
AB BACKGROUND: Poorly managed preoperative anxiety and pain were reported to slow 
   the postoperative recovery of breast cancer patients. Thus, proactive management 
   using non-pharmacological interventions becomes essential for decreasing opioid 
   or anxiolytics consumption, anxiety level, pain intensity, postoperative 
   complications and improving patients' haemodynamics and satisfaction with care. 
   PURPOSE: To identify, analyse and synthesise the effects of non-pharmacological 
   interventions on preoperative anxiety and acute postoperative pain in women 
   undergoing breast cancer surgery. METHOD: For this systematic review, 12 
   databases including Ovid Nursing, PsycInfo, British Nursing Index, CINAHL, 
   Cochrane Library were searched to identify relevant studies. A total of 6,012 
   articles were identified from the search, six RCTs and one quasi-experimental 
   study that met the inclusion criteria were included after eligibility screening. 
   Narrative synthesis was used to analyse data extracted from the included 
   articles. The review adhered to the PRISMA guideline. RESULTS: Twelve outcomes 
   were measured in the included studies, including preoperative anxiety, and acute 
   postoperative pain. Music, massage, aromatherapy and acupuncture were the 
   interventions delivered. Music had a small-to-large effect size and aromatherapy 
   had a small effect size on reducing preoperative anxiety. Also, music had a large 
   effect size whilst acupuncture had a medium effect size on minimising 
   postoperative pain in women undergoing breast cancer surgery. CONCLUSION: Music, 
   aromatherapy and acupuncture appeared to be effective for reducing preoperative 
   anxiety and postoperative pain in women undergoing breast cancer surgery. 
   However, the small number of studies available for each intervention prevents 
   conclusive statements about which the most effective method. IMPLICATION FOR 
   CLINICAL PRACTICE: A nursing care pathway that standardises the use of 
   non-pharmacological interventions for the management of both preoperative anxiety 
   and postoperative pain in breast cancer surgery patients should be developed.
C1 The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China.
   Institute of Nursing Research, Osogbo, Nigeria.
   The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China.
   The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China.
NR 0
TC 0
SN 1365-270
EI 
J9 J Clin Nurs
PD MAY 5
PY 2021
VL 30
IS 23-24
BP 3369
EP 3384
DI 10.1111/jocn.15827 
PG 15
WC Anxiety; prevention & control; Aromatherapy; Breast Neoplasms; surgery; Female; Humans; Music Therapy; Pain, Postoperative; therapy
UT PubMed:33942405
PM 33942405
DA 2021-05-05
ER

PT J
AU Abe, H
   Inoue, R
   Tsuchida, R
   Ando, M
   Saita, K
   Konishi, M
   Edamura, T
   Ogawa, A
   Matsuoka, Y
   Sumitani, M
AF Abe, Hiroaki
   Inoue, Reo
   Tsuchida, Rikuhei
   Ando, Masae
   Saita, Kosuke
   Konishi, Mitsuru
   Edamura, Tatsuma
   Ogawa, Asao
   Matsuoka, Yutaka
   Sumitani, Masahiko
TI Efficacy of treatments for pain and numbness in cancer survivors: a systematic 
SO Annals of palliative medicine
LA English
DT Journal Article
DE Meta-analysis; cancer survivors; numbness; pain; treatment
AB BACKGROUND: Pain and numbness in cancer survivors frequently have negative 
   impacts on quality of life (QoL). This meta-analysis aimed to identify the 
   current treatment options for pain and numbness in cancer survivors and to 
   evaluate their effects. METHODS: Cancer survivors were defined as patients 
   diagnosed with cancer who had completed active cancer treatment, whose conditions 
   were stable, and who had no evidence of recurrent or progressive disease. A 
   systematic search through the PubMed, MEDLINE, Embase, Cochrane Central Register 
   of Controlled Trials, Web of Science, PsycInfo, and CINAHL databases was 
   conducted, which targeted randomized controlled trials (RCTs) published until 
   April 2022 that evaluated any type of treatment for pain or numbness in cancer 
   survivors. A meta-analysis was conducted using the random-effects model to obtain 
   the effect sizes of 7 types of treatments: opioid therapy, nonopioid 
   pharmacotherapy, interventional therapy, acupuncture, education/cognitive 
   behavioral therapy (CBT), physical exercise, and alternative medicine. RESULTS: A 
   total of 36 studies involving 2,870 cancer survivors were included. Among them, 
   35 (n=2,813) were included in the meta-analysis for pain. The analysis suggested 
   that physical exercise [n=761; 13 studies; standardized mean difference (SMD) 
   -0.84; 95% confidence interval (CI): -1.14 to -0.55], acupuncture (n=409; 3 
   studies; SMD -0.80; 95% CI: -1.04 to -0.56), and alternative medicine (n=206; 6 
   studies; SMD -0.44; 95% CI: -0.71 to -0.16) could significantly reduce pain. 
   Nonopioid pharmacotherapy and education/CBT did not demonstrate significant 
   effects. No studies were identified that investigated the effects of opioid 
   therapy or interventional therapy on pain. Regarding numbness, 5 studies (n=566) 
   were included in the meta-analysis. Acupuncture (n=99; 2 studies) did not 
   demonstrate significant effects on numbness, and the effects of nonopioid 
   pharmacotherapy, education/CBT, and physical exercise could not be determined due 
   to the small number of included studies. No studies were identified that 
   investigated the effects of opioid therapy, interventional therapy, or 
   alternative medicine on numbness. CONCLUSIONS: This meta-analysis suggested that 
   physical exercise, acupuncture, and alternative medicine may reduce pain in 
   cancer survivors, with a very small to moderate amount of evidence. The effect of 
   treatments for numbness could not be determined due to the limited number of 
   included studies. Further studies are needed, particularly on widely used 
   pharmacotherapy.
C1 Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan.
   Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan.
   Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan.
   Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan.
   Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan.
   Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan.
   Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan.
   Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Tokyo, Japan.
   Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
   Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan.
NR 0
TC 0
SN 2224-583
EI 
J9 Ann Palliat Med
PD NOV 22
PY 2022
VL 11
IS 12
BP 3674
EP 3696
DI 10.21037/apm-22-420 
PG 22
WC Humans; Cancer Survivors; Analgesics, Opioid; Pain; Cognitive Behavioral Therapy; Quality of Life; Neoplasms; therapy
UT PubMed:36408559
PM 36408559
DA 2022-11-22
ER

PT J
AU Wang, MM
   Yu, XH
   Geng, W
   Cui, HF
   Wang, CC
   Han, J
   Yang, DH
AF Wang, Meng-Meng
   Yu, Xiao-Hua
   Geng, Wei
   Cui, Hua-Feng
   Wang, Chang-Chun
   Han, Jing
   Yang, Dian-Hui
TI [Effect of Manual Acupuncture Preconditioning on Behavior and Contents of Serum 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Behavioral score; Calcitonin gene-related peptide; Liver-soothing and mental-activity-regulating needling; Manual acupuncture; Migraine; Substance P; Tumor necrosis factor-α; interleukin-1 β
AB OBJECTIVE: To observe the effect of liver-soothing and mental-activity-regulating 
   (LSMAR) needling on behavior reactions and contents of serum calcitonin 
   gene-related peptide (CGRP), substance P (SP), interleukin-1 β (IL-1 β) and tumor 
   necrosis factor-α (TNF-α) in migraine rats, so as to explore its mechanism 
   underlying relief of migraine. METHODS: Thirty-two male Wistar rats were randomly 
   divided into control, model, LSMAR needling and conventional needling groups (n=8 
   rats in each). The migraine model was established by hypodermic injection of 
   glyceryl trinitrate (5 mg/kg) at the napex. Acupuncture preconditioning was 
   conducted once daily for 8 days before modeling. Acupuncture needles were 
   inserted into "Baihui" (GV 20), and bilateral "Fengchi" (GB 20), "Neiguan" (PC 6) 
   and "Taichong" (LR 3), manipulated for a while and retained for 30 min. The rats' 
   behavioral changes (times of head scratching, tail-biting, cage-crawling, and to- 
   and fro-movement in 30 min) were scored (one symptom = one point) before 
   modeling, after modeling, and after intervention. The concentrations of CGRP, SP, 
   IL-1 β, TNF-α in serum were assayed by enzyme-linked immunosorbent assay (ELISA). 
   RESULTS: After modeling, the behavioral scores were significantly increased in 
   the migraine model rats relevant to the control group (P<0.05). Whereas after the 
   treatment, the behavior scores were considerably decreased during 60-90 min and 
   120-150 min of the measuring period in both LSMAR and conventional needling 
   groups compared with the model group (P<0.05). The concentrations of CGRP, SP, 
   IL-1 β and TNF-α were significantly higher in the model group than in the control 
   group (P<0.05), and notably lower in both LSMAR and conventional needling groups 
   than in the model group (P<0.05). The therapeutic effect of LSMAR was markedly 
   superior to that of conventional needling in down-regulating the concentrations 
   of CGRP, SP, IL-1 β and TNF-α (P<0.05). CONCLUSION: Acupuncture preconditioning 
   can effectively relieve pain in migraine rats possibly by decreasing the 
   concentrations of CGRP, SP, IL-1 β and TNF-α in the peripheral blood, and the 
   therapeutic effect of LSMAR is evidently superior to that of conventional 
   needling.
C1 College of Acupuncture-moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
   College of Acupuncture-moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
   Department of Acupuncture and Moxibustion,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011.
   Department of Traditional Chinese Medicine, Shandong Maternal and Child Health Care Hospital, Jinan 250014.
   Department of Acupuncture and Moxibustion, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011.
   Department of Acupuncture and Moxibustion, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011.
   College of Acupuncture-moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
   Department of Acupuncture and Moxibustion,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011.
   College of Acupuncture-moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
   Shandong Provincial Key Laboratory ofTraditional Chinese Medicine, the Acupuncture Neurobio-logy Laboratory, Jinan250355.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD AUG 10
PY 2018
VL 43
IS 6
BP 375
EP 9
DI 10.13702/j.1000-0607.170415 
PG -366
WC Acupuncture Therapy; Animals; Calcitonin; Calcitonin Gene-Related Peptide; Interleukin-1beta; Male; Migraine Disorders; Rats; Rats, Sprague-Dawley; Rats, Wistar; Substance P; Tumor Necrosis Factor-alpha
UT PubMed:30091544
PM 30091544
DA 2018-08-10
ER

PT J
AU Li, M
   Zhang, J
   Liang, W
   Bai, W
   Lei, X
AF Li, Mengzhong
   Zhang, Jianguo
   Liang, Wenjie
   Bai, Wenjie
   Lei, Xiaoping
TI [Thermo-electroacupuncture at yaosanzhen for chronic lumbar muscle strain of cold 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE chronic lumbar muscle strain, cold dampness; randomized controlled trial (RCT); thermo-electroacupuncture comprehensive therapy device; visual analogue scale (VAS); yaosanzhen
AB OBJECTIVE: To compare the clinical efficacy between thermo-electroacupuncture at 
   yaosanzhen and oral celecoxib in the treatment of chronic lumbar muscle strain 
   with cold dampness. METHODS: A total of 80 patients with chronic lumbar muscle 
   strain of cold dampness were randomly divided into an observation group (40 
   cases, 1 case dropped out) and a control group (40 cases, 2 cases were excluded). 
   The observation group was treated with thermo-electroacupuncture at yaosanzhen 
   (bilateral Shenshu [BL23], Dachangshu [BL25], Weizhong [BL40]), disperse-dense 
   wave was selected, with a pulse cycle of 0.08 s, current intensity of 1-3 mA, 
   with needles heated to approximately 45 ℃, the duration was 25 min per session, 
   once a day. The control group was given oral celecoxib capsules, once daily, 200 
   mg each time. Six sessions as one course, with a 1-day interval between courses, 
   2 courses were required in both groups. The TCM syndrome score, visual analogue 
   scale (VAS) score, Oswestry disability index (ODI) score, and Japanese Orthopedic 
   Association (JOA) score before and after treatment in both groups were compared. 
   The serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), 
   thromboxane B2 (TXB2) and C-reactive protein (CRP) were detected using ELISA 
   method before and after treatment in both groups. The clinical efficacy was 
   evaluated in both groups after treatment. RESULTS: After treatment, the TCM 
   syndrome scores, VAS scores, ODI scores and serum levels of TNF-α, IL-6, TXB2, 
   CRP in both groups were reduced compared with those before treatment (P<0.01), 
   while the JOA scores were increased (P<0.01)；the TCM syndrome score, VAS score, 
   ODI score and serum levels of TNF-α, IL-6, TXB2, CRP in the observation group 
   were lower than those in the control group (P<0.01, P<0.05), and the JOA score 
   was higher than that in the control group (P<0.01). The total effective rate of 
   the observation group was 92.3% (36/39), which was superior to 78.9% (30/38) in 
   the control group (P<0.05). CONCLUSION: Thermo-electroacupuncture at yaosanzhen 
   can alleviate pain symptom in patients with chronic lumbar muscle strain of cold 
   dampness, regulate lumbar function, reduce the levels of inflammatory factors, 
   and the therapeutic effect is superior to oral celecoxib.
C1 Guangxi University of CM, Nanning 530001, China.
   Department of Acupuncture and Moxibustion, Ruikang Hospital Affiliated to Guangxi University of CM, Nanning 530011.
   Guangxi University of CM, Nanning 530001, China.
   Guangxi University of CM, Nanning 530001, China.
   Department of Acupuncture and Moxibustion, Ruikang Hospital Affiliated to Guangxi University of CM, Nanning 530011.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD OCT 11
PY 2025
VL 45
IS 10
BP 1421
EP 1426
DI 10.13703/j.0255-2930.20240924-k0001 
PG 5
WC Humans; Male; Female; Middle Aged; Adult; Electroacupuncture; Acupuncture Points; Sprains and Strains; therapy; Cold Temperature; Tumor Necrosis Factor-alpha; blood; Interleukin-6; blood; Aged; Treatment Outcome; Young Adult; C-Reactive Protein; metabolism; Chronic Disease; therapy; Lumbosacral Region; physiopathology
UT PubMed:41074517
PM 41074517
DA 2025-10-11
ER

PT J
AU Rodondi, PY
   Fernandez, A
   Dubois, J
   Ungarelli-McEvoy, C
   Bourqui, A
   Evéquoz, Y
   Luethi, E
   Zurron, N
   Berna, C
AF Rodondi, Pierre-Yves
   Fernandez, Aurore
   Dubois, Julie
   Ungarelli-McEvoy, Caitriona
   Bourqui, Angélique
   Evéquoz, Yves
   Luethi, Emmanuelle
   Zurron, Noemi
   Berna, Chantal
TI [Integrative medicine: scientific literature in 2021].
SO Revue medicale suisse
LA fre
DT Review
AB To illustrate the novelties in integrative and complementary medicine in 2021, 
   the authors present a selection of six articles. One of them is specifically 
   related to COVID-19. The other articles deal with themes that are always relevant 
   and where complementary approaches represent a real added value. Two articles 
   focus on low back pain, a common problem in primary care medicine. The others 
   examine acupuncture in the oncological context, the use of therapeutic 
   suggestions in an operative context, and Tai Chi. The authors thus provide an 
   overview of the range of possible complementary therapeutic approaches that are 
   increasingly supported by evidence, inviting them to be better integrated into 
   clinical practice.
C1 Institut de médecine de famille, Faculté des sciences et de médecine, Université de Fribourg, 1700 Fribourg.
   Centre de médecine intégrative et complémentaire et Centre d'antalgie, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.
   Institut de médecine de famille, Faculté des sciences et de médecine, Université de Fribourg, 1700 Fribourg.
   Centre de médecine intégrative et complémentaire et Centre d'antalgie, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.
   Institut de médecine de famille, Faculté des sciences et de médecine, Université de Fribourg, 1700 Fribourg.
   Institut de médecine de famille, Faculté des sciences et de médecine, Université de Fribourg, 1700 Fribourg.
   Institut de médecine de famille, Faculté des sciences et de médecine, Université de Fribourg, 1700 Fribourg.
   Centre de médecine intégrative et complémentaire et Centre d'antalgie, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.
   Centre de médecine intégrative et complémentaire et Centre d'antalgie, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.
NR 0
TC 0
SN 
EI 1660-937
J9 Rev Med Suisse
PD JAN 21
PY 2022
VL 18
IS 764-5
BP 40
EP 44
DI 10.53738/REVMED.2022.18.764-65.40 
PG 4
WC Acupuncture Therapy; COVID-19; Complementary Therapies; Humans; Integrative Medicine
UT PubMed:35048578
PM 35048578
DA 2022-01-21
ER

PT J
AU Li, D
   Chung, G
   Kim, SK
AF Li, Daxian
   Chung, Geehoon
   Kim, Sun Kwang
TI The Involvement of Central Noradrenergic Pathway in the Analgesic Effect of Bee 
SO Toxins
LA English
DT Journal Article
DE adrenergic receptor; bee venom acupuncture; chemotherapy-induced peripheral neuropathy; locus coeruleus; spinal wide dynamic range neuron; vincristine
AB Vincristine is a vinca alkaloid anti-mitotic drug with a broad spectrum of 
   effects on solid and hematologic cancers. The major dose-limiting factor of this 
   anti-cancer regimen is painful peripheral neuropathy. However, no gold-standard 
   analgesic option has been used clinically. In this study, we investigated the 
   effects and mechanism of bee venom acupuncture (BVA) to alleviate peripheral 
   neuropathic pain induced by repeated intraperitoneal infusions of vincristine (1 
   mg/kg/day, days 1-5 and 8-12) in rats. Subcutaneous injection with bee venom (BV, 
   1.0 mg/kg) at the ST36 acupoint ameliorated cold and mechanical hypersensitivity 
   (i.e., aberrant withdrawal responses in acetone drop and von Frey hair tests, 
   respectively). In vivo extracellular recording demonstrated that BVA inhibited 
   cutaneous cold (acetone) and mechanical (brush, press, and pinch) 
   stimuli-elicited abnormal hyperexcitation of the spinal wide dynamic range (WDR) 
   neurons in vincristine-treated rats. In addition, the microinjection of lidocaine 
   into the ipsilateral locus coeruleus or the antagonism of the spinal 
   α(2)-adrenergic receptors clearly reversed the effects of BVA on cold and 
   mechanical hypersensitivity, indicating a vital role of the descending 
   noradrenergic modulation in analgesia. These findings suggest that BVA could be a 
   potential therapeutic option for vincristine-induced peripheral neuropathy.
C1 Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
   Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
   Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
   Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 
   Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.
NR 0
TC 0
SN 2072-665
EI 
J9 Toxins (Basel)
PD DEC 10
PY 2020
VL 12
IS 12
BP 
EP 
DI 10.3390/toxins12120775 
PG 0
WC Acupuncture Points; Acupuncture Therapy; methods; Adrenergic Neurons; drug effects; Animals; Antineoplastic Agents, Phytogenic; toxicity; Bee Venoms; administration & dosage; Male; Microinjections; methods; Peripheral Nervous System Diseases; chemically induced; Rats; Rats, Sprague-Dawley; Vincristine; toxicity
UT PubMed:33291335
PM 33291335
DA 2020-12-10
ER

PT J
AU Kwekkeboom, KL
AF Kwekkeboom, Kristine L
TI Cancer Symptom Cluster Management.
SO Seminars in oncology nursing
LA English
DT Review
DE clinical practice; patient education; symptom cluster; symptom management; therapeutics
AB OBJECTIVES: To discuss the importance of cancer symptom clusters in clinical 
   practice, review evidence for symptom cluster interventions, and make 
   recommendations for symptom cluster identification, patient education, and 
   management in clinical practice. DATA SOURCES: Primary research and review 
   articles identified through CINAHL, PubMed, and PsycINFO databases. CONCLUSION: 
   Several studies have investigated interventions for multi-symptom management or 
   have evaluated the secondary effects of a single-symptom intervention on related 
   symptoms. To date, only five studies have tested an intervention designed to 
   manage a specific cancer symptom cluster. Those studies used nonpharmacologic 
   approaches (psycho-education, cognitive-behavioral strategies, and acupressure) 
   to address the pain, fatigue, and sleep disturbance symptom cluster, or the 
   respiratory distress symptom cluster with some initial evidence of success. 
   Further development and efficacy testing of symptom cluster interventions is 
   needed. IMPLICATIONS FOR NURSING PRACTICE: Clinical practice can be guided by 
   knowledge of individual and multi-symptom management, and clinical judgment 
   regarding possible etiologies of cancer symptom clusters. Clinicians should be 
   aware of co-occurring symptoms in their patients, educate and involve patients in 
   identifying symptom clusters and aggravating/alleviating factors, and coordinate 
   treatment recommendations using strategies that are likely to be beneficial 
   across symptoms.
NR 0
TC 0
SN 1878-344
EI 0749-208
J9 Semin Oncol Nurs
PD OCT 30
PY 2016
VL 32
IS 4
BP 373
EP 382
DI 10.1016/j.soncn.2016.08.004 
PG 9
WC Fatigue; Humans; Neoplasms; complications; Pain; Sleep Wake Disorders; Symptom Assessment; Syndrome
UT PubMed:27789073
PM 27789073
DA 2016-10-30
ER

PT J
AU Liu, J
   Wang, MM
   Yang, DH
   Cui, XX
AF Liu, Jie
   Wang, Meng-Meng
   Yang, Dian-Hui
   Cui, Xin-Xin
TI [Mechanisms of liver-soothing and mind-regulating acupuncture mediating opioid 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Interleukin-6; Migraine; Opioid receptors;Interleukin-1β; Tumor necrosis factor-α; “Shugan Tiaoshen” (liver-soothing and mind-regulating) acupuncture
AB OBJECTIVE: To observe the effect of "Shugan Tiaoshen"(liver-soothing and 
   mind-regulating) acupuncture on behavior reactions, opioid receptor expressions 
   in the anterior cingulate cortex tissue and inflammatory factors in the serum in 
   migraine rats, in order to explore its mechanism underlying improvement of 
   migraine. METHODS: In the first part of this study, forty male Wistar rats were 
   randomized into control, model, routine acupuncture and "Shugan Tiaoshen" 
   acupuncture groups (n=10/group), and in the second part, other 40 more male 
   Wistar rats were randomized into low, medium and high dosage of blocker of 
   μopioid receptor (OPRM）CTOP5 and PBS groups (n=10/group, for validating the 
   involvement of opioid receptor in the effect of "Shugan Tiaoshen"). The migraine 
   model was established by subcutaneous injection of glyceryl trinitrate. Routine 
   acupuncture was applied to "Baihui" (GV20) and bilateral"Fengchi" (GB20), and 
   "Shugan Tiaoshen" acupuncture applied to GV20, and bila-teral GB20, "Neiguan" 
   (PC6) and "Taichong" (LR3), with the needles retained for 30 min. Behavior 
   responses (head scratching, tail biting, cage climbing and number of going there 
   and back) were scaled. Serum IL-1β, IL-6 and TNF-α were detected by ELISA, and 
   the expression levels of opioid receptor μ, δ and κ (OPRM, OPRD, OPRK) mRNAs and 
   proteins in the anterior cingulate cortex were detected by fluorescence 
   quantitative PCR and Western blot separately. In the second part of this study, 
   CTOP solution (5μL at concentrations of 20μg/μL,10μg/μL and 5μg/μL) or PBS was 
   injected into the bilateral rostral portions of anterior cingulate cortex 30 min 
   before every "Shugan Tiaoshen" acupuncture intervention, followed by observing 
   the behavioral changes and assaying the contents of serum IL-1β, IL-6 and TNF-α. 
   RESULTS: After modeling, the behavioral score, serum IL-1β, IL-6 and TNF-α 
   contents were significantly increased in the model group relevant to the control 
   group (P<0.05), and the beha-vioral score had no significant difference among the 
   model and two acupuncture groups before intervention (P>0.05). Whereas the 
   expression levels of OPRM, OPRD and OPRK mRNAs and proteins had a slight increase 
   in the model group (P>0.05). After the intervention, the behavioral score, serum 
   IL-1β, IL-6 and TNF-α contents were significantly decreased and the expression 
   levels of OPRM, OPRD and OPRK mRNAs (2.150, 1.066 and 0.805 folds in the "Shugan 
   Tiaoshen" group) and proteins (2.273, 0.901 and 0.893 folds in the "Shugan 
   Tiaoshen" group) notably up-regulated in both "Shugan Tiaoshen" and routine 
   acupuncture groups relevant to the model group (P<0.01, P<0.05), showing that the 
   biggest up-regulation of mRNA expression was OPRM. Comparison between two 
   acupuncture groups showed that the behavioral score, and serum IL-1β, IL-6 and 
   TNF-α contents were significantly lower, and the expression levels of OPRM, OPRD 
   and OPRK mRNAs and proteins obviously higher in the "Shugan Tiaoshen" group than 
   those in the routine acupuncture group (P<0.01,P<0.05). Results of the second 
   part of this study showed that after injection of antagonist CTOP of OPRM, the 
   therapeutic effect of "Shugan Tiaoshen" acupuncture was weakened in the reduction 
   of behavioral score and serum IL-1β, IL-6 and TNF-α contents, being minimal, 
   moderate and maximum in the high, medium and low dose of antagonist relevant to 
   PBS in sequence (P<0.05, P<0.01). CONCLUSION: "Shugan Tiaoshen" acupuncture can 
   mitigate pain in migraine rats, which may be associated with its function in 
   up-regulating the expressions of opioid receptors (especially OPRM), and in 
   inhibiting inflammatory reaction in the anterior cingulate cortex.
C1 Department of Traditional Chinese Medicine, The Second Hospital of Shandong University, Jinan 250033, China.
   College of Acupuncture-moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355.
   College of Acupuncture-moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355
   Department of Acupuncture-moxibustion of TheAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan250014.
   Medical Teaching and Research Section of Shandong Medical College, Jinan 250024.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUN 29
PY 2022
VL 47
IS 6
BP 510
EP 6
DI 10.13702/j.1000-0607.20210691 
PG -504
WC Acupuncture Therapy; methods; Animals; Interleukin-6; Liver; Male; Migraine Disorders; genetics; Rats; Rats, Wistar; Receptors, Opioid; genetics; Tumor Necrosis Factor-alpha; genetics
UT PubMed:35764518
PM 35764518
DA 2022-06-29
ER

PT J
AU Feng, YH
   Kong, LY
   Sun, Y
   Gao, F
AF Feng, Yuan-Hui
   Kong, Ling-Yu
   Sun, Ying
   Gao, Fang
TI [Therapeutic effect of the combination of Tiaodu Lijin acupuncture therapy and 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Cervical spondylotic radiculopathy; Lijin reduction tuina manipulation; Tiaodu Lijin acupuncture therapy
AB OBJECTIVES: To explore the therapeutic effect of the combined measures of Tiaodu 
   Lijin acupuncture therapy (for regulating the governor vessel and tendons) and 
   Lijin reduction tuina manipulation (for regulating tendons and reduction) in 
   treatment of cervical spondylotic radiculopathy (CSR). METHODS: From August 2021 
   to December 2023, 160 CSR patients were selected and randomly divided into a 
   control group (80 cases) and a trial group (80 cases) using a random number table 
   method. In the control group, the conventional acupuncture and Lijin reduction 
   tuina manipulation were operated, and in the trial group, Tiaodu Lijin 
   acupuncture therapy and Lijin reduction tuina manipulation were combined. The 
   treatment was delivered once daily in each group, 5 interventions a week and 
   lasted for 4 weeks. Before and after treatment, the score of clinical assessment 
   scale of cervical spondylosis (CASCS), cervical dysfunction index (NDI) and the 
   score of visual analog scale (VAS) were compared in the two groups. Using ELISA, 
   the contents of interleukin (IL)-6, leukotriene D4 (LTD4), tumor necrosis factor 
   (TNF)-α and C-reactive protein (CRP) in the serum were detected. Transcranial 
   color Doppler ultrasound was used to detect the mean peak velocity (VM), 
   resistance index (RI) and pulsation index (PI) of vertebral-basilar artery at 
   systole. The effective rate was calculated in the two groups. RESULTS: Every 
   indicator after treatment was improved in comparison with that before treatment 
   in each group (P<0.05). After 4-week treatment, compared with the control group, 
   NDI and VAS scores were lower (P<0.05), and the serum contents of IL-6, LTD4, 
   TNF-α and CRP were reduced (P<0.05), RI and PI of vertebral-basilar artery were 
   lower (P<0.05), and CASCS score and VM were higher (P<0.05) in the trial group. 
   The overall effective rate in the trial group (95.00%, 76/80) was higher (P<0.05) 
   than that (81.25%, 65/80) in the control group. CONCLUSIONS: The combined 
   measures of Tiaodu Lijin acupuncture therapy and Lijin reduction tuina 
   manipulation obtain the satisfactory therapeutic effect on CSR, which alleviates 
   pain, reduces inflammatory indicators and improves vertebral basilar arterial 
   blood flow and cervical spine function.
C1 Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, Hebei Province, China.
   Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, Hebei Province, China. 506905766@qq.com.
   Tangshan Fengnan District Hospital of Traditional Chinese Medicine, Tangshan 063300, Hebei Province.
   Tangshan Fengnan District Hospital of Traditional Chinese Medicine, Tangshan 063300, Hebei Province.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD SEP 18
PY 2025
VL 50
IS 9
BP 1088
EP 1094
DI 10.13702/j.1000-0607.20250309 
PG 6
WC Humans; Acupuncture Therapy; Male; Middle Aged; Female; Spondylosis; therapy; Radiculopathy; therapy; Adult; Acupuncture Points; Aged; Tumor Necrosis Factor-alpha; blood; Interleukin-6; blood; Treatment Outcome; C-Reactive Protein; metabolism; Combined Modality Therapy
UT PubMed:40962733
PM 40962733
DA 2025-09-18
ER

PT J
AU Jiang, TX
   Wang, BG
   Yang, QQ
   Liu, W
   Ma, SL
   Li, F
   Yang, J
AF Jiang, Tian-Xin
   Wang, Bao-Guo
   Yang, Qi-Qi
   Liu, Wen
   Ma, Shou-Liang
   Li, Fei
   Yang, Jun
TI Observation of clinical efficacy of acupuncture combined with bloodletting 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acupuncture; Bloodletting; COVID-19 infection; Qingwen Xiere decoction
AB OBJECTIVES: To evaluate the clinical efficacy and safety of acupuncture combined 
   with bloodletting therapy and Qingwen Xiere decoction in mild to moderate 
   COVID-19 patients. METHODS: A total of 100 mild to moderate COVID-19 patients 
   collected from December 2022 to February 2023 were randomly divided into control 
   and observation groups, with 50 patients in each group. Patients in the control 
   group received oral Qingwen Xiere decoction for 6 days. The observation group 
   received acupuncture combined with bloodletting therapy in addition to oral 
   Qingwen Xiere decoction, with the acupuncture (at Kongzui ［LU6］, Hegu ［LI4］, 
   Quchi ［LI11］, Feishu ［BL13］, Zhongwan ［CV12］, Qihai ［CV6］, Yinlingquan ［SP9］) 
   administered 30 min each day for 6 days, and bloodletting (at Shaoshang ［LU11］, 
   Shangyang ［LI1］, Dazhui ［GV14］) administered every other day for 3 times. 
   Traditional Chinese medicine syndrome scores and pulmonary CT scores were 
   recorded before and after treatment. Serum contents of C-reactive protein (CRP), 
   interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were measured using 
   ELISA. Anxiety and depression degree were assessed using the Hamilton Depression 
   Scale (HAMD) and Hamilton Anxiety Scale (HAMA). Safety of the treatments was 
   evaluated in both groups. RESULTS: Compared with before treatment, after 
   treatment, the control group showed improvement in fever, dry cough, sore throat, 
   and total traditional Chinese medicine syndrome scores (P<0.01), but no 
   significant improvement in muscle pain or fatigue；the observation group showed 
   significant improvement in total traditional Chinese medicine syndrome and 
   individual symptoms scores (P<0.01)；both groups demonstrated reductions in 
   pulmonary CT scores, HAMA score, HAMD score and serum contents of CRP and IL-6 
   (P<0.01)；serum TNF-α content significantly decreased in the observation group 
   (P<0.01). All outcome measures were superior in the observation group to the 
   control group (P<0.01, P<0.05). No adverse reactions were reported in either 
   group. CONCLUSIONS: Acupuncture combined with bloodletting therapy and oral 
   Qingwen Xiere decoction effectively improves clinical symptoms, alleviates 
   pulmonary inflammatory injury, reduces inflammatory cytokine contents, and 
   mitigates anxiety and depression in mild to moderate COVID-19 patients, and 
   without adverse effects.
C1 The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, China.
   The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, China.
   Anhui University of Chinese Medicine, Hefei 230000.
   The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province.
   The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031.
   The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, China. 316029622@qq.com.
   Anhui University of Chinese Medicine, Hefei 230000.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD SEP 25
PY 2024
VL 49
IS 8
BP 845
EP 850
DI 10.13702/j.1000-0607.20230316 
PG 5
WC Humans; COVID-19; therapy; Male; Female; Drugs, Chinese Herbal; therapeutic use; Acupuncture Therapy; Middle Aged; Bloodletting; Adult; Treatment Outcome; Combined Modality Therapy; SARS-CoV-2; Aged; Interleukin-6; blood; C-Reactive Protein; metabolism; Acupuncture Points; Tumor Necrosis Factor-alpha; blood
UT PubMed:39318314
PM 39318314
DA 2024-09-25
ER

PT J
AU Wu, J
   Tang, Q
   Tan, X
AF Wu, Jia
   Tang, Qiong
   Tan, Xiaofei
TI Sodium hyaluronate and acupotomy bone decompression alleviates inflammatory 
SO Inflammopharmacology
LA English
DT Journal Article
DE Bone marrow edema; Inflammation; Knee osteoarthritis; MRI; Needle-knife bone decompression surgery; Sodium hyaluronate
AB OBJECTIVE: Knee osteoarthritis (KOA), predominantly affecting middle-aged and 
   elderly populations, induces localized joint pain and functional impairment. It 
   was to evaluate the effectiveness of acupotomy bone decompression (ABD) combined 
   with sodium hyaluronate (SH) intra-articular injection on inflammatory responses 
   in treating KOA. METHODS: Clinical data from 128 patients with KOA were 
   retrospectively collected, categorized into SH group (n = 55) and ABD + SH group 
   (n = 73). Pain was assessed using the visual analogue scale (VAS), knee joint 
   function was evaluated, and knee joint balance and gait parameters were measured. 
   The status of articular cartilage and bone marrow edema was evaluated using 
   quantitative magnetic resonance imaging (MRI). Interleukin (IL)-6, IL-1β, tumor 
   necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-3, MMP-9, and 
   hypersensitive C-reactive protein (hs-CRP) were detected. RESULTS: ABD + SH group 
   showed drastic reductions in VAS scores, decreased indices of different axial 
   balances, and increased stride length and walking speed versus the SH group 
   (P < 0.05). Quantitative MRI examination revealed that relative to the SH group, 
   ABD + SH group exhibited increased thickness of articular cartilage and reduced 
   area of bone marrow edema post-treatment (P < 0.05). Post-treatment levels of 
   hs-CRP, IL-6, IL-1β, TNF-α, MMP-3, and MMP-9 were markedly lower in the ABD + SH 
   group versus SH group (P < 0.05). Moreover, the clinical effective rate in the 
   ABD + SH group was drastically superior to the SH group (95.9% vs. 78.2%, 
   P < 0.05). CONCLUSION: Combining ABD with SH treatment for KOA effectively 
   alleviates patient pain and inflammatory responses.
C1 Department of Rheumatoid Osteoarthrosis, Sichuan Orthopedics Hospital, Sichuan Province, Chengdu, 610000, China.
   Department of Radiology, The People's Hospital of Chongqing Liang Jiang New Area, Chongqing, 401120, China.
   Department of Orthopedic, Yunyang County Traditional Chinese Medicine Hospital, Chongqing, 404500, China. 796458@finmail.com.
NR 0
TC 0
SN 1568-560
EI 
J9 Inflammopharmacology
PD FEB 20
PY 2025
VL 33
IS 4
BP 1997
EP 2005
DI 10.1007/s10787-025-01667-4 
PG 8
WC Humans; Osteoarthritis, Knee; therapy; Male; Female; Hyaluronic Acid; administration & dosage; Middle Aged; Aged; Retrospective Studies; Inflammation; drug therapy; Decompression, Surgical; methods; Acupuncture Therapy; methods; Magnetic Resonance Imaging; methods; Knee Joint; Injections, Intra-Articular; Treatment Outcome; Pain Measurement; methods
UT PubMed:39976668
PM 39976668
DA 2025-02-20
ER

PT J
AU Almeida, KAM
   Rocha, AP
   Carvas, N
   Pinto, ACPN
AF Almeida, Kleicyane Aguiar Meireles
   Rocha, Aline Pereira
   Carvas, Nelson
   Pinto, Ana Carolina Pereira Nunes
TI Rehabilitation Interventions for Shoulder Dysfunction in Patients With Head and 
SO Physical therapy
LA English
DT Journal Article
DE Cancer; Head and neck neoplasms; Physical therapy; Rehabilitation; Systematic review
AB OBJECTIVE: Shoulder pain and dysfunction are highly prevalent after neck 
   dissection in the treatment of head and neck cancer (HNC). They can lead to 
   muscle weakness, limited range of motion, and shoulder tilt and pain, which can 
   reduce patient functioning. The purpose of this study was to evaluate the 
   effectiveness of rehabilitation interventions for shoulder dysfunction in 
   patients with surgically treated HNC. METHODS: A search of principal databases 
   (MEDLINE, Embase, CENTRAL, LILACS, IBECS, PEDro, and SciELO) was conducted, in 
   addition to hand searches and a search of gray literature, for all randomized 
   clinical trials (RCTs) published before February 2020. Two authors independently 
   selected all relevant studies. The 7 RCTs fulfilling all inclusion and exclusion 
   criteria were assessed for risk of bias and certainty of evidence using the 
   Cochrane Collaboration risk-of-bias tool and the Grading of Recommendations 
   Assessment, Development and Evaluation (GRADE) tool, respectively. RESULTS: 
   Moderate-certainty evidence suggests that progressive resistance training is 
   better than conventional treatment for improving pain and dysfunction in patients 
   with HNC (pooled data from 214 participants; mean difference = -5.92; 95% 
   CI = -11.38 to -0.45). Low-certainty evidence (data from 2 RCTs with 106 
   participants that could not be combined) suggests that acupuncture seems to be 
   more effective than conventional treatment. CONCLUSIONS: Progressive resistance 
   training is effective for improving shoulder pain and dysfunction in patients 
   with HNC. Further high-quality RCTs are needed to examine the effectiveness of 
   acupuncture for improving shoulder pain and dysfunction in these patients. Future 
   studies with longer follow-up times are needed to clarify the effects of early 
   postoperative intervention. IMPACT: Clinicians can have confidence that 
   progressive resistance training in patients with surgically treated HNC is 
   effective. LAY SUMMARY: These study results show that people with head and neck 
   cancer can benefit from gradually increased resistance training to reduce 
   shoulder pain and improve function. This study will help researchers design 
   clinical trials to determine whether treatments such as acupuncture and early 
   physical therapy also could be effective in treating this population.
C1 Biological and Health Sciences Department, Universidade Federal do Amapá, Rod. Juscelino Kubitschek, km-02 Jardim Marco Zero, Macapá, AP, CEP 68.903-419 Brazil.
   Discipline of Emergency and Evidence-Based Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.
   Department of Physical Education, Instituto de Assistência Médica ao Servidor Público Estadual, São Paulo, São Paulo, Brazil.
   Fulbright Alumna at University of Pittsburgh, Pittsburgh, Pennsylvania, USA
   Biological and Health Sciences Department, Universidade Federal do Amapá.
NR 0
TC 0
SN 1538-672
EI 
J9 Phys Ther
PD AUG 5
PY 2020
VL 100
IS 11
BP 1997
EP 2008
DI 10.1093/ptj/pzaa147 
PG 11
WC Head and Neck Neoplasms; complications; Humans; Muscle Weakness; etiology; Physical Therapy Modalities; Randomized Controlled Trials as Topic; Resistance Training; Shoulder Pain; etiology
UT PubMed:32750136
PM 32750136
DA 2020-08-05
ER

PT J
AU Guo, YJ
   Su, SY
   Su, H
   Yang, P
   Li, J
   Xie, CY
AF Guo, Yan-Jun
   Su, Sheng-Yong
   Su, Hong
   Yang, Pu
   Li, Jing
   Xie, Cai-Yun
TI [Mechanism of analgesic effect of electroacupuncture on rats with cervical 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Astrocyte; Central sensitization; Cervical spondylosis radiculopathy; Chemokine; Electroacupuncture; High mobility group protein B1/Toll-like receptor 4/myeloid differentiation ; Inflammatory cytokine
AB OBJECTIVES: To observe effects of electroacupuncture (EA) on the activation of 
   astrocytes and high mobility group protein B1(HMGB1)/Toll-like receptor 4 
   (TLR4)/myeloid differentiation factor 88 (MyD88) signaling pathway, as well as 
   related cytokines in rats with cervical spondylosis radiculopathy(CSR), so as to 
   explore the analgesic mechanism of EA in treating CSR. METHODS: Twenty-four male 
   SD rats were randomly divided into blank, sham surgery, model, and EA groups, 
   with 6 rats in each group. CSR rat model was established by using cervical spinal 
   cord canal puncture method. On the 7(th) day after successful modeling, EA was 
   applied to rats in the EA group at bilateral "Hegu"(LI4) and "Taichong"(LR3) for 
   20 minutes(1.5 Hz, 1 mA), once daily for 7 consecutive days. Before and after 
   intervention, gait impairment scores and mechanical pain thresholds were 
   assessed. HE staining was used to observe pathological changes in spinal cord 
   tissue. Western blot was used to detect the expression of HMGB1, TLR4, MyD88, and 
   glial fibrillary acidic protein (GFAP) in the spinal cord. ELISA was used to 
   measure the contents of CXC chemokine ligand 1 (CXCL1), chemokine ligand 2 
   (CCL2), tumor necrosis factor (TNF)-α, and interleukin (IL)-1β in spinal cord. 
   Immunofluorescence staining was used to observe GFAP protein positive expression 
   in spinal cord tissue. RESULTS: There was no significant difference of all 
   indexes between the blank group and the sham surgery group. Compared with the 
   sham surgery group, mechanical pain threshold of rats in the model group was 
   decreased(P<0.01), while gait impairment score, the contents of CXCL1, CCL2, 
   TNF-α, IL-1β, protein expressions of HMGB1, TLR4, MyD88 and GFAP, and positive 
   expression of GFAP in spinal cord tissue were increased (P<0.01)；HE staining 
   indicated severe overall morphological damage in the spinal cord of rats in the 
   model group, with significant shrinkage of gray matter neurons, reduced number of 
   Nissl bodies, and increased inflammatory cell infiltration. Compared with the 
   model group, mechanical pain threshold in the EA group was increased (P<0.01), 
   while gait impairment score, the contents of CXCL1, CCL2, TNF-α, IL-1β, protein 
   expressions of HMGB1, TLR4, MyD88 and GFAP, and positive expression of GFAP in 
   spinal cord were reduced (P<0.01)；HE staining showed more intact neuronal cell 
   bodies, increased number of Nissl bodies, and reduced shrinkage of gray matter 
   neurons, inflammatory cell infiltration, and microvascular dilation in the spinal 
   cord of rats in the EA group. CONCLUSIONS: EA can effectively alleviate pain in 
   CSR rats, which is possibly by inhibiting astrocyte activation, HMGB1/TLR4/MyD88 
   signaling pathway, and reducing the release of related inflammatory cytokines, 
   thus alleviating central sensitization in spinal segments.
C1 Guangxi University of Chinese Medicine, Nanning 530001, China.
   Guangxi Key Laboratory of Molecular Biology of Traditional Chinese Medicine, Nanning 530023. 1037097555@qq.com.
   The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 
   Guangxi University of Chinese Medicine, Nanning 530001, China.
   Guangxi University of Chinese Medicine, Nanning 530001, China.
   Guangxi University of Chinese Medicine, Nanning 530001, China.
   Guangxi University of Chinese Medicine, Nanning 530001, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD OCT 15
PY 2024
VL 49
IS 9
BP 909
EP 916
DI 10.13702/j.1000-0607.20230789 
PG 7
WC Animals; Rats; Male; Rats, Sprague-Dawley; Electroacupuncture; Toll-Like Receptor 4; metabolism; Myeloid Differentiation Factor 88; metabolism; HMGB1 Protein; metabolism; Signal Transduction; Radiculopathy; therapy; Humans; Astrocytes; metabolism; Spondylosis; therapy; Acupuncture Points
UT PubMed:39401827
PM 39401827
DA 2024-10-15
ER

PT J
AU DU, XZ
   Liu, LM
   Liu, C
   Jing, WY
   Yuan, B
   Zhang, XH
   Zhang, FF
   Li, XJ
   Liu, Q
   Wang, HD
AF DU, Xiao-Zheng
   Liu, Li-Mei
   Liu, Cui
   Jing, Wei-Yao
   Yuan, Bo
   Zhang, Xing-Hua
   Zhang, Feng-Fan
   Li, Xiang-Jun
   Liu, Qiang
   Wang, Hai-Dong
TI [Effect of heat-reinforcing needling on expression profile of LncRNAs in synovial 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Heat-reinforcing needling; Long noncoding RNA; Rheumatoid arthritis
AB OBJECTIVES: To observe the effect of heat-reinforcing needling on the expression 
   profile of long non-coding RNA (LncRNA) in the synovial tissue of rabbits with 
   cold-syndrome type rheumatoid arthritis (RA), so as to explore its mechanisms 
   underlying improvement of RA. METHODS: A total of 18 New Zealand rabbits were 
   randomly divided into normal, model and heat-reinforcing needling (acupuncture) 
   groups, with 6 rabbits in each group. The RA model was established by injection 
   of mixed solution (emulsifier) of ovalbumin powder(80 mg) + NaCl (20 mL) 
   +Freund's complete adjuvant (20 mL), combined with cold compress (ice cube 
   +crystal calcium chloride) of the knee-joint. In addition, rabbits of the normal 
   and model groups received regular grasping and fixation in the same way as those 
   of the acupuncture group. For rabbits of the acupuncture group, the 
   heat-reinforcing needling stimulation was applied to bilateral "Zusanli" (ST36) 
   for about 1 min, followed by retaining the needle for 30 min, once a day, for a 
   total of 7 d. The rabbits' general condition was observed, and the knee joint 
   circumference and pain threshold after intervention were measured. The knee-joint 
   cavity effusion, synovial thickness, and internal blood flow signals were 
   observed using a color Doppler ultrasound apparatus. Histopathological changes of 
   synovium were observed using H.E. staining. The contents of serum tumor necrosis 
   factor α (TNF-α), interleukin (IL)-1β and IL-6 were detected using enzyme linked 
   immunosorbent assay (ELISA), and the differential LncRNAs and biological 
   functions in the synovial tissues were detected and analyzed using 
   high-throughput sequencing technology. The expression levels of 5 significantly 
   differentially expressed LncRNAs were verified using qPCR. RESULTS: Compared with 
   the normal group, the model group of rabbits showed a significant increase in the 
   knee joint circumference (P<0.05) and the content of serum TNF-α, IL-1β, IL-6 
   (P<0.05), and a significant decrease in the pain threshold (P<0.05), and diffuse 
   synovial hyperplasia of the synovial membrane, joint effusion and abnormal blood 
   flow signals, proliferated and thickened synovial lining, with visible capillary 
   formation beneath the lining and a large number of inflammatory cell clustering. 
   In comparison with the model group, the knee joint circumference, and the serum 
   contents of TNF-α, IL-1β and IL-6 were obviously decreased (P<0.05), while the 
   pain threshold was notably increased (P<0.05), and H.E. staining showed a 
   reduction in the hyperplasia of synovial lining, with a milder inflammatory cell 
   infiltration. High-throughput sequencing and bioinformatics analysis displayed 
   that a total of 142 LncRNAs were found to have opposite expression trends between 
   the acupuncture group and the model group, of which 83 LncRNAs were up-regulated 
   in the model group vs the normal group and down-regulated in the acupuncture 
   group vs the model group, mainly involving the core functional clusters of cell 
   cycle, mitogen-activated protein kinase (MAPK) signaling and cell senescence, and 
   59 LncRNAs were down-regulated in the model group vs the normal group, and 
   up-regulated in the acupuncture group vs the model group, mainly involving the 
   metabolic pathway, peroxisome proliferator-activated receptor (PPAR) signaling 
   and AMP-dependent protein kinase (AMPK) signaling. The results of qPCR showed 
   that compared with the normal group, the expression levels of MSTRG.15448.1 and 
   MSTRG.17571.1 in the synovial tissue of knee joint were significantly decreased 
   (P<0.05), and those of MSTRG.5134.1, MSTRG.13294.1 and MSTRG.15972.1 were 
   significantly increased (P<0.05) in the model group. Compared with the model 
   group, the expression levels of MSTRG.15448.1 and MSTRG.17571.1 were 
   significantly increased (P<0.05), and those of MSTRG.5134.1, MSTRG.13294.1 and 
   MSTRG.15972.1 were significantly decreased (P<0.05) in the acupuncture group. 
   CONCLUSIONS: The heat-reinforcing needling can regulate the expression profile of 
   LncRNAs in the RA synovial tissue, which may be one of the mechanisms underlying 
   inhibition of synovial inflammatory response and improvement of symptoms.
C1 College of Acupuncture-moxibusition and Massage, Gansu University of Chinese Medicine, Lanzhou 730000, China.
   Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000.
   College of Acupuncture-moxibusition and Massage, Gansu University of Chinese Medicine, Lanzhou 730000, China.
   College of Acupuncture-moxibusition and Massage, Gansu University of Chinese Medicine, Lanzhou 730000, China.
   Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000.
   Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050.
   Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050.
   Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050.
   College of Acupuncture-moxibusition and Massage, Gansu University of Chinese Medicine, Lanzhou 730000, China.
   Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050. whaidong5859@163.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD FEB 18
PY 2025
VL 50
IS 1
BP 65
EP 75
DI 10.13702/j.1000-0607.20240026 
PG 10
WC Animals; Rabbits; RNA, Long Noncoding; genetics; Arthritis, Rheumatoid; genetics; Acupuncture Therapy; instrumentation; Synovial Membrane; metabolism; Humans; Male; Acupuncture Points; Female; Tumor Necrosis Factor-alpha; genetics; Interleukin-6; genetics
UT PubMed:39961760
PM 39961760
DA 2025-02-18
ER

PT J
AU Pan, SL
   Zheng, SL
   Zhou, XH
   Wang, QL
AF Pan, Sheng-Lian
   Zheng, Shi-Li
   Zhou, Xia-Hui
   Wang, Qing-Lai
TI [Acupuncture combined with Jingtong granule for nerve-root type cervical 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE Jingtong granule; acupuncture; hemorheology; interleukin-1 beta (IL-1β); interleukin-6 (IL-6); nerve-root type cervical spondylosis; tumor necrosis factor-alpha (TNF-α)
AB OBJECTIVE: To explore the clinical efficacy of acupuncture combined with Jingtong 
   granule for nerve-root type cervical spondylosis and its effects on serum 
   interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta 
   (IL-1β) and hemorheological indexes. METHODS: A total of 114 patients with 
   nerve-root type cervical spondylosis were randomly divided into an observation 
   group and a control group, 57 cases in each group. The patients in both groups 
   were treated with traction. The patients in the control group were treated with 
   oral administration of Jingtong granule, 4 g each time, 3 times a day, while 
   based on the treatment of control group, the patients in the observation group 
   were treated with acupuncture at Dazhui (GV 14), Tianzhu (BL 10), Houxi (SI 3), 
   cervical Jiaji (EX-B 2), Quchi (LI 11), Hegu (LI 4) and Waiguan (TE 5), once a 
   day. Both groups were treated for 4 weeks. The simplified McGill pain 
   questionnaire (MPQ), neck disability index (NDI), numbness score, levels of IL-6, 
   TNF-α, IL-1β in serum and hemorheological indexes were observed before and after 
   treatment, and the clinical efficacy was compared between the two groups. 
   RESULTS: The total effective rate was 91.2% (52/57) in the observation group, 
   which was higher than 71.9% (41/57) in the control group (P<0.05). Compared 
   before treatment, the scores of MPQ, NDI and numbness in the two groups were 
   reduced after treatment (P<0.05). After treatment, the scores of MPQ, NDI and 
   numbness in the observation group were lower than those in the control group 
   (P<0.05). After treatment, the serum levels of IL-6, TNF-α and IL-1β in the two 
   groups were reduced (P<0.05), and those in the observation group were lower than 
   the control group (P<0.05). After treatment, the plasma viscosity, fibrinogen, 
   low shear rate of whole blood viscosity and high shear rate of whole blood 
   viscosity in the two groups were lower than before treatment (P<0.05), and those 
   in the observation group were lower than the control group (P<0.05). CONCLUSION: 
   Acupuncture combined with Jingtong granule have significant clinical efficacy for 
   nerve-root type cervical spondylosis, which could reduce the serum levels of 
   IL-6, TNF-α and IL-1β and improve hemorheology.
C1 Department of Acupuncture and Moxibustion, Wenzhou Hospital of TCM, Wenzhou 325000, Zhejiang Province, China.
   Department of Acupuncture and Moxibustion, Wenzhou Hospital of TCM, Wenzhou 325000, Zhejiang Province, China.
   Department of Acupuncture and Moxibustion, Wenzhou Hospital of TCM, Wenzhou 325000, Zhejiang Province, China.
   Department of Acupuncture and Moxibustion, Wenzhou Hospital of TCM, Wenzhou 325000, Zhejiang Province, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD DEC 11
PY 2019
VL 39
IS 12
BP 1274
EP 8
DI 10.13703/j.0255-2930.2019.12.005 
PG -1266
WC Acupuncture Therapy; Humans; Interleukin-1beta; Interleukin-6; Spondylosis; therapy; Tumor Necrosis Factor-alpha
UT PubMed:31820601
PM 31820601
DA 2019-12-11
ER

PT J
AU Chen, Q
   Feng, J
   Liu, Z
   An, D
   Li, Y
   Zhou, S
   Weng, Z
AF Chen, Qi
   Feng, Jiaming
   Liu, Zhidan
   An, Dongyang
   Li, Yadan
   Zhou, Shaohu
   Weng, Zhiwei
TI Research trends of prostatitis over past 20 years: A bibliometric analysis.
SO Andrologia
LA English
DT Journal Article
DE VOSviewer; bibliographic item co-occurrence matrix builder; bibliometric analysis; prostatitis; research trends
AB In the past two decades, thousands of documents in the field of prostatitis have 
   been published. This bibliometric analysis aimed to assess the characteristics, 
   hotspots and frontiers trend of global scientific output on prostatitis. With the 
   trend of moderate growth, altogether 2,423 papers were reviewed. The leading role 
   of the United States in global prostatitis research was obvious, while China had 
   developed rapidly in recent years. Queen's University and JOURNAL OF UROLOGY were 
   the most prolific affiliation and journal respectively. Nickel, J. C made the 
   greatest contribution to the field of prostatitis. Five hotspots have been 
   confirmed: (a) male infertility associated with prostatitis and the molecular 
   mechanisms; (b) diagnosis and treatment of prostatitis; (c) inflammation, pain 
   and bladder irritation symptoms; (d) relationship between chronic 
   prostatitis/chronic pelvic pain syndrome, benign prostatic hyperplasia and 
   prostate cancer; (e) epidemiology, complications of prostatitis and improvement 
   of acupuncture. This bibliometric analysis reveals that the international 
   cooperation was becoming more and more close. Hotspot analysis shows that the 
   molecular mechanism of prostatitis will be a hotspot in the future, mainly 
   focussing on inflammatory immunity and oxidative stress.
C1 The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
   Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 
   The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
   Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, 
   The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
   The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
   The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
   The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
   The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 
   The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
   The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 
NR 0
TC 0
SN 1439-027
EI 
J9 Andrologia
PD AUG 9
PY 2021
VL 53
IS 10
BP e14206
EP e14206
DI 10.1111/and.14206 
PG 1
WC Acupuncture Therapy; Bibliometrics; China; epidemiology; Humans; Male; Prostatic Hyperplasia; epidemiology; Prostatitis; epidemiology; United States
UT PubMed:34365673
PM 34365673
DA 2021-08-09
ER

PT J
AU Sun, L
   Wei, X
   Wang, K
   Ye, Z
   Zhou, J
AF Sun, Linxi
   Wei, Xuqiang
   Wang, Ke
   Ye, Zi
   Zhou, Jia
TI Combined anesthesia of acupuncture-pharmacotherapy in pulmonary resection 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA English
DT Journal Article
DE Meta-analysis; combined anesthesia of acupuncture-pharmacotherapy; pulmonary resection surgery; systematic review
AB OBJECTIVES: To evaluate the clinical value and safety of combined anesthesia of 
   acupuncture-pharmacotherapy in pulmonary resection surgery. METHODS: The 
   randomized controlled trials (RCTs) related to combined anesthesia of 
   acupuncture-pharmacotherapy in pulmonary resection surgery were searched in 
   PubMed, EMbase, Cochrane Library, Web of Science, SinoMed, CNKI, VIP database, 
   Wanfang database, ClinicalTrials.gov, and the Chinese Clinical Trial Registry 
   (http://www.chictr.org.cn/) from the inception of each database up to July 12, 
   2022. The methodological quality of the included studies was assessed using the 
   Cochrane risk of bias tool, and Meta-analysis was conducted using RevMan5.4. 
   RESULTS: A total of 33 RCTs were included, involving 2 526 participants. The 
   Meta-analysis results showed that compared to conventional anesthesia, the 
   patients receiving combined anesthesia of acupuncture-pharmacotherapy had more 
   stable vital signs during surgery, reduced intraoperative fentanyl usage 
   [SMD=-3.73, 95%CI(-5.28, -2.18), Z=4.72, P<0.000 01], decreased postoperative 
   sufentanil consumption [MD=-20.85, 95%CI(-24.84, -16.86), Z=10.24, P<0.000 01], 
   reduced total/effective presses of the postoperative patient-controlled analgesia 
   pump [MD=-5.70, 95% CI(-9.04, -2.36), Z=3.35, P=0.000 8], lowered postoperative 
   pain visual analogue scale (VAS) [MD=-1.63, 95%CI(-2.02, -1.23), Z=7.97, P<0.000 
   01], shorter length of postoperative hospital stay [MD=-1.14, 95%CI(-1.85, 
   -0.43), Z=3.15, P=0.002], and higher levels of CD 4+ T lymphocytes, CD 8+ T 
   lymphocytes, natural killer (NK) cell activity, and superoxide dismutase (SOD). 
   Additionally, tumor necrosis factor-alpha (TNF-α), adrenaline and cortisol levels 
   were decreased (P<0.05). No adverse events related to acupuncture or electrical 
   stimulation were reported, and the incidence of postoperative complications was 
   lower than that of conventional anesthesia [RR=0.47, 95%CI(0.36, 0.62), Z=5.36, 
   P<0.000 01]. CONCLUSIONS: The combined anesthesia of acupuncture-pharmacotherapy 
   in pulmonary resection surgery could improve anesthesia and analgesia 
   effectiveness, reduce anesthesia drug usage, regulate immune responses, suppress 
   stress reactions, and the safety is satisfactory. However, there is substantial 
   heterogeneity among the included studies, and outcome measures vary widely. 
   Further large-sample, high-quality, internationally standardized clinical trials 
   are needed to clarify its clinical value and safety, providing reliable evidence 
   for clinical practice.
C1 Clinical Research Office of Acupuncture Anesthesia, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM,Shanghai 200437, China. sunlxhb@163.com.
   Graduate School of Shanghai University of TCM, Shanghai 201203. sunlxhb@163.com.
   Clinical Research Office of Acupuncture Anesthesia, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM,Shanghai 200437, China.
   Clinical Research Office of Acupuncture Anesthesia, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM,Shanghai 200437, China.
   Clinical Research Office of Acupuncture Anesthesia, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM,Shanghai 200437, China.
   Clinical Research Office of Acupuncture Anesthesia, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM,Shanghai 200437, China. pdzhoujia@163.com.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JAN 9
PY 2024
VL 44
IS 1
BP 109
EP 122
DI 10.13703/j.0255-2930.20221008-0005 
PG 13
WC Humans; Anesthesia; Acupuncture Therapy; Postoperative Complications; Pain Management; Analgesia, Patient-Controlled
UT PubMed:38191169
PM 38191169
DA 2024-01-09
ER

PT J
AU Chen, K
   Li, C
AF Chen, Kaijun
   Li, Caili
TI [Acupuncture combined with medication for ulcerative colitis with damp-heat 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB OBJECTIVE: To explore the effects and mechanism of acupuncture at Zusanli (ST 36) 
   combined with oral administration of Gexia Zhuyu decoction on damp-heat 
   ulcerative colitis at active phase. METHODS: One hundred and twenty cases of 
   damp-heat ulcerative colitis at active phase, by using random draw method, were 
   divided into an observation group and a control group, 60 cases in each one. 
   Patients in the control group were treated with basic treatment combined with 
   oral administration of Gexia Zhuyu decoction. Based on this, patients in the 
   observation group were additionally treated with acupuncture at Zusanli (ST 36). 
   The treatment was given both for 14 days. The efficacy, each symptom score, serum 
   interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis 
   factor-alpha (TNF-alpha) were observed. RESULTS: (1) After treatment, the total 
   effective rate was 98.3% (59/60) in the observation group, which was 
   significantly higher than 86.7% (52/60) in the control group (P<0.05). ( The 
   improvement rates of ulceration, edema, erosion and polyp in the observation 
   group were obviously higher than those in the control group (all P<0.05). (3) 
   After treatment, the symptom scores of diarrhea, bloody purulent stool, abdominal 
   pain, tenesmus as well as inflammatory factors of IL-1beta, IL-6 and TNF-alpha 
   were all improved compared with those before treatment in the two groups (all 
   P<0.05); the differences between the observation, group and control group were 
   statistically significant (all P<0.05). (4) During the 3-month follow up visit, 
   the recurrence rate was 1.7% (1/59) in the observation group, which was 
   significantly lower than 11.5% (6/52) in the control group (P<0.05). CONCLUSION: 
   The Gexia Zhuyu decoction combined with acupuncture at Zusanli (ST 36) could 
   effectively improve efficacy, reduce recurrence rate, relieve clinical symptoms 
   and prompt recovery of mucous membrane in patients with damp-heat ulcerative 
   colitis at active phase, which is related with reducing the expression of 
   inflammation.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD AUG 11
PY 2015
VL 35
IS 5
BP 435
EP 8
DI 
PG -427
WC Acupuncture Points; Acupuncture Therapy; Adult; Aged; Colitis, Ulcerative; drug therapy; Combined Modality Therapy; Drugs, Chinese Herbal; administration & dosage; Humans; Interleukin-1beta; genetics; Interleukin-6; genetics; Male; Middle Aged; Tumor Necrosis Factor-alpha; genetics; Young Adult
UT PubMed:26255512
PM 26255512
DA 2015-08-11
ER

PT J
AU Liu, J
   Huang, Z
   Zhang, GH
AF Liu, Jing
   Huang, Zheng
   Zhang, Gen-Hong
TI [Involvement of NF-κB signal pathway in acupuncture treatment of patients with 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acupuncture; Inflammatory factor; NF-κB signaling pathway; Rheumatoid arthritis
AB OBJECTIVE: To observe the effect of acupuncture on nuclear factor 
   kappa-B(NF-κB)signaling pathway in patients with rheumatoid arthritis (RA), so as 
   to explore the mechanism of acupuncture in the treatment of RA. METHODS: A total 
   of 120 RA patients admitted to the Xinyu Hospital of Traditional Chinese Medicine 
   in Jiangxi Province from June 2018 to June 2019 were selected and randomly 
   divided into a control group and a treatment group, with 60 cases in each group. 
   The patients in the control group received oral administration of Methotrexate, 
   (10-15) mg/time, once a week, for a total of 10 weeks. On the basis of oral 
   administration of Methotrexate, patients in the treatment group were treated with 
   acupuncture at Quchi(LI11), Zusanli(ST36), Taichong(LR3), Hegu(LI4), 
   Shenshu(BL23), Geshu(BL17) and Dazhui(GV14) once daily. The treatment was 
   conducted 6 consecutive times as a course for 10 courses. The serum C-reactive 
   protein (CRP) and erythrocyte sedimentation rate (ESR), pain visual analog scale 
   (VAS) score, number of swollen joints, and morning stiffness time before and 
   after treatment were compared between the two groups. The expression levels of 
   inflammatory related factors and NF-κB p65 protein in the synovial fluid were 
   detected by enzyme-linked immunosorbent assay and Western blot separately. 
   RESULTS: After treatment, both groups had significant decrease in CRP, ESR, VAS 
   score, number of swollen joints and morning stiffness time, levels of NF-κB p65 
   protein, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 
   (P<0.05) in the joint fluid, and increase in transforming growth factor-β (TGF-β) 
   and IL-10 (P<0.05). After treatment, compared with the control group, CRP, ESR, 
   VAS score and morning stiffness time, and the levels of NF-κB p65, TNF-α, IL-1β 
   and IL-6 in the treatment group were down-regulated (P<0.05), while the level of 
   TGF-β was up-regulated (P<0.05). The treatment group had a higher total effective 
   rate than the control group［85.0%(51/60) vs 75.0%(45/60), P<0.05］. CONCLUSION: 
   Acupuncture can inhibit the expression of NF-κB signaling pathway in RA patients, 
   regulate the levels of related inflammatory factors, and thus improve the 
   symptoms of RA patients.
C1 Department of Acupuncture and Moxibustion, Xinyu Hospital of Traditional Chinese Medicine, Xinyu 338025, Jiangxi Province, China.
   Department of Acupuncture and Moxibustion, Xinyu Hospital of Traditional Chinese Medicine, Xinyu 338025, Jiangxi Province, China.
   Department of Acupuncture and Moxibustion, Xinyu Hospital of Traditional Chinese Medicine, Xinyu 338025, Jiangxi Province, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD DEC 4
PY 2020
VL 45
IS 11
BP 914
EP 9
DI 10.13702/j.1000-0607.190848 
PG -905
WC Acupuncture Therapy; Arthritis, Rheumatoid; genetics; Humans; Methotrexate; NF-kappa B; genetics; Signal Transduction
UT PubMed:33269836
PM 33269836
DA 2020-12-04
ER

PT J
AU Zhao, L
   Li, X
   Shi, Z
AF Zhao, Li
   Li, Xueqing
   Shi, Zhimin
TI [Clinical observation on severe acute pancreatitis treated with 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE IL-6; Point BL 25 (Dachangshu); Point ST 37 (Shangjuxu); TNF-α; amylase; electroacupuncture; severe acute pancreatitis
AB OBJECTIVE: To observe the clinical therapeutic effects on severe acute 
   pancreatitis (SAP) treated with electroacupuncture (EA), sparse-dense wave and 2 
   Hz/15 Hz, at Dachangshu (BL 25) and Shangjuxu (ST 37) assisting ulinastetin and 
   explore the effective therapeutic method for SAP. METHODS: A total of 120 
   patients of SAP were randomized into an observation group and a control group, 60 
   cases in each one. In the control group, the routine western medicine was adopted 
   with the intravenous drip with ulinastatin. In the observation group, on the 
   basis of the treatment as the control group, EA was applied at Dachangshu (BL 25) 
   and Shangjuxu (ST 37). The treatment was given once every day, 20 min each time. 
   The treatment was 2 weeks in the two groups. The recovery time of defecation, the 
   recovery time of bowel sound, the remission time of abdominal pain and the 
   hospitalization time were recorded in the patients of the two groups. The changes 
   in the tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and amylase, as 
   well as the scores in the acute physiology and chronic health evaluation Ⅱ 
   (APACHE Ⅱ) were compared in the patients of the two groups before treatment, and 
   on the 3rd, 8th and 14th days of treatment. The therapeutic effects, the cases of 
   surgical transfer or the cases of the transfer of intensive care unit (ICU) were 
   compared between the two groups. RESULTS: The recovery time of defecation, the 
   recovery time of bowel sound and the remission time of abdominal pain, as well as 
   the hospitalization time in the observation group were shorter than those in the 
   control group (all P <0.05). The levels of TNF-α, IL-6 and amylase, as well as 
   the scores of APACHE Ⅱ on the 3rd, 8th and 14th days of treatment were all 
   reduced as compared with those before treatment in the two groups (all P <0.05). 
   The results in the observation group were lower than those in the control group 
   (all P <0.05). The total effective rate was 95.0% (57/60) in the observation 
   group, better than 81.7% (49/60) in the control group (P <0.05). There were 1 
   case of surgical transfer and 0 case in ICU transfer in the observation group, 3 
   cases of surgical transfer and 2 cases in ICU transfer in the control group, 
   indicating the significant differences between the two groups (both P <0.05). . 
   CONCLUSION: EA at Dachangshu (BL 25) and Shangjuxu (ST 37) displays the 
   satisfactory accessory therapeutic effects on SAP treated with ulinastatin.
C1 Department of Digestive Internal Medicine, Tangshan Worker Hospital, Tangshan 063000, Hebei Province, China.
   School of TCM, North China University of Science and Technology, Tangshan 063000, Hebei Province.
   Department of Spleen and Stomach Disorder, Tangshan Chinese Medicine Hospital.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD FEB 24
PY 2018
VL 38
IS 2
BP 132
EP 6
DI 10.13703/j.0255-2930.2018.02.005 
PG -126
WC Acupuncture Points; Amylases; blood; Combined Modality Therapy; Electroacupuncture; Glycoproteins; therapeutic use; Humans; Interleukin-6; blood; Pancreatitis; therapy; Tumor Necrosis Factor-alpha; blood
UT PubMed:29473354
PM 29473354
DA 2018-02-24
ER

PT J
AU Gilmour, J
   Harrison, C
   Asadi, L
   Cohen, MH
   Vohra, S
AF Gilmour, Joan
   Harrison, Christine
   Asadi, Leyla
   Cohen, Michael H
   Vohra, Sunita
TI Informed consent: advising patients and parents about complementary and 
SO Pediatrics
LA English
DT Journal Article
AB Although research on complementary and alternative medicine (CAM) therapies is 
   still limited, systematic reviews have revealed sufficient evidence to conclude 
   that CAM can be effective for certain conditions. In this article we discuss 
   clinicians' responsibilities to inform parents/patients about CAM alternatives 
   and use the example of acupuncture for chemotherapy-induced nausea and vomiting. 
   Chemotherapy-induced nausea and vomiting remain significant adverse effects of 
   cancer therapy, and some patients cannot find relief with standard therapies. 
   When making decisions for a child with a life-threatening illness, parents must 
   consider all reasonable options and decide what is in the child's best interests. 
   A physician's failure to provide parents with relevant information regarding 
   therapies with the prospect of therapeutic benefit impedes their ability to make 
   an informed decision. Physicians have the ethical duty of beneficence; they must 
   be aware of current research in pain and symptom management and other aspects of 
   care. A physician's duty of care does not necessarily include the obligation to 
   provide information about therapies outside the range of conventional treatment 
   or those not yet supported in the medical literature. However, as CAM therapies 
   such as acupuncture become better studied and their safety and efficacy are 
   established, the scope of disclosure required may expand to include them. The 
   legal and ethical obligation to obtain informed consent to treatment requires 
   disclosure and discussion of therapies when there is reliable evidence of 
   potential therapeutic benefit. At the same time, the more limited state of 
   knowledge regarding effects of a particular therapy in the pediatric population 
   must be factored into decision-making when treating a child.
C1 Osgoode Hall Law School, York University, Toronto, Ontario, Canada.
NR 0
TC 0
SN 1098-427
EI 
J9 Pediatrics
PD NOV 9
PY 2011
VL 128 Suppl 4
IS 
BP S187
EP 92
DI 10.1542/peds.2010-2720H 
PG 1
WC Acupuncture Therapy; ethics; Antineoplastic Agents; adverse effects; Canada; Child; Complementary Therapies; ethics; Disclosure; ethics; Ethics, Medical; Humans; Informed Consent; ethics; Liability, Legal; Male; Nausea; etiology; Parents; Physician-Patient Relations; Professional-Family Relations; United States; Vomiting; etiology
UT PubMed:22045862
PM 22045862
DA 2011-11-09
ER

PT J
AU Jones, KF
   Wechsler, S
   Zulewski, D
   Wood, L
AF Jones, Katie Fitzgerald
   Wechsler, Stephen
   Zulewski, David
   Wood, Lisa
TI Pharmacological and Nonpharmacological Management of Chemotherapy-Induced 
SO Journal of palliative medicine
LA English
DT Journal Article
DE chemotherapy-induced neuropathy; chronic pain; neuropathic pain; peripheral neuropathy
AB Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and 
   debilitating side effect of cancer treatment with no effective preventative 
   strategy or definitive treatment. Purpose: To synthesize empiric literature from 
   randomized controlled trials (RCTs) of pharmacological and nonpharmacological 
   management of CIPN. Data Sources: Articles published between January 1, 2010, and 
   February 28, 2021, were identified using keywords searching Medline, PubMed, 
   CINAHL, Web of Science, Cochrane Library, and Embase. Study Selection: RCTs that 
   recruited individuals who were post-chemotherapy and experienced persistent CIPN 
   symptoms. Data Extraction and Synthesis: Three independent reviewers screened a 
   total of 2023 abstracts. After screening, full-text review, and quality 
   appraisal, 22 articles were included in this review. Data related to study 
   design, participant characteristics, interventions, controls, outcome measures, 
   and relevant findings were extracted from full texts. Descriptive quantitative 
   summaries were calculated and narrative analysis was performed. Results: Of the 
   22 studies, 4 investigated pharmacologic treatments, 2 compared acupuncture to 
   pharmacologic treatments, and 16 studies examined nonpharmacologic treatments. 
   Pharmacologic studies reported mixed results with evidence of participant 
   response varying by history of chemotherapeutic agent. Acupuncture, 
   exercise/physical therapy, and neurofeedback appear to be effective treatments 
   for CIPN. Evidence regarding biophysical agents and cognitive-behavioral therapy 
   is equivocal. Scrambler therapy is not supported. Limitations: Studies included 
   in this review share several limitations, including widely variable outcome 
   measures, small and demographically homogenous samples, and nonstandardized 
   treatment protocols. Conclusion: This scoping review summarized the current body 
   of high-quality RCTs investigating treatment for CIPN. The majority of studies in 
   this review reports benefits of pharmacologic and nonpharmacologic interventions, 
   although management may require a multipronged approach and should be tailored to 
   the individual. Clinical implications are proposed and suggestions made for 
   future research include implementation of standardized intervention protocols, 
   use of outcome measures representative of the spectrum of CIPN symptoms, and 
   stratification by the chemotherapeutic agent.
C1 William F. Connell School of Nursing, Boston College, Chestnut Hill, Massachusetts, USA.
   Massachusetts General Hospital Institute for Health Professionals, School of Rehabilitation Science, Boston, Massachusetts, USA.
   William F. Connell School of Nursing, Boston College, Chestnut Hill, Massachusetts, USA.
   William F. Connell School of Nursing, Boston College, Chestnut Hill, Massachusetts, USA.
NR 0
TC 0
SN 1557-774
EI 1096-621
J9 J Palliat Med
PD FEB 8
PY 2022
VL 25
IS 6
BP 964
EP 995
DI 10.1089/jpm.2021.0512 
PG 31
WC Acupuncture Therapy; Antineoplastic Agents; adverse effects; Drug-Related Side Effects and Adverse Reactions; Humans; Peripheral Nervous System Diseases; chemically induced; Randomized Controlled Trials as Topic
UT PubMed:35128938
PM 35128938
DA 2022-02-08
ER

PT J
AU Chu, EC
   Trager, RJ
   Shum, JSF
   Lai, CR
AF Chu, Eric Chun-Pu
   Trager, Robert J
   Shum, John Sing Fai
   Lai, Colin Ritchie
TI Pancoast Tumor Presenting as Neck Pain in the Chiropractic Office: A Case Report 
SO The American journal of case reports
LA English
DT Review
AB BACKGROUND Pancoast tumors, also called superior sulcus tumors, are a rare type 
   of cancer affecting the lung apex. These tumors can spread to the brachial plexus 
   and spine and present with symptoms that appear to be of musculoskeletal origin. 
   CASE REPORT A 59-year-old Asian man presented to a chiropractor in Hong Kong with 
   a 1-month history of neck and shoulder pain and numbness that had been treated 
   unsuccessfully with exercise, medications, and acupuncture. He had an active 
   history of tuberculosis, which was currently treated with antibiotics, and a 
   50-pack-year history of smoking. Cervical magnetic resonance imaging (MRI) was 
   performed urgently, revealing a small cervical disc herniation thought to 
   correspond with radicular symptoms. However, as the patient did not respond to a 
   brief trial of care, a thoracic MRI was urgently ordered, revealing a large 
   superior sulcus tumor invading the upper to mid-thoracic spine. The patient was 
   referred for medical care and received radiotherapy and chemotherapy with a 
   positive outcome. A literature review identified 6 previously published cases in 
   which a patient presented to a chiropractor with an undiagnosed Pancoast tumor. 
   All patients had shoulder, spine, and/or upper extremity pain. CONCLUSIONS 
   Patients with a previously undiagnosed Pancoast tumor can present to 
   chiropractors given that these tumors may invade the brachial plexus and spine, 
   causing shoulder, spine, and/or upper extremity pain. Chiropractors should be 
   aware of the clinical features and risk factors of Pancoast tumors to readily 
   identify them and refer such patients for medical care.
C1 New Chiropractic and Physiotherapy Centre, EC Healthcare, Hong Kong, Hong Kong.
   Connor Whole Health, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
   Hong Kong Advanced Imaging, EC Healthcare, Hong Kong, Hong Kong.
   New Chiropractic and Physiotherapy Centre, EC Healthcare, Hong Kong, Hong Kong.
NR 0
TC 0
SN 1941-592
EI 
J9 Am J Case Rep
PD JUL 8
PY 2022
VL 23
IS 
BP e937052
EP e937052
DI 10.12659/AJCR.937052 
PG 1
WC Brachial Plexus; Chiropractic; Humans; Intervertebral Disc Displacement; Male; Middle Aged; Neck Pain; Pancoast Syndrome; diagnosis
UT PubMed:35797264
PM 35797264
DA 2022-07-08
ER

PT J
AU Ben-Arye, E
   Biron-Shental, T
   Rosa, WE
   Samuels, N
   Levy, O
   Keshet, Y
   Armon, S
   Gressel, O
   Kedar, R
   Messinger, A
   Lev, Ari R
   Lavie, A
   Atzil, N
   Ben, Zohar B
   Ferrer, Sokolovski C
   Solt, I
   Yaffe, H
   Shechter, Maor G
   Levy, M
   Maor-Sagie, E
   Katz, Shtern D
   Stoffman, G
   Ben, Ze'ev R
   Lahav, Sher M
   Zidenberg, B
   Sagi, S
   Schiff, E
AF Ben-Arye, Eran
   Biron-Shental, Tal
   Rosa, William E
   Samuels, Noah
   Levy, Oz
   Keshet, Yael
   Armon, Shunit
   Gressel, Orit
   Kedar, Reuven
   Messinger, Aviv
   Lev Ari, Revital
   Lavie, Anat
   Atzil, Neta
   Ben Zohar, Bosmat
   Ferrer Sokolovski, Cara
   Solt, Ido
   Yaffe, Hila
   Shechter Maor, Gil
   Levy, Moti
   Maor-Sagie, Esther
   Katz Shtern, Danit
   Stoffman, Gali
   Ben Ze'ev, Reut
   Lahav Sher, Maayan
   Zidenberg, Betty
   Sagi, Shlomi
   Schiff, Elad
TI Acupuncture in obstetrics: delivery room integrative medicine for anxiety and 
SO BMJ supportive & palliative care
LA English
DT Journal Article
DE Complementary therapy; Integrative Medicine
AB OBJECTIVES: Supportive and palliative care include non-oncology settings where 
   patients suffer from pain and quality of life-related concerns. Integrative 
   medicine plays important roles in supportive care and symptom management, 
   including Integrative Obstetric (IOb) programmes within peri-partum settings. 
   Multidisciplinary approaches may help nurse-midwives and obstetricians improve 
   patient care and associated outcomes. This study presents a national perspective 
   on IOb programmes in Israel. METHODS: A qualitative research methodology was 
   codesigned by the Society for Complementary Medicine and Society of 
   Maternal-Fetal Medicine, Israel Medical Association. A questionnaire with 17 
   open-ended questions was distributed throughout obstetrics and gynaecology 
   departments across Israel. Respondent narratives were qualitatively analysed 
   using ATLAS.Ti software for systematic coding. RESULTS: 22 senior obstetricians 
   and IOb directors across 11 centres with IOb programmes completed the 
   questionnaire. Core themes considered essential for the design and operation of 
   IOb programmes included (1) determining major goals and indications for referral, 
   primarily pain and anxiety; (2) targeting patients most likely to benefit; (3) 
   identifying barriers and enablers to implementation and communication with the 
   obstetric team; (4) designing the referral process and (5) documenting outcomes 
   and safety of the IOb intervention in electronic medical files. CONCLUSIONS: 
   Designing and implementing IOb models of care that effectively support holistic 
   symptom management within obstetric settings requires identifying barriers and 
   enablers and establishing effective communication between obstetric and 
   integrative medical teams. Further research should explore other 
   multidisciplinary models of IOb care and structured referral development and 
   testing while assessing risks and effectiveness.
C1 Integrative Oncology Program, Oncology Service, LIN Medical Center, Haifa, Haifa District, Israel eranben@netvision.net.il.
   Meir Medical Center, Kefar Sava, Center District, Israel.
   Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
   Shaare Zedek Medical Center, Jerusalem, Jerusalem District, Israel.
   Western Galilee College, Acre, North District, Israel.
   Shaare Zedek Medical Center, Jerusalem, Jerusalem District, Israel.
   Integrative Obstetric Program, Carmel Medical Center, Haifa, Israel.
   Carmel Medical Center, Haifa, Israel.
   Sheba Medical Center, Tel HaShomer, Tel Aviv District, Israel.
   Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel.
   Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel.
   Hadassah Mount Scopus University Hospital, Jerusalem, Israel.
   Hadassah Mount Scopus University Hospital, Jerusalem, Israel.
   Rambam Health Care Campus, Haifa, Israel.
   Rambam Health Care Campus, Haifa, Israel.
   Hadassah University Medical Center Division of Obstetrics and Gynecology, Jerusalem, Israel.
   Meir Medical Center, Kefar Sava, Center District, Israel.
   Clalit Health Services, Tel Aviv-Yafo, Israel.
   Hillel Yaffe Medical Center, Hadera, Israel.
   Hillel Yaffe Medical Center, Hadera, Israel.
   Barzilai University Medical Center, Ashkelon, Israel.
   Barzilai Medical Center, Ashkelon, Israel.
   Carmel Medical Center, Haifa, Israel.
   Bnai Zion Medical Center, Haifa, Israel.
   Bnai Zion Medical Center, Haifa, Israel.
   Department of Internal Medicine, Bnai-Zion Hospital, Haifa, Israel.
NR 0
TC 0
SN 2045-436
EI 2045-435
J9 BMJ Support Palliat Care
PD APR 17
PY 2025
VL 15
IS 4
BP 535
EP 541
DI 10.1136/spcare-2025-005512 
PG 6
WC Humans; Female; Pregnancy; Integrative Medicine; methods; Pain Management; methods; Anxiety; therapy; Israel; Acupuncture Therapy; methods; Qualitative Research; Obstetrics; methods; Surveys and Questionnaires
UT PubMed:40240122
PM 40240122
DA 2025-04-17
ER

PT J
AU Chen, Y
   Li, LQ
   Wang, MH
   Li, WQ
   Zhang, Q
   Zhang, HF
   Ge, YL
AF Chen, Yi
   Li, Li Q
   Wang, Meng H
   Li, Wen Q
   Zhang, Qian
   Zhang, Hai F
   Ge, Yan L
TI Elevated D-Dimer Combined with Persistent Acupuncture-like Chest Pain in An 
SO Clinical laboratory
LA English
DT Review
AB BACKGROUND: Pulmonary hamartoma is one of the most common benign tumors of the 
   lung, the symptoms are often atypical, so its diagnosis is not so easy. We 
   presented an elderly man with elevated D-dimer combined persistent 
   acupuncture-like chest pain misdiagnosed as pulmonary embolism finally proved as 
   lung hamartoma with secondary lung infection by bronchoscopy biopsy. METHODS: 
   Appropriate laboratory tests were carried out. The chest computed tomography (CT) 
   scan and bronchoscopy were performed for diagnosis. RESULTS: Laboratory tests 
   showed D-dimer was 2,615.88 ng/mL, the chest CT scan showed the right lung portal 
   occupying lesions accompanied by obstructive changes in the middle of the right 
   lung and mediastinal lymphade-nopathy with partial calcification. Bronchoscopy 
   showed the new spherical neoplasm in the middle of the right lung completely 
   blocked the opening of the bronchus, the surface of the neoplasm was smooth and 
   blood vessels were abundant, pathological result was lung hamartoma. CONCLUSIONS: 
   Elevated D-dimer is not a specific index of pulmonary embolism. When a patient's 
   D-dimer rise combined with severe chest pain, the physician should be wary of 
   pulmonary embolism, myocardial infarction, aortic dissection, and other 
   emergencies, and should also take into account serious infections, tumors, and 
   other diseases. Diagnosis needs further related examination. Chest CT scan has 
   guidance function, and when the chest CT scan suggests the occupying lesion, the 
   pathology examination is the key to identify the benign tumor.
NR 0
TC 0
SN 
EI 1433-651
J9 Clin Lab
PD SEP 19
PY 2019
VL 65
IS 9
BP 
EP 
DI 10.7754/Clin.Lab.2019.190306 
PG 0
WC Aged; Bronchoscopy; Chest Pain; diagnosis; Diagnosis, Differential; Diagnostic Errors; Fibrin Fibrinogen Degradation Products; metabolism; Hamartoma; diagnosis; Humans; Lung Neoplasms; diagnosis; Male; Pulmonary Embolism; diagnosis; Respiratory Tract Infections; diagnosis
UT PubMed:31532091
PM 31532091
DA 2019-09-19
ER

PT J
AU Bae, K
   Lamoury, G
   Carroll, S
   Morgia, M
   Lim, S
   Baron-Hay, S
   Shin, IS
   Park, SJ
   Oh, B
AF Bae, Kyeore
   Lamoury, Gillian
   Carroll, Susan
   Morgia, Marita
   Lim, Stephanie
   Baron-Hay, Sally
   Shin, In-Soo
   Park, So-Jung
   Oh, Byeongsang
TI Comparison of the clinical effectiveness of treatments for aromatase 
SO Critical reviews in oncology/hematology
LA English
DT Journal Article
DE Aromatase inhibitor; Breast cancer; Network meta-analysis; Pain; Quality of life
AB Aromatase inhibitor-induced arthralgia (AIA) contributes to poor adherence of 
   aromatase inhibitor therapies in patients with breast cancer. A systematic review 
   using network meta-analysis (NMA) was conducted to examine the clinical 
   effectiveness of multiple therapies and rank probabilities for the management of 
   AIA. Randomized controlled trials (RCTs) assessing treatments for AIA in 
   postmenopausal women with stage 0-III hormone receptor-positive breast cancer 
   were searched from inception to October 2021. The main NMA involved 1516 
   participants from 17 RCTs. Acupuncture was the highest ranked intervention to 
   improve pain intensity followed by sham acupuncture, multicomponent herbal 
   medicine, exercise, duloxetine, vitamin D, omega-3 fatty acids, physical therapy, 
   testosterone, and inactive controls. Single natural products were inferior to 
   controls. The current review provides new insights into the management of AIA in 
   breast cancer survivors for increased survival and can be utilized to make 
   evidence-based decisions regarding treatment.
C1 Integrative Cancer Center, Doban Hospital, Seoul, 03170, Republic of Korea
   Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, Sydney,New South Wales, 2065, Australia. 
   Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, 2065, Australia
   Faculty of Medicine and Health, University ofSydney, Sydney, New South Wales, 2006, Australia. 
   Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, 2065, Australia
   Faculty of Medicine and Health, University ofSydney, Sydney, New South Wales, 2006, Australia. 
   Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, 2065, Australia. 
   Medical Oncology Department, Macarthur Cancer Therapy Centre, Campbelltown, New South Wales, 2560, Australia
   Western Sydney University, Campbelltown, New SouthWales, 2560, Australia. 
   Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, 2065, Australia
   Faculty of Medicine and Health, University ofSydney, Sydney, New South Wales, 2006, Australia. 
   Department of Graduate School of Education, Dongguk University, Seoul, 04620, Republic of Korea. 
   Department of Internal Medicine, Korean Medicine Hospital of Pusan National University, Yangsan, Gyeongnam, 50612, Republic of Korea. 
   Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, 2065, Australia
   Faculty of Medicine and Health, University ofSydney, Sydney, New South Wales, 2006, Australia. 
EM yeong.oh@sydney.edu.au
NR 0
TC 0
SN 1879-046
EI 
J9 Crit Rev Oncol Hematol
PD DEC 20
PY 2022
VL 181
IS 
BP 103898
EP 103898
DI 10.1016/j.critrevonc.2022.103898 
PG 0
WC Female; Humans; Aromatase Inhibitors; adverse effects; Arthralgia; chemically induced; Treatment Outcome; Breast Neoplasms; complications
UT PubMed:36535489
PM 36535489
DA 2022-12-20
ER

PT J
AU Ko, MM
   Jang, S
   Lee, JA
   Kang, BK
   Jung, J
AF Ko, Mi Mi
   Jang, Soobin
   Lee, Ju Ah
   Kang, Byung Kab
   Jung, Jeeyoun
TI Blood Stasis Therapy for Traumatic Injury: A Prospective, Single-Arm, Pre-Post 
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
DE Traditional Korean Medicine; blood stasis; diagnosis; pain; perfusion index; traumatic injury
AB OBJECTIVES: Blood stasis is an important pathophysiologic concept in Traditional 
   East Asian Medicine. It has been considered to be a pathogenic factor in chronic 
   and incurable conditions such as pain, infertility, cancer, coronary heart 
   disease, and others. The aim of this study was to investigate the effects of pain 
   reduction by blood stasis treatment for blood stasis syndromes with traumatic 
   injury. METHODS: A single-center prospective pretest-post-test pilot study 
   included 73 patients with a trauma that occurred within the past 2 weeks who were 
   admitted into Jaseng Hospital of Korean Medicine from August 2015 through 
   December 2015. Of the 50 patients analyzed in this study, 42 were women (mean 
   age, 33.52). Triple Energizer-reinforcing Saam acupuncture set, herbal medicine 
   (Dangkwisoo-san), and wet cupping on tender point, which are Korean medical 
   therapies generally executed to treat post-traumatic pain, were performed. The 
   patients had to receive at least six sessions of treatment during the 2 weeks, 
   with subsequent treatment being performed within 3 ± 1 days after the previous 
   treatment. Numeric rating scale (NRS) score and general pain severity indicator 
   was measured as a primary outcome measure. The blood stasis questionnaire, 
   oximetry, and patient's satisfaction were also measured. RESULTS: The mean size 
   of subcutaneous bleeding (width and length) and NRS score as a general pain 
   indicator significantly decreased over the visits (all p < 0.01, visit 1 vs. 
   visit 6). Among the blood stasis symptoms in the questionnaire, 11 blood stasis 
   indicators significantly decreased (all p < 0.05). The patients showed 
   significant improvement in the minimum and maximum value of peripheral perfusion 
   index after the treatment (p = 0.011 and p = 0.15, respectively). CONCLUSIONS: 
   This study reveals that blood stasis treatment may help improve the pain of 
   patients with traumatic injury by enhancing the peripheral blood flow. The 
   significant results observed in this study support some evidence of the theories 
   of diagnosing blood stasis pattern and treatments of that pattern in Korean 
   Medicine.
C1 1 Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
   1 Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
   2 Department of Korean Internal Medicine, College of Korean Medicine, Gachon University, Seongnam, Republic of Korea.
   1 Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
   1 Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
NR 0
TC 0
SN 1557-770
EI 
J9 J Altern Complement Med
PD AUG 30
PY 2018
VL 25
IS 3
BP 359
EP 365
DI 10.1089/acm.2018.0134 
PG 6
WC Acupuncture Therapy; Adult; Contusions; therapy; Female; Humans; Male; Medicine, Korean Traditional; methods; Pain Management; methods; Pilot Projects; Plant Preparations; therapeutic use; Prospective Studies; Treatment Outcome; Wounds and Injuries; therapy; Young Adult
UT PubMed:30156424
PM 30156424
DA 2018-08-30
ER

PT J
AU Li, M
   Jiang, X
   Gai, X
   Dai, M
   Li, M
   Wang, Y
   Wang, H
AF Li, Mengqi
   Jiang, Xiaobo
   Gai, Xiangmu
   Dai, Mengyao
   Li, Mengyuan
   Wang, Yanxin
   Wang, Hongfeng
TI CiteSpace-based visual analysis on transcutaneous electrical acupoint stimulation 
SO Medicine
LA English
DT Review
AB To systematically present an overview of randomized controlled trials on 
   transcutaneous electrical acupoint stimulation (TEAS) using bibliometric methods, 
   and describe the role and mechanisms of TEAS in most prevalent diseases. Relevant 
   literature was searched in China National Knowledge Infrastructure, Wanfang Data, 
   VIP, SinoMed, PubMed, and Web of Science. The literature was imported and 
   screened into NoteExpress, screened according to inclusion and exclusion 
   criteria, and analyzed using Excel and CiteSpace 6.3R1 software. A total of 1296 
   documents were included. The number of publications increased annually after 
   2012. Junlu Wang was the most prolific author. The main research institutions 
   were Peking University, The Third Affiliated Hospital of Zhejiang Chinese Medical 
   University, Shuguang Hospital, and Tongde Hospital of Zhejiang Province. The 
   research hotspots in this field include perioperative care, cancer, pain 
   management, and stroke, primarily focusing on analgesia, immune enhancement, 
   antihypertension, and reduction of gastrointestinal disorders. The main 
   regulatory mechanisms of TEAS include the control of inflammation, oxidative 
   stress, and regulation of the autonomic nervous system. TEAS is most widely used 
   in the elderly, with PC6, ST36, and LI4 being the most frequently studied 
   acupoints in clinical randomized controlled trials. The concept of accelerated 
   rehabilitation is gradually being applied to TEAS, representing an emerging trend 
   for future development. Clinical research on TEAS is rapidly developing, with a 
   focus on applications in cancer and perioperative care. Future research should 
   expand collaboration and conduct high-level clinical and mechanistic studies, 
   which will contribute to the development of standardized protocols and clinical 
   practice.
C1 College of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
   College of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
   College of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
   College of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
   Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
   Department of Cardiovascular Rehabilitation, The Third Clinical Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
   Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD OCT 28
PY 2024
VL 103
IS 41
BP e39893
EP e39893
DI 10.1097/MD.0000000000039893 
PG 1
WC Humans; Transcutaneous Electric Nerve Stimulation; methods; Acupuncture Points; Randomized Controlled Trials as Topic; Perioperative Care; methods
UT PubMed:39465871
PM 39465871
DA 2024-10-28
ER

PT J
AU Papadopoulou, M
   Stamou, M
   Bakalidou, D
   Moschovos, C
   Zouvelou, V
   Zis, P
   Tzartos, J
   Chroni, E
   Michopoulos, I
   Tsivgoulis, G
AF Papadopoulou, Marianna
   Stamou, Magda
   Bakalidou, Daphne
   Moschovos, Christos
   Zouvelou, Vasiliki
   Zis, Panagiotis
   Tzartos, John
   Chroni, Elisabeth
   Michopoulos, Ioannis
   Tsivgoulis, Georgios
TI Non-pharmacological Interventions on Pain and Quality of Life in Chemotherapy 
SO In vivo (Athens, Greece)
LA English
DT Journal Article
DE Chemotherapy-induced polyneuropathy; acupuncture; non-pharmacological interventions; pain; quality of life; review; yoga
AB BACKGROUND/AIM: Chemotherapy-induced peripheral neuropathy (CIPN) is a common 
   side effect of cancer treatment, resulting in pain, numbness, instability, and 
   thus affecting quality of life (QoL), occasionally leading to discontinuation of 
   chemotherapy. Pharmacological treatments are not sufficient. Non-pharmacological 
   interventions (NPIs) have also been tried. This study aimed to systematically 
   review the efficacy of NPIs on pain and QoL in patients suffering from CIPN. 
   MATERIALS AND METHODS: The databases searched were Pubmed, Cohrane, and Scopus 
   for randomized controlled trials (RCTs) published in the last 5 years 
   (2017-2022). Studies were considered eligible, if they assessed adult patients 
   suffering from CIPN because of any chemotherapeutic drug for any type and any 
   stage of cancer and if study protocols included non-pharmacological intervention 
   with a structured protocol. RESULTS: A total of 1,496 records were identified. 
   Finally, 10 RCTs including 495 patients (253 in the intervention group and 242 in 
   the control group) were included for meta-analysis. Intervention protocols 
   included acupuncture (n=6), exercise (n=3), and yoga (n=1). NPIs significantly 
   reduced neuropathic pain. However, the effect on QoL was not significant. 
   CONCLUSION: NPIs are beneficial in the treatment of pain in patients with CIPN 
   but their impact on QoL is not statistically supported. Larger sample sizes, more 
   homogenous in outcome measures and interventions are needed to further explore 
   NPIs' efficacy on CIPN symptoms.
C1 Department of Physiotherapy, University of West Attica, Athens, Greece
   marpapgr@yahoo.co.uk mpapad@uniwa.gr.
   Second Department of Neurology, Medical School, National and Kapodistrian 
   Department of Physiotherapy, University of West Attica, Athens, Greece.
   Department of Physiotherapy, University of West Attica, Athens, Greece.
   Second Department of Neurology, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
   First Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition University Hospital, Athens, Greece.
   Second Department of Neurology, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
   Second Department of Neurology, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
   Department of Neurology, School of Medicine, University of Patras, Patras, Greece.
   Second Department of Psychiatry, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
   Second Department of Neurology, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
NR 0
TC 0
SN 1791-754
EI 0258-851
J9 In Vivo
PD JAN 3
PY 2023
VL 37
IS 1
BP 47
EP 56
DI 10.21873/invivo.13053 
PG 9
WC Adult; Humans; Antineoplastic Agents; therapeutic use; Neoplasms; complications; Polyneuropathies; therapy; Neuralgia; chemically induced; Quality of Life
UT PubMed:36593011
PM 36593011
DA 2023-01-03
ER

PT J
AU Yang, JR
   Zhang, JP
   Yu, JC
   Han, JX
AF Yang, Jun-Rion
   Zhang, Jian-Ping
   Yu, Jian-Chun
   Han, Jing-Xian
TI [Lumbar disc herniation treated with qi pathway intervention and spinal 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
AB OBJECTIVE: To compare the efficacy difference in the treatment of lumbar disc 
   herniation (LDH) between the comprehensive therapy of qi pathway intervention and 
   the spinal adjustment and the conventional therapy of acupuncture and Tuina and 
   explore the analgesic mechanism. METHODS: Seventy-one cases were randomized into 
   a comprehensive therapy group (36 cases) and a conventional therapy group (35 
   cases). In the comprehensive therapy group, the acupoints in the region of 
   abdominal qi pathway were selected and stimulated manually with both hands. In 
   combination, the spinal adjustment therapy was applied. In the conventional 
   therapy group, Shenshu (BL 23), Dachangshu (BL 25), Huantiao (GB 30) and Chengfu 
   (BL 36) on the affected side were selected and stimulated with the conventional 
   needling technique. Additionally, the routine Tuina therapy was applied. Before 
   and after treatment, the visual analogue scale (VAS), Oswestry disability index 
   (ODI) questionnaire, the health related quality of life (SF-36) questionnaire and 
   the level of serum tumor necrosis factor (TNF-alpha) were adopted to determine 
   analgesic effect and clinical efficacy. RESULTS: In the comprehensive therapy 
   group, the curative and effective rate was 91.7% (33/36), which was apparently 
   superior to 77.1% (27/35) in the conventional therapy group (P < 0.05). The 
   analgesic effect in the first 10 treatments in the comprehensive therapy group 
   was apparently superior to that in the conventional therapy group (P < 0.05). ODI 
   after treatment was improved significantly in both groups (both P < 0.05), in 
   which the result in the comprehensive therapy group was superior to that in the 
   conventional therapy group (P < 0.05). After treatment, the SF-36 values of gener 
   al health, bodily pain, physiological functioning, social functioning and 
   emotional functioning in the comprehensive therapy group were superior to that in 
   the conventional therapy group (all P < 0.05). After 15 treatments, the level of 
   serum TNF-alpha in the comprehensive therapy group was lowered as compared with 
   that before treatment and lower apparently than that in the conventional therapy 
   group (P < 0.05); after 30 treatments, it was also lower than that in 
   conventional therapy group (P < 0.05). CONCLUSION: In the guide of the theory of 
   qi pathway, the comprehensive therapy of acupuncture and spinal adjustment 
   intervention achieves the quick and good efficacy on LDH as compared with the 
   conventional acupuncture and Tuina and improves the quality of life for the 
   patients to certain extent. The analgesic effect of this therapy is relevant with 
   the decrease of serum TNF-alpha.
C1 Department of Acupuncture and Moxibustion, Affiliated HOsiptal of Tongren Occupation Technical College, Tongren 554300, Guizhou Province, China.yangjunxiong_320@163.com
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUL 4
PY 2013
VL 33
IS 4
BP 289
EP 93
DI 
PG -196
WC Acupuncture Points; Acupuncture Therapy; Adult; Aged; Female; Humans; Intervertebral Disc Displacement; blood; Male; Manipulation, Spinal; Middle Aged; Qi; Treatment Outcome; Tumor Necrosis Factor-alpha; blood; Young Adult
UT PubMed:23819224
PM 23819224
DA 2013-07-04
ER

PT J
AU Wu, C
   Yang, JF
   Zhang, Q
   Liu, W
   Liao, K
   Hu, B
AF Wu, Chuncheng
   Yang, Juliana F
   Zhang, Qiongying
   Liu, Wei
   Liao, Ke
   Hu, Bing
TI Successful cholangioscopic electrocoagulation for biliary papillomatosis: Report 
SO Gastroenterologia y hepatologia
LA spa
DT Journal Article
DE Biliary papillomatosis; Cholangioscopic; Colangioscopia; Electrocoagulación; Electrocoagulation; Papilomatosis biliar
AB BACKGROUND: Biliary papillomatosis is a rare type of papillomatosis. Depending on 
   the location of the disease, radical surgical resection or liver transplants are 
   the treatment of choice. These radical surgical options may be unrealistic in 
   patients who are not surgical candidates or who are unwilling to consider 
   surgery. AIMS: To evaluate the effectiveness of endoscopic electrocoagulation for 
   the biliary papillomatosis. METHODS: In this case series, we report six patients 
   with unresectable biliary papillomatosis who underwent cholangioscopic 
   electrocoagulation using needle knife and their clinic follow up information. 
   RESULTS: After patients received cholangioscopy with electrocoagulation of the 
   residual biliary papilloma, the daily T-tube drainage volume increased to 
   200-400ml with improvement in the drainage content and significant relief of 
   clinical symptoms, such as jaundice and abdominal pain. CONCLUSION: This method 
   of using electrocoagulation to directly target and destroy tumor tissue is a safe 
   and effective alternative for those with unresectable disease, and this method 
   has shown to enhance T-tube drainage volume and improve patients' overall 
   clinical symptoms.
C1 Department of Gastroenterology, West China Hospital, Sichuan University, China.
   Department of Internal Medicine, Division of Digestive and Liver Diseases, The Vanderbilt University Medical Center, Nashville, TN, USA.
   Department of Gastroenterology, West China Hospital, Sichuan University, China.
   Department of Gastroenterology, West China Hospital, Sichuan University, China.
   Department of Gastroenterology, West China Hospital, Sichuan University, China.
   Department of Gastroenterology, West China Hospital, Sichuan University, China. 
EM hubingnj@163.com
NR 0
TC 0
SN 
EI 0210-570
J9 Gastroenterol Hepatol
PD FEB 23
PY 2021
VL 44
IS 8
BP 546
EP 551
DI 10.1016/j.gastrohep.2020.12.012 
PG 5
WC Abdominal Pain; etiology; Aged; Bile Duct Neoplasms; complications; Cholangitis; etiology; Drainage; instrumentation; Electrocoagulation; methods; Endoscopy, Digestive System; Female; Humans; Jaundice; etiology; Male; Middle Aged; Pancreatitis; etiology; Papilloma; complications
UT PubMed:33617929
PM 33617929
DA 2021-02-23
ER

PT J
AU Narayanan, S
   Liu, W
   Lopez, G
   Fellman, B
   Reddy, A
   Subbiah, IM
   Cohen, L
   Bruera, E
AF Narayanan, Santhosshi
   Liu, Wenli
   Lopez, Gabriel
   Fellman, Bryan
   Reddy, Akhila
   Subbiah, Ishwaria M
   Cohen, Lorenzo
   Bruera, Eduardo
TI Practice Patterns on the Incorporation of Integrative Medicine Into the Oncologic 
SO Integrative cancer therapies
LA English
DT Journal Article
DE cancer; complementary and alternative treatments; implementation research; integrative medicine; integrative oncology; patient reported outcomes
AB BACKGROUND: With rising interest in complementary approaches to symptom 
   management, awareness of real-world practice patterns in the incorporation of 
   integrative oncology (IO) into cancer care is limited. Therefore, we examined the 
   reasons for referral, symptom burdens, and clinical outcomes for cancer patients 
   who underwent initial IO consultations. METHODS: The records of adult patients 
   with cancer who underwent initial outpatient IO consultations at our cancer 
   center for a representative 10-day period at the start of each month for 12 
   months starting January 1, 2017, were reviewed retrospectively. Patient 
   demographic and medical characteristics and outpatient IO consultation details, 
   including patient-reported outcome measures of symptom burden, were extracted. 
   Descriptive summary statistics and logistic regression were used to analyze the 
   data. RESULTS: Among the 473 study patients, 71% were women, breast cancer (42%) 
   was the most common cancer type, and 31% had metastatic cancer. Referring 
   clinicians listed an integrative approach (57%) as the most common reason for 
   referral, followed by diet (26%), pain (19%), discussion of herbs and supplements 
   (18%), and stress (18%). In comparison, patients listed their primary concerns as 
   diet (16%), pain (15%), and an integrative approach to overall health (11%). 
   After the IO consultations, the highest likelihood of subsequent recommendations 
   were acupuncture for hot flashes (odds ratio [OR], P = .002) or peripheral 
   neuropathy (OR = 6.59, P < .001), oncology massage for pain (OR = 3.04, 
   P < .001), psychology referral for patient's self-reported anxiety (OR = 2.35, 
   P < .001), and mind-body therapies for stress (OR = 2.57, P < .001). CONCLUSION: 
   Cancer patients' top concerns regarding IO consultation may not always match 
   providers' reasons for referral. Longitudinal data analysis is needed to 
   determine the effect of integrative interventions on symptom burden.
C1 The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD NOV 18
PY 2023
VL 22
IS 
BP 15347354231213045
EP 15347354231213045
DI 10.1177/15347354231213045 
PG 1
WC Adult; Humans; Female; Male; Integrative Medicine; Retrospective Studies; Medical Oncology; Breast Neoplasms; therapy; Pain
UT PubMed:37978821
PM 37978821
DA 2023-11-18
ER

PT J
AU Haoyang, WU
   Yuan, L
   Yuzhou, C
   Yizhou, X
   Lei, Z
   Yang, YU
   Xiaohong, F
AF Haoyang, W U
   Yuan, Liu
   Yuzhou, Chen
   Yizhou, Xie
   Lei, Zhong
   Yang, Y U
   Xiaohong, Fan
TI Effect of pestle needle therapy on the posterior cervical muscle in a rabbit 
SO Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
LA English
DT Journal Article
DE TOR serine-threonine kinases; apoptosis; autophagy; pestle needle; phosphatidylinositol 3-kinase; proto-oncogene proteins c-akt; spondylosis
AB OBJECTIVE: To investigate the effect of pestle needle therapy (PNT) on the 
   posterior cervical muscle (PCM) in a rabbit model of cervical spondylosis (CS) 
   and explore the underlying mechanisms. METHODS: Rabbits were divided into 
   control, CS models I and II (CS1 and CS2), electroacupuncture (EA), PNT I and II 
   (PN1 and PN2), activator (AVT), and PNT combined with activator (C-AVT) groups. A 
   long-term neck immobilization technique was used to establish a rabbit model of 
   CS. Following completion of modeling, the EA group received electroacupuncture 
   intervention, whereas the CS1, CS2, and C-AVT groups received PNT intervention. 
   The AVT and C-AVT groups received local 740 Y-P injections into the PCM daily. 
   The inflammatory injury to PCM was evaluated based on pain threshold, 
   morphological changes, and interleukin (IL)-1β, IL-6, and tumor necrosis factor 
   (TNF)-α levels. PCM fibrosis was evaluated by measuring the positive area (PA) of 
   collagen fibrils (CFs) and collagen type 1 alpha 1 (Col1α1) using Masson's and 
   immunohistochemical staining. Terminal deoxynucleotidyl transferase-mediated dUTP 
   nick-end labeling assay and transmission electron microscopy were used to 
   identify apoptotic cells and assess autophagy, respectively. Western blotting was 
   used to determine B-cell lymphoma-2 (Bcl-2), Bcl-2 associated X protein (Bax), 
   cysteine aspartate-specific protease (caspase)-3, sequestosome-1 (P62), 
   microtubule-associated protein light chain 3 (LC3-I/II), phosphatidylinositol 
   3-kinase (PI3K), protein kinase B (AKT), and mammalian target of rapamycin (mTOR) 
   levels. Real-time quantitative polymerase chain reaction was used to determine 
   mRNA expression levels of PI3K, AKT, mTOR, autophagy protein (ATG), and ATG7. 
   RESULTS: PNT alleviated PCM cell degeneration and necrosis, inhibited 
   inflammatory cell infiltration, decreased IL-1β, IL-6, and TNF-α levels, and 
   decreased the PA of CFs and Col1α1. In the PN1 group, cell apoptosis in the PCM 
   decreased, autophagy increased, Bcl-2 and LC3-II/I levels increased, Bax, 
   Caspase-3, and P62 levels decreased, and the mRNA expression of ATG5 and ATG7 
   increased. PNT inhibits protein and mRNA expression of PI3K, AKT, and mTOR. 
   Finally, the trend in the results of the rescue experiment was consistent with 
   previous results. CONCLUSION: PNT inhibited apoptosis and promoted autophagy of 
   PCM cells in CS rabbits and alleviated inflammation and fibrosis injury of PCM by 
   inhibiting the PI3K/AKT/mTOR pathway.
C1 College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China.
   College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China.
   College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China.
   College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China.
   Department of Orthopaedics, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
   Department of Orthopaedics, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
   Department of Orthopaedics, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
NR 0
TC 0
SN 2589-451
EI 0255-292
J9 J Tradit Chin Med
PD AUG 14
PY 2025
VL 45
IS 4
BP 786
EP 795
DI 10.19852/j.cnki.jtcm.2025.04.009 
PG 9
WC Animals; Rabbits; Spondylosis; therapy; Male; Humans; Disease Models, Animal; Acupuncture Therapy; instrumentation; Apoptosis; Tumor Necrosis Factor-alpha; genetics; Neck Muscles; metabolism; Interleukin-6; genetics; Interleukin-1beta; genetics; Electroacupuncture
UT PubMed:40810224
PM 40810224
DA 2025-08-14
ER

PT J
AU Marchant, J
AF Marchant, Jo
TI Acupuncture in cancer study reignites debate about controversial technique.
SO Nature
LA English
DT News
NR 0
TC 0
SN 1476-468
EI 
J9 Nature
PD DEC 15
PY 2017
VL 552
IS 7684
BP 157
EP 158
DI 10.1038/d41586-017-08309-y 
PG 1
WC Acupuncture; Antidepressive Agents; therapeutic use; Aromatase Inhibitors; adverse effects; Breast Neoplasms; complications; Cancer Pain; etiology; Duloxetine Hydrochloride; therapeutic use; Female; Humans; Medication Adherence; psychology; Placebo Effect; Reproducibility of Results
UT PubMed:29239361
PM 29239361
DA 2017-12-15
ER

PT J
AU Kannan, P
   Lam, HY
   Ma, TK
   Lo, CN
   Mui, TY
   Tang, WY
AF Kannan, Priya
   Lam, Hiu Ying
   Ma, Tsz Kiu
   Lo, Chiu Ngai
   Mui, Ting Yan
   Tang, Wing Yan
TI Efficacy of physical therapy interventions on quality of life and upper quadrant 
SO Quality of life research : an international journal of quality of life aspects of 
LA English
DT Journal Article
DE Acupuncture; Decongestive therapy; Exercise; Post-mastectomy pain syndrome; Quality of Life
AB PURPOSE: To determine the efficacy of physical therapy interventions on quality 
   of life (QoL) and pain severity in post-mastectomy pain syndrome (PMPS). METHODS: 
   Multiple databases were searched from database inception to October 2020. 
   Searches were limited to human studies published in either English or Chinese in 
   peer-reviewed journals with full text available for randomized controlled trials 
   conducted on females. Trials comparing the effectiveness of physical therapy 
   interventions against control conditions on QoL and pain were included. RESULTS: 
   Eighteen trials were included in the review. The pooled analysis of the four 
   exercise trials revealed a significant effect of the intervention on general 
   [standardized mean difference [SMD]: 0.87 (95%CI: 0.36, 1.37); p = 0.001], 
   physical [SMD: 0.34 (95%CI: 0.01, 0.66); p = 0.044], and mental health components 
   [SMD: 0.27 (95%CI: 0.03, 0.51); p = 0.027] of QoL compared with the control 
   condition. Meta-analyses of six exercise trials, two myofascial release trials, 
   and two acupuncture trials revealed a significant improvement in pain severity in 
   the treatment group than in the control group. However, meta-analyses of two 
   studies revealed a non-significant effect of compression therapy compared to 
   control on pain severity. CONCLUSION: Our meta-analyses found that exercise is 
   beneficial for improving the QoL and pain severity of women with PMPS. Future 
   studies are needed to determine the optimal parameters for exercise interventions 
   designed to improve QoL and pain severity in women with PMPS. The effect of 
   acupuncture, myofascial release, and compression therapy remains inconclusive, 
   and future research is required to validate the effect of these interventions on 
   PMPS.
C1 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. priya.kannan@polyu.edu.hk.
   Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
   Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
   Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
   Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
   Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
NR 0
TC 0
SN 1573-264
EI 0962-934
J9 Qual Life Res
PD JUN 30
PY 2021
VL 31
IS 4
BP 951
EP 973
DI 10.1007/s11136-021-02926-x 
PG 22
WC Breast Neoplasms; Chronic Pain; Female; Humans; Mastectomy; adverse effects; Pain Measurement; Physical Therapy Modalities; Quality of Life; psychology
UT PubMed:34185226
PM 34185226
DA 2021-06-30
ER

PT J
AU Schencking, M
   Kraft, K
AF Schencking, Martin
   Kraft, Karin
TI [Inpatient treatment for postradical neck pain syndrome by use of complementary 
SO Forschende Komplementarmedizin (2006)
LA ger
DT Journal Article
AB INTRODUCTION: The standard treatment of papillary thyroid cancer with a diameter 
   >1 cm is thyroidectomy combined with a modified neck-dissection of the central 
   (perithyroideal, prelaryngeal and tracheo-esophageal) lymph nodes and a 
   consecutive radiation. Frequently, postoperative pain syndromes occur after this 
   procedure. The so-called 'postradical neck pain syndrome' (PRNS) is a combination 
   of cervical neuropathic pain, constricted and painful mobility of the shoulder 
   region(s) including inhibited abduction capacity of the shoulder joint and a 
   scapula alata. PRNS is often resistant to conventional therapy such as analgesics 
   and physiotherapy. CASE REPORT: A 56-year-old female inpatient, suffering from a 
   severe PRNS after thyroidectomy and neck dissection due to papillary thyroid 
   cancer for the past 2 years, was treated with a combination of hydrotherapy 
   according to Kneipp, conventional physiotherapy, acupuncture and cantharidin 
   blisters in order to reduce neuropathic pain, increase the range of cervical 
   mobility and improve parameters of health-related quality of life (based on 
   SF-36). RESULTS: Within 4 weeks of combined treatment, the left-cervical 
   neuropathic pain was improved remarkably, and the range of the cervical mobility 
   was increased sufficiently. In addition, the SF-36 scales 'pain' and 'common 
   well-being' were improved to a clinically relevant extent. The multi-modular 
   treatment was well tolerated. CONCLUSIONS: In PRNS, a combination of several 
   methods of complementary medicine may be an effective and well tolerated 
   alternative to conventional treatment. Further clinical studies are required to 
   confirm the results.
C1 Kneippsche Kliniken, Bad Wörishofen, Germany. naturedoc@web.de
NR 0
TC 0
SN 1661-412
EI 
J9 Forsch Komplementmed
PD MAY 21
PY 2010
VL 17
IS 2
BP 81
EP 6
DI 10.1159/000287920 
PG -75
WC Acupuncture; Adenocarcinoma, Papillary; surgery; Administration, Cutaneous; Cantharidin; administration & dosage; Chronic Disease; Combined Modality Therapy; Female; Hospitalization; Humans; Hydrotherapy; Middle Aged; Naturopathy; Neck Dissection; Neuralgia; therapy; Pain, Postoperative; therapy; Physical Therapy Modalities; Thyroid Neoplasms; surgery; Thyroidectomy
UT PubMed:20484915
PM 20484915
DA 2010-05-21
ER

PT J
AU Smith, ME
   Bauer-Wu, S
AF Smith, Mary Elizabeth
   Bauer-Wu, Susan
TI Traditional Chinese Medicine for cancer-related symptoms.
SO Seminars in oncology nursing
LA English
DT Review
AB OBJECTIVE: To familiarize oncology nurses about the theory and research related 
   to Traditional Chinese Medicine (TCM) for management of cancer-related symptoms. 
   DATA SOURCES: Peer-reviewed journal articles, TCM texts, professional experience. 
   CONCLUSION: The increasing integration of TCM into mainstream medicine mandates 
   that oncology professionals be familiar with the benefits as well as risks. 
   Clinical research on acupuncture in cancer care is growing and demonstrates it is 
   safe for cancer patients, although results on efficacy across symptoms have been 
   mixed. IMPLICATIONS FOR NURSING PRACTICE: Informed oncology nurses can assist 
   patients by making appropriate referrals to licensed acupuncturists and qualified 
   TCM practitioners to help alleviate unpleasant symptoms associated with cancer 
   and conventional cancer treatment.
C1 Director of Chinese Medicine Services, UNM Center for Life, University of New Mexico, Department of Internal Medicine, Albuquerque, NM 87109, USA.mesmith@salud.unm.edu
NR 0
TC 0
SN 1878-344
EI 
J9 Semin Oncol Nurs
PD JAN 28
PY 2012
VL 28
IS 1
BP 64
EP 74
DI 10.1016/j.soncn.2011.11.007 
PG 10
WC Acupuncture; methods; Adaptation, Psychological; Hot Flashes; Humans; Lymphedema; therapy; Medicine, Chinese Traditional; methods; Nausea; therapy; Neoplasms; complications; Oncology Nursing; methods; Pain; Pain Management; methods; Quality of Life; Referral and Consultation; Stress, Psychological; Tai Ji; Vomiting; therapy; Xerostomia; therapy
UT PubMed:22281311
PM 22281311
DA 2012-01-28
ER

PT J
AU Wanqing, DU
   Liuding, W
   Min, J
   Xiao, L
   Bo, LI
   Yunling, Z
   Xing, L
AF Wanqing, D U
   Liuding, Wang
   Min, Jia
   Xiao, Liang
   Bo, L I
   Yunling, Zhang
   Xing, Liao
TI Mixed methods research in complementary and alternative medicine: a scoping 
SO Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
LA English
DT Journal Article
DE biomedical research; complementary therapies; mixed methods; pilot projects; review
AB OBJECTIVE: To update the current characteristics about the scope and quality of 
   mixed methods research (MMR) in complementary and alternative medicine (CAM) 
   after nearly 10 years. METHODS: A 5-stage approach for conducting a scoping 
   review was adopted. Articles published on the top 10 journals in CAM with the 
   highest impact factor in 2020 were screened for MMR. Information of included 
   articles were extracted, and then synthesized to illustrate the current state. 
   Methodological quality was evaluated according to the Mixed Method Appraisal Tool 
   (MMAT) 2018 version. RESULTS: A total of 55 (55/2991, 2%) articles using mixed 
   methods were retrieved, including 17 medical studies and 38 ethnobotanical 
   studies. We performed an in-depth analysis on the 17 medical studies, which 
   studied cancer, stress, pain, fatigue, exercises, mindfulness intervention, 
   herbal medicine use, art and acupuncture. Thirteen pilot studies applied MMR to 
   evaluate the feasibility of interventions or programs (13/17, 76%); phenomenology 
   was inferred as the most common philosophical assumptions (13/17, 76%); the most 
   applied type of MMR was convergent design (16/17, 94%); integration often took 
   place at integration (12/17, 71%). Among the 16 eligible studies for quality 
   appraisal, majority were rated as good (14/16, 88%), whereas two studies were 
   rated as poorly described. Primarily, a poor rating was due to incomplete 
   reporting of data analysis and citations in qualitative components; lack of 
   confounder controlling and the sampling strategy in quantitative components; poor 
   description of integration and justification for mixed methods. Comparing with 
   the previous review, fewer MMR were published in 2020 in CAM, but the proportion 
   of studies that clearly reported MMR has increased by 4 times (4%→15%). 
   CONCLUSION: CAM researchers need to realize the benefits that MMR can have on 
   conducting further health care research. Our findings highlight that applying MMR 
   will be helpful to understand the complex dynamics and interdisciplinary nature 
   of complex intervention. In addition, addressing a standardized reporting 
   criteria for MMR is recommended.
C1 Department of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
   2 Center for Evidence-based Chinese Medicine, Institute of Basic Research in 
   3 Xiyuan School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
   Department of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
   Department of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
   Department of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
   Department of Clinical Epidemiology, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing Institute of Traditional ChineseMedicine, Beijing 100010, China.
   Department of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
   Center for Evidence-based Chinese Medicine, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700,China.
NR 0
TC 0
SN 2589-451
EI 0255-292
J9 J Tradit Chin Med
PD JUL 19
PY 2022
VL 42
IS 4
BP 652
EP 666
DI 10.19852/j.cnki.jtcm.20220602.002 
PG 14
WC Acupuncture; Acupuncture Therapy; Complementary Therapies; Humans; Phytotherapy; Publications
UT PubMed:35848983
PM 35848983
DA 2022-07-19
ER

PT J
AU Collinge, W
   Kahn, J
   Walton, T
   Kozak, L
   Bauer-Wu, S
   Fletcher, K
   Yarnold, P
   Soltysik, R
AF Collinge, William
   Kahn, Janet
   Walton, Tracy
   Kozak, Leila
   Bauer-Wu, Susan
   Fletcher, Kenneth
   Yarnold, Paul
   Soltysik, Robert
TI Touch, Caring, and Cancer: randomized controlled trial of a multimedia caregiver 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
AB PURPOSE: A randomized controlled trial was conducted to evaluate outcomes of a 
   multimedia instructional program for family caregivers in simple touch-based 
   techniques to provide comfort to cancer patients at home. METHODS: A multilingual 
   78-min DVD and 66-page manual were produced for homebased instruction. Content 
   addresses attitudes and communication about touch in cancer, psychological 
   preparation for giving and receiving touch, safety precautions, massage 
   techniques for comfort and relaxation, acupressure for specific cancer-related 
   symptoms, and practice in the home setting. Materials were produced in English, 
   Spanish, and Chinese versions. A community-based multiethnic sample of 97 adult 
   patient/caregiver dyads was randomized to experimental (massage) or attention 
   control (reading) groups for 4 weeks. Massage dyads received the program and 
   instructions to practice at least three times per week, while control caregivers 
   read to their patients for the same frequency. Self-report instruments assessed 
   change in symptom severity, quality of life, perceived stress, and caregiver 
   attitudes. RESULTS: Significant reductions in all symptoms occurred for patients 
   after both activities: 12-28 % reductions after reading vs. 29-44 % after 
   massage. Massage caregivers showed significant gains in confidence, comfort, and 
   self-efficacy using touch and massage as forms of caregiving. CONCLUSIONS: 
   Multimedia instruction in touch and massage methods may offer family members a 
   viable means of enhancing self-efficacy and satisfaction in caregiving while 
   decreasing patient pain, depression, and other symptoms. Family members may be 
   able to learn and apply safe and simple methods that increase patient comfort and 
   reduce distress.
C1 Collinge and Associates, Eugene, OR 79405, USA. william@collinge.org
NR 0
TC 0
SN 1433-733
EI 0941-435
J9 Support Care Cancer
PD DEC 25
PY 2012
VL 21
IS 5
BP 1405
EP 14
DI 10.1007/s00520-012-1682-6 
PG -1391
WC Adolescent; Adult; Aged; Aged, 80 and over; Attitude to Health; Caregivers; education; Communication; Female; Humans; Male; Massage; education; Middle Aged; Multimedia; Neoplasms; pathology; Outcome Assessment, Health Care; Pain; etiology; Quality of Life; Reading; Self Efficacy; Severity of Illness Index; Stress, Psychological; etiology; Treatment Outcome; Young Adult
UT PubMed:23262808
PM 23262808
DA 2012-12-25
ER

PT J
AU D'Souza, RS
   Alvarez, GAM
   Dombovy-Johnson, M
   Eller, J
   Abd-Elsayed, A
AF D'Souza, Ryan S
   Alvarez, Gabriel A Martinez
   Dombovy-Johnson, Marissa
   Eller, Jennifer
   Abd-Elsayed, Alaa
TI Evidence-Based Treatment of Pain in Chemotherapy-Induced Peripheral Neuropathy.
SO Current pain and headache reports
LA English
DT Journal Article
DE Cancer; Chemotherapy; Chronic pain; Neuromodulation; Peripheral neuropathy; Systematic review
AB PURPOSE OF REVIEW: Chemotherapy-induced peripheral neuropathy (CIPN) is a 
   debilitating and often painful condition that occurs after administration of 
   chemotherapeutic agents. The primary objective of this systematic review was to 
   appraise the literature on conservative, pharmacological, and interventional 
   treatment options for CIPN pain. RECENT FINDINGS: There is level I evidence 
   supporting modest to moderate improvement in CIPN pain from duloxetine treatment, 
   as well as short-term modest improvement from physical therapy and acupuncture. 
   Although opioid and cannabis administration may provide short-term modest 
   improvement, administration is commonly limited by side effects. Generally, most 
   studies reported no clinical benefit from yoga, topical neuropathic agents, 
   gabapentinoids, and tricyclic antidepressants. Evidence is currently equivocal 
   for scrambler therapy and transcutaneous electrical nerve stimulation. Finally, 
   evidence on neuromodulation options is limited to mostly case reports/series and 
   one observational study highlighting moderate improvement with auricular nerve 
   stimulation. This systematic review provides an overview of conservative, 
   pharmacologic, and interventional treatment modalities for CIPN pain. 
   Furthermore, it provides a level of evidence and degree of recommendation based 
   on the United States Preventive Services Task Force (USPSTF) criteria for each 
   specific treatment modality.
C1 Department of Anesthesiology and Perioperative Medicine, Mayo Clinic Hospital, Rochester, MN, USA.
   Department of Physical Medicine and Rehabilitation, Mayo Clinic Hospital, Rochester, MN, USA.
   Department of Physical Medicine and Rehabilitation, Mayo Clinic Hospital, Rochester, MN, USA.
   Department of Anesthesiology and Perioperative Medicine, Mayo Clinic Hospital, Rochester, MN, USA.
   Department of Anesthesiology, University of Wisconsin, Madison, WI, USA. abdelsayed@wisc.edu.
NR 0
TC 0
SN 1534-308
EI 
J9 Curr Pain Headache Rep
PD APR 15
PY 2023
VL 27
IS 5
BP 99
EP 116
DI 10.1007/s11916-023-01107-4 
PG 17
WC Humans; Neuralgia; therapy; Neoplasms; chemically induced; Antineoplastic Agents; adverse effects; Pain Management; Transcutaneous Electric Nerve Stimulation; Observational Studies as Topic
UT PubMed:37058254
PM 37058254
DA 2023-04-15
ER

PT J
AU Akutay, S
   Yüceler, Kaçmaz H
   Ceyhan, Ö
AF Akutay, Seda
   Yüceler Kaçmaz, Hatice
   Ceyhan, Özlem
TI The healing power of transcutaneous electrical nerve stimulation: a systematic 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Breast cancer; Pain; Postoperative care; Transcutaneous electrical nerve stimulation
AB BACKGROUND: Transcutaneous electrical stimulation after breast cancer surgery has 
   been utilized for various purposes, but the full efficacy of this treatment 
   approach on postoperative symptoms remains unclear. AIM: This study aimed to 
   answer the question: Does transcutaneous electrical nerve stimulation 
   significantly impact postoperative patient outcomes in individuals undergoing 
   breast cancer surgery? METHODS: A systematic review of randomized controlled 
   trials was conducted. Because of the limited number of studies included, it was 
   not feasible to perform a meta-analysis. English-language publications from 2013 
   and 2024 that investigated the effects of transcutaneous electrical stimulation 
   in breast cancer surgery patients were included. Electronic databases such as Web 
   of Science, PubMed, Scopus, EBSCO, ScienceDirect, Cochrane Central Register of 
   Controlled Trials, and Wiley Online Library were searched. Two independent 
   investigators assessed the studies using the revised JBI risk of bias tool. Data 
   from randomized trials were extracted by two researchers using the Cochrane data 
   collection tool. RESULTS: Our comprehensive literature review identified 251 
   studies. After rigorous assessment, 12 articles met our inclusion criteria. Title 
   and abstract screening excluded seven studies that did not involve surgery, used 
   treatments other than TENS, included acupuncture, or did not measure pain 
   outcomes. Among these, five studies involving 776 patients examined the effects 
   of transcutaneous electrical stimulation on pain management in breast cancer 
   surgery. In all of the studies reviewed, transcutaneous electrical stimulation 
   had a beneficial effect on postoperative pain. CONCLUSION: Transcutaneous 
   electrical stimulation has significantly alleviated pain associated with breast 
   cancer surgery. This therapeutic modality has improved patient satisfaction with 
   analgesia by relieving pain; reducing analgesic use; reducing postoperative 
   nausea and vomiting; increasing blood levels of IL-2, IFN-γ, and IL-2/IL-4 ratio; 
   and reducing skin sensitivity. Transcutaneous electrical stimulation devices may 
   improve postoperative patient outcomes and enhance the recovery process in people 
   undergoing breast cancer surgery. The results of this study are limited by 
   heterogeneity and the small number of included studies. Future research should 
   prioritize standardization of intervention procedures and investigation of the 
   long-term effects of TENS in postoperative care. REGISTRATION: This study was 
   registered in the PROSPERO registration system under the number CRD42024523558.
C1 Department of Surgical Nursing, Faculty of Health Sciences, Erciyes University, Kayseri, Turkey. sedaakutay@erciyes.edu.tr.
   Department of Surgical Nursing, Faculty of Health Sciences, Erciyes University, Kayseri, Turkey.
   Department of Internal Nursing, Faculty of Health Sciences, Erciyes University, Kayseri, Turkey.
NR 0
TC 0
SN 1433-733
EI 0941-435
J9 Support Care Cancer
PD JAN 13
PY 2025
VL 33
IS 2
BP 90
EP 90
DI 10.1007/s00520-024-09129-3 
PG 0
WC Humans; Transcutaneous Electric Nerve Stimulation; methods; Breast Neoplasms; surgery; Female; Randomized Controlled Trials as Topic; Pain, Postoperative; therapy; Mastectomy
UT PubMed:39804405
PM 39804405
DA 2025-01-13
ER

PT J
AU Zhang, FF
   Zhang, XN
   Zhang, XH
   Nian, FH
   Yuan, B
   Li, F
   Hu, LL
   Li, XJ
   Wang, HD
   DU, XZ
AF Zhang, Feng-Fan
   Zhang, Xiao-Na
   Zhang, Xing-Hua
   Nian, Fang-Hong
   Yuan, Bo
   Li, Fang
   Hu, Le-le
   Li, Xiang-Jun
   Wang, Hai-Dong
   DU, Xiao-Zheng
TI [The effect of heat-reinforcing needling on the level of TRAF6-K63 ubiquitination 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Heat-reinforcing needling; Inflammatory response; Nuclear factor-κB pathway; Rheumatoid arthritis; TRAF6 ubiquitination
AB OBJECTIVES: To observe the effect of heat-reinforcing needling on the level of 
   tumor necrosis factor receptor associated factor 6 (TRAF6)-K63 ubiquitination and 
   the nuclear factor-κB (NF-κB) pathway in the synovial tissue of the knee joints 
   of a rabbit model with rheumatoid arthritis (RA) of cold syndrome, so as to 
   explore the mechanism by which the heat-reinforcing needling inhibits 
   inflammatory response in RA synovitis. METHODS: Eight out of 32 rabbits were 
   randomly selected and assigned to the normal group. The remaining rabbits were 
   induced to establish the RA cold syndrome model using ovalbumin combined with 
   complete Freund's adjuvant and low-temperature cryogenic methods. After modeling 
   evaluation, the rabbits were randomly divided into model group, inhibitor group, 
   and heat-reinforcing needling group, with 6 rabbits in each group. Rabbits in the 
   inhibitor group received intraperitoneal injection of C25-140 solution (2.5 
   mg/kg), twice a day for 14 days. Rabbits in the heat-reinforcing needling group 
   received acupuncture at "Zusanli"(ST36) according to the operation standard of 
   the heat-reinforcing needling and the needle was retained for 30 min, once a day, 
   for 14 days. After the intervention, knee joint circumference and pain threshold 
   of the rabbits were measured. Color Doppler ultrasound was used to observe 
   changes in knee joint imaging. HE staining was performed to observe morphological 
   changes in the synovial tissue. Immunohistochemical method was used to observe 
   the expression of inflammatory factors tumor necrosis factor (TNF)-α, interleukin 
   (IL)-1β, and IL-6 in the synovial tissue. Western blot was used to detect the 
   protein expression of ubiquitin-conjugating enzyme E2 13 (Ubc13) and NF-κB p65 in 
   the synovial tissue, and co-immunoprecipitation was used to detect the level of 
   TRAF6-K63 ubiquitination in the synovial tissue. RESULTS: Compared with the 
   normal group, the model group showed a decreased pain threshold (P<0.05), 
   increased knee joint circumference (P<0.05), and increased average optical 
   density of TNF-α, IL-1β, and IL-6 in the synovial tissue(P<0.05), as well as 
   elevated protein expression of NF-κB p65 and TRAF6-K63 ubiquitination levels 
   (P<0.05), while Ubc13 protein expression was decreased (P<0.05). Compared with 
   the model group, the heat-reinforcing needling group and the inhibitor group had 
   increased pain thresholds and reduced knee joint circumferences (P<0.05), and 
   significantly reduced average optical density of TNF-α, IL-1β, and IL-6 in the 
   synovial tissue (P<0.05), as well as decreased protein expression of NF-κB p65, 
   TRAF6-K63 ubiquitination levels (P<0.05), while Ubc13 protein expression was 
   increased (P<0.05). Compared to the heat-reinforcing needling group, the 
   inhibitor group showed reduced pain threshold (P<0.05), and lower average optical 
   density values of TNF-α, IL-1β, IL-6 in the synovial tissue (P<0.05), as well as 
   decreased expression of NF-κB p65 protein, TRAF6-K63 ubiquitination levels 
   (P<0.05), while Ubc13 protein expression was increased (P<0.05). The imaging 
   changes of the knee joints and the pathological morphological changes of the 
   synovial tissues in the two treatment groups are both less severe than those in 
   the model group. CONCLUSIONS: The heat-reinforcing needling may inhibit 
   inflammatory response in synovitis by suppressing TRAF6-K63 ubiquitination 
   levels, down-regulating the activity of the NF-κB pathway, and reducing the 
   secretion of downstream inflammatory factors.
C1 Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China.
   Jining Hospital of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Jining 272000, Shandong Province.
   Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China.
   Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China.
   Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000.
   Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China.
   Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China.
   Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China.
   Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China.
   Gansu University of Chinese Medicine, Lanzhou 730000. lz-duxiaozheng@163.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUN 24
PY 2025
VL 50
IS 6
BP 641
EP 648
DI 10.13702/j.1000-0607.20240329 
PG 7
WC Animals; Rabbits; Arthritis, Rheumatoid; therapy; Knee Joint; metabolism; Acupuncture Therapy; NF-kappa B; genetics; Synovial Membrane; metabolism; Ubiquitination; Humans; TNF Receptor-Associated Factor 6; genetics; Male; Acupuncture Points; Female; Signal Transduction
UT PubMed:40551646
PM 40551646
DA 2025-06-24
ER

PT J
AU Cheng, J
   Hu, S
   Fang, Y
   Cao, G
   Jiang, T
   Wang, Y
AF Cheng, Jing
   Hu, Shiyi
   Fang, Yuru
   Cao, Guixia
   Jiang, Tao
   Wang, Yiqiao
TI [Effect of perioperative transcutaneous electrical acupoint stimulation on 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE elderly patients; inflammatory response; laparoscopic radical gastrectomy; oxidative stress; pain; postoperative fatigue syndrome; transcutaneous electrical acupoint stimulation
AB OBJECTIVE: To observe the effect of perioperative transcutaneous electrical 
   acupoint stimulation (TEAS) on postoperative fatigue syndrome (POFS) in elderly 
   patients undergoing laparoscopic radical gastrectomy. METHODS: A total of 80 
   elderly patients scheduled for laparoscopic radical gastrectomy were randomized 
   into a TEAS group and a sham TEAS group, 40 cases in each one. In the TEAS group, 
   TEAS intervention was applied at bilateral Hegu (LI4), Neiguan (PC6), Zusanli 
   (ST36) and Sanyinjiao (SP6) from 30 min before anesthesia induction until surgery 
   completion, and at 18:00 on 1st, 2nd and 3rd days after surgery, once a day, 30 
   min a time. In the sham TEAS group, the same acupoints were selected and 
   connected to the electroacupuncture device at the same time, without electrical 
   stimulation. One day before surgery and 1, 3, 7 days after surgery, the 10-item 
   short form of identity consequence fatigue scale (ICFS-10) score was observed, 
   and the POFS incidence rate of 1, 3, 7 days after surgery was assessed in the two 
   groups. One day before surgery, surgery completion, and 1, 3 days after surgery, 
   the serum levels of superoxide dismutase (SOD), β-endorphin (β-EP) were detected; 
   1 day before surgery and 1, 3, 7 days after surgery, the serum level of tumor 
   necrosis factor-α (TNF-α) was detected in the two groups. The pain visual analog 
   scale (VAS) score was observed at 24, 48 and 72 h after surgery; the 
   intraoperative dosage of propofol and remifentanil, and the incidence rate of 
   postoperative nausea and vomiting, itching, respiratory depression were recorded 
   in the two groups. RESULTS: In the TEAS group, on 1, 3, 7 days after surgery, 
   except for the scores of item 8-10, the item scores and the total scores of 
   ICFS-10 were lower than those in the sham TEAS group (P<0.001); on 3 and 7 days 
   after surgery, the POFS incidence rates were lower than those in the sham TEAS 
   group (P<0.05). In the TEAS group, on 1 and 3 days after surgery, the serum 
   levels of SOD were higher than those in the sham TEAS group (P<0.05, P<0.01); at 
   surgery completion, and on 1, 3 days after surgery, the serum levels of β-EP were 
   higher than those in the sham TEAS group (P<0.001, P<0.01); on 1, 3, 7 days after 
   surgery, the serum levels of TNF-α were lower than those in the sham TEAS group 
   (P<0.01, P<0.001). In the TEAS group, at 24, 48 and 72 h after surgery, the pain 
   VAS scores were lower than those in the sham TEAS group (P<0.001, P<0.01, 
   P<0.05); the intraoperative dosage of remifentanil was lower than that in the 
   sham TEAS group (P<0.001); the incidence rate of postoperative nausea and 
   vomiting was lower than that in the sham TEAS group (P<0.01). CONCLUSION: 
   Perioperative TEAS intervention can effectively reduce the incidence rate of 
   POFS, improve fatigue symptom and mental state in elderly patients undergoing 
   laparoscopic radical gastrectomy, its mechanism may related to enhancing 
   endogenous β-EP release, inhibiting inflammatory response, and reducing central 
   oxidative stress, thereby promoting postoperative recovery.
C1 Graduate School, Bengbu Medical University, Bengbu 233030, Anhui Province, China.
   Graduate School, Bengbu Medical University, Bengbu 233030, Anhui Province, China.
   Graduate School, Bengbu Medical University, Bengbu 233030, Anhui Province, China.
   Department of Anesthesiology, Anhui No.2 Provincial People's Hospital, Hefei 230041.
   Department of Anesthesiology, Anhui No.2 Provincial People's Hospital, Hefei 230041.
   Graduate School, Bengbu Medical University, Bengbu 233030, Anhui Province, China
   Department of Anesthesiology, Anhui No.2 Provincial People's Hospital, Hefei230041.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD AUG 19
PY 2025
VL 45
IS 8
BP 1071
EP 1077
DI 10.13703/j.0255-2930.20240814-k0004 
PG 6
WC Humans; Acupuncture Points; Male; Female; Aged; Transcutaneous Electric Nerve Stimulation; Postoperative Complications; therapy; Middle Aged; Fatigue; therapy; Gastrectomy; adverse effects; beta-Endorphin; blood; Tumor Necrosis Factor-alpha; blood
UT PubMed:40825690
PM 40825690
DA 2025-08-19
ER

PT J
AU Chen, C
   Wang, Y
AF Chen, Chuihai
   Wang, Yujie
TI [Penetrating needling of three eye acupoints combined with sodium hyaluronate eye 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture; dry eye; penetrating needling; randomized controlled trial (RCT); sodium hyaluronate eye drops; three eye acupoints
AB OBJECTIVE: To compare the clinical efficacy between penetrating needling of three 
   eye acupoints combined with sodium hyaluronate eye drops and sodium hyaluronate 
   eye drops alone for the treatment of dry eye. METHODS: A total of 156 patients 
   (312 eyes) with dry eye were randomly assigned to an observation group and a 
   control group, with 78 patients (156 eyes) in each group. The control group was 
   treated with sodium hyaluronate eye drops, one drop per eye, four times daily, 
   for 4 weeks. In addition to the sodium hyaluronate treatment, the observation 
   group received penetrating needling of three eye acupoints. Acupoints included 
   bilateral Cuanzhu (BL2), Sizhukong (TE23), Sibai (ST2), and Jingming (BL1). 
   Needling was performed once daily, four times a week, for 4 weeks. The subjective 
   ocular symptom scores, neuropathic pain symptom inventory-eye (NPSI-Eye) scores, 
   ocular surface disease index (OSDI) scores, corneal fluorescein staining (FL) 
   scores, tear break-up time (BUT), SchirmerⅠtest (SⅠT), central tear meniscus 
   height (TMH), and tear levels of interleukin-6 (IL-6) and tumor necrosis 
   factor-alpha (TNF-α) were evaluated before and after treatment in the two groups. 
   Clinical efficacy was also compared between the two groups. RESULTS: After 
   treatment, both groups showed significant improvements in subjective ocular 
   symptom scores, NPSI-Eye scores, OSDI scores, FL scores, and reductions in tear 
   IL-6 and TNF-α levels (P<0.01). Additionally, BUT, SⅠT, and TMH were increased 
   significantly in both groups (P<0.01). After treatment, the subjective ocular 
   symptom scores, NPSI-Eye score, OSDI score, FL score, and tear levels of IL-6 and 
   TNF-α in the observation group were lower than those in the control group 
   (P<0.01, P<0.05), while BUT, SⅠT, and TMH were significantly improved compared to 
   the control group (P<0.01). The markedly effective rate and total effective rate 
   in the observation group were 83.3% (65/78) and 100.0% (78/78), respectively, 
   which were higher than 52.6% (41/78, P<0.01) and 92.3% (72/78, P<0.05) in the 
   control group. CONCLUSION: The penetrating needling of three eye acupoints 
   combined with sodium hyaluronate eye drops can effectively alleviate symptoms of 
   dry eye, reduce inflammatory response, and has superior efficacy to sodium 
   hyaluronate eye drops alone.
C1 Ophthalmology Department, Bao'an District TCM Hospital, Shenzhen 518133, Guangdong Province, China.
   Pediatric Neurological Rehabilitation Department, Shenzhen Maternity and Child Healthcare Hospital.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAY 15
PY 2025
VL 45
IS 5
BP 633
EP 637
DI 10.13703/j.0255-2930.20240521-0002 
PG 4
WC Humans; Hyaluronic Acid; administration & dosage; Male; Female; Dry Eye Syndromes; therapy; Middle Aged; Acupuncture Points; Ophthalmic Solutions; administration & dosage; Adult; Aged; Treatment Outcome; Acupuncture Therapy; Interleukin-6; metabolism; Young Adult; Tumor Necrosis Factor-alpha; metabolism
UT PubMed:40369920
PM 40369920
DA 2025-05-15
ER

PT J
AU Choi, HS
   Lee, YJ
   Hahm, DH
   Lee, H
   Ha, IH
AF Choi, Hee-Seung
   Lee, Yoon Jae
   Hahm, Dae-Hyun
   Lee, Hyangsook
   Ha, In-Hyuk
TI The effect of integrative Korean medicine treatment on symptomatic lumbar facet 
SO Explore (New York, N.Y.)
LA English
DT Journal Article
DE Facet joint cyst; Integrative Korean medicine treatment; Lumbar; Zygapophyseal joint
AB OBJECTIVE: The optimal treatment for facet joint cysts (FJCs) has remained 
   controversial. Despite a higher success rate than the conservative option, 
   surgical treatments may pose risks of postoperative complications and 
   comorbidities may make the surgical approach difficult. Thus, this study reports 
   four cases of pain amelioration and resorption of FJCs through noninvasive 
   integrative Korean Medicine treatment. METHODS: For intervention, four patients 
   with symptomatic FJCs underwent integrative Korean medicine treatment with 
   acupuncture, herbal medicine, pharmacopuncture, and Chuna manual therapy; after 
   completion of the series of treatment sessions, patients were re-examined with 
   magnetic resonance imaging (MRI). RESULTS: Pain disappeared within 2 months for 
   all four patients; the amelioration of pain was sustained for more than 6 months. 
   Furthermore, the disappearance of FJCs was confirmed by MRI after a certain 
   period from the time of pain disappearance. CONCLUSIONS: This study reported the 
   effectiveness of non-invasive, integrative Korean medicine treatment for patients 
   with FJCs; this method shows promise as a conservative treatment option for 
   patients with FJCs.
C1 Jaseng Hospital of Korean Medicine, Republic of Korea
   Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University,Republic of Korea.
   Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Republic of Korea.
   Department of Physiology, College of Medicine, Kyung Hee University, Republic of Korea.
   Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Republic of Korea.
   Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Republic of Korea. 
EM hanihata@gmail.com
NR 0
TC 0
SN 1878-754
EI 
J9 Explore (NY)
PD JUN 24
PY 2023
VL 20
IS 1
BP 130
EP 137
DI 10.1016/j.explore.2023.06.003 
PG 7
WC Humans; Zygapophyseal Joint; diagnostic imaging; Low Back Pain; drug therapy; Lumbar Vertebrae; diagnostic imaging; Cysts; complications; Republic of Korea
UT PubMed:37353459
PM 37353459
DA 2023-06-24
ER

PT J
AU Pugh, SL
   Wyatt, G
   Wong, RK
   Sagar, SM
   Yueh, B
   Singh, AK
   Yao, M
   Nguyen-Tan, PF
   Yom, SS
   Cardinale, FS
   Sultanem, K
   Hodson, DI
   Krempl, GA
   Chavez, A
   Yeh, AM
   Bruner, DW
AF Pugh, Stephanie L
   Wyatt, Gwen
   Wong, Raimond K W
   Sagar, Stephen M
   Yueh, Bevan
   Singh, Anurag K
   Yao, Min
   Nguyen-Tan, Phuc Felix
   Yom, Sue S
   Cardinale, Francis S
   Sultanem, Khalil
   Hodson, D Ian
   Krempl, Greg A
   Chavez, Ariel
   Yeh, Alexander M
   Bruner, Deborah W
TI Exploratory Factor Analysis of NRG Oncology's University of Washington Quality of 
SO Journal of pain and symptom management
LA English
DT Journal Article
DE Quality of life; factor analysis; xerostomia
AB CONTEXT: The 15-item University of Washington Quality of Life 
   questionnaire-Radiation Therapy Oncology Group (RTOG) modification (UW-QOL-RTOG 
   modification) has been used in several trials of head and neck cancer conducted 
   by NRG Oncology such as RTOG 9709, RTOG 9901, RTOG 0244, and RTOG 0537. 
   OBJECTIVES: This study is an exploratory factor analysis (EFA) to establish 
   validity and reliability of the instrument subscales. METHODS: EFA on the 
   UW-QOL-RTOG modification was conducted using baseline data from NRG Oncology's 
   RTOG 0537, a trial of acupuncture-like transcutaneous electrical nerve 
   stimulation in treating radiation-induced xerostomia. Cronbach α coefficient was 
   calculated to measure reliability; correlation with the University of Michigan 
   Xerostomia Related Quality of Life Scale was used to evaluate concurrent 
   validity; and correlations between consecutive time points were used to assess 
   test-retest reliability. RESULTS: The 15-item EFA of the modified tool resulted 
   in 11 items split into four factors: mucus, eating, pain, and activities. 
   Cronbach α ranged from 0.71 to 0.93 for the factors and total score, consisting 
   of all 11 items. There were strong correlations (ρ ≥ 0.60) between consecutive 
   time points and between total score and the Xerostomia Related Quality of Life 
   Scale total score (ρ > 0.65). CONCLUSION: The UW-QOL-RTOG modification is a valid 
   tool that can be used to assess symptom burden of head and neck cancer patients 
   receiving radiation therapy or those who have recently completed radiation. The 
   modified tool has acceptable reliability, concurrent validity, and test-retest 
   reliability in this patient population, as well as the advantage of having being 
   shortened from 15 to 11 items.
C1 NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania, USA. 
   Michigan State University, East Lansing, Michigan, USA.
   Juravinski Cancer Centre, McMaster University, Hamilton, Ontario, Canada.
   Juravinski Cancer Centre, McMaster University, Hamilton, Ontario, Canada.
   University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota, USA.
   Roswell Park Cancer Institute, Buffalo, New York, USA.
   Case Western Reserve University, Cleveland, Ohio, USA.
   CHUM-Hôpital Notre-Dame, Montréal, Quebec, Canada.
   UCSF Medical Center, San Francisco, California, USA.
   Yale University, New Haven, Connecticut, USA.
   McGill University, Montréal, Quebec, Canada.
   Juravinski Cancer Centre, McMaster University, Hamilton, Ontario, Canada.
   University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
   John H. Stroger Jr. Hospital of Cook County, Chicago, Illinois, USA.
   Indiana University Hospital/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, USA.
   Emory University/Winship Cancer Institute, Atlanta, Georgia, USA.
EM pughs@nrgoncology.org
NR 0
TC 0
SN 1873-651
EI 0885-392
J9 J Pain Symptom Manage
PD DEC 3
PY 2016
VL 53
IS 1
BP 139
EP 145.e2
DI 10.1016/j.jpainsymman.2016.11.002 
PG 1
WC Activities of Daily Living; psychology; Aged; Eating; psychology; Factor Analysis, Statistical; Female; Head and Neck Neoplasms; complications; Humans; Male; Middle Aged; Pain; etiology; Quality of Life; psychology; Surveys and Questionnaires
UT PubMed:27899312
PM 27899312
DA 2016-12-03
ER

PT J
AU Wang, HD
   Wang, HY
   Yang, LY
   Liu, JJ
   Zhang, T
   Zheng, J
AF Wang, Huang-Dong
   Wang, Hua-Yu
   Yang, Li-Yue
   Liu, Ji-Jun
   Zhang, Tao
   Zheng, Jia
TI [Acupotomy at trigger points combined with meridian sinew manipulation in 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Acupotomy; Clinical efficacy; Inflammatory response; Knee osteoarthritis; Randomized controlled trial; Trigger point
AB OBJECTIVES: To observe the clinical efficacy of acupotomy at trigger points 
   combined with meridian sinew manipulation in treatment of early and mid-term knee 
   osteoarthritis (KOA), and investigate whether its therapeutic mechanism is 
   related to the regulation of inflammatory response. METHODS: Seventy-four 
   patients with early and mid-term KOA were randomly divided into the control group 
   (37 cases, with 2 cases dropouts) and the observation group (37 cases, with 1 
   case dropout). The control group was treated with meridian sinew manipulation for 
   30 min each time, 5 times a week, for 4 consecutive weeks. The observation group 
   was given acupotomy at trigger points on the basis of the treatment of control 
   group, once a week, for 4 consecutive weeks. Western Ontario and McMaster 
   University osteoarthritis index (WOMAC) scores, short-form McGill pain 
   questionnaire (SF-MPQ) scores, the medical outcome 36-item short form health 
   survey (SF-36) scores, serum inflammatory factors content before and after 
   treatment were compared between the two groups. The clinical efficacy were 
   assessed after the treatment. RESULTS: Compared with those before treatment, the 
   total scores and the scores of pain, stiffness and activity impairment of WOMAC, 
   the pain rating index (PRI), visual analog scale (VAS) and present pain intensity 
   (PPI) scores of SF-MPQ, and the contents of serum tumor necrosis factor (TNF)-α, 
   interleukin (IL)-6 and IL-10 in both groups were significantly decreased after 
   treatment (P<0.05), while the scores of the physical component summary (PCS) and 
   the mental component summary (MCS) of SF-36 were significantly increased 
   (P<0.05). Compared with the control group, the total scores, scores of pain, 
   stiffness and activity impairment of WOMAC, the PRI, VAS and PPI scores of 
   SF-MPQ, and the contents of serum TNF-α, IL-6 and IL-10 in the observation group 
   were significantly decreased after treatment (P<0.05), while the scores of PCS 
   and MCS of SF-36 were significantly increased (P<0.05). The total effective rate 
   of the observation group was 94.4% (34/36) after treatment, which was 
   significantly higher than that of the control group (74.3%, 26/35, P<0.05). 
   CONCLUSIONS: Acupotomy at trigger points combined with meridian sinew 
   manipulation can significantly improve the clinical symptoms such as joint pain, 
   stiffness and limited activity in patients with KOA, improve the quality of life, 
   and its mechanism may be related to reducing the inflammatory response.
C1 Graduate School, Anhui University of Chinese Medicine, Hefei 230012, China.
   The Department of Joint and Bone, Lu'an Hospital of Traditional Chinese Medicine, 
   The Department of Joint and Bone, Lu'an Hospital of Traditional Chinese Medicine, Lu'an 237000, Anhui Province. why2834463@163.com.
   The 2rd Department of Joint and Bone, Wuhu Hospital of Traditional Chinese Medicine, Wuhu 241000, Anhui Province.
   Graduate School, Anhui University of Chinese Medicine, Hefei 230012, China.
   Graduate School, Anhui University of Chinese Medicine, Hefei 230012, China.
   Graduate School, Anhui University of Chinese Medicine, Hefei 230012, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUL 22
PY 2025
VL 50
IS 7
BP 822
EP 828
DI 10.13702/j.1000-0607.20240549 
PG 6
WC Humans; Osteoarthritis, Knee; therapy; Female; Male; Middle Aged; Aged; Acupuncture Therapy; Acupuncture Points; Meridians; Treatment Outcome; Interleukin-6; blood; Tumor Necrosis Factor-alpha; blood; Interleukin-10; blood; Adult
UT PubMed:40691033
PM 40691033
DA 2025-07-22
ER

PT J
AU Kristoffersen, AE
   Wider, B
   Nilsen, JV
   Bjelland, M
   Mora, DC
   Nordberg, JH
   Broderstad, AR
   Nakandi, K
   Stub, T
AF Kristoffersen, Agnete E
   Wider, Barbara
   Nilsen, Jorunn V
   Bjelland, Mona
   Mora, Dana C
   Nordberg, Johanna Hök
   Broderstad, Ann Ragnhild
   Nakandi, Kiwumulo
   Stub, Trine
TI Prevalence of late and long-term effects of cancer (treatment) and use of 
SO BMC complementary medicine and therapies
LA English
DT Journal Article
DE CAM; Cancer; Complementary therapies; Late effects; Long-term effects; Supportive care
AB BACKGROUND: The increasing number of patients surviving cancer leads to more 
   people experiencing late and long term-effects from the disease and its 
   treatment. Fatigue, sleep disorders, early menopause, pain, and nerve damage are 
   commonly reported. Methods helping people to recover after cancer treatment are 
   therefore essential. The aims of this study were threefold; (1) to determine the 
   level of cancer patients suffering from late and long-term effects of cancer 
   diagnosis and treatment in Norway, (2) explore complementary and alternative 
   medicine (CAM) modalities used for managing these adversities, and (3) describe 
   self-perceived benefits and harms of the CAM interventions. METHODS: The study 
   was conducted in cooperation with the Norwegian Cancer Society (NCS) and 
   consisted of an online cross-sectional study among members of the NCS user panel 
   with present or previous cancer (n = 706). The study was carried out in 
   September/October 2021 using a modified cancer-specific version of the 
   International Questionnaire to Measure Use of Complementary and Alternative 
   Medicine (I-CAM-Q). A total of 315 women and 153 men agreed to participate, 
   resulting in a response rate of 67%. RESULTS: Most of the participants (83%) 
   suffered from late and long-term effects of cancer treatment; mostly fatigue 
   (59.2%), sleep disorder (41.5%), hot flashes (39.2%), nerve damage 
   (polyneuropathy, 38.0%), and pain (36.6%) with a mean number of 5.1 different 
   late and long-term effects. Late and long-term effects were positively associated 
   with younger age and college/university education. Nearly half of the 
   participants experiencing late and long-term effects (43%) reported having used 
   CAM to treat these complaints. Most frequently used were self-help practices 
   (26%) such as relaxation therapy (19%), yoga (14%) and meditation (13%), but also 
   visits to CAM providers were reported by 22%. Herbal- and other natural remedies 
   to treat late and long-term effects were used by 13%. A high percentage of CAM 
   users reported self-perceived improvements of their symptoms (86% for self-help 
   practices, 90% for visits to CAM providers). Few experienced adverse effects of 
   the CAM treatment. CONCLUSION: A large proportion of cancer patients suffered 
   from a wide range of late and long-term effects of cancer diagnosis and 
   treatment, and they use CAM to treat these complaints to a rather high degree. 
   Relaxation therapy, yoga, meditation, massage, and acupuncture were the most 
   frequently used therapies regardless of complaint. The therapies used are 
   generally considered to be both safe and beneficial for the respective complaint, 
   indicating that the participants seem to be well informed about the choices they 
   make.
C1 National Research Center in Complementary and Alternative Medicine (NAFKAM), Department of Community Medicine, UiT The Arctic University of Norway, Tromsø,Norway. agnete.kristoffersen@uit.no.
   National Research Center in Complementary and Alternative Medicine (NAFKAM), Department of Community Medicine, UiT The Arctic University of Norway, Tromsø,Norway.
   The Norwegian Cancer Society, Oslo, Norway.
   The Norwegian Cancer Society, Oslo, Norway.
   National Research Center in Complementary and Alternative Medicine (NAFKAM), Department of Community Medicine, UiT The Arctic University of Norway, Tromsø,Norway.
   Regional Cancer Center Stockholm Gotland, Stockholm, Sweden.
   Karolinska Institutet, Department of Neurobiology, Care Sciences & Society, 
   Centre for Sami Health Research, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
   National Research Center in Complementary and Alternative Medicine (NAFKAM), Department of Community Medicine, UiT The Arctic University of Norway, Tromsø,Norway.
   National Research Center in Complementary and Alternative Medicine (NAFKAM), Department of Community Medicine, UiT The Arctic University of Norway, Tromsø,Norway.
NR 0
TC 0
SN 2662-767
EI 
J9 BMC Complement Med Ther
PD DEC 6
PY 2022
VL 22
IS 1
BP 322
EP 322
DI 10.1186/s12906-022-03790-z 
PG 0
WC Male; Humans; Female; Prevalence; Cross-Sectional Studies; Complementary Therapies; Neoplasms; therapy; Pain; Fatigue; therapy
UT PubMed:36471296
PM 36471296
DA 2022-12-06
ER

PT J
AU Cao, X
   Wu, G
   Jiao, B
   Zhang, X
AF Cao, Xueqin
   Wu, Gang
   Jiao, Bo
   Zhang, Xianwei
TI Refractory postherpetic neuralgia in a multiple myeloma patient with lenalidomide 
SO The Journal of international medical research
LA English
DT Journal Article
DE Postherpetic neuralgia; chemotherapy-induced periphery neuropathy; herpes zoster; lenalidomide; multiple myeloma; pain
AB Herpes zoster is not common in multiple myeloma (MM) patients treated with 
   lenalidomide-based regimens. We report an MM patient in his late 60s who received 
   lenalidomide as maintenance treatment and whose condition was complicated with 
   refractory postherpetic neuralgia. The patient received antiviral treatment and 
   analgesia immediately after the diagnosis of herpes zoster. Two months later, the 
   patient received acupuncture, radiofrequency treatment, and even spinal cord 
   stimulation, which failed to relieve the pain. Consequently, we performed 
   high-resolution magnetic resonance imaging of the cervical and thoracic nerves. 
   Then, stellate ganglion block, left C5/C6/C7/C8 nerve root block, and left 
   thoracic 1, 2 paravertebral nerve block were performed with the assistance of 
   real-time ultrasound. The pain was immediately relieved after treatment; however, 
   the symptoms reappeared 2 days later. At 5 months after treatment, the patient 
   still experienced severe pain. We suggest that MM patients complicated with 
   postherpetic neuralgia are refractory to treatment. Starting nerve block therapy, 
   pulsed radiofrequency, and other interventional therapies as early as possible 
   could be a more optimal treatment plan for these patients.
C1 Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
   Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
   Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
   Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
NR 0
TC 0
SN 1473-230
EI 0300-060
J9 J Int Med Res
PD SEP 30
PY 2022
VL 50
IS 9
BP 3000605221123882
EP 3000605221123882
DI 10.1177/03000605221123882 
PG 1
WC Antiviral Agents; therapeutic use; Herpes Zoster; complications; Humans; Lenalidomide; therapeutic use; Multiple Myeloma; complications; Neuralgia, Postherpetic; complications
UT PubMed:36171724
PM 36171724
DA 2022-09-30
ER

PT J
AU Ma, M
   Zhang, L
   Wang, X
AF Ma, Mengjie
   Zhang, Liuqiao
   Wang, Xiangli
TI Effect of auricular point pressing therapy on hyperplasia of mammary glands: A 
SO Medicine
LA English
DT Journal Article
AB BACKGROUND: In recent years, with the accelerated pace of life, diet, 
   environmental problems occur frequently. External factors are easily to cause 
   endocrine disorders and hormone sensitivity of breast tissue, which can lead to 
   mammary hyperplasia. The incidence rate of hyperplasia of mammary glands is 
   increasing year by year, and the age of onset is also getting lower and lower. If 
   not treated in time, there is a crisis of breast cancer.Clinical studies have 
   found that auricular point pressing therapy is widely used in clinical treatment 
   of mammary hyperplasia recently, but the efficacy of massage in the treatment of 
   mammary hyperplasia has not been systematically reviewed. The purpose of this 
   study is to explore the efficacy, safety and effectiveness of auricular point 
   pressing therapy in the treatment of hyperplasia of mammary glands. METHODS: We 
   will search PubMed, Web of Science, Cochrane Library, EMBASE, Wan fang Database, 
   Chinese Scientific Journal Database, CNKI, VIP, and Chinese Biomedical Literature 
   Database. The retrieval date was January 10, 2021. RevMan 5.3 software was used 
   to evaluate the quality and risk of included studies. The efficacy, recurrence 
   rate, and symptom score of breast hyperplasia were analyzed, and the results were 
   observed and measured. RESULTS: This study will be from the clinical efficiency, 
   improvement rate, pain symptoms disappear rate, tumor size improvement rate, and 
   other aspects of the existing evidence for a high quality synthesis, as well as 
   auricular point pressing therapy adverse events. CONCLUSION: the conclusion of 
   this review will provide the basis for judging whether auricular point pressing 
   therapy is safe and effective in the treatment of hyperplasia of mammary glands. 
   ETHICS AND DISSEMINATION: This systematic will evaluate the effectiveness and 
   safety of auricular point pressing therapy in the treatment of hyperplasia of 
   mammary glands. As all data used in this systematic review and meta-analysis have 
   been published, ethical approval is not required for this review. PROTOCOL 
   REGISTRATION NUMBER: INPLASY202110028.
C1 Henan University of Traditional Chinese Medicine, 156 Jinshui East Road, Zhengdong New District, Zhengzhou City, Henan Province, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD APR 1
PY 2021
VL 100
IS 13
BP e24875
EP e24875
DI 10.1097/MD.0000000000024875 
PG 1
WC Acupuncture Points; Breast Diseases; pathology; Clinical Trials as Topic; Ear Auricle; Female; Humans; Hyperplasia; therapy; Mammary Glands, Human; pathology; Massage; methods; Meta-Analysis as Topic; Research Design; Systematic Reviews as Topic; Treatment Outcome
UT PubMed:33787577
PM 33787577
DA 2021-04-01
ER

PT J
AU Nagykálnai, T
   Landherr, L
   Mészáros, E
AF Nagykálnai, Tamás
   Landherr, László
   Mészáros, Edina
TI [Aromatase inhibitors and arthralgia].
SO Magyar onkologia
LA hun
DT Review
AB In several large adjuvant clinical trials it has been demonstrated that 
   substitution (eventually addition) of aromatase inhibitors (AIs) provides an 
   improved outcome of endocrine-sensitive breast cancer over tamoxifen alone. 
   Nevertheless, arthralgia induced by the AIs is one of the most frequent side 
   effects in hormonal therapy. It is characterized by tenosynovial changes and is 
   more frequent in patients in clinical practice than previously appreciated in 
   adjuvant clinical trials. AI-related arthralgia may be related to estrogen 
   deprivation, but estrogen replacement is not an option for these women. Therefore 
   standard painkillers, NSAIDs (COX2 inhibitors), week opioids and other 
   interventions (vitamin D, calcium, bisphosphonates, exercise, acupuncture, 
   complementary and alternative approaches, eventually switch to another endocrine 
   drug) are used for managing this treatment-related side effect, and improve 
   adherence and quality of life among breast cancer survivors.
C1 Budapest XV. ker. Onkológiai Gondozó, Budapest. nagykalnai.tamas@t-online.hu
NR 0
TC 0
SN 
EI 0025-024
J9 Magy Onkol
PD MAY 28
PY 2011
VL 55
IS 1
BP 32
EP 9
DI 
PG -23
WC Anastrozole; Androstadienes; adverse effects; Antineoplastic Agents, Hormonal; administration & dosage; Aromatase Inhibitors; administration & dosage; Arthralgia; chemically induced; Breast Neoplasms; drug therapy; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Medication Adherence; Neoplasms, Hormone-Dependent; drug therapy; Nitriles; adverse effects; Postmenopause; Quality of Life; Risk Factors; Triazoles; adverse effects
UT PubMed:21617789
PM 21617789
DA 2011-05-28
ER

PT J
AU Sung, SH
   Kim, JW
   Han, JE
   Shin, BC
   Park, JK
   Lee, G
AF Sung, Soo-Hyun
   Kim, Ji-Won
   Han, Ji-Eun
   Shin, Byung-Cheul
   Park, Jang-Kyung
   Lee, Gihyun
TI Animal Venom for Medical Usage in Pharmacopuncture in Korean Medicine: Current 
SO Toxins
LA English
DT Review
DE animal venom; bee venom; pharmacopuncture; snake venom; toad venom
AB Animal venoms, widespread throughout the world, are complex mixtures, the 
   composition of which depends on the venom-producing species. The objective of 
   this study was to contribute to the development of animal venom-based medicines 
   by investigating the use of animal venom pharmacopuncture in Korean medicine (KM) 
   institutions. We surveyed 256 public health centers from 1 through 31 October 
   2019 as guided by the Ministry of Health and Welfare (MoHW). A questionnaire 
   developed by an expert group was distributed and collected for statistical 
   analysis. The survey identified three types of animal venom-based 
   pharmacopuncture: bee, snake, and toad venoms. The medications are based on a 
   single animal venom ingredient and produced in 11 external herbal dispensaries 
   (EHDs). Each animal venom is processed, refined, and freeze-dried in a cleanroom 
   to produce a powder formulation that is later measured, diluted, filtered, 
   filled, sealed, sterilized, and packaged as pharmacopuncture injections used in 
   KM institutions. Bee venom therapy is effective in treating musculoskeletal pain, 
   snake venom therapy is effective in controlling bleeding during surgery, and toad 
   venom therapy is effective in cancer treatment. The study suggests that bee, 
   snake, and toad venoms could be used in medical institutions and have the 
   potential for drug development.
C1 Department of Policy Development, National Development Institute of Korean Medicine, Seoul 04554, Korea.
   Department of Policy Development, National Development Institute of Korean Medicine, Seoul 04554, Korea.
   Department of Policy Development, National Development Institute of Korean Medicine, Seoul 04554, Korea.
   Division of Clinical Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Korea.
   Division of Clinical Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Korea.
   College of Korean Medicine, Dongshin University, Naju 58245, Korea.
NR 0
TC 0
SN 2072-665
EI 
J9 Toxins (Basel)
PD FEB 5
PY 2021
VL 13
IS 2
BP 
EP 
DI 10.3390/toxins13020105 
PG 0
WC Acupuncture Therapy; adverse effects; Amphibian Venoms; adverse effects; Animals; Bee Venoms; adverse effects; Humans; Medicine, Korean Traditional; Republic of Korea; Snake Venoms; adverse effects; Treatment Outcome
UT PubMed:33535603
PM 33535603
DA 2021-02-05
ER

PT J
AU Wong, YM
AF Wong, Yiu Ming
TI Importance of a Proper Design for Sham Acupuncture Treatment.
SO Journal of acupuncture and meridian studies
LA English
DT Letter
C1 Health Science Unit (PEC), Hong Kong Physically Handicapped & Able Bodied Association, Shamshuipo, Hong Kong. 
EM pt@hkphab.org.hk
NR 0
TC 0
SN 2093-815
EI 
J9 J Acupunct Meridian Stud
PD FEB 21
PY 2016
VL 9
IS 1
BP 1,3
EP 1,3
DI 10.1016/j.jams.2015.11.034 
PG 1
WC Aromatase Inhibitors; adverse effects; Arthralgia; etiology; Breast Neoplasms; drug therapy; Female; Humans; Multicenter Studies as Topic; standards
UT PubMed:26896069
PM 26896069
DA 2016-02-21
ER

PT J
AU Lin, Y
   Yang, W
   Li, Y
   Li, Y
   Tong, Q
   Ma, W
   Li, Y
   Shen, W
AF Lin, Yufang
   Yang, Wei
   Li, Yajuan
   Li, Yin
   Tong, Qiuyu
   Ma, Wen
   Li, Yijing
   Shen, Weidong
TI [Mechanism of acupoint transcutaneous electric stimulation on analgesic 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupint transcutaneous electric stimulation; analgesic anesthesia; anorectal operation; immunity; stress
AB OBJECTIVE: To observe the regulatory effects of acupoint electric stimulation on 
   the analgesic substances and the relevant indices of nerve-immunity-endocrine 
   system in the patients undergoing general anesthesia anorectal operation. 
   METHODS: One hundred and fifty-six patients undergoing hemorrhoids and anal 
   fistula operation were randomized into three groups, 146 cases were included in 
   the analysis. In the No.1 group (48 cases), the conventional intravenous general 
   anesthesia was applied. In the No.2 group (50 cases), besides the conventional 
   intravenous general anesthesia, the acupoint transcutaneous electric stimulation 
   was combined at Neiguan (PC 6), Shenmen (HT 7), Shangliao (BL 31) and Ciliao (BL 
   32). operation in the No.2 and No.3 groups were lower apparently than that in the 
   No.1 group (P<0.05, P<0.01). CONCLUSIONS: During the general anesthesia anorectal 
   operation, the acupoint transcutaneous electric stimulation achieves analgesic 
   anesthesia through effectively promoting the release of body analgesic substance 
   and reducing the stress level in the operation. With the comprehensive acupoint 
   selection as Neiguan (PC 6) and Shenmen (HT 7) and the local acupoints, the 
   therapeutic effects are better in comparison with the simple selection of local 
   acupoints. In the No.3 group (48 cases), besides the conventional intravenous 
   general anesthesia, the acupoint transcutaneous electric stimulation was combined 
   at Shangliao (BL 31) and Ciliao (BL 32). The electric stimulation was maintained 
   till the end of operation. The patients' saliva was collected 0.5 h before 
   operation and 1 h after operation separately. The indices that reflect the body 
   pain regulation and nerve-immune-endocrine secretion were detected, such as 
   opiophin protein (OPI), secretory immunoglobulin A (SIgA), saliva amylase (sAA), 
   cortisol (Cor) and tumor necrosis factor α (TNF-α). The pain degree was observed 
   1 h after operation. RESULTS: In the No.2 group, OPI after operation was higher 
   than that before operation (P<0.05). The difference value of OPI in the No.2 
   group was higher apparently than that in the No.1 group and the No.3 group (both 
   P<0.05). SIgA after operation was higher than that before operation in the No.1 
   group (P<0.05). The difference values of SIgA, sAA, Cor in the No.2 group were 
   lower apparently than those in the No.1 group (P<0.05, P<0.01). TNF-αbefore and 
   after operation and its difference value among the groups were not significant 
   statistically (all P>0.05). The pain degrees in 1 h after.
C1 Shanghai University of TCM, Shanghai 201203, China.
   Department of Acupuncture and Moxibustion.
   Department of Proctology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203.
   Department of Acupuncture and Moxibustion.
   Department of Acupuncture and Moxibustion.
   Department of Acupuncture and Moxibustion.
   Department of Acupuncture and Moxibustion.
   Department of Acupuncture and Moxibustion.
   Department of Acupuncture and Moxibustion.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD DEC 13
PY 2017
VL 37
IS 7
BP 747
EP 752
DI 10.13703/j.0255-2930.2017.07.017 
PG 5
WC Acupuncture Analgesia; Acupuncture Points; Anesthesia, General; Anesthesia, Intravenous; Electric Stimulation; Hemorrhoidectomy; methods; Humans; Rectal Fistula; surgery; Transcutaneous Electric Nerve Stimulation
UT PubMed:29231549
PM 29231549
DA 2017-12-13
ER

PT J
AU Hu, QS
   Zhang, QR
   Jia, CS
   Peng, Y
   Tan, L
AF Hu, Qiu-sheng
   Zhang, Qing-ru
   Jia, Chun-sheng
   Peng, Yang
   Tan, Liang
TI [Randomized controlled clinical trials of red-hot filiform needle puncturing for 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
AB OBJECTIVE: To observe the effect of red-hot filiform needle puncturing on the 
   pain severity of knee ostarthritis (OA) and the inflammatory cytokine levels in 
   the knee articular cavity (KAC) fluid in senile knee OA patients so as to find a 
   better therapy for knee OA. METHODS: A total of 200 senile knee OA outpatients 
   (who signed an informed consent) were randomized into treatment group and control 
   group (n = 100/group) according to a random number table and their visiting 
   sequence. Futu (LI 18), Neixiyan (EX-LE 4), Yanglingquan (GB 34), Yinlingquan (SP 
   9), Zusanli (ST 36), etc. on the affected side of the body were punctured with 
   red-hot filiform needles (cauterized on an alcohol burner) or routine filiform 
   needles, with the needles retained for 30 min. The treatment was conducted once 
   every other day, 15 sessions altogether. Before and after the treatment, the 
   patients' KAC fluid was sampled for assaying the contents of IL-1, IL-6 and tumor 
   necrosis factor (TNF)-alpha with enzyme-linked immunosorbent assay (ELISA). The 
   pain severity was tested by using visual analogue scale (VAS) and the 
   comprehensive therapeutic effect was evaluated by using clinical symptoms and 
   signs, functional activity and pain degrees. RESULTS: In comparison with 
   pre-treatment, IL-1, IL-6 and TNF-alpha contents in KAC fluid were decreased 
   significantly in both treatment and control groups (P < 0.01). The IL-1, IL-6 and 
   TNF-alpha levels were considerably lower in the treatment group than in the 
   control group following the treatment (P < 0.01), suggesting a marked relief of 
   inflammation in the affected knee joint. Compared to pre-treatment, the severity 
   scores of illness state of both treatment and control groups were decreased 
   remarkably (P < 0.01), and the VAS score of the treatment group was significantly 
   lower than that of the control group after the treatment (P < 0.05). Of the two 
   100 knee OA outpatients in the treatment and control groups, 29 (29%) and 21 
   (21%) were controlled in their symptoms and signs; 46 (46%) and 34 (34%) 
   experienced apparent improvement; 18 (18%) and 29 (29%) were effective; 7 (7%) 
   and 16 (16%) failed in the treatment. The comprehensive therapeutic effect of the 
   treatment group was significantly superior to that of the control group (P < 
   0.01). CONCLUSION: Red-hot filiform needle puncturing is superior to routine 
   filiform needle puncturing in relieving senile knee OA and in reducing 
   inflammatory cytokine levels in knee OA patients.
C1 Convalescent Center of Hebei Yiling Hospital, Shijiazhuang 050091, China.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUL 2
PY 2011
VL 36
IS 2
BP 110
EP 5
DI 
PG -105
WC Acupuncture Therapy; Aged; Cartilage, Articular; immunology; Cytokines; immunology; Female; Humans; Knee Joint; immunology; Male; Middle Aged; Osteoarthritis, Knee; immunology; Synovial Fluid; immunology
UT PubMed:21717778
PM 21717778
DA 2011-07-02
ER

PT J
AU Tang, SK
   Tse, MMY
   Leung, SF
   Fotis, T
AF Tang, Shuk Kwan
   Tse, Mimi Mun Yee
   Leung, Sau Fong
   Fotis, Theofanis
TI The effectiveness, suitability, and sustainability of non-pharmacological methods 
SO BMC public health
LA English
DT Journal Article
DE Aged; Chronic pain; Community-dwelling; Complementary therapy; Non-pharmacological interventions; Older adults; Systematic review
AB BACKGROUND: Pain is common in older adults. To maintain their quality of life and 
   promote healthy ageing in the community, it is important to lower their pain 
   levels. Pharmacological pain management has been shown to be effective in older 
   adults. However, as drugs can have various side effects, non-pharmacological pain 
   management is preferred for community-dwelling older adults. This systematic 
   review evaluates the effectiveness, suitability, and sustainability of 
   non-pharmacological pain management interventions for community-dwelling older 
   adults. METHODS: Five databases, namely, CINHAL, Journals@Ovid, Medline, 
   PsycInfo, and PubMed, were searched for articles. The criteria for inclusion 
   were: full-text articles published in English from 2005 to February 2019 on 
   randomized controlled trials, with chronic non-cancer pain as the primary 
   outcome, in which pain was rated by intensity, using non-pharmacological 
   interventions, and with participants over 65 years old, community-dwelling, and 
   mentally competent. A quality appraisal using the Jadad Scale was conducted on 
   the included articles. RESULTS: Ten articles were included. The mean age of the 
   older adults was from 66.75 to 76. The interventions covered were acupressure, 
   acupuncture, guided imagery, qigong, periosteal stimulation, and Tai Chi. The 
   pain intensities of the participants decreased after the implementation of the 
   intervention. The net changes in pain intensity ranged from - 3.13 to - 0.65 on a 
   zero to ten numeric rating scale, in which zero indicates no pain and ten 
   represents the worst pain. CONCLUSIONS: Non-pharmacological methods of managing 
   pain were effective in lowering pain levels in community-dwelling older adults, 
   and can be promoted widely in the community.
C1 School of Nursing, The Hong Kong Polytechnic University, Kowloon, Hong Kong. skangel.tang@connect.polyu.hk.
   School of Nursing, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
   School of Nursing, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
   School of Health Sciences, University of Brighton, Westlain House, Village Way, Brighton, BN1 9PH, UK.
NR 0
TC 0
SN 1471-245
EI 
J9 BMC Public Health
PD NOV 11
PY 2019
VL 19
IS 1
BP 1488
EP 1488
DI 10.1186/s12889-019-7831-9 
PG 0
WC Aged; Analgesics, Opioid; therapeutic use; Chronic Pain; therapy; Complementary Therapies; methods; Female; Humans; Independent Living; statistics & numerical data; Male; Pain Management; methods; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome
UT PubMed:31703654
PM 31703654
DA 2019-11-11
ER

PT J
AU Li, XJ
   Li, FX
   Jing, WY
   Liu, C
   Liu, LM
   Zhang, XH
   Zhang, FF
   Chen, P
   DU, XZ
AF Li, Xiang-Jun
   Li, Fu-Xin
   Jing, Wei-Yao
   Liu, Cui
   Liu, Li-Mei
   Zhang, Xing-Hua
   Zhang, Feng-Fan
   Chen, Ping
   DU, Xiao-Zheng
TI Effect of heat-reinforcing needling on hypoxia-inducible factor 1α and glycolysis 
SO Zhen ci yan jiu = Acupuncture research
LA chi
DT Journal Article
DE Glycolysis; Heat-reinforcing needling; Hypoxia-inducible factor-1α; Inflammatory response; Rheumatoid arthritis
AB OBJECTIVES: To observe the effect of heat-reinforcing needling (HRN) on synovial 
   inflammation, hypoxia-inducible factor-1α (HIF-1α) and glycolytic activity in 
   serum and synovial tissue in rabbits with cold syndrome of rheumatoid arthritis 
   (RA), so as to explore its mechanisms underlying improvement of RA. METHODS: A 
   total of 32 rabbits were randomly divided into normal, model, inhibitor and HRN 
   groups, with 8 rabbits in each group. The RA with cold syndrome model was induced 
   by injecting ovalbumin dry powder and Freund's complete adjuvant combined with 
   cold freezing. Rabbits in the inhibitor group were intraperitoneally injected 
   with 2-methoxyestradiol (2.5 mg/kg), rabbits in the HRN group were received HRN 
   at bilateral "Zusanli" (ST36) for 30 min. The treatments were conducted once 
   daily for 14 consecutive days. After the interventions, the knee circumference 
   and pain threshold were measured. The contents of nicotinamide adenine 
   dinucleotide phosphoric (NADPH), Hexokinase II (HK2) and 
   6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) in serum of 
   rabbits were detected by ELISA. The pathological morphology of synovial tissue of 
   the knee joints were observed by HE staining. The positive expressions of tumor 
   necrosis factor (TNF-α), interleukin (IL)-1β, IL-6 and IL-17 in synovial tissue 
   of knee joint were detected by immunohistochemistry. The content of lactic acid 
   in synovial tissue of rabbit knee joint was detected by spectrophotometry. The 
   expression levels of HIF-1α, pyruvate kinase 2 (PKM2) and lactate dehydrogenase 
   (LDHA) in synovial tissue of knee joint were detected by Western blot. RESULTS: 
   After intervention, compared with the normal group, the knee circumference was 
   significantly enlarged (P<0.05), the pain threshold was significantly decreased 
   (P<0.05)；the synovial tissue of knee joints showed significant cell proliferation 
   and inflammatory infiltration, the pathological score was significantly increased 
   (P<0.05)；positive expressions of TNF-α, IL-1β, IL-6 and IL-17, the content of 
   lactic acid in synovial tissue, the contents of NADPH, HK2 and PFKFB3 in serum, 
   and the protein expression levels of HIF-1α, PKM2 and LDHA in synovial tissue 
   were increased (all P<0.05) in the model group. Compared with model group, the 
   circumference of knee joint was significantly decreased (P<0.05), the pain 
   threshold was significantly increased (P<0.05)；in synovial tissue, the 
   pathological score was decreased (P<0.05)；the positive expressions of TNF-α, 
   IL-1β, IL-6 and IL-17 in synovial tissue were decreased (P<0.05), the lactic acid 
   content in synovial tissue was decreased (P<0.05)；the contents of NADPH, HK2 and 
   PFKFB3 in serum and the protein expression levels of HIF-1α, PKM2 and LDHA in 
   synovial tissue were decreased (P<0.05) in inhibitor group and HRN group. 
   Compared with the inhibitor group, the synovial pathological score was 
   significantly increased (P<0.05), positive expressions of TNF-α, IL-1β, IL-6 and 
   IL-17, the content of lactic acid in synovial tissue, the contents of NADPH, HK2 
   and PFKFB3 in serum, and the protein expression levels of HIF-1α, PKM2 and LDHA 
   in synovial tissue were increased (all P<0.05) in HRN group. CONCLUSIONS: HRN can 
   increase the pain threshold, reduce the knee circumference and inhibit the 
   inflammatory response in rabbits with cold syndrome of RA. The possible mechanism 
   is related to the down-regulation of HIF-1α and glycolysis activity.
C1 Department of Rheumatology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China.
   College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000.
   College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000.
   College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000.
   College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000.
   Department of Acupuncture and Moxibustion, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050.
   Department of Rheumatology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China.
   Department of Rheumatology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China.
   College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000. lz-duxiaozheng@163.com.
NR 0
TC 0
SN 
EI 1000-060
J9 Zhen Ci Yan Jiu
PD JUN 20
PY 2024
VL 49
IS 6
BP 585
EP 593
DI 10.13702/j.1000-0607.20230487 
PG 8
WC Animals; Rabbits; Hypoxia-Inducible Factor 1, alpha Subunit; metabolism; Glycolysis; Humans; Arthritis, Rheumatoid; therapy; Male; Acupuncture Therapy; Female; Tumor Necrosis Factor-alpha; metabolism; Acupuncture Points; Interleukin-6; genetics
UT PubMed:38897802
PM 38897802
DA 2024-06-20
ER

PT J
AU Zhang, Y
   Wu, B
   Qin, P
   Cheng, Y
   Chen, Y
AF Zhang, Yuxing
   Wu, Bangqi
   Qin, Peng
   Cheng, Yupei
   Chen, Yuyan
TI Alternative therapies in chronic non-cancer pain management: A scoping review of 
SO Complementary therapies in medicine
LA English
DT Journal Article
DE Chronic non-cancer pain; Complementary therapies; Pain management; Personalized treatment. Non-pharmacological therapy; Scoping review
AB BACKGROUND: Chronic pain is one of the most challenging health problems in modern 
   society, placing significant burdens on individuals and healthcare systems. While 
   pharmacological treatments remain the primary approach to pain management, their 
   limitations often restrict choices for both clinicians and patients. In contrast, 
   complementary therapies are gaining recognition for their potential effectiveness 
   and safety. However, the current literature lacks a comprehensive summary of the 
   role of complementary therapies in chronic pain management. OBJECTIVE: This 
   review aims to summarize the complementary therapies used in chronic non-cancer 
   pain management, assess their practical applications, identify research gaps and 
   limitations, and provide a comprehensive perspective for the development of 
   chronic non-cancer pain management and personalized pain management strategies. 
   METHODS: This scoping review followed the PRISMA-ScR guidelines. Randomized 
   controlled trials (RCTs) published in the last decade were retrieved from PubMed 
   and Web of Science using the keywords "chronic pain" and "complementary therapy." 
   Non-English studies were excluded. RESULTS: A total of 848 RCTs were identified, 
   of which 128 met the inclusion criteria. The included studies addressed chronic 
   musculoskeletal pain (102 studies), chronic visceral pain (5 studies), chronic 
   neuropathic pain (7 studies), and 13 studies that did not specify the pain type. 
   The complementary therapies investigated included acupuncture, manual therapy, 
   exercise therapy, psychological interventions, mind-body therapies, and physical 
   modalities. CONCLUSION: This review provides preliminary evidence supporting the 
   efficacy and safety of complementary therapies in the management of chronic 
   non-cancer pain. However, methodological and quality-related limitations were 
   identified in the included studies. Future high-quality RCTs are needed to 
   validate the long-term efficacy of these therapies, explore their mechanisms of 
   action, and provide stronger evidence for their clinical application. 
   REGISTRATION: This scoping review is registered on the Open Science Framework 
   (OSF) under the following DOI: https://doi.org/10.17605/OSF.IO/67K32.
C1 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine Acupuncture andMoxibustion, Tianjin 300381, China
   Tianjin University of Traditional ChineseMedicine, Tianjin 301617, China.
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine Acupuncture andMoxibustion, Tianjin 300381, China. 
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine Acupuncture andMoxibustion, Tianjin 300381, China.
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine Acupuncture andMoxibustion, Tianjin 300381, China
   Tianjin University of Traditional ChineseMedicine, Tianjin 301617, China.
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine Acupuncture andMoxibustion, Tianjin 300381, China
   Tianjin University of Traditional ChineseMedicine, Tianjin 301617, China.
EM wbqwbq1980@outlook.com
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD MAR 14
PY 2025
VL 90
IS 
BP 103154
EP 103154
DI 10.1016/j.ctim.2025.103154 
PG 0
WC Humans; Chronic Pain; therapy; Complementary Therapies; methods; Randomized Controlled Trials as Topic; Pain Management; methods
UT PubMed:40081508
PM 40081508
DA 2025-03-14
ER

PT J
AU Harrington, JE
   Baker, BS
   Hoffman, CJ
AF Harrington, J E
   Baker, B S
   Hoffman, C J
TI Effect of an integrated support programme on the concerns and wellbeing of women 
SO Complementary therapies in clinical practice
LA English
DT Journal Article
AB PURPOSE: To carry out a national service evaluation of the integrated cancer 
   support programme offered by The Haven using the Measure Yourself Concerns and 
   Wellbeing (MYCaW) outcome questionnaire. METHODS: Breast cancer survivors who 
   visited one of three Haven centres in the UK completed the MYCaW questionnaire 
   before and after 6 one-hour complementary therapy sessions. RESULTS: 
   Statistically significant decreases in mean baseline scores (indicating 
   improvement) for concerns and wellbeing were observed after treatment: concern 1 
   (5.09 ± 1.04 vs 3.17 ± 1.60, p < 0.0001, n = 402), concern 2 (4.69 ± 1.08 vs 
   3.08 ± 1.56, p < 0.0001, n = 372), and wellbeing (3.30 ± 1.41 vs 2.63 ± 1.28, 
   p < 0.0001, n = 402). The therapies most commonly used were acupuncture, 
   nutrition, massage and aromatherapy, shiatsu, counselling and reflexology. After 
   therapy, 91% of reported scores (n = 328) rated the concern as being a little 
   better, much better or gone. CONCLUSIONS: These findings suggest that women with 
   breast cancer find the Haven integrated support programme valuable for addressing 
   their main concerns and improving their feeling of wellbeing.
C1 The Haven, Effie Road, London SW6 1TB, UK. julia.harrington@thehaven.org.uk
NR 0
TC 0
SN 1873-694
EI 
J9 Complement Ther Clin Pract
PD DEC 27
PY 2011
VL 18
IS 1
BP 10
EP 5
DI 10.1016/j.ctcp.2011.05.002 
PG -5
WC Analgesia; Breast Neoplasms; complications; Complementary Therapies; Fatigue; Female; Health Care Surveys; Hot Flashes; Humans; Pain; Patient Satisfaction; Program Evaluation; Stress, Psychological; Surveys and Questionnaires; United Kingdom; Women's Health; Women's Health Services; standards
UT PubMed:22196567
PM 22196567
DA 2011-12-27
ER

PT J
AU Bulut, ÖÖ
   Özmen, M
   Al, Ali F
   Shaukat, I
   Bağcıer, F
AF Bulut, Özge Özpolat
   Özmen, Mevlüt
   Al Ali, Faisal
   Shaukat, Ismael
   Bağcıer, Fatih
TI Academic and societal impact of cancer pain research: a bibliometric and 
SO Pain management
LA English
DT Journal Article
DE Cancer pain; altmetric analysis; bibliometric analysis; citation; social impact
AB BACKGROUND: Cancer-related pain affects quality of life despite advancements in 
   management. Bibliometric and altmetric analyses provide insights into the 
   academic and societal impact of research. OBJECTIVE: This study analyzed the top 
   100 most-cited articles on cancer-related pain using bibliometric and altmetric 
   indicators, exploring correlations between altmetric scores, citations per year, 
   and total citations. METHODS: A search of the Web of Science Core Collection 
   database was conducted on 2 November 2024, to identify articles related to cancer 
   pain published between 1975 and 2024. The top 100 most-cited articles were 
   selected based on total citation counts. Only English-language articles with 
   full-text access were included. Bibliometric data were collected. Altmetric 
   scores were retrieved using the Altmetric Explorer platform, and correlations 
   were assessed using Spearman's test. RESULTS: The 100 most-cited articles 
   appeared in 35 journals, with PAIN contributing the most (n = 19). Total 
   citations and citations per year showed a strong correlation (r = 0.64), but the 
   correlation between altmetric scores and total citations was weak (r = 0.18). 
   CONCLUSION: This study highlights the academic and societal impact of cancer pain 
   research. The weak correlation between citations and altmetric scores suggests a 
   need for better dissemination strategies to enhance public engagement.
C1 Clinic of Physical Medicine and Rehabilitation, Viransehir State Hospital, Sanliurfa, Turkey.
   Internal Medicine Residency Program, Rosalind Franklin University, Northwestern McHenry Hospital, McHenry, IL, USA.
   Internal Medicine Residency Program, Rosalind Franklin University, Northwestern McHenry Hospital, McHenry, IL, USA.
   Department of Medical Oncology, Northwestern McHenry Hospital Cancer Center, McHenry, IL, USA.
   Department of Physical Medicine and Rehabilitation, University of Health Sciences, Başakşehir çam and Sakura City Hospital, İstanbul, Turkey.
NR 0
TC 0
SN 1758-187
EI 1758-186
J9 Pain Manag
PD JUL 18
PY 2025
VL 15
IS 10
BP 693
EP 702
DI 10.1080/17581869.2025.2535270 
PG 9
WC Bibliometrics; Humans; Cancer Pain; Biomedical Research; statistics & numerical data; Journal Impact Factor
UT PubMed:40678869
PM 40678869
DA 2025-07-18
ER

PT J
AU Wang, W
   Zhou, Y
   Cai, Y
   Wang, S
   Shao, F
   Du, J
   Fang, J
   Liu, J
   Shao, X
   Liu, B
   Fang, J
   Liang, Y
AF Wang, Wen
   Zhou, You
   Cai, Yangqian
   Wang, Sisi
   Shao, Fangbing
   Du, Junying
   Fang, Junfan
   Liu, Jinggen
   Shao, Xiaomei
   Liu, Boyi
   Fang, Jianqiao
   Liang, Yi
TI Phosphoproteomic Profiling of Rat's Dorsal Root Ganglia Reveals mTOR as a 
SO Frontiers in pharmacology
LA English
DT Journal Article
DE bone cancer pain; electro-acupuncture; mTOR; mechanism; protein microarray; proteomic profiling
AB Bone cancer pain (BCP) is a clinical refractory mixed pain involving neuropathic 
   and inflammatory pain, with the underlying mechanisms remaining largely unknown. 
   Electro-acupuncture (EA) can partly alleviate BCP according to previous research. 
   We aim to explore the proteins and major pathways involved in BCP and EA 
   treatment through phosphoproteomic profiling. BCP rat model was built by tibial 
   inoculation of MRMT-1 mammary gland carcinoma cells. Mechanical hyperalgesia 
   determined by paw withdrawal thresholds (PWTs) and bone destruction manifested on 
   the radiographs confirmed the success of modeling, which were attenuated by EA 
   treatment. The differentially expressed phosphorylated proteins (DEPs) 
   co-regulated by BCP modeling and EA treatment in rat dorsal root ganglions (DRGs) 
   were analyzed through PEX100 Protein microarray. Kyoto Encyclopedia of Genes and 
   Genomes (KEGG) analysis revealed that DEPs were significantly enriched in 
   mammalian target of rapamycin (mTOR) signaling pathway. The phosphorylations of 
   mTOR at Ser2448 and Thr2446 were increased in BCP and downregulated by EA. In 
   addition, the phosphorylation of S6K and Akt, markers of the mTOR complex, were 
   also increased in BCP and downregulated by EA. Inhibition of mTOR signaling 
   alleviated the PWTs of BCP rats, while the mTOR agonist impaired the analgesic 
   effect of EA. Thus, our study provided a landscape of protein phosphorylation 
   changes in DRGs of EA-treated BCP rats and revealed that mTOR signaling can be 
   potentially targeted to alleviate BCP by EA treatment.
C1 Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
   Quzhou Municipal Hospital of Traditional Chinese Medicine, Quzhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
   Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College,Zhejiang Chinese Medical University, Hangzhou, China.
NR 0
TC 0
SN 1663-981
EI 1663-981
J9 Front Pharmacol
PD MAY 18
PY 2021
VL 12
IS 
BP 593043
EP 593043
DI 10.3389/fphar.2021.593043 
PG 0
UT PubMed:33995007
PM 33995007
DA 2021-05-18
ER

PT J
AU Fu, YB
   Chen, JW
   Li, B
   Yuan, F
   Sun, JQ
AF Fu, Yuan-Bo
   Chen, Jun-Wei
   Li, Bin
   Yuan, Fang
   Sun, Jing-Qing
TI [Effect of fire needling on mild to moderate knee osteoarthritis and related 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE Western Ontario and McMaster Universities osteoarthritis index (WOMAC) score; fire needling; inflammatory cytokine; knee osteoarthritis
AB OBJECTIVE: To compare the clinical effect of fire needling and filiform needling 
   for mild to moderate knee osteoarthritis (KOA) and observe the influence on 
   related serum inflammatory sytokines. METHODS: A total of 60 patients with mild 
   to moderate KOA were randomly divided into an observation group (30 cases, 4 
   cases dropped off) and a control group (30 cases, 4 cases dropped off). Both 
   groups were given basic health management, and the acupoints of the two groups 
   were Liangqiu (ST 34), Xuehai (SP 10), Neixiyan (EX-LE 4), Dubi (ST 35), 
   Yanglingquan (GB 34) and ashi point. The observation group was treated with fire 
   needling, while the control group was treated with filiform needling. Both groups 
   were treated once every other day, 3 times a week for 2 weeks. The Western 
   Ontario and McMaster University osteoarthritis index (WOAMC) scores of the two 
   groups were compared before treatment, in 1, 2 weeks of treatment and 2, 6 weeks 
   of follow-up. ELISA method was used to detect the levels of serum interleukin 1α 
   (IL-1α), tumor necrosis factor α (TNF-α) and matrix metalloproteinase 3 (MMP-3) 
   before treatment and in 2 weeks of treatment. The clinical effect of the two 
   groups was evaluated in 1, 2 weeks of treatment and 2, 6 weeks of follow-up. 
   RESULTS: At each time point of treatment and follow-up, the pain, stiffness, 
   difficulty of daily activities scores and WOMAC total scores of the two groups 
   were lower than those before treatment (P<0.05); the stiffness score of the 
   observation group was lower than that of the control group in 1 week of treatment 
   (P<0.05); the various scores and total scores of the WOMAC scale of the 
   observation group were lower than those of the control group in 1, 2 weeks of 
   treatment and 2, 6 weeks of follow-up (P<0.05). In 2 weeks of treatment, the 
   levels of serum MMP-3 and IL-1α in the observation group and IL-1α in the control 
   group were higher than those before treatment (P<0.05). In 1 week of treatment 
   and 2, 6 weeks of follow-up, the total effective rates of the observation group 
   were higher than those in the control group (P<0.05). CONCLUSION: Fire needling 
   can improve the pain, stiffness and joint dysfunction of patients with mild to 
   moderate KOA, and increase serum MMP-3 and IL-1α levels. Its short and long term 
   clinical effects are better than filiform needling.
C1 Department of Acupuncture and Moxibustion, Capital Medical University, Beijing 100010, China
   Beijing Key Laboratory of Acupuncture Neuromodulation, BeijingHospital of TCM, Capital Medical University, Beijing 100010, China
   BeijingHuairou District Hospital of TCM, Beijing 101400.
   Department of Acupuncture and Moxibustion, Capital Medical University, Beijing 100010, China
   Beijing Key Laboratory of Acupuncture Neuromodulation, BeijingHospital of TCM, Capital Medical University, Beijing 100010, China
   BeijingUniversity of CM.
   Department of Acupuncture and Moxibustion, Beijing Hospital of TCM, Capital Medical University, Beijing 100010, China
   Beijing Key Laboratory of AcupunctureNeuromodulation, Beijing Hospital of TCM, Capital Medical University, Beijing100010, China.
   Department of Acupuncture and Moxibustion, Beijing Hospital of TCM, Capital Medical University, Beijing 100010, China
   Beijing Key Laboratory of AcupunctureNeuromodulation, Beijing Hospital of TCM, Capital Medical University, Beijing100010, China.
   Department of Acupuncture and Moxibustion, Beijing Hospital of TCM, Capital Medical University, Beijing 100010, China;Beijing Key Laboratory of AcupunctureNeuromodulation, Beijing Hospital of TCM, Capital Medical University, Beijing100010, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD MAY 19
PY 2021
VL 41
IS 5
BP 493
EP 7
DI 10.13703/j.0255-2930.20200708-k0003 
PG -486
WC Acupuncture Points; Acupuncture Therapy; Cytokines; Humans; Osteoarthritis, Knee; therapy; Treatment Outcome
UT PubMed:34002561
PM 34002561
DA 2021-05-19
ER

PT J
AU Popescu, RA
   Roila, F
   Arends, J
   Metro, G
   Lustberg, M
AF Popescu, Razvan Andrei
   Roila, Fausto
   Arends, Jann
   Metro, Giulio
   Lustberg, Maryam
TI Supportive Care: Low Cost, High Value.
SO American Society of Clinical Oncology educational book. American Society of 
LA English
DT Journal Article
AB Supportive care aims to prevent and manage adverse effects of cancer and its 
   treatment across the entire disease continuum. Research and clinical experience 
   in dedicated centers have demonstrated that early appropriate supportive care 
   interventions improve symptoms, quality of life, and overall survival in a 
   cost-effective manner. The challenge is to assess symptoms and needs with 
   validated tools regularly and, ideally, between clinic appointments; electronic 
   patient-reported outcome measures and dedicated easily accessible supportive care 
   units can help. As management of certain problems improves, others come to the 
   fore. Cancer-related fatigue and malnutrition are very frequent and need regular 
   screening, assessment of treatable causes, and early intervention to improve. 
   Pharmacologic agents and phytopharmaceuticals are of little use, but other 
   interventions are valuable: physical exercise, counseling on fatigue, and 
   cognitive behavioral therapy/mind-body interventions (e.g., for fatigue). 
   Nutrition should be oral, rich in proteins, and accompanied by muscle training 
   adapted to the patient's condition. Psychological and societal counseling is 
   often useful; nausea or other problems such as gastrointestinal dysmotility or 
   metabolic derangements must be tackled. Chemotherapy-induced peripheral 
   neuropathy frequently worsens quality of life and has no established prevention 
   strategy (notwithstanding current interest in cryotherapy and compression 
   therapy) and thus requires careful assessment of patient predisposition to 
   develop it with the consideration of feasible dose and treatment alternatives. 
   When painful, duloxetine helps. Nonpharmacologic strategies, including 
   acupuncture, physical exercise, cryotherapy/compression, and scrambler therapy, 
   are promising but require large phase III trials to become the accepted standard. 
   Personalization of chemotherapy, dependent on realistic goals, is key.
C1 Tumor Zentrum Aarau and Hirslanden Clinic Aarau, Aarau, Switzerland.
   Medical Oncology, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
   Department of Medicine I, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
   Medical Oncology, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
   Division of Medical Oncology, The Ohio State University, Columbus, OH.
NR 0
TC 0
SN 1548-875
EI 
J9 Am Soc Clin Oncol Educ Book
PD APR 9
PY 2021
VL 41
IS 
BP 1
EP 11
DI 10.1200/EDBK_320041 
PG 10
WC Exercise; Fatigue; Humans; Neoplasms; diagnosis; Pain; Quality of Life
UT PubMed:33830830
PM 33830830
DA 2021-04-09
ER

PT J
AU Zhi, WI
   Gentile, D
   Diller, M
   Kinney, A
   Bao, T
   Master, V
   Wang, XS
AF Zhi, W Iris
   Gentile, Danielle
   Diller, Maggie
   Kinney, Anita
   Bao, Ting
   Master, Viraj
   Wang, Xin Shelley
TI Patient-Reported Outcomes of Pain and Related Symptoms in Integrative Oncology 
SO Oncology (Williston Park, N.Y.)
LA English
DT Review
AB Pain is a primary concern among patients with cancer and cancer survivors. 
   Integrative interventions such as acupuncture, massage, and music therapy are 
   effective nonpharmacologic approaches for cancer pain with low cost and minimal 
   adverse events. Patient-reported outcomes (PROs) that have been validated in many 
   clinical and research settings can be used to evaluate pain intensity, associated 
   symptom burden, and quality of life. Clearly defined, reliable PROs can improve 
   patient satisfaction and symptom control. As integrative oncology continues to 
   evolve and expand, cancer-related pain PROs must be standardized to accurately 
   guide clinicians and researchers. Well-validated pain PROs, such as the Brief 
   Pain Inventory, are among the most commonly used for pain intensity assessment. 
   Multiple symptom assessment tools such as the MD Anderson Symptom Inventory, the 
   Memorial Symptom Assessment Scale, the Edmonton Symptom Assessment System, and 
   the Patient-Reported Outcomes-Common Terminology Criteria for Adverse Events 
   measurement system can also capture pain-associated symptom burden. Electronic 
   PROs provide flexibility in collecting and analyzing PRO data. Clinical trials 
   using carefully selected PROs and rigorous statistical analysis plans are 
   fundamental to conducting high-quality integrative oncology research and 
   promoting utilization of effective integrative interventions to improve patient 
   outcomes. In this review, we aim to summarize current, validated PROs specific to 
   cancer-related pain to aid integrative oncology clinicians and researchers in 
   patient care and in study design and implementation.
C1 Breast Medicine Service, Solid Tumor Division, Memorial Sloan Kettering Cancer Center.
   Department of Supportive Oncology, Levine Cancer Institute.
   Department of Surgery, Winship Cancer Institute, Emory University School of Medicine.
   Department of Biostatistics and Epidemiology, School of Public Health, Rutgers Cancer Institute of New Jersey.
   Integrative Breast Oncology, Integrative Medicine and Breast Medicine Services, Memorial Sloan Kettering Cancer Center.
   Department of Urology, Winship Cancer Institute, Emory University School of Medicine.
   Department of Symptom Research, The University of Texas MD Anderson Cancer Center.
NR 0
TC 0
SN 
EI 0890-909
J9 Oncology (Williston Park)
PD JAN 15
PY 2021
VL 35
IS 1
BP 35
EP 41
DI 10.46883/ONC.2021.3501.0035 
PG 6
WC Cancer Pain; therapy; Evidence-Based Practice; organization & administration; Humans; Integrative Oncology; methods; Pain Measurement; Patient Reported Outcome Measures; Patient Satisfaction; Quality of Life
UT PubMed:33443769
PM 33443769
DA 2021-01-15
ER

PT J
AU Tao, X
   Lee, MS
   Donnelly, CR
   Ji, RR
AF Tao, Xueshu
   Lee, Michael S
   Donnelly, Christopher R
   Ji, Ru-Rong
TI Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain.
SO Neurotherapeutics : the journal of the American Society for Experimental 
LA English
DT Review
DE Auricular stimulation; chemotherapy; dorsal root ganglion; fish oil; resolvin; vagus nerve stimulation
AB The current crises in opioid abuse and chronic pain call for the development of 
   nonopioid and nonpharmacological therapeutics for pain relief. 
   Neuromodulation-based approaches, such as spinal cord stimulation, dorsal root 
   ganglion simulation, and nerve stimulation including vagus nerve stimulation, 
   have shown efficacy in achieving pain control in preclinical and clinical 
   studies. However, the mechanisms by which neuromodulation alleviates pain are not 
   fully understood. Accumulating evidence suggests that neuromodulation regulates 
   inflammation and neuroinflammation-a localized inflammation in peripheral nerves, 
   dorsal root ganglia/trigeminal ganglia, and spinal cord/brain-through 
   neuro-immune interactions. Specialized proresolving mediators (SPMs) such as 
   resolvins, protectins, maresins, and lipoxins are lipid molecules produced during 
   the resolution phase of inflammation and exhibit multiple beneficial effects in 
   resolving inflammation in various animal models. Recent studies suggest that SPMs 
   inhibit inflammatory pain, postoperative pain, neuropathic pain, and cancer pain 
   in rodent models via immune, glial, and neuronal modulations. It is noteworthy 
   that sham surgery is sufficient to elevate resolvin levels and may serve as a 
   model of resolution. Interestingly, it has been shown that the vagus nerve 
   produces SPMs and vagus nerve stimulation (VNS) induces SPM production in vitro. 
   In this review, we discuss how neuromodulation such as VNS controls pain via 
   immunomodulation and neuro-immune interactions and highlight possible involvement 
   of SPMs. In particular, we demonstrate that VNS via auricular electroacupuncture 
   effectively attenuates chemotherapy-induced neuropathic pain. Furthermore, 
   auricular stimulation is able to increase resolvin levels in mice. Thus, we 
   propose that neuromodulation may control pain and inflammation/neuroinflammatioin 
   via SPMs. Finally, we discuss key questions that remain unanswered in our 
   understanding of how neuromodulation-based therapies provide short-term and 
   long-term pain relief.
C1 Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, 27710, USA.
   Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, 27710, USA.
   Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, 27710, USA.
   Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, 27710, USA. ru-rong.ji@duke.edu.
   Department of Neurobiology, Duke University Medical Center, Durham, NC, 27710, 
   Department of Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA. ru-rong.ji@duke.edu.
NR 0
TC 0
SN 1878-747
EI 1933-721
J9 Neurotherapeutics
PD JUL 23
PY 2020
VL 17
IS 3
BP 886
EP 899
DI 10.1007/s13311-020-00892-9 
PG 13
WC Analgesics; pharmacology; Animals; Docosahexaenoic Acids; metabolism; Humans; Inflammation Mediators; antagonists & inhibitors; Lipid Metabolism; drug effects; Lipoxins; metabolism; Neuroimmunomodulation; drug effects; Pain; metabolism; Pain Management; methods; Vagus Nerve Stimulation; methods
UT PubMed:32696274
PM 32696274
DA 2020-07-23
ER

PT J
AU Yang, CM
   Chen, NC
   Shen, HC
   Chou, CH
   Yeh, PS
   Lin, HJ
   Chang, CY
   Cheng, TJ
   Lin, KC
AF Yang, Chun-Ming
   Chen, Nan-Cheng
   Shen, Hsiu-Chu
   Chou, Chi-Ho
   Yeh, Poh-Shiow
   Lin, Huey-Juan
   Chang, Chia-Yu
   Cheng, Tain-Junn
   Lin, Kao-Chang
TI [Guideline of neuropathic pain treatment and dilemma from neurological point of 
SO Acta neurologica Taiwanica
LA chi
DT Journal Article
AB Neuropathic pain is a complicated symptomatic disease as migraine in recent 
   years. Not because the pain character differed from the nociceptive inflammatory 
   symptoms but because of its complexity of mechanisms. Though peripheral 
   sensitization, ectopic discharge, central sensitization, central re-organization 
   and loss of inhibition play part of roles in mechanisms, however, based on this 
   mechanistic treatment, the outcome still disappointed physicians and patients, 
   exampled as central post-stroke central pain (CPSP). The pain reduction is far 
   less than the expectation from patients and physician's under-treatment 
   frequently occur due to the fear of adverse effects or off-label use of these 
   anti-neuropathic pain drugs. Therefore, a multidisciplinary procedure including 
   non-pharmacological management, rehabilitation program, careful explanation, 
   stepwise pain reduction, daily diary record, and tailored individual planning for 
   medications are helpful in treating this kind of sufferers. Pharmacological 
   treatment is the mainstream in post-herpetic neuralgia (PHN), diabetic peripheral 
   neuropathic pain (DPNP), central post-stroke pain (CPSP), trigeminal neuralgia 
   (TN), complex regional pain syndrome (CRPS), cancer pain, failed back syndrome 
   etc, while polypharmacy is still the major prescriptions facing such kind of 
   miserable patients. The tricyclic antidepressants (TCA), gamma- aminobutyric acid 
   (GABA), voltage-dependent calcium channel blockers, selective non-epinephrine 
   reuptake inhibitor (SNRI), opioid or morphine etc, are still evidence-based 
   medicines (EBM) but with different outcome for individuals. Acupuncture is to 
   some extend effective in Taiwanese people with perceived evidence or placebo. The 
   Taiwan guidance for total pain management and review of EBM in treating 
   neuropathic pain from neurological point of view will be introduced in this 
   manuscript.
C1 Department of Neurology, Chi Mei Medical Center, Taiwan.
NR 0
TC 0
SN 
EI 1028-768
J9 Acta Neurol Taiwan
PD DEC 1
PY 2012
VL 21
IS 3
BP 136
EP 44
DI 
PG -92
WC Analgesics; therapeutic use; Guidelines as Topic; Humans; Neuralgia; etiology
UT PubMed:23196735
PM 23196735
DA 2012-12-01
ER

PT J
AU Znidarsic, J
   Kirksey, KN
   Dombrowski, SM
   Tang, A
   Lopez, R
   Blonsky, H
   Todorov, I
   Schneeberger, D
   Doyle, J
   Libertini, L
   Jamie, S
   Segall, T
   Bang, A
   Barringer, K
   Judi, B
   Ehrman, JP
   Roizen, MF
   Golubić, M
AF Znidarsic, Josie
   Kirksey, Kellie N
   Dombrowski, Stephen M
   Tang, Anne
   Lopez, Rocio
   Blonsky, Heather
   Todorov, Irina
   Schneeberger, Dana
   Doyle, Jonathan
   Libertini, Linda
   Jamie, Starkey
   Segall, Tracy
   Bang, Andrew
   Barringer, Kathy
   Judi, Bar
   Ehrman, Jane Pernotto
   Roizen, Michael F
   Golubić, Mladen
TI "Living Well with Chronic Pain": Integrative Pain Management via Shared Medical 
SO Pain medicine (Malden, Mass.)
LA English
DT Journal Article
DE Chronic Pain; Opioids; Pain Management
AB OBJECTIVE: To evaluate the effectiveness of a multidisciplinary, 
   nonpharmacological, integrative approach that uses shared medical appointments to 
   improve health-related quality of life and reduce opioid medication use in 
   patients with chronic pain. DESIGN: This is a retrospective, pre-post review of 
   "Living Well with Chronic Pain" shared medical appointments (August 2016 through 
   May 2018). SETTING: The appointments included eight 3-hour-long visits held once 
   per week at an outpatient wellness facility. SUBJECTS: Patients with chronic, 
   non-cancer-related pain. METHODS: Patients received evaluation and evidence-based 
   therapies from a team of integrative and lifestyle medicine professionals, as 
   well as education about nonpharmacological therapeutic approaches, the etiology 
   of pain, and the relationship of pain to lifestyle factors. Experiential elements 
   focused on the relaxation techniques of meditation, yoga, breathing, and 
   hypnotherapy, while patients also received acupuncture, acupressure, massage, 
   cognitive behavioral therapy, and chiropractic education. Patients self-reported 
   data via the Patient-Reported Outcomes Measurement Information System (PROMIS-57) 
   standardized questionnaire. Use of opioid medications was evaluated in morphine 
   milligram equivalents. RESULTS: A total of 178 participants completed the 
   PROMIS-57 questionnaire at the first and the last visits. Statistically 
   significant improvements in all domains (Physical Functioning, Anxiety, 
   Depression, Fatigue, Social Roles, Pain Interference, and Sleep Disturbance) were 
   observed (P < 0.001) between the pre-intervention (visit 1) and post-intervention 
   (visit 8) scores. Average opioid use decreased nonsignificantly over the 8-week 
   intervention, but the lower rate of opioid use was not sustained at 6 and 
   12 months' follow-up. CONCLUSIONS: Patients suffering from chronic pain who 
   participated in a multidisciplinary, nonpharmacological treatment approach 
   delivered via shared medical appointments experienced reduced pain and improved 
   measures of physical, mental, and social health without increased use of opioid 
   pain medications.
NR 0
TC 0
SN 1526-463
EI 1526-237
J9 Pain Med
PD FEB 6
PY 2021
VL 22
IS 1
BP 181
EP 190
DI 10.1093/pm/pnaa418 
PG 9
WC Chronic Pain; therapy; Humans; Pain Management; Quality of Life; Retrospective Studies; Shared Medical Appointments
UT PubMed:33543263
PM 33543263
DA 2021-02-06
ER

PT J
AU Panicker, L
   Prasun, MA
   Stockmann, C
   Simon, J
AF Panicker, Latha
   Prasun, Marilyn A
   Stockmann, Cherrill
   Simon, Jolene
TI Evaluation of Chronic, Noncancer Pain Management Initiative in a 
SO Pain management nursing : official journal of the American Society of Pain 
LA English
DT Journal Article
AB BACKGROUND: Chronic pain management is a major challenge for primary care 
   providers (PCPs). PCPs manage many patients with chronic pain and other 
   comorbidities including mental health problems like post-traumatic stress 
   disorder (PTSD) and depression. Chronic pain and opioid problems are a national 
   crisis, particularly among veterans (U.S. Department of Veterans Affairs, 2019). 
   There are many veterans with chronic non-cancer pain who are being treated with 
   opioids. Chronic opioid use has contributed to an epidemic of opioid-related 
   adverse events (VA, 2017). Opioids not only result in poor pain control, but have 
   associated risks such as misuse, overdose, and diversion which may be fatal 
   (Frieden & Houry, 2016). AIMS: The aim of this project was to evaluate chronic 
   non-cancer pain management of veterans using an advanced practice registered 
   nurse (APRN)-led multidisciplinary team approach to incorporate non-opioid and 
   non-pharmacologic modalities to affect self-reported pain and use of prescribed 
   opioids. METHODS: A retrospective quality improvement (QI) project was conducted 
   in the multidisciplinary pain (MDP) clinic. The APRN used a biopsychosocial 
   approach for chronic pain management guided by the Plan, Do, Study, Act (PDSA) 
   cycle framework. Thirty-four patients who were utilizing opioids for pain 
   management were included using convenience sampling from the MDP clinic. The APRN 
   educated and treated patients with non-opioid medications and non-pharmacolog 
   therapies. A 10-point pain scale and morphine equivalent daily dose (MEDD) were 
   utilized pre- and post-intervention to evaluate the MDP clinic. RESULTS: 
   Participants were predominantly male (91.8%), with a mean age of 63.18 ± 15.39 
   years, and 36.4% of whom were retired. Only 20.6% of the participants reported 
   the use of opioids for <12 months. Low back pain (93%) was the most common pain 
   location. The mean baseline MEDD was 41.04 and the post tapered MEDD was 23.05; 
   this revealed a significant decline in MEDD (p < .0001). A decline was also found 
   between pre- and post-pain scores (ranges 0-8). There was a significant reported 
   decline in pain scores with a baseline of 6.11 to post tapering pain of 3.1 
   (t = 4.99, df = 28, p < .0001). Participants preferred non-opioid medications 94% 
   and non-pharmacologic therapy 86%, like physical therapy, yoga, and acupuncture. 
   Fifty-one percent of patients were referred for injections and 46% were referred 
   to primary care behavior health, which includes pain school, sleep hygiene 
   classes, and cognitive behavior therapy. CONCLUSIONS: APRNs are in a key position 
   to assess and treat patients based on current evidence while facilitating opioid 
   titration. This initiative highlights that safe tapering of opioids is possible 
   when utilizing a multidisciplinary approach for chronic pain management. Findings 
   support the use of non-pharmacologic and non-opioid therapy for chronic pain 
   management which can result in reduced patient-reported pain. Further research is 
   warranted to examine both pharmacologic (non-opioid) and non-pharmacologic 
   strategies that promote pain management while tapering opioids.
C1 Illinois State University Mennonite College of Nursing, Normal, Illinois
   Edward Hines Junior VA Hospital, Hines, Illinois. 
   Illinois State University Mennonite College of Nursing, Normal, Illinois.
   Illinois State University Mennonite College of Nursing, Normal, Illinois.
   Edward Hines Junior VA Hospital, Hines, Illinois.
EM atha.panicker@va.gov
NR 0
TC 0
SN 1532-863
EI 
J9 Pain Manag Nurs
PD NOV 11
PY 2021
VL 23
IS 2
BP 122
EP 127
DI 10.1016/j.pmn.2021.09.003 
PG 5
WC Aged; Analgesics, Opioid; adverse effects; Chronic Pain; drug therapy; Humans; Male; Middle Aged; Morphine; therapeutic use; Pain Clinics; Pain Management; Retrospective Studies
UT PubMed:34756689
PM 34756689
DA 2021-11-11
ER

PT J
AU Xue, Y
   Dai, S
   Liang, J
   Ji, W
AF Xue, Yan
   Dai, Sailin
   Liang, Jiexian
   Ji, Wenjin
TI Effect of reactive oxygen species of the psoas major muscle in complete Freund's 
SO Molecular pain
LA English
DT Journal Article
DE Lower limb pain; PBN; complete Freund’s adjuvant-induced inflammatory pain; psoas major muscle; reactive oxygen species
AB Lower limb pain is a common clinical disease that affects millions of people 
   worldwide. It is found in previous studies that reactive oxygen species is 
   closely related to neuropathic, cancer, chemotherapy, and inflammatory pain, 
   which can be relieved by reactive oxygen species scavengers. Furthermore, 
   acupuncture or electroacupuncture on the psoas major muscle has a great effect on 
   adjuvant-induced arthritis and lower back pain. In our study, we investigated the 
   function of reactive oxygen species scavengers locally injecting into the 
   ipsilateral psoas major muscle on complete Freund's adjuvant-induced inflammatory 
   pain. Our results demonstrated that in the development of complete Freund's 
   adjuvant-induced inflammatory pain, early local continuous application of 
   N-tert-Butyl-α-phenylnitrone (PBN, 1 and 5 mg/kg/0.2 ml) on the ipsilateral psoas 
   major muscle effectively reduced mechanical and cold hyperalgesia. However, 
   intraperitoneal injection of PBN (1 and 5 mg/kg) or local injection of PBN (1 and 
   5 mg/kg/0.2 ml) into contralateral psoas major muscle, ipsilateral quadratus 
   lumborum, and ipsilateral erector spinae showed limited effect. In the developed 
   inflammatory pain model, local injection of PBN into the ipsilateral psoas major 
   muscle also alleviated pain and paw edema. In addition, reactive oxygen species 
   level increased in ipsilateral psoas major muscle at seven days after complete 
   Freund's adjuvant injection. In general, PBN reduces complete Freund's 
   adjuvant-evoked inflammatory pain by inhibiting reactive oxygen species in the 
   psoas major muscle.
C1 Division of Anesthesiology, Department of Cardiovascular Surgery, Guangdong Institute of Cardiovascular, Guangdong Provincial People's Hospital, GuangdongAcademy of Medical Sciences, School of Medicine, South China University ofTechnology, Guangzhou, China.
   Department of Anesthesiology, Guangdong Provincial People's Hospital, Guangdong 
   Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
   Division of Anesthesiology, Department of Cardiovascular Surgery, Guangdong Institute of Cardiovascular, Guangdong Provincial People's Hospital, GuangdongAcademy of Medical Sciences, School of Medicine, South China University ofTechnology, Guangzhou, China.
   Department of Anesthesiology, Guangdong Provincial People's Hospital, Guangdong 
   Department of Anesthesiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
NR 0
TC 0
SN 1744-806
EI 
J9 Mol Pain
PD JUN 20
PY 2020
VL 16
IS 
BP 1744806920929246
EP 1744806920929246
DI 10.1177/1744806920929246 
PG 1
WC Animals; Cyclic N-Oxides; administration & dosage; Freund's Adjuvant; administration & dosage; Inflammation; complications; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Muscles; pathology; Pain; complications; Pain Threshold; Rats, Sprague-Dawley; Reactive Oxygen Species; metabolism
UT PubMed:32552357
PM 32552357
DA 2020-06-20
ER

PT J
AU Li, H
   Shang, XJ
   Dong, QR
AF Li, Huan
   Shang, Xiao-Jun
   Dong, Qi-Rong
TI Effects of transcutaneous electrical nerve stimulation on rats with the third 
SO Acupuncture in medicine : journal of the British Medical Acupuncture Society
LA English
DT Journal Article
DE PAIN MANAGEMENT
AB OBJECTIVE: To investigate the analgesic and anti-inflammatory effects of 
   transcutaneous electrical nerve stimulation (TENS) at local or distant 
   acupuncture points in a rat model of the third lumbar vertebrae transverse 
   process syndrome. METHODS: Forty Sprague-Dawley rats were randomly divided into 
   control, model, model plus local acupuncture point stimulation at BL23 
   (model+LAS) and model plus distant acupuncture point stimulation at ST36 
   (model+DAS) groups. All rats except controls underwent surgical third lumbar 
   vertebrae transverse process syndrome modelling on day 2. Thereafter, rats in the 
   model+LAS and model+DAS groups were treated daily with TENS for a total of six 
   treatments (2/100 Hz, 30 min/day) from day 16 to day 29. Thermal pain thresholds 
   were measured once a week during treatment and were continued until day 57, when 
   local muscle tissue was sampled for RT-PCR and histopathological examination 
   after haematoxylin and eosin staining. mRNA expression of interleukin-1 β 
   (IL-1β), tumour necrosis factor-α (TNF-α) and inducible nitric oxide synthase 
   (iNOS) was determined. RESULTS: Thermal pain thresholds of all model rats 
   decreased relative to the control group. Both LAS and DAS significantly increased 
   the thermal pain threshold at all but one point during the treatment period. 
   Histopathological assessment revealed that the local muscle tissues around the 
   third lumbar vertebrae transverse process recovered to some degree in both the 
   model+LAS and model+DAS groups; however, LAS appeared to have a greater effect. 
   mRNA expression of IL-1β, TNF-α and iNOS in the local muscle tissues was 
   increased after modelling and attenuated in both model+LAS and model+DAS groups. 
   The beneficial effect was greater after LAS than after DAS. CONCLUSIONS: TENS at 
   both local (BL23) and distant (ST36) acupuncture points had a pain-relieving 
   effect in rats with the third lumbar vertebrae transverse process syndrome, and 
   LAS appeared to have greater anti-inflammatory and analgesic effects than DAS. 
   TRIAL REGISTRATION NUMBER: 09073.
C1 Department of Orthopaedics, The Second Affiliated Hospital of Suzhou University, Suzhou, China Department of Orthopaedics, The First People's Hospital ofChangzhou and the Third Affiliated Hospital of Suzhou University, Changzhou,China.
   Department of Orthopaedics, The First People's Hospital of Changzhou and the Third Affiliated Hospital of Suzhou University, Changzhou, China.
   Department of Orthopaedics, The Second Affiliated Hospital of Suzhou University, Suzhou, China.
NR 0
TC 0
SN 1759-987
EI 
J9 Acupunct Med
PD JUN 25
PY 2015
VL 33
IS 5
BP 400
EP 5
DI 10.1136/acupmed-2014-010752 
PG -395
WC Animals; Disease Models, Animal; Low Back Pain; therapy; Lumbar Vertebrae; injuries; Male; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Fractures; pathology; Transcutaneous Electric Nerve Stimulation
UT PubMed:26104377
PM 26104377
DA 2015-06-25
ER

PT J
AU Kim, W
   Kim, MJ
   Go, D
   Min, BI
   Na, HS
   Kim, SK
AF Kim, Woojin
   Kim, Min Joon
   Go, Donghyun
   Min, Byung-Il
   Na, Heung Sik
   Kim, Sun Kwang
TI Combined Effects of Bee Venom Acupuncture and Morphine on Oxaliplatin-Induced 
SO Toxins
LA English
DT Journal Article
DE bee venom acupuncture; chemotherapy induced neuropathic pain; morphine; oxaliplatin
AB Oxaliplatin, a chemotherapeutic drug for colorectal cancer, induces severe 
   peripheral neuropathy. Bee venom acupuncture (BVA) has been used to attenuate 
   pain, and its effect is known to be mediated by spinal noradrenergic and 
   serotonergic receptors. Morphine is a well-known opioid used to treat different 
   types of pain. Here, we investigated whether treatment with a combination of 
   these two agents has an additive effect on oxaliplatin-induced neuropathic pain 
   in mice. To assess cold and mechanical allodynia, acetone and von Frey filament 
   tests were used, respectively. Significant allodynia signs were observed three 
   days after an oxaliplatin injection (6 mg/kg, i.p.). BVA (0.25, 1, and 2.5 mg/kg, 
   s.c., ST36) or morphine (0.5, 2, and 5 mg/kg, i.p.) alone showed dose-dependent 
   anti-allodynic effects. The combination of BVA and morphine at intermediate doses 
   showed a greater and longer effect than either BVA or morphine alone at the 
   highest dose. Intrathecal pretreatment with the opioidergic (naloxone, 20 μg) or 
   5-HT3 (MDL-72222, 15 μg) receptor antagonist, but not with α2 adrenergic 
   (idazoxan, 10 μg) receptor antagonist, blocked this additive effect. Therefore, 
   we suggest that the combination effect of BVA and morphine is mediated by spinal 
   opioidergic and 5-HT3 receptors and this combination has a robust and enduring 
   analgesic action against oxaliplatin-induced neuropathic pain.
C1 Department of Physiology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdamoon-gu, Seoul 02447, Korea. thasnow@gmail.com.
   Department of East-West Medicine, Graduate School, Kyung Hee University, 26 
   Department of East-West Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdamoon-gu, Seoul 02447, Korea. junesnest@naver.com.
   Department of East-West Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdamoon-gu, Seoul 02447, Korea. drum2r@daum.net.
   Yeongju Municipal Hospital, 697 Jangan-ro, Anjeong-myeon, Gyeongsangbuk-do, Yeongju-si 36051, Korea. mbi@khu.ac.kr.
   Department of Physiology, College of Medicine, Korea University, Anam-dong 5-ga, Seongbuk-gu, Seoul 02842, Korea. hsna@korea.ac.kr.
   Department of Physiology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdamoon-gu, Seoul 02447, Korea. skkim77@khu.ac.kr.
   Department of East-West Medicine, Graduate School, Kyung Hee University, 26 
NR 0
TC 0
SN 2072-665
EI 
J9 Toxins (Basel)
PD JAN 26
PY 2016
VL 8
IS 2
BP 33
EP 33
DI 10.3390/toxins8020033 
PG 0
WC Acupuncture; Analgesics; therapeutic use; Animals; Antineoplastic Agents; adverse effects; Bee Venoms; therapeutic use; Cold Temperature; Combined Modality Therapy; Hyperalgesia; chemically induced; Male; Mice, Inbred C57BL; Morphine; therapeutic use; Naloxone; pharmacology; Narcotic Antagonists; pharmacology; Neuralgia; chemically induced; Organoplatinum Compounds; adverse effects; Oxaliplatin; Physical Stimulation; Receptors, Opioid; metabolism; Receptors, Serotonin, 5-HT3; metabolism; Serotonin 5-HT3 Receptor Antagonists; pharmacology; Tropanes; pharmacology
UT PubMed:26805884
PM 26805884
DA 2016-01-26
ER

PT J
AU Ling, F
   Qi, W
   Li, X
   Zhou, J
   Xiong, J
   Zhao, Y
   Zheng, Q
   Liang, F
AF Ling, Fayang
   Qi, Wenchuan
   Li, Xiao
   Zhou, Jun
   Xiong, Jian
   Zhao, Yi
   Zheng, Qianhua
   Liang, Fanrong
TI Bibliometric Analysis of Acupuncture Therapy for Cancer Pain Over the Past 10 
SO Journal of pain research
LA English
DT Review
DE CiteSpace; acupuncture analgesia; bibliometric analysis; cancer; pain
AB PURPOSE: Cancer pain is a common symptom of cancer patients and greatly affects 
   quality of life. Acupuncture has certain curative effects on cancer pain. The aim 
   of this study was to analyze and visualize the current status and research trend 
   of acupuncture treatment for cancer pain over the last 10 years and provide 
   directions for future development. METHODS: A search of the Web of Science Core 
   Collection from 2012-01-01 to 2022-08-20 was performed to collect studies related 
   to acupuncture therapy for cancer pain. CiteSpace was used to conduct 
   bibliometric analysis and visualization from the perspective of the volume of 
   annual publications, journals, nations, institutions, authors, keywords, and 
   references. RESULTS: A total of 302 studies were included in the analysis. The 
   number of publications increased steadily with some fluctuations over the past 
   decade. Integrative Cancer Therapies was the journal with the most relevant 
   publications, and the Journal of Clinical Oncology was the most frequently cited 
   journal. China had the highest volume of publications, and the USA contributed 
   most to international collaboration. The most prolific institution was Memorial 
   Sloan Kettering Cancer Center. The most productive author was Mao JJ, and the 
   most influential author was Lu WD. "Acupuncture" was the top keyword in frequency 
   and centrality. The references with the highest frequency and centrality were 
   published by HE, Y, and Ting Bao, respectively. CONCLUSION: A stable development 
   trend has formed in this field. The overall collaborative network needs to be 
   strengthened. Breast cancer and multiple myeloma, electroacupuncture and bee 
   venom acupuncture, postoperative pain, peripheral neuropathic pain syndrome, and 
   aromatase inhibitors-associated arthralgia syndrome are research hotspots in this 
   field. Randomized controlled trials (RCTs), evidence-based evaluations and 
   mechanisms (cancer-induced bone pain) are research trends and frontiers.
C1 Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine/Clinical Research Center for Acupuncture and Moxibustion in SichuanProvince, Chengdu, People's Republic of China.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD MAR 28
PY 2023
VL 16
IS 
BP 985
EP 1003
DI 10.2147/JPR.S395421 
PG 18
UT PubMed:36968762
PM 36968762
DA 2023-03-28
ER

PT J
AU Pritchard, KT
   Baillargeon, J
   Lee, WC
   Raji, MA
   Kuo, YF
AF Pritchard, Kevin T
   Baillargeon, Jacques
   Lee, Wei-Chen
   Raji, Mukaila A
   Kuo, Yong-Fang
TI Trends in the Use of Opioids vs Nonpharmacologic Treatments in Adults With Pain, 
SO JAMA network open
LA English
DT Journal Article
AB IMPORTANCE: Chronic pain prevalence among US adults increased between 2010 and 
   2019. Yet little is known about trends in the use of prescription opioids and 
   nonpharmacologic alternatives in treating pain. OBJECTIVES: To compare annual 
   trends in the use of prescription opioids, nonpharmacologic alternatives, both 
   treatments, and neither treatment; compare estimates for the annual use of 
   acupuncture, chiropractic care, massage therapy, occupational therapy, and 
   physical therapy; and estimate the association between calendar year and pain 
   treatment based on the severity of pain interference. DESIGN, SETTING, AND 
   PARTICIPANTS: A serial cross-sectional analysis was conducted using the 
   nationally representative Medical Expenditure Panel Survey to estimate the use of 
   outpatient services by cancer-free adults with chronic or surgical pain between 
   calendar years 2011 and 2019. Data analysis was performed from December 29, 2021, 
   to August 5, 2022. EXPOSURES: Calendar year (2011-2019) was the primary exposure. 
   MAIN OUTCOMES AND MEASURES: The association between calendar year and mutually 
   exclusive pain treatments (opioid vs nonpharmacologic vs both vs neither 
   treatment) was examined. A secondary outcome was the prevalence of 
   nonpharmacologic treatments (acupuncture, chiropractic care, massage therapy, 
   occupational therapy, and physical therapy). All analyses were stratified by pain 
   type. RESULTS: Among the unweighted 46 420 respondents, 9643 (20.4% weighted) 
   received surgery and 36 777 (79.6% weighted) did not. Weighted percentages 
   indicated that 41.7% of the respondents were aged 45 to 64 years and 55.0% were 
   women. There were significant trends in the use of pain treatments after 
   adjusting for demographic factors, socioeconomic status, health conditions, and 
   pain severity. For example, exclusive use of nonpharmacologic treatments 
   increased in 2019 for both cohorts (chronic pain: adjusted odds ratio [aOR], 
   2.72; 95% CI, 2.30-3.21; surgical pain: aOR, 1.53; 95% CI, 1.13-2.08) compared 
   with 2011. The use of neither treatment decreased in 2019 for both cohorts 
   (chronic pain: aOR, 0.43; 95% CI, 0.37-0.49; surgical pain: aOR, 0.59; 95% CI, 
   0.46-0.75) compared with 2011. Among nonpharmacologic treatments, chiropractors 
   and physical therapists were the most common licensed healthcare professionals. 
   CONCLUSIONS AND RELEVANCE: Among cancer-free adults with pain, the annual 
   prevalence of nonpharmacologic pain treatments increased and the prevalent use of 
   neither opioids nor nonpharmacologic therapy decreased for both chronic and 
   surgical pain cohorts. These findings suggest that, although access to outpatient 
   nonpharmacologic treatments is increasing, more severe pain interference may 
   inhibit this access.
C1 Department of Nutrition, Metabolism, and Rehabilitation Sciences, School of Public and Population Health, University of Texas Medical Branch, Galveston.
   Department of Epidemiology, School of Public and Population Health, University of Texas Medical Branch, Galveston.
   Department of Internal Medicine, University of Texas Medical Branch, Galveston.
   Department of Internal Medicine, University of Texas Medical Branch, Galveston.
   Department of Biostatistics and Data Science, School of Public and Population Health, University of Texas Medical Branch, Galveston.
NR 0
TC 0
SN 2574-380
EI 
J9 JAMA Netw Open
PD NOV 8
PY 2022
VL 5
IS 11
BP e2240612
EP e2240612
DI 10.1001/jamanetworkopen.2022.40612 
PG 1
WC Adult; Female; Humans; Male; Analgesics, Opioid; therapeutic use; Chronic Pain; drug therapy; Cross-Sectional Studies; Pain Management; Physical Therapy Modalities
UT PubMed:36342717
PM 36342717
DA 2022-11-08
ER

PT J
AU Bosco, F
   Cidin, S
   Maceri, F
   Ghilli, M
   Roncella, M
   De, Simone L
AF Bosco, F
   Cidin, S
   Maceri, F
   Ghilli, M
   Roncella, M
   De Simone, L
TI An integrated approach with homeopathic medicine and electro-acupuncture in 
SO Journal of pharmacopuncture
LA English
DT Journal Article
DE Anaesthesiology; Breast cancer; Electro-acupuncture; Homeopathy; Multidisciplinary approach
AB This study investigates the effect of a combination of homeopathic medicine and 
   electro-acupuncture in two patients with breast cancer and severe liver disease 
   who could not receive standard anaesthesia therapy due to liver problems. 
   Specifically, measurable and quantifiable parameters were used to evaluate 
   whether an integrated approach-consisting of electro-acupuncture and a 
   homeopathic medicine diluted above Avogadro's limit (that is, above a potency of 
   12CH) during the pre-surgical, surgical and post-surgical phases--can improve 
   general well-being of a patient undergoing breast cancer surgery. In breast 
   cancer surgery, we employed an integrated approach consisting of induction with 
   hypnotics and muscle relaxants, followed by maintenance with anaesthetic gas, 
   combined with a homeopathic treatment (Arnica montana 15CH and Apis mellifica 
   15CH) before and after surgery and an electro-acupuncture treatment performed in 
   the pre- and post-surgical phases without any analgesic/pain relieving 
   medications. Both of the patients treated with the integrated approach improved 
   their overall condition without need for other common pain relieving medicines. 
   Additionally, thanks to their rapid awakening, the patients were not relocated to 
   a protected area and the hospitalization was shorter. A multidisciplinary 
   approach incorporating homeopathic medicine and electro-acupuncture can be a 
   solution for patients who need or ask about a different and/or safer alternative 
   to the standard treatment. This approach can offer a safe, much less expensive, 
   non-invasive and viable alternative for such cases. Moreover it can be useful for 
   an opioids free anesthesia.
C1 S.D. Anaesthesia and Intensive Care MiSC AOUP Complementary Medicine Oncology Integrated Breast Unit, University Hospital Trust ofPisa, Via Roma 67, 56126,Pisa, Italy.
   S.D. Anaesthesia and Intensive Care MiSC AOUP Complementary Medicine Oncology Integrated Breast Unit, University Hospital Trust ofPisa, Via Roma 67, 56126,Pisa, Italy.
   S.D. Anaesthesia and Intensive Care MiSC AOUP Complementary Medicine Oncology Integrated Breast Unit, University Hospital Trust ofPisa, Via Roma 67, 56126,Pisa, Italy.
   Breast Cancer Surgical Unit, University Hospital Trust of Pisa, Via Roma 67, 56126, Pisa, Italy.
   Breast Cancer Surgical Unit, University Hospital Trust of Pisa, Via Roma 67, 56126, Pisa, Italy.
   S.D. Anaesthesia and Intensive Care MiSC AOUP Complementary Medicine Oncology Integrated Breast Unit, University Hospital Trust ofPisa, Via Roma 67, 56126,Pisa, Italy.
NR 0
TC 0
SN 2234-685
EI 2093-696
J9 J Pharmacopuncture
PD AUG 29
PY 2018
VL 21
IS 2
BP 126
EP 131
DI 10.3831/KPI.2018.21.016 
PG 5
UT PubMed:30151314
PM 30151314
DA 2018-08-29
ER

PT J
AU Puerto, Valencia LM
   He, Y
   Wippert, PM
AF Puerto Valencia, Laura Maria
   He, Yangyang
   Wippert, Pia-Maria
TI The changes of blood-based inflammatory biomarkers after non-pharmacologic 
SO BMC musculoskeletal disorders
LA English
DT Journal Article
DE Anti-inflammatory cytokines; Interleukin; Pain management; Pro-inflammatory cytokines; Tumor necrosis factor alpha
AB BACKGROUND: Chronic low back pain (CLBP) is a prevalent and debilitating 
   condition, leading to significant challenges to both patients and the 
   governmental healthcare system. Non-pharmacologic interventions have received 
   increasing attention as potential strategies to alleviate chronic low back pain 
   and improve patient outcomes. The aim of this systematic review was to 
   comprehensively assess the changes in blood inflammatory biomarkers after 
   non-pharmacologic interventions for CLBP patients, thus trying to understand the 
   complex interactions between non-pharmacologic interventions and inflammatory 
   biomarker changes in CLBP. METHODS: A thorough search (from January 1st, 2002 to 
   October 5th, 2022) of PubMed, Medline (platform Web of Science), and the Cochrane 
   Library (platform Wiley Online Library) were conducted, and inclusion criteria as 
   well as exclusion criteria were refined to selection of the studies. Rigorous 
   assessments of study quality were performed using RoB 2 from Cochrane or an 
   adaptation of the Downs and Black checklist. Data synthesis includes alterations 
   in inflammatory biomarkers after various non-pharmacologic interventions, 
   including exercise, acupressure, neuro-emotional technique, and other modalities. 
   RESULTS: Thirteen primary studies were included in this systematic review, eight 
   randomized controlled trials, one quasi-randomized trial, and four before-after 
   studies. The interventions studied consisted of osteopathic manual treatment (one 
   study), spinal manipulative therapy (SMT) (three studies), exercise (two 
   studies), yoga (two studies) and acupressure (two studies), neuro-emotional 
   technique (one study), mindfulness-based (one study) and balneotherapy study (one 
   study). Four studies reported some changes in the inflammatory biomarkers 
   compared to the control group. Decreased tumor necrosis factor-alpha (TNF-α) 
   after osteopathic manual treatment (OMT), neuro-emotional technique (NET), and 
   yoga. Decreased interleukin (IL)-1, IL-6, IL-10, and c-reactive protein (CRP) 
   after NET, and increased IL-4 after acupressure. Another five studies found 
   changes in inflammatory biomarkers through pre- and post-intervention 
   comparisons, indicating improvement outcomes after intervention. Increased IL-10 
   after balneotherapy; decreased TNF-α, IL-1β, IL-8, Interferon-gamma, 
   interferon-γ-induced protein 10-γ-induced protein 10 after exercise; decreased 
   IL-6 after exercise and SMT; decreased CRP and chemokine ligand 3 after SMT. 
   CONCLUSION: Results suggest a moderation of inflammatory biomarkers due to 
   different non-pharmacologic interventions for CLBP, generally resulting in 
   decreased pro-inflammatory markers such as TNF-α and IL-6 as well as increased 
   anti-inflammatory markers such as IL-4, thus revealing the inhibition of 
   inflammatory processes by different non-pharmacologic interventions. However, a 
   limited number of high-quality studies evaluating similar interventions and 
   similar biomarkers limits the conclusion of this review.
C1 Medical Sociology and Psychobiology, University of Potsdam, Potsdam, Germany.
   Medical Sociology and Psychobiology, University of Potsdam, Potsdam, Germany.
   Faculty of Health Sciences Brandenburg [joint Faculty, Brandenburg Medical School 
   Medical Sociology and Psychobiology, University of Potsdam, Potsdam, Germany. wippert@uni-potsdam.de.
   Faculty of Health Sciences Brandenburg [joint Faculty, Brandenburg Medical School 
NR 0
TC 0
SN 1471-247
EI 
J9 BMC Musculoskelet Disord
PD MAR 9
PY 2024
VL 25
IS 1
BP 209
EP 209
DI 10.1186/s12891-024-07289-1 
PG 0
WC Humans; Low Back Pain; diagnosis; Interleukin-10; Tumor Necrosis Factor-alpha; Interleukin-6; Interferon-gamma; Interleukin-4; Biomarkers; Chronic Pain; diagnosis; Randomized Controlled Trials as Topic
UT PubMed:38459458
PM 38459458
DA 2024-03-09
ER

PT J
AU Zhou, K
   Jia, P
   Bhargava, S
   Zhang, Y
   Reza, T
   Peng, YB
   Wang, GG
AF Zhou, Kehua
   Jia, Peng
   Bhargava, Swati
   Zhang, Yong
   Reza, Taslima
   Peng, Yuan Bo
   Wang, Gary G
TI Opioid tapering in patients with prescription opioid use disorder: A 
SO Scandinavian journal of pain
LA English
DT Journal Article
DE Chronic non-cancer pain; Medication assisted treatment; Methadone; Opioid use disorder
AB BACKGROUND AND AIMS: Opioid use disorder (OUD) refers to a maladaptive pattern of 
   opioid use leading to clinically significant impairment or distress. OUD causes, 
   and vice versa, misuses and abuse of opioid medications. Clinicians face daily 
   challenges to treat patients with prescription opioid use disorder. An 
   evidence-based management for people who are already addicted to opioids has been 
   identified as the national priority in the US; however, options are limited in 
   clinical practices. In this study, we aimed to explore the success rate and 
   important adjuvant medications in the medication assisted treatment with 
   temporary use of methadone for opioid discontinuation in patients with 
   prescription OUD. METHODS: This is a retrospective chart review performed at a 
   private physician office for physical medicine and rehabilitation. We reviewed 
   all medical records dated between December 1st, 2011 and August 30th, 2016. The 
   initial evaluation of the included patients (N=140) was completed between 
   December 1st, 2011 and December 31st, 2014. They all have concumittant 
   prescription OUD and chronic non-cancer pain. The patients (87 female and 53 
   male) were 46.7±12.7 years old, and had a history of opioid use of 7.7±6.1 years. 
   All patients received the comprehensive opioid taper treatments (including 
   interventional pain management techniques, psychotherapy, acupuncture, physical 
   modalities and exercises, and adjuvant medications) on top of the medication 
   assisted treatment using methadone (transient use). Opioid tapering was 
   considered successful when no opioid medication was used in the last patient 
   visit. RESULTS: The 140 patients had pain of 9.6±8.4 years with 8/10 intensity 
   before treatment which decreased after treatment in all comparisons (p<0.001 for 
   all). Opioids were successfully tapered off in 39 (27.9%) patients after 6.6±6.7 
   visits over 8.8±7.2 months; these patients maintained opioid abstinence over 
   14.3±13.0 months with regular office visits. Among the 101 patients with 
   unsuccessful opioid tapering, 13 patients only visited the outpatient clinic 
   once. Significant differences were found between patients with and without 
   successful opioid tapering in treatment duration, number of clinic visits, the 
   use of mirtazepine, bupropion, topiramate, and trigger point injections with the 
   univariate analyses. The use of mirtazepine (OR, 3.75; 95% CI, 1.48-9.49), 
   topiramate (OR, 5.61; 95% CI, 1.91-16.48), or bupropion (OR, 2.5; 95% CI, 
   1.08-5.81) was significantly associated with successful opioid tapering. The 
   associations remain significant for mirtazepine and topiramate (not bupropion) in 
   different adjusted models. CONCLUSIONS: With comprehensive treatments, 27.9% of 
   patients had successful opioid tapering with opioid abstinence for over a year. 
   The use of mirtazepine, topiramate, or likely bupropion was associated with 
   successful opioid tapering in the medication assisted treatment with temporary 
   use of methadone. Opioid tapering may be a practical option and should be 
   considered for managing prescription OUD. IMPLICATIONS: For patients with OUD, 
   indefinite opioid maintenance treatment may not be necessary. Considering the 
   ethical values of autonomy, nonmaleficence, and beneficence, clinicians should 
   provide patients with OUD the option of opioid tapering.
C1 Catholic Health System Internal Medicine Training Program, Sisters of Charity Hospital, University at Buffalo, 2157 Main Street, Buffalo, NY 14214, UnitedStates. 
   Faculty of Geo-information Science and Earth Observation (ITC), University of Twente, Enschede 7500, The Netherlands. 
   Catholic Health System Internal Medicine Training Program, Sisters of Charity Hospital, University at Buffalo, 2157 Main Street, Buffalo, NY 14214, UnitedStates. 
   School of Public Health and Health Management, Chongqing Medical University, Chongqing 400016, China. 
   Academic Buffalonias in Physical Medicine and Rehabilitation, 2121 Main St #210, Buffalo, NY 14214, United States
   Avalon University School of Medicine,Youngstown, OH, United States. 
   Department of Psychology, University of Texas at Arlington, 501 S Nedderman Dr., Arlington, TX 76019-0528, United States. 
   Catholic Health System Internal Medicine Training Program, Sisters of Charity Hospital, University at Buffalo, 2157 Main Street, Buffalo, NY 14214, UnitedStates
   Academic Buffalonias in Physical Medicine and Rehabilitation, 2121 MainSt #210, Buffalo, NY 14214, United States. 
EM angwang2017@gmail.com
NR 0
TC 0
SN 1877-887
EI 
J9 Scand J Pain
PD OCT 11
PY 2017
VL 17
IS 
BP 167
EP 173
DI 10.1016/j.sjpain.2017.09.005 
PG 6
WC Analgesics, Opioid; administration & dosage; Chronic Pain; drug therapy; Drug Prescriptions; Female; Humans; Male; Methadone; administration & dosage; Middle Aged; Opiate Substitution Treatment; Opioid-Related Disorders; drug therapy; Pain; drug therapy; Pain Management; methods; Retrospective Studies
UT PubMed:28988103
PM 28988103
DA 2017-10-11
ER

PT J
AU Majithia, N
   Loprinzi, CL
   Smith, TJ
AF Majithia, Neil
   Loprinzi, Charles L
   Smith, Thomas J
TI New Practical Approaches to Chemotherapy-Induced Neuropathic Pain: Prevention, 
SO Oncology (Williston Park, N.Y.)
LA English
DT Review
AB Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most disabling 
   and demoralizing problems that arise for cancer survivors. When investigating 
   symptoms of numbness, tingling, or pain in the extremities, it is critical to 
   determine whether the problem is neuropathic, somatic, or mixed. If the diagnosis 
   is CIPN, it is important to weigh the potential benefits and harms of possible 
   treatment options, and to devise an evidence-based multimodality treatment 
   program. Such programs may include mixtures of opioid and nonopioid adjunctive 
   medications, based on evidence from CIPN trials, and also extrapolation from 
   trials in patients with other neuropathic pain syndromes-although such 
   extrapolating must be done with caution, since other syndromes sometimes respond 
   to agents that CIPN does not respond to. Other components of a successful program 
   might include exercise; and possibly neuromodulation via acupuncture, spinal cord 
   electrical stimulation, or neurocutaneous stimulation. There is good randomized 
   trial evidence that most of the anticonvulsants and tricyclic antidepressants 
   typically prescribed for neuropathic pain have little or no effect on CIPN, but 
   there is some evidence of efficacy for duloxetine-however, clinical practice with 
   regard to pharmacologic treatment of CIPN often does not reflect these data. We 
   review here the recommendations of the American Society of Clinical Oncology, as 
   well as some new and promising approaches to neuropathy, including new 
   neuromodulation techniques.
NR 0
TC 0
SN 
EI 0890-909
J9 Oncology (Williston Park)
PD NOV 18
PY 2016
VL 30
IS 11
BP 1020
EP 9
DI 
PG -1011
WC Analgesics; therapeutic use; Antineoplastic Agents; adverse effects; Duloxetine Hydrochloride; therapeutic use; Humans; Neuralgia; chemically induced; Pain Management; Peripheral Nervous System Diseases; chemically induced; Randomized Controlled Trials as Topic
UT PubMed:27854104
PM 27854104
DA 2016-11-18
ER

PT J
AU Geagea, D
   Tyack, Z
   Kimble, R
   Polito, V
   Ayoub, B
   Terhune, DB
   Griffin, B
AF Geagea, Dali
   Tyack, Zephanie
   Kimble, Roy
   Polito, Vince
   Ayoub, Bassel
   Terhune, Devin B
   Griffin, Bronwyn
TI Clinical Hypnosis for Procedural Pain and Distress in Children: A Scoping Review.
SO Pain medicine (Malden, Mass.)
LA English
DT Journal Article
DE Children; Clinical Hypnosis; Distress; Procedural Pain; Scoping Review
AB OBJECTIVE: Pain and distress are common in children undergoing medical 
   procedures, exposing them to acute and chronic biopsychosocial impairments if 
   inadequately treated. Clinical hypnosis has emerged as a potentially beneficial 
   treatment for children's procedural pain and distress due to evidence of 
   effectiveness and potential superiority to other psychological interventions. 
   However, systematic reviews of clinical hypnosis for children's procedural pain 
   and distress have been predominantly conducted in children undergoing oncology 
   and needle procedures and are lacking in broader pediatric contexts. This scoping 
   review maps the evidence of clinical hypnosis for children's procedural pain and 
   distress across broad pediatric contexts while highlighting knowledge gaps and 
   areas requiring further investigation. METHODS: Published databases (PubMed, 
   Cochrane Library, PsycINFO, Embase, CINAHL, Scopus, and Web of Science) and grey 
   literature were searched in addition to hand-searching reference lists and key 
   journals (up to May 2022). Two independent reviewers screened the titles and 
   abstracts of search results followed by a full-text review against eligibility 
   criteria. Articles were included if they involved a clinical hypnosis 
   intervention comprising an induction followed by therapeutic suggestions for pain 
   and distress in children undergoing medical procedures. This review followed the 
   Arksey and O'Malley (2005) methodology and incorporated additional scoping review 
   recommendations by the Joanna Briggs Institute and Preferred Reporting Items for 
   Systematic Reviews and Meta-Analyses. RESULTS: A total of 38 eligible studies 
   involving 2,205 children were included after 4,775 articles were screened. 
   Research on clinical hypnosis for children's procedural pain and distress was 
   marked by a lack of fidelity measures and qualitative data as well as by 
   inadequate intervention reporting and high attrition rates. Evidence regarding 
   the safety of clinical hypnosis, pain unpleasantness outcomes, factors 
   influencing outcomes, as well as barriers and facilitators to implementing 
   hypnosis and study procedures was also lacking. Clinical hypnosis has potential 
   benefits for children's procedural pain and distress based on evidence of 
   superiority to control conditions and nonpharmacological interventions (e.g., 
   distraction, acupressure) with moderate to large effect sizes as reported in 76% 
   of studies. However, heterogeneous interventions, contexts, study designs, and 
   populations were identified, and the certainty of the evidence was not evaluated. 
   CONCLUSIONS: The review suggests potential benefits of clinical hypnosis for 
   children's procedural pain and distress and thus provides a precursor for further 
   systematic reviews and trials investigating the effectiveness of clinical 
   hypnosis. The review also indicates the need to further explore the feasibility, 
   acceptability, implementation, and safety of clinical hypnosis in children 
   undergoing painful procedures. Based on the review, researchers implementing 
   clinical hypnosis should adequately report interventions or use treatment 
   manuals, follow recommended research guidelines, and assess the fidelity of 
   intervention delivery to promote replicating and comparing interventions. The 
   review also highlights common methodological shortcomings of published trials to 
   avoid, such as the lack of implementation frameworks, small sample sizes, 
   inadequate reporting of standard care or control conditions, and limited evidence 
   on pain unpleasantness outcomes.
C1 Child Health Research Centre, Centre for Children's Burns and Trauma Research, The University of Queensland, Brisbane, Australia.
   Child Health Research Centre, Centre for Children's Burns and Trauma Research, The University of Queensland, Brisbane, Australia.
   Australian Centre for Health Service Innovation and Centre for Healthcare 
   Centre for Children's Burns and Trauma Research, Queensland Children's Hospital, The University of Queensland, Brisbane, Australia.
   School of Psychological Sciences, Macquarie University, Sydney, Australia.
   Faculty of Health, Queensland University of Technology, Brisbane, Australia.
   Department of Psychology, Goldsmiths University of London, London, UK.
   Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, 
   School of Nursing and Midwifery, Griffith University, Nathan, Queensland, Australia.
NR 0
TC 0
SN 1526-463
EI 1526-237
J9 Pain Med
PD DEC 1
PY 2022
VL 24
IS 6
BP 661
EP 702
DI 10.1093/pm/pnac186 
PG 41
WC Child; Humans; Hypnosis; Needles; Pain; psychology; Pain, Procedural; therapy; Punctures
UT PubMed:36448690
PM 36448690
DA 2022-12-01
ER

PT J
AU Eskander, JP
   Beakley, BD
   Zhang, S
   Paetzold, J
   Sharma, B
   Kaye, AD
   Sharma, S
AF Eskander, Jonathan P
   Beakley, Burton D
   Zhang, Si
   Paetzold, Jacquelyn
   Sharma, Bharat
   Kaye, Alan D
   Sharma, Sanjay
TI A Multimodal Approach to Pain Management for Patients with Chronic Back Pain: 
SO Current pain and headache reports
LA English
DT Journal Article
DE Acupuncture; Cervical; Chronic pain; Cognitive behavioral therapy; Interdisciplinary pain management; Intervention; Interventional; Low back; Multimodal; Nutrition; Pain; Physical therapy; Yoga
AB PURPOSE OF REVIEW: The purpose of this study is to evaluate the effectiveness of 
   a multimodal approach to treating chronic low back pain. RECENT FINDINGS: Chronic 
   non-cancer-related back pain is often a frustrating and poorly managed problem 
   for patients. It poses a significant public health issue worsened by the 
   widespread use of narcotics. In 2016, the CDC released guidelines with noticeably 
   more strict recommendations on prescription of narcotics for pain. Veterans at an 
   interventional pain clinic presenting with chronic back pain refractory to 
   medical and to surgical care were enrolled in an 8-week interdisciplinary pain 
   management program. Pain scores were significantly reduced 1 year after 
   completion of the program. Patients in this study benefitted from lower and 
   sustained pain scores, a reduction in emergency room, and urgent care clinic 
   visits, as well as generally high satisfaction with the interdisciplinary 
   program.
C1 Department of Anesthesiology, Portsmouth Anesthesia Associates, Portsmouth, VA, USA. jeskande@tulane.edu.
   Department of Anesthesiology, Ocshner Health System, New Orleans, LA, USA.
   Department of Anesthesiology, Stamford Health Medical Group, Stamford, CT, USA.
   Department of Anesthesiology, STAR Anesthesia, P.A., San Antonio, TX, USA.
   Department of Anesthesiology, Duke University, Durham, NC, USA.
   Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
   Department of Anesthesiology, Southeast Louisiana Veterans Health Care System, New Orleans, LA, USA.
NR 0
TC 0
SN 1534-308
EI 
J9 Curr Pain Headache Rep
PD JUL 10
PY 2019
VL 23
IS 8
BP 54
EP 54
DI 10.1007/s11916-019-0790-0 
PG 0
WC Adult; Aged; Chronic Pain; therapy; Cognitive Behavioral Therapy; Combined Modality Therapy; methods; Female; Humans; Low Back Pain; therapy; Male; Middle Aged; Pain Management; methods; Physical Therapy Modalities; Yoga
UT PubMed:31286279
PM 31286279
DA 2019-07-10
ER

PT J
AU Jiao, C
   Zhang, T
   Yang, Y
   Zhang, R
   Liu, W
   Wang, Y
   Huang, L
AF Jiao, Chunmeng
   Zhang, Ting
   Yang, Yachen
   Zhang, Ruofan
   Liu, Wenbo
   Wang, Yanqing
   Huang, Lei
TI Progress in Research on Alleviating the Symptoms Associated With Advanced Cancer 
SO Pain research & management
LA English
DT Review
DE Traditional Chinese Medicine; advanced cancer treatment; symptoms of advanced cancer
AB Advanced cancer continues to pose a substantial global challenge, with complex 
   symptom burdens and limited therapeutic options. Traditional Chinese Medicine 
   (TCM), grounded in holistic theory and the principles of syndrome 
   differentiation, employs interventions such as herbal medicine, acupuncture, 
   moxibustion, and acupoint-based therapies to address both the malignancy and the 
   patient's overall functional status. Emerging evidence indicates that TCM may 
   alleviate symptom clusters associated with advanced cancer, enhance quality of 
   life, and potentially contribute to improved survival outcomes. This review 
   synthesizes findings from the past decade on the role of TCM in advanced cancer 
   care, with a focus on herbal decoctions, Chinese herbal injections, 
   acupuncture-either alone or in combination with herbal therapy-moxibustion with 
   adjuvant medication, and other external TCM modalities. Evidence is examined 
   regarding their effects on cancer-related pain, fatigue, gastrointestinal 
   dysfunction, chemotherapy- and radiotherapy-induced toxicities, and immune 
   modulation. By consolidating current clinical and mechanistic insights, this 
   review aims to inform future research and support the integration of 
   evidence-based TCM approaches into contemporary oncology practice.
C1 Chinese Medicine Research Institute, Guangdong Pharmaceutical University, Guangzhou, 510006, China, gdpu.edu.cn.
   Department of Integrative Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai, 200040, China, huashan.org.cn.
   Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Institutes of Integrative Medicine, Fudan University, Shanghai, 200032,China, fudan.edu.cn.
   Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Institutes of Integrative Medicine, Fudan University, Shanghai, 200032,China, fudan.edu.cn.
   Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Institutes of Integrative Medicine, Fudan University, Shanghai, 200032,China, fudan.edu.cn.
   Chinese Medicine Research Institute, Guangdong Pharmaceutical University, Guangzhou, 510006, China, gdpu.edu.cn.
   Department of Integrative Medicine and Neurobiology, School of Basic Medical 
   Shanghai Key Laboratory for Acupuncture Mechanism and Acupoint Function, Shanghai Research Center for Acupuncture and Meridian, Fudan University, Shanghai, 200433,China, fudan.edu.cn.
   Chinese Medicine Research Institute, Guangdong Pharmaceutical University, Guangzhou, 510006, China, gdpu.edu.cn.
   Department of Integrative Medicine, Huashan Hospital Affiliated to Fudan 
   Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Institutes of Integrative Medicine, Fudan University, Shanghai, 200032,China, fudan.edu.cn.
   Shanghai Key Laboratory for Acupuncture Mechanism and Acupoint Function, Shanghai 
NR 0
TC 0
SN 1918-152
EI 
J9 Pain Res Manag
PD JAN 14
PY 2026
VL 2026
IS 
BP 7197339
EP 7197339
DI 10.1155/prm/7197339 
PG 0
WC Humans; Medicine, Chinese Traditional; methods; Neoplasms; therapy; Drugs, Chinese Herbal; therapeutic use
UT PubMed:41531828
PM 41531828
DA 2026-01-14
ER

PT J
AU Childress, MA
   Stuek, SJ
AF Childress, Marc A
   Stuek, Samantha Jayne
TI Neck Pain: Initial Evaluation and Management.
SO American family physician
LA English
DT Review
AB Neck pain is a common presenting symptom in the primary care setting and causes 
   significant disability. The broad differential diagnosis requires an efficient 
   but global assessment; therefore, emphasis is typically placed on red flags that 
   can assist in the early recognition and treatment of more concerning diagnoses, 
   such as traumatic injuries, infection, malignancy, vascular emergencies, and 
   other inflammatory conditions. The critical element in appropriate diagnosis and 
   management of these conditions is an accurate patient history. Physical 
   examination findings complement and refine diagnostic cues from the history but 
   often lack the specificity to be of value independently. Diagnostic tools such as 
   imaging and electrodiagnostic tests have variable utility, especially in chronic 
   or degenerative conditions. Treatment of mechanical or nonneuropathic neck pain 
   includes short-term use of medications and possibly injections. However, 
   long-term data for these interventions are limited. Acupuncture and other 
   complementary and alternative therapies may be helpful in some cases. Advanced 
   imaging and surgical evaluation may be warranted for patients with worsening 
   neurologic function or persistent pain.
C1 Virginia Commonwealth University Fairfax Family Practice, Fairfax, VA, USA.
   Virginia Commonwealth University Fairfax Family Practice, Fairfax, VA, USA.
NR 0
TC 0
SN 1532-065
EI 
J9 Am Fam Physician
PD AUG 1
PY 2020
VL 102
IS 3
BP 150
EP 156
DI 
PG 6
WC Adult; Aged; Aged, 80 and over; Curriculum; Diagnostic Tests, Routine; standards; Education, Medical, Continuing; Female; Guidelines as Topic; Humans; Male; Medical History Taking; standards; Middle Aged; Neck Pain; diagnosis
UT PubMed:32735440
PM 32735440
DA 2020-08-01
ER

PT J
AU Ostovar-Kermani, T
   Arnaud, D
   Almaguer, A
   Garcia, I
   Gonzalez, S
   Mendez, Martinez YH
   Surani, S
AF Ostovar-Kermani, Tiffany
   Arnaud, Daniel
   Almaguer, Andrea
   Garcia, Ismael
   Gonzalez, Stephanie
   Mendez Martinez, Yamely Haydee
   Surani, Salim
TI Painful Sleep: Insomnia in Patients with Chronic Pain Syndrome and its 
SO Folia medica
LA English
DT Review
DE chronic pain syndrome; insomnia; lifestyle impact; mental health; pain; sleep apnea; sleep disorder; somnolence
AB Insomnia is a chronic condition that occurs a minimum of three times per week 
   over a period of three or more subsequent months. There are multiple causes of 
   insomnia, and even though it is considered a symptom, it can be associated with 
   chronic illnesses. Chronic pain syndrome, which is defined as pain that persists 
   for a period longer than 3 months, is one of several etiologies of insomnia. The 
   prevalence of insomnia among chronic pain patients is greater in comparison with 
   the general population (percentage or ratio). Chronic pain is common in patients 
   with rheumatoid arthritis, spinal pain (such as chronic back pain) and 
   fibromyalgia. The prevalence of in-somnia is also higher in cancer patients when 
   compared to the general population. When the clinical history indicates a 
   straightforward diagnosis of chronic pain syndrome, patients will complain of 
   insomnia as part of their symptomatology. It is imperative to manage their 
   underlying illness to alleviate their sleep disorder. Various medications may be 
   used to relieve and even improve pain symptoms. Other than pharmacological 
   interventions, non-pharmacological alternatives such as yoga, meditation, 
   acupuncture, and psychotherapy can help improve the quality of life of these 
   patients. The purpose of this article is to review the diagnosis and management 
   of insomnia in chronic pain syndrome and its impact on the quality of life.
C1 Baylor College of Medicine, Houston, United States of America.
   Horizon Clinical Research, Houston, United States of America.
   Baylor College of Medicine, Houston, United States of America.
   Texas Medical Center, Houston, United States of America.
   Clinical Research Solution, Houston, United States of America.
   Baylor College of Medicine, Houston, United States of America.
   Texas A&M University, Corpus Christi, United States of America.
NR 0
TC 0
SN 1314-214
EI 
J9 Folia Med (Plovdiv)
PD JAN 9
PY 2021
VL 62
IS 4
BP 645
EP 654
DI 10.3897/folmed.62.e50705 
PG 9
WC Chronic Pain; complications; Global Health; Humans; Incidence; Quality of Life; Sleep; physiology; Sleep Initiation and Maintenance Disorders; epidemiology; Syndrome
UT PubMed:33415907
PM 33415907
DA 2021-01-09
ER

PT J
AU Hou, S
   Huh, B
   Kim, HK
   Kim, KH
   Abdi, S
AF Hou, Saiyun
   Huh, Billy
   Kim, Hee Kee
   Kim, Kyung-Hoon
   Abdi, Salahadin
TI Treatment of Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and 
SO Pain physician
LA English
DT Journal Article
AB BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a commonly 
   encountered disease entity following chemotherapy for cancer treatment. Although 
   only duloxetine is recommended by the American Society of Clinical Oncology 
   (ASCO) for the treatment of CIPN in 2014, the evidence of the clinical outcome 
   for new pharmaceutic therapies and non-pharmaceutic treatments has not been 
   clearly determined. OBJECTIVE: To provide a comprehensive review and 
   evidence-based recommendations on the treatment of CIPN. STUDY DESIGN: A 
   systematic review of each treatment regimen in patients with CIPN. METHODS: The 
   literature on the treatment of CIPN published from 1990 to 2017 was searched and 
   reviewed. The 2011 American Academy of Neurology Clinical Practice Guidelines 
   Process Manual was used to grade the evidence and risk of bias. We reviewed and 
   updated the recommendations of the ASCO in 2014, and evaluated new approaches for 
   treating CIPN. RESULTS: A total of 26 treatment options in 35 studies were 
   identified. Among these, 7 successful RCTs, 6 failed RCTs, 18 prospective 
   studies, and 4 retrospective studies were included. The included studies examined 
   not only pharmacologic therapy but also other modalities, including laser 
   therapy, scrambler therapy, magnetic field therapy and acupuncture, etc. Most of 
   the included studies had small sample sizes, and short follow-up periods. Primary 
   outcome measures were highly variable across the included studies. No studies 
   were prematurely closed owing to its adverse effects. LIMITATIONS: The 
   limitations of this systematic review included relatively poor homogeneous, with 
   variations in timing of treatment, primary outcomes, and chemotherapeutic agents 
   used. CONCLUSION: The evidence is considered of moderate benefit for duloxetine. 
   Photobiomodulation, known as low level laser therapy, is considered of moderate 
   benefit based on the evidence review. Evidence did not support the use of 
   lamotrigine and topical KA (4% ketamine and 2% amitriptyline). The evidence for 
   tricyclic antidepressants was inconclusive as amitriptyline showed no benefit but 
   nortriptyline had insufficient evidence. Further research on CIPN treatment is 
   needed with larger sample sizes, long-term follow-up, standardized outcome 
   measurements, and standardized treatment timing. KEY WORDS: Chemotherapy-induced 
   neuropathy, peripheral neuropathy, chemotherapy-tumor, neuropathic pain, chronic 
   pain, toxicology, treatment, reduction of pain, level of evidence.
C1 Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Department of Pain Medicine, Division of Anesthesia and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
   University of Texas, MD Anderson Cancer Center, Houston, TX.
NR 0
TC 0
SN 2150-114
EI 
J9 Pain Physician
PD DEC 5
PY 2018
VL 21
IS 6
BP 571
EP 592
DI 
PG 21
WC Adult; Antineoplastic Agents; adverse effects; Humans; Neuralgia; chemically induced; Pain Management; methods; Peripheral Nervous System Diseases; chemically induced; Prospective Studies; Retrospective Studies
UT PubMed:30508986
PM 30508986
DA 2018-12-05
ER

PT J
AU Szymoniuk, M
   Chin, JH
   Domagalski, Ł
   Biszewski, M
   Jóźwik, K
   Kamieniak, P
AF Szymoniuk, Michał
   Chin, Jia-Hsuan
   Domagalski, Łukasz
   Biszewski, Mateusz
   Jóźwik, Katarzyna
   Kamieniak, Piotr
TI Brain stimulation for chronic pain management: a narrative review of analgesic 
SO Neurosurgical review
LA English
DT Review
DE Chronic pain; Deep brain stimulation; Motor cortex stimulation; Non-invasive brain stimulation; Treatment
AB Chronic pain constitutes one of the most common chronic complaints that people 
   experience. According to the International Association for the Study of Pain, 
   chronic pain is defined as pain that persists or recurs longer than 3 months. 
   Chronic pain has a significant impact on individuals' well-being and psychosocial 
   health and the economy of healthcare systems as well. Despite the availability of 
   numerous therapeutic modalities, treatment of chronic pain can be challenging. 
   Only about 30% of individuals with non-cancer chronic pain achieve improvement 
   from standard pharmacological treatment. Therefore, numerous therapeutic 
   approaches were proposed as a potential treatment for chronic pain including 
   non-opioid pharmacological agents, nerve blocks, acupuncture, cannabidiol, stem 
   cells, exosomes, and neurostimulation techniques. Although some neurostimulation 
   methods such as spinal cord stimulation were successfully introduced into 
   clinical practice as a therapy for chronic pain, the current evidence for brain 
   stimulation efficacy in the treatment of chronic pain remains unclear. Hence, 
   this narrative literature review aimed to give an up-to-date overview of brain 
   stimulation methods, including deep brain stimulation, motor cortex stimulation, 
   transcranial direct current stimulation, repetitive transcranial magnetic 
   stimulation, cranial electrotherapy stimulation, and reduced impedance 
   non-invasive cortical electrostimulation as a potential treatment for chronic 
   pain.
C1 Student Scientific Association at the Department of Neurosurgery, Medical University of Lublin, Lublin, Poland.
   Student Scientific Association at the Department of Neurosurgery, Medical University of Lublin, Lublin, Poland.
   Student Scientific Association at the Department of Neurosurgery, Medical University of Lublin, Lublin, Poland. lukdom4@gmail.com.
   Student Scientific Association at the Department of Neurosurgery, Medical University of Lublin, Lublin, Poland.
   Student Scientific Association at the Department of Neurosurgery, Medical University of Lublin, Lublin, Poland.
   Department of Neurosurgery, Medical University of Lublin, Lublin, Poland.
NR 0
TC 0
SN 1437-232
EI 0344-560
J9 Neurosurg Rev
PD MAY 29
PY 2023
VL 46
IS 1
BP 127
EP 127
DI 10.1007/s10143-023-02032-1 
PG 0
WC Humans; Analgesics; Brain; Chronic Pain; therapy; Electric Stimulation Therapy; methods; Transcranial Direct Current Stimulation; methods; Transcranial Magnetic Stimulation; methods
UT PubMed:37247036
PM 37247036
DA 2023-05-29
ER

PT J
AU Luna, AL
   González, JA
   Guardo, LL
   Pájaro, Castro N
AF Luna, Alma Luz
   González, Jaime Andrés
   Guardo, Linda Lucía
   Pájaro Castro, Nerlis
TI CyberKnife Radiosurgery for refractory bilateral trigeminal neuralgia. Case 
SO Colombia medica (Cali, Colombia)
LA English
DT Journal Article
DE Radiosurgery; intractable pain; microsurgery; microvascular decompression surgery; rhizotomy; robotic surgical procedures; trigeminal neuralgia
AB Case description: A case of a 37-year-old female patient suffering from 
   refractory bilateral trigeminal neuralgia is presented, who underwent various 
   interventions such as acupuncture, block therapies and even microvascular 
   decompression without effective pain relief. CLINICAL FINDINGS: Paresthesias and 
   shooting-like twinges of pain intensity 10/10 in bilateral maxillary and 
   mandibular branches of the trigeminal nerve, with nasal and intraoral triggers 
   that made eating impossible, becoming increasingly severe since refractoriness to 
   microvascular decompression and carbamazepines, triggering the twinges even 
   during sleep, generating somnolence, depressive mood and social isolation. 
   TREATMENT AND RESULTS: The patient was evaluated by an interdisciplinary 
   neuro-oncology team, where, in accordance with the analysis of the brain magnetic 
   resonance imaging and the patient's history, it was indicated to perform 
   Cyberknife® radiosurgery in monofraction on the left trigeminal and subsequently 
   treat the contralateral trigeminal. When treated with Cyberknife® radiosurgery, 
   the patient reported absolute improvement in her pain for 2 years. CLINICAL 
   RELEVANCE: Radiosurgery by CyberKnife is not yet the first line of management in 
   trigeminal neuralgia, however, it should be considered since several studies have 
   managed to demonstrate an increase in the quality of life of patients and pain 
   relief in refractory or severe cases. of said pathology.
C1 Universidad de Sucre, Facultad Ciencias de la Salud, Grupo de Ciencias Médicas y Farmacéuticas. Sincelejo, Colombia.
   Clínica Las Peñitas, Sincelejo, Colombia.
   Universidad de Sucre, Facultad Ciencias de la Salud, Grupo de Ciencias Médicas y Farmacéuticas. Sincelejo, Colombia.
   Clínica Santa María, Sincelejo, Colombia.
   Universidad de Sucre, Facultad Ciencias de la Salud, Grupo de Ciencias Médicas y Farmacéuticas. Sincelejo, Colombia.
   Clínica FOSCAL Internacional, Floridablanca, Colombia.
   Universidad de Sucre, Facultad Ciencias de la Salud, Grupo de Ciencias Médicas y Farmacéuticas. Sincelejo, Colombia.
NR 0
TC 0
SN 1657-953
EI 0120-832
J9 Colomb Med (Cali)
PD JUN 8
PY 2023
VL 53
IS 4
BP e5005283
EP e5005283
DI 10.25100/cm.v53i4.5283 
PG 1
WC Female; Humans; Adult; Trigeminal Neuralgia; surgery; Treatment Outcome; Radiosurgery; methods; Quality of Life; Pain
UT PubMed:37287585
PM 37287585
DA 2023-06-08
ER

PT J
AU Chen, W
   Li, HC
   Wan, HY
   Liu, YH
   Jing, XH
   Zhang, XN
   He, W
AF Chen, Wei
   Li, Heng-Cong
   Wan, Hong-Ye
   Liu, Yi-Han
   Jing, Xiang-Hong
   Zhang, Xiao-Ning
   He, Wei
TI [Effect of electroacupuncture on spontaneous pain during the synovial 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE electroacupuncture; interleukin-6 (IL-6); knee osteoarthritis; saphenous nerve; synovitis; tumor necrosis factor-α (TNF-α)
AB OBJECTIVE: To observe the effect of electroacupuncture (EA) on pain behavior, 
   synovial inflammatory response and demyelination of saphenous nerve in the rats 
   modeled with knee osteoarthritis (KOA) and explore the effect mechanism of EA for 
   reliving allodynia. METHODS: Eighty-four male SD rats were randomly divided into 
   a control group, a model group and an EA group, 28 rats in each one. 
   Intra-articular injection of sodium monoiodoacetate (MIA) was administered in 
   right knee joint of each rat in the model group and the EA group to establish the 
   KOA model. In the EA group, separately, on day 5, 7 and 9 after modeling, EA was 
   applied at "Zusanli" (ST 36) and "Yanglingquan" (GB 34) on the right side, with 
   disperse-dense wave (2 Hz/15 Hz), 1 mA in current intensity, for 30 min in one 
   intervention, once a day, and 3 interventions were required. On the 9th day after 
   modeling, the weight-bearing rate was calculated for the affected limbs of the 
   rats in each group, the synovial morphological changes were observed using HE and 
   Masson staining, flow cytometry was adopted to detect the synovial immunocyte 
   counts, and MSD multi-spot assay was used to detected the synovial inflammatory 
   cytokine content. On the 14th day after modeling, the hind-paw mechanical 
   withdrawal threshold was observed in each group and the ultrastructure of the 
   saphenous nerve was observed under transmission electron microscopy. RESULTS: On 
   the 9th day after modeling, compared with the control group, the weight-bearing 
   rate of the affected limb was reduced (P<0.01), the synovial hyperplasia, 
   inflammatory cell infiltration and synovial fibrosis occurred in the affected 
   limb; the counts of synovial CD11b(+) cells and M1 macrophages (CD11b(+)CD86(+)) 
   were increased (P<0.01), the contents of tumor necrosis factor-α (TNF-α), 
   interleukin (IL)-6, IL-1β, IL-10 and IL-13 in the synovial tissue were elevated 
   (P<0.01, P<0.05) for the rats of the model group. Compared with the model group, 
   the weight-bearing rate of the affected limb was increased (P<0.05), the synovial 
   hyperplasia, inflammatory cell infiltration and synovial fibrosis were mitigated, 
   the counts of CD11b(+) cells and M1 macrophages (CD11b(+)CD86(+)) in the synovial 
   tissue, and the contents of TNF-α and IL-6 were reduced (P<0.01, P<0.05) in the 
   EA group. On the 14th day after modeling, the hind-paw mechanical withdrawal 
   threshold was reduced in the model group when compared with the control group 
   (P<0.01), and it was increased in the EA group when compared with the model group 
   (P<0.05). Besides, in the model group, obviously, the myelin sheath structure was 
   destroyed, the myelin layer was disintegrated and loosened, the axon was extruded 
   or the layer thicken and cracked. Compared with the model group, the injury of 
   saphenous nerve was alleviated remarkably in the EA group. CONCLUSION: The 
   intervention with EA may attenuate the synovial inflammatory response and the 
   injury of saphenous nerve in the affected limb of the rat with KOA, so that the 
   spontaneous pain during the synovial inflammatory response stage and allodynia at 
   the later stage are relieved.
C1 Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD DEC 10
PY 2022
VL 42
IS 12
BP 1385
EP 93
DI 10.13703/j.0255-2930.20220526-k0006 
PG -1292
WC Male; Rats; Animals; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Hyperplasia; Cytokines; Pain; etiology
UT PubMed:36484192
PM 36484192
DA 2022-12-10
ER

PT J
AU Machi, A
   Patel, A
   Ottestad, E
AF Machi, Anthony
   Patel, Ankur
   Ottestad, Einar
TI Nerve stimulation and neuromodulation for painful nerves: a narrative review.
SO International orthopaedics
LA English
DT Review
DE Axon regeneration; Neuromodulation; Neuropathic pain; Percutaneous electrical nerve stimulation; Peripheral nerve stimulation; Transcutaneous electrical nerve stimulation
AB Nerve injury primarily leads to neuropathic pain but may also have overlapping 
   elements of nociplastic pain or ongoing nociceptive pain. Electrical stimulation 
   is particularly effective in the treatment of neuropathic pain and may be 
   effective for nociplastic and nociceptive pain. While multiple mechanisms 
   contribute to the analgesic effect of electrical stimulation, the most widely 
   accepted theory for the predominant effect is that of Melzack and Wall's gate 
   control theory. According to this theory, non-painful sensory input carried by 
   low-threshold large-diameter Aβ fibres disrupt the transmission of pain signals 
   in small pain fibers (Aδ and C fibres). This occurs through the activation of 
   inhibitory interneurons in the dorsal horn, which ultimately blocks pain signal 
   transmission.This theory has been employed for different forms of stimulation, 
   including transcutaneous electrical nerve stimulation (TENS), percutaneous 
   electrical nerve stimulation (PENS), and peripheral nerve stimulation (PNS). Each 
   of these methods offers a different approach to localized stimulation and 
   neuromodulation for the treatment of pain. TENS is a non-invasive technique, that 
   delivers electrical currents via surface electrodes placed on the skin. PENS, in 
   contrast, is a minimally invasive method that applies electrical currents through 
   small needles inserted near a target muscle or neural structure. PNS involves the 
   implantation of temporary or permanent electrodes to deliver electrical 
   stimulation directly to peripheral nerves. These modalities are widely used to 
   manage various pain conditions including non-malignant, chronic musculoskeletal 
   and neuropathic pain, such as chronic low back pain, neck pain, neuropathic pain, 
   myofascial pain, and post-operative pain. TENS is particularly notable as a 
   non-invasive device that is affordable, over-the-counter, self-administered, and 
   nonpharmacological option that does not pose the risk of toxicity or overdose. 
   PENS stands out for its ability to integrate electrical stimulation therapy with 
   electroacupuncture through a minimally invasive technique. PNS, on the other 
   hand, is unique in its capacity to precisely target specific nerves and provide a 
   range of stimulation options for extended treatment durations.This article 
   provides a narrative overview of TENS, PENS and PNS with a particular focus on 
   their application for neuropathic pain management and for athletes. We will 
   review mechanisms of action, indications, diagnostic and treatment algorithms, as 
   well as complications and limitations. The overview concludes with a complex case 
   study demonstrating the use of various electrical stimulation therapies, 
   ultimately to successful pain resolution for the patient.
C1 Stanford University, Stanford, USA. amachi@stanford.edu.
   Novant Health Spine Specialists, Winston Salem, USA.
   Stanford University, Stanford, USA.
NR 0
TC 0
SN 1432-519
EI 
J9 Int Orthop
PD MAR 20
PY 2025
VL 49
IS 5
BP 989
EP 996
DI 10.1007/s00264-025-06498-0 
PG 7
WC Humans; Neuralgia; therapy; Transcutaneous Electric Nerve Stimulation; methods; Electric Stimulation Therapy; methods; Pain Management; methods
UT PubMed:40111452
PM 40111452
DA 2025-03-20
ER

PT J
AU Zhang, Q
   Yuan, Y
   Zhang, M
   Qiao, B
   Cui, Y
   Wang, Y
   Feng, L
AF Zhang, Qinglin
   Yuan, Yuntong
   Zhang, Meiling
   Qiao, Baohua
   Cui, Yiyuan
   Wang, Ying
   Feng, Li
TI Efficacy and safety of acupuncture-point stimulation combined with opioids for 
SO Frontiers in oncology
LA English
DT Journal Article
DE acupuncture-point stimulation; cancer pain; network meta-analysis; opioid; supplementary alternative therapy
AB BACKGROUND: Pain is one of the most common and troublesome symptoms of cancer. 
   Although potential positive effects of acupuncture-point stimulation (APS) on 
   cancer pain have been observed, knowledge regarding the selection of the optimal 
   APS remains unclear because of a lack of evidence from head-to-head randomized 
   controlled trials (RCTs). OBJECTIVE: This study aimed to carry out a network 
   meta-analysis to compare the efficacy and safety of different APS combined with 
   opioids in treating moderate to severe cancer pain and rank these methods for 
   practical consideration. METHODS: A comprehensive search of eight electronic 
   databases was conducted to obtain RCTs involving different APS combined with 
   opioids for moderate to severe cancer pain. Data were screened and extracted 
   independently using predesigned forms. The quality of RCTs was appraised with the 
   Cochrane Collaboration risk-of-bias tool. The primary outcome was the total pain 
   relief rate. Secondary outcomes were the total incidence of adverse reactions, 
   the incidence of nausea and vomiting, and the incidence of constipation. We 
   applied a frequentist, fixed-effect network meta-analysis model to pool effect 
   sizes across trials using rate ratios (RR) with their 95% confidence intervals 
   (CI). Network meta-analysis was performed using Stata/SE 16.0. RESULTS: We 
   included 48 RCTs, which consisted of 4,026 patients, and investigated nine 
   interventions. A network meta-analysis showed that a combination of APS and 
   opioids was superior in relieving moderate to severe cancer pain and reducing the 
   incidence of adverse reactions such as nausea, vomiting, and constipation 
   compared to opioids alone. The ranking of total pain relief rates was as follows: 
   fire needle (surface under the cumulative ranking curve (SUCRA) = 91.1%), body 
   acupuncture (SUCRA = 85.0%), point embedding (SUCRA = 67.7%), auricular 
   acupuncture (SUCRA = 53.8%), moxibustion (SUCRA = 41.9%), transcutaneous 
   electrical acupoint stimulation (TEAS) (SUCRA = 39.0%), electroacupuncture (SUCRA 
   = 37.4%), and wrist-ankle acupuncture (SUCRA = 34.1%). The ranking of total 
   incidence of adverse reactions was as follows: auricular acupuncture (SUCRA = 
   23.3%), electroacupuncture (SUCRA = 25.1%), fire needle (SUCRA = 27.2%), point 
   embedding (SUCRA = 42.6%), moxibustion (SUCRA = 48.2%), body acupuncture (SUCRA = 
   49.8%), wrist-ankle acupuncture (SUCRA = 57.8%), TEAS (SUCRA = 76.3%), and 
   opioids alone (SUCRA = 99.7%). CONCLUSIONS: APS seemed to be effective in 
   relieving cancer pain and reducing opioid-related adverse reactions. Fire needle 
   combined with opioids may be a promising intervention to reduce moderate to 
   severe cancer pain as well as reduce opioid-related adverse reactions. However, 
   the evidence was not conclusive. More high-quality trials investigating the 
   stability of evidence levels of different interventions on cancer pain must be 
   conducted. SYSTEMATIC REVIEW REGISTRATION: 
   https://www.crd.york.ac.uk/PROSPERO/#searchadvanced, identifier CRD42022362054.
C1 Department of Oncology, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
   Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing, China.
   Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   Department of Oncology, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
   Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing, China.
   Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   National Cancer Center/National Clinical Research Center for Cancer/Cancer 
   National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD JUN 19
PY 2023
VL 13
IS 
BP 1166580
EP 1166580
DI 10.3389/fonc.2023.1166580 
PG 0
UT PubMed:37333815
PM 37333815
DA 2023-06-19
ER

PT J
AU Irman
   Helianthi, DR
AF Irman
   Helianthi, Dwi Rachma
TI The Roles of Battlefield Acupuncture and Electroacupuncture in a Patient with 
SO Medical acupuncture
LA English
DT Journal Article
DE acupuncture; battlefield acupuncture; cancer pain; electroacupuncture
AB Background: Pain is one of the most-frightening complications of cancer and 
   disrupts quality of life. Cancer-related pain can be caused by primary cancer 
   itself, metastases that occur, and interventions to treat cancer. Almost all 
   cancer-related pain is pain with moderate-to-severe intensity. Thus, 
   cancer-related pain management often involves administration of opioid 
   analgesics. However, administration of opioid analgesics can cause side-effects 
   that cause new problems for these patients. Several studies have shown that 
   acupuncture can reduce cancer-related pain and data show that acupuncture therapy 
   is safe and can provide clinically meaningful improvements when used in 
   conjunction with standard therapy. Case: A 72-year-old female patient had pain 
   throughout her body since 1 month prior to before being admitted to the hospital. 
   She was unable to sleep at night often cried because she was unable to stand the 
   pain. This was reduced by morphine 3 × /day. Because of the drug's side-effects, 
   she slept more often during the day, could not sleep at night, and was 
   constipated. She also had breakthrough pain, on an average of 2-3 × /day. She had 
   a history of malignancy in the pleura, liver, lungs, and cervix. There was an 
   increase in some tumor markers. Her baseline numeric rating scale (NRS) 
   assessment was 4 with an oral morphine slow-release tablet 3 × 15 mg/day. 
   Acupuncture therapy was performed at Battlefield Acupuncture points of the right 
   ear and body acupuncture points (LI 4, LI 11, ST 36, SP 6, and LR 3) was treated 
   with 3-Hz continuous-wave electroacupuncture for 30 minutes at each session. 
   During this therapy, there were reductions in pain (baseline NRS 4 became 2), 
   need for morphine, morphine side-effects, and frequency of breakthrough pain. 
   There were no significant side-effects due to acupuncture. Conclusions: 
   Acupuncture is an effective and safe therapeutic option for reducing cancer pain 
   with minimal side-effects. Acupuncture can enable a reduced need for narcotic 
   analgesics.
C1 Department of Medical Acupuncture, Faculty of Medicine Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia.
   Department of Medical Acupuncture, Faculty of Medicine Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD SEP 4
PY 2020
VL 32
IS 4
BP 234
EP 240
DI 10.1089/acu.2020.1423 
PG 6
UT PubMed:32879650
PM 32879650
DA 2020-09-04
ER

PT J
AU Wang, X
   Shen, Q
   Hu, X
   Yu, X
   Erasmus, SR
   Gong, L
   Liu, J
   Fan, W
   Liang, Y
AF Wang, Xiaoying
   Shen, Qiongying
   Hu, Xinyi
   Yu, Xiaoshuai
   Erasmus, Shannah Rose
   Gong, Liyan
   Liu, Jianhao
   Fan, Wei
   Liang, Yi
TI Efficacy and Safety of Acupuncture Combined with Conventional Drug Therapy for 
SO Journal of pain research
LA English
DT Review
DE acupuncture; cancer-induced bone pain; network meta-analysis; supplementary alternative therapy
AB BACKGROUND: Cancer-induced bone pain (CIBP) involves both nociceptive and 
   neuropathic components, causing significant suffering in cancer patients. 
   Acupuncture has shown beneficial effects on CIBP. However, given the diverse 
   acupuncture techniques, their therapeutic efficacy may vary. OBJECTIVE: To 
   evaluate the efficacy and safety of various acupuncture modalities integrated 
   with conventional drug therapy for CIBP. METHODS: Randomized controlled trials 
   (RCTs) of acupuncture combined with conventional analgesics for CIBP were 
   searched across eight Chinese and English databases and clinical trial registries 
   up to September 2024. Two researchers independently performed literature 
   screening, data extraction, and bias assessment. Data were analyzed using Stata 
   14.0 and R 4.2.3. RESULTS: Twenty-two RCTs involving 1,738 patients were 
   included, assessing techniques including manual acupuncture (MA), 
   electroacupuncture (EA), moxibustion (MOX), acupoint injection (AI), acupoint 
   catgut embedding (ACE), auricular-plaster therapy (AP), thumbtack needle (TN) and 
   transcutaneous electrical acupoint stimulation (TEAS). The outcomes were assessed 
   across 20 studies for the clinical effective rate, 13 for nausea and vomiting, 
   and 11 for constipation.The results indicated that for the primary outcome of 
   pain relief (as measured by clinical effective rate), TN demonstrated the highest 
   probability of being the most effective acupuncture technique (SUCRA = 75.2%). In 
   terms of mitigating opioid-induced adverse reactions, ACE was most effective for 
   reducing nausea and vomiting (SUCRA = 87.7%), while EA+AP was optimal for 
   alleviating constipation (SUCRA = 93.5%). MA+MOX achieved the best overall 
   balance between efficacy and the incidence of adverse reactions. CONCLUSION: 
   Acupuncture combined with conventional drug therapy significantly improves pain 
   relief in CIBP and reduces opioid-related side effects. However, due to 
   methodological limitations and the modest sample sizes of available studies, 
   further high-quality, multicenter trials with larger samples are needed to 
   confirm these findings and inform clinical practice.
C1 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China.
   Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, People's Republic of China.
   Sanya Traditional Chinese Medicine Hospital, Sanya, Hainan Province, People's Republic of China.
   Sanya Traditional Chinese Medicine Hospital, Sanya, Hainan Province, People's Republic of China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China.
   The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD DEC 24
PY 2025
VL 18
IS 
BP 6807
EP 6826
DI 10.2147/JPR.S550454 
PG 19
UT PubMed:41438386
PM 41438386
DA 2025-12-24
ER

PT J
AU Atreya, CE
   Leach, H
   Asiimwe, E
   Bahri, N
   Le, BK
   Macaire, G
   Wood, KC
   Van, Blarigan EL
   Lee, RT
AF Atreya, Chloe E
   Leach, Heather
   Asiimwe, Edgar
   Bahri, Natasha
   Le, Bryan Khuong
   Macaire, Greta
   Wood, Kelley C
   Van Blarigan, Erin L
   Lee, Richard T
TI Integrative Oncology: Incorporating Evidence-Based Approaches for Patients With 
SO American Society of Clinical Oncology educational book. American Society of 
LA English
DT Review
AB Data have matured to support incorporation of integrative oncology modalities 
   into comprehensive cancer care. Clinical practice guidelines have recently been 
   published by ASCO for diet and exercise (2022) and use of cannabinoids and 
   cannabis (2024) and jointly by ASCO and the Society for Integrative Oncology 
   (SIO) for application of integrative approaches in the management of pain (2022), 
   anxiety and depression (2023), and fatigue (2024) among adults with cancer. 
   Following the ASCO-SIO guidelines, clinicians should recommend mindfulness-based 
   interventions (MBIs) to patients with symptoms of anxiety or depression and MBIs 
   and exercise for management of fatigue during or after completion of cancer 
   treatment. We will review the basis of these recommendations and evidence to 
   support use of other mind-body approaches, exercise, nutrition, 
   acupuncture/acupressure, and natural products in the specific contexts of GI 
   cancers. For example, optimizing physical activity and diet is associated with 
   improved survival after a colorectal cancer (CRC) diagnosis, in addition to 
   conferring symptom management benefits. We will also highlight gaps in research, 
   including that most studies enrolling patients with GI malignancies have focused 
   on CRC. A limitation of nonpharmacologic evidence-based guidelines is that they 
   list broad categories (eg, yoga or acupuncture) and lack implementation details. 
   How to safely and equitably incorporate integrative approaches into conventional 
   cancer care will be addressed. This ASCO Educational Book article aims to be both 
   evidence-informed and practical, with attention to unique considerations for 
   people with GI cancers.
C1 Department of Medicine, University of California, San Francisco, CA.
   Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.
   Osher Center for Integrative Health, San Francisco, CA.
   Department of Health and Exercise Science, Colorado State University, Fort Collins, CO.
   Department of Medicine, University of California, San Francisco, CA.
   National Clinician Scholars Program, University of California, San Francisco, CA.
   City of Hope National Medical Center, Duarte, CA.
   Department of Medicine, University of California, San Francisco, CA.
   Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.
   Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.
   ReVital Cancer Rehabilitation, Select Medical, Mechanicsburg, PA.
   Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.
   Department of Epidemiology and Biostatistics, University of California, San 
   Department of Urology, University of California, San Francisco, CA.
   City of Hope National Medical Center, Duarte, CA.
NR 0
TC 0
SN 1548-875
EI 
J9 Am Soc Clin Oncol Educ Book
PD JAN 22
PY 2025
VL 45
IS 1
BP e471734
EP e471734
DI 10.1200/EDBK-25-471734 
PG 1
WC Humans; Integrative Oncology; methods; Gastrointestinal Neoplasms; therapy; Evidence-Based Medicine
UT PubMed:39841946
PM 39841946
DA 2025-01-22
ER

PT J
AU Casazza, BA
AF Casazza, Brian A
TI Diagnosis and treatment of acute low back pain.
SO American family physician
LA English
DT Review
AB Acute low back pain is one of the most common reasons for adults to see a family 
   physician. Although most patients recover quickly with minimal treatment, proper 
   evaluation is imperative to identify rare cases of serious underlying pathology. 
   Certain red flags should prompt aggressive treatment or referral to a spine 
   specialist, whereas others are less concerning. Serious red flags include 
   significant trauma related to age (i.e., injury related to a fall from a height 
   or motor vehicle crash in a young patient, or from a minor fall or heavy lifting 
   in a patient with osteoporosis or possible osteoporosis), major or progressive 
   motor or sensory deficit, new-onset bowel or bladder incontinence or urinary 
   retention, loss of anal sphincter tone, saddle anesthesia, history of cancer 
   metastatic to bone, and suspected spinal infection. Without clinical signs of 
   serious pathology, diagnostic imaging and laboratory testing often are not 
   required. Although there are numerous treatments for nonspecific acute low back 
   pain, most have little evidence of benefit. Patient education and medications 
   such as nonsteroidal anti-inflammatory drugs, acetaminophen, and muscle relaxants 
   are beneficial. Bed rest should be avoided if possible. Exercises directed by a 
   physical therapist, such as the McKenzie method and spine stabilization 
   exercises, may decrease recurrent pain and need for health care services. Spinal 
   manipulation and chiropractic techniques are no more effective than established 
   medical treatments, and adding them to established treatments does not improve 
   outcomes. No substantial benefit has been shown with oral steroids, acupuncture, 
   massage, traction, lumbar supports, or regular exercise programs.
C1 University of North Carolina School of Medicine, Chapel Hill, NC, USA. brian_casazza@med.unc.edu
NR 0
TC 0
SN 1532-065
EI 
J9 Am Fam Physician
PD FEB 18
PY 2012
VL 85
IS 4
BP 343
EP 50
DI 
PG -293
WC Acute Disease; Analgesics, Opioid; therapeutic use; Anti-Inflammatory Agents, Non-Steroidal; therapeutic use; Exercise Therapy; Humans; Low Back Pain; diagnosis; Muscle Relaxants, Central; therapeutic use; Patient Education as Topic; Physical Examination
UT PubMed:22335313
PM 22335313
DA 2012-02-18
ER

PT J
AU Sun, DP
   Fu, J
   Teng, J
   Huang, Q
   Zhang, CD
   Gao, XZ
AF Sun, Dun-Po
   Fu, Jie
   Teng, Juan
   Huang, Qian
   Zhang, Chuan-Dong
   Gao, Xu-Zhu
TI [Cervical spondylosis of nerve root type with qi stagnation and blood stasis 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE acupuncture; inflammatory factors; nerve root type cervical spondylosis, qi stagnation and blood stasis; neurological function; warming needle
AB OBJECTIVE: To compare the clinical efficacy on cervical spondylosis of nerve root 
   type with qi stagnation and blood stasis treated with warming needle with 
   different lengths of moxa stick. METHODS: Six hundred patients with cervical 
   spondylosis of nerve root type with qi stagnation and blood stasis were randomly 
   divided into 4 groups: a 4 cm length group (150 cases, 5 cases dropped off, 2 
   cases suspended), a 3 cm length group (150 cases, 6 cases dropped off, 2 cases 
   suspended), a 2 cm length group (150 cases, 6 cases dropped off), and a routine 
   acupuncture group (150 cases, 6 cases dropped off). Warming needle with moxa 
   stick in the length of 4 cm, 3 cm and 2 cm was delivered in the 4 cm length 
   group, the 3 cm length group and the 2 cm length group, respectively. In the 
   routine acupuncture group, simple acupuncture was applied. The acupoints selected 
   in the above groups included Dazhui (GV 14) and bilateral Jiaji (EX-B 2) of C(5) 
   and C(7), Fengchi (GB 20), Jianzhen (SI 9), Quchi (LI 11), Zhongzhu (TE 3), etc. 
   In each group, the intervention was delivered once daily and 5 times a week. One 
   course of intervention was composed of 2 weeks and 2 courses were required. The 
   TCM syndrome score, the score of clinical assessment scale for cervical 
   spondylosis (CASCS), the score of the brachial plexus traction test of the 
   affected upper limb, F wave occurrence rate and conduction velocity of the ulnar 
   nerve, the median nerve and the radial nerve of the affected upper limb were 
   compared before and after treatment in the patients of each group. The levels of 
   serum inflammatory factors, i.e. interleukin-1β (IL-1β), interleukin-6 (IL-6), 
   tumor necrosis factor α (TNF-α) and hypersensitive C-reactive protein (hs-CRP), 
   were measured before and after treatment in the patients of each group. The 
   clinical cfficacy was evaluated in the 4 groups. RESULTS: After treatment, the 
   results of TCM syndrome evaluation, i.e. the scores of neck pain, activity 
   limitation and upper limb numbness and pain, as well as the total scores; and the 
   scores of brachial plexus traction test were reduced when compared with those 
   before treatment in each group (P<0.01, P<0.05). The scores of subjective 
   symptoms and adaptability, and the total scores of CASCS were elevated in 
   comparison with those before treatment in each group (P<0.01, P<0.05). In the 4 
   cm length group, compared with the other 3 groups, the scores of neck pain and 
   activity limitation for TCM syndrome evaluation, and its total score were lower 
   (P<0.05, P<0.01); and the scores of subjective symptoms and adaptability, and the 
   total score of CASCS were higher (P<0.05, P<0.01). The score of the brachial 
   plexus traction test in the 4 cm length group was lower than that of the routine 
   acupuncture group (P<0.05). After treatment, F wave occurrence rates and 
   conduction velocity of median nerve and radial nerve were increased when compared 
   with those before treatment in each group (P<0.05, P<0.01). F wave occurrence 
   rate and conduction velocity of the radial nerve in the 4 cm length group were 
   higher than those of the other 3 groups (P<0.05), and those of the median nerve 
   were higher when compared with the routine acupuncture group (P<0.05). After 
   treatment, the levels of serum IL-1β, IL-6 and TNF-α were all reduced when 
   compared with those before treatment in each group (P<0.01, P<0.05); the level of 
   serum IL-6 in the 4 cm length group was lower than those of the other 3 groups 
   and serum level of TNF-α was lower compared with that in the routine acupuncture 
   group (P<0.05). The total effective rate of the 4 cm length group was 78.3% 
   (112/143), which was higher when compared with the 3 cm length group (67.6%, 
   96/142), the 2 cm length group (65.3%, 94/144) and the routine acupuncture group 
   (53.5%, 77/144), respectively (P<0.05). CONCLUSION: Warming needle with moxa 
   stick of 4 cm in length effectively relieves the clinical symptoms of cervical 
   spondylosis of nerve root type with qi stagnation and blood stasis, improves the 
   nerve function of the upper limbs, and reduces the inflammatory responses caused 
   by nerve compression. The clinical efficacy of this therapy with moxa stick of 4 
   cm in length is superior to the warming needle with moxa sticks of 3 cm and 2 cm, 
   as well as the routine acupuncture.
C1 Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine/Lianyungang Hospital of TCM Affiliated to Kangda College of NanjingMedical University, Lianyungang 222004, Jiangsu Province, China.
   Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine/Lianyungang Hospital of TCM Affiliated to Kangda College of NanjingMedical University, Lianyungang 222004, Jiangsu Province, China.
   Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine/Lianyungang Hospital of TCM Affiliated to Kangda College of NanjingMedical University, Lianyungang 222004, Jiangsu Province, China.
   Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine/Lianyungang Hospital of TCM Affiliated to Kangda College of NanjingMedical University, Lianyungang 222004, Jiangsu Province, China.
   Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine/Lianyungang Hospital of TCM Affiliated to Kangda College of NanjingMedical University, Lianyungang 222004, Jiangsu Province, China.
   Central Laboratory of Lianyungang Second People's Hospital.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD JUN 14
PY 2023
VL 43
IS 6
BP 647
EP 53
DI 10.13703/j.0255-2930.20220810-k0003 
PG -594
WC Humans; Interleukin-6; Neck Pain; Qi; Tumor Necrosis Factor-alpha; Spondylosis; therapy
UT PubMed:37313558
PM 37313558
DA 2023-06-14
ER

PT J
AU Roostaei, G
   Khoshnam, Rad N
   Fakhri, B MS
   Nikfar, S
   Abdollahi, M
AF Roostaei, Ghazal
   Khoshnam Rad, Niloofar
   Fakhri B, Maryam S
   Nikfar, Shekoufeh
   Abdollahi, Mohammad
TI Emerging therapies for opioid-induced constipation: what can we expect?
SO Expert opinion on pharmacotherapy
LA English
DT Review
DE OIC; Opioid-induced constipation; PAMORAs; emerging therapies; expert opinion; expert review; peripherally acting mu-opioid receptor antagonists
AB INTRODUCTION: The rise in opioid use for managing chronic and oncologic pain has 
   led to a significant increase in opioid-induced constipation (OIC) that impacts 
   patient quality of life and pain management. AREAS COVERED: In this study, 
   emerging therapies for OIC were criticized for refining advancements and novel 
   treatment options. Key topics included the efficacy of peripherally acting 
   mu-opioid receptor antagonists (PAMORAs) such as methylnaltrexone, naloxegol, and 
   naldemedine, which specifically target opioid-induced gut dysfunction. Other 
   treatment options, including intestinal secretagogues like lubiprostone and 
   linaclotide, selective 5-HT receptor agonists such as prucalopride, and emerging 
   adjunctive therapies like transcutaneous electrical nerve stimulation (TENS) and 
   electroacupuncture were mentioned. Current guidelines from the American 
   Gastroenterological Association (AGA) and the European consensus were criticized. 
   EXPERT OPINION: Experts stress the importance of a stepwise approach to managing 
   OIC, considering patient-specific factors and the efficacy of various treatments. 
   While PAMORAs have demonstrated effectiveness in improving bowel function, their 
   high cost and lack of extensive head-to-head comparisons with traditional 
   laxatives are significant concerns. Emerging therapies and adjunctive treatments 
   offer promising results but require further validation through rigorous studies. 
   Future research should focus on long-term outcomes, cost-effectiveness, and 
   comparative effectiveness to better address the complex needs of patients with 
   OIC and refine treatment protocols.
C1 Department of Internal Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
   Thoracic Research Center, Imam Khomeini Hospital Complex, Tehran University of 
   Thoracic Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
   Faculty of Pharmacy and Pharmaceutical Sciences Research Center (PSRC), Tehran 
   Department of Internal Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
   Faculty of Pharmacy and Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
   Personalized Medicine Research Center, Endocrinology and Metabolism Research 
   Faculty of Pharmacy and Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
NR 0
TC 0
SN 1744-766
EI 
J9 Expert Opin Pharmacother
PD SEP 23
PY 2024
VL 25
IS 13
BP 1729
EP 1738
DI 10.1080/14656566.2024.2407013 
PG 9
WC Humans; Analgesics, Opioid; adverse effects; Narcotic Antagonists; therapeutic use; Opioid-Induced Constipation; drug therapy; Quality of Life; Receptors, Opioid, mu; antagonists & inhibitors; Laxatives; therapeutic use; Chronic Pain; drug therapy; Transcutaneous Electric Nerve Stimulation; methods; Practice Guidelines as Topic; Serotonin Receptor Agonists; therapeutic use; Constipation; chemically induced
UT PubMed:39308446
PM 39308446
DA 2024-09-23
ER

PT J
AU Ge, L
   Wang, Q
   He, Y
   Wu, D
   Zhou, Q
   Xu, N
   Yang, K
   Chen, Y
   Zhang, AL
   Hua, H
   Huang, J
   Hui, KK
   Liang, F
   Wang, L
   Xu, B
   Yang, Y
   Zhang, W
   Zhao, B
   Zhu, B
   Guo, X
   Xue, CC
   Zhang, H
AF Ge, Long
   Wang, Qi
   He, Yihan
   Wu, Darong
   Zhou, Qi
   Xu, Nenggui
   Yang, Kehu
   Chen, Yaolong
   Zhang, Anthony Lin
   Hua, Haiqing
   Huang, Jinchang
   Hui, Ka-Kit
   Liang, Fanrong
   Wang, Linpeng
   Xu, Bin
   Yang, Yufei
   Zhang, Weimin
   Zhao, Baixiao
   Zhu, Bing
   Guo, Xinfeng
   Xue, Charlie Changli
   Zhang, Haibo
TI Acupuncture for cancer pain: an evidence-based clinical practice guideline.
SO Chinese medicine
LA English
DT Review
DE Acupuncture; Cancer pain; Evidence-based practice; Practice guideline
AB BACKGROUND: This study aims to develop an evidence-based clinical practice 
   guideline of acupuncture in the treatment of patients with moderate and severe 
   cancer pain. METHODS: The development of this guideline was triggered by a 
   systematic review published in JAMA Oncology in 2020. We searched databases and 
   websites for evidence on patient preferences and values, and other resources of 
   using acupuncture for treatment of cancer pain. Recommendations were developed 
   through a Delphi consensus of an international multidisciplinary panel including 
   13 western medicine oncologists, Chinese medicine/acupuncture clinical 
   practitioners, and two patient representatives. The certainty of evidence, 
   patient preferences and values, resources, and other factors were fully 
   considered in formulating the recommendations. The Grading of Recommendations 
   Assessment, Development, and Evaluation (GRADE) approach was employed to rate the 
   certainty of evidence and the strength of recommendations. RESULTS: The guideline 
   proposed three recommendations: (1) a strong recommendation for the treatment of 
   acupuncture rather than no treatment to relieve pain in patients with moderate to 
   severe cancer pain; (2) a weak recommendation for the combination treatments with 
   acupuncture/acupressure to reduce pain intensity, decrease the opioid dose, and 
   alleviate opioid-related side effects in moderate to severe cancer pain patients 
   who are using analgesics; and (3) a strong recommendation for acupuncture in 
   breast cancer patients to relieve their aromatase inhibitor-induced arthralgia. 
   CONCLUSION: This proposed guideline provides recommendations for the management 
   of patients with cancer pain. The small sample sizes of evidence limit the 
   strength of the recommendations and highlights the need for additional research.
C1 Department of Social Medicine and Health Management, School of Public Health, Lanzhou University, Lanzhou, China.
   Evidence Based Social Science Research Centre, School of Public Health, Lanzhou 
   WHO Collaborating Center for Guideline Implementation and Knowledge Translation, Lanzhou, China.
   Chinese GRADE Centre, Lanzhou University, Lanzhou, China.
   Department of Social Medicine and Health Management, School of Public Health, Lanzhou University, Lanzhou, China.
   Evidence Based Social Science Research Centre, School of Public Health, Lanzhou 
   Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
   Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
   Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
   South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou,China.
   Evidence Based Social Science Research Centre, School of Public Health, Lanzhou University, Lanzhou, China.
   WHO Collaborating Center for Guideline Implementation and Knowledge Translation, 
   Chinese GRADE Centre, Lanzhou University, Lanzhou, China.
   Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu 
   WHO Collaborating Center for Guideline Implementation and Knowledge Translation, Lanzhou, China.
   Chinese GRADE Centre, Lanzhou University, Lanzhou, China.
   Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
   Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu 
   China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
   Oncology Department of Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing, China.
   The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China.
   Center for East-West Medicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Santa Monica, USA.
   Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
   Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, China.
   Department of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
   Department of Oncology, Southern Theater Command General Hospital of PLA, Guangzhou, China.
   School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
   Institute of Acupuncture and Moxibustion, China Academy of Chinese Medicine Sciences, Beijing, China.
   Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China. guoxinfeng@gzucm.edu.
   The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China. guoxinfeng@gzucm.edu.
   Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China. charlie.xue@rmit.edu.au.
   The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China. charlie.xue@rmit.edu.au.
   China-Australia International Research Centre for Chinese Medicine, School of 
   Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China. haibozh@gzucm.edu.cn.
   The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
   Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China. haibozh@gzucm.edu.cn.
NR 0
TC 0
SN 1749-854
EI 1749-854
J9 Chin Med
PD JAN 6
PY 2022
VL 17
IS 1
BP 8
EP 8
DI 10.1186/s13020-021-00558-4 
PG 0
UT PubMed:34983587
PM 34983587
DA 2022-01-06
ER

PT J
AU Wang, M
   Pei, Z
   Molassiotis, A
AF Wang, Mian
   Pei, Ziwen
   Molassiotis, Alex
TI Recent advances in managing chemotherapy-induced peripheral neuropathy: A 
SO European journal of oncology nursing : the official journal of European Oncology 
LA English
DT Journal Article
DE Cancer; Chemotherapy-induced peripheral neuropathy; Pain; Symptom management; Systematic review
AB PURPOSE: The aim in this review was to explore recent advances in 
   chemotherapy-induced peripheral neuropathy (CIPN) management interventions and to 
   identify the implications for practice and future research. METHODS: A 
   comprehensive search through seven electronic databases (AMED, CINAHL, Cochrane 
   Library, EMBASE, PEDro, PubMed, and Web of Science) was conducted for studies 
   published between January 1, 2013 and August 3, 2019. An updated search for 
   subsequently published studies was made through PubMed on February 15, 2022. 
   Randomized controlled trials (RCTs) involving either pharmacological or 
   non-pharmacological interventions were considered eligible. The Cochrane Risk of 
   Bias tool version 2.0 (RoB 2.0) was used to appraise the methodological risk of 
   bias. Data extracted from the included RCTs were synthesized in a narrative 
   approach. RESULTS: Forty-two RCTs involving a total of 3393 participants were 
   included. Overall, a high risk of bias was found in most of the included RCTs. 
   The results further confirmed the analgesic effect of duloxetine on pain-related 
   to CIPN. Exercise-based interventions, acupuncture, and several non-invasive 
   neuromodulation techniques showed promise for managing CIPN. CONCLUSIONS: The 
   effects of most pharmacological and non-pharmacological interventions on CIPN are 
   inconclusive due to methodological issues. Duloxetine remains the only 
   pharmacological intervention recommended for managing pain related to CIPN. 
   Although definitive recommendations cannot be made based on current research 
   evidence, non-pharmacological interventions, especially non-invasive 
   neuromodulation techniques, warrant future research.
C1 School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
   Department of Rehabilitation Medicine, Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, Hubei Province, China.
   School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China. 
EM alex.molasiotis@polyu.edu.hk
NR 0
TC 0
SN 1532-212
EI 
J9 Eur J Oncol Nurs
PD APR 15
PY 2022
VL 58
IS 
BP 102134
EP 102134
DI 10.1016/j.ejon.2022.102134 
PG 0
WC Antineoplastic Agents; adverse effects; Duloxetine Hydrochloride; therapeutic use; Humans; Pain; Pain Management; Peripheral Nervous System Diseases; chemically induced
UT PubMed:35421796
PM 35421796
DA 2022-04-15
ER

PT J
AU Han, QQ
   Fu, Y
   Le, JM
   Ma, YJ
   Wei, XD
   Ji, HL
   Jiang, H
   Gao, Y
   Wu, H
AF Han, Qiu-Qin
   Fu, Yi
   Le, Jia-Mei
   Ma, Yu-Jie
   Wei, Xin-Dong
   Ji, Hou-Lin
   Jiang, Haochen
   Gao, Yueqiu
   Wu, Hailong
TI The Therapeutic Effects of Acupuncture and Electroacupuncture on Cancer-related 
SO Journal of Cancer
LA English
DT Review
DE acupuncture; cancer; chemotherapy; electroacupuncture; pain; surgery
AB In addition to cancer-related death, malignant progression also leads to a series 
   of symptoms and side-effects, which would detrimentally affect cancer patients' 
   the quality of life, adversely influence their adherence to treatments, and, 
   therefore, negatively affect their long-term survival. Acupuncture and 
   electroacupuncture (EA), as two classic treatment methods in traditional Chinese 
   medicine, have been widely employed to cure various diseases. Recently, the 
   clinical application of acupuncture and EA in cancer patients has received great 
   attention. In this review, we summarized the clinical application of acupuncture 
   and EA in alleviating the cancer symptoms, reducing the cancer treatment-related 
   side-effects, and relieving the cancer pain. The symptoms and side-effects 
   discussed in this review include fatigue, insomnia, chemotherapy-associated 
   dyspepsia syndrome (CADS), pain, xerostomia, and anxiety and depression. The 
   underlying mechanisms of the therapeutic effects of acupuncture and EA might be 
   related to the regulation of the mitochondrial function, coordination of the 
   activity of the nervous system, adjustment of the production of 
   neurotransmitters, and alleviation of the immune responses. In conclusion, 
   acupuncture and EA have been proved to be beneficial for cancer patients. More 
   research, however, is required to clarify the potential mechanisms behind 
   acupuncture and EA for widespread adoption in clinical application.
C1 Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China.
   Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & 
   Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
   Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China.
   Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & 
   Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
   Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China.
   Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & 
   Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
   Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China.
   Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & 
   Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
   Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China.
   Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & 
   Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
   Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China.
   Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & 
   Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
   Institute of Clinical Immunology, Department of Liver Diseases, Central Laboratory, Shuguang Hospital Affiliated to Shanghai University of TraditionalChinese Medicine, Shanghai 200021, China.
   Laboratory of Cellular Immunity, Shuguang Hospital Affiliated to Shanghai 
   Institute of Clinical Immunology, Department of Liver Diseases, Central Laboratory, Shuguang Hospital Affiliated to Shanghai University of TraditionalChinese Medicine, Shanghai 200021, China.
   Laboratory of Cellular Immunity, Shuguang Hospital Affiliated to Shanghai 
   Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China.
   Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & 
   Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
NR 0
TC 0
SN 1837-966
EI 1837-966
J9 J Cancer
PD NOV 4
PY 2021
VL 12
IS 23
BP 7003
EP 7009
DI 10.7150/jca.55803 
PG 6
UT PubMed:34729102
PM 34729102
DA 2021-11-04
ER

PT J
AU Wang, F
   Zhao, J
   Li, Y
   Yang, X
   Wu, D
   Yang, B
   Zhang, C
   He, Z
   Du, L
   Zhu, X
   Ming, D
   Liu, Y
   Tang, D
AF Wang, Feiqing
   Zhao, Jianing
   Li, Yanju
   Yang, Xu
   Wu, Dan
   Yang, Bo
   Zhang, Chike
   He, Zhixu
   Du, Liang
   Zhu, Xiaodong
   Ming, Dong
   Liu, Yang
   Tang, Dongxin
TI Acupuncture and acupressure with improved cancer-related depression of 
SO Frontiers in oncology
LA English
DT Journal Article
DE acupoints; acupressure; acupuncture; cancer/tumor/oncology; depression
AB INTRODUCTION: Acupuncture and acupressure are widely used for treating cancer 
   pain and depression and recognized as safe and effective by the international 
   medical community. In this study, we systematically evaluated the efficacy, 
   safety, and clinical significance of acupuncture and acupressure in treating 
   cancer-related depression. METHODS: We searched MEDLINE, PubMed, Science Direct, 
   Google Scholar, Web of Science and Embase and Chinese-language databases for 
   randomized clinical trials (RCTs). To assess efficacy, rating scales administered 
   by clinicians or experts were preferred, including the Hamilton Depression Rating 
   Scale (HAMD), Self-rating Depression Scale (SDS), Self-rating Anxiety Scale 
   (SAS), and Quality of Life Questionnaire-Core 30 (QLQ-C30) and the total 
   effective rate after treatment. In all, Sixteen RCTs involving 1019 cancer 
   patients were included in the Meta-analysis. RESULTS: Eleven (69%) of these 
   studies reported the post-treatment total effective rate. Three hundred 
   fifty-three patients received antidepressants; the total effective rate was 
   72.5%. Three hundred sixty-one patients underwent acupuncture and acupressure; 
   the total effective rate was 90%. Meta-analysis results showed I(2) = 0%, no 
   heterogeneity, (Z = 5.84, p < 0.00001); and combined OR = 3.55, (95% CI = 2.32 to 
   5.43). DISCUSSION: This study found that acupuncture and acupressure are as 
   effective as medication in the treatment of cancer-related depression, provide a 
   reliable basis for the clinical use of acupuncture to treat cancer-related 
   depression, help promote nonpharmacological treatment for cancer-related 
   complications. These approaches thus help reduce drug resistance and adverse 
   reactions and improve patients' quality of life.
C1 Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
   Academy of Medical Engineering and Translational Medicine, Tianjin University, 
   Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
   Department of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
   Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
   Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
   Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
   Department of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
   Department of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
   Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of 
   Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
   Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
   Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 
   Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
   Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
   Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of 
   Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD DEC 30
PY 2022
VL 12
IS 
BP 1036634
EP 1036634
DI 10.3389/fonc.2022.1036634 
PG 0
UT PubMed:36578922
PM 36578922
DA 2022-12-30
ER

PT J
AU Greenlee, H
   DuPont-Reyes, MJ
   Balneaves, LG
   Carlson, LE
   Cohen, MR
   Deng, G
   Johnson, JA
   Mumber, M
   Seely, D
   Zick, SM
   Boyce, LM
   Tripathy, D
AF Greenlee, Heather
   DuPont-Reyes, Melissa J
   Balneaves, Lynda G
   Carlson, Linda E
   Cohen, Misha R
   Deng, Gary
   Johnson, Jillian A
   Mumber, Matthew
   Seely, Dugald
   Zick, Suzanna M
   Boyce, Lindsay M
   Tripathy, Debu
TI Clinical practice guidelines on the evidence-based use of integrative therapies 
SO CA: a cancer journal for clinicians
LA English
DT Journal Article
DE acupressure; acupuncture; breast cancer; complementary therapies; integrative medicine; integrative oncology; massage; meditation; music therapy; stress management; yoga
AB Answer questions and earn CME/CNE Patients with breast cancer commonly use 
   complementary and integrative therapies as supportive care during cancer 
   treatment and to manage treatment-related side effects. However, evidence 
   supporting the use of such therapies in the oncology setting is limited. This 
   report provides updated clinical practice guidelines from the Society for 
   Integrative Oncology on the use of integrative therapies for specific clinical 
   indications during and after breast cancer treatment, including anxiety/stress, 
   depression/mood disorders, fatigue, quality of life/physical functioning, 
   chemotherapy-induced nausea and vomiting, lymphedema, chemotherapy-induced 
   peripheral neuropathy, pain, and sleep disturbance. Clinical practice guidelines 
   are based on a systematic literature review from 1990 through 2015. Music 
   therapy, meditation, stress management, and yoga are recommended for 
   anxiety/stress reduction. Meditation, relaxation, yoga, massage, and music 
   therapy are recommended for depression/mood disorders. Meditation and yoga are 
   recommended to improve quality of life. Acupressure and acupuncture are 
   recommended for reducing chemotherapy-induced nausea and vomiting. 
   Acetyl-L-carnitine is not recommended to prevent chemotherapy-induced peripheral 
   neuropathy due to a possibility of harm. No strong evidence supports the use of 
   ingested dietary supplements to manage breast cancer treatment-related side 
   effects. In summary, there is a growing body of evidence supporting the use of 
   integrative therapies, especially mind-body therapies, as effective supportive 
   care strategies during breast cancer treatment. Many integrative practices, 
   however, remain understudied, with insufficient evidence to be definitively 
   recommended or avoided. CA Cancer J Clin 2017;67:194-232. © 2017 American Cancer 
   Society.
C1 Assistant Professor, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
   Member, Herbert Irving Comprehensive Cancer Center, Columbia University, New 
   Doctoral Fellow, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
   Associate Professor, College of Nursing, Rady Faculty of Health Sciences, Winnipeg, MB, Canada.
   Professor, Department of Oncology, University of Calgary, Calgary, AB, Canada.
   Adjunct Professor, American College of Traditional Chinese Medicine at California Institute of Integral Studies, San Francisco, CA.
   Clinic Director, Chicken Soup Chinese Medicine, San Francisco, CA.
   Medical Director, Integrative Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
   Post-Doctoral Scholar, Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA.
   Radiation Oncologist, Harbin Clinic, Rome, GA.
   Executive Director, Ottawa Integrative Cancer Center, Ottawa, ON, Canada.
   Executive Director of Research, Canadian College of Naturopathic Medicine, 
   Research Associate Professor, Department of Family Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI.
   Research Associate Professor, Department of Nutritional Sciences, School of 
   Research Informationist, Memorial Sloan Kettering Library, Memorial Sloan Kettering Cancer Center, New York, NY.
   Professor, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
NR 0
TC 0
SN 1542-486
EI 0007-923
J9 CA Cancer J Clin
PD APR 25
PY 2017
VL 67
IS 3
BP 194
EP 232
DI 10.3322/caac.21397 
PG 38
WC Anxiety; therapy; Breast Neoplasms; complications; Complementary Therapies; Depression; therapy; Fatigue; therapy; Female; Humans; Lymphedema; therapy; Mood Disorders; therapy; Nausea; therapy; Peripheral Nervous System Diseases; therapy; Quality of Life; Sleep Wake Disorders; therapy; Stress, Psychological; therapy; Vomiting; therapy
UT PubMed:28436999
PM 28436999
DA 2017-04-25
ER

PT J
AU Han, G
   Lee, YS
   Jang, HJ
   Kim, SY
   Lee, YJ
   Ha, IH
AF Han, Gajin
   Lee, Ye-Seul
   Jang, Hee Jae
   Kim, Song-Yi
   Lee, Yoon Jae
   Ha, In-Hyuk
TI Symptom Management and Quality of Life of Breast Cancer Patients Using 
SO Cancers
LA English
DT Journal Article
DE acupuncture; anticancer treatment; breast cancer; herbal medicine; scoping review; side effects
AB The side effects associated with breast cancer treatments often reduce the 
   patients' quality of life. The effectiveness of acupuncture-related therapies and 
   herbal medicine in managing the side effect is not fully understood. The study 
   included clinical studies published in the 10 years since 2011 and analyzed the 
   effectiveness of the therapies for managing side effects of anticancer treatment. 
   The databases of MEDLINE via PubMed, CENTRAL, EMBASE, OASIS, and NSDL were 
   searched. Thirty studies, including 13 (43.3%) randomized controlled trials 
   (RCTs), 12 (40.0%) before-and-after studies, three (10.0%) case series, one 
   (3.3%) case report, and one (3.3%) non-RCT, were included in this review. The 
   main symptoms identified were aromatase inhibitors-induced arthralgia (AIA), 
   lymphedema, and chemotherapy-induced peripheral neuropathy (CIPN). The types of 
   acupuncture-related therapies applied included manual acupuncture, 
   electro-acupuncture, moxibustion, and electro-moxibustion. In ten studies, eight 
   herbal medications were administered. The Brief Pain Inventory-Short Form 
   (BPI-SF) and Functional Assessment of Cancer Therapy-General (FACT-G) and -Breast 
   (FACT-B) were frequently used to evaluate pain and QoL, respectively. Most 
   studies suggested beneficial effects of acupuncture and herbal medicine on 
   managing pain, daily function, and quality of life in patients going through AIA, 
   CIPN, and/or lymphedema, with mild side effects. The scoping review implies the 
   potential of CAM therapies as promising interventions for managing symptoms which 
   otherwise lack alternative management options, and for improving the quality of 
   life of breast cancer patients.
C1 JINRESEARCH, Namyangju 12113, Korea.
   Kyung Hee Sweet & Sunny Korean Medicine Clinic, Namyangju 12113, Korea.
   Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul 06110, Korea.
   Kyung Hee Yakson Korean Medicine Clinic, Suwon 16393, Korea.
   Department of Anatomy and Acupoint, College of Korean Medicine, Gachon University, Seongnam 13120, Korea.
   Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul 06110, Korea.
   Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul 06110, Korea.
NR 0
TC 0
SN 2072-669
EI 2072-669
J9 Cancers (Basel)
PD OCT 15
PY 2022
VL 14
IS 19
BP 
EP 
DI 10.3390/cancers14194683 
PG 0
UT PubMed:36230606
PM 36230606
DA 2022-10-15
ER

PT J
AU Dupuis, LL
   Nathan, PC
AF Dupuis, L Lee
   Nathan, Paul C
TI Optimizing emetic control in children receiving antineoplastic therapy: beyond 
SO Paediatric drugs
LA English
DT Review
AB Existing guidelines for the prevention of antineoplastic chemotherapy-induced 
   nausea and vomiting (CINV) in children are constrained by the lack of robust 
   evidence. Current guidelines recommend the use of a serotonin 5-HT(3) receptor 
   antagonist plus a corticosteroid to prevent acute CINV. Consequently, antiemetic 
   agents that are recommended for use in adult cancer patients do not appear in the 
   current pediatric guidelines. In addition, there is no information to guide the 
   selection of alternative antiemetic agents for children who either cannot receive 
   the recommended agents or who do not respond adequately to the treatment. 
   Possible barriers to adherence to the pediatric antiemetic selection guidelines 
   that are currently available are discussed, and published pediatric experience 
   with antiemetic agents recommended in the current adult antiemetic selection 
   guidelines (dolasetron, tropisetron, palonosetron, aprepitant) is summarized in 
   this review. The use of novel and emerging antiemetic therapeutic interventions 
   {metopimazine, diphenhydramine (Benadryl)-lorazepam (Avitan)-dexamethasone 
   (Decadron) [BAD], nabilone, acupuncture, midazolam, olanzapine, mirtazapine, 
   gabapentin, droperidol} in children are explored.
C1 Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada. lee.dupuis@sickkids.ca
NR 0
TC 0
SN 1179-201
EI 
J9 Paediatr Drugs
PD DEC 26
PY 2009
VL 12
IS 1
BP 51
EP 61
DI 10.2165/11316190-000000000-00000 
PG 10
WC Acupuncture; Antiemetics; administration & dosage; Antineoplastic Agents; adverse effects; Cannabinoids; therapeutic use; Drug Combinations; Electrocardiography; drug effects; Glucocorticoids; therapeutic use; Guideline Adherence; Headache; chemically induced; Humans; Nausea; chemically induced; Neurokinin-1 Receptor Antagonists; Pediatrics; Practice Guidelines as Topic; Serotonin Antagonists; therapeutic use; Vomiting; chemically induced
UT PubMed:20034341
PM 20034341
DA 2009-12-26
ER

PT J
AU Li, C
   Zhao, C
   Zhao, J
   Wang, M
   Luo, F
   Zhou, J
AF Li, Chunyu
   Zhao, Can
   Zhao, Jingjing
   Wang, Min
   Luo, Furong
   Zhou, Jianwei
TI Global research trends of acupuncture therapy on cancer pain: A bibliometric and 
SO Frontiers in oncology
LA English
DT Journal Article
DE VOSviewer; acupuncture; bibliometric analysis; cancer pain; web of science
AB BACKGROUND: The number of publications on acupuncture for cancer pain is 
   increasing rapidly with an upward tendency. Considering that no bibliometric 
   articles related to this topic have been published yet. It is necessary to 
   evaluate the global scientific output of research in this field, and shed light 
   on the direction of clinical cancer pain management in the future. METHODS: 
   Research publications regarding acupuncture on cancer pain from inception to 2022 
   were downloaded from the Web of Science Core Collection. Bibliometric analyses 
   were performed using CiteSpace software, the bibliometrix R package, and 
   VOSviewer software. Network maps were generated to assess the collaborations 
   between different countries, institutions, authors, and keywords. And clusters 
   map was generated to evaluate reference. RESULTS: A total of 790 articles related 
   to acupuncture therapy for cancer pain were identified. We observe that the 
   number of publications is gradually increasing over time. China and the United 
   States were the main contributors. Mem Sloan Kettering Canc Ctr (38 papers) and 
   Beijing Univ Chinese Med (28 papers) contributed the most publications, becoming 
   the leading contributors in this field. Although J Clin Oncol (28 articles) 
   ranked ninth in terms of publication volume, it was the journal with the most 
   citations and the highest number of IF (50.717) and H-index (494) at the same 
   time. MAO J from Mem Sloan Kettering Canc Ctr was the most prolific author (23 
   articles). The main hot topics included matters related to acupuncture (239 
   times), pain (199 times), management (139 times), quality of life (107 times), 
   electroacupuncture (100 times), and breast cancer (82 times). CONCLUSION: Our 
   bibliometric analysis provides a comprehensive overview of the development of 
   acupuncture for cancer pain, enabling relevant authors and research teams to 
   identify the current research status in this field. At the same time, acupuncture 
   for breast cancer (BC) pain, aromatase inhibitor-induced arthralgia (AIA), and 
   chemotherapy-induced peripheral neuropathy (CIPN) may soon become prospective 
   focus.
C1 Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   Department of Acupuncture, Sichuan Second Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   Department of Acupuncture, Sichuan Second Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, China.
   Department of Traditional Chinese Medicine, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shanxi, China.
   Sichuan Academy of Chinese Medicine Sciences, Chengdu, Sichuan, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD MAR 24
PY 2023
VL 13
IS 
BP 1077961
EP 1077961
DI 10.3389/fonc.2023.1077961 
PG 0
UT PubMed:36950556
PM 36950556
DA 2023-03-24
ER

PT J
AU Yang, M
   Chen, Y
   Wan, Y
   Shen, C
   Huang, J
AF Yang, Ming
   Chen, Yue
   Wan, Yuxiang
   Shen, Chen
   Huang, Jinchang
TI Acupuncture and moxibustion in integrative oncology and new progress in China.
SO Integrative medicine research
LA English
DT Review
DE Acupuncture; Evidence-based medicine; Integrative oncology; Moxibustion; Traditional Chinese Medicine
AB Acupuncture and moxibustion are increasingly gaining recognition in the clinical 
   and research fields of integrative oncology. This review synthesizes findings 
   from clinical guidelines, systematic reviews, meta-analyses, and randomized 
   controlled trials (RCTs) of acupuncture and moxibustion for cancer care. Clinical 
   evidence highlights acupuncture's efficacy in managing symptoms such as hot 
   flashes, pain, insomnia, fatigue, and constipation. Acupuncture also demonstrates 
   potential effects in reducing chemotherapy and radiotherapy-induced side effects. 
   Recent advancements in China shows integrated therapies combining acupuncture 
   with chemotherapy to enhance therapeutic outcomes. Additionally, laboratory 
   studies reveal the potential of acupuncture and moxibustion to modulate the tumor 
   microenvironment, boost chemotherapy efficacy, and strengthen immunity. Despite 
   these promising results, there is a pressing need for well-designed trials and 
   real-world studies to evaluate the long-term effects of standardized acupuncture 
   and moxibustion treatments in cancer care.
C1 Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, PR China.
   Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, PR China.
   Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, PR China.
   Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, PR China.
   Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, PR China.
NR 0
TC 0
SN 2213-423
EI 2213-422
J9 Integr Med Res
PD JUN 6
PY 2025
VL 14
IS 2
BP 101149
EP 101149
DI 10.1016/j.imr.2025.101149 
PG 0
UT PubMed:40475037
PM 40475037
DA 2025-06-06
ER

PT J
AU Ryu, HK
   Baek, YH
   Park, YC
   Seo, BK
AF Ryu, Hee Kyoung
   Baek, Yong-Hyeon
   Park, Yeon-Cheol
   Seo, Byung-Kwan
TI Current studies of acupuncture in cancer-induced bone pain animal models.
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Review
AB Acupuncture is generally accepted as a safe and harmless treatment option for 
   alleviating pain. To explore the pain mechanism, numerous animal models have been 
   developed to simulate specific human pain conditions, including cancer-induced 
   bone pain (CIBP). In this study, we analyzed the current research methodology of 
   acupuncture for the treatment of CIBP. We electronically searched the PubMed 
   database for animal studies published from 2000 onward using these search terms: 
   (bone cancer OR cancer) AND (pain OR analgesia) AND (acupuncture OR 
   pharmacopuncture OR bee venom). We selected articles that described cancer pain 
   in animal models. We analyzed the methods used to induce cancer pain and the 
   outcome measures used to assess the effects of acupuncture on CIBP in animal 
   models. We reviewed articles that met our inclusion criteria. Injection of 
   mammary cancer cells into the cavity of the tibia was the most frequently used 
   method for inducing CIBP in the animal models. Among the eight selected studies, 
   five studies demonstrated the effects of electroacupuncture on CIBP. The effects 
   of acupuncture were assessed by measuring pain-related behavior. Future 
   researches will be needed to ascertain the effectiveness of acupuncture for 
   treating CIBP and to explore the specific mechanism of CIBP in animal models.
C1 Department of Acupuncture & Moxibustion, Kyung Hee University Hospital at Gangdong, 149 Sangil-dong, Gangdong-gu, Seoul 134-727, Republic of Korea.
   Department of Acupuncture & Moxibustion, Kyung Hee University Hospital at Gangdong, 149 Sangil-dong, Gangdong-gu, Seoul 134-727, Republic of Korea.
   Department of Acupuncture & Moxibustion, Kyung Hee University Hospital at Gangdong, 149 Sangil-dong, Gangdong-gu, Seoul 134-727, Republic of Korea.
   Department of Acupuncture & Moxibustion, Kyung Hee University Hospital at Gangdong, 149 Sangil-dong, Gangdong-gu, Seoul 134-727, Republic of Korea.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD NOV 11
PY 2014
VL 2014
IS 
BP 191347
EP 191347
DI 10.1155/2014/191347 
PG 0
UT PubMed:25383081
PM 25383081
DA 2014-11-11
ER

PT J
AU Smeester, BA
   Al-Gizawiy, M
   O'Brien, EE
   Ericson, ME
   Triemstra, JL
   Beitz, AJ
AF Smeester, Branden A
   Al-Gizawiy, Mona
   O'Brien, Elaine E
   Ericson, Marna E
   Triemstra, Jennifer L
   Beitz, Alvin J
TI The effect of electroacupuncture on osteosarcoma tumor growth and metastasis: 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB Osteosarcoma is the most common malignant bone tumor found in children and 
   adolescents and is associated with many complications including cancer pain and 
   metastasis. While cancer patients often seek complementary and alternative 
   medicine (CAM) approaches to treat cancer pain and fatigue or the side effects of 
   chemotherapy and treatment, there is little known about the effect of acupuncture 
   treatment on tumor growth and metastasis. Here we evaluate the effects of six 
   different electroacupuncture (EA) regimens on osteosarcoma tumor growth and 
   metastasis in both male and female mice. The most significant positive effects 
   were observed when EA was applied to the ST-36 acupoint twice weekly (EA-2X/3) 
   beginning at postimplantation day 3 (PID 3). Twice weekly treatment produced 
   robust reductions in tumor growth. Conversely, when EA was applied twice weekly 
   (EA-2X/7), starting at PID 7, there was a significant increase in tumor growth. 
   We further demonstrate that EA-2X/3 treatment elicits significant reductions in 
   tumor lymphatics, vasculature, and innervation. Lastly, EA-2X/3 treatment 
   produced a marked reduction in pulmonary metastasis, thus providing evidence for 
   EA's potential antimetastatic capabilities. Collectively, EA-2X/3 treatment was 
   found to reduce both bone tumor growth and lung metastasis, which may be mediated 
   in part through reductions in tumor-associated vasculature, lymphatics, and 
   innervation.
C1 Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD NOV 15
PY 2013
VL 2013
IS 
BP 387169
EP 387169
DI 10.1155/2013/387169 
PG 0
UT PubMed:24228059
PM 24228059
DA 2013-11-15
ER

PT J
AU Yang, Q
   Xu, H
   Chen, H
   Chen, X
   Ji, W
   Cai, M
   Fu, H
   Li, H
   Hou, C
   Gao, J
AF Yang, Qing
   Xu, Huiqiong
   Chen, Huan
   Chen, Xinyu
   Ji, Wenting
   Cai, Minjin
   Fu, Han
   Li, Hang
   Hou, Chaoming
   Gao, Jing
TI Summary of evidence on Traditional Chinese Medicine nursing interventions in 
SO Geriatric nursing (New York, N.Y.)
LA English
DT Journal Article
DE Advanced cancer; Evidence summary; Evidence-based care; Hospice care; Traditional Chinese medicine nursing interventions
AB BACKGROUND: Patients with advanced cancer experience physical and psychological 
   pain that affects their quality of life. This review aimed to systematically 
   search, evaluate, and summarize the best evidence on Traditional Chinese Medicine 
   (TCM) nursing interventions in hospice care for patients with advanced cancer and 
   to provide an evidence-based foundation for clinical care. The time limit for the 
   search was from 2010 to September 2024. METHODS: A top-down search of relevant 
   literature was conducted according to the "6S" evidence model, including clinical 
   decisions, guidelines, best practices, evidence summaries, systematic reviews, 
   expert consensus, and randomized controlled trials (RCTs). The literature was 
   evaluated, and evidence was extracted independently by two researchers. The 
   evidence was appraised using the Appraisal of Guidelines Research and Evaluation 
   (AGREE) tool and integrated with an evidence-based team consisting of six 
   members. RESULTS: Thirty-three publications were included, including four 
   guidelines, two expert consensus, two clinical decisions, two evidence summaries, 
   twenty-one systematic reviews, and two RCTs. Thirty-six indicators of best 
   evidence were summarized from eight areas: TCM therapy, acupuncture therapy, 
   moxibustion therapy, acupressure therapy, music therapy, traditional Chinese 
   exercise therapy, auricular therapy, and aromatherapy. CONCLUSION: This review 
   summarizes the best evidence for TCM nursing interventions in hospice care for 
   patients with advanced cancer, which can be used by clinical healthcare 
   professionals to develop appropriate TCM nursing interventions in combination 
   with the actual situation and with full consideration of the needs and wishes of 
   the patients and their families to improve the patients' quality of life in 
   advanced stages.
C1 College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China.
   Division of Abdominal Tumor Multimodality Treatment, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, PR China.
   College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China.
   College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China.
   College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China.
   College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China.
   College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China.
   College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China.
   Division of Abdominal Tumor Multimodality Treatment, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, PR China.
   College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China. 
EM 19942021@cdutcm.edu.cn
NR 0
TC 0
SN 1528-398
EI 
J9 Geriatr Nurs
PD NOV 21
PY 2024
VL 61
IS 
BP 240
EP 249
DI 10.1016/j.gerinurse.2024.11.007 
PG 9
WC Humans; Medicine, Chinese Traditional; methods; Neoplasms; nursing; Hospice Care; methods; Quality of Life
UT PubMed:39566235
PM 39566235
DA 2024-11-21
ER

PT J
AU Chien, TJ
   Liu, CY
   Hsu, CH
AF Chien, Tsai-Ju
   Liu, Chia-Yu
   Hsu, Chung-Hua
TI Integrating acupuncture into cancer care.
SO Journal of traditional and complementary medicine
LA English
DT Review
DE Acupuncture; Cancer; Oncology
AB Oncology acupuncture has become a new and promising field of research because 
   more and more cancer patients have sought non-pharmacological alternatives for 
   symptom management. While different mechanisms have been proposed to explain its 
   efficacy, including theories of the neural system, endocrine cytokine or 
   immunological regulation, its eventual role has become that of alleviating the 
   side effects induced by chemotherapy or radiotherapy. In this paper, we have 
   reviewed the related articles focusing on acupuncture mechanisms and applications 
   in cancer care to provide a quick sketch of acupuncture in cancer care. A 
   detailed search was performed to identify the randomized controlled trials (RCTs) 
   and systematic reviews on acupuncture in oncology, using PUBMED and Cochrane. The 
   search terms included: Acupuncture, acupressure, and cancer. Additional terms 
   were used to target specific symptoms (i.e., breast cancer, hot flash, 
   xerostomia, nausea, vomiting, cancer pain, insomnia, fatigue). Two authors 
   independently extracted data for analysis and review. Ultimately, 25 articles 
   underwent full-text review. Recent trials made efforts in studying (a) hot 
   flashes in breast cancer, (b) xerostomia induced by radiotherapy in head and neck 
   cancer, (c) nausea and vomiting post-chemotherapy, (d) cancer pain, and (e) 
   fatigue and insomnia in cancer patients. Controversial results for acupuncture 
   application in cancer care appeared in different categories, but a trend emerged 
   that acupuncture can palliate cancer-related symptoms. The research to date 
   certainly offers us a valid complementary therapy in treating cancer-related 
   symptoms. Meanwhile, practical strategies with safe measures for enhancing the 
   efficacy are needed in further interventions, as well as continuing research with 
   a validated methodology.
C1 Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan. 
   Department of Internal Medicine, Division of Hemato-Oncology, Branch ofZhong-xing, Taipei City Hospital, Taipei, Taiwan.
   Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan. 
   Department of Traditional Chinese Medicine,Branch of Linsen and ChineseMedicine, Taipei City Hospital, Taipei, Taiwan. 
   Taiwan InternationalTraditional Chinese Medicine Training Center, Taiwan.
   Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan. 
   Department of Traditional Chinese Medicine,Branch of Linsen and ChineseMedicine, Taipei City Hospital, Taipei, Taiwan. 
   Taiwan InternationalTraditional Chinese Medicine Training Center, Taiwan.
NR 0
TC 0
SN 2225-411
EI 2225-411
J9 J Tradit Complement Med
PD APR 10
PY 2014
VL 3
IS 4
BP 234
EP 9
DI 10.4103/2225-4110.119733 
PG -225
UT PubMed:24716183
PM 24716183
DA 2014-04-10
ER

PT J
AU Golianu, B
   Yeh, AM
   Brooks, M
AF Golianu, Brenda
   Yeh, Ann Ming
   Brooks, Meredith
TI Acupuncture for Pediatric Pain.
SO Children (Basel, Switzerland)
LA English
DT Review
DE acupressure; acupuncture; integrative medicine; laser acupuncture; pain; pediatric; review
AB Chronic pain is a growing problem in children, with prevalence as high as 30.8%. 
   Acupuncture has been found to be useful in many chronic pain conditions, and may 
   be of clinical value in a multidisciplinary treatment program. The basic 
   principles of acupuncture are reviewed, as well as studies exploring basic 
   mechanisms of acupuncture and clinical efficacy. Conditions commonly treated in 
   the pediatric pain clinic, including headache, abdominal pain, fibromyalgia, 
   juvenile arthritis, complex regional pain syndrome, cancer pain, as well as 
   perioperative pain studies are reviewed and discussed. Areas in need of further 
   research are identified, and procedural aspects of acupuncture practice and 
   safety studies are reviewed. Acupuncture can be an effective adjuvant in the care 
   of pediatric patients with painful conditions, both in a chronic and an acute 
   setting. Further studies, including randomized controlled trials, as well as 
   trials of comparative effectiveness are needed.
C1 Department of Anesthesiology and Pain Medicine, Pediatric Anesthesiology, Stanford University, 300 Pasteur Dr. Stanford, CA 94304, USA.bgolianu@stanford.edu.
   Pediatric Gastroenterology, Stanford University, 750 Welch Road, Suite 116, Palo Alto CA 94304, USA. annming@stanford.edu.
   Department of Anesthesiology and Pain Medicine, Pediatric Anesthesiology, Stanford University, 300 Pasteur Dr. Stanford, CA 94304, USA.mrbrooks@stanford.edu.
NR 0
TC 0
SN 2227-906
EI 2227-906
J9 Children (Basel)
PD JAN 1
PY 2014
VL 1
IS 2
BP 134
EP 48
DI 10.3390/children1020134 
PG -86
UT PubMed:27417472
PM 27417472
DA 2014-01-01
ER

PT J
AU Li, Y
   Li, F
   Xiao, C
   Cao, J
   Xia, D
   Wu, Y
AF Li, Yanhua
   Li, Fangfei
   Xiao, Caizhi
   Cao, Jie
   Xia, Dongqin
   Wu, Yongzhong
TI Electroacupuncture therapy and bone cancer pain relief: experimental study on 
SO Frontiers in pain research (Lausanne, Switzerland)
LA English
DT Journal Article
DE analgesia; astrocytes; bone cancer pain; electroacupuncture; neuroimmune inflammation
AB BACKGROUND: Bone cancer pain is a common complication of advanced malignant 
   tumors.Chemotherapeutic drugs, regardless of their origin or type, are often 
   associated with various adverse effects such as gastrointestinal toxicity, immune 
   suppression, and acquired drug resistance, which can compromise patients' quality 
   of life and treatment compliance. Electroacupuncture, known for its safety and 
   analgesic effects, has been increasingly studied in bone cancer pain but the 
   underlying mechanism is not fully understood. OBJECTIVE: To explore the mechanism 
   of electroacupuncture in rats with bone cancer pain. METHODS: Forty-eight SD rats 
   were divided into four groups: blank control, sham electroacupuncture, 
   electroacupuncture-1, and electroacupuncture-2, with 12 rats in each group. 
   Except the control group, rats were inoculated with cancer cells in the left 
   tibia to induce bone cancer pain. The electroacupuncture groups received 
   interventions starting on the 6th day after modeling. Mechanical pain sensitivity 
   (PWT) and thermal pain sensitivity (PWL) were assessed, and the expression of 
   phosphorylated glycogen synthase kinase-3 (p-GSK-3) and glial fibrillary acidic 
   protein (GFAP) in the spinal cord were analyzed. HE staining was used to observe 
   tibial pathological changes. RESULTS: From the 6th day, PWT and PWL were 
   significantly reduced in the control group compared to the sham group (P < 0.05). 
   Electroacupuncture-1 significantly increased PWT and PWL compared to the sham 
   group (P < 0.05), while no significant changes were observed in 
   electroacupuncture-2 compared to the control. On day 12, spinal p-GSK-3 levels 
   were significantly lower and GFAP levels significantly higher in the model and 
   control groups compared to the electroacupuncture-1 group (P < 0.05). The 
   electroacupuncture-2 group showed no significant changes. Inflammatory cytokines 
   IL-1, IL-6, and TNF-α were significantly elevated in the model group compared to 
   the control (P < 0.05), but significantly reduced in the electroacupuncture-1 
   group (P < 0.05). HE staining showed cancer cell infiltration and bone tissue 
   damage in the sham and electroacupuncture groups. CONCLUSION: Electroacupuncture 
   significantly reduced the pain threshold in rats with bone cancer pain. This 
   effect is likely due to the down-regulation of GSK-3 activity, inhibition of 
   astrocyte activation, and reduction in inflammatory responses.
C1 Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China.
   Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China.
   Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China.
   Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China.
   Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China.
   Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China.
NR 0
TC 0
SN 2673-561
EI 2673-561
J9 Front Pain Res (Lausanne)
PD OCT 20
PY 2025
VL 6
IS 
BP 1597472
EP 1597472
DI 10.3389/fpain.2025.1597472 
PG 0
UT PubMed:41112967
PM 41112967
DA 2025-10-20
ER

PT J
AU Shi, A
   Yerebake, M
   Du, Z
   Li, L
   Yan, C
   Wang, J
AF Shi, Anqi
   Yerebake, Mamuke
   Du, Zhenping
   Li, Linghua
   Yan, Chaoqun
   Wang, Jun
TI Acupuncture as adjunctive therapy for cervical cancer pain: a systematic review 
SO Journal of pain and symptom management
LA English
DT Review
DE Acupuncture; adjunctive therapy; cancer pain; cervical cancer; meta-analysis
AB OBJECTIVE: The current study aimed to assess the efficacy of acupuncture as an 
   adjunctive therapy for pain management in cervical cancer patients through a 
   systematic review and meta-analysis. METHODS: Databases including the Web of 
   Science, Cochrane Library, PubMed, Embase, Wanfang, and China National Knowledge 
   Infrastructure (CNKI) were searched up to January 2025. Randomized controlled 
   trials (RCTs) investigating acupuncture combined with conventional treatment 
   versus conventional treatment alone for cervical cancer pain were incorporated. 
   Statistical analyses were performed using Stata 16.0 and RevMan 5.4. Standardized 
   mean differences (SMD) and 95% confidence intervals (CI) were computed for 
   continuous outcomes. Additionally, subgroup and sensitivity analyses were 
   performed to investigate the stability of the results and potential sources of 
   heterogeneity. RESULTS: Eight RCTs involving 627 participants were included in 
   the analysis. A meta-analysis demonstrated that, compared to conventional 
   treatment alone, acupuncture significantly enhanced pain relief as an adjunctive 
   therapy (SMD = -1.00, 95% CI [-1.27, -0.73], p < 0.00001). Manual acupuncture was 
   more effective than electroacupuncture (SMD = -1.25 vs. -0.46). Acupuncture use 
   also significantly improved gastrointestinal function (SMD = -1.57, 95% CI 
   [-3.10, -0.04]) and Karnofsky Performance Scale scores (SMD = 1.28, 95% CI [0.54, 
   2.02]). The acupoints most commonly utilized were Zusanli (ST36), Hegu (LI4), and 
   Taichong (LR3). CONCLUSION: Adjunctive acupuncture offers notable advantages in 
   reducing pain and enhancing function in cervical cancer patients, particularly 
   when manual techniques are applied to stimulate specific acupoints. These 
   findings support the inclusion of acupuncture in integrated cancer pain 
   management strategies.
C1 Department of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100700, China.
   Department of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100700, China.
   Department of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100700, China.
   Department of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100700, China.
   Department of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100700, China. 
   Department of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100700, China. 
EM angjunee@yeah.net
NR 0
TC 0
SN 1873-651
EI 
J9 J Pain Symptom Manage
PD JAN 3
PY 2026
VL 0
IS 
BP 
EP 
DI 10.1016/j.jpainsymman.2025.12.013 
PG 0
UT PubMed:41482014
PM 41482014
DA 2026-01-03
ER

PT J
AU Lopez, AM
AF Lopez, Ana Maria
TI Integrative oncology in cancer care: Reaching a tipping point.
SO Cancer
LA English
DT Editorial
DE acupuncture; anxiety; gyn oncology; integrative oncology; pain
C1 Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
NR 0
TC 0
SN 1097-014
EI 
J9 Cancer
PD JAN 18
PY 2023
VL 129
IS 6
BP 834
EP 835
DI 10.1002/cncr.34539 
PG 1
WC Humans; Integrative Oncology; Medical Oncology; Neoplasms; therapy
UT PubMed:36647627
PM 36647627
DA 2023-01-18
ER

PT J
AU Li, Y
   Hong, E
   Ye, W
   You, J
AF Li, Yan
   Hong, Ensi
   Ye, Wenguo
   You, Jianyu
TI Moxibustion as an Adjuvant Therapy for Cancer Pain: A Systematic Review and 
SO Journal of pain research
LA English
DT Review
DE cancer pain; meta-analysis; moxibustion; systematic review
AB PURPOSE: Pain is one of the most common and feared symptoms among cancer 
   patients. Unrelieved pain denies patients comfort and greatly affects their 
   overall quality of life. Moxibustion is commonly used to manage chronic pain. 
   However, its efficacy on cancer pain remains inconclusive. This study aimed to 
   evaluate the efficacy of moxibustion for cancer pain. METHODS: We searched seven 
   databases to obtain articles about moxibustion combined with pharmacotherapy for 
   cancer pain published before November 2022. All data extraction was carried out 
   independently by two investigators. RevMan 5.4 software was used for data 
   analysis. RESULTS: A total of ten trials involving 999 cases were included. The 
   results of the meta-analysis revealed that moxibustion combined with 
   pharmacotherapy was significantly better than drug therapy alone in improving 
   pain relief rate (RR =1.16, 95% CI = [1.04, 1.30], P = 0.01), reducing pain 
   scores (SMD = -1.43, 95% CI = [-2.09, -0.77], P < 0.0001), Shortening the onset 
   of analgesia (MD = -12.07, 95% CI = [-12.91, -11.22], P < 0.00001), prolonging 
   the duration of analgesia (MD = 3.69, 95% CI = [3.21, 4.18], P < 0.00001), and 
   improving quality of life (SMD = 2.48, 95% CI = [0.67, 4.29], P = 0.007). In 
   addition, moxibustion combined with pharmacotherapy can effectively reduce 
   adverse reactions of drugs (RR =0.35, 95% CI = [0.21, 0.57], P < 0.0001). 
   CONCLUSION: The evidence in this review supports moxibustion as an effective 
   adjuvant therapy for cancer pain management. However, high-quality RCTs are 
   needed to further confirm these findings. REGISTRATION NUMBER: PROSPERO 
   CRD42022370942.
C1 Jiangxi University of Chinese Medicine, Nanchang, People's Republic of China.
   Jiangxi University of Chinese Medicine, Nanchang, People's Republic of China.
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, 
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, People's Republic of China.
   Jiangxi University of Chinese Medicine, Nanchang, People's Republic of China.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD FEB 25
PY 2023
VL 16
IS 
BP 515
EP 525
DI 10.2147/JPR.S396696 
PG 10
UT PubMed:36824500
PM 36824500
DA 2023-02-25
ER

PT J
AU Ruela, LO
   Moura, CC
   Shieu, B
   Cho, YM
   Yeh, CH
   Pimentel, FF
   Stefanello, J
AF Ruela, Ludmila Oliveira
   Moura, Caroline de Castro
   Shieu, Bianca
   Cho, Yu-Min
   Yeh, Chao Hsing
   Pimentel, Franklin Fernandes
   Stefanello, Juliana
TI Auricular Therapy to Control Pain in Women With Breast Cancer: Protocol for 
SO JMIR research protocols
LA English
DT Journal Article
DE auricular acupuncture; auricular therapy; breast neoplasms; cancer pain; meta-analysis; pain; systematic review
AB BACKGROUND: The increased incidence of breast cancer implies the appearance of 
   frequent symptoms associated with disease and treatments, such as pain. For the 
   management of this issue, auricular therapy has been used in a complementary 
   manner, especially for its safety and analgesic action. OBJECTIVE: This 
   systematic review aims to summarize available evidence on the effects of 
   auricular therapy on pain in women undergoing breast cancer treatment. METHODS: 
   This is a systematic review that includes randomized controlled trials that 
   evaluated the effects of auricular therapy on pain in women with breast cancer, 
   as compared with other interventions (sham or placebo auricular therapy, other 
   nonpharmacological interventions, and routine pain treatments) during the 
   treatment of the disease. Pain, whether induced or not by cancer treatments, is 
   the main outcome to be evaluated. The search for the studies was performed in the 
   following databases: MEDLINE through PubMed, CINAHL, CENTRAL, Embase, Web of 
   Science, Scopus, VHL, TCIM Americas Network, CNKI, and Wanfang Data. The 
   reviewers have independently evaluated the full texts, and in the near future, 
   they will extract the data and assess the risk of bias in the included studies. 
   The certainty of the evidence will be assessed using the Grading of 
   Recommendations, Assessment, Development, and Evaluation (GRADE), and a 
   meta-analysis will be carried out to evaluate the intervention, considering the 
   homogeneity of the results, using the Cochran Q test and quantified by the 
   Higgins inconsistency index. The guidelines of the PRISMA-P (Preferred Reporting 
   Items for Systematic Review and Meta-Analysis Protocols) have been respected in 
   the elaboration of this protocol. RESULTS: The records screening stage has been 
   completed, and the synthesis and meta-analysis were conducted in February 2024. 
   We hope to have finished the preparation of the paper for publication by 
   September 2024. Review reporting will follow standard guidelines for reporting 
   systematic reviews. The results will be published in peer-reviewed scientific 
   journals. CONCLUSIONS: This review will compile the strength of evidence for the 
   use of auricular therapy in the management of pain in women with breast cancer 
   during the treatment of the disease, identifying gaps in the available evidence 
   as well as assisting health professionals in indicating the intervention for 
   clinical practice. TRIAL REGISTRATION: PROSPERO CRD42022382433; 
   https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=382433. 
   INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/55792.
C1 Ribeirão Preto College of Nursing, University of São Paulo, Ribeirão Preto, Brazil.
   Department of Medicine and Nursing, Federal University of Viçosa, Viçosa, Brazil.
   School of Nursing, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
   Cizik School of Nursing, The University of Texas Health Science Center at Houston, Houston, TX, United States.
   Cizik School of Nursing, The University of Texas Health Science Center at Houston, Houston, TX, United States.
   Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, Breast Disease Division, University of São Paulo, Ribeirão Preto, Brazil.
   Ribeirão Preto College of Nursing, University of São Paulo, Ribeirão Preto, Brazil.
NR 0
TC 0
SN 1929-074
EI 
J9 JMIR Res Protoc
PD OCT 15
PY 2024
VL 13
IS 
BP e55792
EP e55792
DI 10.2196/55792 
PG 1
WC Female; Humans; Auriculotherapy; Breast Neoplasms; complications; Meta-Analysis as Topic; Pain Management; methods; Randomized Controlled Trials as Topic; Systematic Reviews as Topic
UT PubMed:39405520
PM 39405520
DA 2024-10-15
ER

PT J
AU Zhang, Y
   Zhang, Y
   Liu, S
   Li, B
   Song, Z
   Han, Q
   Wang, C
   Wang, Y
   Yu, Y
   Xia, H
   Wang, C
   Li, J
AF Zhang, Yanji
   Zhang, Yingrong
   Liu, Suzhen
   Li, Bocun
   Song, Zhe
   Han, Qi
   Wang, Chang
   Wang, Yiwei
   Yu, Yanxin
   Xia, Hongjie
   Wang, Chun
   Li, Jia
TI Acupuncture for cancer pain: a scoping review of systematic reviews and 
SO Frontiers in oncology
LA English
DT Journal Article
DE acupuncture; alternative medicine (AM); cancer pain; scoping review; systematic reviews and meta-analyses
AB BACKGROUND: Due to the effectiveness and safety, acupuncture, one of the 
   traditional therapies of Chinese medicine, has been widely used in clinical 
   practice globally. A few systematic review or meta-analyses have proved its 
   effectiveness and safety towards patients with cancer pain, while there are no 
   syntheses among those evidence. The aim of this scoping review is to summarize 
   the evidence from systematic reviews of acupuncture for the treatment of cancer 
   pain and evaluate the breadth and methodological quality of these evidence as 
   well. METHODS: The scoping review process was guided by the methodology framework 
   of Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension 
   for scoping reviews (PRISMA ScR) and "Arkseyand O'Malley six-stage framework". 
   Electronic searches were carried out in several online databases from inception 
   to Jan 2022. Systematic reviews and meta-analyses that involve any type of 
   acupuncture for patients with cancer pain will be included. A pair of reviewers 
   independently screened full texts. Moreover, review characteristics were 
   extracted, and methodological quality was assessed using the AMSTAR 2 tool. 
   RESULTS: Twenty-five systematic reviews and meta-analyses were included. Manual 
   acupuncture is the most frequently included types of test group intervention 
   (48%), followed by acupuncture + medicine (28%), and auricular acupuncture (12%). 
   All the reviews have declared that acupuncture is an effective method for cancer 
   pain treatment. Eleven reviews (44%) aiming at evaluating the safety also have 
   confirmed that acupuncture is safe for treating cancer pain. However, most 
   included studies were conducted in China. With certain geographical limitations, 
   the findings were not representative within the region. The results of our review 
   may owe to the synthesis of all kinds of cancer pain, and only 2 reviews 
   described the type of cancer pain in detail. CONCLUSIONS: This scoping review 
   synthesizes and evaluates existing evidence of acupuncture for cancer pain. From 
   this scoping review of systematic reviews and meta-analyses, there are clear 
   recommendations for future studies: expanding the region of research in the world 
   and trying to conduct the study of different types of cancer pain in details as 
   much as possible. Evidences of acupuncture for cancer pain can inform clinical 
   decision-making. SYSTEMATIC REVIEW REGISTRATION: 
   https://inplasy.com/inplasy-2022-1-0073/, identifier INPLASY202210073.
C1 College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
   School of Biomedical Engineering and Imaging, Hubei University of Science and Technology, Xianning, Hubei, China.
   Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, Hubei, China.
   School of Biomedical Engineering and Imaging, Hubei University of Science and Technology, Xianning, Hubei, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD MAY 31
PY 2023
VL 13
IS 
BP 1169458
EP 1169458
DI 10.3389/fonc.2023.1169458 
PG 0
WC Systematic Reviews as Topic
UT PubMed:37256179
PM 37256179
DA 2023-05-31
ER

PT J
AU Pan, Y
   Yang, K
   Shi, X
   Liang, H
   Shen, X
   Wang, R
   Ma, L
   Cui, Q
   Yu, R
   Dong, Y
AF Pan, Yuanqing
   Yang, Kehu
   Shi, Xiue
   Liang, Haiqian
   Shen, Xiping
   Wang, Renjie
   Ma, Li
   Cui, Qi
   Yu, Runze
   Dong, Yi
TI Clinical Benefits of Acupuncture for the Reduction of Hormone Therapy-Related 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; breast cancer; hormone therapy–related side effects; quality of life; systematic review
AB IMPORTANCE: Acupuncture can help reduce unpleasant side effects associated with 
   endocrine therapy for breast cancer. Nevertheless, comprehensive evaluation of 
   current evidence from randomized controlled trials(RCTs) is lacking. OBJECTIVE: 
   To estimate the efficacy of acupuncture for the reduction of hormone 
   therapy-related side effects in breast cancer patients. EVIDENCE REVIEW: RCTs of 
   acupuncture in breast cancer patients that examined reductions in hormone 
   therapy-related side effects were retrieved from PubMed, EMBASE, Web of Science, 
   Ovid MEDLINE, and Cochrane Library databases through April 2016. The quality of 
   the included studies was evaluated according to the 5.2 Cochrane Handbook 
   standards, and CONSORT and STRICTA (Revised Standards for Reporting Interventions 
   in Clinical Trials of Acupuncture) statements. INTERVENTION: Interventions 
   included conventional acupuncture treatment compared with no treatment, placebo, 
   or conventional pharmaceutical medication. Major outcome measures were the 
   alleviation of frequency and symptoms and the presence of hormone therapy-related 
   side effects. Findings/Results. A total of 17 RCTs, including a total of 810 
   breast cancer patients were examined. The methodological quality of the trials 
   was relatively rigorous in terms of randomization, blinding, and sources of bias. 
   Compared with control therapies, the pooled results suggested that acupuncture 
   had moderate effects in improving stiffness. No significant differences were 
   observed in hot flashes, fatigue, pain, gastrointestinal symptoms, Kupperman 
   index, general well-being, physical well-being, tumor necrosis factor (TNF), and 
   interleukin (IL). CONCLUSIONS: Acupuncture therapy appears to be potentially 
   useful in relieving functional stiffness. However, further large-sample trials 
   with evidence-based design are still needed to confirm these findings.
C1 1 Tianjin Medical College, Tianjin, China.
   2 Lanzhou University, Lanzhou, Gansu, China.
   2 Lanzhou University, Lanzhou, Gansu, China.
   3 Gansu Rehabilitation Center Hospital, Lanzhou, China.
   4 Tianjin Pingjin Hospital, Tianjin, China.
   2 Lanzhou University, Lanzhou, Gansu, China.
   4 Tianjin Pingjin Hospital, Tianjin, China.
   5 General Hospital of Tianjin Medical University, Tianjin, China.
   6 The First Affiliated Hospital of Lanzhou University, Lanzhou, Gansu, China.
   1 Tianjin Medical College, Tianjin, China.
   1 Tianjin Medical College, Tianjin, China.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD AUG 18
PY 2018
VL 17
IS 3
BP 602
EP 618
DI 10.1177/1534735418786801 
PG 16
WC Acupuncture; methods; Animals; Breast Neoplasms; drug therapy; Clinical Trials as Topic; Female; Hormone Replacement Therapy; adverse effects; Humans
UT PubMed:30117343
PM 30117343
DA 2018-08-18
ER

PT J
AU Huang, J
   Zhao, L
   Xie, Y
   Wang, C
   Yang, X
   Huang, H
   Zhang, D
AF Huang, Jianhao
   Zhao, LiuYang
   Xie, YuFeng
   Wang, Chi
   Yang, XinJing
   Huang, HaiFu
   Zhang, Dian
TI Investigating the Analgesic Mechanisms of Acupuncture for Cancer Pain: Insights 
SO Journal of pain research
LA English
DT Journal Article
DE acupuncture; analgesic mechanism; cancer pain; deep learning; multimodal bioelectrical signals
AB PURPOSE: Cancer pain management remains a significant clinical challenge. While 
   acupuncture has shown potential in alleviating cancer pain, its underlying 
   mechanisms are not yet fully understood. This study investigates the 
   neurophysiological mechanisms underlying acupuncture's analgesic effects using 
   multimodal bioelectrical signal analysis. PATIENTS AND METHODS: Fifteen cancer 
   pain patients underwent acupuncture while wearing portable, multi-sensor devices 
   to capture bioelectrical signals. Pain levels were assessed using the Numerical 
   Rating Scale (NRS) before and during needle retention. Neurophysiological changes 
   were evaluated using Principal Component Analysis, Joint Time-Frequency Analysis, 
   power spectrum analysis, spectral analysis, and dynamic functional network 
   analysis. RESULTS: There was a significant reduction in NRS scores from 
   pre-treatment to the retention period, indicating pain relief. Principal 
   component analysis showed significant differences in bioelectrical signals 
   between these periods. Power spectrum analysis revealed decreased signal power 
   during retention. Functional network analysis demonstrated a reduction in 
   connectivity strength between electroencephalography and electromyography 
   signals. Spectral analysis identified distinct real-time and staged 
   characteristics of bioelectrical signals, with correlation analysis confirming a 
   positive relationship between NRS score changes and bioelectrical signal 
   alterations. CONCLUSION: Acupuncture alleviates cancer pain by reducing 
   functional connectivity between injured tissues and the brain, with immediate 
   effects. Prolonging needle retention may enhance therapeutic outcomes. These 
   findings provide new insights into the neurophysiological basis of acupuncture's 
   analgesic effects, supporting its role in cancer pain management.
C1 Department of Acupuncture and Moxibustion, Shenzhen Hospital (Fu Tian) of Guangzhou University of Chinese Medicine, Shenzhen, People's Republic of China.
   School of Computer and Software, Shenzhen University, Shenzhen, People's Republic of China.
   Department of Acupuncture and Moxibustion, Shenzhen Hospital (Fu Tian) of Guangzhou University of Chinese Medicine, Shenzhen, People's Republic of China.
   Faculty of Chinese Medicine and State Key Laboratory of Quality Research in 
   , Ganzhou Traditional Chinese Medicine Hospital, Ganzhou, People's Republic of China.
   Department of Acupuncture and Moxibustion, Shenzhen Hospital (Fu Tian) of Guangzhou University of Chinese Medicine, Shenzhen, People's Republic of China.
   Department of Acupuncture and Moxibustion, Shenzhen Hospital (Fu Tian) of Guangzhou University of Chinese Medicine, Shenzhen, People's Republic of China.
   School of Computer and Software, Shenzhen University, Shenzhen, People's Republic of China.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD MAR 25
PY 2025
VL 18
IS 
BP 1435
EP 1450
DI 10.2147/JPR.S503975 
PG 15
UT PubMed:40130202
PM 40130202
DA 2025-03-25
ER

PT J
AU Al-Atiyyat, N
   Obaid, A
AF Al-Atiyyat, Nijmeh
   Obaid, Abdullah
TI Management of peripheral neuropathy induced by chemotherapy in adults with 
SO International journal of palliative nursing
LA English
DT Review
DE Antineoplastic drugs; Chemotherapy-induced peripheral neuropathy; Management; Sensory neurotoxicity
AB AIM: To identify which of the examined agents or modalities were effective in the 
   management of chemotherapy-induced peripheral neuropathy (CIPN). METHODS: PubMed, 
   CINAHL, Medline, Science Direct and Ovid databases were used to search keywords. 
   The literature search identified 59 potentially relevant studies; after removing 
   duplicates and reviewing titles a total of 26 articles were examined. In the end, 
   a total of 18 studies met the inclusion criteria. FINDINGS: The preliminary data 
   for using lafutidine, acupuncture and sweet bee venom pharmacopuncture indicate 
   that they may be useful in CIPN management. The use of duloxetine was effective 
   and supported as a management of CIPN; likewise the use of scrambler therapy 
   significantly decreased CIPN pain. However, the use of electroacupuncture and 
   topical amitriptyline and ketamine was not supported. CONCLUSION: The use of 
   duloxetine was effective in CIPN management. Further studies with larger sample 
   size are needed.
C1 Hashemite University, Faculty of Nursing.
   Pain Management Nurse, King Hussein Cancer Center, Hashemite University.
NR 0
TC 0
SN 
EI 1357-632
J9 Int J Palliat Nurs
PD JAN 31
PY 2017
VL 23
IS 1
BP 13
EP 17
DI 10.12968/ijpn.2017.23.1.13 
PG 4
WC Adult; Antineoplastic Agents; adverse effects; Humans; Neoplasms; drug therapy; Peripheral Nervous System Diseases; chemically induced
UT PubMed:28132604
PM 28132604
DA 2017-01-31
ER

PT J
AU Kwag, E
   Joo, H
   Kim, SD
   Park, SJ
   Cho, JH
   Lee, NH
   Joo, JC
   Hyun, MH
   Chimonas, S
   Bao, T
   Mao, JJ
   Lee, JY
   Yoo, H
AF Kwag, Eunbin
   Joo, Haneum
   Kim, Soo-Dam
   Park, So Jung
   Cho, Jung Hyo
   Lee, Nam Hun
   Joo, Jong Cheon
   Hyun, Myung Han
   Chimonas, Susan
   Bao, Ting
   Mao, Jun J
   Lee, Jee Young
   Yoo, Hwaseung
TI Utilization Pattern of Acupuncture and Its Associated Predictors for Cancer Pain 
SO Diseases (Basel, Switzerland)
LA English
DT Journal Article
DE Korean medicine; acupuncture; cancer pain; integrative oncology
AB BACKGROUND: Cancer-related pain is a common and distressing symptom among 
   patients with cancer. Although acupuncture is widely used and supported by 
   growing evidence, its real-world use and related patient attitudes remain 
   underexplored in South Korea. This study aimed to investigate patterns of 
   acupuncture use and identify factors influencing its use among Korean cancer 
   patients experiencing pain. METHODS: A cross-sectional survey was conducted from 
   October 2023 to May 2024 at six Korean medicine hospitals. A total of 201 cancer 
   patients with pain completed a questionnaire assessing acupuncture use, pain 
   severity and interference, and beliefs using a modified version of the ABCAM 
   (Attitudes and Beliefs about Complementary and Alternative Medicine) instrument. 
   Treatment concerns, logistical barriers, and social norms were analyzed. RESULTS: 
   Of the 201 participants, 80.6% reported using acupuncture for cancer-related 
   pain. Pain severity was the only significant predictor of acupuncture use (OR = 
   1.53, 95% CI: 1.10-2.12, p = 0.01). Acupuncture users reported fewer concerns 
   about safety and side effects, fewer logistical barriers, and stronger 
   encouragement from family, healthcare providers, and peers. CONCLUSIONS: This is 
   the first study to explore real-world use of acupuncture for cancer pain in South 
   Korea. Greater pain severity, perceived safety, ease of access, and social 
   support were associated with higher acupuncture use. These findings suggest that 
   improved patient education and integration of acupuncture into cancer care may 
   enhance pain management for Korean patients.
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   East-West Cancer Center, Daejeon Korean Medicine Hospital, Daejeon University, Daejeon 34520, Republic of Korea.
   KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
   Department of Korean Internal Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
   Korean Medicine Hospital, Pusan National University, Yangsan 50612, Republic of 
   East-West Cancer Center, Daejeon Korean Medicine Hospital, Daejeon University, Daejeon 34520, Republic of Korea.
   East-West Cancer Center, Seoul Korean Medicine Hospital, Daejeon University, Seoul 05836, Republic of Korea.
   College of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea.
   Integrative Cancer Center, CHA Ilsan Medical Center, CHA University, Goyang 10444, Republic of Korea.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Dana-Farber Cancer Institute Zakim, Center for Integrative Therapies and Healthy Living, Boston, MA 02215, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
   Integrative Cancer Center, CHA Ilsan Medical Center, CHA University, Goyang 10444, Republic of Korea.
   East-West Cancer Center, Daejeon Korean Medicine Hospital, Daejeon University, Daejeon 34520, Republic of Korea.
NR 0
TC 0
SN 2079-972
EI 2079-972
J9 Diseases
PD SEP 26
PY 2025
VL 13
IS 9
BP 
EP 
DI 10.3390/diseases13090292 
PG 0
UT PubMed:41002728
PM 41002728
DA 2025-09-26
ER

PT J
AU Okifuji, A
AF Okifuji, Akiko
TI Editorial: Insights in cancer pain: 2022.
SO Frontiers in pain research (Lausanne, Switzerland)
LA English
DT Editorial
DE acupuncture; bone cancer; breakthrough pain; cancer pain; chemotherapy-induced neuropathic pain
C1 Department of Anesthesiology, School of Medicine, The University of Utah, Salt Lake City, UT, United States.
NR 0
TC 0
SN 2673-561
EI 2673-561
J9 Front Pain Res (Lausanne)
PD JUL 31
PY 2023
VL 4
IS 
BP 1236538
EP 1236538
DI 10.3389/fpain.2023.1236538 
PG 0
UT PubMed:37521942
PM 37521942
DA 2023-07-31
ER

PT J
AU Krukowska, K
   Krzyśkowska, S
   Kuchta, E
   Rudzińska, A
   Szklener, K
   Mańdziuk, S
AF Krukowska, Kamila
   Krzyśkowska, Sylwia
   Kuchta, Eliza
   Rudzińska, Anna
   Szklener, Katarzyna
   Mańdziuk, Sławomir
TI The effectiveness of acupuncture in cancer pain treatment.
SO Frontiers in oncology
LA English
DT Review
DE acupuncture; cancer pain; complementary medicine; pain management; quality of life
AB INTRODUCTION: In recent years, pain has been recognized as a primary factor 
   significantly diminishing the quality of life in cancer patients. Recent data 
   have prompted the establishment and increased application of non-pharmacological 
   interventions in pain management, such as acupuncture. OBJECTIVES: This review 
   assesses literature from 2018 to 2023 on the impact of acupuncture on pain 
   management and quality of life in cancer patients, with a particular focus on 
   reducing pain intensity. The effectiveness of acupuncture therapy was compared 
   with the traditional treatment of pain symptoms, with a focus on the patients' 
   quality of life. CONCLUSIONS: Although no conclusive scientific evidence confirms 
   the effectiveness of acupuncture in treating cancer pain symptoms, numerous 
   studies have demonstrated its ability to reduce pain, better control pain, 
   decrease analgesic intake, and significantly improve patients' quality of life. 
   Further research is needed to unequivocally confirm the clinical benefits of 
   acupuncture.
C1 Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, Lublin, Poland.
   Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, Lublin, Poland.
   Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, Lublin, Poland.
   Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, Lublin, Poland.
   Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, Lublin, Poland.
   Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, Lublin, Poland.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD DEC 6
PY 2024
VL 14
IS 
BP 1450105
EP 1450105
DI 10.3389/fonc.2024.1450105 
PG 0
UT PubMed:39640281
PM 39640281
DA 2024-12-06
ER

PT J
AU Lyman, GH
   Greenlee, H
   Bohlke, K
   Bao, T
   DeMichele, AM
   Deng, GE
   Fouladbakhsh, JM
   Gil, B
   Hershman, DL
   Mansfield, S
   Mussallem, DM
   Mustian, KM
   Price, E
   Rafte, S
   Cohen, L
AF Lyman, Gary H
   Greenlee, Heather
   Bohlke, Kari
   Bao, Ting
   DeMichele, Angela M
   Deng, Gary E
   Fouladbakhsh, Judith M
   Gil, Brigitte
   Hershman, Dawn L
   Mansfield, Sami
   Mussallem, Dawn M
   Mustian, Karen M
   Price, Erin
   Rafte, Susan
   Cohen, Lorenzo
TI Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement 
SO Journal of clinical oncology : official journal of the American Society of 
LA English
DT Journal Article
AB Purpose The Society for Integrative Oncology (SIO) produced an evidence-based 
   guideline on use of integrative therapies during and after breast cancer 
   treatment that was determined to be relevant to the American Society of Clinical 
   Oncology (ASCO) membership. ASCO considered the guideline for endorsement. 
   Methods The SIO guideline addressed the use of integrative therapies for the 
   management of symptoms and adverse effects, such as anxiety and stress, mood 
   disorders, fatigue, quality of life, chemotherapy-induced nausea and vomiting, 
   lymphedema, chemotherapy-induced peripheral neuropathy, pain, and sleep 
   disturbance. Interventions of interest included mind and body practices, natural 
   products, and lifestyle modifications. SIO systematic reviews focused on 
   randomized controlled trials that were published from 1990 through 2015. The SIO 
   guideline was reviewed by ASCO content experts for clinical accuracy and by ASCO 
   methodologists for developmental rigor. On favorable review, an ASCO Expert Panel 
   was convened to review the guideline contents and recommendations. Results The 
   ASCO Expert Panel determined that the recommendations in the SIO 
   guideline-published in 2017-are clear, thorough, and based on the most relevant 
   scientific evidence. ASCO endorsed the guideline with a few added discussion 
   points. Recommendations Key recommendations include the following: Music therapy, 
   meditation, stress management, and yoga are recommended for anxiety/stress 
   reduction. Meditation, relaxation, yoga, massage, and music therapy are 
   recommended for depression/mood disorders. Meditation and yoga are recommended to 
   improve quality of life. Acupressure and acupuncture are recommended for reducing 
   chemotherapy-induced nausea and vomiting. Acetyl-l-carnitine is not recommended 
   to prevent chemotherapy-induced peripheral neuropathy because of a possibility of 
   harm. No strong evidence supports the use of ingested dietary supplements to 
   manage breast cancer treatment-related adverse effects. Additional information is 
   available at: www.asco.org/supportive-care-guidelines .
C1 Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
   Gary H. Lyman and Heather Greenlee, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
   Kari Bohlke, American Society of ClinicalOncology, Alexandria, VA
   Ting Bao and Gary E. Deng, Memorial Sloan KetteringCancer Center
   Dawn L. Hershman, Columbia University Medical Center, New York;Karen M. Mustian, University of Rochester Medical Center, Rochester, NY
   AngelaM. DeMichele, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA
   Judith M. Fouladbakhsh, Oakland University, Rochester, MI;Brigitte Gil, Lahey Hospital and Medical Center, Burlington, MA
   Sami Mansfield,Cancer Wellness for Life, Shawnee, KS
   Sarah Cannon Cancer Institute, KansasCity, MO
   Dawn M. Mussallem, The Mayo Clinic, Jacksonville, FL
   Erin Price, SmithCenter for Healing and the Arts, Washington, DC
   Susan Rafte, Houston, TX
   andLorenzo Cohen, The University of Texas MD Anderson Cancer Center, Houston, TX.
NR 0
TC 0
SN 1527-775
EI 
J9 J Clin Oncol
PD JUN 12
PY 2018
VL 36
IS 25
BP 2647
EP 2655
DI 10.1200/JCO.2018.79.2721 
PG 8
WC Breast Neoplasms; therapy; Female; Humans; Integrative Oncology; methods
UT PubMed:29889605
PM 29889605
DA 2018-06-12
ER

PT J
AU Li, Z
   Xiong, Q
   Li, S
   Chen, W
   Xu, N
   Qiu, F
AF Li, Zeli
   Xiong, Qianwen
   Li, Shuwen
   Chen, Wenxiang
   Xu, Nenggui
   Qiu, Fanghua
TI Quantitative analysis and visualization of literature on acupuncture and related 
SO Frontiers in oncology
LA English
DT Journal Article
DE Citespace; acupuncture; colorectal cancer; literature measurement; visualization analysis
AB OBJECTIVE: We analyzed the literature describing the results of treatment of 
   colorectal cancer (CRC) using acupuncture in the past three decades from the Web 
   of Science (WoS) and Chinese databases (including CNKI, WANGFANG and VIP), and 
   summarized the current development of CRC treatment as well as future research 
   directions through the presentation of maps and visualization analysis. METHODS: 
   We searched the WoS and Chinese databases. Relevant articles were exported, and 
   the data were organized using Excel software and was visualized and analyzed 
   using CiteSpace software. RESULTS: A total of 355 articles from the WoS and 95 
   articles from Chinese databases were selected for inclusion in the analysis. The 
   articles in WoS were sourced from 174 journals, 1274 institutions, and 66 
   countries, and covered 299 keywords. The articles in the Chinese databases were 
   sourced from 43 journals, 111 institutions, and 3 countries, and included 126 
   keywords. The article with the most citations in the WoS was cited 128 times and 
   in the Chinese databases, the article with the most citations was cited 120 
   times. Acupuncture, CRC, rectal cancer, apoptosis, warm acupuncture, traditional 
   Chinese medicine (TCM) and gastrointestinal function were mentioned most 
   frequently in the WoS. CRC, electroacupuncture, gastrointestinal function, rectal 
   cancer, acupuncture and moxibustion, acupuncture, and colon cancer were mentioned 
   most frequently in the Chinese databases. CONCLUSION: Both the WoS and Chinese 
   databases showed a gradual increase in the number of articles related to 
   acupuncture treatment for CRC, indicating a growing interest in this area. 
   Acupuncture treatments are diverse, including warm acupuncture, auricular 
   acupuncture, acupuncture injection, and electroacupuncture. They are often used 
   in combination with drugs to treat symptoms such as depression, nausea and 
   vomiting, pain, diarrhea, and urinary and fecal incontinence, which are commonly 
   associated with CRC.
C1 Clinical Medical College of Acu-Moxi and Rehabilitation, South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine,Guangzhou, China.
   Guangzhou University of Chinese Medicine, Guangzhou, China.
   Guangzhou University of Chinese Medicine, Guangzhou, China.
   The Affiliated TCM Hospital of Guangzhou Medical University, Guangzhou, China.
   Clinical Medical College of Acu-Moxi and Rehabilitation, South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine,Guangzhou, China.
   Department of Infection Control, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD JAN 22
PY 2024
VL 13
IS 
BP 1290588
EP 1290588
DI 10.3389/fonc.2023.1290588 
PG 0
UT PubMed:38250554
PM 38250554
DA 2024-01-22
ER

PT J
AU Chan, A
   Nasr, R
   Arcos, D
   Kagramanov, D
   Asuzu, C
   Bao, T
   Cheung, YT
   Kwon, JH
   Lacey, J
   Lee, RT
   Lustberg, M
   Ohaeri, BM
   Rao, S
   Soto-Perez-de-Celis, E
   Witt, CM
   Lopez, AM
AF Chan, Alexandre
   Nasr, Reem
   Arcos, Daniela
   Kagramanov, Dalia
   Asuzu, Chioma
   Bao, Ting
   Cheung, Yin Ting
   Kwon, Jung Hye
   Lacey, Judith
   Lee, Richard T
   Lustberg, Maryam
   Ohaeri, Beatrice M
   Rao, Santosh
   Soto-Perez-de-Celis, Enrique
   Witt, Claudia M
   Lopez, Ana Maria
TI Evaluation of integrative oncology modalities for symptom management: a MASCC/SIO 
SO BMC complementary medicine and therapies
LA English
DT Journal Article
DE Cancer; Cancer supportive care; Global perspectives; Integrative oncology; Oncology
AB BACKGROUND: With growing evidence pointing towards the potential of integrative 
   oncology modalities (IOM) in addressing cancer and cancer-treatment related 
   symptoms, research on IOM utilization and implementation is warranted. This study 
   examines global stakeholder perspectives on integrative oncology (IO) utilization 
   for supportive cancer care. METHODS: Members of the Multinational Association of 
   Supportive Care in Cancer (MASCC) and the Society for Integrative Oncology (SIO) 
   completed a survey on the utilization of IOM for supportive cancer care. 
   Descriptive statistics were used to assess demographic data, IOM usage patterns, 
   IOM education, and financial considerations for utilizing IOM. RESULTS: Among 344 
   participants representing eight geographical regions, 70% reported having 
   utilized or recommended IOM and 79% perceived IOM to be underutilized in cancer 
   supportive care. Acupuncture (48%), exercise classes (39%), nutrition (38%), 
   breathing/yoga (38%) and personalized exercise (38%) were among the most utilized 
   IOM across regions. Relatedly, the symptoms for which IOM were most recommended 
   for persons with a diagnosis of cancer in active treatment [AT] or completed 
   treatment [CT] respectively were emotional (AT 23%; CT 26%), pain (AT 22%; CT 
   20%), gastrointestinal (AT 21%; CT 12%) and fatigue (AT 15%; CT 16%). The 
   perceived availability of integrative medicine training was highest in North 
   America (69%). Across regions, self-pay (20%-67%), private insurance (0%-26%) and 
   government insurance (7%-40%) were the most common forms of payment for IOM. The 
   IOM most recommended in high-income countries (acupuncture, exercise, massage, 
   individual exercise) varied from the IOM most recommended in low-middle income 
   countries (nutrition counseling, exercise classes, breathing, acupuncture). 
   CONCLUSION: This study provides valuable insights into global utilization 
   patterns of IOM in supportive cancer care, highlighting that while most 
   respondents have utilized IOM, there is a perceived underutilization overall. Our 
   results show significant regional differences in the availability of integrative 
   oncology education and hint to financial barriers impacting IOM use. Further 
   research is necessary to explore these aspects and inform strategies for 
   supporting IOM implementation efforts.
C1 Department of Clinical Pharmacy Practice, University of California Irvine, 802 W Peltason Drive, Irvine, CA, 92697-4625, USA. a.chan@uci.edu.
   Department of Clinical Pharmacy Practice, University of California Irvine, 802 W Peltason Drive, Irvine, CA, 92697-4625, USA.
   Department of Clinical Pharmacy Practice, University of California Irvine, 802 W Peltason Drive, Irvine, CA, 92697-4625, USA.
   Department of Clinical Pharmacy Practice, University of California Irvine, 802 W Peltason Drive, Irvine, CA, 92697-4625, USA.
   Department of Guidance and Counselling, University of Ibadan, Ibadan, Nigeria.
   Zakim Center for Integrative Therapies and Healthy Living, Dana-Farber Cancer Institute, Boston, USA.
   School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, Shatin, China.
   Division of Hemato-oncology, Chung-Ang University College of Medicine, Gyeonggi-do, South Korea.
   Department of Supportive Care and Integrative Oncology, Chris O'Brien Lifehouse Comprehensive Cancer Centre, NSW, Sydney, Australia.
   Cherng Family Center for Integrative Oncology, City of Hope Comprehensive Cancer Center, Duarte, USA.
   Breast Cancer Center, Smilow Cancer Hospital, Yale University, New Haven, USA.
   College of Medicine, University of Ibadan, Ibadan, Nigeria.
   University Hospitals Seidman Cancer Center, Cleveland, USA.
   Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Ciudad de Mexico, Mexico.
   UC Health Diane O'Connor Thompson Breast Center, Auschutz Medical Campus, 
   Institute for Complementary and Integrative Medicine, University Hospital Zurich, Zürich, Switzerland.
   Sidney Kimmel Comprehensive Cancer Center, Thomas Jefferson University, Philadelphia, USA.
NR 0
TC 0
SN 2662-767
EI 
J9 BMC Complement Med Ther
PD NOV 4
PY 2025
VL 25
IS 1
BP 406
EP 406
DI 10.1186/s12906-025-05157-6 
PG 0
WC Humans; Neoplasms; therapy; Integrative Oncology; statistics & numerical data; Male; Female; Middle Aged; Adult; Surveys and Questionnaires; Aged
UT PubMed:41184943
PM 41184943
DA 2025-11-04
ER

PT J
AU Shi, GX
   Tu, JF
   Wang, TQ
   Yang, JW
   Wang, LQ
   Lin, LL
   Wang, Y
   Li, YT
   Liu, CZ
AF Shi, Guang-Xia
   Tu, Jian-Feng
   Wang, Tian-Qi
   Yang, Jing-Wen
   Wang, Li-Qiong
   Lin, Lu-Lu
   Wang, Yu
   Li, Yong-Ting
   Liu, Cun-Zhi
TI Effect of Electro-Acupuncture (EA) and Manual Acupuncture (MA) on Markers of 
SO Journal of pain research
LA English
DT Journal Article
DE electro-acupuncture; inflammation; knee osteoarthritis; manual acupuncture
AB BACKGROUND: Inflammation plays a significant role in the pathogenesis of knee 
   osteoarthritis (KOA). Although both electro-acupuncture (EA) and manual 
   acupuncture (MA) are known to influence systemic inflammation, little is known 
   about the potential changes in inflammation as a working mechanism of EA and MA 
   in KOA. METHODS: Data from the Acupuncture for Knee Osteoarthritis Trial (ATKOA) 
   were used. Serum concentrations of inflammatory factors (tumor necrosis factor-α 
   (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8, IL-18, IL-4, IL-10, IL-13, IL-15, 
   IL-17, monocyte chemotactic protein-1 (MCP-1), CC-chemokine ligand 5 (CCL5), and 
   cartilage degradation biomarkers (matrix metalloproteinase-1 MMP-1, MMP-3, MMP-13 
   and cartilage oligomeric matrix protein COMP)) were measured at baseline and 
   after 8 weeks of treatment. Clinical outcomes were valid and reliable 
   self-reported pain and function measures for osteoarthritis using the Western 
   Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and visual 
   analogue scale (VAS) at baseline and post-treatment. RESULTS: Both 8-weeks EA and 
   MA significantly reduced pro-inflammatory cytokines (TNFα, IL-1β), and cartilage 
   degradation biomarkers (MMP-3, MMP-13) significantly increased the 
   anti-inflammatory cytokine IL-13 compared with pre-treatment (p<0.05). Further, 
   the reduction of TNF-α was more significant in EA when compared to MA (p=0.046). 
   While there was no significant difference between groups in cytokines IL-1β 
   (p=0.102), MMP-3 (p=0.113), MMP-13 (p=0.623) or IL-13 (p=0.935). Moreover, in 
   both EA and MA, the effect of acupuncture on the VAS and WOMAC function scale 
   after 8 weeks is clinically important, although no significant differences were 
   found between groups. CONCLUSION: Eight weeks of both EA and MA seem to provide 
   improvement in pain relief and function among individuals with mild to moderate 
   knee OA. This benefit is partly mediated by changes of major inflammatory factors 
   TNF-α, IL-1β and IL-13. TRIAL REGISTRATION: Controlled-Trials.com Identifier: 
   NCT03274713.
C1 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, People'sRepublic of China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
   Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, People'sRepublic of China.
   Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, People'sRepublic of China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD SEP 10
PY 2020
VL 13
IS 
BP 2171
EP 2179
DI 10.2147/JPR.S256950 
PG 8
UT PubMed:32904642
PM 32904642
DA 2020-09-10
ER

PT J
AU Yan, S
   Yan, F
   Liangyu, P
   Fei, X
AF Yan, Shen
   Yan, Feng
   Liangyu, Pei
   Fei, Xu
TI Assessment of non-pharmacological nursing strategies for pain management in tumor 
SO Frontiers in pain research (Lausanne, Switzerland)
LA English
DT Journal Article
DE acupressure; acupuncture; aromatherapy; cancer-related pain; massage; reflexology
AB SUMMARY BACKGROUND: Cancer is a multifactorial disease associated with intense 
   pain and fatigue. Pain is the main discomfort experienced during cancer 
   treatment, particularly as a major side effect of chemotherapy. OBJECTIVE: This 
   study has aimed to investigate the effectiveness of non-pharmacological nursing 
   strategies, including reflexology, aromatherapy, acupressure, massage therapy and 
   acupuncture, in the management of cancer-associated pain. Moreover, it provides 
   evidence-based recommendations for integrating these interventions into standard 
   pain management protocols. SEARCH METHODOLOGY: We gathered data from three major 
   online databases; PubMed, the Cochrane Library and Embase. For the analysis, we 
   exclusively targeted randomized controlled trials (RCTs) assessing the 
   effectiveness of non-pharmacological interventions in managing cancer-related 
   pain. No language restrictions were applied, and pain was considered the primary 
   outcome measure. RESULTS: Seventeen RCTs (n = 1,070) were included in this 
   meta-analysis from 166 eligible studies. The pooled effect size demonstrated that 
   all evaluated non-pharmacological nursing strategies, including aromatherapy, 
   massage, reflexology, acupressure and acupuncture significantly reduced 
   cancer-related pain compared to usual care (p < 0.001). Moreover, the reflexology 
   and massage showed negligible heterogeneity among other interventions. 
   CONCLUSION: This meta-analysis found the significant effectiveness of 
   non-pharmacological nursing strategies, particularly reflexology and massage in 
   reducing cancer-related pain. The findings support their integration into 
   clinical practice, providing evidence-based recommendations for enhancing 
   standard pain management protocols.
C1 Department of Cancer V, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Department of Cancer V, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Department of Cancer V, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Department of Cancer V, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
NR 0
TC 0
SN 2673-561
EI 2673-561
J9 Front Pain Res (Lausanne)
PD APR 30
PY 2025
VL 6
IS 
BP 1447075
EP 1447075
DI 10.3389/fpain.2025.1447075 
PG 0
UT PubMed:40303318
PM 40303318
DA 2025-04-30
ER

PT J
AU Wang, H
   Qu, S
   Zhou, T
   Hu, Q
   Zhao, X
   Yang, Q
   Chi, H
   Luo, S
   Li, X
   Ke, H
   He, X
   Zhao, H
AF Wang, Hanzhi
   Qu, Siying
   Zhou, Tianshu
   Hu, Qunqi
   Zhao, Xiaoxuan
   Yang, Qujia
   Chi, Hengyu
   Luo, Shiling
   Li, Xinyue
   Ke, Huanxiao
   He, Xiaofen
   Zhao, Hongli
TI Current Perspectives and Trend of Acupuncture in Breast Cancer-Related Symptoms: 
SO Journal of pain research
LA English
DT Review
DE CiteSpace; VOSviewer; acupuncture; bibliometric study; breast cancer-related symptoms; cancer pain
AB PURPOSE: This bibliometric research aims to delineate global publication trends 
   and emerging research interests in the use of acupuncture for breast cancer 
   (BC)-related symptoms treatment over the past three decades. Furthermore, it 
   identifies influential institutions, potential collaborative partners, and future 
   research trends, thereby providing guidance for relevant, novel research 
   directions. METHODS: Scientific publications related to acupuncture for 
   BC-related symptoms were gathered from the Web of Science Core Collection (WoSCC) 
   from 1993 to 2023. Four software applications were principally used to analyze 
   the resulting data: the "bibliometrix" package in the R environment (version 
   4.2.3), VOSviewer, CiteSpace6.1.R6, and the bibliometrics website. These 
   applications were employed to evaluate different parameters. RESULTS: A total of 
   621 papers on acupuncture in BC-related symptoms treatment were analyzed. The 
   United States, China, and South Korea contributed the most, with Memorial Sloan 
   Kettering Cancer Center, and Columbia University leading institutions. It is 
   interesting to mention that Mao, Jun J. and Molassiotis, A. feature among the top 
   10 authors and co-cited authors. JAMA is the leading journal, with an ongoing 
   focus on acupuncture's effectiveness. Keywords show that the initial research 
   focus was mainly on "vasomotor symptoms", but in recent years there has been a 
   gradual shift towards "pain", "chemotherapy-induced peripheral neuropathy 
   (CIPN)", "electroacupuncture", and "non-specific effects". CONCLUSION: 
   Acupuncture has demonstrated a unique value in the process of adjuvant treatment 
   of BC-related symptoms, and has been shown to be effective in reducing pain, 
   eliminating fatigue, and improving quality of life. The study of the mechanisms 
   of acupuncture and the application of electroacupuncture are possible future 
   research priorities in this field. This study offers a deep perspective on 
   acupuncture for BC research, highlighting key points and future trends.
C1 Department of Traditional Chinese Medicine (TCM) Gynecology, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University,Hangzhou City, Zhejiang Province, People's Republic of China.
   Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, People's 
   Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, People's Republic of China.
   Wenzhou Medical University, Wenzhou City, Zhejiang Province, People's Republic of China.
   Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, People's Republic of China.
   Department of Traditional Chinese Medicine (TCM) Gynecology, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University,Hangzhou City, Zhejiang Province, People's Republic of China.
   Department of Traditional Chinese Medicine (TCM) Gynecology, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University,Hangzhou City, Zhejiang Province, People's Republic of China.
   Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, People's 
   Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, People's Republic of China.
   Department of Traditional Chinese Medicine (TCM) Gynecology, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University,Hangzhou City, Zhejiang Province, People's Republic of China.
   Women's Hospital, School of Medicine, Zhejiang University, Hangzhou City, Zhejiang Province, People's Republic of China.
   Department of Traditional Chinese Medicine (TCM) Gynecology, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University,Hangzhou City, Zhejiang Province, People's Republic of China.
   Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, People's 
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture andNeurology of Zhejiang Province, Hangzhou City, Zhejiang Province, People'sRepublic of China.
   Department of Traditional Chinese Medicine (TCM) Gynecology, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University,Hangzhou City, Zhejiang Province, People's Republic of China.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD DEC 11
PY 2023
VL 16
IS 
BP 4165
EP 4180
DI 10.2147/JPR.S442151 
PG 15
UT PubMed:38078016
PM 38078016
DA 2023-12-11
ER

PT J
AU Faruqi, F
   Ruddy, KJ
   Blackmon, S
AF Faruqi, Fahad
   Ruddy, Kathryn J
   Blackmon, Shanda
TI Integrative Approaches to Minimize Peri-operative Symptoms.
SO Current oncology reports
LA English
DT Review
DE Acupuncture; CAM; Complementary medicine; Guided imagery; Integrative medicine; Loving-kindness meditation; PTPS; Peri-operative symptoms; Post-thoracotomy pain syndrome
AB PURPOSE OF REVIEW: Cancer patients who require surgery often experience 
   peri-operative symptoms, including nausea, anxiety, and pain, which can 
   significantly impair quality of life. Here, we review the evidence for using 
   integrative approaches to manage these peri-operative symptoms. RECENT FINDINGS: 
   Conventional peri-operative pharmacologic interventions, such as opiates for pain 
   control, can lead to adverse effects such as respiratory depression, prolonged 
   hospital course, and long-term dependence. Integrative medicine, also known as 
   complementary and alternative medicine (CAM), has been explored as way to reduce 
   peri-operative symptoms. Acupuncture, guided imagery, and loving-kindness 
   meditation have all shown potential efficacy in reducing both peri-operative pain 
   and anxiety in retrospective studies and small randomized controlled trials. 
   Integrative medicine techniques, such as acupuncture, are a promising approach to 
   control peri-operative symptoms without the associated adverse effects of more 
   conventional pharmacologic interventions.
C1 Mayo Clinic, Rochester, MN, USA. faruqi.fahad@mayo.edu.
   Mayo Clinic, Rochester, MN, USA.
   Mayo Clinic, Rochester, MN, USA.
NR 0
TC 0
SN 1534-626
EI 
J9 Curr Oncol Rep
PD APR 29
PY 2021
VL 23
IS 6
BP 73
EP 73
DI 10.1007/s11912-021-01051-9 
PG 0
WC Anxiety; therapy; Enhanced Recovery After Surgery; Humans; Integrative Medicine; methods; Nausea; therapy; Neoplasms; surgery; Pain Management; methods; Perioperative Care
UT PubMed:33907909
PM 33907909
DA 2021-04-29
ER

PT J
AU Wei, R
   Huang, Z
AF Wei, Ran
   Huang, Zuozhen
TI Acupuncture-induced pain relief and anti-inflammatory effects in chronic pelvic 
SO American journal of translational research
LA English
DT Review
DE Acupuncture and moxibustion; anti-inflammatory; chronic pelvic inflammatory disease; pain relief; pelvic mass regression; smooth fallopian tubes
AB OBJECTIVE: To systematically evaluate the effects of acupuncture and moxibustion 
   on pain relief, inflammatory biomarkers, and reproductive outcomes in patients 
   with chronic pelvic inflammatory disease (CPID). METHOD: A systematic search was 
   conducted in PubMed, Embase, Cochrane Library, CNKI, and Wanfang for studies 
   published between January 2010 and December 2023. Randomized controlled trials 
   (RCTs) comparing acupuncture with sham/conventional control interventions in CPID 
   patients were included. The primary outcomes included pain intensity (visual 
   analog scale, VAS), inflammatory biomarkers (C-reactive protein [CRP], 
   interleukin-6 [IL-6], tumor necrosis factor alpha [TNF-α]), and CPID specific 
   indicators (fallopian tube patency and pelvic mass regression). Data were 
   analyzed using a random-effects model (RevMan 5.3/Stata 16). RESULT: Thirteen 
   RCTs involving 658 patients were included. Acupuncture significantly reduced pain 
   intensity (standardized mean deviation [SMD]=-1.42, 95% confidence interval [CI]: 
   -1.66 to -1.18), CRP (SMD=-3.89), IL-6 (SMD=-5.00), TNF-α (SMD=0.60) (all 
   P<0.001). CPID-specific outcomes were improved, with higher rates of fallopian 
   tube patency (hazard ratio [RR] =1.35) and pelvic mass regression (RR=1.44; both 
   P<0.01). Moreover, acupuncture improved quality of life (SMD=0.55, P<0.0001), 
   increased pregnancy rate (RR=1.32), and reduced recurrence rates (RR=0.68; both 
   P<0.05). Electroacupuncture combined with herbal medicine (≥8 weeks) showed the 
   most pronounced therapeutic benefits. CONCLUSION: Electroacupuncture combined 
   with herbal medicine significantly alleviates pelvic pain, reduces systemic 
   inflammation, and enhances reproductive outcomes in patients with CPID.
C1 College of Ancient Chinese Studies, Beijing University of Chinese Medicine Beijing 100029, China.
   College of Ancient Chinese Studies, Beijing University of Chinese Medicine Beijing 100029, China.
NR 0
TC 0
SN 1943-814
EI 1943-814
J9 Am J Transl Res
PD DEC 19
PY 2025
VL 17
IS 11
BP 8985
EP 8998
DI 10.62347/GLPQ2895 
PG 13
UT PubMed:41415097
PM 41415097
DA 2025-12-19
ER

PT J
AU Xie, Y
   Li, Y
   Liu, D
   Zou, Y
   Wang, H
   Pan, L
AF Xie, Yuan
   Li, Yuanyuan
   Liu, Di
   Zou, Yi
   Wang, Haiying
   Pan, Liang
TI Clinical rules of Acupoint selection for cancer pain opioid-induced constipation 
SO Heliyon
LA English
DT Journal Article
DE Acupoint selection rule; Acupoint therapy; Cancer pain opioid-related constipation; Data mining
AB OBJECTIVE: To analyse and summarise the regularity of acupoint selection in the 
   treatment of opioid-induced constipation (OIC) in patients with cancer pain using 
   a data mining technique and provide a reference for clinical practice and more 
   valuable treatment options. METHODS: The acupoint prescription database for the 
   treatment of OIC-related cancer pain was established by searching the relevant 
   literature on randomised controlled trials involving acupoint therapy for 
   OIC-related cancer pain in seven major databases, including the China National 
   Knowledge Infrastructure, Wanfang and VIP Chinese scientific journal databases, 
   from database establishment to December 31, 2022. The main therapeutic measures 
   of acupoint prescription, frequency of acupoint use and its subordinate meridians 
   and subordinate sites were then analysed. Through systematic clustering and 
   association rule analysis, the core acupoint prescriptions and most commonly used 
   acupoint compatibility of acupoint therapy for OIC-related cancer pain were 
   obtained. RESULTS: A total of 649 articles were retrieved, with 72 articles 
   included after screening. The treatment measures were found to be mainly acupoint 
   applications involving 28 acupoints, with a total frequency of 234. The three 
   most frequently used acupoints were Shenque, Tianshu and Zusanli. The number of 
   points used in the Foot-Yangming stomach meridian was the highest. Commonly used 
   acupoints were mainly distributed in the abdomen. The compatibility of two 
   commonly used acupoints was obtained through systematic clustering. Through 
   association rule analysis, it was found that in the compatibility of acupoints, 
   the strongest correlation was between Tianshu and Zusanli, and their frequency of 
   application was the highest. CONCLUSION: Tianshu and Zusanli are the core 
   acupoints for acupoint therapy in the treatment of OIC-related cancer pain, and 
   the Shangjuxu-Zhigou-Zusanli, Qihai-Guanyuan and Zhongwan-Tianshu acupoints 
   exhibit the highest compatibility. This study provides a reference for the 
   clinical acupoint selection programme of acupuncture and moxibustion in the 
   treatment of OIC-related cancer pain.
C1 Beijing University of Chinese Medicine, Beijing, 100029, China.
   Department of Acupuncture, Dongfang Hospital Beijing University of Chinese Medicine, Beijing, 100078, China.
   Department of Acupuncture, Dongfang Hospital Beijing University of Chinese Medicine, Beijing, 100078, China.
   Department of Acupuncture, Dongfang Hospital Beijing University of Chinese Medicine, Beijing, 100078, China.
   Beijing University of Chinese Medicine, Beijing, 100029, China.
   Department of Acupuncture, Dongfang Hospital Beijing University of Chinese Medicine, Beijing, 100078, China.
NR 0
TC 0
SN 2405-844
EI 2405-844
J9 Heliyon
PD MAR 5
PY 2024
VL 10
IS 5
BP e26170
EP e26170
DI 10.1016/j.heliyon.2024.e26170 
PG 1
UT PubMed:38439874
PM 38439874
DA 2024-03-05
ER

PT J
AU Bao, Y
   Kong, X
   Yang, L
   Liu, R
   Shi, Z
   Li, W
   Hua, B
   Hou, W
AF Bao, Yanju
   Kong, Xiangying
   Yang, Liping
   Liu, Rui
   Shi, Zhan
   Li, Weidong
   Hua, Baojin
   Hou, Wei
TI Complementary and alternative medicine for cancer pain: an overview of systematic 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Review
AB Background and Objective. Now with more and more published systematic reviews of 
   Complementary and Alternative Medicine (CAM) on adult cancer pain, it is 
   necessary to use the methods of overview of systematic review to summarize 
   available evidence, appraise the evidence level, and give suggestions to future 
   research and practice. Methods. A comprehensive search (the Cochrane Library, 
   PubMed, Embase, and ISI Web of Knowledge) was conducted to identify all 
   systematic reviews or meta-analyses of CAM on adult cancer pain. And the evidence 
   levels were evaluated using GRADE approach. Results. 27 systematic reviews were 
   included. Based on available evidence, we could find that psychoeducational 
   interventions, music interventions, acupuncture plus drug therapy, Chinese herbal 
   medicine plus cancer therapy, compound kushen injection, reflexology, lycopene, 
   TENS, qigong, cupping, cannabis, Reiki, homeopathy (Traumeel), and creative arts 
   therapies might have beneficial effects on adult cancer pain. No benefits were 
   found for acupuncture (versus drug therapy or shame acupuncture), and the results 
   were inconsistent for massage therapy, transcutaneous electric nerve stimulation 
   (TENS), and Viscum album L plus cancer treatment. However, the evidence levels 
   for these interventions were low or moderate due to high risk of bias and/or 
   small sample size of primary studies. Conclusion. CAM may be beneficial for 
   alleviating cancer pain, but the evidence levels were found to be low or 
   moderate. Future large and rigor randomized controlled studies are needed to 
   confirm the benefits of CAM on adult cancer pain.
C1 Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China.
   Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Nanxiaojie, Dongzhimennei Avenue, Beijing 100700, China.
   Department of Nephrology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China.
   Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China.
   Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China.
   Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China.
   Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China.
   Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD MAY 13
PY 2014
VL 2014
IS 
BP 170396
EP 170396
DI 10.1155/2014/170396 
PG 0
UT PubMed:24817897
PM 24817897
DA 2014-05-13
ER

PT J
AU Deng, G
   Wong, WD
   Guillem, J
   Chan, Y
   Affuso, T
   Yeung, KS
   Coleton, M
   Sjoberg, D
   Vickers, A
   Cassileth, B
AF Deng, Gary
   Wong, W Douglas
   Guillem, Jose
   Chan, Yi
   Affuso, Theresa
   Yeung, K Simon
   Coleton, Marci
   Sjoberg, Daniel
   Vickers, Andrew
   Cassileth, Barrie
TI A phase II, randomized, controlled trial of acupuncture for reduction of 
SO Annals of surgical oncology
LA English
DT Journal Article
AB PURPOSE: Postoperative ileus (POI) prolongs hospital stay and increases risk of 
   postoperative complications. We conducted a randomized, sham-controlled trial to 
   evaluate whether acupuncture reduces POI more effectively than sham acupuncture. 
   METHODS: Colon cancer patients undergoing elective colectomy were randomized to 
   receive 30 min of true or sham acupuncture twice daily during their first 3 
   postoperative days. GI-3 (the later of the following two events: time that the 
   patient first tolerated solid food, AND time that the patient first passed flatus 
   OR a bowel movement) and GI-2 (the later of the following two events: time 
   patient first tolerated solid food AND time patient first passed a bowel 
   movement) were determined. Pain, nausea, vomiting, and use of pain medications 
   were evaluated daily for the first 3 postoperative days. RESULTS: Ninety patients 
   were randomized. Eighty-one received the allocated intervention: 39 in the true 
   acupuncture group and 42 in the sham acupuncture group, all evaluated for the 
   primary endpoint. The mean time to GI-3 was 149 h [standard deviation (SD) 71 h] 
   and 146 (SD 62 h) after surgery for the acupuncture group and the sham 
   acupuncture group (difference between means -2 h; 95 % confidence interval -31, 
   26; p = 0.9). No significant differences were found between groups for secondary 
   endpoints. CONCLUSIONS: True acupuncture as provided in this study did not reduce 
   POI more significantly than sham acupuncture. The study was limited by a standard 
   deviation much larger than expected, suggesting that a study with a larger sample 
   size might be required.
C1 Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. dengg@mskcc.org
NR 0
TC 0
SN 1534-468
EI 1068-926
J9 Ann Surg Oncol
PD NOV 29
PY 2012
VL 20
IS 4
BP 1164
EP 9
DI 10.1245/s10434-012-2759-7 
PG -1155
WC Acupuncture; Colectomy; adverse effects; Colonic Neoplasms; surgery; Female; Follow-Up Studies; Humans; Ileus; etiology; Length of Stay; Male; Middle Aged; Neoplasm Staging; Postoperative Complications; Prognosis; Prospective Studies; Survival Rate
UT PubMed:23188543
PM 23188543
DA 2012-11-29
ER

PT J
AU Binmoeller, KF
   Shah, JN
   Bhat, YM
   Kane, SD
AF Binmoeller, Kenneth F
   Shah, Janak N
   Bhat, Yasser M
   Kane, Steve D
TI Suck-ligate-unroof-biopsy by using a detachable 20-mm loop for the diagnosis and 
SO Gastrointestinal endoscopy
LA English
DT Journal Article
AB BACKGROUND: The diagnosis and therapy of subepithelial tumors (SETs) can be 
   challenging. OBJECTIVE: Proof-of-concept evaluation of the 
   suck-ligate-unroof-biopsy (SLUB) technique for small (<2 cm), non-pedunculated 
   SETs. DESIGN: Pilot feasibility study. SETTING: Tertiary-care referral center. 
   PATIENTS: Twenty-three patients (median age 60 years) meeting the inclusion 
   criteria after preliminary EUS. INTERVENTION: SET ligation was performed with a 
   detachable 20-mm loop deployed through an 18-mm diameter, soft, oblique, 
   transparent, cap attachment. The SLUB technique comprised (1) suction to draw the 
   SET into the cap; (2) ligation below the SET, confirmation by repeat EUS; (3) 
   unroofing of the overlying mucosa with a needle-knife; and (4) biopsy specimens 
   taken from the exposed tumor. MAIN OUTCOME MEASUREMENTS: Technical success, 
   histology and/or immunohistochemistry yield, adverse events, completeness of 
   resection. RESULTS: SLUB was attempted on 24 SETs and was technically successful 
   in all. Location was the stomach (n = 19), small bowel (n = 1), colon (n = 2), 
   and rectum (n = 2). Median size by EUS was 10 mm (range 6-15 mm). Biopsy 
   specimens provided an immunohistologic diagnosis in all cases: GI stromal tumor 
   (n = 5), leiomyoma (n = 8), carcinoid tumor (n = 5), Vanek's tumor (n = 2), 
   granuloma (n =1), and pancreatic heterotopia (n = 3). Follow-up endoscopy and EUS 
   in 13 patients showed well-healed scars with no residual tumor, including all 9 
   patients with premalignant neoplastic lesions. The only adverse event was 
   self-limited pain in 2 patients. LIMITATIONS: Single center, single operator, 
   small sample size. CONCLUSIONS: Loop ligation of small, non-pedunculated SETs is 
   feasible by using a cap attachment for suction. Unroofing after ligation is safe 
   and provides sufficient tissue for immunohistochemistry. Ligation combined with 
   unroofing appears to lead to complete ablation by ischemia and tumor enucleation.
C1 Paul May & Frank Stein Interventional Endoscopy Center, California Pacific Medical Center, San Francisco, California, USA.
   Paul May & Frank Stein Interventional Endoscopy Center, California Pacific Medical Center, San Francisco, California, USA.
   Paul May & Frank Stein Interventional Endoscopy Center, California Pacific Medical Center, San Francisco, California, USA.
   Paul May & Frank Stein Interventional Endoscopy Center, California Pacific Medical Center, San Francisco, California, USA.
NR 0
TC 0
SN 1097-677
EI 
J9 Gastrointest Endosc
PD NOV 19
PY 2013
VL 79
IS 5
BP 750
EP 5
DI 10.1016/j.gie.2013.09.028 
PG -745
WC Biopsy; instrumentation; Carcinoid Tumor; diagnostic imaging; Choristoma; diagnostic imaging; Endoscopy, Gastrointestinal; instrumentation; Endosonography; Feasibility Studies; Female; Gastrointestinal Neoplasms; pathology; Gastrointestinal Stromal Tumors; diagnostic imaging; Granuloma; diagnostic imaging; Humans; Leiomyoma; diagnostic imaging; Ligation; Male; Middle Aged; Pancreas; Pilot Projects; Retrospective Studies; Second-Look Surgery; Suction
UT PubMed:24238309
PM 24238309
DA 2013-11-19
ER

PT J
AU Huang, L
   Zhao, Y
   Xiang, M
AF Huang, Li
   Zhao, Yanqing
   Xiang, Minhong
TI Knowledge Mapping of Acupuncture for Cancer Pain: A Scientometric Analysis 
SO Journal of pain research
LA English
DT Journal Article
DE CiteSpace; acupuncture; cancer pain; knowledge mapping; scientometric analysis
AB OBJECTIVE: This study aimed to demonstrate the state of the present situation and 
   trends concerning the global use of acupuncture for cancer pain in the past 20 
   years. METHODS: Searched the Web of Science database from 2000 to 2019 related to 
   acupuncture for cancer pain, and then used CiteSpace to conduct scientometric 
   analysis to acquire the knowledge mapping. RESULTS: Yearly output has increased 
   year by year, and the growth rate has become faster after 2012. According to the 
   cluster analysis of institutions, authors, cited references, and keywords, 4, 4, 
   15, and 14 categories were obtained, respectively. The most productive countries, 
   institutions, and authors are the USA, Mem Sloan Kettering Cancer Center, and Mao 
   JJ, whose frequencies are 196, 24, and 17, respectively. However, the most 
   important of them are Australia, Univ. Maryland, and Bao T, owing to their 
   highest centrality, they are 0.90, 0.21, and 0.09 separately. Moreover, cited 
   references that contributed to the most co-citations are Crew KD (2010), however, 
   the most key cited reference is Roscoe JA (2003). Keywords such as acupuncture, 
   pain, breast cancer, palliative care, and quality of life are the most frequently 
   used. But auricular acupuncture is the crucial keyword. In the cluster analysis 
   of institutions, authors, cited references, and keywords, the more convincing 
   research categories are multiple myeloma, placebo effect, neck malignancies, and 
   early breast cancer, with S values of 0.990, 0.991, 0.990, and 0.923, 
   respectively. Therefore, they can be regarded as research hotspots in this field. 
   CONCLUSION: Based on the scientometric analysis in the past 20 years, the 
   knowledge mapping of the country, institution, author, cited reference, and the 
   keyword is gained, which has an important guiding significance for quickly and 
   accurately positioning the trend in this field.
C1 Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
   Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
   Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD FEB 13
PY 2021
VL 14
IS 
BP 343
EP 358
DI 10.2147/JPR.S292657 
PG 15
UT PubMed:33574698
PM 33574698
DA 2021-02-13
ER

PT J
AU You, X
   Wang, Y
   Wu, J
   Liu, Q
   Liu, Y
   Qian, Y
   Chen, J
   Tang, D
   Wang, D
AF You, Xiaolan
   Wang, Yuanjie
   Wu, Jian
   Liu, Qinghong
   Liu, Yanqing
   Qian, Yayun
   Chen, Jue
   Tang, Dong
   Wang, Daorong
TI Zusanli (ST36) Acupoint Injection with Neostigmine for Paralytic Postoperative 
SO Journal of Cancer
LA English
DT Journal Article
DE ST36 acupoint injection; ST36 acupucture; gastric cancer; paralytic postoperative ileus
AB Background: The Zusanli (ST36) acupoint has been associated with treatment of 
   various gastrointestinal conditions. There have been no studies of acupuncture 
   therapy for paralytic postoperative ileus (PPOI). Materials and methods: Patients 
   with PPOI following gastrectomy for gastric cancer were randomized to receive 
   ST36 acupoint injection with neostigmine, gluteal intramuscular injection with 
   1.0 mg neostigmine, ST36 acupuncture alone, or standard therapy. The main outcome 
   was the effectiveness rate for recovery of peristalsis. Secondary outcomes were 
   time to bowel sound recovery, time to first flatus, and time to first defecation. 
   Tertiary outcomes were drug-related adverse events, including abdominal pain, 
   diarrhea, nausea, vomiting, tearing, delirium, seizure, and anxiety. Results: 
   ST36 acupoint injection with neostigmine and gluteal intramuscular injection of 
   neostigmine gave a higher rate of peristalsis recovery, and the ST36 acupoint 
   injection group showed significantly higher total effectiveness rate than that of 
   the intramuscular injection group. These interventions gave significantly shorter 
   times to bowel sound recovery, shorter times to first flatus and first defecation 
   compared with ST36 acupuncture and standard post-operative therapy (P < 0.01). 
   ST36 acupoint injection group gave shorter time to bowel sound recovery, shorter 
   time to first flatus and first defecation than those of the intramuscular 
   injection group (P < 0.01). Drug-related adverse events in the intramuscular 
   injection group were more serious than in the ST36 acupoint injection group (P < 
   0.05). Conclusion: ST36 acupoint injection with neostigmine is safe and effective 
   for treatment of PPOI.
C1 Department of Integrated Traditional Chinese and Western Medicine, Medical College of Yangzhou University. Yangzhou, Jiangsu Province, China.
   Department of Gastrointestinal Surgery, Taizhou people's Hospital, Taizhou, 
   Department of Gastrointestinal Surgery, Taizhou people's Hospital, Taizhou, Jiangsu Province, China.
   Department of Gastrointestinal Surgery, Taizhou people's Hospital, Taizhou, Jiangsu Province, China.
   Department of Gastrointestinal Surgery, Taizhou people's Hospital, Taizhou, Jiangsu Province, China.
   Department of Integrated Traditional Chinese and Western Medicine, Medical College of Yangzhou University. Yangzhou, Jiangsu Province, China.
   Department of Integrated Traditional Chinese and Western Medicine, Medical College of Yangzhou University. Yangzhou, Jiangsu Province, China.
   Department of Integrated Traditional Chinese and Western Medicine, Medical College of Yangzhou University. Yangzhou, Jiangsu Province, China.
   Department of Gastrointestinal Surgery, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou JiangsuProvince, China.
   Department of Gastrointestinal Surgery, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou JiangsuProvince, China.
NR 0
TC 0
SN 1837-966
EI 1837-966
J9 J Cancer
PD JUL 22
PY 2018
VL 9
IS 13
BP 2266
EP 2274
DI 10.7150/jca.24767 
PG 8
UT PubMed:30026821
PM 30026821
DA 2018-07-22
ER

PT J
AU Menéndez-Aponte, Y Guzmán RM
   Turcott, Chaparro JG
   De, la Piedra Gómez A
   Sandoval, Eslava VM
   Tarditi, Ruiz GC
   Tapia, Garduño IM
   De, la Torre Madrid I
   Figueroa, IG
   Mohar, Betancourt A
   Arrieta, O
AF Menéndez-Aponte Y Guzmán, Raquel María
   Turcott Chaparro, Jenny Georgina
   De la Piedra Gómez, Amanda
   Sandoval Eslava, Victoria Margarita
   Tarditi Ruiz, Gina Carolina
   Tapia Garduño, Ilse Merari
   De la Torre Madrid, Irma
   Figueroa, Irma Gallegos
   Mohar Betancourt, Alejandro
   Arrieta, Oscar
TI Effect of complementary Integrative Oncology on anxiety, depression and quality 
SO Complementary therapies in clinical practice
LA English
DT Journal Article
DE Acupuncture; Cognitive behavior therapy; Integrative oncology; Lung cancer; Mindfulness; Thoracic cancer
AB PURPOSE: Thoracic-cancer (TC) patients have an extensive toll taken in terms of 
   health-related quality of life (HRQL). Integrative Oncology (IO) is recognized as 
   a valid complement to any Standard-Therapy treatment to improve outcomes in TC 
   patients. The objective of this pilot-study was to evaluate the effect of adding 
   IO (acupuncture, Cognitive-Behavior Therapy and mindfulness) in terms of 
   depression, anxiety and HRQL. METHODS: TC patients who attended the Thoracic 
   Oncology-Unit from July to September 2018 were invited to participate. A total of 
   16 patients were included in the study, 8 patients were required to attend 5 
   weekly sessions of IO and 8 patients were invited as controls. Anxiety, 
   depression and HRQL were measured at baseline and after completing 5 sessions of 
   IO or 5 weeks, using the HADS scale and the QLQ-C30 scale. RESULTS: A total of 8 
   patients in the IO group attended the 5 sessions and 8 patients were followed as 
   controls. Compliance with the therapies was high, none of the patients dropped 
   out from the study. A tendency for improvement in anxiety, fatigue, pain and 
   dyspnea was observed in patients attending IO, though not statistically 
   significant likely due to sample size. CONCLUSIONS: IO therapies are well 
   accepted among TC patients. Larger studies are necessary with robust sample sizes 
   to improve conclusions regarding outcome improvements.
C1 Integrative Oncology Center (CAAI), National Cancer Institute (INCan), Mexico. San Fernando, Num 22, sección 16, Tlalpan, CP, 14080, Ciudad de México, Mexico.
   Thoracic Oncology Unit and Laboratory of Personalized Medicine, National Cancer Institute (INCan), Mexico. San Fernando Num 22, sección 16, Tlalpan, CP, 14080,Ciudad de México, Mexico. 
   Integrative Oncology Center (CAAI), National Cancer Institute (INCan), Mexico. San Fernando, Num 22, sección 16, Tlalpan, CP, 14080, Ciudad de México, Mexico.
   Integrative Oncology Center (CAAI), National Cancer Institute (INCan), Mexico. San Fernando, Num 22, sección 16, Tlalpan, CP, 14080, Ciudad de México, Mexico.
   Integrative Oncology Center (CAAI), National Cancer Institute (INCan), Mexico. San Fernando, Num 22, sección 16, Tlalpan, CP, 14080, Ciudad de México, Mexico.
   Integrative Oncology Center (CAAI), National Cancer Institute (INCan), Mexico. San Fernando, Num 22, sección 16, Tlalpan, CP, 14080, Ciudad de México, Mexico.
   Integrative Oncology Center (CAAI), National Cancer Institute (INCan), Mexico. San Fernando, Num 22, sección 16, Tlalpan, CP, 14080, Ciudad de México, Mexico.
   Integrative Oncology Center (CAAI), National Cancer Institute (INCan), Mexico. San Fernando, Num 22, sección 16, Tlalpan, CP, 14080, Ciudad de México, Mexico.
   Integrative Oncology Center (CAAI), National Cancer Institute (INCan), Mexico. San Fernando, Num 22, sección 16, Tlalpan, CP, 14080, Ciudad de México, Mexico;Thoracic Oncology Unit and Laboratory of Personalized Medicine, National CancerInstitute (INCan), Mexico. San Fernando Num 22, sección 16, Tlalpan, CP, 14080,Ciudad de México, Mexico. 
   Thoracic Oncology Unit and Laboratory of Personalized Medicine, National Cancer Institute (INCan), Mexico. San Fernando Num 22, sección 16, Tlalpan, CP, 14080,Ciudad de México, Mexico. 
EM ogar@unam.mx
NR 0
TC 0
SN 1873-694
EI 
J9 Complement Ther Clin Pract
PD AUG 7
PY 2019
VL 36
IS 
BP 56
EP 63
DI 10.1016/j.ctcp.2019.05.003 
PG 7
WC Anxiety; therapy; Depression; therapy; Humans; Integrative Oncology; Pilot Projects; Quality of Life; psychology; Thoracic Neoplasms; psychology
UT PubMed:31383444
PM 31383444
DA 2019-08-07
ER

PT J
AU Carvalho, V
   Rangrej, SB
   Rathore, R
AF Carvalho, Victoria
   Rangrej, Shahid B
   Rathore, Rajni
TI The Benefits of Integrative Medicine for Pain Management in Oncology: A Narrative 
SO Cureus
LA English
DT Review
DE cancer pain management; chronic pain; integrative medicine; oncologic pain; pain
AB The aim of this evidence-based study is to narrate and evaluate the current 
   evidence on recommendations for practicing physicians and other healthcare 
   providers regarding integrative approaches to managing pain in patients with 
   cancer. This review will assess the guideline recommendations and analyze the 
   role of integrative medicine in addressing cancer pain in patients. The 
   literature search highlights relevant studies that will inform evidence-based 
   recommendations for practicing physicians, highlighting their relevance and 
   weaknesses. Acupuncture, massage, and hypnosis have intermediate-strength 
   evidence quality and are moderately recommended for various types of cancer pain. 
   Most of the evidence points to acupuncture being recommended for aromatase 
   inhibitor-related joint pain, hypnosis for procedural pain, and massage for 
   palliative care pain. Other practices with lower-quality evidence include yoga 
   and guided imagery with progressive muscle relaxation, mostly recommended for 
   general cancer pain or musculoskeletal pain. Additionally, music therapy is 
   recommended for procedural or surgical pain. Low-quality or inconclusive evidence 
   was found for other mind-body interventions or natural products. Similarly, there 
   is insufficient evidence to provide recommendations for pediatric patients. 
   Further research is required to enhance our understanding of the role of 
   integrative medicine interventions in caring for cancer patients.
C1 Medical School, Saint James School of Medicine, Arnos Vale, VCT.
   Anatomy/Research, Saint James School of Medicine, Arnos Vale, VCT.
   Pharmacology and Therapeutics, Saint James School of Medicine, Arnos Vale, VCT.
NR 0
TC 0
SN 2168-818
EI 2168-818
J9 Cureus
PD AUG 1
PY 2023
VL 15
IS 6
BP e41203
EP e41203
DI 10.7759/cureus.41203 
PG 1
UT PubMed:37525791
PM 37525791
DA 2023-08-01
ER

PT J
AU Huang, X
   Cai, H
   Zeng, W
   Zeng, X
   Xiao, X
   Liu, Y
   Xu, Y
   Liu, X
   Zhong, Q
AF Huang, Xiaomei
   Cai, Hanxue
   Zeng, Wen
   Zeng, Xueqin
   Xiao, Xinhong
   Liu, Yi
   Xu, Yanhong
   Liu, Xiaomei
   Zhong, Qinghua
TI WITHDRAWN: Effect of Auricular Point Acupressure Combined with Three-step 
SO Alternative therapies in health and medicine
LA English
DT Journal Article
AB This article has been withdrawn at the request of the author(s) and/or editor. 
   The Publisher apologizes for any inconvenience this may cause.
NR 0
TC 0
SN 
EI 1078-679
J9 Altern Ther Health Med
PD JUL 22
PY 2024
VL 0
IS 
BP 
EP 
DI 
PG 0
UT PubMed:39038354
PM 39038354
DA 2024-07-22
ER

PT J
AU Bas-Cutrina, F
   Loras, C
   Pardo, A
   Ballester-Clau, R
   Huertas, C
   Guarner-Argente, C
   Colan-Hernandez, J
   Consiglieri, CF
   Andujar, X
   Vilanova-Serra, M
   González-Huix, F
   Pardo-Grau, L
   Maisterra, S
   Ruiz-Ramírez, P
   Garcia-Sumalla, A
   Tebé, C
   Videla, S
   Gornals, JB
AF Bas-Cutrina, Francesc
   Loras, Carme
   Pardo, Albert
   Ballester-Clau, Raquel
   Huertas, Carlos
   Guarner-Argente, Carlos
   Colan-Hernandez, Juan
   Consiglieri, Claudia F
   Andujar, Xavi
   Vilanova-Serra, Magdalena
   González-Huix, Ferran
   Pardo-Grau, Laura
   Maisterra, Sandra
   Ruiz-Ramírez, Pablo
   Garcia-Sumalla, Albert
   Tebé, Cristian
   Videla, Sebastià
   Gornals, Joan B
TI Management of small subepithelial tumors by endoscopic banding without resection 
SO Gastrointestinal endoscopy
LA English
DT Journal Article
AB BACKGROUND AND AIMS: Endoscopic band ligation (EBL) without resection combined 
   with single-incision needle-knife (SINK) biopsy sampling may have a positive 
   impact on small GI subepithelial tumor (SET) management, but the method needs to 
   be tested. The aim was to evaluate the feasibility of this strategy in 
   small-sized SETs. METHODS: This prospective multicenter observational cohort 
   study in 7 centers included patients with SETs ≤15 mm (confirmed by EUS) between 
   March 2017 and March 2020. The primary outcome was clinical success at 4 weeks, 
   defined as complete SET disappearance on EUS. Secondary outcomes were long-term 
   (1-year) clinical success, technical difficulty level, clinical impact, yield 
   pathology, and safety. RESULTS: Of 273 patients screened, 122 (62.3% women; mean 
   age, 60.9 ± 13.2 years) were included with SETs (mean size, 9 ± 2.8 mm; gastric 
   location, 77%; superficial layer dependence, 63%). The primary endpoint was 
   achieved in 73.6% of patients (95% confidence interval [CI], 64.8-81.2). At the 
   1-year follow-up, the success rate was 68.4% (95% CI, 59.1-76.8). A favorable 
   clinical impact was observed in 97 cases (79.5%; 95% CI, 71.3-86.3). Pathology 
   diagnosis was known in 70%. Potentially malignant lesions were present in 24.7%. 
   The related adverse events rate was 4.1% (95% CI, 1.3-9.3; all mild: 2 bleeding, 
   2 abdominal pain). On multivariable analysis, the ≤10-mm SET group was associated 
   with a greater success rate (1 year, 87%; relative risk, 5.07; 95% CI, 2.63-9.8) 
   and clinical impact rate (92.7%; relative risk, 6.15; 95% CI, 2.72-13.93). 
   CONCLUSIONS: EBL plus SINK biopsy sampling seems to be feasible and safe, and it 
   may offer a favorable clinical impact in small-sized SETs. In particular, 
   SETs ≤10 mm are the best candidates. (Clinical trial registration number: 
   NCT03247231.).
C1 Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari de Bellvitge, Barcelona, Spain
   Bellvitge Biomedical Research Institute (IDIBELL),Barcelona, Spain
   Department of Clinical Sciences, School of Medicine and HealthSciences, University of Barcelona, Barcelona, Spain
   Digestive Diseases Unit,Hospital General de Granollers, Barcelona, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari Mútua de Terrassa, Barcelona, Spain
   Centro de Investigación Biomédica en Red deEnfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III,Madrid, Spain
   Faculty of Health Sciences, Universitat Oberta de Catalunya,Barcelona, Spain.
   Department of Digestive Diseases, Hospital Universitari Joan XXIII, Tarragona, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari Arnau de Vilanova, Lleida, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari Doctor Josep Trueta, Girona, Spain.
   Endoscopy Unit, Digestive Pathology Service, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari de Bellvitge, Barcelona, Spain
   Bellvitge Biomedical Research Institute (IDIBELL),Barcelona, Spain
   Department of Clinical Sciences, School of Medicine and HealthSciences, University of Barcelona, Barcelona, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari Mútua de Terrassa, Barcelona, Spain
   Centro de Investigación Biomédica en Red deEnfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III,Madrid, Spain.
   Department of Digestive Diseases, Hospital Universitari Joan XXIII, Tarragona, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari Arnau de Vilanova, Lleida, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari Doctor Josep Trueta, Girona, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari de Bellvitge, Barcelona, Spain
   Bellvitge Biomedical Research Institute (IDIBELL),Barcelona, Spain
   Department of Clinical Sciences, School of Medicine and HealthSciences, University of Barcelona, Barcelona, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari Mútua de Terrassa, Barcelona, Spain
   Centro de Investigación Biomédica en Red deEnfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III,Madrid, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari de Bellvitge, Barcelona, Spain
   Bellvitge Biomedical Research Institute (IDIBELL),Barcelona, Spain
   Department of Clinical Sciences, School of Medicine and HealthSciences, University of Barcelona, Barcelona, Spain.
   Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
   Statistics Advisory Service, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona,Spain.
   Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
   Department of Clinical Sciences, School of Medicine and Health Sciences, University ofBarcelona, Barcelona, Spain
   Clinical Research and Clinical Trial Unit(UICEC-IDIBELL), Hospital Universitari de Bellvitge, Barcelona, Spain.
   Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari de Bellvitge, Barcelona, Spain
   Bellvitge Biomedical Research Institute (IDIBELL),Barcelona, Spain
   Department of Clinical Sciences, School of Medicine and HealthSciences, University of Barcelona, Barcelona, Spain
   Faculty of Health Sciences,Universitat Oberta de Catalunya, Barcelona, Spain.
NR 0
TC 0
SN 1097-677
EI 
J9 Gastrointest Endosc
PD JUN 2
PY 2023
VL 98
IS 6
BP 911
EP 921.e8
DI 10.1016/j.gie.2023.05.057 
PG 1
WC Humans; Female; Middle Aged; Aged; Male; Stomach Neoplasms; pathology; Prospective Studies; Biopsy; methods; Gastrointestinal Neoplasms; surgery; Endoscopy
UT PubMed:37263361
PM 37263361
DA 2023-06-02
ER

PT J
AU Calcagni, N
   Gana, K
   Quintard, B
AF Calcagni, Nicolas
   Gana, Kamel
   Quintard, Bruno
TI A systematic review of complementary and alternative medicine in oncology: 
SO PloS one
LA English
DT Journal Article
AB BACKGROUND: Complementary and Alternative Medicines (CAM) are widely used by 
   cancer patients, despite limited evidence of efficacy. Manipulative and 
   body-based practices are some of the most commonly used CAM. This systematic 
   review evaluates their benefits in oncology. METHOD: A systematic literature 
   review was carried out with no restriction of language, time, cancer location or 
   type. PubMed, CENTRAL, PsycArticle, PsychInfo, Psychology and Behavioral Sciences 
   Collection and SOCindex were queried. Inclusion criteria were adult cancer 
   patients and randomized controlled trials (RCT) assessing manipulative and 
   body-based complementary practices on psychological and symptom outcomes. Effect 
   size was calculated when applicable. RESULTS: Of 1624 articles retrieved, 41 
   articles were included: massage (24), reflexology (11), acupressure (6). Overall, 
   25 studies showed positive and significant effects on symptom outcomes (versus 9 
   that did not), especially pain and fatigue. Mixed outcomes were found for quality 
   of life (8 papers finding a significant effect vs. 10 which did not) and mood (14 
   papers vs. 13). In most studies, there was a high risk of bias with a mean Jadad 
   score of 2, making interpretation of results difficult. CONCLUSION: These results 
   seem to indicate that manipulative CAM may be effective on symptom management in 
   cancer. However, more robust methodologies are needed. The methodological 
   requirements of randomized controlled trials are challenging, and more 
   informative results may be provided by more pragmatic study design.
C1 Laboratoire EA 4136 / INSERM UMR 1219, Team: Handicap Activity Cognition Health (HACH), Bordeaux, France.
   Univ. Bordeaux, Bordeaux, France.
   Univ. Bordeaux, Bordeaux, France.
   Laboratoire EA 4136 / INSERM UMR 1219, Team: Handicap Activity Cognition Health (HACH), Bordeaux, France.
   Univ. Bordeaux, Bordeaux, France.
NR 0
TC 0
SN 1932-620
EI 
J9 PLoS One
PD OCT 18
PY 2019
VL 14
IS 10
BP e0223564
EP e0223564
DI 10.1371/journal.pone.0223564 
PG 1
WC Combined Modality Therapy; methods; Complementary Therapies; methods; Humans; Medical Oncology; methods; Neoplasms; diagnosis; Psychotherapy; methods; Treatment Outcome
UT PubMed:31622362
PM 31622362
DA 2019-10-18
ER

PT J
AU Chen, M
   Zhao, H
   He, L
AF Chen, Menglin
   Zhao, Hua
   He, Ling
TI Comment On: "Acupuncture Treatment for Liver Cancer Pain: A Meta-Analysis".
SO Journal of surgical oncology
LA English
DT Letter
C1 School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, China.
   Gastroenterology Division, Jiangxi University of Chinese Medicine Affiliated 
   School of Basic Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
   School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, China.
   Gastroenterology Division, Jiangxi University of Chinese Medicine Affiliated 
NR 0
TC 0
SN 1096-909
EI 
J9 J Surg Oncol
PD SEP 20
PY 2024
VL 131
IS 2
BP 106
EP 107
DI 10.1002/jso.27918 
PG 1
UT PubMed:39300895
PM 39300895
DA 2024-09-20
ER

PT J
AU Zhao, J
   Li, J
   Zhou, J
   Li, M
AF Zhao, Junchao
   Li, Jiahui
   Zhou, Jinfeng
   Li, Ming
TI Comment on: "Acupuncture Treatment for Liver Cancer Pain: A Meta-Analysis".
SO Journal of surgical oncology
LA English
DT Letter
C1 Haiyan Hospital of Traditional Chinese Medicine, Jiaxing, China.
   Haiyan Hospital of Traditional Chinese Medicine, Jiaxing, China.
   Haiyan Hospital of Traditional Chinese Medicine, Jiaxing, China.
   The Central Hospital of Haining, Jiaxing, China.
NR 0
TC 0
SN 1096-909
EI 
J9 J Surg Oncol
PD DEC 3
PY 2024
VL 131
IS 5
BP 765
EP 766
DI 10.1002/jso.28035 
PG 1
UT PubMed:39623460
PM 39623460
DA 2024-12-03
ER

PT J
AU Wong, CHL
   Wong, W
   Lin, WL
   Au, DKY
   Wu, JCY
   Leung, TH
   Wu, IXY
   Chung, VCH
AF Wong, Charlene H L
   Wong, Wendy
   Lin, Wai Ling
   Au, David K Y
   Wu, Justin C Y
   Leung, Ting Hung
   Wu, Irene X Y
   Chung, Vincent C H
TI Prioritizing Chinese medicine clinical research questions in cancer palliative 
SO Health expectations : an international journal of public participation in health 
LA English
DT Journal Article
DE palliative care; patient participation; research priorities; stakeholder participation; traditional chinese medicine
AB BACKGROUND: Chinese medicine (CM) modalities, including acupuncture and Chinese 
   herbal medicine (CHM), are popular palliative interventions among patients with 
   cancer, but further clinical research is required to assess their effectiveness 
   and safety. OBJECTIVE: To prioritize top ten important CM clinical research 
   questions from patients with cancer, cancer survivors and caregivers' 
   perspectives via a face-to-face prioritization workshop in Hong Kong. METHODS: A 
   list of 25 CM clinical research questions for cancer palliative care, which were 
   identified from existing systematic reviews (SRs) and overview of SRs, was 
   presented to 17 participants (patients with cancer [n = 5], cancer survivors 
   [n = 6] and caregivers [n = 6]). The participants were then invited to establish 
   consensus on prioritizing top ten research questions. RESULTS: Among the top ten 
   priorities, five (50%) focused on acupuncture and related therapies, while five 
   (50%) were on CHM. The three most important research priorities were (i) manual 
   acupuncture plus opioids for relieving pain; (ii) CHM for improving quality of 
   life among patients receiving chemotherapy; and (iii) concurrent use of CHM plus 
   loperamide for reducing stomatitis. CONCLUSION: The top ten participant-endorsed 
   CM clinical research priorities for cancer palliative care can guide local 
   researchers on future direction. They can also inform local research funders on 
   patient-centred allocation of limited funding. Under limited research funding, 
   the most important co-prioritized research question from professional and patient 
   perspectives may be addressed first. PATIENT OR PUBLIC CONTRIBUTION: Patients 
   with cancer, cancer survivors and caregivers participated in conduct of the study 
   to prioritize CM clinical research questions.
C1 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.
   Jockey Club School of Public Health and Primary Care, The Chinese University of 
   National Institution of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China.
   Yat Hei Hong Kong Company Limited, Central, Hong Kong.
   Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
   Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
   Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.
   Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong.
   School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong 
   Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
   Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong.
   School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong 
NR 0
TC 0
SN 1369-762
EI 1369-651
J9 Health Expect
PD JUN 10
PY 2021
VL 24
IS 4
BP 1487
EP 1497
DI 10.1111/hex.13289 
PG 10
WC Caregivers; Humans; Medicine, Chinese Traditional; Neoplasms; drug therapy; Palliative Care; Quality of Life
UT PubMed:34107142
PM 34107142
DA 2021-06-10
ER

PT J
AU Armstrong, K
   Lanni, T Jr
   Anderson, MM
   Patricolo, GE
AF Armstrong, Karen
   Lanni, Thomas Jr
   Anderson, Maureen M
   Patricolo, Gail Elliott
TI Integrative medicine and the oncology patient: options and benefits.
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Acupuncture; Cancer; Integrative medicine; Naturopathic oncology; Oncology massage; Oncology patients
AB Cancer is a major public health problem, and cancer patients and survivors face 
   many physical and emotional challenges after the initial diagnosis, through 
   treatment, and in the post-treatment period. Different integrative medicine (IM) 
   modalities can be used to mitigate some of the physical issues that originate 
   from the cancer itself or the treatment and to promote well-being and emotional 
   health. Here, we discuss how an IM Department can function in a hospital system, 
   particularly with regard to oncology patients, the modalities appropriate for 
   oncology patients, how these modalities can benefit this patient population, and 
   the role of IM in cancer survivorship. A dedicated IM Department that works with 
   oncologists provides support and care for the whole person. These different 
   modalities work together to reduce pain, anxiety, and chemotherapy-induced nausea 
   and peripheral neuropathy, while promoting immune function and improving sleep, 
   range of motion, and an overall sense of well-being. However, each modality has 
   different contraindications for the oncology patient, and proper training is 
   required for safe and effective care. We illustrate how IM can be a valuable 
   component of the care of the oncology patient.
C1 Integrative Medicine, Beaumont Health, 3577 W. Thirteen Mile Road, Royal Oak, MI, 48073, USA.
   Oncology, Medicine, and Imaging, Beaumont Cancer Institute, Beaumont Health, Royal Oak, MI, 48073, USA.
   Integrative Medicine, Beaumont Health, 3577 W. Thirteen Mile Road, Royal Oak, MI, 48073, USA.
   Integrative Medicine, Beaumont Health, 3577 W. Thirteen Mile Road, Royal Oak, MI, 48073, USA. gail.elliottpatricolo@beaumont.org.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD FEB 6
PY 2018
VL 26
IS 7
BP 2267
EP 2273
DI 10.1007/s00520-017-4007-y 
PG 6
WC Humans; Integrative Medicine; methods; Medical Oncology; methods; Neoplasms; therapy
UT PubMed:29396594
PM 29396594
DA 2018-02-06
ER

PT J
AU Stoerkel, E
   Bellanti, D
   Paat, C
   Peacock, K
   Aden, J
   Setlik, R
   Walter, J
   Inman, A
AF Stoerkel, Erika
   Bellanti, Dawn
   Paat, Charmagne
   Peacock, Kimberly
   Aden, James
   Setlik, Robert
   Walter, Joan
   Inman, Alice
TI Effectiveness of a Self-Care Toolkit for Surgical Breast Cancer Patients in a 
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
DE anxiety; breast cancer; mind–body skills; pain; self-care; surgery
AB OBJECTIVE: To assess whether a self-care toolkit (SCT) provided to breast cancer 
   patients undergoing surgery could mitigate distress and lessen symptoms 
   associated with surgery. DESIGN: One hundred women with breast cancer, planning 
   to undergo initial surgery, were randomly assigned to either one of two groups: 
   treatment as usual (TAU; n = 49) or TAU with the addition of an SCT (n = 51). The 
   SCT contained an MP3 player with audio-files of guided mind-body techniques 
   (breathing, progressive muscle relaxation, meditation, guided imagery, and 
   self-hypnosis) and acupressure antinausea wristbands. Anxiety, pain, nausea, 
   sleep, fatigue, global health, and quality of life (QOL) were assessed using 
   validated outcome measures. Two inflammatory blood markers (erythrocyte 
   sedimentation rate [ESR] and C-reactive protein [CRP]) were measured serially. 
   Data were collected at baseline (T1), immediately before surgery (T2), within 
   10 h postoperatively (T3), and ∼2 weeks postsurgery (T4). SETTINGS: Numerous 
   studies have shown that psychological distress associated with a cancer diagnosis 
   can affect pain perception and QOL. RESULTS: Between T1 and T4, there were 
   significant between-group differences in Patient-Reported Outcomes Measurement 
   Information System (PROMIS)-57 scores of Pain Interference, Fatigue, and 
   Satisfaction with Social Roles, favoring the SCT group compared with TAU 
   (p = 0.005, p = 0.023, and p = 0.021, respectively). There was a significant mean 
   change in Defense and Veterans Pain Rating Scale (DVPRS) scores from T2 to T3, 
   with the SCT group having significantly smaller increases in postoperative pain 
   (p = 0.008) and in postoperative ESR (p = 0.0197) compared with the TAU group. 
   Clinically significant reductions in anxiety occurred in the SCT group during the 
   main intervention period. CONCLUSION: These results suggest that using the SCT in 
   the perioperative period decreased pain perceptions, fatigue, and inflammatory 
   cytokine secretion.
C1 1 Thought Leadership and Innovation Foundation , McLean, VA.
   1 Thought Leadership and Innovation Foundation , McLean, VA.
   1 Thought Leadership and Innovation Foundation , McLean, VA.
   2 Department of Epidemiology & Biostatistics, University of Texas Health San Antonio , San Antonio, TX.
   3 Brooke Army Medical Center , Fort Sam Houston, TX.
   3 Brooke Army Medical Center , Fort Sam Houston, TX.
   4 Samueli Institute , Alexandria, VA.
   3 Brooke Army Medical Center , Fort Sam Houston, TX.
NR 0
TC 0
SN 1557-770
EI 1075-553
J9 J Altern Complement Med
PD SEP 25
PY 2018
VL 24
IS 9-10
BP 916
EP 925
DI 10.1089/acm.2018.0069 
PG 9
WC Adult; Anxiety; therapy; Breast Neoplasms; surgery; Female; Hospitals, Military; Humans; Middle Aged; Military Personnel; Mind-Body Therapies; Pain Management; methods; Self Care; methods; Treatment Outcome
UT PubMed:30247967
PM 30247967
DA 2018-09-25
ER

PT J
AU Zhang, C
   Xia, C
   Zhang, X
   Li, W
   Miao, X
   Zhou, Q
AF Zhang, Chunpeng
   Xia, Chen
   Zhang, Xiaowen
   Li, Weimin
   Miao, Xuerong
   Zhou, Qinghui
TI Wrist-ankle acupuncture attenuates cancer-induced bone pain by regulating 
SO Chinese medicine
LA English
DT Journal Article
DE Cancer pain; Descending modulation; Electroacupuncture; Wrist–ankle acupuncture
AB BACKGROUND: Cancer-induced bone pain (CIBP) presents a multiple-mechanism of 
   chronic pain involving both inflammatory and neuropathic pain, and its 
   pathogenesis is closely related to endogenous descending system of pain control. 
   However, the action mechanism underlying the effects of wrist-ankle acupuncture 
   (WAA) versus electroacupuncture (EA) on CIBP remains unknown. METHODS: Thirty-two 
   Wistar rats were divided into sham, CIBP, EA-treated and WAA-treated groups. CIBP 
   was induced in rats of the latter three groups. Time courses of weight and 
   mechanical hyperalgesia threshold (MHT) were evaluated. After 6 days of EA or WAA 
   treatment, the expressions of 5-hydroxytryotamine type 3A receptor (5-HT(3A)R) 
   and μ-opioid receptor (MOR) in rostral ventromedial medulla (RVM) and/or spinal 
   cord, as well as the levels of 5-HT, β-endorphin, endomorphin-1 and endomorphin-2 
   in RVM and spinal cord, were detected. RESULTS: Injection of cancer cells caused 
   decreased MHT, which was attenuated by EA or WAA (P < 0.05). WAA had a quicker 
   analgesic effect than EA (P < 0.05). No significant difference of MOR in RVM was 
   found among the four groups. EA or WAA counteracted the cancer-driven 
   upregulation of 5-HT(3A)R and downregulation of MOR in spinal cord (P < 0.05), 
   and upregulation of 5-HT and downregulation of endomorphin-1 in both RVM and 
   spinal cord (P < 0.05). β-endorphin and endomorphin-2 in RVM and spinal cord 
   decreased in CIBP group compared with sham group (P < 0.05), but EA or WAA showed 
   no significant effect on them, although a tendency of increasing effect was 
   observed. CONCLUSION: WAA, similar to EA, alleviated mechanical hyperalgesia in 
   CIBP rats by suppressing the expressions of 5-HT and 5-HT(3A)R, and increasing 
   the expressions of MOR and endomorphin-1 in RVM-spinal cord pathway of the 
   descending pain-modulating system. However, WAA produced a quicker analgesic 
   effect than EA, the mechanisms of which need further investigation.
C1 School of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433 People's Republic of China.
   School of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433 People's Republic of China.
   School of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433 People's Republic of China.
   2Laboratory of Neuronal Network and Systems Biology, Shanghai Medical College, Fudan University, Shanghai, 200032 China. ISNI: 0000 0001 0125 2443. GRID:grid.8547.e
   Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, 225 Changhai Road, Shanghai, 200433 People's Republic ofChina.
   School of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433 People's Republic of China.
NR 0
TC 0
SN 1749-854
EI 1749-854
J9 Chin Med
PD FEB 12
PY 2020
VL 15
IS 
BP 13
EP 13
DI 10.1186/s13020-020-0289-y 
PG 0
UT PubMed:32042305
PM 32042305
DA 2020-02-12
ER

PT J
AU Li, ZQ
   Wang, XF
   Feng, C
   Fei, YT
   Liu, JP
AF Li, Zhi-Qiang
   Wang, Xue-Feng
   Feng, Cao
   Fei, Yu-Tong
   Liu, Jian-Ping
TI Global trends of acupuncture clinical research on analgesia from 2010 to 2023: a 
SO Frontiers in neurology
LA English
DT Journal Article
DE acupuncture; analgesia; bibliometric analysis; hotspots; visualization analysis
AB OBJECTIVE: Acupuncture, acknowledged as a potent non-pharmacological therapy, is 
   frequently employed to alleviate pain. Despite its widespread use, there has been 
   a lack of overarching bibliometric analysis of clinical research on acupuncture 
   analgesia. We aimed to summarize current patterns, hotspots, and development 
   trends in this field through bibliometric analysis. METHODS: This study evaluates 
   academic publications retrieved from the Web of Science database 
   (2010.01-2023.09) concerning acupuncture analgesia in clinical settings. All 
   primary and secondary studies on humans were included. To track global 
   developmental trends, we employed several software for analyzing annual 
   publication volumes, countries/regions, institutions, authors, cited authors, 
   journals, cited journals, references, and keywords and to draw collaborative 
   networks and reference co-citation network maps. RESULTS: The final search 
   encompassed 7,190 relevant studies, including 1,263 randomized controlled trials 
   (RCTs) and 1,293 systematic reviews and meta-analyses. The results indicated a 
   gradual increase in the number of annual publications on acupuncture analgesia in 
   clinical practice. Among countries and institutions, China (2,139) and Chengdu 
   University of Traditional Chinese Medicine (258) ranked first. Liang FR (89 
   articles) was the most prolific author, while MacPherson H (604) was the most 
   cited author. MEDICINE (455) was the most productive journal, and Pain 
   (2,473/0.20) ranked first in both the frequency and centrality of cited journals. 
   Notably, the most frequently cited reference was a systematic review of 
   individual patient data on acupuncture carried out for chronic pain that was 
   published by Vickers Andrew J in 2012 (156). Burst analysis identified frontier 
   research areas for 2010-2020, encompassing network meta-analysis, case reports, 
   dry needling, lumbar disc herniation, cancer, post-herpetic neuralgia, insomnia, 
   and bibliometric analysis. CONCLUSION: This study outlines current trends and 
   potential future research hotspots in clinical acupuncture analgesia over the 
   past decade. Findings emphasize the necessity for enhanced international 
   collaboration to improve research output and translation.
C1 Centre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
   Centre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
   Centre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
   Centre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
   Centre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
   The National Research Center in Complementary and Alternative Medicine (NAFKAM), 
NR 0
TC 0
SN 1664-229
EI 1664-229
J9 Front Neurol
PD APR 26
PY 2024
VL 15
IS 
BP 1368988
EP 1368988
DI 10.3389/fneur.2024.1368988 
PG 0
UT PubMed:38665996
PM 38665996
DA 2024-04-26
ER

PT J
AU Ahmed, A
   Thota, RS
   Bhatnagar, S
   Jain, P
   Ramanjulu, R
   Salins, N
   Chatterjee, A
   Bhattacharya, D
AF Ahmed, Arif
   Thota, Raghu S
   Bhatnagar, Sushma
   Jain, Parmanand
   Ramanjulu, Raghavendra
   Salins, Naveen
   Chatterjee, Aparna
   Bhattacharya, Dipasri
TI Indian Society for Study of Pain, Cancer Pain Special Interest Group Guidelines 
SO Indian journal of palliative care
LA English
DT Journal Article
DE Acupuncture; Indian Association of Palliative Care; Indian society for study of pain; cancer pain management; cancer pain management guidelines; cancer pain special interest group; cognitive behavioural therapy; complimentary therapy
AB The Indian Society for Study of Pain (ISSP), cancer pain Special Interest Group 
   (SIG) guidelines on complementary therapies for cancer pain in adults provides a 
   structured, stepwise approach which will help to improve the management of cancer 
   pain and to provide the patients with a minimally acceptable quality of life. The 
   guidelines have been developed based on the available literature and evidence, to 
   suit the needs, patient population, and situations in India. A questionnaire 
   based on the key elements of each sub drafts addressing certain inconclusive 
   areas where evidence was lacking, was made available on the ISSP website and 
   circulated by e-mail to all the ISSP and Indian Association of Palliative Care 
   members. We recommend that psychological interventions, including 
   psychoeducation, are useful and should be considered in patients with cancer pain 
   and psychological distress. Furthermore, physical and complementary treatment can 
   be used as an adjunctive therapy for patients with cancer pain.
C1 Department of Anaesthesia, Critical Care and Pain Management, CK Birla Hospital for Women, Gurugram, Haryana, India.
   Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
   Department of Onco-Anaesthesia and Palliative Medicine, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi,India.
   Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
   Department of Pain and Palliative Care, Cytecare Hospital, Bengaluru, Karnataka, India.
   Department of Palliative Medicine and Supportive Care, Manipal Comprehensive Cancer Care Centre, Kasturba Medical College, Manipal Academy of HigherEducation, Manipal, Karnataka, India.
   Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
   Department of Anaesthesiology, Critical Care and Pain, R.G. Kar Medical College, Kolkata, West Bengal, India.
NR 0
TC 0
SN 1998-373
EI 0973-107
J9 Indian J Palliat Care
PD SEP 3
PY 2020
VL 26
IS 2
BP 198
EP 202
DI 10.4103/0973-1075.285695 
PG 4
UT PubMed:32874033
PM 32874033
DA 2020-09-03
ER

PT J
AU Ashby, J
   Toveg, M
   Ye, H
   Rubin, LH
   Reddy, S
   Chao, MT
AF Ashby, Jennifer
   Toveg, Miria
   Ye, Helen
   Rubin, Lee Hullender
   Reddy, Sanjay
   Chao, Maria T
TI The Assessment and Treatment of Inpatient Cancer-Related Pain with Acupuncture: 
SO Medical acupuncture
LA English
DT Journal Article
DE Traditional Chinese Medicine; acupuncture; complementary and alternative medicine; inpatient; oncology; pain management
AB Background and Objective: Pain is a highly prevalent and distressing experience 
   of hospitalized patients with cancer, and undertreatment is a challenging issue. 
   Adding nonpharmacologic treatments such as acupuncture to conventional pain 
   management may help address a patient's total pain experience. A dearth of 
   acupuncture treatment guidelines exists, leaving individual practitioners to 
   develop treatments themselves. The aim of the work described in this report was 
   to develop a standardized clinical reference manual for East Asian Medicine (EAM) 
   assessment, diagnosis, and acupuncture treatment of cancer-related pain in 
   hospitalized patients with cancer. Design: The acupuncture manual was developed 
   based on: (1) a narrative review of existing literature on acupuncture and cancer 
   pain; (2) a review of acupuncture charting notes of more than 200 treatments 
   provided in an inpatient setting; and (3) meetings of an expert panel of senior 
   acupuncturists to reach consensus on a manual protocol. Results: The resulting 
   manual described diagnosis of patients based on EAM constitution, symptoms and 
   signs, and channel location of the cancer-related pain symptoms. The resulting 
   point selections for acupuncture treatment enables adaptability, reproducibility, 
   and individualized acupuncture treatment of cancer-related pain in hospitalized 
   patients with cancer. Conclusions: The manual fills a vital gap in the current 
   literature, and supports community- and hospital-based acupuncturists as a 
   standardized clinical reference. The manual provides guidance for cancer-related 
   pain management, using EAM acupuncture in hospitalized patients.
C1 Osher Center for Integrative Medicine, University of California-San Francisco, San Francisco, CA, USA.
   Osher Center for Integrative Medicine, University of California-San Francisco, San Francisco, CA, USA.
   Osher Center for Integrative Medicine, University of California-San Francisco, San Francisco, CA, USA.
   Osher Center for Integrative Medicine, University of California-San Francisco, San Francisco, CA, USA.
   Osher Center for Integrative Medicine, University of California-San Francisco, San Francisco, CA, USA.
   Division of Hospital Medicine, University of California-San Francisco, San 
   Osher Center for Integrative Medicine, University of California-San Francisco, San Francisco, CA, USA.
   Division of General Internal Medicine, University of California-San Francisco, 
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD MAR 8
PY 2022
VL 34
IS 1
BP 15
EP 23
DI 10.1089/acu.2021.0035 
PG 8
UT PubMed:35251434
PM 35251434
DA 2022-03-08
ER

PT J
AU Li, QY
   Yang, WX
   Yao, LQ
   Chen, H
   Li, ZR
   Gong, YB
   Shi, J
AF Li, Quan-Yao
   Yang, Wen-Xiao
   Yao, Li-Qiu
   Chen, Hong
   Li, Zhen-Rui
   Gong, Ya-Bin
   Shi, Jun
TI Exploring the Rules of Related Parameters in Transcutaneous Electrical Nerve 
SO Pain and therapy
LA English
DT Journal Article
DE Cancer; Cancer pain; Data mining; Parameters; Transcutaneous electrical nerve stimulation
AB INTRODUCTION: This study aims to investigate the regularity of related parameters 
   in the treatment of cancer pain using transcutaneous electrical nerve stimulation 
   (TENS). METHODS: A comprehensive literature search was conducted in databases 
   such as PubMed, Cochrane Library, Embase, Web of Science, OVID, CNKI, CBM, VIP, 
   and WANNGFANG from inception up to December 2022. A database was established, and 
   data mining techniques were applied to analyze the relevant TENS parameters. 
   RESULTS: A total of 27 articles were included, encompassing nine current 
   frequencies, four retention times, four treatment frequencies, and two wave 
   types. On the basis of the analysis of parameter association rules, the most 
   closely related parameter combination for clinical TENS in the treatment of 
   cancer pain was a current frequency of 2/100 Hz, a treatment frequency of once a 
   day, a retention time of 30 min, and the dilatational wave. Moreover, the study 
   involved 22 acupuncture points distributed along 13 meridians. According to the 
   analysis of acupuncture point association rules, Hegu (LI04), Zusanli (ST36), and 
   Sanyinjiao (SP06) were the most closely related acupuncture points and could be 
   used in combination for clinical TENS in cancer pain treatment. Furthermore, 
   cluster analysis was conducted on acupuncture points with a frequency ≥ 5, 
   resulting in three categories: the first category included Sanyinjiao (SP06), 
   Zusanli (ST36), Hegu (LI04), Jiaji point, and Neiguan (PC06); the second category 
   included Ashi point; and the third category included Back shu point. CONCLUSION: 
   In the treatment of cancer pain using TENS, it is recommended to use a current 
   frequency of 2/100 Hz, a treatment frequency of once a day, a retention time of 
   30 min, and the dilatational wave. The electrode positions were primarily 
   selected from Ashi point, Back shu point, Sanyinjiao (SP06), Zusanli (ST36), Hegu 
   (LI04), Jiaji point, and Neiguan (PC06) to achieve the best analgesic effect.
C1 Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai,200437, China.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai,200437, China.
   Jing'an District Hospital of Traditional Chinese Medicine, Shanghai, 200072, China.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai,200437, China.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai,200437, China.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai,200437, China. gongyabin@hotmail.com.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai,200437, China. shijundoctor@163.com.
NR 0
TC 0
SN 2193-651
EI 2193-823
J9 Pain Ther
PD AUG 14
PY 2023
VL 12
IS 6
BP 1355
EP 1374
DI 10.1007/s40122-023-00549-3 
PG 19
UT PubMed:37578681
PM 37578681
DA 2023-08-14
ER

PT J
AU Shainhouse, J
   Hwang, PSY
   Fontes, M
   Bao, T
AF Shainhouse, Jill
   Hwang, Pauline Sok Yin
   Fontes, Mark
   Bao, Ting
TI Integrative medicine in breast cancer survivorship care.
SO Annals of palliative medicine
LA English
DT Review
DE Integrative medicine; breast cancer; lifestyle; symptoms
AB Integrative medicine use is prevalent among breast cancer survivors to improve 
   lifestyle and manage symptoms associated with cancer or its treatment. This 
   review provides an overview of integrative therapies used for lifestyle 
   improvement and symptom management in breast cancer patients, including diet and 
   exercise recommendations, mind-body approaches including mindfulness-based 
   intervention, acupuncture, yoga, massage, and dietary supplements. A balanced 
   diet with an emphasis on plant-based foods and limited consumption of red meat, 
   processed meats, alcohol, and refined sugar is recommended for cancer patients 
   and survivors. Physical activity is also important, with recommendations of 30 
   minutes of moderate exercise daily, aiming for 150 minutes per week. Mind-body 
   approaches such as meditation, yoga have been shown to improve emotional 
   self-regulation, anxiety, depression, and other symptoms. Acupuncture has 
   demonstrated potential benefits for aromatase inhibitor-induced musculoskeletal 
   symptoms, hot flashes, peripheral neuropathy, and fatigue. Massage may help 
   address pain, anxiety, stress, and improve quality of life (QoL). Supplement use 
   should be approached with caution, especially during active treatment, due to 
   potential interactions with cancer therapies. The review highlights the role of 
   specialized integrative medicine practitioners, such as naturopathic doctors and 
   acupuncturists, in safely incorporating these therapies into standard cancer 
   care. This collaborative approach supports survivors' diverse needs and empowers 
   them to actively participate in their recovery, ultimately improving health 
   outcomes and QoL. Integrative therapy programs within cancer care institutions 
   can provide structure, guidance, and support for patients to safely incorporate 
   these modalities into their treatment and recovery plans.
C1 Integrative Cancer Care, Insight Naturopathic Clinic, Toronto, ON, Canada.
   Internal Medicine, Nanjing University of Chinese Medicine, Hillgreen Oncology Acupuncture & Herbs, Toronto, ON, Canada.
   Integrative Cancer Care, Insight Naturopathic Clinic, Toronto, ON, Canada.
   Medical Oncology Department, Dana-Farber Cancer Institute, Boston, MA, USA.
NR 0
TC 0
SN 2224-583
EI 
J9 Ann Palliat Med
PD JUN 13
PY 2025
VL 14
IS 3
BP 283
EP 294
DI 10.21037/apm-24-176 
PG 11
WC Humans; Breast Neoplasms; therapy; Integrative Medicine; methods; Female; Cancer Survivors; psychology; Quality of Life; Mind-Body Therapies; Complementary Therapies
UT PubMed:40511571
PM 40511571
DA 2025-06-13
ER

PT J
AU Cassileth, BR
AF Cassileth, Barrie R
TI Psychiatric benefits of integrative therapies in patients with cancer.
SO International review of psychiatry (Abingdon, England)
LA English
DT Review
AB Integrative oncology uses non-pharmacological adjuncts to mainstream care to 
   manage physical, emotional, and psychological symptoms experienced by cancer 
   survivors. Depression, anxiety, fatigue and pain are among the common, often 
   burdensome symptoms that can occur in clusters, deplete patient morale, interfere 
   with treatment plans, and hamper recovery. Patients already seek various 
   modalities on their own to address a broad range of problems. Legitimate 
   complementary therapies offered at major cancer institutions improve quality of 
   life, speed recovery, and optimize patient support. They also augment the 
   benefits of psychiatric interventions, due to their ability to increase 
   self-awareness and improve physical and psychological conditioning. Further, 
   these integrated therapies provide lifelong tools and develop skills that 
   patients use well after treatment to develop self-care regimens. The active 
   referral of patients to integrative therapies achieves three important 
   objectives: complementary care is received from therapists experienced in working 
   with cancer patients, visits become part of the medical record, allowing 
   treatment teams to guide individuals in maximizing benefit, and patients are 
   diverted from useless or harmful 'alternatives.' We review the reciprocal 
   physical and psychiatric benefits of exercise, mind-body practices, massage, 
   acupuncture, and music therapy for cancer survivors, and suggest how their use 
   can augment mainstream psychiatric interventions.
C1 Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center , New York , USA.
NR 0
TC 0
SN 1369-162
EI 
J9 Int Rev Psychiatry
PD APR 11
PY 2014
VL 26
IS 1
BP 114
EP 27
DI 10.3109/09540261.2013.838153 
PG -87
WC Complementary Therapies; methods; Humans; Mental Disorders; etiology; Neoplasms; psychology; Survivors; psychology
UT PubMed:24716505
PM 24716505
DA 2014-04-11
ER

PT J
AU Paley, CA
   Bennett, MI
   Johnson, MI
AF Paley, Carole A
   Bennett, Michael I
   Johnson, Mark I
TI Acupuncture for cancer-induced bone pain?
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB Bone pain is the most common type of pain in cancer. Bony metastases are common 
   in advanced cancers, particularly in multiple myeloma, breast, prostate or lung 
   cancer. Current pain-relieving strategies include the use of opioid-based 
   analgesia, bisphosphonates and radiotherapy. Although patients experience some 
   pain relief, these interventions may produce unacceptable side-effects which 
   inevitably affect the quality of life. Acupuncture may represent a potentially 
   valuable adjunct to existing strategies for pain relief and it is known to be 
   relatively free of harmful side-effects. Although acupuncture is used in 
   palliative care settings for all types of cancer pain the evidence-base is sparse 
   and inconclusive and there is very little evidence to show its effectiveness in 
   relieving cancer-induced bone pain (CIBP). The aim of this critical review is to 
   consider the known physiological effects of acupuncture and discuss these in the 
   context of the pathophysiology of malignant bone pain. The aim of future research 
   should be to produce an effective protocol for treating CIBP with acupuncture 
   based on a sound, evidence-based rationale. The physiological mechanisms 
   presented in this review suggest that this is a realistic objective.
C1 Faculty of Health, Leeds Metropolitan University, Leeds, UK.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD JUL 30
PY 2011
VL 2011
IS 
BP 671043
EP 671043
DI 10.1093/ecam/neq020 
PG 0
UT PubMed:21799687
PM 21799687
DA 2011-07-30
ER

PT J
AU Lee, B
   Kwon, CY
   Lee, HW
   Nielsen, A
   Wieland, LS
   Kim, TH
   Birch, S
   Alraek, T
   Lee, MS
AF Lee, Boram
   Kwon, Chan-Young
   Lee, Hye Won
   Nielsen, Arya
   Wieland, L Susan
   Kim, Tae-Hun
   Birch, Stephen
   Alraek, Terje
   Lee, Myeong Soo
TI Different Outcomes According to Needling Point Location Used in Sham Acupuncture 
SO Cancers
LA English
DT Review
DE acupuncture therapy; cancer pain; cancer-related pain; placebo; sham acupuncture
AB Numerous acupuncture studies have been conducted on cancer-related pain; however, 
   its efficacy compared to sham acupuncture remains controversial. We confirmed 
   whether the outcome of acupuncture differs according to the needling points of 
   sham acupuncture for cancer-related pain. We searched 10 databases on 23 May 2023 
   to screen acupuncture trials using sham acupuncture or waiting list as controls 
   for cancer-related pain. Sham acupuncture was classified into two types, 
   depending on whether the needling was applied at the same locations as verum 
   acupuncture (SATV) or not (SATS). A network meta-analysis (NMA) was performed on 
   the basis of a frequentist approach to assess pain severity. Eight studies (n = 
   574 participants) were included in the review, seven of which (n = 527 
   participants) were included in the NMA. The pain severity was not significantly 
   different between SATV and verum acupuncture, but verum acupuncture significantly 
   improved pain severity compared to SATS. The risk of bias affecting the 
   comparisons between the verum and sham acupuncture was generally low. Previous 
   acupuncture trials for cancer-related pain showed differing outcomes of sham and 
   verum acupuncture, depending on the needling points of sham acupuncture. The 
   application of SATV cannot be considered a true placebo, which leads to an 
   underestimation of the efficacy of verum acupuncture.
C1 KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
   Department of Oriental Neuropsychiatry, Dong-Eui University College of Korean Medicine, Busan 47227, Republic of Korea.
   KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
   Department of Family Medicine & Community Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
   Center for Integrative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
   Korean Medicine Clinical Trial Center, Korean Medicine Hospital, Kyung Hee University, Seoul 02447, Republic of Korea.
   Kristiania University College, School of Health Sciences, 0317 Oslo, Norway.
   Kristiania University College, School of Health Sciences, 0317 Oslo, Norway.
   Department of Community Medicine, Faculty of Health Sciences, National Research 
   KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
NR 0
TC 0
SN 2072-669
EI 2072-669
J9 Cancers (Basel)
PD DEC 23
PY 2023
VL 15
IS 24
BP 
EP 
DI 10.3390/cancers15245875 
PG 0
UT PubMed:38136419
PM 38136419
DA 2023-12-23
ER

PT J
AU Vinjamury, SP
   Li, JT
   Hsiao, E
   Huang, C
   Hawk, C
   Miller, J
   Huang, Y
AF Vinjamury, Sivarama Prasad
   Li, Ju-Tzu
   Hsiao, Eric
   Huang, Calen
   Hawk, Cheryl
   Miller, Judith
   Huang, Yuhong
TI Effects of acupuncture for cancer pain and quality of life - a case series.
SO Chinese medicine
LA English
DT Journal Article
AB BACKGROUND: Many cancer patients seek complementary and alternative medicine 
   (CAM) including acupuncture to manage their cancer-related symptoms or side 
   effects of treatments. Acupuncture is used to manage cancer pain and improve 
   quality of life (QoL). This study aimed to conduct a preliminary study on a case 
   series to evaluate the feasibility of acupuncture for treating cancer pain and to 
   collect preliminary data on the effectiveness of acupuncture in treating cancer 
   pain and improving QoL. METHODS: A semi-standardized acupuncture treatment 
   comprising one to three treatment sessions (20-30 minutes per session) per week 
   for 8 weeks was provided by four licensed acupuncturists, who had more than 5 
   years of clinical experience, at the University Health Center. The European 
   Organization for Research and Treatment of Cancer Quality of Life Questionnaire 
   (EORTC QLQ-C3) and a visual analogue scale (VAS) for pain rating were used as the 
   outcome measures to assess pain and QoL. Data were collected at baseline, 
   immediately after 2, 4, 6, and 8 weeks of treatment and at 4 weeks after 
   treatment completion (week 12). RESULTS: Two males and five females with a median 
   age of 66 years (range: 44-71 years) completed the study. For the VAS, the 
   percentage of improvement ranged between 18% and 95%. The baseline mean raw score 
   was reduced from 51 mm to 36 mm at the end of week 8 and to 23 mm at the end of 
   week 12. The percentage of overall QoL improvement ranged between 20% and 100%. 
   The mean raw score for QoL improved with time. The baseline score was increased 
   from 55 to 69 at the end of treatment (week 8) and to 73 after the follow-up 
   (week 12). CONCLUSIONS: This pilot study on a case series showed that acupuncture 
   might be beneficial for reducing pain and improving QoL in cancer patients.
C1 Department of Fundamental Principles, Southern California University of Health Sciences, California, USA. sivaramavinjamury@scuhs.edu.
NR 0
TC 0
SN 1749-854
EI 1749-854
J9 Chin Med
PD JUL 31
PY 2013
VL 8
IS 1
BP 15
EP 15
DI 10.1186/1749-8546-8-15 
PG 0
UT PubMed:23895044
PM 23895044
DA 2013-07-31
ER

PT J
AU Hamachi, A
   Matriz, J
   Fukui, J
AF Hamachi, April
   Matriz, Jobel
   Fukui, Jami
TI The use of complementary and alternative medicine among cancer patients in 
SO BMC complementary medicine and therapies
LA English
DT Journal Article
DE Alternative; CAM; Cancer symptom management; Complementary; Integrative medicine
AB Complementary and alternative medicine (CAM) are medical products and practices 
   that are not part of standard medical care. Various studies demonstrate benefits 
   of CAM use in alleviating cancer related side effects. However, data involving 
   the use of CAM therapies among cancer patients is limited. Hawaii has a unique 
   and diverse population and trends in CAM use could reveal important aspects of 
   cancer care. We distributed questionnaires to various cancer treatment centers 
   across Oahu. The questionnaires were optional and anonymous. We evaluated 126 
   questionnaires and analyzed CAM use. We collected participant data including: 
   cancer type, treatments used (surgery, radiation, chemotherapy) and patient 
   demographics (age, gender, ethnicity, income, religion). We found that at least 
   one CAM therapy is used by a majority of patients 72/126 (57.1%), while 54 
   (42.9%) do not use any CAM therapy. Among the CAM therapies, meditation and 
   herbal supplements were most commonly used 26 (36.1%), followed by massage 25 
   (34.7%), yoga 18 (25%), CBD 17 (23.6%), THC 16 (22.2%), and acupuncture 14 
   (19.4%). Stress reduction was the most common symptom benefit noted for 
   meditation, herbal supplement, massage, and yoga. Anxiety was another symptom 
   benefit reported for meditation. THC and CBD are used for sleep, however, CBS was 
   also used for pain reduction together with acupuncture. Among the patients who 
   use CAM therapy (n = 72), 80.6% are female (n = 58) while only 8.3% are male 
   (n = 6). Furthermore only, 18.3% (n = 23) of our respondents have spoken to a 
   clinician about CAM. We discovered that stress reduction is a symptom benefit 
   associated with the most commonly used CAM therapies by cancer patients in 
   Hawaii. Other symptom benefits involve anxiety, pain, and sleep. The modalities 
   utilized were similar to nonpharmacologic therapies recommended by the NCCN 
   guidelines for cancer survivorship, with the exception of herbal supplements. 
   There is a lack of physician discussion regarding CAM use, which could impact the 
   cancer burden in Hawaii.
C1 John A. Burns School of Medicine, University of Hawaii, Honolulu, USA. ahamachi@hawaii.edu.
   John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
   University of Hawaii Cancer Center, Honolulu, USA.
NR 0
TC 0
SN 2662-767
EI 
J9 BMC Complement Med Ther
PD MAY 9
PY 2025
VL 25
IS 1
BP 167
EP 167
DI 10.1186/s12906-025-04912-z 
PG 0
WC Humans; Complementary Therapies; statistics & numerical data; Hawaii; Male; Female; Neoplasms; therapy; Middle Aged; Adult; Aged; Surveys and Questionnaires; Young Adult; Aged, 80 and over
UT PubMed:40340689
PM 40340689
DA 2025-05-09
ER

PT J
AU Burnstock, G
AF Burnstock, G
TI Purinergic signalling in the lower urinary tract.
SO Acta physiologica (Oxford, England)
LA English
DT Review
AB The aim of this review is to describe the conceptual steps contributing to our 
   current knowledge of purinergic signalling and to consider its involvement in the 
   physiology and pathophysiology of the lower urinary tract. The voiding reflex 
   involves ATP released as a cotransmitter with acetylcholine from parasympathetic 
   nerves supplying the bladder and ATP released from urothelial cells during 
   bladder distension to initiate the voiding reflex via P2X3 receptors on 
   suburothelial low threshold sensory nerve fibres. This mechanosensory 
   transduction pathway also participates, via high threshold sensory nerve fibres, 
   in the initiation of pain in bladder and ureter. Treatment of prostate and 
   bladder cancer with ATP is effective against the primary tumours in animal models 
   and human cell lines, via P2X5 and P2X7 receptors, and also improves the systemic 
   symptoms associated with advanced malignancy. Acupuncture is widely used for the 
   treatment of urinary disorders, and a purinergic hypothesis is discussed for the 
   underlying mechanism.
C1 Autonomic Neuroscience Centre, University College Medical School, London, UK. g.burnstock@ucl.ac.uk
NR 0
TC 0
SN 1748-171
EI 
J9 Acta Physiol (Oxf)
PD NOV 28
PY 2012
VL 207
IS 1
BP 40
EP 52
DI 10.1111/apha.12012 
PG 12
WC Animals; Humans; Male; Prostate; innervation; Prostatic Neoplasms; physiopathology; Receptors, Purinergic; physiology; Signal Transduction; physiology; Ureter; innervation; Urinary Bladder; innervation; Urinary Bladder Neoplasms; physiopathology
UT PubMed:23176070
PM 23176070
DA 2012-11-28
ER

PT J
AU Zhou, X
   Zhang, J
   Jiang, L
   Zhang, S
   Gu, Y
   Tang, J
   Pu, T
   Quan, X
   Chi, H
   Huang, S
AF Zhou, Xuancheng
   Zhang, Jieying
   Jiang, Lai
   Zhang, Shengke
   Gu, Yuheng
   Tang, Jingyi
   Pu, Tong
   Quan, Xiaomin
   Chi, Hao
   Huang, Shangke
TI Therapeutic efficacy of acupuncture point stimulation for stomach cancer pain: a 
SO Frontiers in neurology
LA English
DT Journal Article
DE acupuncture point stimulation; meta-analysis; stomach cancer pain; therapeutic efficacy; traditional Chinese medicine
AB PURPOSE: In recent years, traditional Chinese medicine has received widespread 
   attention in the field of cancer pain treatment. This meta-analysis is the first 
   to evaluate the effectiveness and safety of acupuncture point stimulation in the 
   treatment of stomach cancer pain. METHODS: For this systematic review and 
   meta-analysis, we searched PubMed, Web of Science, Cochrane Library, Embase, 
   WANFANG, China National Knowledge Infrastructure (CNKI), and Chinese Journal of 
   Science and Technology (VIP) databases as well as forward and backward citations 
   to studies published between database creation to July 27, 2023. All randomized 
   controlled trials (RCTs) on acupuncture point stimulation for the treatment of 
   patients with stomach cancer pain were included without language restrictions. We 
   assessed all outcome indicators of the included trials. The evidence from the 
   randomized controlled trials was synthesized as the standardized mean difference 
   (SMD) of symptom change. The quality of the evidence was assessed using the 
   Cochrane Risk of Bias tool. This study is registered on PROSPERO under the number 
   CRD42023457341. RESULTS: Eleven RCTs were included. The study included 768 
   patients, split into 2 groups: acupuncture point stimulation treatment group (n 
   = 406), medication control group (n = 372). The results showed that treatment was 
   more effective in the acupuncture point stimulation treatment group than in the 
   medication control group (efficacy rate, RR = 1.63, 95% CI 1.37 to 1.94, p 
   < 0.00001), decreasing in NRS score was greater in acupuncture point stimulation 
   treatment group than in the medication control group (SMD = -1.30, 95% CI -1.96 
   to -0.63, p < 0.001). SYSTEMATIC REVIEW REGISTRATION: 
   https://clinicaltrials.gov/, identifier CRD42023457341.
C1 Clinical Medical College, Southwest Medical University, Luzhou, China.
   First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
   National Clinical Research Center for Chinese Medicine Acupuncture and 
   Clinical Medical College, Southwest Medical University, Luzhou, China.
   Clinical Medical College, Southwest Medical University, Luzhou, China.
   Clinical Medical College, Southwest Medical University, Luzhou, China.
   Clinical Medical College, Southwest Medical University, Luzhou, China.
   College of Acupuncture and Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China.
   Beijing University of Chinese Medicine Second Affiliated Dong Fang Hospital, Beijing, China.
   Clinical Medical College, Southwest Medical University, Luzhou, China.
   Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
NR 0
TC 0
SN 1664-229
EI 1664-229
J9 Front Neurol
PD APR 19
PY 2024
VL 15
IS 
BP 1334657
EP 1334657
DI 10.3389/fneur.2024.1334657 
PG 0
UT PubMed:38638316
PM 38638316
DA 2024-04-19
ER

PT J
AU Zhang, J
   Wu, W
   Ren, Y
   Yuan, Y
   Jia, L
AF Zhang, Junning
   Wu, Weizhen
   Ren, Yuehan
   Yuan, Yi
   Jia, Liqun
TI Electroacupuncture for the treatment of cancer pain: a systematic review and 
SO Frontiers in pain research (Lausanne, Switzerland)
LA English
DT Review
DE cancer pain; complementary and alternative medicine; electroacupuncture; meta-analysis; rct; systematic review
AB OBJECTIVE: This paper aims to review the current evidence on electroacupuncture 
   as an effective and safe therapy for cancer pain management. METHODS: Five 
   databases were searched from their inception through November 11, 2022. Only the 
   randomized controlled trials that meet the eligibility criteria were finally 
   included in the study. Literature screening and data extraction were performed 
   independently by two reviewers, and RevMan 5.3 used for meta-analysis. RESULTS: A 
   total of 17 RCTs met our inclusion criteria. We used 8 indicators to estimate the 
   meta-analysis results, most of which proved statistically significant, including 
   VAS scores, NRS scores, and KPS scores. To be specific, VAS scores (MD = -1.41, 
   95% CI: -2.42 to -0.41, P = 0.006) and NRS scores (MD = -1.19, 95% CI: -1.72 to 
   -0.66, P < 0.0001) were significantly lower in the treatment group compared to 
   the control group. The treatment group's KPS scores (MD = 5.48, 95% CI: 3.27 to 
   7.69, P < 0.00001) were higher than those of the control group. Also, in the 
   treatment group, the number of burst pain (MD = -2.66, 95% CI: -3.32 to -1.99, 
   P < 0.00001) and side effect rates (RR = 0.51, 95% CI: 0.39 to 0.67, P < 0.00001) 
   greatly reduced, while the response rate (RR = 1.17, 95% CI: 1.09 to 1.26, 
   P < 0.0001) significantly increased compared to the control group. CONCLUSION: 
   This study demonstrates the advantages of electroacupuncture in the treatment of 
   cancer pain. Meanwhile, rigorous RCTs should be designed and conducted in the 
   future to further demonstrate the exact efficacy of electroacupuncture. 
   SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/, identifier 
   CRD42022376148.
C1 Graduate School, Beijing University of Chinese Medicine, Beijing, China.
   Department of Oncology of Integrative Chinese and Western Medicine, China-Japan 
   Graduate School, Beijing University of Chinese Medicine, Beijing, China.
   Graduate School, Beijing University of Chinese Medicine, Beijing, China.
   Graduate School, Beijing University of Chinese Medicine, Beijing, China.
   Department of Oncology of Integrative Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing, China.
NR 0
TC 0
SN 2673-561
EI 2673-561
J9 Front Pain Res (Lausanne)
PD MAY 31
PY 2023
VL 4
IS 
BP 1186506
EP 1186506
DI 10.3389/fpain.2023.1186506 
PG 0
UT PubMed:37255718
PM 37255718
DA 2023-05-31
ER

PT J
AU Lee, SM
   Choi, HC
   Hyun, MK
AF Lee, Seong Min
   Choi, Ho Cheol
   Hyun, Min Kyung
TI An Overview of Systematic Reviews: Complementary Therapies for Cancer Patients.
SO Integrative cancer therapies
LA English
DT Journal Article
DE AMSTAR2; Assessing the Methodological Quality of Systematic Reviews 2; Complementary therapies; cancer
AB Introduction: This article critically examines the systematic reviews (SR) and 
   meta-analysis (MA) of complementary therapies for cancer patients to appraise the 
   evidence level, and offers suggestions for future research and practice. Methods: 
   The Cochrane Library and MEDLINE were searched from their inception to January 
   2018, to identify SR and MA of complementary therapies available for cancer 
   patients. Final selected SR and MA were methodologically evaluated for their 
   quality by applying the Assessing the Methodological Quality of Systematic 
   Reviews 2 (AMSTAR2) instrument. Data extraction and risk of quality assessments 
   were performed by 2 independent reviewers. Results: A total of 104 studies were 
   included in the analysis. The majority of the individual clinical trials included 
   in the SR and MA were performed in China (48%) and the United States (26.9%). 
   Breast cancer was the most studied cancer type (25%), and acupuncture was the 
   most studied intervention (21%). Side effects of cancer such as pain, depression, 
   and fatigue were effectively managed with complementary therapies. The 
   methodologically problematic items included not listing the excluded studies and 
   lack of protocol or protocol registration. Conclusions: With increasing interest 
   in research, complementary therapies appear to be beneficial in reducing side 
   effects and raising the quality of life of cancer patients. Complementary 
   therapies have generally been studied for all cancers, with acupuncture being the 
   most researched, regardless of the cancer type. Since AMSTAR2 is a stricter 
   assessment tool than before, future studies need to consider the risk of 
   methodological bias with caution and discuss appropriate overall quality 
   assessment tools.
C1 College of Korean Medicine, Dongguk University, Gyeongju, Republic of Korea.
   College of Korean Medicine, Dongguk University, Gyeongju, Republic of Korea.
   Department of Preventive Medicine, College of Korean Medicine, Dongguk University, Gyeongju, Republic of Korea.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD DEC 27
PY 2019
VL 18
IS 
BP 1534735419890029
EP 1534735419890029
DI 10.1177/1534735419890029 
PG 1
WC China; Complementary Therapies; methods; Humans; Neoplasms; therapy; Quality of Life
UT PubMed:31876212
PM 31876212
DA 2019-12-27
ER

PT J
AU Zhang, X
   Qiu, H
   Li, C
   Cai, P
   Qi, F
AF Zhang, Xiaoyi
   Qiu, Hua
   Li, Chensheng
   Cai, Pingping
   Qi, Fanghua
TI The positive role of traditional Chinese medicine as an adjunctive therapy for 
SO Bioscience trends
LA English
DT Review
DE Chinese herbal medicines; Traditional Chinese Medicine (TCM); acupuncture; anti-cancer therapy-related adverse reactions and complications; cancer-related symptoms
AB Traditional Chinese medicine (TCM), especially Chinese herbal medicines and 
   acupuncture, has been traditionally used to treat patients with cancers in China 
   and other East Asian countries. Numerous studies have indicated that TCM not only 
   alleviates the symptoms (e.g., fatigue, chronic pain, anorexia/cachexia, and 
   insomnia) of patients with cancer and improves their quality of life (QOL) but 
   also diminishes adverse reactions and complications caused by chemotherapy, 
   radiotherapy, or targeted-therapy. Therefore, Chinese herbal medicines and 
   acupuncture and other alternative therapies need to be understood by TCM 
   physicians and other health care providers. This review mainly summarizes the 
   experimental results and conclusions from literature published since 2010, and a 
   search of the literature as been performed in the PubMed, MEDLINE, Web of 
   Science, Scopus, Springer, ScienceDirect, and China Hospital Knowledge Database 
   (CHKD) databases. Some Chinese herbal medicines (e.g., Panax ginseng, Panax 
   quinquefolius, Astragali radix, Bu-zhong-yi-qi-tang (TJ-41), Liu-jun-zi-tang 
   (TJ-43), Shi-quan-da-bu-tang (TJ-48), and Ban-xia-xie-xin-tang (TJ-14)) and some 
   acupuncture points (e.g., Zusanli (ST36), Zhongwan (CV12), Neiguan (PC6) and 
   Baihui (GV20)) that are commonly used to treat cancer-related symptoms and/or to 
   reduce the toxicity of chemotherapy, radiotherapy, or targeted-therapy are 
   highlighted and summarized. Through a review of literature, we conclude that TCM 
   can effectively alleviate adverse gastrointestinal reactions (including diarrhea, 
   nausea, and vomiting) to these anti-cancer therapies, decrease the incidence of 
   bone marrow suppression, alleviate cardiotoxicity, and protect against 
   chemotherapy-induced peripheral neuropathy and radiation-induced pneumonitis. 
   Moreover, TCM can alleviate epidermal growth factor receptor-tyrosine kinase 
   inhibitor (EGFR-TKI)-related acneiform eruptions, diarrhea, and other adverse 
   reactions. The hope is that this review can contribute to an understanding of TCM 
   as an adjuvant therapy for cancer and that it can provide useful information for 
   the development of more effective anti-cancer therapies. However, more rigorously 
   designed trials involving cancer treatment must be conducted in the future, 
   including complete quality control and standardized models at the cellular, 
   organic, animal and clinical levels, in order to study TCM in multiple forms and 
   at multiple levels.
C1 Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Ji'nan, China.
   Gynecology, Jinan Municipal Hospital of Traditional Chinese Medicine, Ji'nan, China.
   Gastrointestinal Surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Ji'nan, China.
   Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Ji'nan, China.
   Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Ji'nan, China.
NR 0
TC 0
SN 1881-782
EI 
J9 Biosci Trends
PD AUG 24
PY 2021
VL 15
IS 5
BP 283
EP 298
DI 10.5582/bst.2021.01318 
PG 15
WC Animals; Combined Modality Therapy; Databases, Factual; Drugs, Chinese Herbal; therapeutic use; Humans; Medicine, Chinese Traditional; Neoplasms; complications; Quality of Life
UT PubMed:34421064
PM 34421064
DA 2021-08-24
ER

PT J
AU Ali, A
   Vitulano, LA
AF Ali, Ather
   Vitulano, Lawrence A
TI A brief report: Yale Research Symposium on Complementary and Integrative 
SO The Yale journal of biology and medicine
LA English
DT Journal Article
AB The 2010 Yale Research Symposium on Complementary and Integrative Medicine 
   highlighted original research in related areas by Yale faculty and provided a 
   forum to discuss and debate issues of evidence and plausibility. In this brief 
   report, we describe selected presentations on such diverse foci as nutritional 
   influences on cancer, acupuncture for low back pain, protein intake's effects on 
   bone consumption, Chinese herb-derived adjuvant chemotherapy, and the 
   relationship between anger and cardiac arrhythmia. This symposium demonstrated 
   that rigorous research methods are being used to study unconventional therapies 
   and that an integrative medicine approach requires a solid scientific foundation.
C1 Prevention Research Center, Yale University School of Medicine, New Haven, Connecticut 06418, USA. ather.ali@yale.edu
NR 0
TC 0
SN 1551-405
EI 0044-008
J9 Yale J Biol Med
PD OCT 5
PY 2010
VL 83
IS 3
BP 123
EP 5
DI 
PG -118
WC Acupuncture; Complementary Therapies; methods; Congresses as Topic; Humans; Integrative Medicine; methods; Neoplasms; drug therapy
UT PubMed:20885898
PM 20885898
DA 2010-10-05
ER

PT J
AU Litscher, G
AF Litscher, Gerhard
TI Introduction to the Medicines Special Issue on Acupuncture-Basic Research and 
SO Medicines (Basel, Switzerland)
LA English
DT Editorial
DE acupuncture; depression; low back pain (LBP); moxibustion; myopia; osteoarthritis; post-stroke; pulse diagnosis; sciatica; uterine cancer
AB This Medicines special issue focuses on the further investigation, development, 
   and modernization of acupuncture in basic research settings, as well as in 
   clinical applications. The special issue contains 12 articles reporting latest 
   evidence-based results of acupuncture research, and exploring acupuncture in 
   general. Altogether 44 authors from all over the world contributed to this 
   special issue.
C1 Research Unit for Complementary and Integrative Laser Medicine, Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine, and TCMResearch Center Graz, Medical University of Graz, Auenbruggerplatz 39, EG19, 8036Graz, Austria. gerhard.litscher@medunigraz.at.
NR 0
TC 0
SN 2305-632
EI 2305-632
J9 Medicines (Basel)
PD SEP 6
PY 2018
VL 5
IS 3
BP 
EP 
DI 10.3390/medicines5030099 
PG 0
UT PubMed:30181449
PM 30181449
DA 2018-09-06
ER

PT J
AU Mao, JJ
   Pillai, GG
   Andrade, CJ
   Ligibel, JA
   Basu, P
   Cohen, L
   Khan, IA
   Mustian, KM
   Puthiyedath, R
   Dhiman, KS
   Lao, L
   Ghelman, R
   Cáceres, Guido P
   Lopez, G
   Gallego-Perez, DF
   Salicrup, LA
AF Mao, Jun J
   Pillai, Geetha Gopalakrishna
   Andrade, Carlos Jose
   Ligibel, Jennifer A
   Basu, Partha
   Cohen, Lorenzo
   Khan, Ikhlas A
   Mustian, Karen M
   Puthiyedath, Rammanohar
   Dhiman, Kartar Singh
   Lao, Lixing
   Ghelman, Ricardo
   Cáceres Guido, Paulo
   Lopez, Gabriel
   Gallego-Perez, Daniel F
   Salicrup, Luis Alejandro
TI Integrative oncology: Addressing the global challenges of cancer prevention and 
SO CA: a cancer journal for clinicians
LA English
DT Review
DE alternative; and integrative medicine; cancer prevention; complementary; global health; health policy; survivorship
AB The increase in cancer incidence and mortality is challenging current cancer care 
   delivery globally, disproportionally affecting low- and middle-income countries 
   (LMICs) when it comes to receiving evidence-based cancer prevention, treatment, 
   and palliative and survivorship care. Patients in LMICs often rely on 
   traditional, complementary, and integrative medicine (TCIM) that is more 
   familiar, less costly, and widely available. However, spheres of influence and 
   tensions between conventional medicine and TCIM can further disrupt efforts in 
   evidence-based cancer care. Integrative oncology provides a framework to research 
   and integrate safe, effective TCIM alongside conventional cancer treatment and 
   can help bridge health care gaps in delivering evidence-informed, 
   patient-centered care. This growing field uses lifestyle modifications, mind and 
   body therapies (eg, acupuncture, massage, meditation, and yoga), and natural 
   products to improve symptom management and quality of life among patients with 
   cancer. On the basis of this review of the global challenges of cancer control 
   and the current status of integrative oncology, the authors recommend: 1) 
   educating and integrating TCIM providers into the cancer control workforce to 
   promote risk reduction and culturally salient healthy life styles; 2) developing 
   and testing TCIM interventions to address cancer symptoms or treatment-related 
   adverse effects (eg, pain, insomnia, fatigue); and 3) disseminating and 
   implementing evidence-based TCIM interventions as part of comprehensive 
   palliative and survivorship care so patients from all cultures can live with or 
   beyond cancer with respect, dignity, and vitality. With conventional medicine and 
   TCIM united under a cohesive framework, integrative oncology may provide citizens 
   of the world with access to safe, effective, evidence-informed, and culturally 
   sensitive cancer care.
C1 Bendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, New York, New York.
   Traditional, Complementary and Integrative Medicine Unit, Service Delivery and Safety Department, World Health Organization, Geneva, Switzerland.
   Brazilian National Cancer Institute, Rio de Janeiro, Brazil.
   Leonard P. Zakim Center for Integrative Therapies and Healthy Living, Dana-Farber Cancer Institute, Boston, Massachusetts.
   Harvard Medical School, Boston, Massachusetts.
   International Agency for Research on Cancer, World Health Organization, Lyon, France.
   Integrative Medicine Program, Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston,Texas.
   National Center for Natural Products Research, University of Mississippi, Jackson, Mississippi.
   Wilmot Cancer Institute, Department of Surgery, University of Rochester Medical Center, Rochester, New York.
   Amrita Vishwa Vidyapeetham University, Amritapuri, Kerala, India.
   Central Council for Research in Ayurvedic Sciences, New Delhi, India.
   Virginia University of Integrative Medicine, Fairfax, Virginia.
   Brazilian Academic Consortium for Integrative Health, University of São Paulo, São Paulo, Brazil.
   Pharmacokinetics and Research in Clinical Pharmacology and Integrative Medicine Group, Garrahan Pediatric Hospital, Buenos Aires, Argentina.
   Traditional, Complementary, and Integrative Medicine Network of the Americas, São 
   Integrative Medicine Program, Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston,Texas.
   Traditional, Complementary, and Integrative Medicine Network of the Americas, São Paulo, Brazil.
   Boston University School of Public Health, Boston, Massachusetts.
   Center for Global Health and Office of Cancer Complementary and Alternative Medicine, Division of Cancer Treatment and Diagnosis, National Cancer Institute,National Institutes of Health, Rockville, Maryland.
NR 0
TC 0
SN 1542-486
EI 
J9 CA Cancer J Clin
PD NOV 10
PY 2021
VL 72
IS 2
BP 144
EP 164
DI 10.3322/caac.21706 
PG 20
WC Complementary Therapies; Delivery of Health Care; Humans; Integrative Medicine; Integrative Oncology; Neoplasms; prevention & control; Quality of Life
UT PubMed:34751943
PM 34751943
DA 2021-11-10
ER

PT J
AU Li, X
   Baser, RE
   Bryl, K
   Amann, L
   Chimonas, S
   Mao, JJ
AF Li, Xiaotong
   Baser, Raymond E
   Bryl, Karolina
   Amann, Lindsay
   Chimonas, Susan
   Mao, Jun J
TI How does pretreatment expectancy influence pain outcomes with electroacupuncture 
SO Integrative medicine research
LA English
DT Journal Article
DE Battlefield acupuncture; Electroacupuncture; Expectancy; Nonspecific effect; Pain
AB BACKGROUND: Outcome expectancy is an important component of non-specific effect 
   that may play an important role in pain research and clinical care. We sought to 
   evaluate whether pretreatment expectancy predicts pain reduction in cancer 
   survivors receiving electroacupuncture (EA) or battlefield acupuncture (BFA). 
   METHODS: We analyzed data from a randomized clinical trial that compared EA and 
   BFA versus wait list control (WLC) for chronic musculoskeletal pain in cancer 
   survivors. Expectancy was measured by the Acupuncture Expectancy Scale (AES) at 
   baseline. Pain severity was assessed using the Brief Pain Inventory (BPI) at 
   baseline and week 12. For each treatment arm, multivariable regression models 
   were used to evaluate the association between pretreatment expectancy and week 12 
   pain severity, controlling for baseline pain severity, age, sex, race, and 
   education. RESULTS: Among 360 participants enrolled, the mean age was 62.1 years 
   (SD 12.7), with 251 (69.7 %) women and 88 (24.4 %) non-white survivors. 
   Pretreatment expectancy was similar for all groups at baseline (EA: 13.9 ± 3.6; 
   BFA: 13.2 ± 3.7, WLC:12.8 ± 3.3, p = 0.14). Greater pretreatment expectancy was 
   not significantly associated with greater pain reduction in any group, after 
   adjusting for co-variates (EA: Coef. = -0.05, 95 % CI = -0.14 - 0.04, p = 0.28; 
   BFA: Coef. = -0.07, 95 % CI = -0.16 - 0.02, p = 0.15; WLC: Coef. = -0.09, 95 % CI 
   = -0.25 - 0.06, p = 0.23). CONCLUSIONS: Pretreatment expectancy did not predict 
   pain reduction for either EA or BFA in cancer survivors. Our study contributes to 
   the interpretation of analgesic effects of EA or BFA, beyond the notion of a mere 
   'placebo effect'.
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Center for Health Policy and Outcomes, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer 
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
NR 0
TC 0
SN 2213-423
EI 2213-422
J9 Integr Med Res
PD MAY 9
PY 2024
VL 13
IS 2
BP 101040
EP 101040
DI 10.1016/j.imr.2024.101040 
PG 0
UT PubMed:38721341
PM 38721341
DA 2024-05-09
ER

PT J
AU Sima, L
   Fan, B
   Yan, L
   Shui, Y
AF Sima, Lei
   Fan, Bifa
   Yan, Longtao
   Shui, Yuan
TI Effects of Electroacupuncture Treatment on Bone Cancer Pain Model with Morphine 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB Objective. To explore the efficacy of electroacupuncture treatment in cancer 
   induced bone pain (CIBP) rat model with morphine tolerance and explore changes of 
   calcitonin-gene related peptide (CGRP) expression in dorsal root ganglion (DRG). 
   Methods. Forty SD rats were divided into five groups: sham, CIBP (B), CIBP + 
   morphine (BM), CIBP + electroacupuncture (BE), and CIBP + morphine + 
   electroacupuncture (BME). B, BM, BE, and BME groups were prepared CIBP model. The 
   latter three groups then accepted morphine, electroacupuncture, and morphine 
   combined electroacupuncture, separately, nine days consecutively (M1 to M9). 
   Mechanical withdraw threshold (MWT) was evaluated. Results. BE group only had 
   differences in M1, M2, and M3 compared to B group (P < 0.01). From M5, BM group 
   showed significantly decreased MWT. Electroacupuncture could obtain analgesic 
   effects only at early stage (M1 to M5). From M5 to M9, BME had the differences 
   with BM group (P < 0.01). IOD value of CGRP in BM and BME was substantially less 
   than in B group. CGRP in BME was significantly lower than that in BM group (P < 
   0.01). Conclusion. When used in combination with electroacupuncture, morphine 
   could result in improving analgesic effects and reducing tolerance. CGRP may be 
   associated with pain behaviors.
C1 National Pain Management and Research Center, China-Japan Friendship Hospital, Beijing, China.
   National Pain Management and Research Center, China-Japan Friendship Hospital, Beijing, China.
   National Pain Management and Research Center, China-Japan Friendship Hospital, Beijing, China.
   National Pain Management and Research Center, China-Japan Friendship Hospital, Beijing, China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD SEP 28
PY 2016
VL 2016
IS 
BP 8028474
EP 8028474
DI 10.1155/2016/8028474 
PG 0
UT PubMed:27672401
PM 27672401
DA 2016-09-28
ER

PT J
AU Frenkel, M
   David, A
   Sapire, K
   Hausner, D
AF Frenkel, Moshe
   David, Adi
   Sapire, Kenneth
   Hausner, David
TI Complementary and Integrative Medicine in Pancreatic Cancer.
SO Current oncology reports
LA English
DT Review
DE Acupuncture; Complementary medicine; Curcumin; Dietary supplements; Homeopathy; Integrative medicine; Mind–body medicine; Nutrition; Nutritional supplements; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Physical activity; Reflexology; Touch therapies
AB PURPOSE OF REVIEW: Pancreatic cancer has high mortality and morbidity rates, 
   associated with the issues of typically late diagnosis and the limited 
   effectiveness of current treatments. Patients tend to experience multiple 
   symptoms that can include anxiety, fear, depression, fatigue, weakness, 
   peripheral neuropathy, and abdominal pain, which reduce quality of life (QoL) and 
   may compromise the treatment continuum. Many of those symptoms are amenable to 
   complementary and integrative medicine (CIM) therapies as a part of supportive 
   and palliative care. This article reviews research findings on the beneficial 
   effect of use of CIM modalities in regard to pancreatic cancer, with emphasis on 
   pancreatic ductal adenocarcinoma (PDAC). RECENT FINDINGS: Given the often-poor 
   prognosis of the disease, patients with PDAC often seek integrative therapies to 
   help manage the disease itself, to provide support through cancer treatment and 
   its symptoms, and to provide emotional stress relief. Data is accumulating in the 
   past few years on the potential benefits of CIM to the management of pancreatic 
   cancer symptoms and treatment side effects, in order to augment supportive care. 
   This data reveal that nutrition counselling; digestive enzyme therapy; microbiome 
   support; dietary supplements; lifestyle interventions (physical activity and 
   circadian health/sleep hygiene) appear to improve QoL of these patients through 
   reduced symptom burden and meeting psychological needs, such as distress and 
   fatigue. Acupuncture, mindfulness, yoga, reflexology, massage, and homeopathy may 
   also contribute to symptom reduction, both physical and psychological, in all 
   stages of the disease. There is supporting evidence that some CIM modalities may 
   alleviate side effects and symptoms related to pancreatic cancer and its 
   treatment, suggesting that practitioners might consider integrating these 
   modalities in certain situations encountered in the treatment of pancreatic 
   cancer. Further investigation is needed to define the optimal integration of CIM 
   into the treatment and supportive care of patients affected by pancreatic cancer.
C1 Complementary and Integrative Medicine Service, Oncology Division, Rambam Health Care Campus, Haifa, Israel. frenkelm@netvision.net.il.
   Tal Center for Integrative Medicine, Institute of Oncology, Chaim Sheba Medical Center, Ramat-Gan, Israel.
   Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
   Tal Center for Integrative Medicine, Institute of Oncology, Chaim Sheba Medical Center, Ramat-Gan, Israel.
   Palliative Care Service, Chaim Sheba Medical Center, Ramat Gan, Israel.
NR 0
TC 0
SN 1534-626
EI 
J9 Curr Oncol Rep
PD FEB 4
PY 2023
VL 25
IS 3
BP 231
EP 242
DI 10.1007/s11912-023-01370-z 
PG 11
WC Humans; Quality of Life; psychology; Integrative Medicine; Complementary Therapies; Pancreatic Neoplasms; Fatigue; therapy
UT PubMed:36735141
PM 36735141
DA 2023-02-04
ER

PT J
AU Andreazzoli, F
   Levy, Yurkovski I
   Ben-Arye, E
   Bonucci, M
AF Andreazzoli, Francesca
   Levy Yurkovski, Ilana
   Ben-Arye, Eran
   Bonucci, Massimo
TI Conceptualizing an Integrative Multiple Myeloma Care: The Role of Nutrition, 
SO Nutrients
LA English
DT Review
DE Multiple Myeloma; acupuncture; integrative medicine; nutrition; supplementation; vitamin D
AB Multiple Myeloma (MM) is the second most prevalent hematologic malignancy, and 
   its incidence has been increasing enormously in recent years. The prognosis of MM 
   has changed radically with the introduction of new drugs that have improved life 
   expectancy; recurrences are a common occurrence during the course of the disease 
   and are characterized by an increase in refractory to treatment. Moreover, MM 
   patients are challenged by quality of life-related concerns while limited 
   conventional therapy may be offered. This includes bone pain and dialysis due to 
   the complications of acute renal failure. We, therefore, believe that it is very 
   important to add new treatment modalities, including supplements, nutritional 
   modifications, acupuncture, and mind-body therapies, with the goal of improving 
   treatment tolerance, effectiveness, and patients' quality of life. Moreover, many 
   patients use some of these supplements on their own, in the hope of reducing the 
   side effects, so it is even more important to know their action and potential. 
   The purpose of this review is to illustrate all these strategies potentially 
   available to enrich our approach to this, to date, incurable disease.
C1 Department of Hematology, Versilia's Hospital, Viale Aurelia, 335, 55049 Camaiore, Italy.
   Hematology Unit, Bnai Zion Medical Center, Haifa 3339419, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 
   Complementary and Integrative Medicine Service, Bnai Zion Medical Center, Haifa 3339419, Israel.
   Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3109601, Israel.
   Integrative Oncology Program, The Oncology Service, Lin Carmel, and Zebulun 
   Artoi Foundation, Via Ludovico Micara, 73, 00165 Rome, Italy.
NR 0
TC 0
SN 2072-664
EI 
J9 Nutrients
PD JAN 23
PY 2024
VL 16
IS 2
BP 
EP 
DI 10.3390/nu16020237 
PG 0
WC Humans; Multiple Myeloma; complications; Quality of Life; Renal Dialysis; Nutritional Status; Hematologic Neoplasms
UT PubMed:38257130
PM 38257130
DA 2024-01-23
ER

PT J
AU Lown, EA
   Banerjee, A
   Vittinghoff, E
   Dvorak, CC
   Hartogensis, W
   Melton, A
   Mangurian, C
   Hu, H
   Shear, D
   Adcock, R
   Morgan, M
   Golden, C
   Hecht, FM
AF Lown, E Anne
   Banerjee, Anu
   Vittinghoff, Eric
   Dvorak, Christopher C
   Hartogensis, Wendy
   Melton, Alexis
   Mangurian, Christina
   Hu, Hiroe
   Shear, Deborah
   Adcock, Robyn
   Morgan, Michael
   Golden, Carla
   Hecht, Frederick M
TI Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and 
SO Global advances in health and medicine
LA English
DT Journal Article
DE acupressure; acupuncture; childhood cancer; nausea; pain; symptom management; vomiting
AB BACKGROUND: We describe the study design and protocol of a pragmatic randomized 
   controlled trial (RCT) Acupressure for Children in Treatment for a Childhood 
   Cancer (ACT-CC). OBJECTIVE: To describe the feasibility and effectiveness of an 
   acupressure intervention to decrease treatment-related symptoms in children in 
   treatment for cancer or recipients of a chemotherapy-based hematopoietic stem 
   cell transplant (HSCT). DESIGN: Two-armed RCTs with enrollment of 5 to 30 study 
   days. SETTING: Two pediatric teaching hospitals. PATIENTS: Eighty-five children 
   receiving cancer treatment or a chemotherapy-based HSCT each with 1 parent or 
   caregiver. INTERVENTION: Patients are randomized 1:1 to receive either usual care 
   plus daily professional acupressure and caregiver delivered acupressure versus 
   usual care alone for symptom management. Participants receive up to 20 
   professional treatments. MAIN OUTCOME: A composite nausea/vomiting measure for 
   the child. SECONDARY OUTCOMES: Child's nausea, vomiting, pain, fatigue, 
   depression, anxiety, and positive affect. PARENT OUTCOMES: Depression, anxiety, 
   posttraumatic stress symptoms, caregiver self-efficacy, and positive affect. 
   Feasibility of delivering the semistandardized intervention will be described. 
   Linear mixed models will be used to compare outcomes between arms in children and 
   parents, allowing for variability in diagnosis, treatment, and age. DISCUSSION: 
   Trial results could help childhood cancer and HSCT treatment centers decide about 
   the regular inclusion of trained acupressure providers to support symptom 
   management.
C1 Social and Behavioral Sciences, School of Nursing, University of California, San Francisco, California.
   Department of Neurological Surgery, University of California, San Francisco, California.
   Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California.
   Division of Pediatric Allergy, Immunology, & Blood and Marrow Transplantation, University of California, San Francisco, California.
   Osher Center for Integrative Medicine, University of California, San Francisco, California.
   Division of Pediatric Allergy, Immunology, & Blood and Marrow Transplantation, University of California, San Francisco, California.
   Department of Psychiatry, School of Medicine, University of California, San Francisco, California.
   Social and Behavioral Sciences, School of Nursing, University of California, San Francisco, California.
   Social and Behavioral Sciences, School of Nursing, University of California, San Francisco, California.
   Compass Care/Integrative Pediatric Pain and Palliative Care (IP3), UCSF Benioff Children's Hospital, San Francisco, California.
   Social and Behavioral Sciences, School of Nursing, University of California, San Francisco, California.
   Department of Pediatric Hematology-Oncology, UCSF Benioff Children's Hospital, Oakland, California.
   Osher Center for Integrative Medicine, University of California, San Francisco, California.
NR 0
TC 0
SN 2164-956
EI 2164-957
J9 Glob Adv Health Med
PD AUG 28
PY 2019
VL 8
IS 
BP 2164956119870444
EP 2164956119870444
DI 10.1177/2164956119870444 
PG 1
UT PubMed:31453017
PM 31453017
DA 2019-08-28
ER

PT J
AU Li, DH
   Su, YF
   Fan, HF
   Guo, N
   Sun, CX
AF Li, De-Hui
   Su, Yi-Fan
   Fan, Huan-Fang
   Guo, Na
   Sun, Chun-Xia
TI Acupuncture Combined with Three-Step Analgesic Drug Therapy for Treatment of 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Review
AB OBJECTIVE: The purpose of this study was to systematically evaluate the efficacy 
   and safety of acupuncture combined with the WHO three-step analgesic drug ladder 
   for cancer pain. METHODS: The Cochrane Library, PubMed, and CNKI Database of 
   Systematic Reviews were searched. Using the Cochrane Register for Randomized 
   Controlled Trials, the quality of the included literature was evaluated, and the 
   meta-analysis was carried out with RevMan 5.3 software. RESULTS: Compared with 
   three-step analgesia alone, acupuncture combined with three-step analgesia for 
   cancer pain increased pain relief response rates (RR = 1.12, 95% CI: 1.08∼1.17, P 
   < 0.00001), reduced NRS score (SMD = -1.10, 95% CI: -1.86∼-0.35, P=0.004), 
   reduced the rate of side effects (RR = 0.45, 95% CI: 0.38∼0.53, P < 0.00001), 
   including nausea (P < 0.00001), vomiting (P=0.008), constipation (P < 0.00001), 
   and dizziness (P=0.010), reduced the burst pain rate (SMD = -1.38; 95% CI: 
   -2.44∼-0.32, P=0.01), shortened analgesia effect onset time (P=0.004), and 
   extended the duration of response (P < 0.0001). CONCLUSION: For the treatment of 
   cancer pain, acupuncture combined with three-step analgesic drugs is better than 
   using only three-step analgesic drugs.
C1 Hebei Province Hospital of Chinese Medicine, The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China.
   Hebei Province Hospital of Chinese Medicine, The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China.
   Graduate School of Hebei University of Chinese Medicine, Shijiazhuang 050091, 
   Hebei Province Hospital of Chinese Medicine, The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China.
   Hebei Province Hospital of Chinese Medicine, The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China.
   Hebei Province Hospital of Chinese Medicine, The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD AUG 6
PY 2021
VL 2021
IS 
BP 5558590
EP 5558590
DI 10.1155/2021/5558590 
PG 0
UT PubMed:34349826
PM 34349826
DA 2021-08-06
ER

PT J
AU Lin, YP
   Li, YJ
   Chen, BL
   Guo, YH
AF Lin, Yong-Peng
   Li, Yong-Jin
   Chen, Bo-Lai
   Guo, Yu-Hai
TI Lumbar laminotomy and replantation for the treatment of adult spinal epidermoid 
SO Medicine
LA English
DT Journal Article
AB RATIONALE: Adult spinal epidermoid cyst (SEC) is a rare tumor. Lumbar laminectomy 
   and tumor removal was a routine surgical procedure for adult spinal epidermoid 
   cyst according to the literature, but postoperative lumbar instability and 
   intractable low back pain may occur. In this study, we presented a brief report 
   of an adult lumbar epidermoid cyst and introduced another surgical approach. 
   PATIENT CONCERNS: This 28-year-old woman has been complaining of the severe right 
   buttock pain and right thigh radiating pain for half a year. She had been 
   diagnosed as sacroiliitis, spinal arthritis, and lumbar disc herniation at 3 
   different hospitals before coming to our hospital. And she received a variety of 
   conservative treatments, including non-steroidal anti-inflammatory drugs, 
   aspirin, acetaminophen, glucocorticoids, acupuncture, physical therapy, and so 
   on. However, her pain did not diminish at all. Finally, we find a space-occupying 
   lesion in her lumbar magnetic resonance images (MRI). The lesion was slightly 
   low, equal, and uneven equal-low signals on T1WI. T2WI showed slightly higher, 
   equal, and uneven equal-high signals. And a thin-rim enhancement was observed on 
   Gd-DTPA-enhanced MRI. DIAGNOSES: Adult spinal epidermoid cyst. INTERVENTIONS: The 
   patient underwent a surgery of lumbar laminectomy, tumor excision, and spinous 
   process-vertebral plate in situ replantation. OUTCOMES: Postoperative pathology 
   prompted that the tumor was cystoid. The patient's symptoms were completely 
   removed 1 week after surgery. Three-month postoperative MRI confirmed that the 
   spinal epidermoid cyst had been completely removed and three-dimensional CT 
   prompted lumbar lamina in situ. Bony fusion occurred at 6 months after the 
   surgery. LESSONS: Lumbar laminotomy and replantation provides an ideal option to 
   treat adult spinal epidermoid cyst because it can completely remove the cyst and 
   simultaneously reduce the risk of iatrogenic lumbar instability.
C1 Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD MAR 6
PY 2018
VL 97
IS 1
BP e9334
EP e9334
DI 10.1097/MD.0000000000009334 
PG 1
WC Adult; Epidermal Cyst; diagnostic imaging; Female; Humans; Laminectomy; methods; Lumbar Vertebrae; diagnostic imaging; Replantation; Spinal Diseases; diagnostic imaging
UT PubMed:29505514
PM 29505514
DA 2018-03-06
ER

PT J
AU Loy, MH
   Prisco, L
   Parikh, C
AF Loy, Michelle H
   Prisco, Lauren
   Parikh, Chiti
TI Implementation of Virtual Integrative Oncology Shared Medical Appointment Series 
SO Integrative cancer therapies
LA English
DT Journal Article
DE acupuncture; botanicals; complementary integrative medicine; culinary medicine; group medical visits (GMV); herbs; integrative oncology (IO); mind-body; nutrition; qi gong; shared medical appointment (SMA); supplements; telehealth; virtual integrative oncology shared medical appointment series (VIOSMAS); vitamins; yoga
AB BACKGROUND: Integrative oncology [IO] is sought-after by patients, endorsed by 
   clinical guidelines, and valued within National Cancer Institute Centers. Shared 
   Medical Appointments [SMA] leverage health education and social connection to 
   deliver enhanced patient experience, population health, cost-reduction, and 
   clinician well-being. Integrative Oncology Shared Medical Appointments increase 
   access to integrative medicine but delivering these services via telehealth have 
   not been evaluated. OBJECTIVE: We created, and pilot tested a Virtual Integrative 
   Oncology Shared Medical Appointment Series (VIOSMAS) to assess its feasibility, 
   acceptability, and efficacy at an urban academic teaching hospital. METHODS: The 
   7-session hour-long Living Well with and after Cancer series included didactics, 
   multi-disciplinary experiential sessions, and group discussion. Topics included 
   (1) Introduction, (2) Herbs/Botanicals/Fungi, (3) Mindful Movement, (4) 
   Acupuncture, (5) Narratives and Nature, (6) Diet and Culinary Medicine, and (7) 
   Vitamins/Supplements. Virtual visits via telehealth were offered to enhance 
   patient participation during the pandemic. Outcome measures included recruitment, 
   retention, pre/post-series patient survey and qualitative clinician feedback. 
   RESULTS: Between 9/2021 and 4/2023, 72 unique patients were recruited to 5 
   cohorts and had a total of 332 VIOSMAS visits. A total of 50 patients (69%) 
   attended 4 or more of the 7-session series; 60 (83% were women); patients ranged 
   in age from 28 to 93 years (median 66); 36 (50%) lived outside the city center; 
   the most common cancer diagnoses were breast, lymphoma, and lung cancer. Patients 
   were from diverse demographics. Pre-program, patients reported desiring 
   assistance in addressing diverse symptoms including fatigue, insomnia, pain, 
   gastrointestinal (GI) symptoms, anxiety, and depression. Post-series, patients 
   reported that the VIOSMAS addressed their goals and symptoms; they also reported 
   incorporating recommended lifestyle changes in diet, exercise, sleep, and stress 
   management; they were satisfied with the number of sessions and telehealth 
   format. The participating clinicians reported high levels of satisfaction with 
   VIOSMAS. Revenue to the institution from VIOSMAS exceeded the revenue potential 
   of equivalent time spent for individual visits while supporting extended 
   physician-patient contact. CONCLUSION: VIOSMAS is feasible for patients and 
   clinicians, addresses patients' symptoms and questions about lifestyle and 
   complementary therapies, and generates more revenue than individual visits. 
   Larger implementation trials with appropriate comparison groups are recommended.
C1 Cornell University, New York, NY, USA.
   Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA.
   Cornell University, New York, NY, USA.
   Cornell University, New York, NY, USA.
   Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD JAN 20
PY 2024
VL 23
IS 
BP 15347354231223969
EP 15347354231223969
DI 10.1177/15347354231223969 
PG 1
WC Humans; Female; Adult; Middle Aged; Aged; Aged, 80 and over; Male; Integrative Oncology; Shared Medical Appointments; Complementary Therapies; Breast; Lung Neoplasms
UT PubMed:38243739
PM 38243739
DA 2024-01-20
ER

PT J
AU Saraswati, W
   Rosyiadi, MR
   Imandiri, A
AF Saraswati, Wita
   Rosyiadi, Mochammad Rizalul
   Imandiri, Ario
TI Electroacupuncture Versus Analgesics for Patients with Stage IIIB Cervical Cancer 
SO Medical acupuncture
LA English
DT Journal Article
DE cancer pain; electroacupuncture; pain scale; paracetamol–codeine; quality of life; β-endorphin
AB Background: The prevalence of pain at advanced cervical cancer stages is 
   increasing. Existing World Health Organization recommendations for management 
   comprises a 3-step ladder of analgesic therapy but this still cannot address this 
   pain optimally. An alternative therapy used to reduce pain, acupuncture, is 
   almost without side-effects, is safe, and is easy to implement. This study 
   compared electroacupuncture (EA) versus paracetamol 500 mg +10-mg codeine therapy 
   for patients with stage-IIIB cervical cancer post cisplatin chemotherapy. 
   Materials and Methods: Participants were divided into 2 groups (treatment and 
   control groups). A quasiexperimental study was conducted using a nonequivalent 
   control group pretest-post-test design. Participants in the treatment group were 
   given EA for 30 minutes 10 times over 3 weeks, while participants in the control 
   group were given paracetamol 3 × 500 mg and codeine 3 × 10 mg orally every day 
   for 3 weeks. Statistical analysis used paired t-tests, a Wilcoxon test, an 
   independent t-test, or a Mann-Whitney-U test with P < 0.05. Results: Pretest and 
   post-test pain-scale levels were 5.39 ± 0.62 and 4.57 ± 0.88, respectively 
   (P < 0.001). Average endorphin-β levels at pretest and post-test were 
   571.80 ± 281.13 and 491.14 ± 272.14, respectively (P = 0.818). Median values of 
   quality of life at pretest and post-test were 681.75 (range: 503.80-915.20) and 
   635.25 (range: 538.20-781.20; P = 0.383), respectively. Conclusions: Pain-control 
   therapy using drugs or EA produces similar results. However, EA, subjectively, 
   produces improved pain-scale results better than pharmaceuticals.
C1 Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
   Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
   Department of Traditional Healer, Faculty of Vocations, Universitas Airlangga, Surabaya, Indonesia.
   The Traditional Poly Herbal Medicine, Universitas Airlangga Teaching Hospital, 
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD OCT 27
PY 2020
VL 32
IS 5
BP 293
EP 299
DI 10.1089/acu.2020.1425 
PG 6
UT PubMed:33101574
PM 33101574
DA 2020-10-27
ER

PT J
AU Christensen, Holz S
AF Christensen Holz, Sara
TI Aromatase Inhibitor Musculoskeletal Syndrome and Bone Loss: a Review of the 
SO Current oncology reports
LA English
DT Review
DE Aromatase inhibitor; Cancer rehabilitation; Cancer treatment side effects; Musculoskeletal complications
AB PURPOSE OF REVIEW: The study aims to review the literature regarding 
   musculoskeletal complications of aromatase inhibitors and treatment options for 
   these complications. RECENT FINDINGS: Aromatase inhibitors are common medications 
   to treat hormone receptor-positive breast cancer in postmenopausal women and have 
   been shown to improve survival and prevent disease recurrence. However, 20-60% 
   patients stop treatment prematurely due to side effects. Side effects include 
   joint stiffness and pain, tendonitis, tendon tears, muscle pain, and carpal 
   tunnel syndrome known as aromatase inhibitor musculoskeletal syndrome (AIMSS) as 
   well as bone loss. Proposed mechanisms of AIMSS include decreased estrogen 
   levels, inflammation, and genetic factors. Switching aromatase inhibitors, 
   exercise, non-steroidal anti-inflammatory medications, duloxetine, acupuncture, 
   prednisone, and bisphosphonates are some treatment options for this syndrome and 
   will be discussed in more detail in this review. Aromatase inhibitors are 
   important in the treatment of hormone receptor-positive breast cancer in 
   postmenopausal women. As we study the incidence of side effects of these 
   medications including bone loss and AIMSS and determine the mechanisms of these 
   symptoms and possible treatment options, we will decrease the incidence of 
   patients discontinuing treatment prematurely and improve symptoms, quality of 
   life, and survival in this patient population.
C1 School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. christensenholz@rehab.wisc.edu.
NR 0
TC 0
SN 1534-626
EI 
J9 Curr Oncol Rep
PD APR 14
PY 2023
VL 25
IS 7
BP 825
EP 831
DI 10.1007/s11912-023-01413-5 
PG 6
WC Humans; Female; Aromatase Inhibitors; adverse effects; Quality of Life; Neoplasm Recurrence, Local; drug therapy; Breast Neoplasms; drug therapy; Diphosphonates; therapeutic use
UT PubMed:37052869
PM 37052869
DA 2023-04-14
ER

PT J
AU Bari, S
   Chineke, I
   Darwin, A
   Umar, A
   Jim, H
   Muzaffar, J
   Singh, S
   Kucuk, O
AF Bari, Shahla
   Chineke, Iloabueke
   Darwin, Alicia
   Umar, Anam
   Jim, Heather
   Muzaffar, Jameel
   Singh, Shailesh
   Kucuk, Omer
TI Awareness, Use and Outlook of Complementary and Alternative Medicine (CAM) 
SO Integrative cancer therapies
LA English
DT Journal Article
DE CAM; alternative medicine; complementary medicine; health disparity; integrative medicine
AB Integrative oncology aims to coordinate the delivery of conventional medicine and 
   evidence-supported complementary and alternative medicine (CAM) to patients 
   receiving cancer care. This field developed out of an increased interest in CAM 
   usage among cancer patients. However, CAM use among medically underserved cancer 
   patients remains to be well characterized. We evaluated CAM awareness as well as 
   prevalence and characteristics of CAM use in 170 consecutive, medically 
   underserved cancer patients presenting to a large, academic, inner-city cancer 
   clinic, using a survey tool. Fifty-three participants declined participation and 
   17 survey results were incomplete. Therefore, 100 survey results were included in 
   the final analysis. There were 65 males and 35 females in the survey with a mean 
   age of 64.2 years. About 98% of the respondents were African American while 2% 
   identified themselves as Hispanic. About 45% of patients had metastatic cancer, 
   24% had early-stage disease while 31% of patients were not aware of the stage of 
   their cancer. About 55% patients had elementary school or lower level of 
   education while only 16% had a college degree or higher. About 92% of respondents 
   were unemployed. Some knowledge of CAM was reported by 22% of patients, while CAM 
   use was reported in only 16% of patients. Female sex and college degree were 
   significantly associated with CAM use. The most commonly used CAM modality was 
   meditation (56%), followed by herbal remedies (31%), yoga (31%), and acupuncture 
   (12%). Among CAM users, a majority used multiple CAM therapies. All users 
   reported benefit from CAM use. Emotional wellbeing was the most common benefit 
   followed by improvement in treatment related adverse effects, chemotherapy 
   related symptoms, pain, and sleep. Even though the majority of our surveyed 
   patients never used CAM, 90% of non-users were interested in gaining more 
   information about the various CAM options and exploring its use and potential 
   benefits. The majority (70%) wanted their primary oncologist to provide 
   information about CAM options and discuss its safety and potential complementary 
   benefit in management of their cancer and associated symptoms.
C1 Moffitt Cancer Center, Tampa, FL, USA.
   Morehouse School of Medicine, Atlanta, GA, USA.
   Morehouse School of Medicine, Atlanta, GA, USA.
   University of Arizona Cancer Center, Tucson, AZ, USA
   University of South Florida, Tampa, FL, USA
   Morehouse School of Medicine, Atlanta, GA, USA.
   Moffitt Cancer Center, Tampa, FL, USA.
   Moffitt Cancer Center, Tampa, FL, USA.
   Morehouse School of Medicine, Atlanta, GA, USA.
   Emory University, Atlanta, GA, USA
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD DEC 21
PY 2021
VL 20
IS 
BP 15347354211051622
EP 15347354211051622
DI 10.1177/15347354211051622 
PG 1
WC Complementary Therapies; methods; Female; Humans; Male; Medically Underserved Area; Medically Uninsured; Middle Aged; Neoplasms; therapy; Surveys and Questionnaires; Yoga
UT PubMed:34923869
PM 34923869
DA 2021-12-21
ER

PT J
AU Kocot-Kępska, M
   Zajączkowska, R
   Zhao, J
   Wordliczek, J
   Tomasik, PJ
   Przeklasa-Muszyńska, A
AF Kocot-Kępska, Magdalena
   Zajączkowska, Renata
   Zhao, Jing
   Wordliczek, Jerzy
   Tomasik, Przemysław J
   Przeklasa-Muszyńska, Anna
TI The role of complementary and alternative methods in the treatment of pain in 
SO Contemporary oncology (Poznan, Poland)
LA English
DT Review
DE acupuncture; cancer pain; complementary and alternative methods; pain management; physical activity
AB INTRODUCTION: Pain related to cancer, despite the numerous treatment options 
   available, is still a challenge in contemporary pain medicine. The unsatisfactory 
   treatment of cancer pain is one of the main reasons why patients seek 
   complementary and alternative methods (CAM) and a more integrative/holistic 
   approach to pain management. The popularity of CAM forces healthcare 
   professionals to provide patients with current and evidence-based information on 
   the effectiveness and safety of CAM. The aim of the paper is to present current 
   evidence and limitations regarding CAM commonly used in the pain management of 
   cancer patients. MATERIAL AND METHODS: The paper comprehensively reviews the 
   current and most relevant literature considering the integrative approach to 
   management of pain due to cancer disease and/or cancer treatment. RESULTS: The 
   available data from clinical trials, meta-analyses, and systematic reviews 
   supports the effectiveness of acupuncture, massage, physical exercises, music 
   therapy, and mind-body therapies as adjunct therapies for alleviating pain in 
   cancer patients, although the supporting evidence is weak or moderate. 
   CONCLUSIONS: Based on the available knowledge, physicians should be capable of 
   advising the cancer patient as to which CAM methods can be used safely, which are 
   contraindicated, and what therapeutic effects they may expect, especially when 
   standard pain treatment fails or induces serious side effects. An integrative 
   approach to cancer pain management may improve the quality of pain treatment, 
   patients' quality of life, and satisfaction with pain relief.
C1 Department for Pain Research and Treatment, Jagiellonian University Medical College, Krakow, Poland.
   Department of Interdisciplinary Intensive Care, Jagiellonian University Medical College, Krakow, Poland.
   Institute of Basic Research in Clinical Medicine, TCM Clinic, China Academy of Chinese Medical Sciences, Beijing, China.
   Department of Interdisciplinary Intensive Care, Jagiellonian University Medical College, Krakow, Poland.
   Department of Clinical Biochemistry, Polish-American Children's Hospital, Jagiellonian University Medical College, Krakow, Poland.
   Department for Pain Research and Treatment, Jagiellonian University Medical College, Krakow, Poland.
NR 0
TC 0
SN 1897-430
EI 1428-252
J9 Contemp Oncol (Pozn)
PD OCT 21
PY 2021
VL 25
IS 2
BP 88
EP 94
DI 10.5114/wo.2021.105969 
PG 6
UT PubMed:34667434
PM 34667434
DA 2021-10-21
ER

PT J
AU Han, C
   Liu, Y
   Fan, H
   Li, D
   Guo, N
AF Han, Changhui
   Liu, Yingjuan
   Fan, Huanfang
   Li, Dehui
   Guo, Na
TI Acupuncture Relieves Opioid-Induced Constipation in Clinical Cancer Therapy - A 
SO Clinical epidemiology
LA English
DT Review
DE acupuncture; cancer; meta-analysis; opioid-induced constipation; pain
AB Cancer pain is a common problem in clinical cancer therapy. Opioid analgesia is 
   one of the most effective drugs for pain relief with satisfying performance 
   besides the side effect of opioid-induced constipation (OIC). Acupuncture, as a 
   Chinese traditional non-invasive intervention, has been applied to clinical 
   cancer pain management and functional constipation therapy. However, only a few 
   studies have adopted this treatment for OIC patients. Due to limited numbers of 
   investigated subjects and variability of application methods, including treatment 
   apparatus, acupoints, durations, and sessions, the interpretation of 
   acupuncture's therapy effects from single-site randomized clinical trials (RCT) 
   is limited. Therefore, we conducted a meta-analysis by collecting published data 
   from Pubmed, Embase, Cochrane library, and Web of Science. Five RCTs focusing on 
   the application of acupuncture with or without medication in OIC patients were 
   included. An overall remission rate of 86.8% in the acupuncture-treated group was 
   achieved, higher than the control group (78.9%; RR, 1.10, 95% CI [1.03, 1.18]). 
   The symptom scores, reporting on defecation frequency, defecation straining, 
   abdominal pain, defection time, and stool property, in acupuncture groups were 
   lower than control groups with a standardized mean difference (SMD) of -2.21 
   [-4.15, -0.27]. The quality of life (QOL) for patients in the acupuncture treated 
   group increased compared to the control group with reduced PAC-QOL scores (SMD, 
   -1.02 [-1.78, -0.26]). Referring to the effects from pure acupuncture treatment 
   (SMD, -0.43 [-0.83, -0.03]), the co-intervention of acupuncture and drugs (SMD, 
   -1.77 [-2.51, -1.02]) improved the life quality of patients more remarkably (P < 
   0.05). Overall, our data confirmed the therapeutic effects of acupuncture in the 
   treatment of OIC. The co-intervention of acupuncture with drugs improves the 
   outcomes of OIC patients better than a single strategy. Combined therapy with 
   both medicine and acupuncture has insightful potential for future clinical cancer 
   patient management on constipation problems.
C1 Affiliated Hospital of Hebei University of Traditional Chinese Medicine, Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, People'sRepublic of China.
   Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK.
   Affiliated Hospital of Hebei University of Traditional Chinese Medicine, Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, People'sRepublic of China.
   Affiliated Hospital of Hebei University of Traditional Chinese Medicine, Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, People'sRepublic of China.
   Affiliated Hospital of Hebei University of Traditional Chinese Medicine, Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, People'sRepublic of China.
NR 0
TC 0
SN 1179-134
EI 1179-134
J9 Clin Epidemiol
PD OCT 12
PY 2021
VL 13
IS 
BP 907
EP 919
DI 10.2147/CLEP.S324193 
PG 12
UT PubMed:34629905
PM 34629905
DA 2021-10-12
ER

PT J
AU Yang, Y
   Wen, J
   Hong, J
AF Yang, Yulan
   Wen, Jian
   Hong, Jianyun
TI The Effects of Auricular Therapy for Cancer Pain: A Systematic Review and 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Review
AB OBJECTIVE: This study aims to systematically assess the efficacy and safety of 
   auricular therapy for cancer pain. METHODS: A systematic search was conducted 
   using PubMed, EMBASE, Cochrane library databases, CNKI, VIP, WanFang Data, and 
   CBM for randomized controlled trials (RCTs). Review Manager 5.3 was used for 
   meta-analysis. RESULTS: Of the 275 screened studies, nine RCTs involving 783 
   patients with cancer pain were systematically reviewed. Compared with drug 
   therapy, auricular therapy plus drug therapy has significant advantages both in 
   the effective rate for pain relief (RR = 1.40; 95% CI 1.22, 1.60; P < 0.00001) 
   and adverse effects rate (RR = 0.46; 95% CI 0.37, 0.58; P < 0.00001). And the 
   result revealed that auricular acupuncture had superior pain-relieving effects as 
   compared with sham auricular acupuncture (SMD = -1.45; 95% CI -2.80, -0.09; 
   P=0.04). However, the analysis indicated no difference on the effective rate for 
   pain relief between auricular therapy and drug therapy (RR = 1.24; 95% CI 0.71, 
   2.16; P=0.46). CONCLUSION: Our meta-analysis indicated that auricular therapy is 
   effective and safe for the treatment of cancer pain, and auricular therapy plus 
   drug therapy is more effective than drug therapy alone, whether in terms of pain 
   relief or adverse reactions. However, the included RCTs had some methodological 
   limitations; future large, rigor, and high-quality RCTs are still needed to 
   confirm the benefits of auricular therapy on cancer pain.
C1 Department of Acupuncture, Maoming People's Hospital, Maoming, Guangdong, China.
   Department of Oncology, Maoming People's Hospital, Maoming, Guangdong, China.
   Department of Acupuncture, Maoming People's Hospital, Maoming, Guangdong, China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD JUN 23
PY 2020
VL 2020
IS 
BP 1618767
EP 1618767
DI 10.1155/2020/1618767 
PG 0
UT PubMed:32565846
PM 32565846
DA 2020-06-23
ER

PT J
AU Weilert, F
AF Weilert, Frank
TI Prospective evaluation of simplified algorithm for EUS-guided intra-hepatic 
SO Surgical endoscopy
LA English
DT Journal Article
AB BACKGROUND: EUS-guided biliary drainage (EUS-BD) is technically challenging but 
   alternative method of therapeutic intervention when ERCP fails. OBJECTIVE: Assess 
   the feasibility, safety and risks of EUS-BD with intra-hepatic biliary access and 
   anterograde interventions using an algorithm to increase flexibility of 
   interventions, limit adverse events and improve procedural time. DESIGN: 
   Prospective observational cohort study. PATIENTS: 21 consecutive patients 
   underwent EUS-BD drainage for failed ERCP. MAIN OUTCOME MEASURES: Technical and 
   clinical success rates with adverse event rate using simplified algorithm. 
   RESULTS: Patient recruitment from June 2011-October 2013; mean age of 67.4 years, 
   predominantly male (70.5 %) with pancreatic cancer (52.4 %), cholangiocarcinoma 
   (14.3 %), other malignant biliary obstruction (9.5 %) and benign biliary 
   obstruction (23.8 %). Prior interventions included failed ERCP in 18/21 (85.7 %) 
   while 3/21 (14.3 %) had primary EUS-BD. Anterograde cholangiogram was achieved in 
   all patients. Technical success was achieved in 20/21 (95.2 %) with clinical 
   success was achieved in 19/21 (90.4 %). Placement of access wire was across the 
   ampulla in 10/20 (50 %) and into CBD or contra-lateral IHD in 10/20 (50 %). Tract 
   dilatation was accomplished in 17/20 (85 %) but required completion using 
   intra-hepatic needle knife in 3/20 (15 %). Anterograde interventions were 
   performed in 16/20 (80 %) but crossover to rendezvous in 3/20 (15 %) or 
   choledochoduodenostomy 1/20 (5 %). Three patients 3/21 (14.3 %) also had 
   endoscopic duodenal SEMS placement to relieve duodenal obstruction. Two patients 
   (9.5 %) had post-procedural bile leak and pain. CONCLUSION: EUS-guided 
   anterograde biliary drainage using the intra-hepatic access route has high 
   technical and clinical success with low adverse rate. We would promote a 
   simplified standardized algorithm, which gives flexibility of direct anterograde 
   interventions.
C1 Department of Gastroenterology, Waikato Hospital, Pembroke Street, Hamilton, 3200, New Zealand, frank.weilert@waikatodhb.health.nz.
NR 0
TC 0
SN 1432-221
EI 
J9 Surg Endosc
PD JUN 1
PY 2014
VL 28
IS 11
BP 3193
EP 9
DI 10.1007/s00464-014-3588-5 
PG -3184
WC Aged; Aged, 80 and over; Algorithms; Bile Duct Neoplasms; diagnosis; Bile Ducts, Intrahepatic; surgery; Cholangiopancreatography, Endoscopic Retrograde; Cholestasis; diagnosis; Drainage; methods; Endosonography; methods; Feasibility Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pancreatic Neoplasms; diagnosis; Prospective Studies; Reoperation; Surgery, Computer-Assisted; methods; Treatment Failure
UT PubMed:24879144
PM 24879144
DA 2014-06-01
ER

PT J
AU David, A
   Eilon, S
   Lev-Ari, S
   Frenkel, M
AF David, Adi
   Eilon, Sharon
   Lev-Ari, Shaked
   Frenkel, Moshe
TI [THERAPY IN PATIENTS AFFECTED BY BREAST AND PROSTATE CANCER].
SO Harefuah
LA heb
DT Review
AB OBJECTIVES: This study aims to identify and evaluate the treatment gaps in 
   patients undergoing endocrine therapy for breast and prostate tumors, and to 
   propose integrative solutions for unmet needs. METHODS: The article provides a 
   narrative review of three significant side effects of endocrine therapy among 
   breast and prostate cancer patients: vasomotor effects, joint pain and stiffness, 
   and sexual disorders. It also offers treatment options for these effects from the 
   field of complementary and integrative medicine. RESULTS: The adverse 
   consequences of endocrine treatments in breast and prostate cancer patients 
   reduce treatment compliance and significantly impair the patients' quality of 
   life. Evidence-based complementary and integrative medicine modalities, including 
   nutritional counseling, dietary supplements, homeopathic remedies, touch 
   therapies, acupuncture, and mind-body treatments, may improve the patients' 
   quality of life and alleviate the burden of side effects. CONCLUSIONS: There is a 
   need to improve the management of side effects unique to endocrine therapy. 
   Integrating supportive care with complementary and integrative medicine offers a 
   viable option to enhance the quality of life for these patients.
C1 Tal Center for Integrative Medicine, Supportive Care Unit, Chaim Sheba Medical Center, Ramat-Gan, Israel.
   Integrative Medicine Unit for Cancer Patients, Davidoff Center, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel.
   Ella Lemelbaum Institute for Immuno-Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
   Complementary and Integrative Medicine Service, Oncology Division, Rambam Health Care Campus, Haifa, Israel.
NR 0
TC 0
SN 
EI 0017-776
J9 Harefuah
PD JUL 24
PY 2025
VL 164
IS 7
BP 441
EP 446
DI 
PG 5
WC Humans; Quality of Life; Prostatic Neoplasms; therapy; Male; Breast Neoplasms; therapy; Complementary Therapies; methods; Female; Antineoplastic Agents, Hormonal; adverse effects; Integrative Medicine; methods
UT PubMed:40704870
PM 40704870
DA 2025-07-24
ER

PT J
AU Lam, CS
   Zhou, K
   Loong, HH
   Chung, VC
   Ngan, CK
   Cheung, YT
AF Lam, Chun Sing
   Zhou, Keary
   Loong, Herbert Ho-Fung
   Chung, Vincent Chi-Ho
   Ngan, Chun-Kit
   Cheung, Yin Ting
TI The Use of Traditional, Complementary, and Integrative Medicine in Cancer: 
SO Journal of medical Internet research
LA English
DT Journal Article
DE TCIM; cancer; cancer care; complementary; forums, digital health; integrative; machine learning; perceptions; social media; traditional; traditional, complementary, and integrative medicine
AB BACKGROUND: Patients with cancer are increasingly using forums and social media 
   platforms to access health information and share their experiences, particularly 
   in the use of traditional, complementary, and integrative medicine (TCIM). 
   Despite the popularity of TCIM among patients with cancer, few related studies 
   have used data from these web-based sources to explore the use of TCIM among 
   patients with cancer. OBJECTIVE: This study leveraged multiple forums and social 
   media platforms to explore patients' use, interest, and perception of TCIM for 
   cancer care. METHODS: Posts (in English) related to TCIM were collected from 
   Facebook, Twitter, Reddit, and 16 health forums from inception until February 
   2022. Both manual assessments and natural language processing were performed. 
   Descriptive analyses were performed to explore the most commonly discussed TCIM 
   modalities for each symptom and cancer type. Sentiment analyses were performed to 
   measure the polarity of each post or comment, and themes were identified from 
   posts with positive and negative sentiments. TCIM modalities that are emerging or 
   recommended in the guidelines were identified a priori. Exploratory 
   topic-modeling analyses with latent Dirichlet allocation were conducted to 
   investigate the patients' perceptions of these modalities. RESULTS: Among the 
   1,620,755 posts available, cancer-related symptoms, such as pain (10/10, 100% 
   cancer types), anxiety and depression (9/10, 90%), and poor sleep (9/10, 90%), 
   were commonly discussed. Cannabis was among the most frequently discussed TCIM 
   modalities for pain in 7 (70%) out of 10 cancer types, as well as nausea and 
   vomiting, loss of appetite, anxiety and depression, and poor sleep. A total of 7 
   positive and 7 negative themes were also identified. The positive themes included 
   TCIM, making symptoms manageable, and reducing the need for medication and their 
   side effects. The belief that TCIM and conventional treatments were not mutually 
   exclusive and intolerance to conventional treatment may facilitate TCIM use. 
   Conversely, TCIM was viewed as leading to patients' refusal of conventional 
   treatment or delays in diagnosis and treatment. Doctors' ignorance regarding TCIM 
   and the lack of information provided about TCIM may be barriers to its use. 
   Exploratory analyses showed that TCIM recommendations were well discussed among 
   patients; however, these modalities were also used for many other indications. 
   Other notable topics included concerns about the legalization of cannabis, 
   acupressure techniques, and positive experiences of meditation. CONCLUSIONS: 
   Using machine learning techniques, social media and health forums provide a 
   valuable resource for patient-generated data regarding the pattern of use and 
   patients' perceptions of TCIM. Such information will help clarify patients' needs 
   and concerns and provide directions for research on integrating TCIM into cancer 
   care. Our results also suggest that effective communication about TCIM should be 
   achieved and that doctors should be more open-minded to actively discuss TCIM use 
   with their patients.
C1 School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China (Hong Kong).
   School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China (Hong Kong).
   Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China (Hong Kong).
   School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China (Hong Kong).
   Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The 
   Data Science Program, Worcester Polytechnic Institute, Worcester, MA, United States.
   School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China (Hong Kong).
NR 0
TC 0
SN 1438-887
EI 1439-445
J9 J Med Internet Res
PD APR 21
PY 2023
VL 25
IS 
BP e45408
EP e45408
DI 10.2196/45408 
PG 1
WC Humans; Social Media; Integrative Medicine; Neoplasms; therapy; Data Mining; methods; Drug-Related Side Effects and Adverse Reactions
UT PubMed:37083752
PM 37083752
DA 2023-04-21
ER

PT J
AU Yan, Z
   MuRong, Z
   Huo, B
   Zhong, H
   Yi, C
   Liu, M
   Liu, M
AF Yan, Zhaobo
   MuRong, Zhimiao
   Huo, Bixiu
   Zhong, Huan
   Yi, Chun
   Liu, Mailan
   Liu, Mi
TI Acupuncture as a Complementary Therapy for Cancer-Induced Bone Pain: A Systematic 
SO Frontiers in pain research (Lausanne, Switzerland)
LA English
DT Journal Article
DE a systematic review; acupuncture; cancer pain; cancer-induced bone pain; meta-analysis
AB BACKGROUND: Cancer-induced bone pain (CIBP) is a special type of cancer pain and 
   lacks safe and effective treatments. Acupuncture is a potentially valuable 
   treatment for CIBP, studies evaluating the effect of acupuncture on CIBP have 
   increased significantly, but the safety and efficacy of acupuncture to control 
   CIBP remains controversial. OBJECTIVE: To provide the first meta-analysis to 
   evaluate the safety and efficacy of acupuncture in CIBP management. DATA SOURCES: 
   CNKI, CBM, Wanfang, VIP Database, PubMed, Embase, and Cochrane Library were 
   searched from their inception until 1 June 2022. STUDY SELECTION: RCTs with 
   primary bone tumor patients or other types of primary cancer companied by bone 
   metastases as the research subjects and to evaluate the efficacy of acupuncture 
   treatment alone or combined with the control treatment were included. Meanwhile, 
   RCTs should choose the pain score as the primary outcome and pain relief rate, 
   frequency of breakthrough pain, analgesic onset time, analgesia duration, quality 
   of life, and adverse events as reference outcomes. DATA COLLECTION AND ANALYSIS: 
   We designed a data-extraction form that was used to extract key information from 
   the articles. Data extraction study evaluation was conducted independently by two 
   reviewers, and a third reviewer would resolve any disagreements. The risk of bias 
   was assessed by the Cochrane Collaboration's tool for assessing the risk bias. 
   The quality of the evidence for main outcomes was evaluated by the GRADE system. 
   Mean differences (MD), relative risk (RR), and 95% confidence intervals (CIs) 
   were calculated. The forest plots were performed using the Review Manager 
   Software (5.3 version). Subgroup analysis was used to investigate the possible 
   sources of potential heterogeneity. Descriptive analysis was performed in case of 
   unacceptable clinical heterogeneity. RESULTS: Thirteen RCTs (with 1,069 patients) 
   were included, and all studies were at high risk of bias owing to lack of 
   blinding or other bias. Eleven studies evaluated the effectiveness of acupuncture 
   as a complementary therapy, and showed that acupuncture plus control treatment 
   (compared with control treatment) was connected with reduced pain intensity (MD = 
   -1.34, 95% CI -1.74 to -0.94; Q < 0.1; I (2) = 98%, P < 0.01). Subgroup analyses 
   based on acupoints type partly explain the potential heterogeneity. The results 
   also showed that acupuncture plus control treatment (compared with control 
   treatment) was connected with relieving pain intensity, increasing the pain 
   relief rate, reducing the frequency of breakthrough pain, shortening analgesic 
   onset time, extending the analgesic duration, and improving the quality of life. 
   We have no sufficient evidence to prove the effectiveness of acupuncture alone. 
   Four RCTs reported only adverse events related to opioids' side effects. Evidence 
   was qualified as "very low" because of low methodological quality, considerable 
   heterogeneity, or a low number of included studies. CONCLUSION: Acupuncture has a 
   certain effect as a complementary therapy on pain management of CIBP, which not 
   only mitigates the pain intensity but also improves the quality of life and 
   reduces the incidence of opioids' side effects, although the evidence level was 
   very low. In future, a larger sample size and rigorously designed RCTs are needed 
   to provide sufficient evidence to identify the efficacy and safety of acupuncture 
   as a treatment for CIBP.
C1 College of Acupuncture and Moxibustion, Hunan University of Chinese Medicine, Hunan, China.
   College of Acupuncture and Moxibustion, Hunan University of Chinese Medicine, Hunan, China.
   Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   College of Acupuncture and Moxibustion, Hunan University of Chinese Medicine, Hunan, China.
   Department of Pathology, Hunan University of Chinese Medicine, Hunan, China.
   College of Acupuncture and Moxibustion, Hunan University of Chinese Medicine, Hunan, China.
   College of Acupuncture and Moxibustion, Hunan University of Chinese Medicine, Hunan, China.
NR 0
TC 0
SN 2673-561
EI 2673-561
J9 Front Pain Res (Lausanne)
PD AUG 19
PY 2022
VL 3
IS 
BP 925013
EP 925013
DI 10.3389/fpain.2022.925013 
PG 0
UT PubMed:35978992
PM 35978992
DA 2022-08-19
ER

PT J
AU Yu, Q
   Wang, X
   Wu, J
   Zhang, Q
   Ying, X
   Ou, L
   Hu, H
   He, K
   Wu, L
   Jin, Z
   Shentu, J
   Dai, H
   Ma, R
   Hu, Q
   Han, D
AF Yu, Qintao
   Wang, Xinru
   Wu, Jiaqi
   Zhang, Qiyuan
   Ying, Xiaoqi
   Ou, Liming
   Hu, Hantong
   He, Kelin
   Wu, Lei
   Jin, Zongda
   Shentu, Jiajun
   Dai, Huifeng
   Ma, Ruijie
   Hu, Qimiao
   Han, Dexiong
TI Efficacy and Safety of Electroacupuncture for Postherpetic Neuralgia and 
SO Journal of pain research
LA English
DT Journal Article
DE biomarker; electroacupuncture; postherpetic neuralgia; randomized controlled trial; sham acupuncture; study protocol
AB INTRODUCTION: Postherpetic neuralgia (PHN) is a persistent neuropathic pain 
   condition that endures for at least 3 months following the onset of herpes 
   zoster, significantly impairing life quality of patients. Current PHN treatments 
   demonstrate limited efficacy, and the lack of reliable severity biomarkers 
   hinders effective clinical management. Electroacupuncture represents a promising 
   therapeutic approach for PHN, though comprehensive evidence supporting its 
   efficacy and safety is still needed. Furthermore, as objective indicators, the 
   role of serum biomarkers in assessments still requires further investigation. 
   METHODS: This multicenter, sham-controlled, randomized study will recruit 180 
   patients with PHN. Participants will be allocated in a 1:1:1 ratio to 
   electroacupuncture, sham acupuncture, or waiting-list groups via multicenter 
   stratified block randomization. Participants will receive 1-month of treatment 
   and 3-month follow-ups. The electroacupuncture group and the sham acupuncture 
   group will each receive 12 treatments. All participants will maintain their 
   pre-enrollment medication. Primary outcome is Numerical Rating Scale; secondary 
   outcomes include pain episode frequency, Hamilton Anxiety Scale, Hamilton 
   Depression Scale, The Short-Form 36 Health Survey, and changes of biomarkers 
   (Neuropeptide Y, Substance P, Tumor Necrosis Factor-α, Interleukin-10). A linear 
   mixed-effects model will be used to analyze data at different time points to 
   explore the efficacy of electroacupuncture and the correlation between serum 
   biomarkers and pain intensity. The predictive value of biomarkers for refractory 
   postherpetic neuralgia (NRS reduction <30% from baseline post-treatment) will be 
   assessed using ROC curves. CONCLUSION: The expected outcomes will clarify the 
   efficacy and safety of electroacupuncture for PHN. The study will also analyze 
   the correlation between serum biomarkers and pain symptoms and determine whether 
   serum biomarkers can serve as prognostic indicators for refractory postherpetic 
   neuralgia. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT06990854. 
   Registered on June 3, 2025. (https://clinicaltrials.gov/study/NCT06990854).
C1 The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   Department of Medical Affairs, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   Department of Acupuncture and Moxibustion, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, People's Republic of China.
   Department of Acupuncture and Moxibustion, Changxing County Traditional Chinese Medicine Hospital, Huzhou, Zhejiang, People's Republic of China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD NOV 7
PY 2025
VL 18
IS 
BP 5753
EP 5768
DI 10.2147/JPR.S559309 
PG 15
UT PubMed:41199896
PM 41199896
DA 2025-11-07
ER

PT J
AU Ji, Z
   Niu, H
   He, A
   Li, K
   Jia, J
   Zhang, M
   Liu, G
AF Ji, Zhe
   Niu, Heyuan
   He, Anqi
   Li, Kaiyu
   Jia, Jinyan
   Zhang, Maorun
   Liu, Gang
TI Research Hotspots and Trends in Acupuncture for Cancer:A bibliometric analysis 
SO Journal of multidisciplinary healthcare
LA English
DT Journal Article
DE VOSviewer; acupuncture; bibliometric analysis; cancer; citespace
AB BACKGROUND: Acupuncture is increasingly recognized as a promising intervention 
   modality in cancer treatment. Nevertheless, there has been a paucity of 
   systematic analysis and visualisation of relevant publications through 
   bibliometric methods. This paper conducts a bibliometric analysis of research on 
   acupuncture within the realm of oncological applications, aiming to explore its 
   prospects and emerging trends. METHODS: In this study, we analyzed 2117 documents 
   obtained from the Web of Science Core Collection (WOSCC) to examine the 
   correlations among authors, journals, institutions, countries, and keywords. This 
   analysis was conducted using the Bibliometric R package, CiteSpace, and VOSviewer 
   software. RESULTS: The evolution of acupuncture can be broadly divided into three 
   time periods: 2004-2008, 2009-2017 and 2018-2024. The WOSCC retrieved 2117 
   publications on acupuncture for cancer over the past 20 years. Among the top 10 
   institutions, seven were from the United States, two from China, and one from 
   Korea. Memorial Sloan Kettering Cancer Center had the highest number of 
   publications. At the same time, the journal INTEGRATIVE CANCER THERAPIES 
   published the most articles in this field. Keyword co-occurrence analysis 
   revealed four distinct clusters: "Alternative and Complementary Medicine for 
   Cancer", "Acupuncture for cancer-related fatigue and pain", "Acupressure for 
   anxiety, depression, and insomnia", "Improving quality of life for breast cancer 
   patients". The most recent keyword outbreaks included "sleep", "radiation induced 
   xerostomia", "recovery", "insomnia", and "induced peripheral neuropathy." Breast 
   cancer is the type of cancer for which acupuncture is most commonly used. 
   CONCLUSION: The future research focus will be on acupuncture as a treatment for 
   sleep disorders, the alleviation of radiotherapy complications and the 
   improvement of postoperative quality of life. Research on acupuncture in the 
   field of breast cancer is more extensive compared to other cancers. Therefore, it 
   is necessary to strengthen research on acupuncture in different cancer types.
C1 Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
   Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
   Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
   Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
   Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
   Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
   Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
NR 0
TC 0
SN 1178-239
EI 1178-239
J9 J Multidiscip Healthc
PD FEB 6
PY 2025
VL 18
IS 
BP 531
EP 547
DI 10.2147/JMDH.S494138 
PG 16
UT PubMed:39911755
PM 39911755
DA 2025-02-06
ER

PT J
AU Qi, P
   Zhou, M
   Han, W
   Li, H
   Min, L
   Li, J
   Sun, Z
   Yin, H
AF Qi, Pengfei
   Zhou, Mingyuan
   Han, Wenqing
   Li, Hongxiang
   Min, Lu
   Li, Jiaxin
   Sun, Zhongren
   Yin, Hongna
TI Mechanism of the analgesic effect of electroacupuncture on bone cancer pain 
SO Frontiers in neurology
LA English
DT Review
DE animal model; bone cancer pain; electroacupuncture; immunity; mechanism; morphine tolerance; neuroscience
AB This article summarizes the mechanism of the analgesic effect of 
   electroacupuncture (EA) on BCP by analyzing the progress of animal experimental 
   research on the treatment of bone cancer pain (BCP). As a kind of chronic 
   specific pain that both overlaps and incompletely coincides with inflammatory 
   pain and neuropathic pain, BCP is mostly clinically treated with opioids such as 
   morphine as the first-line analgesic for BCP, but the long-term application is 
   prone to a series of unavoidable side-effects, such as tolerance, dependence, as 
   well as cognitive impairment, nausea, constipation, and nephrotoxicity. 
   Therefore, there is an urgent need to seek safer and more effective treatment 
   measures. As a safe, reliable and consistently efficacious analgesic, EA produces 
   analgesic effects in inflammatory pain, neuropathic pain and BCP. EA not only 
   attenuates the nociceptive sensitization of BCP by modulating the release of 
   nociception-related neurotransmitters and receptors in the nervous system, but 
   also exerts analgesic effects on BCP by modulating the expression of inflammatory 
   factors in the immune system, inhibiting glial cell activation, and T cell 
   proliferation. At present, EA research on the analgesic mechanism of BCP has made 
   some progress, but there are still problems that need to be solved, such as the 
   lack of standardization of acupoints and parameters, weak clinical validation, a 
   single research model, and limitations in the perspective of analgesic mechanism 
   research. It is suggested that future studies should be based on databases such 
   as AcuEBase v1.0 to develop standardized EA acupoint combinations and frequency 
   parameters to provide a scientific basis for EA standardization. At the same 
   time, the sample size should be expanded and the experimental design should be 
   improved in order to promote the transformation of animal experiments into 
   clinical applications. In addition, it should be expanded to more types of cancer 
   bone metastasis pain models to verify the consistency of the analgesic effect of 
   EA in different BCP models. Future studies could also explore the multi-target 
   synergistic analgesic effects of EA from a microbial-immune axis perspective with 
   the help of tools such as MicrobeTCM. And optimize the treatment plan of BCP 
   through EA combined with drug therapy. It is believed that with the progress of 
   science and technology as well as the continuous exploration of human beings, the 
   complex mechanism of BCP will be overcome by human beings eventually.
C1 Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Heilongjiang University of Chinese Medicine, Harbin, China.
   Second Hospital of Heilongjiang University of Traditional Chinese Medicine, 
NR 0
TC 0
SN 1664-229
EI 1664-229
J9 Front Neurol
PD DEC 26
PY 2025
VL 16
IS 
BP 1693978
EP 1693978
DI 10.3389/fneur.2025.1693978 
PG 0
UT PubMed:41451423
PM 41451423
DA 2025-12-26
ER

PT J
AU Lu, W
AF Lu, Weidong
TI Axon Degeneration and Inflammation in Neuropathy: The Role of Acupuncture.
SO Medical acupuncture
LA English
DT Journal Article
DE axon degeneration; breast cancer; electroacupuncture; inflammation; pain management acupuncture; peripheral neuropathy
AB Chemotherapy-induced peripheral neuropathy (CIPN) induces debilitating long-term 
   side-effects in breast cancer-survivors. This article describes some of the 
   more-recent research in this area including a randomized controlled pilot trial 
   the current author and colleagues performed to assess feasibility, safety, and 
   effectiveness of acupuncture for treating CIPN in this population. In this 
   randomized pilot trial of 40 breast-cancer survivors with CIPN after adjuvant 
   taxane therapy, an 8-week acupuncture intervention (versus usual care) led to a 
   statistically and clinically significant reduction in subjective sensory 
   symptoms, including neuropathic pain and paresthesia. Given the lack of effective 
   therapies and given the established safety profile of acupuncture, clinicians may 
   consider acupuncture as a treatment option for mild-to-moderate CIPN in practice. 
   Additional larger studies are needed to confirm these findings.
C1 Leonard P. Zakim Center for Integrative Therapies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD DEC 29
PY 2020
VL 32
IS 6
BP 398
EP 399
DI 10.1089/acu.2020.1496 
PG 1
UT PubMed:33362898
PM 33362898
DA 2020-12-29
ER

PT J
AU Wong, RK
   James, JL
   Sagar, S
   Wyatt, G
   Nguyen-Tân, PF
   Singh, AK
   Lukaszczyk, B
   Cardinale, F
   Yeh, AM
   Berk, L
AF Wong, Raimond K W
   James, Jennifer L
   Sagar, Stephen
   Wyatt, Gwen
   Nguyen-Tân, Phuc Felix
   Singh, Anurag K
   Lukaszczyk, Barbara
   Cardinale, Francis
   Yeh, Alexander M
   Berk, Lawrence
TI Phase 2 results from Radiation Therapy Oncology Group Study 0537: a phase 2/3 
SO Cancer
LA English
DT Journal Article
AB BACKGROUND: In this phase 2 component of a multi-institutional, phase 2/3, 
   randomized trial, the authors assessed the feasibility and preliminary efficacy 
   of acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) in 
   reducing radiation-induced xerostomia. METHODS: Patients with cancer of the head 
   and neck who were 3 to 24 months from completing radiotherapy with or without 
   chemotherapy (RT ± C) and who were experiencing xerostomia symptoms with basal 
   whole saliva production ≥0.1 mL per minute and were without recurrence were 
   eligible. Patients received twice weekly ALTENS sessions (24 sessions over 12 
   weeks) using a proprietary electrical stimulation unit. The primary study 
   objective was to assess the feasibility of ALTENS treatment. Patients were 
   considered compliant if 19 of 24 ALTENS sessions were delivered, and the targeted 
   compliance rate was 85%. Secondary objectives measured treatment-related 
   toxicities and the effect of ALTENS on overall radiation-induced xerostomia 
   burden using the University of Michigan Xerostomia-Related Quality of Life Scale 
   (XeQOLS). RESULTS: Of 48 accrued patients, 47 were evaluable. The median age was 
   60 years, 84% of patients were men, 70% completed RT ± C for >12 months, and 21% 
   had previously received pilocarpine. Thirty-four patients completed all 24 ALTENS 
   sessions, 9 patients completed 20 to 23 sessions, and 1 patient completed 19 
   sessions, representing a 94% total compliance rate. Six-month XeQOLS scores were 
   available for 35 patients and indicated that 30 patients (86%) achieved a 
   positive treatment response with a mean ± standard deviation reduction of 35.9% ± 
   36.1%. Five patients developed grade 1 or 2 gastrointestinal toxicity, and 1 had 
   a grade 1 pain event. CONCLUSIONS: The current results indicated that ALTENS 
   treatment for radiation-induced xerostomia can be delivered uniformly in a 
   cooperative, multicenter setting and produces possible beneficial treatment 
   response. Given these results, the phase 3 component of this study was initiated.
C1 McMaster University, Department of Oncology, Juravinski Cancer Center, Hamilton, Ontario, Canada. raimond.wong@jcc.hhsc.ca
NR 0
TC 0
SN 1097-014
EI 0008-543
J9 Cancer
PD JAN 19
PY 2012
VL 118
IS 17
BP 4244
EP 52
DI 10.1002/cncr.27382 
PG -4192
WC Acupuncture; methods; Adult; Aged; Aged, 80 and over; Female; Head and Neck Neoplasms; radiotherapy; Humans; Male; Middle Aged; Pilocarpine; therapeutic use; Quality of Life; Radiation Injuries; therapy; Radiotherapy; adverse effects; Transcutaneous Electric Nerve Stimulation; adverse effects; Xerostomia; etiology; Young Adult
UT PubMed:22252927
PM 22252927
DA 2012-01-19
ER

PT J
AU Ruan, A
   Wang, Q
   Ma, Y
   Zhang, D
   Yang, L
   Wang, Z
   Xie, Q
   Yin, Y
AF Ruan, Anmin
   Wang, Qingfu
   Ma, Yufeng
   Zhang, Dong
   Yang, Lili
   Wang, Zhongpeng
   Xie, Qi
   Yin, Yueshan
TI Efficacy and Mechanism of Electroacupuncture Treatment of Rabbits With Different 
SO Frontiers in physiology
LA English
DT Journal Article
DE electro-acupuncture; innate immune response; knee osteoarthritis; mechanism research; signaling pathway
AB Knee osteoarthritis (KOA) is a chronic degenerative bone and joint disease, which 
   is often clinically manifested as pain, joint swelling, and deformity. Its 
   pathological manifestations are mainly synovial inflammation and cartilage 
   degeneration. This study aims to investigate the efficacy of electro-acupuncture 
   (EA) on model rabbits with varying degrees of KOA and to study the mechanism of 
   EA on KOA based on the innate immune response. Mild and moderate rabbit KOA 
   models were established using a modified Hluth method, and EA was given to both 
   the mild and moderate model groups. The Lequesne-MG index was used to evaluate 
   the behavioral changes in the rabbits before and after EA treatment. 
   Morphological changes in the synovial membrane and cartilage of each group were 
   observed by H&E staining. The Mankin scoring standard and the Krenn scoring 
   standard were used to score the pathology of the cartilage tissue and synovial 
   tissue, respectively. The inflammatory factors and metalloproteinases were 
   detected in the serum of each group by ELISA. The protein and messenger RNA 
   (mRNA) expressions of important elements related to Toll-like receptors 
   (TLRs)-mediated innate immune response in the synovial tissue were detected by 
   Western blot and quantitative PCR (qPCR). The Lequesne-MG index score of the 
   rabbits gradually increased with the modeling prolonged but decreased 
   significantly after EA treatment, indicating that EA has a better effect on 
   alleviating the pain and improving the dysfunction. The morphological analysis 
   showed that the inflammation of and the damage to the synovial membrane and the 
   cartilage tissue gradually deteriorated with the modeling prolonged. However, the 
   synovial membrane inflammation was significantly relieved after EA treatment, and 
   the cartilage injury showed signs of repair. The ELISA analysis showed that, with 
   the modeling prolonged, the serum-related inflammatory factors and mechanism of 
   metalloproteinases gradually increased but decreased after EA treatment. The 
   tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and matrix 
   metalloproteinase3 (MMP3) of EA1 group were significantly lower than those of EA2 
   group. Both Western blot and qPCR results showed that the protein and mRNA 
   expressions of the elements related to the innate immune response in the synovial 
   membrane increased gradually with the modeling prolonged, but decreased 
   significantly after EA treatment. Additionally, the expression of some components 
   in EA1 group was significantly lower than that in EA2 group. These results 
   confirm that synovial inflammation gradually aggravated with time from the early 
   to mid-stage of KOA. EA alleviated the inflammation and histological changes in 
   KOA rabbits by inhibiting the TLRs-mediated innate synovial immune response. This 
   suggests that using EA in the early stage of KOA may achieve a desirable 
   efficacy.
C1 Department of Orthopedics, Beijing Longfu Hospital, Beijing, China.
   Department of Tendon and Injury, The Third Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
   Department of Tendon and Injury, The Third Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
   Department of General Surgery, The Second Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
   Department of Orthopedics, Beijing Longfu Hospital, Beijing, China.
   Acupuncture and Moxibustion Department, The Third Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
   Graduate School, Beijing University of Chinese Medicine, Beijing, China.
   Acupuncture and Moxibustion Department, The Third Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
NR 0
TC 0
SN 1664-042
EI 1664-042
J9 Front Physiol
PD AUG 24
PY 2021
VL 12
IS 
BP 642178
EP 642178
DI 10.3389/fphys.2021.642178 
PG 0
UT PubMed:34421630
PM 34421630
DA 2021-08-24
ER

PT J
AU Deng, GE
   Rausch, SM
   Jones, LW
   Gulati, A
   Kumar, NB
   Greenlee, H
   Pietanza, MC
   Cassileth, BR
AF Deng, Gary E
   Rausch, Sarah M
   Jones, Lee W
   Gulati, Amitabh
   Kumar, Nagi B
   Greenlee, Heather
   Pietanza, M Catherine
   Cassileth, Barrie R
TI Complementary therapies and integrative medicine in lung cancer: Diagnosis and 
SO Chest
LA English
DT Journal Article
AB BACKGROUND: Physicians are often asked about complementary therapies by patients 
   with cancer, and data show that the interest in and use of these therapies among 
   patients with cancer is common. Therefore, it is important to assess the current 
   evidence base on the benefits and risks of complementary therapies (modalities 
   not historically used in modern Western medicine). METHODS: A systematic 
   literature review was carried out and recommendations were made according to the 
   American College of Chest Physicians Evidence-Based Clinical Practice Guidelines 
   development methodology. RESULTS: A large number of randomized controlled trials, 
   systematic reviews, and meta-analyses, as well as a number of prospective cohort 
   studies, met the predetermined inclusion criteria. These trials addressed many 
   different issues pertaining to patients with lung cancer, such as symptoms of 
   anxiety, mood disturbance, pain, quality of life, and treatment-related side 
   effects. The available data cover a variety of interventions, including 
   acupuncture, nutrition, mind-body therapies, exercise, and massage. The body of 
   evidence supports a series of recommendations. An evidenced-based approach to 
   modern cancer care should integrate complementary therapies with standard cancer 
   therapies such as surgery, radiation, chemotherapy, and best supportive care 
   measures. CONCLUSIONS: Several complementary therapy modalities can be helpful in 
   improving the overall care of patients with lung cancer.
C1 Memorial Sloan-Kettering Cancer Center, New York, NY. 
   University of Florida College of Medicine, Jacksonville, FL.
   Duke Cancer Institute, Durham, NC.
   Memorial Sloan-Kettering Cancer Center, New York, NY.
   Moffitt Cancer Center and Research Institute, Tampa, FL.
   Columbia University, New York, NY.
   Memorial Sloan-Kettering Cancer Center, New York, NY.
   Memorial Sloan-Kettering Cancer Center, New York, NY.
EM dengg@mskcc.org
NR 0
TC 0
SN 1931-354
EI 
J9 Chest
PD MAY 10
PY 2013
VL 143
IS 5 Suppl
BP e420S
EP e436S
DI 10.1378/chest.12-2364 
PG 1
WC Complementary Therapies; Evidence-Based Medicine; Humans; Integrative Medicine; Lung Neoplasms; psychology; Quality of Life
UT PubMed:23649450
PM 23649450
DA 2013-05-10
ER

PT J
AU Lin, LL
   Li, HP
   Yang, JW
   Hao, XW
   Yan, SY
   Wang, LQ
   Yu, FT
   Shi, GX
   Liu, CZ
AF Lin, Lu-Lu
   Li, Hong-Ping
   Yang, Jing-Wen
   Hao, Xiao-Wan
   Yan, Shi-Yan
   Wang, Li-Qiong
   Yu, Fang-Ting
   Shi, Guang-Xia
   Liu, Cun-Zhi
TI Acupuncture for Psychological Disorders Caused by Chronic Pain: A Review and 
SO Frontiers in neuroscience
LA English
DT Review
DE acupuncture; biological mechanisms; chronic pain; clinical trials; psychological states; review
AB Accumulating evidence supports an association between chronic pain and 
   psychological disorders, a connection that seems to be bidirectional. Treating 
   both the pain and psychological conditions together is essential for effective 
   treatment outcomes. Acupuncture is a somatosensory-guided mind-body therapy that 
   can tackle the multidimensional nature of pain with fewer or no serious adverse 
   effects. In this review, we discuss the use of acupuncture in some conditions 
   with a high incidence of psychological disorders caused by chronic pain: 
   headache, musculoskeletal pain, low back pain, and cancer pain, focusing on the 
   effect and potential mechanisms of acupuncture. Overall clinical studies 
   indicated that acupuncture might effectively contribute to management of 
   psychological disorders caused by chronic pain. Mechanistic studies showed that 
   acupuncture significantly alleviated such psychological disorders by regulating 
   the activity of amygdala and insula, and regulating functional connectivity of 
   insular and limbic regions/medial prefrontal cortex in humans and the 
   corresponding animal models. In addition, 5-HT in the dorsal raphe nucleus, 
   opioid receptors in the cingulate cortex, and plasma met-enkephalin are involved 
   in acupuncture relief of pain and psychological symptoms. Substantial evidences 
   from animal and human research support a beneficial effect of acupuncture in 
   psychological disorders caused by chronic pain.
C1 International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
   International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Beijing, China.
   School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
NR 0
TC 0
SN 1662-453
EI 1662-454
J9 Front Neurosci
PD FEB 16
PY 2021
VL 14
IS 
BP 626497
EP 626497
DI 10.3389/fnins.2020.626497 
PG 0
UT PubMed:33584181
PM 33584181
DA 2021-02-16
ER

PT J
AU Pachman, DR
   Watson, JC
   Loprinzi, CL
AF Pachman, Deirdre R
   Watson, James C
   Loprinzi, Charles L
TI Therapeutic strategies for cancer treatment related peripheral neuropathies.
SO Current treatment options in oncology
LA English
DT Review
AB Chemotherapy-induced peripheral neuropathy (CIPN) is a common toxicity associated 
   with multiple chemotherapeutic agents. CIPN may have a detrimental impact on 
   patients' quality of life and functional ability, as well as result in 
   chemotherapy dose reductions. Although symptoms of CIPN can improve with 
   treatment completion, symptoms may persist. Currently, the treatment options for 
   CIPN are quite limited. Duloxetine, a serotonin-norepinephrine reuptake 
   inhibitor, has the most evidence supporting its use in the treatment of CIPN. 
   Other agents with potential benefit for the treatment of established CIPN include 
   gabapentinoids, venlafaxine, tricyclic antidepressants, and a topical gel 
   consisting of the combination of amitriptyline, ketamine, and baclofen; none of 
   these, however, has been proven to be helpful and ongoing/future studies may well 
   show that they are not beneficial. The use of these agents is often based on 
   their efficacy in the treatment of non-CIPN neuropathic pain, but this does not 
   necessarily mean that they will be helpful for CIPN-related symptoms. Other 
   nonpharmacologic interventions including acupuncture and Scrambler therapy are 
   supported by positive preliminary data; however, further larger, 
   placebo-controlled trial data are needed to confirm or refute their 
   effectiveness.
C1 Mayo Clinic Rochester, 200 First Street SW, Rochester, MN, 55905, USA, pachman.deirdre@mayo.edu.
NR 0
TC 0
SN 1534-627
EI 
J9 Curr Treat Options Oncol
PD AUG 15
PY 2014
VL 15
IS 4
BP 567
EP 80
DI 10.1007/s11864-014-0303-7 
PG -487
WC Antineoplastic Agents; adverse effects; Humans; Neoplasms; complications; Peripheral Nervous System Diseases; etiology
UT PubMed:25119581
PM 25119581
DA 2014-08-15
ER

PT J
AU Ehret, CJ
   Almodallal, Y
   Le-Rademacher, JG
   Martin, NA
   Moynagh, MR
   Rajotia, A
   Jatoi, A
AF Ehret, Christopher J
   Almodallal, Yahya
   Le-Rademacher, Jennifer G
   Martin, Nichole A
   Moynagh, Michael R
   Rajotia, Arush
   Jatoi, Aminah
TI Hiccups in patients with cancer: a multi-site, single-institution study of 
SO BMC cancer
LA English
DT Journal Article
DE Complications; Hiccups; Morbidity; Palliation
AB BACKGROUND: To our knowledge, previous studies have not investigated hiccups in 
   patients with cancer with detailed patient-level data with the goal of capturing 
   a broad spectrum of hiccup symptomatology. METHODS: This multi-site, single 
   institution study examined consecutive medical records to better understand 
   hiccups in patients with cancer. RESULTS: A total of 320 patients are the focus 
   of this report. The median age of patients when hiccups were first reported in 
   the medical record was 63 years (range: 21, 97 years) with 284 (89%) men and 36 
   (11%) women. The most common diagnose was gastrointestinal cancer. Hiccups most 
   frequently occurred daily, as seen in 194 patients (62%), and the most common 
   duration was less than 1 week, as seen in 146 patients (47%). However, nine 
   patients had had daily hiccups for greater than 6 weeks, and 5 had symptoms for 
   years. Cited etiology was non-chemotherapy medications in 36 (11%) and cancer 
   chemotherapy in 19 (6%). Complications occurred in approximately a third and 
   included insomnia in 51 patients (16%); hospitalization or emergency department 
   visit in 34 (11%); and musculoskeletal pain in 23 (7%). Baclofen was the single 
   most prescribed agent for hiccup palliation, but 100 patients received more than 
   one medication. Medical procedures, which included acupuncture, paracentesis, or 
   phrenic nerve block, were performed in 5 patients. In 234 patients (73%), the 
   medical record documented hiccup cessation. CONCLUSIONS: Hiccups appear to be 
   highly problematic in a small subset of patients with cancer with no well-defined 
   palliative approaches.
C1 Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
   Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
   Division of Clinical Trials and Biostatistics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
   Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
   Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
   Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
   Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. jatoi.aminah@mayo.edu.
NR 0
TC 0
SN 1471-240
EI 
J9 BMC Cancer
PD JUN 16
PY 2022
VL 22
IS 1
BP 659
EP 659
DI 10.1186/s12885-022-09760-5 
PG 0
WC Baclofen; therapeutic use; Female; Hiccup; complications; Humans; Male; Neoplasms; drug therapy; Palliative Care; Sleep Initiation and Maintenance Disorders; complications
UT PubMed:35705907
PM 35705907
DA 2022-06-16
ER

PT J
AU Narayanan, S
   Reddy, A
   Lopez, G
   Liu, W
   Ali, S
   Bruera, E
   Cohen, L
   Yennurajalingam, S
AF Narayanan, Santhosshi
   Reddy, Akhila
   Lopez, Gabriel
   Liu, Wenli
   Ali, Sara
   Bruera, Eduardo
   Cohen, Lorenzo
   Yennurajalingam, Sriram
TI Sleep disturbance in cancer patients referred to an ambulatory integrative 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Complementary medicine; Insomnia; Integrative oncology; Patient-reported outcomes; Sleep disturbance
AB BACKGROUND: Sleep disturbance (SD) is highly prevalent in oncology and negatively 
   affects quality of life and mortality. Evidence supports the use of integrative 
   oncology (IO) practices to treat SD, but there is limited published data on the 
   characteristics of SD and factors associated with SD in IO. We determined the 
   prevalence, severity, and factors associated with SD among cancer patients seen 
   in an ambulatory IO consultation. METHODS: Patients with cancer referred for 
   initial outpatient IO consultation in 2017 were eligible. Patient demographics, 
   clinical characteristics, and patient-reported outcomes (Edmonton Symptom 
   Assessment Scale (ESAS), Measure Yourself Concerns and Wellbeing (MYCaW), 
   PROMIS-10) were retrospectively reviewed. RESULTS: One thousand five hundred 
   twenty patients were included in the analysis. The majority (70%) were women with 
   breast cancer (42%). Nine hundred seventy-one (64%) patients reported significant 
   SD with ESAS Sleep ≥ 4, yet only 11% expressed poor sleep as their primary or 
   secondary concern for the IO consultation. The median SD (IQR) was 5 (3,7). ESAS 
   scores for fatigue (adjusted OR 1.16; CI 1.07-1.26, p < 0.001), pain (adjusted OR 
   1.07; CI 1.00-1.15, p < 0.05), hot flashes (adjusted OR 1.14; CI 1.07-1.22, 
   p < 0.001), well-being (adjusted OR 1.33; CI 1.22-1.46, p < 0.001), and 
   psychological distress score (anxiety and depression) (adjusted OR 1.16; CI 
   1.01-1.11, p < 0.01) were independently associated with SD in multivariate 
   analysis. Acupuncture was the most frequent intervention prescribed, 175 (35%). 
   Other modalities included oncology massage (15%), health psychology (5%), and 
   meditation (1%). CONCLUSIONS: Although 64% of patients seeking IO consultation 
   reported clinically significant SD, only 11% were seeking integrative approaches 
   for managing SD. ESAS fatigue, hot flashes, well-being, and psychological 
   symptoms were significantly associated with SD.
C1 Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer, Unit 1414, 1515 Holcombe Blvd., Houston,TX, 77030, USA. snarayanan2@mdanderson.org.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer, Unit 1414, 1515 Holcombe Blvd., Houston,TX, 77030, USA.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer, Unit 1414, 1515 Holcombe Blvd., Houston,TX, 77030, USA.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer, Unit 1414, 1515 Holcombe Blvd., Houston,TX, 77030, USA.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer, Unit 1414, 1515 Holcombe Blvd., Houston,TX, 77030, USA.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer, Unit 1414, 1515 Holcombe Blvd., Houston,TX, 77030, USA.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer, Unit 1414, 1515 Holcombe Blvd., Houston,TX, 77030, USA.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer, Unit 1414, 1515 Holcombe Blvd., Houston,TX, 77030, USA.
NR 0
TC 0
SN 1433-733
EI 
J9 Support Care Cancer
PD NOV 12
PY 2021
VL 30
IS 3
BP 2417
EP 2425
DI 10.1007/s00520-021-06668-x 
PG 8
WC Breast Neoplasms; Female; Humans; Integrative Oncology; Male; Neoplasms; complications; Quality of Life; Referral and Consultation; Retrospective Studies; Sleep
UT PubMed:34762218
PM 34762218
DA 2021-11-12
ER

PT J
AU Zhang, YL
   Mao, JJ
   Li, QS
   Weitzman, M
   Liou, KT
AF Zhang, Yi Lily
   Mao, Jun J
   Li, Q Susan
   Weitzman, Matthew
   Liou, Kevin T
TI Battlefield acupuncture for chronic musculoskeletal pain in cancer survivors: a 
SO Frontiers in pain research (Lausanne, Switzerland)
LA English
DT Journal Article
DE auricular acupuncture; battlefield acupuncture; cancer; care delivery; clinical trial; pain
AB INTRODUCTION: Battlefield Acupuncture (BFA), a standardized auricular acupuncture 
   protocol, is widely used for pain in the military but is not well-studied in 
   oncology. This study examined cancer survivors who received BFA for pain. 
   METHODS: This is a secondary analysis of a randomized trial that compared the 
   effectiveness of BFA and electroacupuncture vs. usual care for chronic 
   musculoskeletal pain in cancer survivors. This study focused on participants 
   randomized to BFA. Participants received 10 weekly treatments. Needles were 
   placed until one of these stop conditions were satisfied: ten needles were 
   administered; pain severity decreased to ≤1 out of 10; patient declined further 
   needling, or vasovagal reaction was observed. Pain severity was assessed using 
   Brief Pain Inventory. Responders were those with ≥30% pain severity reduction. We 
   examined pain location, BFA stop reason, and pain reduction of participants 
   during the first session. We also examined which factors predicted responder 
   status after the first session (week 1) or the full treatment (week 12). RESULTS: 
   Among 143 randomized to BFA, most common pain locations were lower back (30.8%) 
   and knee/leg (18.2%). Of 138 who initiated treatment, 41 (30.0%) received ten 
   needles; 81 (59.1%) achieved pain ≤1; 14 (10.2%) declined further needling; and 1 
   (0.7%) had vasovagal reaction. BFA reduced pain severity by 2.9 points (95% CI 
   2.6 to 3.2) after the first session (P < 0.001). After adjusting for baseline 
   pain severity, responders at week 1 were 2.5 times more likely to be responders 
   at week 12, compared to those who were non-responders at week 1 (AOR 2.5, 95% CI 
   1.02 to 6.11, P = 0.04). Among those who achieved pain ≤1, 74% were responders at 
   week 12, a higher proportion compared to the proportion of responders among those 
   who received ten needles (39.5%), those who declined further needling (50%), and 
   those with vasovagal reaction (0.0%) (P = 0.001). Those with pain in proximal 
   joints had a higher proportion of responders at week 12, compared to those with 
   pain in distal joints (64.2% vs. 20%, P = 0.008). CONCLUSION: Specific factors 
   may predict the likelihood of achieving meaningful pain reduction from BFA. 
   Understanding these predictors could inform precision pain management and 
   acupuncture delivery models.
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
NR 0
TC 0
SN 2673-561
EI 2673-561
J9 Front Pain Res (Lausanne)
PD DEC 20
PY 2023
VL 4
IS 
BP 1279420
EP 1279420
DI 10.3389/fpain.2023.1279420 
PG 0
UT PubMed:38116187
PM 38116187
DA 2023-12-20
ER

PT J
AU Yu, JN
   Guo, CQ
   Hu, B
   Liu, NG
   Sun, HM
   Xu, H
   Wu, HX
   Guo, Y
   Liang, CX
   Chen, ZX
   Li, XH
AF Yu, Jia Ni
   Guo, Chang Qing
   Hu, Bo
   Liu, Nai Gang
   Sun, Hong Mei
   Xu, Hong
   Wu, Hai Xia
   Guo, Yan
   Liang, Chu Xi
   Chen, Zhan Xia
   Li, Xiao Hong
TI Effects of acupuncture knife on inflammatory factors and pain in third lumbar 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB The aim of this paper was to explore the long-term effects and pain relief 
   mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process 
   syndrome. Forty SD rats were randomized into control, model, electroacupuncture 
   (EA), and acupuncture knife (AK) group. Except control rats, other rats were 
   subjected to an operation to emulate L3 transverse process syndrome. Fourteen 
   days after the operation, EA and AK rats were given electroacupuncture and 
   acupuncture knife treatments, respectively. Fifty-six days after the operation, 
   enzyme-linked immunosorbent assay was used to measure substance P (SP), 
   5-hydroxytryptamine (5-HT), interleukin-1β (IL-1β), interleukin-10 (IL-10), tumor 
   necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) in peripheral 
   blood. The tail flick test was used to observe pain threshold. We found that rats 
   with the simulation operation had significantly higher levels of SP, 5-HT, IL-1, 
   IL-10, TNF-α, and TGF-β, while the AK rats had lower levels. In addition, the 
   pain threshold of AK rats was similar to that of control rats. AK pretreatment 
   could alleviate pain through modulating inflammatory response.
C1 School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
   School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
   Acupuncture & Moxibustion and Physiotherapy Department, Beijing Shuili Hospital, No. 19 Yu Yuan Tan South Road, Haidian District, Beijing 100036, China.
   Acupuncture and Moxibustion Department, China-Japan Friendship Hospital, No. 2 The Ying Hua Yuan East Street, Chaoyang District, Beijing 100029, China.
   School of Basic Medical Sciences, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
   School of Basic Medical Sciences, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
   School of Basic Medical Sciences, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
   School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
   School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
   School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
   School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD DEC 30
PY 2014
VL 2014
IS 
BP 892406
EP 892406
DI 10.1155/2014/892406 
PG 0
UT PubMed:25544854
PM 25544854
DA 2014-12-30
ER

PT J
AU Sarradon-Eck, A
   Bouhnik, AD
   Rey, D
   Bendiane, MK
   Huiart, L
   Peretti-Watel, P
AF Sarradon-Eck, Aline
   Bouhnik, Anne-Déborah
   Rey, Dominique
   Bendiane, Marc-Karim
   Huiart, Laetitia
   Peretti-Watel, Patrick
TI Use of non-conventional medicine two years after cancer diagnosis in France: 
SO Journal of cancer survivorship : research and practice
LA English
DT Journal Article
DE Cancer survivors; Cohort study; Complementary and alternative medicine; Coping; France; Integrative medicine
AB PURPOSE: The purpose of this study was to assess the use of non-conventional 
   medicine (NCM) in a representative sample of French patients 2 years after cancer 
   diagnosis. METHODS: The study was based on data obtained in the VICAN survey 
   (2012) on a representative sample of 4349 patients 2 years after cancer 
   diagnosis. Self-reported data were collected at telephone interviews with 
   patients. The questionnaire addressed the various types of non-conventional 
   treatments used at the time of the survey. RESULTS: Among the participants, 16.4% 
   reported that they used NCM, and 45.3% of this group had not used NCM before 
   cancer diagnosis (new NCM users). Commonly, NCMs used were homeopathy (64.0%), 
   acupuncture (22.1%), osteopathy (15.1%), herbal medicine (8.1%), diets (7.3%) and 
   energy therapies (5.8%). NCM use was found to be significantly associated with 
   younger age, female gender and a higher education level. Previous NCM use was 
   significantly associated with having a managerial occupation and an expected 
   5-year survival rate ≥80% at diagnosis; recent NCM use was associated with cancer 
   progression since diagnosis, impaired quality of life and higher pain reports. 
   CONCLUSION: This is the first study on NCM use 2 years after cancer diagnosis in 
   France. In nearly half of the NCM users, cancer diagnosis was one of the main 
   factors which incited patients to use NCM. Apart from the NCM users' 
   socioeconomic profile, the present results show that impaired health was a 
   decisive factor: opting for unconventional approaches was therefore a pragmatic 
   response to needs which conventional medicine fails to meet during the course of 
   the disease. IMPLICATIONS FOR CANCER SURVIVORS: Better information of patients 
   and caregivers is needed to allow access to these therapies to a larger 
   population of survivors.
C1 Aix Marseille Univ, INSERM, IRD, SESSTIM, "Economics & Social Sciences Applied to Health & Analysis of Medical Information", Marseille, France.aline.sarradon@inserm.fr.
   Inst Paoli Calmettes, SESSTIM, Marseille, France. aline.sarradon@inserm.fr.
   Aix Marseille Univ, INSERM, IRD, SESSTIM, "Economics & Social Sciences Applied to Health & Analysis of Medical Information", Marseille, France.
   Aix Marseille Univ, INSERM, IRD, SESSTIM, "Economics & Social Sciences Applied to Health & Analysis of Medical Information", Marseille, France.
   ORS PACA, Southeastern Health Regional Observatory, Marseille, France.
   Aix Marseille Univ, INSERM, IRD, SESSTIM, "Economics & Social Sciences Applied to Health & Analysis of Medical Information", Marseille, France.
   ORS PACA, Southeastern Health Regional Observatory, Marseille, France.
   Aix Marseille Univ, INSERM, IRD, SESSTIM, "Economics & Social Sciences Applied to Health & Analysis of Medical Information", Marseille, France.
   CHU de la Réunion, Unité de Soutien Méthodologique, Saint Denis, France.
   CHU de la Réunion, INSERM, CIC 1410, Saint-Pierre, France.
   Aix Marseille Univ, INSERM, IRD, SESSTIM, "Economics & Social Sciences Applied to Health & Analysis of Medical Information", Marseille, France.
   ORS PACA, Southeastern Health Regional Observatory, Marseille, France.
NR 0
TC 0
SN 1932-226
EI 
J9 J Cancer Surviv
PD FEB 6
PY 2017
VL 11
IS 4
BP 421
EP 430
DI 10.1007/s11764-017-0599-y 
PG 9
WC Adolescent; Adult; Aged; Aged, 80 and over; Complementary Therapies; methods; Female; France; Humans; Male; Middle Aged; Neoplasms; therapy; Quality of Life; Self Report; Surveys and Questionnaires; Survivors; psychology; Time Factors; Young Adult
UT PubMed:28150122
PM 28150122
DA 2017-02-06
ER

PT J
AU Hou, Y
   Lu, J
   Xie, J
   Zhu, R
   Wu, M
   Wang, K
   Zhou, J
   Li, J
AF Hou, Yuchao
   Lu, Jiajing
   Xie, Jing
   Zhu, Runjia
   Wu, Mengdie
   Wang, Ke
   Zhou, Jia
   Li, Jing
TI Effects of electroacupuncture on perioperative anxiety and stress response in 
SO Frontiers in psychiatry
LA English
DT Journal Article
DE electroacupuncture; perioperative anxiety; randomized controlled clinical trial (RCT); stress response; surgery
AB BACKGROUND: Perioperative anxiety is one of the main psychological stresses 
   experienced by patients who undergo cancer surgery. The surgery itself inevitably 
   causes a stress response characterized by activation of the sympathetic nervous 
   system and the hypothalamic-pituitary-adrenal axis. Both the perioperative 
   anxiety and surgical stress response lead to increased levels of catecholamines 
   and prostaglandins, which may be related to perioperative suppression of 
   antimetastatic immunity and tumor-promoting alterations in the microenvironment. 
   Hence, we designed this clinical trial to investigate the effect of 
   electroacupuncture in reducing perioperative anxiety and surgical stress 
   response. METHODS: This is a randomized, single-center, parallel, and controlled 
   clinical trial. Seventy-eight participants between the ages of 35 and 85 with 
   gastric or colorectal cancer who plan to undergo tumorectomy will be randomly 
   divided into an electroacupuncture group and a control group. The primary outcome 
   will be the six-item short form of the State-Trait Anxiety Inventory score. The 
   secondary outcomes will be the Amsterdam Preoperative Anxiety and Information 
   Scale score; levels of plasma cortisol, adrenocorticotropic hormone, 
   interleukin-6, and tumor necrosis factor-α; first exhaust time after surgery; 
   postoperative quality of the recovery-15 score, numeric rating scale for pain 
   score; and dosage of postoperative analgesics. DISCUSSION: Cumulative studies 
   revealed the efficacy of various types of acupuncture therapy with regard to 
   reducing the anxiety and stress response caused by surgery. We expect that the 
   results of this trial will provide high-quality clinical evidence for the choice 
   of perioperative acupuncture for patients undergoing cancer surgery. CLINICAL 
   TRIAL REGISTRATION: https://www.chictr.org.cn, identifier ChiCTR200003 7127.
C1 Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
NR 0
TC 0
SN 1664-064
EI 1664-064
J9 Front Psychiatry
PD MAR 14
PY 2023
VL 14
IS 
BP 1095650
EP 1095650
DI 10.3389/fpsyt.2023.1095650 
PG 0
UT PubMed:36911113
PM 36911113
DA 2023-03-14
ER

PT J
AU Cho, E
   Park, CH
   Cho, SY
AF Cho, Eunae
   Park, Chang-Hwan
   Cho, Seo Yeon
TI Single balloon enteroscopy-guided endoscopic retrograde pancreatography for the 
SO Medicine
LA English
DT Journal Article
AB RATIONALE: Endoscopic treatment of a pancreatic pseudocyst complicated by 
   pancreaticojejunostomy (PJ) stricture is challenging. PATIENT CONCERNS: A 
   76-year-old woman presented with worsening abdominal pain and dyspepsia. She had 
   been receiving adjuvant chemotherapy (capecitabine and cisplatin) for 4 months 
   after pylorus-preserving pancreaticoduodenectomy (PPPD) for the treatment of 
   extrahepatic cholangiocarcinoma. DIAGNOSES: Laboratory findings included elevated 
   serum amylase (145 U/L) and lipase (437 U/L) levels. Abdominal computed 
   tomography (CT) showed a pancreatic pseudocyst of approximately 3 cm in size and 
   pancreatic duct dilatation in the remnant pancreas. According to the Response 
   Evaluation Criteria in Solid Tumors, cholangiocarcinoma is a stable disease. 
   INTERVENTIONS AND OUTCOMES: Endoscopic drainage of the pancreatic pseudocyst was 
   planned. Single-balloon enteroscopy (SBE)-guided endoscopic retrograde 
   pancreatography (ERP) with endoscopic ultrasonography (EUS) using a mini probe 
   demonstrated a membranous PJ stricture and a pancreatic pseudocyst. Endoscopic 
   pseudocyst drainage using a 7-Fr plastic stent was successfully performed after 
   needle-knife incision of the PJ stricture. Follow-up abdominal CT after 3 weeks 
   showed complete resolution of the pseudocyst. Chemotherapy was resumed. LESSONS: 
   SBE-guided ERP with EUS using a mini probe may be an effective and safe treatment 
   in a patient with a pancreatic pseudocyst complicated by membranous PJ stricture 
   after PPPD.
C1 Division of Gastroenterology, Department of Internal Medicine, Chonnam National University School of Medicine, Gwangju, South Korea.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD NOV 2
PY 2022
VL 101
IS 43
BP e31293
EP e31293
DI 10.1097/MD.0000000000031293 
PG 1
WC Female; Humans; Aged; Pancreatic Pseudocyst; complications; Pancreaticojejunostomy; adverse effects; Single-Balloon Enteroscopy; Constriction, Pathologic; surgery; Pancreas; Endosonography; adverse effects; Drainage; methods; Treatment Outcome
UT PubMed:36316922
PM 36316922
DA 2022-11-02
ER

PT J
AU Samuels, N
   Ben-Arye, E
AF Samuels, Noah
   Ben-Arye, Eran
TI Integrative Medicine for Cancer-Related Pain: A Narrative Review.
SO Healthcare (Basel, Switzerland)
LA English
DT Review
DE acupuncture; cancer-related pain; complementary integrative medicine; herbal supplements; mind-body-medicine; pragmatic research; touch therapies
AB Cancer-related pain (C-RP) is a prevalent and debilitating concern among patients 
   with cancer, with conventional treatments limited in their ability to provide 
   adequate relief, and by the adverse effects associated with their use. 
   Complementary and integrative medicine (CIM) modalities have been shown to be 
   potentially effective and safe for the treatment of pain and related symptoms, 
   when used in conjunction with conventional medications and under medical 
   supervision. An increasing number of oncology centers provide CIM within their 
   conventional supportive and palliative care service, in an "Integrative Oncology" 
   (IO) setting. A large body of clinical research, including systematic reviews and 
   guidelines such as those published in 2022 by the Society for Integrative 
   Oncology (SIO), in collaboration with the American Society for Clinical Oncology 
   (ASCO), support the use of some CIM modalities for C-RP and related concerns. 
   These include acupuncture for general and peri-operative/procedural pain, as well 
   as aromatase inhibitor-associated arthralgia (AIA); reflexology or acupressure 
   for pain during systemic therapy for cancer; hypnosis for procedural pain or pain 
   due to diagnostic workup; and massage for pain experienced by patients during 
   palliative and hospice care. Further research is needed, within both randomized 
   control trials and pragmatic non-controlled studies which are more reflective of 
   the real-life IO setting. This review summarizes the evidence supporting the use 
   of CIM for C-RP; the analgesic mechanism of the modalities presented; and the 
   challenges facing IO researchers, as well as the implementation of the 2022 
   SIO-ASCO guideline recommendations.
C1 Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9103102, Israel.
   Integrative Oncology Program, The Oncology Service, Lin Carmel, and Zebulun Medical Centers, Clalit Health Services, Haifa 3535152, Israel.
   Department of Family Medicine, Faculty of Medicine, Technion-Israel Institute of 
NR 0
TC 0
SN 2227-903
EI 2227-903
J9 Healthcare (Basel)
PD FEB 10
PY 2024
VL 12
IS 3
BP 
EP 
DI 10.3390/healthcare12030403 
PG 0
UT PubMed:38338288
PM 38338288
DA 2024-02-10
ER

PT J
AU Zick, SM
   Sen, A
   Hassett, AL
   Schrepf, A
   Wyatt, GK
   Murphy, SL
   Arnedt, JT
   Harris, RE
AF Zick, Suzanna Maria
   Sen, Ananda
   Hassett, Afton Luevano
   Schrepf, Andrew
   Wyatt, Gwen Karilyn
   Murphy, Susan Lynn
   Arnedt, John Todd
   Harris, Richard Edmund
TI Impact of Self-Acupressure on Co-Occurring Symptoms in Cancer Survivors.
SO JNCI cancer spectrum
LA English
DT Journal Article
AB BACKGROUND: Cancer survivors with fatigue often experience depressive symptoms, 
   anxiety, and pain. Previously, we reported that self-acupressure improved 
   fatigue; however, its impact on other co-occurring symptoms and their involvement 
   in treatment action has not been explored. METHODS: Changes in depressive 
   symptoms, anxiety, and pain were examined prior to and following two formulas of 
   self-acupressure and usual care using linear mixed models in 288 women from a 
   previously reported clinical trial. Participants were categorized by random 
   assignment into one of three groups: 1) relaxing acupressure, 2) stimulating 
   acupressure, or 3) usual care. Moderators investigated were body mass index, age, 
   depressive symptoms, anxiety, sleep and pain, and mediators were change in these 
   symptoms. RESULTS: Following treatment, depressive symptoms improved 
   statistically significantly for the relaxing acupressure group (41.5%) compared 
   with stimulating acupressure (25%) and usual care (7.7%). Both acupressure groups 
   were associated with greater improvements in anxiety than usual care, but only 
   relaxing acupressure was associated with greater reductions in pain severity, and 
   only stimulating acupressure was associated with greater reductions in pain 
   interference. There were no statistically significant moderators of sleep 
   quality, anxiety, or depressive symptoms. Fatigue statistically significantly 
   moderated pain, and age statistically significantly modified fatigue. Changes in 
   depressive symptoms and sleep quality statistically significantly mediated the 
   relationship between relaxing acupressure and usual care on fatigue; however, the 
   effect was small. CONCLUSIONS: Acupressure was associated with greater 
   improvements than usual care in anxiety, pain, and symptoms of depression in 
   breast cancer survivors with troublesome fatigue. These findings warrant further 
   evaluation in suitably controlled randomized trials.
C1 Department of Family Medicine.
   Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI.
   Department of Family Medicine.
   Department of Biostatistics, University of Michigan, Ann Arbor, MI.
   Department of Anesthesiology, University of Michigan, Ann Arbor, MI.
   Department of Anesthesiology, University of Michigan, Ann Arbor, MI.
   College of Nursing, Michigan State University, East Lansing, MI.
   Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI.
   Physical Medicine and Rehabilitation, VA Ann Arbor Health Care System, GRECC, Ann 
   Sleep and Circadian Research Laboratory.
   Departments of Psychiatry and Neurology, University of Michigan, Ann Arbor, MI.
   Department of Anesthesiology, University of Michigan, Ann Arbor, MI.
NR 0
TC 0
SN 2515-509
EI 
J9 JNCI Cancer Spectr
PD JAN 29
PY 2019
VL 2
IS 4
BP pky064
EP pky064
DI 10.1093/jncics/pky064 
PG 1
UT PubMed:30687806
PM 30687806
DA 2019-01-29
ER

PT J
AU Chiaramonte, R
   Bonfiglio, M
   Caramma, S
   Condorelli, R
AF Chiaramonte, Rita
   Bonfiglio, Marco
   Caramma, Salvatore
   Condorelli, Rosaria
TI The Role of Rehabilitation in the Treatment of Constipation in Oncological 
SO Journal of clinical medicine
LA English
DT Review
DE constipation; neoplasms; osteopathy; rehabilitation
AB BACKGROUND: Chemotherapy, as well as opioid and antiemetic drugs, can contribute 
   to constipation in oncological patients. This systematic review aims to analyse 
   the potential of specific rehabilitation strategies and alternative strategies 
   for improving constipation symptoms, with the goal of incorporating these 
   strategies into a dedicated protocol for managing cancer-related constipation. 
   This could potentially reduce the dosages of or eliminate the need for 
   constipation medications. METHODS: A systematic search was conducted on PubMed, 
   Scopus and Web of Science. The review included studies analysing constipation 
   complaints in cancer patients treated with rehabilitation, acupuncture and 
   osteopathy. RESULTS: The review included 16 studies in line with PRISMA and PICOS 
   criteria. Most studies showed that physical exercise, abdominal massage, TENS, 
   acupuncture and education on the correct defecation position positively impacted 
   the management of constipation and quality of life in oncological patients. A 
   physiotherapy program involving massages as well as aerobic and resistance 
   training improved constipation in oncological women, regardless of age, sex and 
   frailty. A combination of abdominal massage, abdominal muscle stretching and 
   education on proper defecation position alleviated the severity of constipation 
   and related depression. However, the outcomes regarding TENS were yet 
   inconsistent. Another technique, becoming increasingly common for constipation, 
   and demonstrating positive results, involved stimulating trigger points through 
   acupressure and acupuncture. Conversely, osteopathic and superficial 
   manipulations more frequently required constipation medications than did the 
   other alternative approaches. However, no existing studies have proposed a 
   specific protocol to manage cancer-related constipation. CONCLUSIONS: The results 
   of the studies confirm the positive influences of rehabilitation, osteopathy and 
   acupuncture on constipation and pain in oncological patients. Nevertheless, 
   further studies are required to establish the best type, timing and duration of 
   treatment, as well as how the stage and location of the cancer and the cause of 
   constipation (drug-induced or functional) impact the results.
C1 Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
   Provincial Health Department of Siracusa, 96014 Sicily, Italy.
   Department of Pain Management, Policlinico-San Marco Hospital, 95123 Catania, Italy.
   Department of Medical Oncology, EOC-Istituto Oncologico della Svizzera Italiana, 6500 Bellinzona, Switzerland.
NR 0
TC 0
SN 2077-038
EI 2077-038
J9 J Clin Med
PD AUG 12
PY 2023
VL 12
IS 15
BP 
EP 
DI 10.3390/jcm12155083 
PG 0
UT PubMed:37568485
PM 37568485
DA 2023-08-12
ER

PT J
AU Zhang, J
   Liu, L
   Zhu, M
   Zheng, X
   Liang, Y
   Zhong, Y
   Xu, J
   Yang, J
AF Zhang, Jingwen
   Liu, Liying
   Zhu, Manjia
   Zheng, Xiaoyan
   Liang, Yun
   Zhong, Ying
   Xu, Jing
   Yang, Jie
TI Research Status and Prospects of Acupuncture in Perioperative Medicine Over the 
SO Journal of pain research
LA English
DT Review
DE CiteSpace; VOSviewer; acupuncture; mid-operative; perioperative medicine; post-operative
AB BACKGROUND: Over the past decade, acupuncture in the perioperative period has 
   attracted great interest, and a growing number of related literature has been 
   published. PURPOSE: To analyze the general information and identify the research 
   hotspots and trends of acupuncture in perioperative medicine in the last 10 years 
   by bibliometric analysis. METHODS: We searched the Web of Science Core Collection 
   for publications on acupuncture in perioperative medicine from 2013 to 2023. The 
   articles and reviews were collected with no language restriction. CiteSpace and 
   VOSviewer software were used for bibliometric and visual analysis of relevant 
   literature. RESULTS: A total of 814 bibliographic records were retrieved. 
   Overall, the annual number of publications showed an increasing trend. China and 
   its institutions were in a leading position regarding the publication number. 
   With comparatively more scientific collaboration with China, the USA ranked 
   second. Shanghai University of Traditional Chinese Medicine was the most prolific 
   institution. Ha, In-Hyuk had the most publications, and Han JS and Lee A were the 
   most cited authors. Medicine was the most popular journal and Journal of Clinical 
   Oncology had the highest impact factor. "Acupuncture", "electroacupuncture" and 
   "postoperative pain" were the top three keywords. The most popular topics were 
   postoperative pain, postoperative ileus, and postoperative nausea and vomiting 
   according to the keywords and references. And the clusters of postoperative 
   cognitive dysfunction, anxiety, and breast cancer attracted relatively more 
   attention recently. CONCLUSION: This study summarized the research status, 
   hotspots, and trends of acupuncture in perioperative medicine in the past decade, 
   which may aid researchers in better understanding this field. The research 
   hotspots primarily focused on postoperative pain management and postoperative 
   gastrointestinal function. The research of acupuncture for postoperative 
   cognitive dysfunction, cancer-related surgery, and psychological states were the 
   main frontiers topics and may be the focus in the future.
C1 Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
   Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
   Sichuan Jinxin Xi'nan Women's and Children's Hospital, Chengdu, Sichuan, People's 
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
   Sichuan Jinxin Xi'nan Women's and Children's Hospital, Chengdu, Sichuan, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
   Sichuan Jinxin Xi'nan Women's and Children's Hospital, Chengdu, Sichuan, People's 
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD JUL 3
PY 2023
VL 16
IS 
BP 2189
EP 2204
DI 10.2147/JPR.S415998 
PG 15
UT PubMed:37397275
PM 37397275
DA 2023-07-03
ER

PT J
AU Wang, W
   Wang, X
   Liu, Y
   Sun, Y
   Liu, X
   Yan, Y
   Liu, Z
AF Wang, Weiming
   Wang, Xinlu
   Liu, Yan
   Sun, Yuanjie
   Liu, Xiaoxu
   Yan, Yan
   Liu, Zhishun
TI Effects of Electroacupuncture on Opioid-Induced Constipation in Patients With 
SO Frontiers in medicine
LA English
DT Journal Article
DE acupuncture; cancer patients; opioid-induced constipation; randomized controlled trial; spontaneous bowel movements
AB BACKGROUND: Opioid-induced constipation (OIC) is one of the most prevalent 
   adverse events associated with cancer patients who receive opioid analgesics for 
   moderate to severe pain. Acupuncture may be an effective treatment for OIC. We 
   designed this trial to assess the efficacy and safety of electroacupuncture for 
   OIC in cancer patients. METHODS: This is a multicenter, sham-controlled, 
   parallel-group, subject- and assessor-blinded randomized trial. A total of 100 
   cancer patients with OIC will be randomly assigned to either the 
   electroacupuncture group or the sham electroacupuncture group at a ratio of 1:1. 
   Patients in each group will receive a total of 24-session treatment over 8 weeks, 
   three sessions a week and 30 min each session. Thereafter, patients will be 
   followed up for another 8 weeks. The primary outcome will be the proportion of 
   responders, defined as a patient who has ≥3 spontaneous bowel movements (SBMs)/wk 
   and ≥ increase of 1 SBM from baseline simultaneously for at least 6 out of 8 
   weeks of the treatment period. The secondary outcomes will include the mean 
   weekly SBMs and complete spontaneous bowel movements, the mean Bristol Stool Form 
   Scale score for stool consistency, the mean score for straining of SBM, the total 
   and subscale scores of Patient Assessment of Constipation-Symptom questionnaires, 
   and the total and subscale scores of Patient Assessment of Constipation-Quality 
   of Life questionnaire. Patients' global assessment of treatment effectiveness, 
   patients' expectation toward the effectiveness of acupuncture and safety of 
   acupuncture will also be assessed. All efficacy analyses will be performed in the 
   intention-to-treat population. DISCUSSION: To improve the adherence to 
   intervention protocols, the majority of the participants will be recruited from 
   an inpatient setting. The results will help to determine the clinical effects and 
   safety of electroacupuncture for the treatment of OIC among patients with cancer. 
   CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov, identifier: NCT03797586, 
   registered on 4 January 2019, https://clinicaltrials.gov/ct2/show/NCT03797586.
C1 Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
   Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
   Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
   Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
   Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
   Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
NR 0
TC 0
SN 2296-858
EI 2296-858
J9 Front Med (Lausanne)
PD MAY 3
PY 2022
VL 9
IS 
BP 818258
EP 818258
DI 10.3389/fmed.2022.818258 
PG 0
UT PubMed:35492306
PM 35492306
DA 2022-05-03
ER

PT J
AU Jafari, M
   Shabani, F
   Fathollahi, MS
   Barghi, TS
   Peighambari, SB
   Zargaz, SEH
AF Jafari, Mahya
   Shabani, Fidan
   Fathollahi, Mahmood Sheikh
   Barghi, Tohid Seif
   Peighambari, Seyed Babak
   Zargaz, Seyyed Ebrahim Hosseini
TI Effect of Acupressure on Pain and Sleep Quality of Patients with Cancer after 
SO Iranian journal of nursing and midwifery research
LA English
DT Journal Article
DE Acupressure; neoplasms; pain; sleep quality; surgery
AB BACKGROUND: Pain and sleep disturbances are among the most common symptoms and 
   complications in cancer patients. This study aims to evaluate the effect of 
   acupressure at the LI4 and SP6 points on pain and sleep quality in cancer 
   patients after surgery. MATERIALS AND METHODS: In this single-blind randomized 
   clinical trial, cancer patients admitted to the intensive care unit at the Cancer 
   Institute of Imam Khomeini Hospital in Tehran, Iran in 2022, following surgery, 
   were divided into two equal groups of 39: an intervention group and a control 
   group. On the second and third days after surgery, in the morning and evening, 
   acupressure was applied bilaterally at the LI4 (hand) and SP6 (foot) points, in 
   the experimental group. In the control group, surface touch was applied to the 
   same points. Patients' pain was assessed using the visual analog scale of pain, 
   and sleep quality was measured using the Richard-Campbell Sleep Questionnaire. 
   Data were analyzed using the two-way repeated measures analysis of variance. 
   RESULTS: Statistical analysis showed that the interaction effect of group and 
   time was statistically significant (p < 0.001), indicating that pain reduction 
   was significantly greater in the experimental group compared to the control 
   patients. A paired t-test demonstrated a significant increase in sleep quality 
   after the acupressure intervention in the experimental group (p < 0.001), whereas 
   no significant change was observed in the control group (p = 0.124). CONCLUSIONS: 
   Acupressure was found to effectively reduce pain and improve sleep quality in 
   cancer patients after surgery.
C1 Cardiovascular Nursing Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
   Cardiovascular Nursing Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
   National Center for Health Insurance Research, Tehran, Iran.
   Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
   Department of Biomedical Engineering, Texas A and M University, Texas, USA.
   Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
NR 0
TC 0
SN 2228-550
EI 1735-906
J9 Iran J Nurs Midwifery Res
PD AUG 20
PY 2025
VL 30
IS 4
BP 531
EP 537
DI 10.4103/ijnmr.ijnmr_368_23 
PG 6
UT PubMed:40832492
PM 40832492
DA 2025-08-20
ER

PT J
AU Lin, M
   Li, X
   Liang, W
   Liu, J
   Guo, J
   Zheng, J
   Liu, X
AF Lin, Munan
   Li, Xihai
   Liang, Wenna
   Liu, Jianhua
   Guo, Jianhong
   Zheng, Jingxiong
   Liu, Xianxiang
TI Needle-knife therapy improves the clinical symptoms of knee osteoarthritis by 
SO Experimental and therapeutic medicine
LA English
DT Journal Article
DE acupuncture; knee joint; needle-knife therapy; osteoarthritis
AB Knee osteoarthritis (KOA) is a degenerative joint disease that occurs mainly in 
   the elderly population. However, there are currently no effective treatments for 
   treating this condition. In this study, the efficacy of needle-knife therapy, a 
   technique of traditional Chinese medicine that has been widely used to treat KOA 
   was investigated. Patients (n=170) with KOA were randomly divided for 
   needle-knife therapy (treatment group) and acupuncture therapy (control group). 
   Outcome evaluation included stiffness, pain, physiological function, overall 
   changes, total symptom score, clinical curative effects and the concentrations of 
   interleukin (IL)-1β, IL-6 and tumor necrosis factor-α (TNF-α) in the synovial 
   fluid. The trial was completed in 151 patients (233 knees) from a total of 170 
   patients (264 knees); the treatment group comprised 76 patients (117 knees) who 
   completed the trial and 9 patients (14 knees) who were removed from the study, 
   and the control group comprised 75 patients (116 knees) who completed the trial 
   and 10 patients (17 knees) who were removed from the study. The symptom scores of 
   KOA in stages I-IV were reduced significantly in the treatment group and those of 
   stages I-III were decreased significantly in the control group. The effective 
   rate of the KOA therapy in the patients of stages III and IV in the treatment 
   group was significantly higher than that in the control group. After treatment, 
   the decrements of IL-1β, IL-6 and TNF-α in the treatment group were greater than 
   those in the control group. These results showed that the use of needle-knife 
   therapy to treat KOA effectively improved the clinical symptoms by inhibiting the 
   expression of inflammatory cytokines.
C1 Department of Traditional Chinese Medicine, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian 350025, P.R. China.
   Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, P.R. China.
   Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
   Department of Traditional Chinese Medicine, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian 350025, P.R. China.
   Department of Traditional Chinese Medicine, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian 350025, P.R. China.
   Department of Traditional Chinese Medicine, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian 350025, P.R. China.
   Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, P.R. China.
NR 0
TC 0
SN 1792-101
EI 1792-098
J9 Exp Ther Med
PD MAR 29
PY 2014
VL 7
IS 4
BP 835
EP 842
DI 10.3892/etm.2014.1516 
PG 7
UT PubMed:24669238
PM 24669238
DA 2014-03-29
ER

PT J
AU Yang, W
   Zhang, Y
   Yang, G
   Geng, Y
   Chen, D
   Wang, J
   Ye, Y
   Wang, H
   Xia, D
   Hu, F
   Jiang, J
   Xu, X
AF Yang, Wei
   Zhang, Yeke
   Yang, Gaoyi
   Geng, Yanhua
   Chen, Da
   Wang, Jun
   Ye, Yang
   Wang, Huaichong
   Xia, Dajing
   Hu, Fuliang
   Jiang, Jing
   Xu, Xiaofeng
TI Anti-PD-1 Immunotherapy and Bee Venom for Relapsed and Refractory Liposarcoma: A 
SO Frontiers in oncology
LA English
DT Journal Article
DE PD-1 inhibitor; STING pathway; apitherapy; bee venom; complementary medicine; immunotherapy; innate immunity; liposarcoma
AB Cancer immunotherapies, including immune checkpoint inhibitors, elicit long-term 
   clinical responses but many cancer patients do not respond. Intensive efforts are 
   therefore underway to identify additional immune pathways that may be modulated 
   to enhance the efficacy of existing immunotherapies. Bee venom strongly 
   stimulates the immune system, and is used as a complementary therapy to treat 
   cancer pain in patients with advanced tumors in China. Bee venom contains several 
   allergenic protease inhibitors and peptides. It triggers hypersensitivity 
   reactions; that is, it is an immune system agonist. The generation of a 
   spontaneous T cell response against tumor-associated antigens requires innate 
   immune activation; this drives type I interferon production. We report a patient 
   with a relapsed and refractory liposarcoma who had undergone several operations, 
   chemotherapies, and radiotherapies. The tumor was large. The patient had attained 
   the maximum radiation exposure dose. The tumor was resistant to chemotherapy and 
   was infiltrating the pericardium, lungs, and diaphragm. The patient was a poor 
   candidate for resection. He thus received apitherapy (a combination of bee venom 
   and acupuncture) to control pain; then apatinib (an anti-angiogenic drug) was 
   given to inhibit tumor growth but was terminated early because the patient could 
   not tolerate the side effects. Subsequently, a programmed death 1 inhibitor was 
   combined with apitherapy. Bee venom served as an innate immune system agonist 
   promoting immune cell priming and recruitment in the tumor microenvironment. The 
   patient was finally able to undergo radical liposarcoma resection, and no 
   evidence of recurrence was found at re-examination 16 months after surgery.
C1 Department of Oncology, Hangzhou Red Cross Hospital, Hangzhou, China.
   Department of Oncology, Hangzhou Red Cross Hospital, Hangzhou, China.
   Department of Medical Imaging, Hangzhou Red Cross Hospital, Hangzhou, China.
   Department of Pathology, Hangzhou Red Cross Hospital, Hangzhou, China.
   Department of Thoracic Surgery, Hangzhou Red Cross Hospital, Hangzhou, China.
   Department of Traditional Chinese Medicine, Hangzhou Red Cross Hospital, Hangzhou, China.
   Department of Traditional Chinese Medicine, Hangzhou Red Cross Hospital, Hangzhou, China.
   Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou, China.
   Department of Toxicology of School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
   College of Animal Sciences, Zhejiang University, Hangzhou, China.
   Department of Oncology, Hangzhou Red Cross Hospital, Hangzhou, China.
   Department of Oncology, Hangzhou Red Cross Hospital, Hangzhou, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD MAY 18
PY 2021
VL 11
IS 
BP 668992
EP 668992
DI 10.3389/fonc.2021.668992 
PG 0
UT PubMed:33996596
PM 33996596
DA 2021-05-18
ER

PT J
AU Krajewski, A
   Lech, G
   Makiewicz, M
   Kluciński, A
   Wojtasik, M
   Kozieł, S
   Słodkowski, M
AF Krajewski, Andrzej
   Lech, Gustaw
   Makiewicz, Marcin
   Kluciński, Andrzej
   Wojtasik, Monika
   Kozieł, Sławomir
   Słodkowski, Maciej
TI Infeasibility of endoscopic transmural drainage due to pancreatic pseudocyst wall 
SO Polski przeglad chirurgiczny
LA English
DT Journal Article
DE calcifications in the pancreatic pseudocyst wall; endoscopic transmural drainage; postinflammatory pancreatic pseudocysts
AB Postinflammatory pancreatic pseudocysts are one of the most common complications 
   of acute pancreatitis. In most cases, pseudocysts self-absorb in the course of 
   treatment of pancreatitis. In some patients, pancreatic pseudocysts are 
   symptomatic and cause pain, problems with gastrointestinal transit, and other 
   complications. In such cases, drainage or resection should be performed. Among 
   the invasive methods, mini invasive procedures like endoscopic transmural 
   drainage through the wall of the stomach or duodenum play an important role. For 
   endoscopic transmural drainage, it is necessary that the cyst wall adheres to the 
   stomach or duodenum, making a visible impression. We present a very rare case of 
   infeasibility of endoscopic drainage of a postinflammatory pancreatic pseudocyst, 
   impressing the stomach, due to cyst wall calcifications. A 55-year-old man after 
   acute pancreatitis presented with a 1-year history of epigastric pain and was 
   admitted due to a postinflammatory pseudocyst in the body and tail of pancreas. 
   On admission, blood tests, including CA 19-9 and CEA, were normal. An ultrasound 
   examination revealed a 100-mm pseudocyst in the tail of pancreas, which was 
   confirmed on CT and EUS. Acoustic shadowing caused by cyst wall calcifications 
   made the cyst unavailable to ultrasound assessment and percutaneous drainage. 
   Gastroscopy revealed an impression on the stomach wall from the outside. The 
   patient was scheduled for endoscopic transmural drainage. After insufflation of 
   the stomach, a large mass protruding from the wall was observed. The stomach 
   mucosa was punctured with a cystotome needle knife, and the pancreatic cyst wall 
   was reached. Due to cyst wall calcifications, endoscopic drainage of the cyst was 
   unfeasible. Profuse submucosal bleeding at the puncture site was stopped by 
   placing clips. The patient was scheduled for open surgery, and distal 
   pancreatectomy with splenectomy was performed. The histopathological examination 
   confirmed the initial diagnosis of postinflammatory pancreatic pseudocyst. 
   Endoscopic transmural drainage is a highly effective procedure for treating 
   postinflammatory pancreatic pseudocysts. In some patents, especially with large 
   pseudocysts, pseudocysts with calcified walls, and cysts of primary origin, 
   resection should be performed.
C1 Warszawski Uniwersytet Medyczny Katedra i Klinika Chirurgii Ogólnej, Gastroenterologicznej i Onkologicznej.
   Warszawski Uniwersytet Medyczny Katedra i Klinika Chirurgii Ogólnej, Gastroenterologicznej i Onkologicznej.
   Warszawski Uniwersytet Medyczny Katedra i Klinika Chirurgii Ogólnej, Gastroenterologicznej i Onkologicznej.
   Warszawski Uniwersytet Medyczny Katedra i Klinika Chirurgii Ogólnej, Gastroenterologicznej i Onkologicznej.
   Warszawski Uniwersytet Medyczny Katedra i Klinika Chirurgii Ogólnej, Gastroenterologicznej i Onkologicznej.
   Warszawski Uniwersytet Medyczny Katedra i Klinika Chirurgii Ogólnej, Transplantacyjnej i Wątroby.
   Warszawski Uniwersytet Medyczny Katedra i Klinika Chirurgii Ogólnej, Gastroenterologicznej i Onkologicznej.
NR 0
TC 0
SN 2299-284
EI 
J9 Pol Przegl Chir
PD MAY 20
PY 2017
VL 89
IS 1
BP 63
EP 67
DI 10.5604/01.3001.0009.6006 
PG 4
WC Calcinosis; etiology; Drainage; methods; Endoscopy; methods; Endoscopy, Digestive System; methods; Humans; Male; Middle Aged; Pancreatic Pseudocyst; surgery; Treatment Outcome
UT PubMed:28522785
PM 28522785
DA 2017-05-20
ER

PT J
AU Murari, J
   Sharma, I
   Atwal, SA
   Sharma, A
   Bandyopadhyay, S
   Shalini, B
   Kumar, M
AF Murari, Jerish
   Sharma, Ish
   Atwal, Siddharth Arjun
   Sharma, Aparna
   Bandyopadhyay, Sukanta
   Shalini, B
   Kumar, Manish
TI Understanding Cancer-Related Pain: Pathophysiology, Classification, and Treatment 
SO Cureus
LA English
DT Review
DE artificial intelligence; cancer-related pain; mechanism-based treatment; precision oncology; translational pain research
AB Cancer-related pain (CRP) is a complex, multidimensional challenge in oncology 
   that undermines quality of life, psychological well-being, and treatment 
   adherence. This narrative, mechanism-informed review synthesizes pathophysiology, 
   classification systems, and multidisciplinary management strategies to provide 
   clinical insights and research priorities. It connects nociceptive, neuropathic, 
   and mixed pain mechanisms to practical interventions, emphasizing peripheral and 
   central sensitization in chronicity. Major frameworks, including the WHO 
   analgesic ladder, International Classification of Diseases, 11th Revision, 
   Edmonton Classification System for Cancer Pain, and European Pain Federation 
   standards, are appraised alongside assessment tools such as the Visual Analogue 
   Scale, Brief Pain Inventory, and Hospital Anxiety and Depression Scale, with 
   examples of their clinical application. Management is framed within a flexible, 
   mechanism-based, multimodal model that integrates pharmacologic, adjuvant, 
   interventional, and psychosocial approaches, delivered through coordinated, 
   multidisciplinary teams. Evidence for complementary modalities, such as 
   acupuncture and mindfulness-based stress reduction, remains preliminary and 
   heterogeneous, requiring further high-quality trials, whereas opioid-based 
   pharmacologic approaches and structured psychosocial interventions such as 
   cognitive behavioral therapy are supported by more robust, established evidence. 
   Similarly, innovations like AI-driven monitoring and pharmacogenomics hold 
   promise but are still in the early validation phase, underscoring the need to 
   distinguish between evolving and well-established domains of cancer pain 
   management. The principal actionable priorities are to adopt mechanism-based 
   classification, embed multidisciplinary collaboration, expand multimodal access 
   in low-resource settings, and rigorously validate emerging pharmacogenomic and 
   digital health innovations before widespread clinical integration.
C1 Department of General Medicine, Chettinad Hospital and Research Institute, Kelambakkam, IND.
   Department of Ayurvedic Pathology, Babe Ke Ayurvedic Medical College and Hospital, Daudhar, IND.
   Department of Emergency Medicine, Civil Hospital Malerkotla, Malerkotla, IND.
   Department of Ayurvedic Eye and Ear, Nose, and Throat (ENT), National Institute of Ayurveda, Jaipur, IND.
   Department of Biochemistry, Rama Medical College Hospital and Research Centre, Kanpur, IND.
   Department of Pediatric Medicine, National Institute of Siddha, The Tamil Nadu Dr. M.G.R. Medical University, Chennai, IND.
   Department of Microbiology, School of Science, YBN University, Ranchi, IND.
   Department of Cancer Biology, ESIC Medical College and Hospital, Ranchi, IND.
NR 0
TC 0
SN 2168-818
EI 2168-818
J9 Cureus
PD OCT 3
PY 2025
VL 17
IS 9
BP e91395
EP e91395
DI 10.7759/cureus.91395 
PG 1
UT PubMed:41040753
PM 41040753
DA 2025-10-03
ER

PT J
AU Reed, EN
   Landmann, J
   Oberoi, D
   Piedalue, KL
   Faris, P
   Carlson, LE
AF Reed, Erica Nicole
   Landmann, Jessa
   Oberoi, Devesh
   Piedalue, Katherine-Ann L
   Faris, Peter
   Carlson, Linda E
TI Group versus Individual Acupuncture (AP) for Cancer Pain: A Randomized 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB BACKGROUND: A service delivery model using group acupuncture (AP) may be more 
   cost-effective than individual AP in general, but there is little evidence to 
   assess whether group AP is a comparable treatment in terms of efficacy to 
   standard individual AP. The study aimed to compare the group to individual 
   delivery of 6-week AP among cancer patients with pain. METHODS: The study design 
   was a randomized noninferiority trial of the individual (gold standard treatment) 
   vs. group AP for cancer pain. The primary outcome was pain interference and 
   severity, measured through the Brief Pain Inventory (BPI). Secondary outcomes 
   included measures of mood, sleep, fatigue, and social support. Changes in 
   outcomes from pre- to postintervention were examined using linear mixed effects 
   modeling and noninferiority was inferred using a noninferiority margin, a 
   difference of change between the two arms and 95% CIs. Pain interference was 
   tested with a noninferiority margin of 1 on the BPI, while pain severity and 
   secondary outcomes were compared using conventional statistical methods. RESULTS: 
   The trial included 74 participants randomly allocated to group (35) or individual 
   (39) AP. The noninferiority hypothesis was supported for pain interference 
   [Ө - 1, Δ 1.03, 95% CI: 0.15-2.20] and severity [Ө - 0.81, Δ 0.52, 95% 
   CI:.33-1.38] as well as for mood [Ө - 7.52, Δ 9.86, 95% CI: 0.85-18.86], sleep 
   [Ө - 1.65, Δ 2.60, 95% CI: 0.33-4.88], fatigue [Ө 8.54, Δ - 15.57, 95% CI: 
   25.60-5.54], and social support [Ө.26, Δ - 0.15, 95% CI:  - 0.42-0.13], meaning 
   that group AP was not inferior to individual AP treatment. Both arms evidenced 
   statistically significant improvements across all symptoms before and after the 
   intervention. Effect sizes for the group vs. individual AP on outcomes of pain, 
   sleep, mood, and social support ranged from small to very large and were 
   consistently larger in the group condition. The total average cost-per-person for 
   group AP ($221.25) was almost half that of individual AP ($420). CONCLUSIONS: 
   This is the first study to examine the noninferiority of group AP with the gold 
   standard individual AP. Group AP was noninferior to individual AP for treating 
   cancer pain and was superior in many health outcomes. Group AP is more 
   cost-effective for alleviating cancer pain and should be considered for 
   implementation trials.
C1 Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
   Vive Integrative Health Group, 1889 45 Street NW, Calgary, AB, Canada.
   Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
   Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
   Department of Analytics, Alberta Health Services (AHS) and Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada.
   Division of Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD MAY 1
PY 2020
VL 2020
IS 
BP 7209548
EP 7209548
DI 10.1155/2020/7209548 
PG 0
UT PubMed:32351602
PM 32351602
DA 2020-05-01
ER

PT J
AU Mora, DC
   Kristoffersen, AE
   Overvåg, G
   Jong, MC
   Mentink, M
   Liu, J
   Stub, T
AF Mora, Dana C
   Kristoffersen, Agnete E
   Overvåg, Grete
   Jong, Miek C
   Mentink, Marit
   Liu, Jianping
   Stub, Trine
TI Safety of Complementary and Alternative Medicine (CAM) treatment among children 
SO Integrative cancer therapies
LA English
DT Journal Article
DE complementary and alternative medicine; observational studies; patient safety; qualitative studies; risk; systematic review
AB BACKGROUND: Complementary and Alternative Medicine (CAM) is widely used around 
   the world to treat adverse effects derived from cancer treatment among children 
   and young adults. Parents often seek CAM to restore and maintain the child's 
   physical and emotional condition during and after cancer treatment. OBJECTIVES: 
   The objectives of this review were (i) to identify literature that investigates 
   CAM use for treating adverse effects of conventional cancer treatment, (ii) to 
   investigate the safety of the included CAM modalities, and (iii) to evaluate the 
   quality of included studies. METHODS: Five scientific research databases were 
   used to identify observational, quasi-experimental, and qualitative studies from 
   January 1990 to May 2021. Included studies investigated the use of CAM to treat 
   adverse effects of cancer treatment in childhood cancer. RESULTS: Fifteen studies 
   were included in this review. Ten quasi-experimental, 3 observational studies 
   (longitudinal/prospective), 2 qualitative studies, and 1 study with a 
   quasi-experimental and qualitative arm were identified. Less than half (n = 6; 
   40%) of the studies included reported adverse effects for the CAM modality being 
   studied. Among the studies that reported adverse effects, they were mostly 
   considered as direct risk, as 13% reported mainly bleeding and bruising upon 
   acupuncture treatment, and dizziness with yoga treatment. All adverse effects 
   were assessed as minor and transient. CAM modalities identified for treating 
   adverse effects of cancer treatment were alternative medical systems, 
   manipulative and body-based therapies, biologically-based therapies, and 
   mind-body therapies. CAM modalities were used to alleviate anxiety, pain, 
   toxicity, prevent trauma, and improve health-related quality of life, functional 
   mobility, and physical activity levels. All studies assessed scored 70% or above 
   according to the Joanna Briggs Institute critical appraisal for study quality 
   checklists. CONCLUSION: Most of the studies (58.3%) included in this review did 
   not report adverse effects from CAM modalities used to treat adverse effects of 
   cancer treatment in children and young adults. This lack of safety information is 
   of concern because parents need to know whether the modality represents an extra 
   burden or harm to the child. To improve awareness about safety in the field, a 
   universal and uniform reporting system for adverse effects in CAM research is 
   needed.
C1 UiT The Arctic University of Norway, Tromsø, Norway.
   UiT The Arctic University of Norway, Tromsø, Norway.
   UiT The Arctic University of Norway, Tromsø, Norway.
   UiT The Arctic University of Norway, Tromsø, Norway.
   Netherlands Institute for Health Services Research, Utrecht, The Netherlands.
   Beijing University of Chinese Medicine and Pharmacology, Beijing, China.
   UiT The Arctic University of Norway, Tromsø, Norway.
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD JUN 22
PY 2022
VL 21
IS 
BP 15347354221105563
EP 15347354221105563
DI 10.1177/15347354221105563 
PG 1
WC Child; Complementary Therapies; adverse effects; Drug-Related Side Effects and Adverse Reactions; etiology; Humans; Mind-Body Therapies; Neoplasms; therapy; Prospective Studies; Quality of Life; Young Adult
UT PubMed:35726681
PM 35726681
DA 2022-06-22
ER

PT J
AU Gjeorgjievski, M
   Manickam, P
   Ghaith, G
   Cappell, MS
AF Gjeorgjievski, Mihajlo
   Manickam, Palaniappan
   Ghaith, Gehad
   Cappell, Mitchell S
TI Safety and Efficacy of Endoscopic Therapy for Nonmalignant Duodenal Duplication 
SO Medicine
LA English
DT Review
AB Analyze efficacy, safety of endoscopic therapy for duodenal duplication cysts 
   (DDC) by comprehensively reviewing case reports.Tandem, independent, systematic, 
   computerized, literature searches were performed via PubMed using medical subject 
   headings or Keywords "cyst" and "duodenal" and "duplication"; or "cyst", and 
   "endoscopy" or "endoscopic", and "therapy" or "decompression"; with 
   reconciliation of generated references by two experts. Case report followed CARE 
   guidelines.Literature review revealed 28 cases (mean = 1.3 ± 1.2 cases/report). 
   Endoscopic therapy is increasingly reported recently (1984-1999: 3 cases, 
   2000-2015: 25 cases, P = 0.003, OR = 8.33, 95%-CI: 1.77-44.5). Fourteen (54%) of 
   26 patients were men (unknown-sex = 2). Mean age = 32.2 ± 18.3 years old. 
   Procedure indications: acute pancreatitis-16, abdominal pain-8, jaundice-2, 
   gastrointestinal (GI) obstruction-1, asymptomatic cyst-1. Mean maximal DDC 
   dimension = 3.20 ± 1.53 cm (range, 1-6.5 cm). Endoscopic techniques included cyst 
   puncture via needle knife papillotomy (NKP)/papillotome-18, snare resection of 
   cyst-7, cystotome-2, and cyst needle aspiration/ligation-1. Endoscopic therapy 
   was successful in all cases. Among 24 initially symptomatic patients, all 
   remained asymptomatic post-therapy without relapses (mean follow-up = 36.5 ± 48.6 
   months, 3 others reported asymptomatic at follow-up of unknown duration; 1 
   initially asymptomatic patient remained asymptomatic 3 years post-therapy). Two 
   complications occurred: mild intraprocedural duodenal bleeding related to NKP and 
   treated locally endoscopically.A patient is reported who presented with vomiting, 
   15-kg-weight-loss, and profound dehydration for 1 month from extrinsic 
   compression of duodenum by 14 × 6 cm DDC, underwent successful endosonographic 
   cyst decompression with large fenestration of cyst and endoscopic aspiration of 
   1 L of fluid from cyst with rapid relief of symptoms. At endoscopy the DDC was 
   intubated and visualized and random endoscopic mucosal biopsies were obtained to 
   help exclude malignant or dysplastic DDC.Study limitations include retrospective 
   literature review, potential reporting bias, limited patient number, variable 
   follow-up.In conclusion, endoscopic therapy for DDC was efficacious in all 29 
   reported patients including current case, including patients presenting acutely 
   with acute pancreatitis, or GI obstruction. Complications were rare and minor, 
   suggesting that endoscopic therapy may be a useful alternative to surgery for 
   nonmalignant DDC when performed by expert endoscopists.
C1 From the Division of Gastroenterology & Hepatology, William Beaumont Hospital (MG, PM, GG, MSC)
   and Oakland University William Beaumont School of Medicine(GG, MSC), Royal Oak, MI.
NR 0
TC 0
SN 1536-596
EI 0025-797
J9 Medicine (Baltimore)
PD JUN 4
PY 2016
VL 95
IS 22
BP e3799
EP e3799
DI 10.1097/MD.0000000000003799 
PG 1
WC Adult; Cysts; diagnosis; Duodenal Diseases; diagnosis; Endoscopy; methods; Humans; Male
UT PubMed:27258515
PM 27258515
DA 2016-06-04
ER

PT J
AU Kasymjanova, G
   Grossman, M
   Tran, T
   Jagoe, RT
   Cohen, V
   Pepe, C
   Small, D
   Agulnik, J
AF Kasymjanova, G
   Grossman, M
   Tran, T
   Jagoe, R T
   Cohen, V
   Pepe, C
   Small, D
   Agulnik, J
TI The potential role for acupuncture in treating symptoms in patients with lung 
SO Current oncology (Toronto, Ont.)
LA English
DT Journal Article
DE Acupuncture; Edmonton Symptom Assessment System; esas; integrative oncology clinics; lung cancer; narcotics; pain
AB BACKGROUND: Most lung cancer patients experience multiple symptoms related either 
   to the disease or its treatment. The commonly reported symptoms are pain, 
   depression, anxiety, nausea, and poor well-being. The aim of the present study 
   was to evaluate the effect of acupuncture as a potential treatment modality in 
   symptomatic lung cancer patients. METHODS: This prospective observational study 
   enrolled 33 lung cancer patients from the Peter Brojde Lung Cancer Centre between 
   August 2010 and May 2012. All patients received 45-minute sessions of 
   acupuncture, 1-2 times weekly for a minimum of 4 sessions. Symptom severity was 
   assessed using the Edmonton Symptom Assessment System (esas) before and after 
   completion of acupuncture. RESULTS: The study cohort included 30 patients with 
   non-small- cell lung cancer and 3 with small-cell lung cancer. Mean age was 62 
   years (range: 36-88 years); 17 of the patients were women. Most of the patients 
   had advanced-stage cancer (73%) and good performance status (Eastern Cooperative 
   Oncology Group 0-1: 88%). Of these patients, 67% received anticancer treatment 
   (chemotherapy or radiotherapy, or both) with acupuncture. Of the remaining 10 
   patients, 8 received acupuncture after a complete surgical resection of their 
   tumour, and because of their advanced age, 2 received acupuncture and best 
   supportive care. The median number of acupuncture sessions was 7 (interquartile 
   range: 4-13 sessions). Statistically significant improvements in pain, appetite, 
   nausea, nervousness, and well-being were observed. A clinically important 
   improvement (2 points on the esas) was reported by 61% of patients for pain and 
   by 33% for well-being. A significant positive correlation between improved 
   well-being and the number of acupuncture sessions was observed. This correlation 
   remained significant even after controlling for treatment and narcotic use. 
   Receiver operating characteristic analysis demonstrated that a minimum of 6 
   acupuncture sessions are required for a 70% chance of a clinically important 
   improvement in well-being. CONCLUSIONS: The present study is the first to 
   demonstrate that acupuncture may be an effective approach for improving 
   symptoms-in particular, pain and well-being-in lung cancer patients. Acupuncture 
   is a safe and minimally invasive procedure, and it is potentially useful even in 
   patients undergoing anticancer treatment.
C1 Peter Brojde Lung Cancer Centre, Montreal, QC. 
   Jewish General Hospital, Montreal, QC.
NR 0
TC 0
SN 1718-772
EI 1198-005
J9 Curr Oncol
PD JUN 6
PY 2013
VL 20
IS 3
BP 152
EP 7
DI 10.3747/co.20.1312 
PG -145
UT PubMed:23737683
PM 23737683
DA 2013-06-06
ER

PT J
AU Shushtari, SSG
   Kennedy, AB
   Jahangiri, M
   White, SJ
   Miladinia, M
   Karimpourian, H
AF Shushtari, Sima Sadat Ghaemizade
   Kennedy, Ann Blaire
   Jahangiri, Mina
   White, Sharon Jackson
   Miladinia, Mojtaba
   Karimpourian, Hossein
TI Comparing Massage, Acupressure, and Combined Therapy for Managing Cancer-related 
SO International journal of therapeutic massage & bodywork
LA English
DT Journal Article
DE Complementary medicine; oncology; palliative medicine; supportive care; symptom management
AB BACKGROUND: Massage and acupressure are highly popular among cancer patients as 
   non-invasive methods with different mechanisms that can target multiple 
   coexisting symptoms. However, the comparative effectiveness between these two 
   techniques is still unclear, particularly among patients with advanced cancer. 
   Furthermore, it is unclear whether both approaches would have a synergistic 
   effect if applied simultaneously. The main objective is to compare the efficacy 
   of massage alone versus acupressure alone versus combined therapy (massage plus 
   acupressure) for managing cancer-related symptom cluster of fatigue, pain, and 
   sleep disturbance. METHODS: The 2-FAM-2 study is a four-arm, longitudinal, 
   randomized trial comparing the efficacy of two complementary medicine techniques 
   (massage alone vs. acupressure alone vs. combined therapy vs. control) for 
   managing a fatigue-pain-sleep symptom cluster in patients with advanced cancer 
   that will use a 2 × 2 factorial design with an equal allocation ratio. One 
   hundred adult patients with advanced cancer who have all three symptoms of pain, 
   fatigue, and sleep disturbance will be recruited. Four weeks of intervention and 
   4 weeks of follow-up with repeated measures will be part of the 8-week study 
   period. The main outcome is the longitudinal trajectory (trend) in the intensity 
   of the pain-sleep-fatigue symptom cluster over time, assessed via generalized 
   estimating equations (GEE) at baseline, weekly during intervention (weeks 1-4), 
   and at weeks 6 and 8 as follow-up. Self-reported fatigue, sleep disturbance, and 
   pain items (0-10 scale) will be averaged to compute the symptom cluster intensity 
   (SCI). Furthermore, a machine learning technique based on decision tree 
   algorithms will be carried out to conduct a subgroup analysis aimed at predicting 
   clinical outcomes for different interventions in homogeneous subgroups. 
   DISCUSSION: The trial's findings could be helpful in the development of clinical 
   guidelines, individualization of intervention, as well as guiding clinical 
   decisions and improving the quality of life of patients.
C1 Nursing Care Research Center in Chronic Diseases, School of Nursing, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
   Department of Biomedical Sciences, School of Medicine Greenville, University of South Carolina, Greenville, SC, USA.
   Department of Family Medicine, Prisma Health, Greenville, SC, USA.
   Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
   Emory University, Nell Hodgson Woodruff School of Nursing, Atlanta, GA, USA.
   Nursing Care Research Center in Chronic Diseases, School of Nursing, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
   Department of Medical Oncology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
NR 0
TC 0
SN 1916-257
EI 1916-257
J9 Int J Ther Massage Bodywork
PD DEC 8
PY 2025
VL 18
IS 4
BP 31
EP 44
DI 10.3822/ijtmb.v18i4.1269 
PG 13
UT PubMed:41356775
PM 41356775
DA 2025-12-08
ER

PT J
AU de, Valois B
   Asprey, A
   Young, T
AF de Valois, Beverley
   Asprey, Anthea
   Young, Teresa
TI "The Monkey on Your Shoulder": A Qualitative Study of Lymphoedema Patients' 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB Background. Lymphoedema, a distressing consequence of cancer treatment, has 
   significant negative impact on health-related quality of life. Multidisciplinary 
   approaches are needed to improve physical and psychosocial wellbeing. Acupuncture 
   and moxibustion (acu/moxa), two modalities of traditional East Asian medicine, 
   may contribute to improved outcomes for cancer survivors with lymphoedema. Aim. 
   To explore how patients with lymphoedema secondary to cancer treatment perceive 
   and experience acu/moxa treatment. Design and Setting. A qualitative focus group 
   study, nested in a 3-step mixed methods observational study, was carried out in a 
   cancer drop-in and information centre in north-west London. Methods. Six focus 
   groups and one telephone interview were conducted with 23 survivors of breast or 
   head and neck cancer, who had completed up to 13 acu/moxa treatments. Scripts 
   were transcribed, coded, and analysed to identify salient and overarching themes. 
   Results. Participants described feeling disempowered by cancer treatment and 
   subsequent diagnosis of lymphoedema. Acu/moxa was valued for its whole-person 
   approach and for time spent with a practitioner who cared, listened, and 
   responded. Participants reported changes in physical and psychosocial health, 
   including increased energy levels and reduced pain and discomfort, and feelings 
   of empowerment, personal control, and acceptance. Many were motivated to improve 
   self-care. Conclusion. Many participants who received acu/moxa treatment reported 
   improved wellbeing and a more proactive attitude towards self-care.
C1 Supportive Oncology Research Team, Lynda Jackson Macmillan Centre, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex HA6 2RN, UK.
   University of Exeter Medical School, Magdalen Road, Exeter EX1 2LU, UK.
   Supportive Oncology Research Team, Lynda Jackson Macmillan Centre, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex HA6 2RN, UK.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD SEP 16
PY 2016
VL 2016
IS 
BP 4298420
EP 4298420
DI 10.1155/2016/4298420 
PG 0
UT PubMed:27630734
PM 27630734
DA 2016-09-16
ER

PT J
AU Shi, J
   Ren, X
   Tian, Q
   Sun, A
   Chen, R
AF Shi, Jinghua
   Ren, Xinyu
   Tian, Qinjie
   Sun, Aijun
   Chen, Rong
TI Persistent megalocystic ovaries after ovarian hyperstimulation syndrome in a 
SO Journal of ovarian research
LA English
DT Journal Article
DE Ovarian hyperstimulation syndrome; Ovarian torsion; Persistent megalocystic ovaries; Polycystic ovarian syndrome
AB BACKGROUND: Ovary enlargement is common in controlled ovarian stimulation, which 
   could continue several months during a successful pregnancy. However, persistent 
   megalocystic ovaries 3 years after ovarian hyperstimulation syndrome (OHSS) were 
   rare. Here we will present you the case and treatment as well as discuss the 
   probable etiology. CASE PRESENTATION: A 34-year-old woman with polycystic ovarian 
   syndrome (PCOS) and a history of infertility presented to the Department of 
   Obstetrics and Gynecology at Peking Union Medical College Hospital with abdominal 
   pain and persistently enlarged ovaries 36 months after OHSS. Enlarged ovaries 
   were evaluated with ultrasonography and serum tests. Diagnostic laparoscopic 
   surgery with detorsion and drainage followed by GnRHa treatment was performed. 
   Symptoms and ovarian size evaluated by vaginal ultrasound were the main outcome 
   measures. The patient was discharged from the hospital 5 days after surgery 
   without any remarkable complications. Both ovaries recovered to almost normal 
   after a monthly injection of GnRHa for 3 months. CONCLUSIONS: Ovarian enlargement 
   may persist for a long time in patients with severe OHSS even after sex hormone 
   levels and ovarian functions return to normal. Long term follow-up is necessary 
   and ovarian torsion should be suspected when accompanied by abdominal pain. 
   Acupuncture plus GnRHa treatment may be an effective way for these cases.
C1 Department of Obstetrics and Gynecology, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College, Chinese Academy of Medical Science,Beijing, 100730, People's Republic of China.
   Department of Pathology, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People'sRepublic of China.
   Department of Obstetrics and Gynecology, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College, Chinese Academy of Medical Science,Beijing, 100730, People's Republic of China.
   Department of Obstetrics and Gynecology, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College, Chinese Academy of Medical Science,Beijing, 100730, People's Republic of China.
   Department of Obstetrics and Gynecology, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College, Chinese Academy of Medical Science,Beijing, 100730, People's Republic of China. chenrongpumch@163.com.
NR 0
TC 0
SN 1757-221
EI 
J9 J Ovarian Res
PD SEP 12
PY 2018
VL 11
IS 1
BP 79
EP 79
DI 10.1186/s13048-018-0451-7 
PG 0
WC Adult; Female; Humans; Ovarian Hyperstimulation Syndrome; blood; Polycystic Ovary Syndrome; complications
UT PubMed:30201001
PM 30201001
DA 2018-09-12
ER

PT J
AU Franconi, G
   Manni, L
   Schröder, S
   Marchetti, P
   Robinson, N
AF Franconi, Giovanna
   Manni, Luigi
   Schröder, Sven
   Marchetti, Paolo
   Robinson, Nicola
TI A systematic review of experimental and clinical acupuncture in 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect that 
   can be very disabling and can limit or delay the dose of chemotherapy that can be 
   administered. Acupuncture may be effective for treating peripheral neuropathy. 
   The aim of this study was to review the available literature on the use of 
   acupuncture for CIPN. The systematic literature search was performed using 
   MEDLINE, Google Scholar, Cochrane Database, CINHAL, and ISI Proceedings. Hand 
   searching was conducted, and consensus was reached on all extracted data. Only 
   papers in the English language were included, irrespective of study design. From 
   3989 retrieved papers, 8 relevant papers were identified. One was an experimental 
   study which showed that electroacupuncture suppressed CIPN pain in rats. In 
   addition, there were 7 very heterogeneous clinical studies, 1 controlled 
   randomised study using auricular acupuncture, 2 randomized controlled studies 
   using somatic acupuncture, and 3 case series/case reports which suggested a 
   positive effect of acupuncture in CIPN. Conclusions. Only one controlled 
   randomised study demonstrated that acupuncture may be beneficial for CIPN. All 
   the clinical studies reviewed had important methodological limitations. Further 
   studies with robust methodology are needed to demonstrate the role of acupuncture 
   for treating CIPN resulting from cancer treatment.
C1 Department of Systems Medicine, Tor Vergata University, 00133 Rome, Italy.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD AUG 29
PY 2013
VL 2013
IS 
BP 516916
EP 516916
DI 10.1155/2013/516916 
PG 0
UT PubMed:23983788
PM 23983788
DA 2013-08-29
ER

PT J
AU Vella, R
   Giardino, A
   Pizzocaro, E
   Frigerio, I
   Bannone, E
   Vieni, S
   Butturini, G
AF Vella, Roberta
   Giardino, Alessandro
   Pizzocaro, Erica
   Frigerio, Isabella
   Bannone, Elisa
   Vieni, Salvatore
   Butturini, Giovanni
TI Unconventional Treatments for Pancreatic Cancer: A Systematic Review.
SO Cancers
LA English
DT Review
DE complementary medicine; pancreatic cancer; precision oncology; systematic review; unconventional treatment
AB OBJECTIVE: This study aims to review the existing literature on the efficacy and 
   safety of unconventional treatments among pancreatic cancer patients, including 
   the use of natural products, dietary supplements, probiotics, whole medical 
   systems, and body-based therapies. METHODS: An electronic, systematic, and 
   comprehensive literature review was conducted searching for studies up to 
   November 2024 following the PRISMA 2020 guidelines. Randomized controlled trials 
   and prospective and retrospective studies assessing the efficacy and safety of 
   unconventional treatments for pancreatic cancer were considered eligible. Data on 
   overall survival, quality of life, and treatment tolerability were extracted. 
   RESULTS: A total of 21 studies, providing data from 3095 patients, met the 
   inclusion criteria. Various types of unconventional treatments are used in 
   pancreatic cancer patients, including Chinese herbal medicine (CHM), mistletoe 
   extract (ME), curcumin, and electroacupuncture. Among these, the use of CHM and 
   curcumin concomitant with standard therapy was associated with survival and 
   quality-of-life benefits. Electroacupuncture reduced pancreatic cancer pain 
   intensity in a cost-effective manner. The data on ME are mixed and of 
   insufficient quality for drawing definitive conclusions. CONCLUSIONS: Some 
   unconventional treatments showed potential benefits in improving overall survival 
   and quality of life in pancreatic cancer patients within an integrative oncology 
   setting. Further high-quality studies are needed to provide robust, rigorous, and 
   ethical evidence to support their integration into future guidelines, ensuring a 
   holistic approach to cancer treatment.
C1 HPB Surgery, Pederzoli Hospital, Peschiera del Garda, 37019 Verona, Italy.
   Department of Precision Medicine in Medical, Surgical, and Critical Care, 
   HPB Surgery, Pederzoli Hospital, Peschiera del Garda, 37019 Verona, Italy.
   HPB Surgery, Pederzoli Hospital, Peschiera del Garda, 37019 Verona, Italy.
   PhD School of Applied Medical-Surgical Sciences, University Tor Vergata, 00133 
   HPB Surgery, Pederzoli Hospital, Peschiera del Garda, 37019 Verona, Italy.
   Collegium Medicum, SAN University, 90-012 Lodz, Poland.
   HPB Surgery, Pederzoli Hospital, Peschiera del Garda, 37019 Verona, Italy.
   Department of Precision Medicine in Medical, Surgical, and Critical Care, (Me.Pre.C.C.), University of Palermo, 90133 Palermo, Italy.
   HPB Surgery, Pederzoli Hospital, Peschiera del Garda, 37019 Verona, Italy.
NR 0
TC 0
SN 2072-669
EI 2072-669
J9 Cancers (Basel)
PD MAY 14
PY 2025
VL 17
IS 9
BP 
EP 
DI 10.3390/cancers17091437 
PG 0
UT PubMed:40361364
PM 40361364
DA 2025-05-14
ER

PT J
AU Bahçecioğlu, Turan G
   Özer, Z
   Yanmış, S
   Aksoy, A
AF Bahçecioğlu Turan, Gülcan
   Özer, Zülfünaz
   Yanmış, Safiye
   Aksoy, Asude
TI The Effects of Self-Acupressure on Pain, Fatigue, and Sleep Quality in Colon and 
SO Cancer nursing
LA English
DT Journal Article
AB BACKGROUND: Pancreatic and colon cancer are among important gastrointestinal 
   cancer diseases. Pain, fatigue, and insomnia are among the most common symptoms 
   in cancer patients receiving chemotherapy. Self-acupressure may improve patients' 
   pain, fatigue, sleep quality, quality of life, and functional well-being. 
   OBJECTIVE: The aim of this study was to examine the effects of self-acupressure 
   application on pain, fatigue, and sleep quality in colon and pancreatic cancer 
   patients receiving chemotherapy. METHODS: This randomized controlled study was 
   conducted with 60 patients in treatment for pancreatic or colon cancer, 30 in the 
   intervention and 30 in the control group, between June and October 2021. 
   Participants in the intervention group were asked to complete 16 acupressure 
   sessions for 4 weeks, 2 days a week in the morning and afternoon for a total of 
   18 minutes, depending on the preparation and pressure time on 4 pressure points. 
   Control group participants did not receive any interventions during the study. 
   The data were collected by using a personal information form, the Pittsburgh 
   Sleep Quality Index, the Piper Fatigue Scale, and the visual analog scale. 
   RESULTS: After self-acupressure, the visual analog scale, Piper Fatigue Scale, 
   and Pittsburgh Sleep Quality Index scores of the intervention group decreased 
   when compared with the control group scores; the difference between the 2 groups 
   was statistically significant. CONCLUSION: Self-acupressure was effective in 
   reducing the pain, fatigue, and sleep disorder scores of patients with colon or 
   pancreatic cancer receiving chemotherapy. IMPLICATIONS FOR PRACTICE: In nursing 
   practice, self-acupressure, an applicable, accessible, and inexpensive method in 
   the management of cancer-related symptoms, can be supported and maintained during 
   a 4-week period.
C1 Author Affiliations: Faculty of Health Sciences, Department of Nursing, Fırat University (Dr Bahçecioğlu Turan), Elaziğ
   Faculty of Health Sciences, IstanbulSabahattin Zaim University (Dr Özer)
   Faculty of Health Sciences, Department ofNursing, Erzican Binali Yıldırım University (Dr Yanmış)
   and Department ofInternal Medicine, Medical School Fırat University (Dr Aksoy), Elaziğ, Turkey.
NR 0
TC 0
SN 1538-980
EI 
J9 Cancer Nurs
PD FEB 3
PY 2023
VL 46
IS 6
BP 457
EP 466
DI 10.1097/NCC.0000000000001193 
PG 9
UT PubMed:36728147
PM 36728147
DA 2023-02-03
ER

PT J
AU Plaut, S
AF Plaut, Shiloh
TI Suggesting a mechanism for acupuncture as a global percutaneous needle fasciotomy 
SO Frontiers in medicine
LA English
DT Journal Article
DE acupuncture; fascial armoring; fibromyalgia; mechanism; myofibroblast; needling; pain; treatment
AB Acupuncture is a minimally invasive therapeutic method that uses small caliber 
   needles while inserting them through the skin into various areas of the body. 
   Some empirical studies find evidence to support the use of acupuncture as a 
   treatment for certain medical conditions, however, this peculiar practice is 
   widely considered as the domain of alternative and non-evidence-based medicine. 
   Several mechanisms have been suggested in an attempt to explain the therapeutic 
   action of acupuncture, but the way in which acupuncture alleviates chronic 
   non-cancer pain or psychosomatic and psychiatric disorders is not fully 
   understood. A recent study suggested a theoretical model (coined "Fascial 
   Armoring") with a cellular pathway to help explain the pathogenesis of myofascial 
   pain/fibromyalgia syndrome and functional psychosomatic syndromes. It proposes 
   that these syndromes are a spectrum of a single medical entity that involves 
   myofibroblasts with contractile activity in fascia and aberrant extracellular 
   matrix (ECM) remodeling, which may lead to widespread mechanical tension and 
   compression. This can help explain diverse psycho-somatic manifestations of 
   fibromyalgia-like syndromes. Fascia is a continuous interconnected tissue network 
   that extends throughout the body and has qualities of bio-tensegrity. Previous 
   studies show that a mechanical action by needling induces soft tissue changes and 
   lowers the shear modulus and stiffness in myofascial tissue. This hypothesis and 
   theory paper offers a new mechanism for acupuncture therapy as a global 
   percutaneous needle fasciotomy that respects tensegrity principles 
   (tensegrity-based needling), in light of the theoretical model of "Fascial 
   Armoring." The translation of this model to other medical conditions carries 
   potential to advance therapies. These days opioid overuse and over-prescription 
   are ubiquitous, as well as chronic pain and suffering.
C1 Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, Cyprus.
NR 0
TC 0
SN 2296-858
EI 2296-858
J9 Front Med (Lausanne)
PD FEB 14
PY 2023
VL 9
IS 
BP 952159
EP 952159
DI 10.3389/fmed.2022.952159 
PG 0
UT PubMed:36777160
PM 36777160
DA 2023-02-14
ER

PT J
AU Bloch, AS
   Bloch, PJ
   Dahmen, A
   Xu, R
   Sherman, Z
   Ledbetter, CK
   Wake, RW
   West, J
   Patterson, AL
AF Bloch, Aaron S
   Bloch, Paul J
   Dahmen, Aaron
   Xu, Raymond
   Sherman, Zachary
   Ledbetter, Christopher K
   Wake, Robert W
   West, Jim
   Patterson, Anthony L
TI Acupuncture for Analgesia During Transurethral Resection of Bladder Tumor.
SO Journal of endourology case reports
LA English
DT Journal Article
DE acupuncture; analgesia; bladder cancer; transurethral surgery
AB Background: Acupuncture has been widely studied, and theories regarding its 
   analgesic mechanism of action have been proposed. It has been used for procedural 
   analgesia; however, no reports of its use in urologic surgery have been reported. 
   In this case report, we demonstrate how acupuncture can be used as an alternative 
   to general anesthesia for transurethral resection of bladder tumor (TURBT). This 
   may serve as an attractive option for bladder cancer patients with medical 
   comorbidities, which predispose them to high risk for general anesthesia. Case 
   Presentation: A 65-year-old Caucasian female with toxicant-induced loss of 
   tolerance (TILT) was found to have a bladder mass. TURBT was discussed, and in 
   light of her TILT syndrome, she elected to undergo the procedure with acupuncture 
   in lieu of general anesthesia for fear of an adverse reaction. Acupuncture was 
   performed by a trained practitioner with therapeutic needles placed in the ears, 
   hands, abdomen, and lower extremities bilaterally. She was subsequently taken to 
   the operating room where we performed a TURBT of a bladder tumor overlying the 
   left ureteral orifice. The procedure was generally well tolerated and the patient 
   experienced mild pain. There were no perioperative complications. The tumor was 
   estimated to be 3 cm in largest diameter, and a total of 8 g of aggregate tissue 
   was sent to our pathologists. Pathology analysis demonstrated adequate resection 
   with detrusor muscle present in the sample. The bladder tumor was low-grade 
   papillary urothelial cell carcinoma (Stage Ta). She has had tumor recurrence and 
   has undergone repeat TURBT, but to date, she is 22 months free of bladder cancer. 
   Conclusion: In this case report, we demonstrate that acupuncture is a safe and 
   effective alternative to general anesthesia for patients undergoing TURBT. Since 
   tobacco use is prevalent among bladder cancer patients, many of these individuals 
   have associated medical comorbidities, which predispose them to high risk with 
   general anesthesia. Therefore, acupuncture may serve as an attractive alternative 
   for certain patients in this population.
C1 Department of Urology, University of Tennessee Health Science Center, Memphis, Tennessee.
   Department of Urology, University of Tennessee Health Science Center, Memphis, Tennessee.
   Department of Urology, University of Tennessee Health Science Center, Memphis, Tennessee.
   Department of Urology, University of Tennessee Health Science Center, Memphis, Tennessee.
   Department of Urology, University of Tennessee Health Science Center, Memphis, Tennessee.
   Department of Urology, University of Tennessee Health Science Center, Memphis, Tennessee.
   Department of Urology, University of Tennessee Health Science Center, Memphis, Tennessee.
   Member Medical Anesthesia Group, Department of Anesthesiology, University of Tennessee Health Science Center, Memphis, Tennessee.
   Department of Urology, University of Tennessee Health Science Center, Memphis, Tennessee.
NR 0
TC 0
SN 2379-988
EI 2379-988
J9 J Endourol Case Rep
PD AUG 11
PY 2020
VL 5
IS 4
BP 184
EP 186
DI 10.1089/cren.2019.0026 
PG 2
UT PubMed:32775660
PM 32775660
DA 2020-08-11
ER

PT J
AU Frankel, E
   Garland, S
   Meghani, SH
   Vapiwala, N
   Mao, JJ
AF Frankel, Eitan
   Garland, Sheila
   Meghani, Salimah H
   Vapiwala, Neha
   Mao, Jun J
TI Patients' Perspectives on Integrating Acupuncture into the Radiation Oncology 
SO European journal of integrative medicine
LA English
DT Journal Article
DE Acupuncture; CAM; health disparity; knowledge; pain; radiotherapy
AB INTRODUCTION: Acupuncture has potential as a supportive care service for cancer 
   symptom management. However, little is known about patients' willingness to use 
   acupuncture in the context of conventional cancer care. METHODOLOGY: We conducted 
   a cross-sectional survey study among patients with cancer during their last week 
   of fractionated/external beam radiotherapy (RT). The main outcome variable was 
   self-reported likelihood of using acupuncture during RT. Knowledge about 
   acupuncture and pain severity was measured along with socio-demographic and 
   clinical variables. Multivariate logistic regression was performed to identify 
   factors associated with willingness to use acupuncture. RESULTS: Among the 305 
   participants, 79 (26.4%) were likely to use acupuncture during RT if such 
   services were offered at a reasonable price, 143 (46.9%) had no knowledge of 
   acupuncture, and 206 (67.6%) reported having pain. In multivariate analyses, 
   non-Whites (adjusted odds ratio [AOR] 1.94, 95% Confidence Interval [CI] 
   1.06-3.56), and those with pain (AOR 2.52, CI 1.25-5.10) were more interested in 
   using acupuncture. In addition, patients with preexisting knowledge about 
   acupuncture were also more likely to use acupuncture than those without this 
   knowledge (AOR 2.23, CI 1.28-3.88). CONCLUSIONS: Patients of non-White race, 
   those with pain or those with prior knowledge about acupuncture were more willing 
   to utilize acupuncture during RT. Since half of the patients had no knowledge 
   about acupuncture, interventions to improve patients' knowledge are needed to 
   facilitate the successful integration of acupuncture into cancer care.
C1 Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
   Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 
   Abramson Cancer Center,Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
   Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 
   University of Pennsylvania School of Nursing,Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
   Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 
   Department of Radiation Oncology, PerelmanSchool of Medicine at the University of Pennsylvania, Philadelphia, PA.
   Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 
   Abramson Cancer Center,Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA ;Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicineat the University of Pennsylvania, Philadelphia, PA.
NR 0
TC 0
SN 1876-383
EI 1876-382
J9 Eur J Integr Med
PD NOV 12
PY 2014
VL 6
IS 5
BP 532
EP 537
DI 10.1016/j.eujim.2014.06.007 
PG 5
UT PubMed:25386224
PM 25386224
DA 2014-11-12
ER

PT J
AU McLarney, M
   Wechsler, SB
   Milani, SA
   Lyons, KD
   Pritchard, KT
AF McLarney, Mitra
   Wechsler, Stephen B
   Milani, Sadaf Arefi
   Lyons, Kathleen Doyle
   Pritchard, Kevin T
TI Trends in Opioids and Nonpharmacologic Pain Management Among U.S. Cancer 
SO Archives of physical medicine and rehabilitation
LA English
DT Journal Article
DE Allied health personnel; Facilities and services use; Health policy; Neoplasms; Opioid; Pain; Rehabilitation
AB OBJECTIVE: It is unknown how the United States (U.S.) opioid epidemic influenced 
   the integration of nonpharmacologic pain treatments in cancer survivors. We 
   described annual trends and predictors of using opioids alone, nonpharmacologic 
   treatments alone, multimodal treatments (opioid + nonpharmacologic), and neither 
   treatment. DESIGN: A serial cross-sectional design. SETTING: Ambulatory. 
   PARTICIPANTS: Noninstitutionalized U.S. adults with prevalent cancer and pain in 
   the Medical Expenditure Panel Survey (2011-2020). INTERVENTIONS: Not applicable. 
   MAIN OUTCOME MEASURES: Period prevalence of self-reported and pharmacy-verified 
   use of opioids alone, nonpharmacologic treatments alone, both, or neither. 
   Nonpharmacologic treatments included physical therapy, occupational therapy, 
   chiropractic care, massage therapy, and acupuncture. RESULTS: Respondents with 
   cancer and pain represented a total of 41,064,668 adults from 2011 to 2020. Most 
   adults with cancer pain were >65 years of age (66.6%), women (52.1%), White 
   (91.4%), non-Hispanic (95.8%), had a high school diploma (42.2%), had an income 
   of 400% of the federal poverty line (46.6%), and lived in the U.S. South (37.7%). 
   Compared with 2011, the prevalence of multimodal treatments increased from 4% 
   (95% confidence interval [CI], 2%-6%) to 10% (95% CI, 6%-14%) in 2019, while the 
   prevalence of using neither pain treatment decreased from 62% (95% CI, 55%-68%) 
   to 46% (95% CI, 40%-52%). Compared with using neither treatment, the adjusted 
   relative risk ratio (RRR) for using nonpharmacologic treatments was stable from 
   2011 to 2015 (RRR=1.00; 95% CI, 0.93-1.08), but increased from 2016 to 2019 
   (RRR=1.22; 95% CI, 1.02-1.46) until 2020 (RRR=0.68; 95% CI, 0.43-1.46). Both 
   unadjusted and adjusted analyses found that pain treatments varied based on 
   income, educational attainment, race, and geographic region. CONCLUSIONS: 
   Nonpharmacologic and multimodal pain treatments increased from 2011 to 2020; 
   however, most cancer pain survivors remained untreated. Pain treatment varied 
   based on sociodemographic and socioeconomic factors.
C1 Department of Physical Medicine and Rehabilitation, Harvard Medical School/Spaulding Rehabilitation Hospital, Boston, MA.
   Department of Physical Therapy, Simmons University, Boston, MA.
   Department of Epidemiology, University of Texas Medical Branch, Galveston, TX.
   Department of Occupational Therapy, MGH Institute of Health Professions, Boston, MA.
   Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA
   Division of Pharmacoepidemiology and Pharmacoeconomics, Department ofMedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
EM kpritchard3@bwh.harvard.edu
NR 0
TC 0
SN 1532-821
EI 
J9 Arch Phys Med Rehabil
PD DEC 5
PY 2025
VL 0
IS 
BP 
EP 
DI 10.1016/j.apmr.2025.11.019 
PG 0
UT PubMed:41344550
PM 41344550
DA 2025-12-05
ER

PT J
AU Li, Y
   Xu, R
   Chen, M
   Zheng, K
   Nie, H
   Yin, C
   Liu, B
   Tai, Y
   Du, J
   Wang, J
   Fang, J
   Liu, B
AF Li, Yuanyuan
   Xu, Ruoyao
   Chen, Muyan
   Zheng, Kaige
   Nie, Huimin
   Yin, Chengyu
   Liu, Boyu
   Tai, Yan
   Du, Junying
   Wang, Jie
   Fang, Jianqiao
   Liu, Boyi
TI Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by 
SO Chinese medicine
LA English
DT Journal Article
DE Acupuncture; Chemotherapy; Macrophages; Neuropathy; Paclitaxel; Pain
AB BACKGROUND: Paclitaxel-induced peripheral neuropathy (PIPN) is prevalent among 
   patients receiving paclitaxel chemotherapy, which results in sensory abnormality 
   as well as neuropathic pain. Conventional medications lack effectiveness on PIPN. 
   Clinical trials identified beneficial effects of acupuncture on PIPN among 
   patients receiving chemotherapy. Here we explored the mechanisms underlying how 
   acupuncture might alleviate PIPN. METHODS: A mouse model of PIPN was established 
   by repeated paclitaxel application. Electroacupuncture (EA) was applied at ST36 
   and BL60 acupoints of model mice. Immunostaining, flow cytometry, behavioral 
   assay, in vivo imaging were utilized for effects determination and mechanism 
   exploration. RESULTS: EA ameliorated mechanical and cold pain hypersensitivities, 
   reduced sensory neuron damage and improved loss in intra-epidermal nerve fibers 
   (IENFs) in model mice. Macrophages infiltration were detected in DRG and sciatic 
   nerve of model mice, which was reduced by EA. EA affected M1-like 
   pro-inflammatory macrophage infiltration in DRG, whereas it did not affect 
   M2-like macrophages. DRG neurons released chemoattractant CCL2 that recruited 
   macrophages via CCR2 to DRG. EA reduced CCL2 overproduction by DRG neurons and 
   reduced macrophage infiltration. Blocking CCR2 mimicked EA's anti-allodynic 
   effect, whereas exogenously applying recombinant CCL2 reversed the ameliorative 
   effect of EA on macrophage infiltration and abolished EA's anti-allodynia on 
   model mice. EA ameliorated other signs of PIPN, including sensory neuron damage, 
   sciatic nerve morphology impairment and IENFs loss. In mice inoculated with 
   breast cancer cells, EA didn't affect paclitaxel-induced antitumor effect. 
   CONCLUSIONS: These findings suggest EA alleviates PIPN by reducing CCL2/CCR2 
   mediated-pro-inflammatory macrophage infiltration into sensory ganglia as well as 
   the sciatic nerve. Our study supports EA could be used as a potential 
   non-pharmacological therapy for PIPN.
C1 Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, Hangzhou, China.
   Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Rehabilitation in Traditional Chinese Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.wangjiee@zju.edu.cn.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, Hangzhou, China. fangjianqiao7532@163.com.
   Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Key Laboratory of Acupuncture and Neurology of Zhejiang Province,Zhejiang Chinese Medical University, Hangzhou, China. boyi.liu@foxmail.com.
NR 0
TC 0
SN 1749-854
EI 1749-854
J9 Chin Med
PD JAN 14
PY 2025
VL 20
IS 1
BP 9
EP 9
DI 10.1186/s13020-024-01023-8 
PG 0
UT PubMed:39806462
PM 39806462
DA 2025-01-14
ER

PT J
AU Federman, DG
   Holleck, JL
AF Federman, Daniel G
   Holleck, Jurgen L
TI Auricular Acupuncture and Skin-Cancer Detection: An Opportunity.
SO Medical acupuncture
LA English
DT Journal Article
DE auricular acupuncture; basal-cell carcinoma; squamous-cell carcinoma
AB Background: Auricular acupuncture is effective for many patients with pain. Many 
   skin malignancies and precancerous lesions are found on the head and neck. 
   Practitioners of acupuncture are in a unique situation to detect cutaneous 
   malignancy at an early state. Case: An 83-year-old man referred for Battlefield 
   Acupuncture was found to have a scalp lesion suspicious for malignancy as well as 
   several precancerous lesions. Results: Referral to a dermatologist led to 
   excision of a basal-cell cancer and treatment of actinic keratoses. Conclusions: 
   Practitioners of auricular acupuncture should be familiar with common skin 
   cancers and precancerous lesions; these practitioners are in a unique situation 
   to detect these common skin lesions.
C1 Department of Medicine, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, CT.
   Department of Medicine, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, CT.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD FEB 8
PY 2018
VL 30
IS 1
BP 39
EP 40
DI 10.1089/acu.2017.1261 
PG 1
UT PubMed:29410720
PM 29410720
DA 2018-02-08
ER

PT J
AU Lyu, Z
   Shen, Q
   Tian, S
   Gong, L
   Lou, H
   Bao, G
   Wu, Z
   Lu, C
   Zhang, W
   Huang, R
   Ji, C
   Zheng, S
   Pan, W
   Ying, Y
   Jin, J
   Liang, Y
AF Lyu, Zhengyi
   Shen, Qiongying
   Tian, Shuxin
   Gong, Liyan
   Lou, Haizhou
   Bao, Guanai
   Wu, Zhuoxuan
   Lu, Chao
   Zhang, Weiping
   Huang, Rui
   Ji, Conghua
   Zheng, Siyi
   Pan, Wei
   Ying, Yinyin
   Jin, Jianwei
   Liang, Yi
TI Effects of Patient-Controlled Transcutaneous Electrical Acupoint Stimulation on 
SO Journal of pain research
LA English
DT Journal Article
DE TEAS; bone cancer pain; home-based treatment; integrative medicine; patient-controlled analgesia; transcutaneous electrical nerve stimulation
AB BACKGROUND: Transcutaneous Electrical Acupoint Stimulation (TEAS) therapy opens 
   up the possibility for individuals with Cancer-induced bone pain (CIBP) to 
   receive a home-based, patient-controlled approach to pain management. The aim of 
   this study is designed to evaluate the efficacy of patient-controlled TEAS 
   (PC-TEAS) for relieving CIBP in patients with non-small cell lung cancer (NSCLC). 
   METHODS/DESIGN: This is a study protocol for a prospective, triple-blind, 
   randomized controlled trial. We anticipate enrolling 188 participants with NSCLC 
   bone metastases who are also using potent opioid analgesics from 4 Chinese 
   medical centers. These participants will be randomly assigned in a 1:1 ratio to 
   either the true PC-TEAS or the sham PC-TEAS group. All participants will receive 
   standard adjuvant oncology therapy. The true group will undergo 
   patient-controlled TEAS intervention as needed, while the sham group will follow 
   the same treatment schedule but with non-conductive gel patches. Each treatment 
   course will span 7 days, with a total of 4 courses administered. There will be 4 
   assessment time points: baseline, the conclusion of weeks 4, 8, and 12. The 
   primary outcome of this investigation is the response rate of the average pain on 
   the Brief Pain Inventory (BPI) scale at week 4 after treatment. Secondary 
   outcomes include pain related indicators, quality of life scale, mood scales, and 
   routine blood counts on the assessment days. Any adverse events will be promptly 
   addressed and reported if they occur. We will manage trial data using the EDC 
   platform, with a data monitoring committee providing regular quality oversight. 
   DISCUSSION: PC-TEAS interventions offer an attempt to achieve home-based 
   acupuncture treatment and the feasibility of achieving triple blinding in 
   acupuncture research. This study is designed to provide more rigorous trial 
   evidence for the adjuvant treatment of cancer-related pain by acupuncture and to 
   explore a safe and effective integrative medicine scheme for CIBP. TRIAL 
   REGISTRATION: ClinicalTrials.gov NCT05730972, registered February 16, 2023.
C1 The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
   The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
   The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
   Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People's Republic of China.
   Department of Medical Oncology, Sir Run Run Shaw Hospital, Hangzhou, Zhejiang, People's Republic of China.
   Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People's Republic of China.
   Department of Medical Oncology, Sir Run Run Shaw Hospital, Hangzhou, Zhejiang, People's Republic of China.
   Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People's Republic of China.
   Department of Acupuncture, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
   Department of Acupuncture and Tuina, Wenzhou Central Hospital, Wenzhou, Zhejiang, People's Republic of China.
   Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
   The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
   The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
   Department of Acupuncture, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
   Department of Acupuncture, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
   Department of Acupuncture, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD APR 1
PY 2024
VL 17
IS 
BP 1285
EP 1298
DI 10.2147/JPR.S437296 
PG 13
UT PubMed:38560406
PM 38560406
DA 2024-04-01
ER

PT J
AU Djaali, W
   Simadibrata, CL
   Nareswari, I
AF Djaali, Wahyuningsih
   Simadibrata, Christina Lanny
   Nareswari, Irma
TI Acupuncture Therapy in Post-Radiation Head-and-Neck Cancer with Dysgeusia.
SO Medical acupuncture
LA English
DT Journal Article
DE acupuncture; dysgeusia; head-and-neck cancer; radiation therapy
AB Background: Radiation therapy for head-and-neck cancer can cause side-effects, 
   including pain, nausea, vomiting, sensory disorders such as anosmia and 
   dysgeusia, dysphagia, xerostomia, hot flashes, fatigue, sleep disorders, and even 
   anxiety and depression disorders. Therapies using acupuncture are now being 
   adopted at cancer therapy centers. Acupuncture has been clinically proven to 
   reduce the side-effects of cancer therapies, thus, resulting in better quality of 
   life. Case: A 65-year-old man was diagnosed with stage I laryngeal squamous-cell 
   carcinoma (SCC), and had missing taste and pain on swallowing (visual analogue 
   scale [VAS]: 4) after undergoing 30 sessions of radiation therapy for 
   head-and-neck cancer with a total radiation dose of 60 Gy. He received 
   acupuncture at: body points (LI 4 Hegu, LR 3 Taichong, ST 36 Zusanli, SP 6 
   Sanyinjiao, and ST 40 Fenglong); the Battlefield Acupuncture points of the ear 
   (Cingulate Gyrus, Thalamus, Zero Point, Shen Men, and Omega 2); and on the wrist 
   area (according to a balance method). Acupuncture therapy was given 2 times a 
   week, for 45-minute sessions. Results: After 12 acupuncture sessions, he had 
   improvement in taste function and pain reduction from VAS 4 to VAS 1. This 
   improvement likely occurred due to acupuncture's anti-inflammatory effects 
   through anti-inflammatory mediator secretion, an antipain effect through 
   ß-endorphin secretion, and nerve-cell regeneration through neurotropic factors' 
   secretion. Conclusions: Routine acupuncture therapy can reduce dysgeusia and pain 
   in postradiated patients with head-and-neck cancer. Acupuncture can be a 
   therapeutic choice for patients with post-radiation head-and-neck cancer 
   toxicity.
C1 Universitas Negeri Jakarta, East Jakarta, Jakarta, Indonesia.
   Department of Medical Acupuncture, Faculty of Medicine, Universitas 
   Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Jakarta, Indonesia.
   Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Jakarta, Indonesia.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD JUL 1
PY 2020
VL 32
IS 3
BP 157
EP 162
DI 10.1089/acu.2020.1410 
PG 5
UT PubMed:32595823
PM 32595823
DA 2020-07-01
ER

PT J
AU Huang, CC
   Ho, TJ
   Ho, HY
   Chen, PY
   Tu, CH
   Huang, YC
   Lee, YC
   Sun, MF
   Chen, YH
AF Huang, Chien-Chen
   Ho, Tsung-Jung
   Ho, Hsin-Yueh
   Chen, Pei-Yu
   Tu, Cheng-Hao
   Huang, Yu-Chuen
   Lee, Yu-Chen
   Sun, Mao-Feng
   Chen, Yi-Hung
TI Acupuncture Relieved Chemotherapy-Induced Peripheral Neuropathy in Patients with 
SO Journal of clinical medicine
LA English
DT Journal Article
DE Semmes–Weinstein monofilament; acupuncture; breast cancer; chemotherapy; neuropathic pain; peripheral neuropathy
AB Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect 
   caused by neurotoxic chemotherapy. This randomized controlled trial aimed to 
   evaluate the effect of manual acupuncture on CIPN. Twenty eligible breast cancer 
   patients receiving taxane chemotherapy treatment were recruited and randomly 
   divided into verum acupuncture and sham acupuncture groups. Each group received 
   15 treatments over 9 weeks. Quantitative tactile detection thresholds were 
   measured using Semmes-Weinstein monofilament testing (SWM). The World Health 
   Organization Quality of Life scale (WHOQOL-BREF), the Functional Assessment of 
   Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), and the 
   Brief Pain Inventory-Short Form (BPI-SF) were measured before and after 
   treatment. The between-group comparison of SWM revealed that the verum 
   acupuncture group had more improvement of touch perception thresholds compared to 
   the sham acupuncture group. The average pain severity in the BPI-SF of the verum 
   acupuncture group was significantly lower than that of the sham acupuncture 
   group. There were no significant differences in the FACT/GOG-Ntx trial outcome 
   index and WHOQOL-BREF scores between the acupuncture and sham groups. The results 
   suggest that acupuncture can alleviate the neuropathic pain of CIPN and improve 
   touch perception thresholds.
C1 Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
   Department of Traditional Chinese Medicine, An Nan Hospital, China Medical 
   Department of Chinese Medicine, Hualien Tzu Chi Hospital, Hualien 970, Taiwan.
   School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 
   Integration Center of Traditional Chinese and Modern Medicine, Hualien Tzu Chi Hospital, Hualien 970, Taiwan.
   Department of Surgery, An Nan Hospital, China Medical University, Tainan City 709, Taiwan.
   Cancer Center, An Nan Hospital, China Medical University, Tainan City 709, Taiwan.
   Graduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan.
   Department of Medical Research, China Medical University Hospital, School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
   Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
   Department of Acupuncture, China Medical University Hospital, Taichung 404332, 
   Graduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan.
   Department of Acupuncture, China Medical University Hospital, Taichung 404332, 
   Graduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan.
   Chinese Medicine Research Center, China Medical University, Taichung 40402, 
   Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan.
NR 0
TC 0
SN 2077-038
EI 2077-038
J9 J Clin Med
PD AUG 28
PY 2021
VL 10
IS 16
BP 
EP 
DI 10.3390/jcm10163694 
PG 0
UT PubMed:34441990
PM 34441990
DA 2021-08-28
ER

PT J
AU Jiang, Y
   Wu, L
   Wang, Y
   Tan, J
   Wang, L
   Cai, J
   Zhou, Y
   Sun, G
   Song, Z
   Gu, L
AF Jiang, Yueyi
   Wu, Lei
   Wang, Yue
   Tan, Jing
   Wang, Li
   Cai, Jiaqin
   Zhou, Yihu
   Sun, Guowei
   Song, Zhenghuan
   Gu, Lianbing
TI Effects of Press Needling combined with general anesthesia on postoperative 
SO Complementary therapies in medicine
LA English
DT Journal Article
DE Analgesia; Lung surgery; Postoperative pulmonary complications; Press needle acupuncture; Video-assisted thoracoscopic surgery
AB OBJECTIVES: To investigate the effects of press needle therapy on postoperative 
   analgesia and other relevant complications in patients undergoing thoracoscopic 
   pulmonary resection. DESIGN: randomized, single-blind, controlled trial SETTING: 
   Teaching hospitals affiliated with universities. INTERVENTIONS: Eighty-six 
   patients were randomized into: the Acu group (press-needle group) and the control 
   group MAIN OUTCOME MEASURES: Pain levels 24, 48, and three months after surgery 
   were measured using the numeric rating scale (NRS). Perioperative hemodynamics, 
   total and effective pressing numbers of patient-controlled intravenous analgesia 
   (PCIA), and incidence of postoperative pulmonary complications were recorded. 
   Peripheral blood samples were collected to measure the levels of inflammatory 
   mediators RESULTS: Acu group had significantly lower NRS scores at 24 and 48 h 
   after operation (NRS scores on movement at 24 h after surgery: Acu vs. Control, 3 
   (2,3) vs. 3 (3,5), Z = -3.393, P < 0.01 and NRS scores on movement at 48 h after 
   surgery: 2 (1,3) vs. 3 (2,5), Z = -3.641, P < 0.01), lower number of PCIA 
   attempts and effective rates (mean total pressing numbers: 4(2,8) vs. 6(3,19), 
   Z = -1.994, P = 0.046 and mean effective pressing numbers: 3(2,8) vs. 6(3,16), 
   Z = -2.116, P = 0.034). The Acu group had significantly reduced IL-1 
   (14.52 ± 3.84 vs. 16.36 ± 3.30, mean difference (MD): - 1.85, 95% confidence 
   interval (CI): - 3.46, - 0.23, P = 0.026), HIF-1α (10.15 ± 1.71 vs. 10.96 ± 1.73, 
   MD: -0.81, 95% CI: -1.59, -0.04, P = 0.040) and the incidence of pulmonary 
   complications after surgery. CONCLUSION: Press needles are a non-invasive and 
   feasible adjunctive intervention for postoperative analgesic management in 
   patients undergoing thoracoscopic pulmonary resection.
C1 Nanjing Medical University, Nanjing, People's Republic of China.
   Department of Anesthesiology, Jiangsu Cancer Hospital, Nanjing, People's Republic of China.
   Nanjing Medical University, Nanjing, People's Republic of China.
   Department of Anesthesiology, Jiangsu Cancer Hospital, Nanjing, People's Republic of China.
   Department of Anesthesiology, Jiangsu Cancer Hospital, Nanjing, People's Republic of China.
   Xuzhou Medical University, Xuzhou, People's Republic of China.
   Nanjing Medical University, Nanjing, People's Republic of China.
   Dalian Medical University, Dalian, People's Republic of China.
   Department of Anesthesiology, Jiangsu Cancer Hospital, Nanjing, People's Republic of China. 
   Nanjing Medical University, Nanjing, People's Republic of China
   Department of Anesthesiology, Jiangsu Cancer Hospital, Nanjing, People's Republic of China.
EM 13951947684@163.com
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD AUG 29
PY 2023
VL 77
IS 
BP 102980
EP 102980
DI 10.1016/j.ctim.2023.102980 
PG 0
WC Humans; Single-Blind Method; Lung Neoplasms; surgery; Anesthesia, General; Postoperative Complications; Analgesia
UT PubMed:37640166
PM 37640166
DA 2023-08-29
ER

PT J
AU Dymackova, R
   Selingerova, I
   Kazda, T
   Slavik, M
   Halamkova, J
   Svajdova, M
   Slampa, P
   Slama, O
AF Dymackova, Radana
   Selingerova, Iveta
   Kazda, Tomas
   Slavik, Marek
   Halamkova, Jana
   Svajdova, Michaela
   Slampa, Pavel
   Slama, Ondrej
TI Effect of Acupuncture in Pain Management of Head and Neck Cancer Radiotherapy: 
SO Journal of clinical medicine
LA English
DT Journal Article
DE acupuncture; head and neck cancer; pain; radiotherapy; toxicity
AB This prospective randomized open-label trial aimed to evaluate the role of 
   acupuncture in the treatment of pain related to curative and adjuvant 
   (chemo)radiotherapy of head and neck cancer. Patients in two arms (30 patients in 
   each arm) underwent standard oncology therapy and standard supportive care with 
   or without acupuncture. The stratification factors were the type of treatment and 
   chemotherapy indication. The toxicity assessed was represented by pain rated on a 
   10-point pain scale and analgesic use. Average pain (AP) and the worst pain 
   during the day (WP) were significantly lower in the acupuncture arm during 
   radiotherapy (AP median 0.16 vs. 1.36, p < 0.001; WP median 0.90 vs. 1.96, p < 
   0.001) and three months after radiotherapy (AP median 0.07 vs. 0.50, p < 0.001; 
   WP median 0.30 vs. 0.83, p = 0.002). The analgesic consumption between arms was 
   statistically significantly different. A median of the proportion of days when 
   the patients used analgesics was 8% and 32.5% during radiotherapy (p = 0.047) and 
   0% and 20.8% during three months after radiotherapy (p = 0.006) for the 
   acupuncture and control arm, respectively. Results point out lower analgesic 
   consumption and milder pain in acupuncture arm. Acupuncture consequently offers 
   another alternative to standard treatment leading to a reduction in the toxicity 
   of oncological treatment.
C1 Department of Radiation Oncology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
   Department of Radiation Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, 
   Research Center for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
   Department of Radiation Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
   Research Center for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer 
   Department of Radiation Oncology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
   Department of Radiation Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, 
   Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
   Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, 656 
   Department of Radiation Oncology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
   Clinic of Radiation and Clinical Oncology, Central Military Hospital-Teaching 
   Department of Radiation Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
   Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
NR 0
TC 0
SN 2077-038
EI 2077-038
J9 J Clin Med
PD APR 4
PY 2021
VL 10
IS 5
BP 
EP 
DI 10.3390/jcm10051111 
PG 0
UT PubMed:33799949
PM 33799949
DA 2021-04-04
ER

PT J
AU Zheng, K
   Hong, X
   Jiang, C
   Chen, Y
AF Zheng, Kanghua
   Hong, Xiaoping
   Jiang, Changyin
   Chen, Yong
TI Effects of warming needle moxibustion on postoperative rehabilitation, pain 
SO American journal of cancer research
LA English
DT Journal Article
DE Functional rehabilitation training; immune function; radical mastectomy; upper limb lymphedema; warming needle moxibustion
AB This study aims to evaluate the effects of warm acupuncture combined with 
   conventional functional rehabilitation training (FRT) on the recovery of breast 
   cancer (BC) patients following radical mastectomy, focusing on immune function, 
   pain management, and quality of life (QoL). This retrospective study involved 118 
   BC patients who underwent radical surgery at the Second People's Hospital 
   Affiliated to Fujian University of Chinese Medicine between January 2022 and May 
   2024. The included patient were assigned into an experimental group (EG, n=62, 
   warm acupuncture in conjunction with conventional FRT) and a control group (CG; 
   n=56; conventional FRT only). Postoperative outcomes, including surgery duration, 
   intraoperative blood loss (IOBL), drainage volume (DV), length of hospital stay, 
   upper limb mobility, immune function indicators, and pain scores, were compared 
   between the two groups. Multivariate logistic regression was employed to identify 
   factors affecting treatment outcomes. The EG demonstrated significantly lower 
   visual analog scale (VAS) scores at post-operative 2, 4, and 8 weeks compared to 
   the CG (all P < 0.05). The incidence of upper limb lymphedema in the EG was 
   9.26%, notably lower than the 24.07% observed in the CG (P < 0.05). Immune 
   function indicators, including CD3(+), CD4(+), CD8(+), and the CD4(+)/CD8(+) 
   ratio, were significantly higher in the EG postoperatively (P < 0.05). 
   Furthermore, the EG reported significantly improved scores in role physical, 
   general health, vitality, social functioning, role emotional, mental health, and 
   physiological functioning, alongside significantly lower scores in bodily pain 
   compared to the CG (all P < 0.05). Multivariate logistic regression analysis 
   revealed CD3(+) and CD4(+)/CD8(+) ratio as independent factors affecting patient 
   treatment efficacy (both P < 0.05). In conclusion, the combination of warm 
   acupuncture and conventional FRT significantly enhances immune function, pain 
   management, and overall QoL in BC patients after surgery, with CD3(+) and 
   CD4(+)/CD8(+) ratios being crucial factors influencing recovery.
C1 Department of Rehabilitation, The Second People's Hospital Affiliated to Fujian University of Chinese Medicine Fuzhou 350003, Fujian, China.
   Department of Rehabilitation, The Second People's Hospital Affiliated to Fujian University of Chinese Medicine Fuzhou 350003, Fujian, China.
   Department of Rehabilitation, The Second People's Hospital Affiliated to Fujian University of Chinese Medicine Fuzhou 350003, Fujian, China.
   Department of Pathophysiology, College of Integrative Medicine, Fujian University of Traditional Chinese Medicine Fuzhou 350122, Fujian, China.
NR 0
TC 0
SN 2156-697
EI 2156-697
J9 Am J Cancer Res
PD APR 14
PY 2025
VL 15
IS 3
BP 991
EP 1001
DI 10.62347/YXHG6188 
PG 10
UT PubMed:40226461
PM 40226461
DA 2025-04-14
ER

PT J
AU Giovanardi, CM
   Poini, A
   Allais, G
AF Giovanardi, Carlo Maria
   Poini, Alessandra
   Allais, Gianni
TI Editorial: Acupuncture to treat pain in specific body regions.
SO Frontiers in pain research (Lausanne, Switzerland)
LA English
DT Editorial
DE Battlefield acupuncture (BFA); acupuncture; acute pain analgesia; cancer survivors; endometriosis; gouty arthritis pain; musculoskeletal pain; pain
C1 Association of Medical Acupuncturists of Bologna (A.M.A.B.), Research and Healthcare Institute, Bologna, Italy.
   Association of Medical Acupuncturists of Bologna (A.M.A.B.), Research and Healthcare Institute, Bologna, Italy.
   Women's Headache Center and Service for Acupuncture in Obstetrics and Gynecology, University of Turin, Turin, Italy.
NR 0
TC 0
SN 2673-561
EI 2673-561
J9 Front Pain Res (Lausanne)
PD JUN 24
PY 2024
VL 5
IS 
BP 1421548
EP 1421548
DI 10.3389/fpain.2024.1421548 
PG 0
UT PubMed:38911022
PM 38911022
DA 2024-06-24
ER

PT J
AU Zhao, Y
   Cao, W
   Zhang, H
   Rong, Q
   He, M
   Wu, M
   Zhao, Y
   Yang, P
AF Zhao, Yi
   Cao, Wendi
   Zhang, Hengheng
   Rong, Qingxi
   He, Mingxuan
   Wu, Meijie
   Zhao, Yi
   Yang, Ping
TI The efficacy of acupuncture in the treatment of chemotherapy-induced peripheral 
SO Journal of cancer survivorship : research and practice
LA English
DT Review
DE Acupuncture; Cancer supportive care; Meta-analysis; Peripheral nervous system diseases; Systematic review
AB PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side 
   effect in cancer patients, often emerging within the first month of chemotherapy. 
   Severe CIPN can disrupt daily life, necessitating chemotherapy adjustments or 
   discontinuation, which may increase cancer mortality. No standardized treatment 
   exists, but acupuncture is widely used in China for CIPN.This study aimed to 
   comprehensively assess the actual efficacy of acupuncture in treating CIPN in 
   cancer patients. METHODS: We searched PubMed, Web of Science, Embase, and 
   Cochrane Library up to October 2024 for randomized controlled trials (RCTs) on 
   acupuncture for CIPN, following the Preferred Reporting Items for Systematic 
   Reviews and Meta-Analyses (PRISMA). Methodological quality was assessed using the 
   Cochrane risk-of-bias tool (RoB 2.0) and the modified Jadad scale. A 
   random-effects model was used to analyze the Effect Size (ES) and 95% Confidence 
   Interval (CI).Data analysis was performed using RevMan 5.3 software. RESULTS: The 
   final analysis incorporated 1,048 patients from 18 studies. The results presented 
   in the forest plot demonstrated that, when compared to the control group, 
   acupuncture exhibited superior efficacy in improving CIPN symptoms (RR = 1.11, 
   95%CI [1.01,1.21]), alleviating pain (SMD = -0.93, 95%CI [-1.63,-0.22]), 
   enhancing quality of life (QoL) (MD =  - 1.14, 95%CI [- 1.97, - 0.31]), and 
   reducing chemotherapy-related neurotoxicity (MD =  - 3.34, 95%CI 
   [- 5.24, - 1.44]). Additionally, in alleviating CIPN-related pain, simple 
   acupuncture demonstrates superior efficacy compared to electroacupuncture. 
   CONCLUSION: This study clearly demonstrates that acupuncture offers more 
   substantial benefits to CIPN patients compared to usual care, medication, 
   vitamin, and sham acupuncture. This research serves as a valuable reference for 
   cancer patients, physicians, nurses, and other professional medical 
   practitioners.
C1 Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000,China.
   Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000,China.
   Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000,China.
   Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000,China.
   Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000,China.
   Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000,China.
   Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000,China. zywm0001@163.com.
   Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000,China. 1290912204@qq.com.
NR 0
TC 0
SN 1932-226
EI 
J9 J Cancer Surviv
PD AUG 20
PY 2025
VL 0
IS 
BP 
EP 
DI 10.1007/s11764-025-01869-3 
PG 0
UT PubMed:40830723
PM 40830723
DA 2025-08-20
ER

PT J
AU Frączek, P
   Kilian-Kita, A
   Püsküllüoglu, M
   Krzemieniecki, K
AF Frączek, Paulina
   Kilian-Kita, Aneta
   Püsküllüoglu, Mirosława
   Krzemieniecki, Krzysztof
TI Acupuncture as anticancer treatment?
SO Contemporary oncology (Poznan, Poland)
LA English
DT Review
DE acupuncture; anticancer treatment; cancer; complementary treatment; therapy
AB The mystery of Traditional Chinese Medicine has been attracting people for years. 
   Acupuncture, ranked among the most common services of Complementary and 
   Alternative Medicine, has recently gained a lot of interest in the scientific 
   world. Contemporary researchers have been continuously trying to shed light on 
   its possible mechanism of action in human organism. Numerous studies pertaining 
   to acupuncture's application in cancer symptoms or treatment-related side effects 
   management have already been published. Moreover, since the modern idea of 
   acupuncture's immunomodulating effect seems to be promising, scientists have 
   propounded a concept of its potential application as part of direct anti-tumor 
   therapy. In our previous study we summarized possible use of acupuncture in 
   management of cancer symptoms and treatment-related ailments, such as 
   chemotherapy-induced nausea and vomiting, pain, xerostomia, vasomotor symptoms, 
   neutropenia, fatigue, anxiety, insomnia, lymphoedema after mastectomy and 
   peripheral neuropathy. This article reviews the studies concerning acupuncture as 
   a possible tool in modern anticancer treatment.
C1 Department of Oncology Jagiellonian University, Krakow, Poland.
   Department of Oncology Jagiellonian University, Krakow, Poland.
   Department of Oncology Jagiellonian University, Krakow, Poland.
   Department of Oncology Jagiellonian University, Krakow, Poland.
NR 0
TC 0
SN 1897-430
EI 1428-252
J9 Contemp Oncol (Pozn)
PD FEB 28
PY 2017
VL 20
IS 6
BP 453
EP 457
DI 10.5114/wo.2016.65604 
PG 4
UT PubMed:28239282
PM 28239282
DA 2017-02-28
ER

PT J
AU Altawili, AA
   Altawili, MA
   Alzarar, AH
   Abdulrahim, NM
   Alquraish, HH
   Alahmari, MA
   Basyouni, MH
   Almohaya, YA
   Alhabshan, WMS
   Alshahrani, AMA
   Alamrad, JFA
   Aljumaah, AS
   Alsalman, MA
   Alhafith, AA
AF Altawili, Abdullh A
   Altawili, Mohammed A
   Alzarar, Amnah H
   Abdulrahim, Noor M
   Alquraish, Haidar H
   Alahmari, Maryam A
   Basyouni, Marouj H
   Almohaya, Yara A
   Alhabshan, Wafa Mohammed S
   Alshahrani, Abdullah Mohammed A
   Alamrad, Jafar Faraj A
   Aljumaah, Ahmad S
   Alsalman, Mohammed A
   Alhafith, Abdullah A
TI Adverse Events of the Long-Term Use of Opioids for Chronic Non-cancer Pain: A 
SO Cureus
LA English
DT Review
DE chronic pain; cncp; long-term; non-cancer; opioids; review
AB BACKGROUND: The long-term use of opioids for chronic non-cancer pain (CNCP) has 
   drawn more attention and debate. Although opioids are frequently used to treat 
   chronic pain, their effectiveness and safety over extended periods are still 
   unknown. OBJECTIVES: The purpose of this review is to provide an overview of what 
   is currently known about the adverse events of long-term use of opioids in CNCP. 
   It also delivers patient-centered strategies designed to mitigate these risks. 
   METHODS: We conducted a literature search in PubMed, MEDLINE, EMBASE, and Web of 
   Science databases. Search terms included CNCP, pain pathophysiology, opioid 
   pharmacodynamics, opioid prescribing trends, guidelines for opioid use, and 
   opioid side effects.  Results: Our review highlights that while opioids may 
   provide short-term relief from CNCP, their effectiveness diminishes over time due 
   to the development of opioid tolerance. This tolerance often leads to increased 
   dosages, which can subsequently result in opioid dependence. Additionally, 
   long-term opioid therapy is associated with a spectrum of adverse effects, 
   including constipation, drowsiness, respiratory depression, and potential for 
   drug interactions. Furthermore, our review indicates that alternative pain 
   management strategies play a crucial role in controlling CNCP. They offer 
   significant benefits with fewer adverse events. These strategies include 
   non-opioid medications, physical therapy, cognitive-behavioral therapy (CBT), 
   various interventional procedures, injection therapy, and acupuncture. 
   CONCLUSION: Using opioids to manage CNCP presents several challenges. Given these 
   challenges, alternative treatments are being considered as viable options. 
   Moreover, it is crucial to customize treatment plans to align with the patients' 
   specific health requirements, existing conditions, and potential risks to ensure 
   the best possible outcomes.
C1 Internal Medicine and Gastroenterology, King Fahad Specialist Hospital, Tabuk, SAU.
   College of Medicine, Alaziziyah Primary Health Care Center, Tabuk, SAU.
   College of Medicine, Najran University, Najran, SAU.
   College of Medicine, Batterjee Medical College, Jeddah, SAU.
   General Medicine, Dhahran Long Term Care Hospital, Dhahran, SAU.
   College of Medicine, King Khalid University, Khamis Mushait, SAU.
   College of Medicine, Batterjee Medical College, Jeddah, SAU.
   College of Medicine, King Khalid University, Abha, SAU.
   College of Medicine, King Khalid University, Khamis Mushait, SAU.
   General Medicine, Alsnaeyah Primary Health Center, Khamis Mushait, SAU.
   General Medicine, Dhahran Long Term Care Hospital, Dhahran, SAU.
   College of Medicine, King Saud University, Riyadh, SAU.
   General Medicine, Prince Saud Ben Jalawi Hospital, Al-Ahsa, SAU.
   College of Medicine, King Faisal University, Al-Hafouf, SAU.
NR 0
TC 0
SN 2168-818
EI 2168-818
J9 Cureus
PD FEB 1
PY 2024
VL 16
IS 1
BP e51475
EP e51475
DI 10.7759/cureus.51475 
PG 1
UT PubMed:38298287
PM 38298287
DA 2024-02-01
ER

PT J
AU Wang, Y
   Lei, J
   Gupta, M
   Peng, F
   Lam, S
   Jha, R
   Raduenz, E
   Beitz, AJ
   Gupta, K
AF Wang, Ying
   Lei, Jianxun
   Gupta, Mihir
   Peng, Fei
   Lam, Sarah
   Jha, Ritu
   Raduenz, Ellis
   Beitz, Al J
   Gupta, Kalpna
TI Electroacupuncture in conscious free-moving mice reduces pain by ameliorating 
SO Scientific reports
LA English
DT Journal Article
AB Integrative approaches such as electroacupuncture, devoid of drug effects are 
   gaining prominence for treating pain. Understanding the mechanisms of 
   electroacupuncture induced analgesia would benefit chronic pain conditions such 
   as sickle cell disease (SCD), for which patients may require opioid analgesics 
   throughout life. Mouse models are instructive in developing a mechanistic 
   understanding of pain, but the anesthesia/restraint required to administer 
   electroacupuncture may alter the underlying mechanisms. To overcome these 
   limitations, we developed a method to perform electroacupuncture in conscious, 
   freely moving, unrestrained mice. Using this technique we demonstrate a 
   significant analgesic effect in transgenic mouse models of SCD and cancer as well 
   as complete Freund's adjuvant-induced pain. We demonstrate a comprehensive 
   antinociceptive effect on mechanical, cold and deep tissue hyperalagesia in both 
   genders. Interestingly, individual mice showed a variable response to 
   electroacupuncture, categorized into high-, moderate-, and non-responders. 
   Mechanistically, electroacupuncture significantly ameliorated inflammatory and 
   nociceptive mediators both peripherally and centrally in sickle mice correlative 
   to the antinociceptive response. Application of sub-optimal doses of morphine in 
   electroacupuncture-treated moderate-responders produced equivalent 
   antinociception as obtained in high-responders. Electroacupuncture in conscious 
   freely moving mice offers an effective approach to develop a mechanism-based 
   understanding of analgesia devoid of the influence of anesthetics or restraints.
C1 Vascular Biology Center, Division of Hematology, Oncology &Transplantation, Department of Medicine, University of Minnesota, 14-100 PWB, 516 Delaware ST SE,Minneapolis, MN 55455, USA.
   Vascular Biology Center, Division of Hematology, Oncology &Transplantation, Department of Medicine, University of Minnesota, 14-100 PWB, 516 Delaware ST SE,Minneapolis, MN 55455, USA.
   Department of Neurosurgery, University of California San Diego, 200 West Arbor Drive #8893, La Jolla, CA 92103-8893, USA.
   Vascular Biology Center, Division of Hematology, Oncology &Transplantation, Department of Medicine, University of Minnesota, 14-100 PWB, 516 Delaware ST SE,Minneapolis, MN 55455, USA.
   Vascular Biology Center, Division of Hematology, Oncology &Transplantation, Department of Medicine, University of Minnesota, 14-100 PWB, 516 Delaware ST SE,Minneapolis, MN 55455, USA.
   Vascular Biology Center, Division of Hematology, Oncology &Transplantation, Department of Medicine, University of Minnesota, 14-100 PWB, 516 Delaware ST SE,Minneapolis, MN 55455, USA.
   Vascular Biology Center, Division of Hematology, Oncology &Transplantation, Department of Medicine, University of Minnesota, 14-100 PWB, 516 Delaware ST SE,Minneapolis, MN 55455, USA.
   Department of Veterinary and Biomedical Sciences, University of Minnesota, 295 Animal Science/Veterinary Medicine Bldg, 1988 Fitch Ave, St. Paul, MN 55108, USA.
   Vascular Biology Center, Division of Hematology, Oncology &Transplantation, Department of Medicine, University of Minnesota, 14-100 PWB, 516 Delaware ST SE,Minneapolis, MN 55455, USA.
NR 0
TC 0
SN 2045-232
EI 
J9 Sci Rep
PD OCT 1
PY 2016
VL 6
IS 
BP 34493
EP 34493
DI 10.1038/srep34493 
PG 0
UT PubMed:27687125
PM 27687125
DA 2016-10-01
ER

PT J
AU Noor, MT
   Vaiphei, K
   Nagi, B
   Singh, K
   Kochhar, R
AF Noor, Mohd Talha
   Vaiphei, Kim
   Nagi, Birinder
   Singh, Kartar
   Kochhar, Rakesh
TI Role of needle knife assisted ampullary biopsy in the diagnosis of periampullary 
SO World journal of gastrointestinal endoscopy
LA English
DT Journal Article
DE Carcinoma; Endoscopic ultrasound; Endoscopy; Needle knife; Papillotomy; Periampullary
AB AIM: To study the role of needle knife assisted ampullary biopsy in the diagnosis 
   of periampullary carcinoma. METHODS: In this study the authors retrospectively 
   analyzed clinical records of patients with periampullary tumors diagnosed by 
   ampullary biopsy taken after needle knife papillotomy in whom surface ampullary 
   biopsies were non contributory. RESULTS: Between January 2008 and December 2010, 
   38 patients with periampullary tumors were seen by us and initial side viewing 
   endoscopy with surface biopsy from the papilla was positive for malignancy in 25 
   patients. Thirteen patients with a negative surface biopsy for malignancy 
   underwent a repeat ampullary biopsy following needle knife papillotomy. There 
   were 8 (61.5%) males and 5 (38.5%) females. The most common presenting symptom 
   was jaundice (100%), followed by fever (46.2%), melena (38.5%), abdominal pain 
   (30.8%) and weight loss (30.8%). All the patients had hyperbilirubinemia with a 
   mean ± SD serum bilirubin of (11.2 ± 1.9) mg/dL (normal value < 1 mg%) and the 
   mean ± SD serum alkaline phosphatase was (288.0 ± 94.3) IU/L (normal value < 129 
   IU/L). Serum CA 19.9 level estimation was done in 11 patients; it was elevated 
   (cut off value > 70.5 IU/L) in all of them with a median of 1200 IU/L (inter 
   quartile range 274-3500). Side viewing endoscopy showed a bulky papilla in all of 
   them. Adequate tissue was obtained in all of the 13 patients for histological 
   evaluation; 12 of the 13 patients were reported to have adenocarcinoma while one 
   patient had adenoma. There were no complications from the needle knife 
   papillotomy in any of the patients. CONCLUSION: Needle knife assisted ampullary 
   biopsy appears to be a safe and effective diagnostic modality for periampullary 
   carcinoma.
C1 Mohd Talha Noor, Kim Vaiphei, Birinder Nagi, Kartar Singh, Rakesh Kochhar, Department of Gastroenterology, Postgraduate Institute of Medical Education andResearch, Sector 12, Chandigarh 160012, India.
NR 0
TC 0
SN 1948-519
EI 1948-519
J9 World J Gastrointest Endosc
PD NOV 24
PY 2011
VL 3
IS 11
BP 220
EP 4
DI 10.4253/wjge.v3.i11.220 
PG -216
UT PubMed:22110838
PM 22110838
DA 2011-11-24
ER

PT J
AU Masuyama, S
   Yamashita, H
   Amino, T
   Kawamoto, R
   Tsuji, R
   Nakanishi, H
   Yoshida, H
AF Masuyama, Shoko
   Yamashita, Hitoshi
   Amino, Tamami
   Kawamoto, Ryouko
   Tsuji, Ryota
   Nakanishi, Hiromoto
   Yoshida, Hiroshi
TI Acupuncture for patients with Cancer in a Japanese palliative care team: A 
SO Integrative medicine research
LA English
DT Journal Article
DE Acupuncture; Cancer patient; Case series; Japan; Palliative care
AB BACKGROUND: The joint guidelines of the Society for Integrative Oncology and the 
   American Society of Clinical Oncology recommend acupuncture for pain symptoms in 
   some patients with cancer. This study assessed whether adding acupuncture to 
   usual palliative care alleviates the subjective symptoms of hospitalized patients 
   with cancer in Japan, at least in the short term. METHODS: Between 2015 and 2019, 
   we conducted a prospective case series study at a regional core hospital in 
   Osaka. Acupuncture was included in the usual care of patients with cancer. The 
   primary outcome was immediate changes in each patient's subjective symptoms 
   measured by a 10 cm visual analog scale (VAS). A 20 % reduction in VAS was set as 
   the minimal clinically important difference (MCID). RESULTS: A total of 83 cancer 
   patients (mean age: 66.1) were treated with acupuncture. A significant reduction 
   was observed in the VAS scores for pain, edema, nausea, neck/shoulder/back 
   stiffness, and breathlessness during at least one treatment session. The 
   percentage of patients that improved beyond the MCID was as follows: 67 % for 
   pain, 75 % for edema, 60 % for paresthesia, 80 % for nausea, 88 % for stiffness, 
   38 % for malaise, and 83 % for breathlessness, based on the maximum improvement 
   recorded per session. CONCLUSION: Japanese-style acupuncture, with relatively 
   finer needles and gentler stimulation, has shown promise as a palliative 
   treatment for patients with cancer, potentially offering temporary relief from 
   pain, edema, nausea, stiffness, and breathlessness. Based on our findings, a 
   pragmatic randomized controlled trial with an appropriate control group is 
   recommended.
C1 Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan.
   Department of Acupuncture, Morinomiya University of Medical Sciences, Osaka, 
   Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan.
   Department of Acupuncture, Morinomiya University of Medical Sciences, Osaka, 
   Osaka General Medical Center, Osaka, Japan.
   Osaka General Medical Center, Osaka, Japan.
   Department of Acupuncture, Morinomiya University of Medical Sciences, Osaka, Japan.
   Department of Acupuncture, Morinomiya University of Medical Sciences, Osaka, Japan.
   Osaka General Medical Center, Osaka, Japan.
NR 0
TC 0
SN 2213-423
EI 2213-422
J9 Integr Med Res
PD SEP 11
PY 2025
VL 15
IS 1
BP 101212
EP 101212
DI 10.1016/j.imr.2025.101212 
PG 0
UT PubMed:40933787
PM 40933787
DA 2025-09-11
ER

PT J
AU Dan-Feng, Z
   Jian-Cheng, R
   Shu-Zhen, Z
   Kun, Z
   Hong-Zhi, Y
   Lian-Sheng, Y
   Chun-Zhi, T
AF Dan-Feng, Zhou
   Jian-Cheng, Rong
   Shu-Zhen, Zheng
   Kun, Zhang
   Hong-Zhi, Yang
   Lian-Sheng, Yang
   Chun-Zhi, Tang
TI Enhanced acupuncture therapy for radiotherapy-related neuropathic pain in 
SO Frontiers in neurology
LA English
DT Journal Article
DE acupuncture; cancer; case report; neuropathic pain; radiotherapy
AB As radiation therapy is increasingly utilized in the treatment of cancer, 
   neuropathic pain (NP) is a common radiotherapy-related adverse effect and has a 
   significant impact on clinical outcomes negatively. However, despite an improved 
   understanding of neuropathic pain management, pain is often undertreated in 
   patients with cancer. Herein, we reported two cases with radiotherapy-related 
   neuropathic pain (RRNP) who presented a positive reaction to acupuncture. Patient 
   1 (a 73-year-old woman) with gynecologic cancer complained of burning and 
   electric shock-like pain in the lower limb after radiotherapy. With the accepted 
   combination of acupuncture and drugs, the pain was alleviated completely in 8 
   weeks. Patient 2 (a 64-year-old woman) accepted acupuncture in the absence of 
   medication because of her inability to tolerate the adverse events of 
   anticonvulsant drugs. She achieved remission of pain 4 weeks later. The results 
   of this study showed that acupuncture might be promising for controlling the RRNP 
   in patients with cancer, especially who were intolerant or unresponsive to 
   medications.
C1 Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
   Department of Rehabilitation, Jiangmen Central Hospital, Jiangmen, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
   Department of Traditional Chinese Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
   Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese 
   South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou,China.
NR 0
TC 0
SN 1664-229
EI 1664-229
J9 Front Neurol
PD JUN 23
PY 2023
VL 14
IS 
BP 1163990
EP 1163990
DI 10.3389/fneur.2023.1163990 
PG 0
UT PubMed:37351267
PM 37351267
DA 2023-06-23
ER

PT J
AU Hu, C
   Zhang, H
   Wu, W
   Yu, W
   Li, Y
   Bai, J
   Luo, B
   Li, S
AF Hu, Caiqiong
   Zhang, Haibo
   Wu, Wanyin
   Yu, Weiqing
   Li, Yong
   Bai, Jianping
   Luo, Baohua
   Li, Shuping
TI Acupuncture for Pain Management in Cancer: A Systematic Review and Meta-Analysis.
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Review
AB Objective. To evaluate the effectiveness and safety of acupuncture for 
   cancer-related pain. Methods. A systematic review of literatures published from 
   database inception to February 2015 was conducted in eight databases. RCTs 
   involving acupuncture for treatment of cancer-related pain were identified. Two 
   researchers independently performed article selection, data extraction, and 
   quality assessment of data. Results. 1,639 participants in twenty RCTs were 
   analyzed. All selected RCTs were associated with high risk of bias. Meta-analysis 
   indicated that acupuncture alone did not have superior pain-relieving effects as 
   compared with conventional drug therapy. However, as compared with the drug 
   therapy alone, acupuncture plus drug therapy resulted in increased pain remission 
   rate, shorter onset time of pain relief, longer pain-free duration, and better 
   quality of life without serious adverse effects. However, GRADE analysis revealed 
   that the quality of all outcomes about acupuncture plus drug therapy was very 
   low. Conclusions. Acupuncture plus drug therapy is more effective than 
   conventional drug therapy alone for cancer-related pain. However, multicenter 
   high-quality RCTs with larger sample sizes are needed to provide stronger 
   evidence for the effectiveness of acupuncture in cancer-related pain due to the 
   low data quality of the studies included in the current meta-analysis.
C1 The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
   Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
   Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
   The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
   Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
   Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
   The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
   The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD MAR 16
PY 2016
VL 2016
IS 
BP 1720239
EP 1720239
DI 10.1155/2016/1720239 
PG 0
UT PubMed:26977172
PM 26977172
DA 2016-03-16
ER

PT J
AU Lu, T
   Zhang, J
   Lv, Y
   Wu, Y
AF Lu, Tianchen
   Zhang, Junfeng
   Lv, Ying
   Wu, Yaochi
TI The effect of warm needle moxibustion on lumbar disc herniation.
SO American journal of translational research
LA English
DT Journal Article
DE Warm needle moxibustion; lumbar disc herniation; therapeutic effect
AB OBJECTIVE: To investigate the effect of warm needle moxibustion on patients with 
   lumbar disc herniation (LDH). METHODS: A total of 100 patients with lumbar disc 
   herniation treated in our hospital were recruited as the study cohort and 
   randomly assigned into a control group and an observation group. The patients in 
   the control group underwent routine acupuncture treatment, while those in the 
   observation group underwent warm needle moxibustion treatment. The observed 
   indexes, including the clinical efficacy, the visual analogue scale (VAS) scores, 
   the Japanese Orthopedic Association (JOA) scores, the Oswestry disability index 
   (ODI) scores, and the serum inflammatory factor levels were compared between the 
   control group and the observation group. RESULTS: The total cure rate in the 
   observation group was significantly higher than it was in the control group 
   (76.0% vs 92%, P=0.029). Compared with the patients in the control group after 
   the treatment, the patients' VAS and ODI scores in the observation group were 
   significantly lower, but their JOA scores were significantly higher, and the 
   differences were statistically significant (all P<0.001). Moreover, the serum 
   IL-6 and tumor necrosis factor α (TNF-α) levels in the observation group were 
   remarkably lower than the corresponding levels in the control group (all 
   P<0.001). CONCLUSIONS: Warm needle moxibustion has a significant effect on 
   patients with lumbar disc herniation, because it helps to relieve the pain and 
   other symptoms and reduces the serum inflammatory factor levels.
C1 Department of Acupuncture and Massage, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shanghai, China.
   Department of Acupuncture and Massage, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shanghai, China.
   Department of Acupuncture and Massage, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shanghai, China.
   Department of Acupuncture and Massage, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shanghai, China.
NR 0
TC 0
SN 1943-814
EI 1943-814
J9 Am J Transl Res
PD JUN 22
PY 2021
VL 13
IS 5
BP 5059
EP 5065
DI 
PG 6
UT PubMed:34150092
PM 34150092
DA 2021-06-22
ER

PT J
AU Robinson, CL
   Berger, A
   Sottosanti, E
   Li, M
   Kaneb, A
   Keefe, J
   Kim, E
   Kaye, AD
   Viswanath, O
   Urits, I
AF Robinson, Christopher L
   Berger, Amnon
   Sottosanti, Emily
   Li, Michael
   Kaneb, Alicia
   Keefe, Joseph
   Kim, Edward
   Kaye, Alan D
   Viswanath, Omar
   Urits, Ivan
TI Acupuncture as Part of Multimodal Analgesia for Chronic Pain.
SO Orthopedic reviews
LA English
DT Journal Article
DE Acupuncture; Cancer; Chronic Abdominal Pain; Comprehensive Medicine; Neck Pain
AB BACKGROUND: Chronic pain is a multifactorial condition that is afflicting 
   populations worldwide causing an increasing economic, physical, mental, and 
   emotional burden. Treatments range from medications to interventional procedures 
   to complementary and alternative medicine (CAM), such as acupuncture. This review 
   aims to discuss the use of acupuncture in the treatment of chronic pain, proposed 
   mechanisms, indications, and efficacy for various chronic pain conditions. 
   RESULTS: Evidence is varied on the efficacy and quality of data on the use of 
   acupuncture in the treatment of chronic pain. Recent studies have demonstrated 
   promising results in the support of acupuncture for the use in the treatment of 
   cancer, neck, and back pain, functional dyspepsia, and various chronic abdominal 
   pain syndromes. CONCLUSION: Acupuncture, deemed well-tolerated and safe to use, 
   has been increasingly studied and is regarded as effective in clinical practice, 
   but its efficacy is limited by the lack of well-conducted, high-quality clinical 
   trials, lower quality evidence, and conflicting study results. Additionally, the 
   exact analgesic mechanism of acupuncture remains to be fully elucidated. 
   Increasing evidence supports the role of acupuncture as therapy in the treatment 
   of cancer, neck, and back pain and functional dyspepsia. Further rigorous studies 
   are needed to fully assess the use of acupuncture in various chronic pain 
   conditions, determine its indications, and optimal treatment schedule. Overall, 
   future studies could benefit from better designed experimental studies, larger 
   groups, and more objectives ways to measure pain reduction and symptom 
   improvement.
C1 Anesthesiology, BIDMC.
   Anesthesiology, BIDMC.
   Anesthesiology, BIDMC.
   Anesthesiology, BIDMC.
   Anesthesiology, BIDMC.
   Anesthesiology, BIDMC.
   Anesthesiology, BIDMC.
   Anesthesiology, BIDMC.
   Anesthesiology, BIDMC.
   Anesthesiology, BIDMC.
NR 0
TC 0
SN 2035-816
EI 2035-823
J9 Orthop Rev (Pavia)
PD SEP 29
PY 2022
VL 14
IS 3
BP 38321
EP 38321
DI 10.52965/001c.38321 
PG 0
UT PubMed:36168395
PM 36168395
DA 2022-09-29
ER

PT J
AU Lahoud, MJ
   Kourie, HR
   Antoun, J
   El, Osta L
   Ghosn, M
AF Lahoud, Marie José
   Kourie, Hampig Raphael
   Antoun, Joelle
   El Osta, Lana
   Ghosn, Marwan
TI Road map for pain management in pancreatic cancer: A review.
SO World journal of gastrointestinal oncology
LA English
DT Review
DE Interventional; Medical; Pain management; Pancreatic cancer; Treatment
AB Beside its poor prognosis and its late diagnosis, pancreatic cancer remains one 
   of the most painful malignancies. Optimal management of pain in this cancer 
   represents a real challenge for the oncologist whose objective is to ensure a 
   better quality of life to his patients. We aimed in this paper to review all the 
   treatment modalities incriminated in the management of pain in pancreatic cancer 
   going from painkillers, chemotherapy, radiation therapy and interventional 
   techniques to agents under investigation and alternative medicine. Although 
   specific guidelines and recommendations for pain management in pancreatic cancer 
   are still absent, we present all the possible pain treatments, with a progression 
   from medical multimodal treatment to radiotherapy and chemotherapy then 
   interventional techniques in case of resistance. In addition, alternative methods 
   such as acupuncture and hypnosis can be added at any stage and seems to 
   contribute to pain relief.
C1 Marie José Lahoud, Department of Anesthesiology and Critical Care, Faculty of Medicine, Saint Joseph University, Beirut 166830, Lebanon.
   Marie José Lahoud, Department of Anesthesiology and Critical Care, Faculty of Medicine, Saint Joseph University, Beirut 166830, Lebanon.
   Marie José Lahoud, Department of Anesthesiology and Critical Care, Faculty of Medicine, Saint Joseph University, Beirut 166830, Lebanon.
   Marie José Lahoud, Department of Anesthesiology and Critical Care, Faculty of Medicine, Saint Joseph University, Beirut 166830, Lebanon.
   Marie José Lahoud, Department of Anesthesiology and Critical Care, Faculty of Medicine, Saint Joseph University, Beirut 166830, Lebanon.
NR 0
TC 0
SN 1948-520
EI 1948-520
J9 World J Gastrointest Oncol
PD AUG 31
PY 2016
VL 8
IS 8
BP 599
EP 606
DI 10.4251/wjgo.v8.i8.599 
PG 7
UT PubMed:27574552
PM 27574552
DA 2016-08-31
ER

PT J
AU Liao, C
   Tao, S
   Xiong, Y
   Dai, J
   Bai, Y
   Wang, X
   Li, Y
   Wu, P
AF Liao, Chenxi
   Tao, Siyu
   Xiong, Yan
   Dai, Jingyang
   Bai, Yu
   Wang, Xue
   Li, Yuan
   Wu, Ping
TI The Effects and Potential Mechanisms of Moxibustion for Rheumatoid 
SO Journal of pain research
LA English
DT Journal Article
DE inflammatory factor; moxibustion; pain; rheumatoid arthritis
AB PURPOSE: To investigate the effects of moxibustion in relieving pain, and other 
   clinical symptoms for patients with rheumatoid arthritis (RA), and explore the 
   potential mechanism of moxibustion treatment for RA. PATIENTS AND METHODS: 
   Seventy qualified RA patients were randomly assigned in a 1:1 ratio to the 
   moxibustion group or the routine group. The routine group only took oral 
   methotrexate tablets and folic acid tablets. The moxibustion group was treated 
   with moxibustion based on oral pharmaceutical. Moxibustion was performed two 
   times weekly for 8 weeks, a total of 16 sessions. Patients scored their pain on a 
   visual analog scale (VAS). The American College of Rheumatology improvement 
   criteria of 20%, 50% and 70% (ACR20, ACR50 and ACR70) after treatment were 
   investigated. Clinical symptoms, a disease activity score using 28 joint counts 
   (DAS28), simplified disease activity index (SDAI), clinical disease activity 
   index (CDAI), health assessment questionnaire (HAQ), interleukin 1β (IL-1β), 
   tumor necrosis factor-alpha (TNF-α), and vascular endothelial growth factor 
   (VEGF) of RA patients were analyzed before and after treatment. RESULTS: After 
   treatment, the VAS scores, tender and swollen joint counts, morning stiffness 
   scores, disease activity scores (DAS28, SDAI, CDAI), HAQ scores in the two groups 
   were both improved, and the effects of moxibustion group were more obvious (P < 
   0.05). The ACR20 and ACR50 of the moxibustion group were greater than that of the 
   routine group (P < 0.05), no significant difference of the ACR70 existed between 
   the two groups (P > 0.05). In addition, the decreases of IL-1β, TNF-α, VEGF of 
   the moxibustion group were better than that of the routine group (P < 0.05). 
   CONCLUSION: Moxibustion could effectively relieve pain, ameliorate the clinical 
   symptoms, and decrease the disease activity of RA. The potential mechanism may be 
   the decrease in the level of serum inflammatory factors.
C1 Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
   Department of Osteoporosis, Huaxi Fourth Hospital, Sichuan University, Chengdu, People's Republic of China.
   Department of Traditional Chinese Medicine, Chengdu Fifth People's Hospital, Chengdu, People's Republic of China.
   Department of Traditional Chinese Medicine, Chengdu Second People's Hospital, Chengdu, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
   Department of Rheumatology, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD JUN 1
PY 2023
VL 16
IS 
BP 1739
EP 1749
DI 10.2147/JPR.S408814 
PG 10
UT PubMed:37261035
PM 37261035
DA 2023-06-01
ER

PT J
AU Lee, MS
   Kang, JW
   Ernst, E
AF Lee, Myeong Soo
   Kang, Jung Won
   Ernst, Edzard
TI Does moxibustion work? An overview of systematic reviews.
SO BMC research notes
LA English
DT Journal Article
AB BACKGROUND: Several systematic reviews (SRs) have assessed the effectiveness of 
   moxibustion for a range of conditions, often with contradictory conclusions. Our 
   aim was to provide a critical evaluation and summary of these data. METHODS: 
   Electronic searches were conducted to locate all SRs of moxibustion for any 
   condition. Data were extracted by two authors according to predefined criteria. 
   RESULTS: Ten SRs met our inclusion criteria, which related to the following 
   conditions: cancer, ulcerative colitis, stroke rehabilitation, constipation, 
   hypertension, pain conditions and breech presentation. Their conclusions were 
   contradictory in several instances. Relatively clear evidence emerged to suggest 
   that moxibustion is effective for breech presentation. CONCLUSIONS: Based on 
   evidence from the currently available SRs, the effectiveness of moxibustion has 
   been demonstrated for several conditions; however, due to the poor quality of the 
   primary studies, there remains considerable uncertainty.
C1 Policy Division, Korea Institute of Oriental Medicine, Daejeon, South Korea. drmslee@gmail.com.
NR 0
TC 0
SN 1756-050
EI 
J9 BMC Res Notes
PD NOV 9
PY 2010
VL 3
IS 
BP 284
EP 284
DI 10.1186/1756-0500-3-284 
PG 0
UT PubMed:21054851
PM 21054851
DA 2010-11-09
ER

PT J
AU Saraswati, W
   Dahlan, EG
   Saputra, K
   Sutrisno, TC
AF Saraswati, Wita
   Dahlan, Erry Gumilar
   Saputra, Koosnadi
   Sutrisno, Thomas Cahyono
TI Effect of Electroacupuncture on Natural-Killer Cells and Tumor Size in Patients 
SO Medical acupuncture
LA English
DT Journal Article
DE cervical squamous-cell carcinoma; electroacupuncture; natural-killer cells
AB Background: A natural-killer (NK) cell is a cytotoxic lymphocyte that responds to 
   tumor formation. Electroacupuncture (EA) in patients with cancer, who had 
   chemotherapy, enabled them to maintain their T-cell counts (CD3+, CD4+, and CD8+) 
   and NK-cell activity. Objective: To evaluate NK-cell levels and tumor sizes in 
   patients with cervical squamous-cell carcinoma (SCC) after EA on ST 36 (Zusanli). 
   Design: This study was a randomized, experimental clinical study with a 
   pre-post-test, control group design. Setting The study was performed in the 
   obstetrics and gynecology department, Gynecology Oncology Division of the Rumah 
   Sakit Dokter Soetomo General Hospital, in Surabaya, Jawa Timur, Indonesia, 
   conducted from February 2016 until May 2016. Subjects: Patients with cervical 
   SCC, stages IIb-IIIb (locally advanced)-determined clinically and 
   histopathologically-all of whom had 50 mg/m(2)/week of cisplatin chemotherapy. 
   The patients were divided, consecutively, into 2 groups by simple random 
   sampling. Intervention: The controls received only received the chemotherapy, 
   while treatment-group patients also had EA 1 day on bilateral ST 36 after each 
   chemotherapy cycle. Outcome Measures: Primary outcomes were percent of NK cells 
   and tumor size. Before the first treatment and after the fourth one, all patients 
   underwent peripheral blood examinations (complete blood counts, serum creatinine 
   and blood-urea-nitrogen levels, and flow-cytometry) to determine percentages of 
   NK cells, and pelvic magnetic resonance imaging to measure cervical tumor sizes. 
   Secondary outcomes were pain, nausea, vomiting, and appetite. Results: There was 
   a significant increase in number of NK cells (P = 0.00) and a significant 
   decrease in tumor sizes (P = 0.03) in the treatment group, compared to the 
   control group. There was a significant increase in appetite (P = 0.00) in the 
   treatment group, compared to baseline, but there were no significant differences 
   in pain (P = 0.061), nausea (P = 0.399), and vomiting (P = 0.854). Conclusions: 
   Patients with cervical SCC at stages IIb-IIIb, who received 4 cycles of 
   chemotherapy using 50 mg/m(2)/week of cisplatin and EA at ST 36, had increased 
   NK-cell percentages in their peripheral blood and had reductions in their 
   cervical tumors.
C1 Obstetrics and Gynecologic Department, Rumah Sakit Dokter Soetomo General Hospital, Surabaya, Jawa Timur, Indonesia.
   Faculty of Medicine, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia.
   Obstetrics and Gynecologic Department, Rumah Sakit Dokter Soetomo General Hospital, Surabaya, Jawa Timur, Indonesia.
   Faculty of Medicine, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia.
   Acupuncture Research Laboratory in Health Services, Ministry of Health of the Republic of Indonesia, Surabaya, Jawa Timur, Indonesia.
   Academy of Acupuncture Surabaya, Jawa Timur, Indonesia.
   Academy of Acupuncture Surabaya, Jawa Timur, Indonesia.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD FEB 26
PY 2019
VL 31
IS 1
BP 29
EP 36
DI 10.1089/acu.2018.1316 
PG 7
UT PubMed:30805077
PM 30805077
DA 2019-02-26
ER

PT J
AU Kilian-Kita, A
   Puskulluoglu, M
   Konopka, K
   Krzemieniecki, K
AF Kilian-Kita, Aneta
   Puskulluoglu, Mirosława
   Konopka, Kamil
   Krzemieniecki, Krzysztof
TI Acupuncture: could it become everyday practice in oncology?
SO Contemporary oncology (Poznan, Poland)
LA English
DT Review
DE acupuncture; cancer; complementary and alternative treatment; side effects; supportive treatment
AB Acupuncture is a complementary and alternative medical treatment (CAM) which is 
   increasingly used in the care of cancer patients. Traditionally derived from 
   Chinese medicine, nowadays it is becoming a part of evidence-based oncology. The 
   use of acupuncture in these patients has been recommended by the American Cancer 
   Society (ACS) for the treatment of side effects associated with conventional 
   cancer therapy and cancer-related ailments. A growing body of evidence supports 
   the use of acupuncture in the treatment of cancer-induced pain and 
   chemotherapy-related nausea and vomiting. Also other indications, such as 
   xerostomia, fatigue, hot flashes, anxiety and peripheral neuropathy, are being 
   constantly evaluated. This article summarizes the most important discoveries 
   related to the possible usefulness of this method in contemporary oncology. 
   Emphasis is placed on the results of randomized controlled trials with an 
   adequate level of evidence. However, explanation of the mechanisms responsible 
   for these effects requires confirmation in further studies with an adequate level 
   of evidence. In future, acupuncture may become an interesting and valuable 
   addition to conventional medicine.
C1 Department of Clinical Oncology, University Hospital in Krakow, Krakow, Poland.
   Department of Clinical Oncology, University Hospital in Krakow, Krakow, Poland.
   Department of Clinical Oncology, University Hospital in Krakow, Krakow, Poland.
   Department of Clinical Oncology, University Hospital in Krakow, Krakow, Poland.
NR 0
TC 0
SN 1897-430
EI 1428-252
J9 Contemp Oncol (Pozn)
PD JUL 1
PY 2016
VL 20
IS 2
BP 119
EP 23
DI 10.5114/wo.2016.60065 
PG -96
UT PubMed:27358589
PM 27358589
DA 2016-07-01
ER

PT J
AU Ben-Arye, E
   Vagedes, J
   Kassem, S
   Samuels, N
   Lavie, O
   Zaritsky, V
   Gressel, O
AF Ben-Arye, Eran
   Vagedes, Jan
   Kassem, Sameer
   Samuels, Noah
   Lavie, Ofer
   Zaritsky, Vika
   Gressel, Orit
TI Adding Acupuncture to Touch/Relaxation for Pain in Wartime: A Randomized 
SO Journal of pain and symptom management
LA English
DT Journal Article
DE Integrative oncology; acupuncture; cancer; heart rate variability; integrative medicine
AB CONTEXT AND OBJECTIVES: Patients with cancer living in war zones face significant 
   quality of life (QoL)-related challenges. This study examined an integrative 
   oncology (IO) intervention in northern Israel for pain and autonomic response. 
   METHODS: This prospective, randomized, controlled and pragmatic study examined an 
   IO intervention with manual-relaxation, with acupuncture (Group A) or without 
   (Group B). ESAS (Edmonton Symptom Assessment Scale), EORTC QLQ-C30 (European 
   Organization for Research and Treatment of Cancer QoL Questionnaire), and MYCAW 
   (Measure Yourself Concerns and Wellbeing) tools were used to examine QoL. Heart 
   rate and variability (HRV) were measured at baseline and 15 minutes 
   post-treatment, comparing frequency-domain variable changes (e.g., LN Power 
   Total, Power HF, Power LF, Power VLF). RESULTS: Of 125 patients, Groups A (67) 
   and B (58) had similar demographic and cancer-related characteristics. ESAS pain 
   scores improved in both groups post-treatment (A, P < 0.001; B, P = 0.002), as 
   did anxiety, depression, and fatigue. At three weeks, Group B reported greater 
   improvement on ESAS pain (P = 0.039) and MYCAW pain-related concerns (P = 0.025), 
   both showing within-group improvement on EORTC pain. HRV showed greater change in 
   Group A, with decreased LN Power Total (P = 0.006), LN Power LF (P = 0.02), and 
   LN Power VLF (P = 0.026). While Relative Power HF increased marginally (P = 
   0.054), heart rate decreasing more significantly in Group B (P = 0.005). 
   CONCLUSIONS: IO treatments led to reduced pain among patients with cancer living 
   in a war zone, with no additive effect of acupuncture. HRV changes suggest 
   enhanced parasympathetic activity, with acupuncture-treated patients showing 
   additional frequency-domain changes attributed to decreased sympathetic tone.
C1 Ruth and Bruce Rappaport Faculty of Medicine (E.B.A., S.K., O.L., V.Z., O.G.), Technion-Israel Institute of Technology, Haifa, Israel
   Integrative OncologyProgram, The Oncology Service (E.B.A., O.G.), Lin, Carmel, and Zebulun Medicalcenters, Clalit Health Services, Haifa, Israel. 
   ARCIM Institute (J.V.), Research Institute, Filderstadt, Germany
   Department of Neonatology (J.V.), University Hospital Tuebingen, University Tuebingen,Tuebingen, Germany.
   Ruth and Bruce Rappaport Faculty of Medicine (E.B.A., S.K., O.L., V.Z., O.G.), Technion-Israel Institute of Technology, Haifa, Israel
   Department of InternalMedicine (S.K.), Lady Davis Carmel Medical Center, Haifa, Israel.
   Center for Integrative Complementary Medicine (N.S.), Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
   Ruth and Bruce Rappaport Faculty of Medicine (E.B.A., S.K., O.L., V.Z., O.G.), Technion-Israel Institute of Technology, Haifa, Israel
   Unit of GynecologicOncology (O.L.), Department of Obstetrics and Gynecology, Carmel Medical Center,Haifa, Israel.
   Ruth and Bruce Rappaport Faculty of Medicine (E.B.A., S.K., O.L., V.Z., O.G.), Technion-Israel Institute of Technology, Haifa, Israel.
   Ruth and Bruce Rappaport Faculty of Medicine (E.B.A., S.K., O.L., V.Z., O.G.), Technion-Israel Institute of Technology, Haifa, Israel
   Integrative OncologyProgram, The Oncology Service (E.B.A., O.G.), Lin, Carmel, and Zebulun Medicalcenters, Clalit Health Services, Haifa, Israel.
EM ranben@technion.ac.il
NR 0
TC 0
SN 1873-651
EI 
J9 J Pain Symptom Manage
PD DEC 12
PY 2025
VL 0
IS 
BP 
EP 
DI 10.1016/j.jpainsymman.2025.12.001 
PG 0
UT PubMed:41380985
PM 41380985
DA 2025-12-12
ER

PT J
AU Deng, G
AF Deng, Gary
TI Acupuncture As a Potential Opioid-Sparing Pain Management Intervention for 
SO Medical acupuncture
LA English
DT Journal Article
DE acupuncture; chemotherapy; opioids; pain; symptom management
AB Background: High-symptom burdens, including pain, are associated with high-dose 
   chemotherapy. Objective: We conducted a pilot study to evaluate how acupuncture 
   may affect symptom burden and use of pain medication. Design: This is a 
   randomized sham acupuncture (SA) controlled trial. Setting: An academic cancer 
   center. Patients: Patients were with multiple myeloma undergoing autologous 
   hematopoietic stem cell transplantation. Intervention: Once daily acupuncture for 
   5 days after high-dose chemotherapy. Main Outcome Measures: M. D. Anderson 
   Symptom Inventory (MDASI), opioid use. Results: Compared with SA, true 
   acupuncture reduced nausea, poor appetite, and drowsiness, and use of opioids in 
   opioid-naive patients. Randomizations: Yes. Blinding: Investigators and study 
   participants were blinded. Conclusion: Further study of acupuncture in a larger 
   trial is warranted for its effect on reducing opioid use and symptom burdens 
   during high-dose chemotherapy. Registration: NCT01811862.
C1 Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD DEC 29
PY 2020
VL 32
IS 6
BP 394
EP 395
DI 10.1089/acu.2020.1494 
PG 1
UT PubMed:33362896
PM 33362896
DA 2020-12-29
ER

PT J
AU Li, H
   Doorenbos, AZ
   Xia, Y
   Sun, J
   Choi, H
   Harris, RE
   Gao, S
   Sullivan, K
   Schlaeger, JM
AF Li, Hongjin
   Doorenbos, Ardith Z
   Xia, Yinglin
   Sun, Jun
   Choi, Hannah
   Harris, Richard E
   Gao, Shuang
   Sullivan, Katy
   Schlaeger, Judith M
TI Using Serum Metabolomic Signatures to Investigate Effects of Acupuncture on 
SO Metabolites
LA English
DT Journal Article
DE acupuncture; breast cancer; fatigue; metabolomics; pain; psychoneurological symptom cluster; sleep disturbance
AB BACKGROUND/OBJECTIVES: Acupuncture is an efficacious integrative therapy for 
   treating pain, fatigue, and sleep disturbance (the psychoneurological symptom 
   cluster) in breast cancer survivors. However, the mechanisms underlying its 
   effects remain unclear, and related metabolomics studies are limited. This study 
   aimed to examine serum metabolite changes after acupuncture and their 
   relationships to symptom improvement. METHODS: Forty-two breast cancer survivors 
   experiencing pain, fatigue, and sleep disturbance participated in a single-arm 
   acupuncture trial. They received a 10-session acupuncture intervention over 5 
   weeks. Fasting blood samples and symptom surveys were collected before and after 
   the acupuncture intervention, and untargeted metabolomics profiling was conducted 
   on serum samples. Mixed-effects models adjusting for covariates (age, race, body 
   mass index, and antidepressant use) were applied for analysis. RESULTS: After 
   acupuncture, there was a significant reduction in the psychoneurological symptom 
   cluster (mean reduction = -6.2, p < 0.001).Bonferroni correction was applied to 
   40 independent metabolite clusters (α = 0.00125); cysteine-glutathione disulfide 
   (p = 0.0006) significantly increased, and retinal (p = 0.0002) and cis-urocanate 
   (p = 0.0005) were significantly decreased. Dimethyl sulfone (p = 0.00139) showed 
   a trend towards reduction after acupuncture and its change (p = 0.04, β =1.97) 
   was positively associated with reduction in the psychoneurological symptom 
   cluster. Also, increased lauroylcarnitine (p = 0.0009) and decreased cytosine (p 
   = 0.0008) can modulate the therapeutic effects of acupuncture. CONCLUSIONS: 
   Acupuncture demonstrates beneficial effects on the psychoneurological symptom 
   cluster in breast cancer survivors. Dimethyl sulfone may be a promising mediator 
   in the relationship between acupuncture and psychoneurological symptoms, while 
   acylcarnitine metabolism may modulate the therapeutic effect of acupuncture.
C1 College of Nursing, University of Illinois Chicago, 845 S. Damen Avenue, Chicago, IL 60612, USA.
   University of Illinois Cancer Center, 818 South Wolcott Ave, Chicago, IL 60612, 
   College of Nursing, University of Illinois Chicago, 845 S. Damen Avenue, Chicago, IL 60612, USA.
   University of Illinois Cancer Center, 818 South Wolcott Ave, Chicago, IL 60612, 
   College of Medicine, University of Illinois Chicago, 1853 W Polk St, Chicago, IL 60612, USA.
   University of Illinois Cancer Center, 818 South Wolcott Ave, Chicago, IL 60612, USA.
   College of Medicine, University of Illinois Chicago, 1853 W Polk St, Chicago, IL 
   College of Nursing, University of Illinois Chicago, 845 S. Damen Avenue, Chicago, IL 60612, USA.
   Susan Samueli Integrative Health Institute, School of Medicine, University of California at Irvine, 856 Health Sciences Rd Suite 2600, Irvine, CA 92617, USA.
   Department of Anesthesia and Perioperative Care, School of Medicine, University 
   College of Medicine, University of Illinois Chicago, 1853 W Polk St, Chicago, IL 60612, USA.
   College of Nursing, University of Illinois Chicago, 845 S. Damen Avenue, Chicago, IL 60612, USA.
   College of Nursing, University of Illinois Chicago, 845 S. Damen Avenue, Chicago, IL 60612, USA.
NR 0
TC 0
SN 2218-198
EI 2218-198
J9 Metabolites
PD DEC 27
PY 2024
VL 14
IS 12
BP 
EP 
DI 10.3390/metabo14120698 
PG 0
UT PubMed:39728478
PM 39728478
DA 2024-12-27
ER

PT J
AU Satija, A
   Bhatnagar, S
AF Satija, Aanchal
   Bhatnagar, Sushma
TI Complementary Therapies for Symptom Management in Cancer Patients.
SO Indian journal of palliative care
LA English
DT Journal Article
DE Cancer; complementary therapies; mind-body therapies; pain; quality of life
AB Cancer patients are often poly-symptomatic which distressingly affects their 
   quality of lives (QOLs). Alhough, conventional management provides adequate 
   symptom control, yet is coupled with some limitations. Complementary therapies 
   (CTs) have shown beneficial effects in cancer patients for symptomatic relief. 
   The aim of this article is to provide evidence-based review of commonly used CTs 
   for symptom management in cancer care. Hypnosis has promising evidence to be used 
   for managing symptoms such as pain, chemotherapy-induced nausea/vomiting, 
   distress, fatigue, and hot flashes. Guided imagery increases comfort and can be 
   used as a psycho-supportive therapy. Meditation substantially improves 
   psychological function, mental health, and QOL. Cognitive behavioral therapies 
   effectively reduce pain, distress, fatigue, anxiety, and depression; and improve 
   subjective sleep outcomes along with mood and QOL. Yoga has short term beneficial 
   effects for anxiety, depression, fatigue, perceived stress, QOL, and well-being. 
   T'ai Chi and qigong are beneficial adjunctive therapies for supportive cancer 
   care, but their role in reducing cancer pain is not well proven. Acupuncture is 
   effective for reducing treatment related side-effects, pain and fatigue. Other 
   therapies such as massage techniques, energy therapies, and spiritual 
   interventions have also demonstrated positive role in managing cancer-related 
   symptoms and improve overall well-being. However, the clinical effectiveness of 
   these therapies for symptom management in cancer patients cannot be concluded due 
   to poor strength of evidence. Nonetheless, these are relatively free from risks 
   and hence can be given along with conventional treatments. Only by tailoring 
   these therapies as per patient's beliefs and preferences, optimal 
   patient-centered holistic care can be provided.
C1 Department of Onco-Anaesthesia and Palliative Medicine, Dr. BRA Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
   Department of Onco-Anaesthesia and Palliative Medicine, Dr. BRA Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
NR 0
TC 0
SN 1998-373
EI 0973-107
J9 Indian J Palliat Care
PD NOV 11
PY 2017
VL 23
IS 4
BP 468
EP 479
DI 10.4103/IJPC.IJPC_100_17 
PG 11
UT PubMed:29123357
PM 29123357
DA 2017-11-11
ER

PT J
AU Zhao, Z
   Li, J
   Wen, J
   He, Y
   Sun, Z
AF Zhao, Zhenni
   Li, Jiawei
   Wen, Jiamin
   He, Yanyan
   Sun, Zhiling
TI Effect of Moxibustion on Inflammatory Cytokines for Low Back Pain: A Systematic 
SO Therapeutics and clinical risk management
LA English
DT Review
DE cytokines; interleukins; low back pain; moxibustion; tumor necrosis factors
AB BACKGROUND AND OBJECTIVE: Moxibustion is effective for low back pain (LBP), and 
   inflammatory cytokines may play an important role in the mechanism of moxibustion 
   treatment. The purpose of this meta-analysis was to explore the mechanism of 
   moxibustion in LBP in terms of inflammatory cytokines. METHODS: We searched China 
   National Knowledge Infrastructure, Wanfang database, Cochrane Central Register of 
   Controlled Trials, Ovid MEDLINE, Embase, PubMed, and Web of Science to identify 
   eligible randomized controlled trials (RCTs). There was no restriction on the 
   publication date. RESULTS: Thirty RCTs measuring interleukin (IL-) 1, IL-1β, 
   IL-6, IL-12, IL-17, IL-23, and tumor necrosis factor (TNF-) α were included in 
   this meta-analysis. Compared to controls: single moxibustion could effectively 
   decrease levels IL-6 and IL-23 (SMD, -0.71, 95% CI: -1.25 to -0.17, p = 0.01; 
   SMD, -1.61, 95% CI: -2.20 to -1.03, p < 0.01, respectively); combined moxibustion 
   had significant effects on IL-1, IL-1β, IL-6, IL-12, IL-17, and TNF-α (p < 0.05). 
   Overall, for LBP, single or combined moxibustion could effectively down-regulate 
   levels of pro-inflammatory cytokines (p = 0.007 and p < 0.00001, respectively). 
   For safety of moxibustion, the incidence rate of side effects was similar to that 
   of controls (RD, -0.01, 95% CI: -0.02 to 0.01, p = 0.59). Sensitivity analysis 
   showed that the pooled estimates were robust, and publication bias analysis 
   showed there was a significant small study effect (Egger's test p = 0.0000). High 
   statistical heterogeneity existed between included RCTs, meta-regression showed 
   there was no potential factor explaining the source of heterogeneity. CONCLUSION: 
   For LBP, moxibustion can effectively decrease levels of IL-1, IL-1β, IL-6, IL-12, 
   IL-17, IL-23, and TNF-α to achieve analgesia. Because the side effects of 
   moxibustion are transient, it is relatively safe for clinical use. However, based 
   on high heterogeneity in this meta-analysis, rigorously designed RCTs are 
   required to further confirm the results in this review.
C1 Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, People's Republic of China.
   School of Nursing, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
   School of Nursing, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
   School of Nursing, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
   School of Nursing, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
NR 0
TC 0
SN 1178-203
EI 1176-633
J9 Ther Clin Risk Manag
PD OCT 24
PY 2023
VL 19
IS 
BP 811
EP 827
DI 10.2147/TCRM.S429469 
PG 16
UT PubMed:37873037
PM 37873037
DA 2023-10-24
ER

PT J
AU Yang, M
   Liou, KT
   Garland, SN
   Bao, T
   Hung, TKW
   Li, SQ
   Li, Y
   Mao, JJ
AF Yang, Mingxiao
   Liou, Kevin T
   Garland, Sheila N
   Bao, Ting
   Hung, Tony K W
   Li, Susan Q
   Li, Yuelin
   Mao, Jun J
TI Acupuncture versus cognitive behavioral therapy for pain among cancer survivors 
SO NPJ breast cancer
LA English
DT Journal Article
AB Pain and insomnia often co-occur and impair the quality of life in cancer 
   survivors. This study evaluated the effect of acupuncture versus cognitive 
   behavioral therapy for insomnia (CBT-I) on pain severity among cancer survivors 
   with comorbid pain and insomnia. Using data from the CHOICE trial that compared 
   acupuncture versus CBT-I for insomnia among cancer survivors, we analyzed the 
   effect of interventions on pain outcomes in 70 patients with moderate to severe 
   baseline pain. Interventions were delivered over eight weeks. We assessed average 
   pain severity (primary outcome) and pain interference at baseline, week 8, and 
   week 20. We further defined insomnia and pain responders as patients who achieved 
   clinically meaningful improvement in insomnia and pain outcomes, respectively, at 
   week 8. We found that compared with baseline, the between-group difference (-1.0, 
   95% CI -1.8 to -0.2) was statistically significant favoring acupuncture for 
   reduced pain severity at week 8 (-1.4, 95% CI -2.0 to -0.8) relative to CBT-I 
   (-0.4, 95% CI-1.0 to 0.2). Responder analysis showed that 1) with acupuncture, 
   insomnia responders reported significantly greater pain reduction from baseline 
   to week 4, compared with insomnia non-responders (-1.5, 95% CI -2.7 to -0.3); 2) 
   with CBT-I, pain responders reported significantly greater insomnia reduction at 
   week 8, compared with pain non-responders (-4.7, 95% CI -8.7 to -1.0). These 
   findings suggest that among cancer survivors with comorbid pain and insomnia, 
   acupuncture led to rapid pain reductions, which contributed to a decrease in 
   insomnia, whereas CBT-I had a delayed effect on pain, possibly achieved by 
   insomnia improvement.
C1 Department of Medicine, Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
   Department of Medicine, Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
   Department of Psychology and Discipline of Oncology, Memorial University, 232 Elizabeth Avenue, St. John's, NL A1B 3×9, Canada.
   Department of Medicine, Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
   Department of Medicine, Division of Solid Tumor Oncology, Head & Neck Oncology Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY,10065, USA.
   Department of Medicine, Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.
   Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
   Department of Medicine, Integrative Medicine Service, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA. maoj@mskcc.org.
NR 0
TC 0
SN 2374-467
EI 2374-467
J9 NPJ Breast Cancer
PD DEC 2
PY 2021
VL 7
IS 1
BP 148
EP 148
DI 10.1038/s41523-021-00355-0 
PG 0
UT PubMed:34848737
PM 34848737
DA 2021-12-02
ER

PT J
AU Wu, HV
   Li, X
   Li, QS
   Baser, RE
   Panageas, KS
   Chimonas, S
   Tap, WD
   Glade, Bender J
   Moskowitz, CS
   Mao, JJ
AF Wu, Han-Wei V
   Li, Xiaotong
   Li, Qing S
   Baser, Raymond E
   Panageas, Katherine S
   Chimonas, Susan
   Tap, William D
   Glade Bender, Julia
   Moskowitz, Chaya S
   Mao, Jun J
TI Effect of Acupuncture and Massage on Pain in Adolescent and Young Adult Patients 
SO Journal of adolescent and young adult oncology
LA English
DT Journal Article
DE health-related quality of life; pain management; quality of life; supportive care
AB Purpose: Pain management remains challenging for adolescent and young adult (AYA) 
   cancer patients. Acupuncture and massage have been recommended for cancer-related 
   pain management, but no prospective trials have been conducted in AYA patients. 
   We explored the effects of acupuncture and massage on pain in AYAs. Methods: This 
   subgroup analysis focused on AYA patients (aged 18-39 years) enrolled in a 
   randomized controlled trial comparing acupuncture and massage for pain management 
   in advanced cancer. Interventions were delivered weekly for 10 weeks, followed by 
   monthly booster treatments through week 26. The primary outcome was the worst 
   pain score from the Brief Pain Inventory, analyzed using a linear mixed-effects 
   model. Results: Thirty participants met eligibility criteria (13 acupuncture; 17 
   massage), with a mean age of 31.1 years (standard deviation, 5.8); 57% were 
   female; 67% were White; and 53% had solid tumors. Both groups experienced reduced 
   pain over time. Relative to baseline, patients receiving acupuncture had a mean 
   change of -1.26 points (95% confidence interval [CI], -2.54 to 0.01) at 10 weeks 
   and a mean change of -1.46 points (95% CI, -2.78 to -0.14) at 26 weeks. Patients 
   receiving massage experienced a mean change of -2.81 points (95% CI, -3.92 to 
   -1.70) at week 10 and a mean change of -3.79 points (95% CI, -4.85 to -2.73) at 
   week 26. Conclusion: AYA patients with advanced cancer who received either 
   acupuncture or massage experienced clinically meaningful and sustained reductions 
   in pain. These findings provide a promising foundation for future trials aimed at 
   evaluating integrative pain management strategies in AYAs.
C1 Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
NR 0
TC 0
SN 2156-535
EI 
J9 J Adolesc Young Adult Oncol
PD AUG 14
PY 2025
VL 0
IS 
BP 
EP 
DI 10.1177/21565333251368891 
PG 0
UT PubMed:40803676
PM 40803676
DA 2025-08-14
ER

PT J
AU Xu, Z
   Wang, X
   Wu, Y
   Wang, C
   Fang, X
AF Xu, Zhonghang
   Wang, Xingbo
   Wu, Yuanyu
   Wang, Chengbing
   Fang, Xuedong
TI The effectiveness and safety of acupuncture for chemotherapy-induced peripheral 
SO Frontiers in neurology
LA English
DT Journal Article
DE acupuncture; chemotherapy-induced peripheral neuropathy; meta-analysis; physiotherapy; systematic review
AB OBJECTIVES: This systematic review and meta-analysis aimed to evaluate the 
   effectiveness and safety of acupuncture on chemotherapy-induced peripheral 
   neuropathy (CIPN). METHODS: We searched for relevant randomized controlled trials 
   (RCTs) in PubMed, Cochrane Library, and Embase databases from their inception to 
   1 April 2022. The Functional Assessment of Cancer Therapy/Gynecologic Oncology 
   Group-Neurotoxicity (FACT/GOG-Ntx), Brief Pain Inventory-Short Form (BPI-SF), the 
   European Organisation for Research and Treatment of Cancer Quality of Life 
   Questionnaire-Core30 (EORTC QLQ-C30), Numerical Rating Scale (NRS), and adverse 
   events were the outcome measures. All studies had at least one of these outcome 
   measures. Mean differences (MDs) with 95% confidence intervals (CIs) were 
   assessed in the meta-analysis using the RevMan 5.3 software. RESULTS: Five 
   studies were included in the analysis. The results showed that acupuncture and 
   placebo acupuncture were not significantly different in reducing 
   chemotherapy-induced neurotoxicity and functional disability (random-effects 
   estimates; MD: 4.30; 95% CI: -0.85~9.45; P = 0.10; I(2) = 74%). Acupuncture was 
   better than placebo acupuncture in reducing pain severity and pain interference 
   with patients' daily function (fixed-effect estimates; MD: -1.14; 95% CI: 1.87 to 
   -0.42; P = 0.002; I(2) = 13%). Acupuncture was not significantly different from 
   placebo acupuncture in relieving CIPN symptoms (MD: -0.81; 95% CI: -2.02 to 0.40, 
   P = 0.19). Acupuncture improved quality of life better than placebo acupuncture 
   (MD: 10.10; 95% CI: 12.34 to 17.86, P = 0.01). No severe adverse events were 
   recorded in all five studies. CONCLUSION: This meta-analysis suggests that 
   acupuncture may be more effective and safer in reducing pain severity and pain 
   interference with patients' daily function than placebo acupuncture. 
   Additionally, acupuncture may improve the quality of life of patients with CIPN. 
   However, large sample size studies are needed to confirm this conclusion. 
   SYSTEMATIC REVIEW REGISTRATION: 
   https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=324930, 
   identifier: CRD42022324930.
C1 China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
   China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
   China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
   China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
   China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
NR 0
TC 0
SN 1664-229
EI 1664-229
J9 Front Neurol
PD OCT 21
PY 2022
VL 13
IS 
BP 963358
EP 963358
DI 10.3389/fneur.2022.963358 
PG 0
UT PubMed:36262831
PM 36262831
DA 2022-10-21
ER

PT J
AU Lyu, C
   Xiao, H
   Yin, X
   Li, Z
   Han, C
   Xu, R
AF Lyu, Chunyi
   Xiao, Hongyan
   Yin, Xuewei
   Li, Zonghong
   Han, Chen
   Xu, Ruirong
TI Acupuncture in Multiple Myeloma Peripheral Neuropathy: A Systematic Review.
SO Journal of pain research
LA English
DT Review
DE acupuncture; multiple myeloma peripheral neuropathy; pain; systematic review
AB BACKGROUND: Peripheral neuropathy (PN) is a prevalent complication of multiple 
   myeloma (MM), due to the disease itself or its treatment. Despite extensive 
   research, the optimal treatment for multiple myeloma peripheral neuropathy (MMPN) 
   remains unclear. Clinical practice has shown the potential efficacy of 
   acupuncture in managing MMPN. This study aimed to conduct a comprehensive 
   analysis of the literature to assess the effectiveness and safety of acupuncture 
   as a treatment for MMPN. METHODS: The PubMed, Web of Science, MEDLINE, Cochrane 
   Library, and Embase databases were comprehensively searched from inception to 
   November 1, 2023 to identify relevant studies pertaining to the use of 
   acupuncture to treat MMPN. RESULTS: A total of five studies, encompassing 97 
   patients diagnosed with drug-related PN, were ultimately included in this 
   analysis. The literature lacks any reports pertaining to the utilization of 
   acupuncture for disease-related PN. ST36, LI4, SP6, and EX-LE-10 were found to be 
   the most frequently chosen acupoints. Following acupuncture treatment, there was 
   a consistent reduction in scores on the Visual Analogue Scale (VAS), Neuropathic 
   Pain Scale (NPS), Brief Pain Inventory-Short Form (BPI-SF), and Functional 
   Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity 
   (FACT/GOG-Ntx) among MMPN patients. The results of Nerve Conduction Velocity 
   (NCV) tests yielded conflicting results. No severe adverse effects were reported. 
   CONCLUSION: The use of acupuncture for disease-related PN has not been studied to 
   date. Acupuncture is safe for drug-related PN and is helpful for relieving pain. 
   But uncertainty exists regarding the efficacy of this approach because there is 
   substantial heterogeneity with respect to acupuncture treatment regimens, and 
   more high-quality studies on this topic are warranted.
C1 First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250014, People's Republic of China.
   First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250014, People's Republic of China.
   Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250002, People's Republic of China.
   First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250014, People's Republic of China.
   First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250014, People's Republic of China.
   Key Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, Health Commission of Shandong Province
   Institute of Hematology,Shandong University of Traditional Chinese Medicine, Jinan, 250014, People'sRepublic of China.
   Department of Hematology, Affiliated Hospital of Shandong University of 
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD MAY 3
PY 2024
VL 17
IS 
BP 1571
EP 1581
DI 10.2147/JPR.S448634 
PG 10
UT PubMed:38699068
PM 38699068
DA 2024-05-03
ER

PT J
AU Bao, T
   Deng, G
   DeMarzo, LA
   Zhi, WI
   DeRito, JL
   Blinder, V
   Chen, C
   Li, QS
   Green, J
   Pendleton, E
   Mao, JJ
AF Bao, Ting
   Deng, Gary
   DeMarzo, Lauren A
   Zhi, W Iris
   DeRito, Janice L
   Blinder, Victoria
   Chen, Connie
   Li, Qing S
   Green, Jamie
   Pendleton, Eva
   Mao, Jun J
TI A Technology-Assisted, Brief Mind-Body Intervention to Improve the Waiting Room 
SO JMIR cancer
LA English
DT Journal Article
DE acupressure; chemotherapy; meditation; mobile app; symptom relief
AB BACKGROUND: Patients waiting for chemotherapy can experience stress, anxiety, 
   nausea, and pain. Acupressure and meditation have been shown to control such 
   symptoms. OBJECTIVE: This study aimed to evaluate the feasibility and 
   effectiveness of an integrative medicine app to educate patients about these 
   self-care tools in chemotherapy waiting rooms. METHODS: We screened and enrolled 
   cancer patients in chemotherapy waiting rooms at two Memorial Sloan Kettering 
   Cancer Center locations. Patients were randomly assigned into an intervention arm 
   in which subjects watched acupressure and meditation instructional videos or a 
   control arm in which they watched a time- and attention-matched integrative 
   oncology lecture video. Before and after watching the videos, we asked the 
   patients to rate four key symptoms: stress, anxiety, nausea, and pain. We 
   performed the analysis of covariance to detect differences between the two arms 
   postintervention while controlling for baseline symptoms. RESULTS: A total of 223 
   patients were enrolled in the study: 113 patients were enrolled in the 
   intervention arm and 110 patients were enrolled in the control arm. In both 
   groups, patients showed significant reductions in stress and anxiety from 
   baseline (all P<.05), with the treatment arm reporting greater stress and anxiety 
   reduction than the control arm (1.64 vs 1.15 in stress reduction; P=.01 and 1.39 
   vs 0.78 in anxiety reduction; P=.002). The majority of patients reported that the 
   videos helped them pass time and that they would watch the videos again. 
   CONCLUSIONS: An integrative medicine self-care app in the waiting room improved 
   patients' experiences and reduced anxiety and stress. Future research could focus 
   on expanding this platform to other settings to improve patients' overall 
   treatment experiences.
C1 Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
   Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
NR 0
TC 0
SN 2369-199
EI 2369-199
J9 JMIR Cancer
PD NOV 8
PY 2019
VL 5
IS 2
BP e13217
EP e13217
DI 10.2196/13217 
PG 1
UT PubMed:31697238
PM 31697238
DA 2019-11-08
ER

PT J
AU Booher, AG
   Rico, C
   Nouvini, R
   Killoran, K
   Drullinsky, P
   Maxwell, S
   Li, S
   Jutagir, D
   McConnell, K
   Godfrey, H
   Cadwell, M
   Casaw, C
   Rosa, WE
   Muñiz, RC
   Liou, KT
AF Booher, Allison G
   Rico, Charles
   Nouvini, Rosa
   Killoran, Kathleen
   Drullinsky, Pamela
   Maxwell, Shaun
   Li, Susan
   Jutagir, Devika
   McConnell, Kelly
   Godfrey, Henry
   Cadwell, Malik
   Casaw, Camila
   Rosa, William E
   Muñiz, Rosario Costas
   Liou, Kevin T
TI Program Evaluation of Acupuncture and Massage Services Delivered for Symptom 
SO JCO oncology practice
LA English
DT Journal Article
AB PURPOSE: High symptom burden disproportionately affects minoritized racial and 
   ethnic groups during cancer treatments and exacerbates health disparities related 
   to quality of life, treatment adherence, and overall survival. Acupuncture and 
   massage have a growing evidence base for cancer symptom management, as shown in 
   recent guidelines from ASCO and the Society for Integrative Oncology. However, 
   access remains limited in community-based, underserved settings. METHODS: We 
   conducted a program evaluation of integrative medicine services at a community 
   cancer clinic in East Harlem, New York. Auricular acupuncture and massage were 
   offered 1 day a week to patients with cancer in the chemoinfusion suites at no 
   additional cost. We collected demographics and clinical characteristics of 
   patient visits, as well as types of treatments delivered and reasons treatments 
   were not received. We assessed pain, fatigue, anxiety, and nausea immediately 
   pre- and post-treatment, as well as patient satisfaction. RESULTS: From 2022 to 
   2024, we offered acupuncture or massage at 635 patient visits, which were 
   predominantly non-White (82.4%), Hispanic (44.9%), Spanish-speaking (31.7%), and 
   Medicaid-insured (45.5%). Of these 635 patient visits, 396 (62.4%) received 
   acupuncture or massage. Of the 239 who did not receive treatment, the most common 
   reasons were lack of time (54.4%) and lack of interest (38.9%). Rates of 
   treatment receipt were higher among female, Hispanic, Spanish-speaking, 
   Medicare-insured, and chemotherapy patient visits (all P < .05). Patients 
   reported reductions in pain, fatigue, anxiety, and nausea immediately 
   post-treatment. More than 90% of treatment recipients reported satisfaction with 
   the program. CONCLUSION: This program reached a diverse, underserved population 
   with historically limited access to integrative therapies. The findings highlight 
   the barriers and facilitators to bringing acupuncture and massage services to 
   community-based oncology settings.
C1 Geisel School of Medicine at Dartmouth College, Hanover, NH.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Weill Cornell Medical College, New York, NY.
   Memorial Sloan Kettering Cancer Center, New York, NY.
   Weill Cornell Medical College, New York, NY.
NR 0
TC 0
SN 2688-153
EI 2688-152
J9 JCO Oncol Pract
PD DEC 4
PY 2025
VL 0
IS 
BP OP2500321
EP OP2500321
DI 10.1200/OP-25-00321 
PG 1
UT PubMed:41343752
PM 41343752
DA 2025-12-04
ER

PT J
AU Chu, EC
   Trager, RJ
   Shum, JS
   Ng, KK
AF Chu, Eric C
   Trager, Robert J
   Shum, John S
   Ng, Kenny K
TI Sacral Giant Cell Tumor Presenting as Low Back Pain in the Chiropractic Office: A 
SO Cureus
LA English
DT Journal Article
DE chiropractic; giant cell tumors; low back pain; neoplasms; radiculopathy; sacrum
AB Sacral giant cell tumors are a rare cause of low back pain and may be challenging 
   to identify via routine clinical examination and radiography. A 47-year-old woman 
   presented to a chiropractor with a one-month history of worsening low back pain 
   with radiation to the posterior thighs, worsened with ambulation, and used a cane 
   to walk. She previously saw an orthopedic surgeon and was diagnosed with lumbar 
   spondylosis, having tried anti-inflammatory medications, exercises, and 
   acupuncture without success. The chiropractor ordered lumbar magnetic resonance 
   imaging which revealed an aggressive sacral lesion and referred the patient to an 
   oncologist. The oncologist performed positron emission tomography/computed 
   tomography and biopsy, confirming a sacral giant cell tumor. A surgical team 
   recommended tumor resection, lumbosacral fusion, radiotherapy, and zoledronic 
   acid infusion. Sacral giant cell tumors are rare and may be challenging to 
   identify via routine radiography. These tumors are an important differential to 
   consider for patients with unexplained lumbosacral symptoms unresponsive to care.
C1 New York Chiropractic and Physiotherapy Centre, New York Medical Group, Kowloon, HKG.
   Chiropractic, Connor Whole Health, University Hospitals Cleveland Medical Center, Cleveland, USA.
   College of Chiropractic, Logan University, Chesterfield, USA.
   Radiology, Hong Kong Advanced Imaging, Kowloon, HKG.
   Medical Oncology, reVIVE Oncology and Cancer Centre, Mong Kok, HKG.
NR 0
TC 0
SN 2168-818
EI 2168-818
J9 Cureus
PD FEB 7
PY 2023
VL 15
IS 1
BP e33262
EP e33262
DI 10.7759/cureus.33262 
PG 1
UT PubMed:36741639
PM 36741639
DA 2023-02-07
ER

PT J
AU Lopez, G
   Garcia, MK
   Liu, W
   Spano, M
   Underwood, S
   Dibaj, SS
   Li, Y
   Moguel, R
   Williams, J
   Bruera, E
   Cohen, L
AF Lopez, Gabriel
   Garcia, M Kay
   Liu, Wenli
   Spano, Michael
   Underwood, Susan
   Dibaj, Seyedeh S
   Li, Yisheng
   Moguel, Rocio
   Williams, Janet
   Bruera, Eduardo
   Cohen, Lorenzo
TI Outpatient acupuncture effects on patient self-reported symptoms in oncology 
SO Journal of Cancer
LA English
DT Journal Article
DE Acupuncture; Complementary health approach; Edmonton Symptom Assessment System; Integrative Medicine; Integrative Oncology; Patient Reported Outcomes
AB Background: Increased access to complementary therapies such as acupuncture at 
   academic medical centers has created new opportunities for management of cancer 
   and cancer treatment related symptoms. Methods: Patients presenting for 
   acupuncture treatment during calendar year 2016 at an outpatient integrative 
   medicine clinic in a comprehensive cancer center were asked to complete a 
   modified Edmonton Symptom Assessment Scale (ESAS; 16 symptoms, score 0-10, 10 
   worst possible) before and after each visit. ESAS subscales analyzed included 
   global (GDS; score 0-90), physical (PHS, 0-60) and psychological distress (PSS, 
   0-20). ESAS symptom score change pre/post acupuncture treatment & from baseline 
   visit to first follow up were evaluated by paired t-test. Results: Of 375 
   participants [mean age 55.6, 68.3% female, 73.9% white, most common cancer 
   diagnosis of breast (32.8%) and thoracic/head & neck (25.9%)], 73.3% had at least 
   one follow up acupuncture treatment [mean 4.6 (SD 5.1) treatments]. Highest/worst 
   symptoms at baseline were poor sleep (3.92), fatigue (3.43), well-being (3.31), 
   and pain (3.29). Statistically significant reduction/improvement (pre/post) was 
   observed for all ESAS symptoms and subscales for the initial acupuncture 
   treatment (p <0.001). Hot flashes had the highest mean reduction (-1.93), 
   followed by fatigue (-1.72), numbness/tingling (-1.70), and nausea (-1.67). 
   Clinically significant reductions were also observed for ESAS subscales of GDS 
   (-12.2), PHS (-8.5), and PSS (-2.6). For symptom change from initial acupuncture 
   treatment to first follow up (pre/pre), statistically and clinically significant 
   improvement was observed for spiritual pain (-1.10; p<0.001) and ESAS subscale of 
   GDS (-6.09; p=0.048). Clinical response rates (reduction ≥1) on follow up were 
   highest for symptoms of spiritual pain (58.9%), dry mouth (57.8%) and nausea 
   (57.3%). Conclusions: Outpatient acupuncture was associated with immediate & 
   longitudinal significant improvement across a range of symptoms commonly 
   experienced by individuals during cancer care. Further research is needed to 
   better understand frequency of treatments needed in clinical practice to help 
   maintain benefit.
C1 Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center.
   Department of Biostatistics, The University of Texas MD Anderson Cancer Center.
   Department of Biostatistics, The University of Texas MD Anderson Cancer Center.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center.
   Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center.
NR 0
TC 0
SN 1837-966
EI 1837-966
J9 J Cancer
PD OCT 13
PY 2018
VL 9
IS 19
BP 3613
EP 3619
DI 10.7150/jca.26527 
PG 6
UT PubMed:30310519
PM 30310519
DA 2018-10-13
ER

PT J
AU Li, H
   Doorenbos, AZ
   Chen, Z
   Choi, H
   Ma, W
   Danciu, O
   Patil, CL
   Gao, S
   Lif, N
   Schlaeger, JM
AF Li, Hongjin
   Doorenbos, Ardith Z
   Chen, Zhengjia
   Choi, Hannah
   Ma, Weiwei
   Danciu, Oana
   Patil, Crystal L
   Gao, Shuang
   Lif, Natalie
   Schlaeger, Judith M
TI Feasibility and Acceptability of Integrating Acupuncture for Management of 
SO Cancers
LA English
DT Journal Article
DE acupuncture; breast cancer survivors; health disparities; medically underserved; symptom management
AB BACKGROUND/OBJECTIVES: Breast cancer survivors undergoing long-term endocrine 
   therapy often experience multiple symptoms, including pain, fatigue, sleep 
   disturbance, hot flashes, anxiety, and depression. This study explored the 
   feasibility and acceptability of integrating acupuncture for symptom management 
   in medically underserved breast cancer survivors. METHODS: This randomized 
   controlled trial was conducted at two clinics serving medically underserved 
   populations. Breast cancer survivors (N = 62) were randomized to receive 
   acupuncture (n = 31) or usual care (n = 31). The acupuncture group underwent 10 
   sessions over 5 weeks. Symptoms were assessed at baseline and Weeks 6 and 12. 
   RESULTS: The majority of participants (55%) were Black, mean age was 55.2 ± 9.3 
   years, and 62.9% had a household income below $55,000. Retention (90.3%), 
   engagement (93.1%), and acceptability (92.8%) rates were high, demonstrating that 
   integrating acupuncture into care for medically underserved breast cancer 
   survivors is both feasible and acceptable. At Week 6, the acupuncture group 
   showed significant reduction compared to the usual care group in pain, fatigue, 
   sleep disturbance, depression, anxiety, and the symptom cluster score. All 
   improvements persisted to Week 12 except for those in anxiety. CONCLUSIONS: 
   Integrating acupuncture for symptom management in medically underserved breast 
   cancer survivors is both feasible and acceptable. This approach offers potential 
   benefits for reducing multiple symptoms and addressing health disparities.
C1 College of Nursing, University of Illinois Chicago, Chicago, IL 60612, USA.
   University of Illinois Cancer Center, Chicago, IL 60612, USA.
   College of Nursing, University of Illinois Chicago, Chicago, IL 60612, USA.
   University of Illinois Cancer Center, Chicago, IL 60612, USA.
   University of Illinois Cancer Center, Chicago, IL 60612, USA.
   College of Nursing, University of Illinois Chicago, Chicago, IL 60612, USA.
   University of Illinois Cancer Center, Chicago, IL 60612, USA.
   University of Illinois Cancer Center, Chicago, IL 60612, USA.
   School of Nursing, University of Michigan, Ann Arbor, MI 48109, USA.
   College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.
   College of Nursing, University of Illinois Chicago, Chicago, IL 60612, USA.
   College of Nursing, University of Illinois Chicago, Chicago, IL 60612, USA.
NR 0
TC 0
SN 2072-669
EI 2072-669
J9 Cancers (Basel)
PD JAN 25
PY 2025
VL 17
IS 2
BP 
EP 
DI 10.3390/cancers17020304 
PG 0
UT PubMed:39858086
PM 39858086
DA 2025-01-25
ER

PT J
AU Weisfeld, CC
   Turner, JA
   Dunleavy, K
   Ko, A
   Bowen, JI
   Roelk, B
   Eissa, R
   Benfield, E
   Robertson, K
AF Weisfeld, Carol Cronin
   Turner, Jill A
   Dunleavy, Kim
   Ko, Arthur
   Bowen, Jennifer I
   Roelk, Brandi
   Eissa, Reem
   Benfield, Erica
   Robertson, Kristen
TI Dealing with Anxious Patients: A Systematic Review of the Literature on 
SO Journal of alternative and complementary medicine (New York, N.Y.)
LA English
DT Journal Article
DE distraction; hypnosis; massage; music; patient anxiety; patient education
AB Objectives: State (situational) anxiety can create suboptimal outcomes for 
   patients across a variety of health care specializations. While anxiolytic 
   medications reduce anxiety, problematic side effects can compromise outcomes. 
   These challenges have spurred searches for nonpharmaceutical approaches to 
   alleviate patient anxiety. This systematic literature review, largely following 
   Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 
   aimed to determine patterns and effectiveness of interventions across medical 
   health care specialty areas, including dentistry. Methods: A systematic review 
   was conducted, using PubMed, CINAHL, and PsycINFO databases, with search terms 
   related to anxiety, specific interventions, and medical or dental procedures. 
   Hand searching for additional citations was performed on the bibliographies of 
   dissertations, meta-analyses, and systematic reviews that met article inclusion 
   criteria. The search process yielded 48,324 articles and 257 dissertations 
   published in English between 1974 and 2018. Each abstract was evaluated for 
   inclusion by two reviewers, yielding 718 articles that were read and evaluated 
   for outcomes, risk of bias, pretest and post-test, controls and quality, using a 
   Critical Appraisal Skills Programme instrument. Of these, 408 articles, 
   describing 501 experimental trials, were accepted for inclusion in this analysis. 
   Results: A total of 50,343 patients were included in these experiments, with an 
   overall success rate of 71% for reducing patient anxiety. Results are summarized 
   by health care specialty area: surgery, oncology, cardiology, 
   obstetrics/gynecology, dentistry, and pain/trauma, and the following diagnostic 
   testing and intervention areas: imaging, colonoscopy, mechanical ventilation, and 
   other. The largest number of experiments (114) was in the surgery category. The 
   types of interventions included music, education, relaxation, cognitive 
   behavioral therapy (CBT), massage, distraction, hypnosis, 
   acupuncture/acupressure, social support, aromatherapy, nature sounds, natural 
   visual stimuli, special garment, and other. The largest numbers of experiments 
   were done with music (143) and education (130). Discussion: The following 
   interventions were most successful, reducing anxiety in over 70% of experiments: 
   music, CBT, relaxation, massage, acupuncture/acupressure, hypnosis, and natural 
   sounds. Confidence in results is limited by publication bias, small sample sizes, 
   and the lack of placebo controls. Directions for future research are discussed.
C1 Department of Psychology, University of Detroit Mercy, Detroit, MI, USA.
   Libraries/IDS, University of Detroit Mercy, Detroit, MI, USA.
   Department of Physical Therapy, University of Florida, Gainesville, FL, USA.
   McAuley School of Nursing, College of Health Professions, University of Detroit Mercy, Detroit, MI, USA.
   Libraries/IDS, University of Detroit Mercy, Detroit, MI, USA.
   Department of Psychology, University of Detroit Mercy, Detroit, MI, USA.
   Department of Psychology, University of Detroit Mercy, Detroit, MI, USA.
   Department of Psychology, University of Detroit Mercy, Detroit, MI, USA.
   Orthopedic Physical Therapy Program, Walk the Line Recovery Therapy, Southfield, MI, USA.
NR 0
TC 0
SN 1557-770
EI 
J9 J Altern Complement Med
PD JUN 3
PY 2021
VL 27
IS 9
BP 717
EP 726
DI 10.1089/acm.2020.0504 
PG 9
WC Anxiety; prevention & control; Anxiety Disorders; Aromatherapy; Dentistry; Female; Humans; Hypnosis; Pregnancy
UT PubMed:34076531
PM 34076531
DA 2021-06-03
ER

PT J
AU Guo, Q
   Di, Z
   Tian, HF
   Zhang, QA
AF Guo, Qin
   Di, Zhong
   Tian, Hong-Fang
   Zhang, Quan-Ai
TI Contralateral Acupuncture for the Treatment of Phantom Limb Pain and Phantom Limb 
SO Frontiers in neuroscience
LA English
DT Journal Article
DE acupuncture; contralateral acupuncture; phantom limb; phantom limb pain (PLP); phantom limb sensation (PLS)
AB Phantom limb pain (PLP) and phantom limb sensation (PLS) are common and 
   distressing sequelae of amputation. Current pain management following amputation 
   is challenging and unsatisfying. In this case study, a 74-year-old woman 
   underwent above-knee amputation because of the rhabdomyosarcoma in the right leg. 
   Despite several analgesics, pain was poorly controlled. The phantom limb pain and 
   sensation were immediately reduced by the contralateral acupuncture, and 
   abolished after the third session with no side-effects, no relapse during the 
   next 9 months. Contralateral acupuncture showed positive effect on PLP and PLS in 
   this case, but more robust evidence would be needed to support the efficacy of 
   this treatment technique for indication.
C1 Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
NR 0
TC 0
SN 1662-453
EI 1662-454
J9 Front Neurosci
PD NOV 9
PY 2021
VL 15
IS 
BP 713548
EP 713548
DI 10.3389/fnins.2021.713548 
PG 0
UT PubMed:34744604
PM 34744604
DA 2021-11-09
ER

PT J
AU Li, FF
   Zhang, LN
   Tang, F
   Liu, YC
AF Li, Fang-Fang
   Zhang, Li-Na
   Tang, Fen
   Liu, Yu-Chen
TI Randomized Controlled Trial of Wrist-Ankle Acupuncture for Postoperative 
SO Cancer nursing
LA English
DT Journal Article
DE Day surgery; Pain; Randomized controlled trial; Thyroid cancer; Traditional Chinese medicine; Wrist-ankle acupuncture therapy
AB BACKGROUND: Postoperative pharyngeal pain is common in patients with thyroid 
   cancer undergoing day-case surgery, with approximately 60%-90% affected. 
   Wrist-ankle acupuncture (WAA) offers a potential alternative but lacks clinical 
   validation in day surgery settings. OBJECTIVE: This study aimed to assess the 
   effectiveness and safety of WAA in reducing postoperative pharyngeal pain in 
   patients with thyroid cancer undergoing day-case surgery. METHODS: Seventy-two 
   patients undergoing thyroidectomy were randomized into the WAA experimental group 
   (n = 36) or the control group (n = 36). The WAA experimental group received 
   standardized care plus subcutaneous needle insertion at wrist points (Upper 1 and 
   Upper 6) postoperatively, whereas the control group received standard care alone. 
   Pain was assessed using the visual analog scale at 3, 4, 9, and 27 hours, and 
   predischarge. Secondary outcomes included the Houston Pain Outcome Instrument and 
   the 15-item Quality of Recovery scale. RESULTS: At 9 and 27 hours post surgery, 
   the experimental group reported significantly lower pain scores ( P < .001); 
   satisfaction with pain control was also significantly higher ( P < .001). The WAA 
   group had minor adverse events and no serious complications. Additionally, the 
   experimental group experienced better postoperative sleep and overall health ( P 
   < .05). CONCLUSIONS: Wrist-ankle acupuncture significantly relieves postoperative 
   sore throat in patients with thyroid cancer during day surgery. This work 
   establishes a foundation for integrating WAA into modern surgical recovery 
   pathways. However, larger randomized controlled trials are needed to determine 
   effectiveness across different institutions and populations. IMPLICATIONS FOR 
   PRACTICE: Wrist-ankle acupuncture offers a nonpharmacological alternative for 
   pain management in thyroid cancer surgery. Further studies are needed to confirm 
   its broader applicability and effectiveness in diverse patient populations.
C1 Author Affiliations: Ambulatory Surgery Center (Mss Li, Zhang, and Tang) and Department of Otolaryngology, Head and Neck Surgery (Dr Liu), The FirstAffiliated Hospital of Anhui Medical University, Hefei, China.
NR 0
TC 0
SN 1538-980
EI 
J9 Cancer Nurs
PD SEP 30
PY 2025
VL 0
IS 
BP 
EP 
DI 10.1097/NCC.0000000000001547 
PG 0
UT PubMed:41026681
PM 41026681
DA 2025-09-30
ER

PT J
AU Mehling, WE
   Lown, EA
   Dvorak, CC
   Cowan, MJ
   Horn, BN
   Dunn, EA
   Acree, M
   Abrams, DI
   Hecht, FM
AF Mehling, Wolf E
   Lown, E Anne
   Dvorak, Christopher C
   Cowan, Morton J
   Horn, Biljana N
   Dunn, Elizabeth A
   Acree, Michael
   Abrams, Donald I
   Hecht, Frederick M
TI Hematopoietic cell transplant and use of massage for improved symptom management: 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB Background. Pediatric hematopoietic cell transplant (HCT) is a lifesaving 
   treatment that often results in physical and psychological discomfort. An 
   acupressure-massage intervention may improve symptom management in this setting. 
   Methods. This randomized controlled pilot trial compared a combined 
   massage-acupressure intervention to usual care. Children were offered three 
   practitioner-provided sessions per week throughout hospitalization. Parents were 
   trained to provide additional acupressure as needed. Symptoms were assessed using 
   nurses' reports and two questionnaires, the behavioral affective and somatic 
   experiences scale and the Peds quality of life cancer module. Results. We 
   enrolled 23 children, ages 5 to 18. Children receiving the intervention reported 
   fewer days of mucositis (Hedges' g effect size ES = 0.63), lower overall symptom 
   burden (ES = 0.26), feeling less tired and run-down (ES = 0.86), having fewer 
   moderate/severe symptoms of pain, nausea, and fatigue (ES = 0.62), and less pain 
   (ES = 0.42). The intervention group showed trends toward increasing 
   contentness/serenity (ES = +0.50) and decreasing depression (ES = -0.45), but not 
   decreased anxiety (ES = +0.42). Differences were not statistically significant. 
   Discussion. Feasibility of studying massage-acupressure was established in 
   children undergoing HCT. Larger studies are needed to test the efficacy of such 
   interventions in reducing HCT-associated symptoms in children.
C1 Osher Center for Integrative Medicine, University of California, San Francisco, CA 94115, USA.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD MAR 29
PY 2012
VL 2012
IS 
BP 450150
EP 450150
DI 10.1155/2012/450150 
PG 0
UT PubMed:22454665
PM 22454665
DA 2012-03-29
ER

PT J
AU Zhang, J
   Zhang, H
   Zheng, J
   Niu, C
   Zhu, S
   Hu, H
   Lu, Y
   Zhu, M
AF Zhang, Jiamin
   Zhang, Hao
   Zheng, Junfei
   Niu, Cong
   Zhu, Shu
   Hu, Haiqing
   Lu, Ye
   Zhu, Meihua
TI Safety and Effectiveness of Electroacupuncture During Colon Endoscopic Submucosal 
SO Journal of pain research
LA English
DT Journal Article
DE electroacupuncture; endoscopic submucosal dissection; propofol; remifentanil
AB BACKGROUND: Endoscopic treatment of early colon neoplasms has evolved as a valid 
   and less traumatic alternative to surgical resection. It can usually be performed 
   with sedation on an outpatient basis. The present study was performed to 
   determine the safety and effectiveness of electroacupuncture (EA) versus propofol 
   sedation during endoscopic submucosal dissection (ESD) for early colon neoplasm. 
   METHODS: A total of 150 adult outpatients undergoing ESD were selected and 
   divided into the EA combined with propofol group (EP group), remifentanil 
   combined with propofol group (RP group), and propofol group (SP group), with 50 
   patients in each group. All patients received standard sedation with propofol. 
   Acupuncture was performed before intravenous propofol injection in the EP group. 
   A density wave of 1-3 mA, 2/100 hz current was administered for 20 min before the 
   induction of anesthesia. The effectiveness of sedation was measured by 
   satisfaction levels, and pain and sedation scores were measured by 
   questionnaires. Respiratory and hemodynamic complications were monitored and 
   compared as indices of safety. RESULTS: Demographic data were comparable among 
   the three groups. The total dose of propofol and the percentage of body movement 
   in the EP group were lower than in the SP and RP groups (P<0.01). The incidence 
   of hypotension and bradycardia in the SP and RP groups was higher than in the EP 
   group. Patients who received the EA intervention showed a significant reduction 
   in hypoxemia. The endoscopists felt that the procedure was more favorable in the 
   EP group, but, there was no significant difference of patient satisfaction scores 
   among three groups. CONCLUSION: Sedation with EA is effective and safe for 
   patients undergoing ESD, and could improve the satisfaction levels of patients 
   and gastroendoscopists.
C1 Department of Anesthesiology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210017, People's Republic ofChina.
   Department of Anesthesiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, People's Republic of China.
   Department of Anesthesiology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210017, People's Republic ofChina.
   Department of Anesthesiology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210017, People's Republic ofChina.
   Department of Anesthesiology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210017, People's Republic ofChina.
   Department of Anesthesiology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210017, People's Republic ofChina.
   Department of Surgery, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210017, People's Republic of China.
   Department of Anesthesiology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210017, People's Republic ofChina.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD MAR 19
PY 2025
VL 18
IS 
BP 1221
EP 1229
DI 10.2147/JPR.S501941 
PG 8
UT PubMed:40104825
PM 40104825
DA 2025-03-19
ER

PT J
AU Kim, KM
   Kang, EY
   Lee, SH
   Jung, AY
   Nam, DH
   Cheon, JH
AF Kim, Kyoung Min
   Kang, Eun Young
   Lee, Sung Hoon
   Jung, A Young
   Nam, Doo Hyoun
   Cheon, Ji Hwan
TI Therapeutic approach of wrist ganglion using electroacupuncture: two case 
SO Annals of rehabilitation medicine
LA English
DT Journal Article
DE Electroacupuncture; Ganglion cysts
AB A ganglion cyst is a relatively common benign tumor on the wrist. Conservative 
   and surgical approaches have been used for its treatment. Various conservative 
   treatment methods have been suggested such as reassurance, aspiration, sclerosant 
   injection, and direct compression. But, there is no acceptable treatment of 
   choice yet because each suggested method has a relatively high recurrence rate. 
   We want to report two cases in which the size of the wrist ganglion was decreased 
   by using electroacupuncture. One patient presented with a chronic ganglion for 
   six years and the other patient presented with a recently occurred acute 
   ganglion. We applied electroacupuncture for 20 minutes once a week for eight 
   weeks to both of them. Afterwards, the size of the wrist ganglion diminished in 
   the follow-up sonography and the accompanying pain was also relieved. Herein we 
   report both cases along with a review of the relevant literature.
C1 Department of Rehabilitation Medicine, Kwangju Christian Hospital, Gwangju, Korea.
   Department of Rehabilitation Medicine, Kwangju Christian Hospital, Gwangju, Korea.
   Department of Rehabilitation Medicine, Kwangju Christian Hospital, Gwangju, Korea.
   Department of Rehabilitation Medicine, Kwangju Christian Hospital, Gwangju, Korea.
   Department of Rehabilitation Medicine, Kwangju Christian Hospital, Gwangju, Korea.
   Department of Rehabilitation Medicine, Kwangju Christian Hospital, Gwangju, Korea.
NR 0
TC 0
SN 2234-065
EI 2234-064
J9 Ann Rehabil Med
PD JUL 16
PY 2014
VL 38
IS 3
BP 415
EP 20
DI 10.5535/arm.2014.38.3.415 
PG -395
UT PubMed:25024969
PM 25024969
DA 2014-07-16
ER

PT J
AU Yuan, M
   Wang, X
   Yan, X
   Ding, H
   Yi, J
   Xia, H
   Yu, X
AF Yuan, Minghua
   Wang, Xiaoyuan
   Yan, Xiaoyan
   Ding, Hong
   Yi, Jing
   Xia, Hongmei
   Yu, Xueqin
TI Effects of heat-sensitive moxibustion combined with naprapathy and warming needle 
SO American journal of translational research
LA English
DT Journal Article
DE Heat-sensitive moxibustion; inflammatory factor; naprapathy; periarthritis of shoulder; shoulder function; warming needle moxibustion
AB OBJECTIVE: To evaluate the effects of heat-sensitive moxibustion (HSM) combined 
   with naprapathy and warming needle moxibustion (WNM) combined with naprapathy on 
   shoulder function and serum levels of calcitonin gene-related peptide (CGRP), 
   substance P (SP), tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) in 
   patients with periarthritis of shoulder (POS). METHODS: From July 2017 to July 
   2020, sixty patients with POS admitted to our hospital were selected as the study 
   subjects, and divided into HSM group (n=29) receiving HSM combined with 
   naprapathy and WNM group receiving WNM combined with naprapathy (n=31). The 
   changes in shoulder function, degrees of pain and serum levels of CGRP, SP, TNF-α 
   and IL-2 were compared between the two groups. RESULTS: After treatment, the 
   scores of myodynamia, pain, range of motion (ROM) of shoulder joint and 
   activities of daily living (ADLs) were improved in both groups (P<0.05), and the 
   scores in HSM group were remarkably higher than those in WNM group (P<0.05). 
   Visual analogue scale (VAS) scores after 3 courses of treatment were lower than 
   those after 1 and 2 courses of treatment respectively (P<0.05), and the VAS 
   scores in HSM group were markedly lower than those in WNM group after 1, 2, and 3 
   courses of treatment (P<0.05). After treatment, the serum levels of CGRP, SP, 
   TNF-α and IL-2 were decreased in both groups (P<0.05), and the levels in HSM 
   group were noticeably lower than those in WNM group (P<0.05). CONCLUSION: HSM 
   combined with naprapathy is superior to WNM combined with naprapathy in 
   inhibition of inflammatory factors of pain and serum inflammatory factors, 
   alleviating the pain and promoting the restoration of shoulder function in 
   patients with POS.
C1 Rehabilitation Department, Yichun People's Hospital Yichun 336000, Jiangxi, China.
   Rehabilitation Department, Yichun People's Hospital Yichun 336000, Jiangxi, China.
   Rehabilitation Department, Yichun People's Hospital Yichun 336000, Jiangxi, China.
   Rehabilitation Department, Yichun People's Hospital Yichun 336000, Jiangxi, China.
   Rehabilitation Department, Yichun People's Hospital Yichun 336000, Jiangxi, China.
   Rehabilitation Department, Yichun People's Hospital Yichun 336000, Jiangxi, China.
   Rehabilitation Department, Yichun People's Hospital Yichun 336000, Jiangxi, China.
NR 0
TC 0
SN 1943-814
EI 1943-814
J9 Am J Transl Res
PD AUG 12
PY 2021
VL 13
IS 7
BP 7804
EP 7811
DI 
PG 7
UT PubMed:34377257
PM 34377257
DA 2021-08-12
ER

PT J
AU Kim, HW
   Yoo, JE
AF Kim, Hae-Won
   Yoo, Jeong-Eun
TI Inhibitory effect of traditional Korean medicine on the recurrent endometriosis 
SO Integrative medicine research
LA English
DT Journal Article
DE Boheotang; Dienogest; Endometriosis; Laparoscopic surgery; traditional Korean medicine
AB Endometriosis is a common benign gynecologic tumor, and it can destroy a 
   patient's life. Surgery and hormone therapy are established therapies for 
   endometriosis. However, there are many cases of recurrent endometriosis after 
   conventional therapies. This report presents a case of a patient who has 
   repetitive recurrence of endometriosis after laparoscopic excision and hormone 
   therapy. A 32-years-old female patient first had laparoscopic surgery to remove 
   endometriosis in 2011. The disease recurred two more times after the first 
   excision. Hormone therapy by dienogest and two more laparoscopic surgeries were 
   done in 2012 and 2014. With acupuncture, moxibustion, fumigation therapy, and 
   herbal medicine therapy, endometriosis didn't recur during treatment and 
   observation period of 34 months. Menstrual pain numeric rating scales (NRS) 
   decreased from 2 to none. Shortened menstrual cycle (24 days) after second 
   surgery became longer (26.63 ± 2.28 days) after traditional Korean medicine 
   therapy. This case presents the therapeutic potential of TKM for inhibitory 
   effect on the recurrent endometriosis after laparoscopic excision and hormone 
   therapy.
C1 Dept. of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Dae-jeon University, Korea.
   Dept. of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Dae-jeon University, Korea.
NR 0
TC 0
SN 2213-423
EI 2213-422
J9 Integr Med Res
PD OCT 3
PY 2018
VL 7
IS 3
BP 296
EP 301
DI 10.1016/j.imr.2018.07.003 
PG 5
UT PubMed:30271719
PM 30271719
DA 2018-10-03
ER

PT J
AU Etchegaray, A
   Mudaliar, S
   Devereaux, B
AF Etchegaray, Amirah
   Mudaliar, Sanjivan
   Devereaux, Benedict
TI Endosonographically confirmed type III choledochal cyst managed with endoscopic 
SO VideoGIE : an official video journal of the American Society for Gastrointestinal 
LA English
DT Journal Article
AB BACKGROUND AND AIMS: Type III choledochal cysts consist of a cystic dilatation of 
   the intraduodenal portion of the common bile duct and represent the rarest 
   subtype, with a low risk of malignancy. Traditionally, choledochoceles are 
   treated with surgical resection or endoscopic choledochal cyst fenestration with 
   cannulation of the cyst via the native papilla and marsupialization using a 
   sphincterotome. We describe a novel approach to management of a type IIIA 
   choledochal cyst with endoscopic needle-knife division and marsupialization of a 
   type IIIA choledochal cyst. METHODS: A 19-year-old male nonsmoker with a 5-year 
   history of intermittent, colicky epigastric pain was referred to our tertiary 
   center for management of a large (69 × 53 × 89 mm) type IIIA choledochal cyst 
   confirmed on MRCP. Duodenoscopy revealed a large pendulous mass, with significant 
   medial displacement of the duodenum and intermittent gastric outlet obstruction, 
   that prevented clear visualization of the distally located papilla. After careful 
   multidisciplinary team discussion, it was decided that endoscopic needle-knife 
   division and marsupialization would be undertaken to reduce biliary stasis and 
   the chance of further ductal stone formation. RESULTS: Needle-knife division was 
   performed using a freehand technique using ENDO CUT I (30 W, 3d 3i). To 
   decompress the cyst, a large incision was made from the inferior to superior 
   position on the luminal aspect of the cyst. Further incisions were made to 
   marsupialize the cyst cavity and allow complete drainage of the cystic content 
   into the duodenum. The patient tolerated the procedure well, with no bleeding 
   postprocedure. Serial imaging demonstrated complete resolution of the large 
   choledochal cyst, with no adverse events at last follow-up (12 months after the 
   procedure). CONCLUSIONS: Endoscopic needle-knife division and marsupialization is 
   an effective novel approach for the treatment of symptomatic choledochoceles; 
   however, more data are required to evaluate the long-term safety of this 
   approach.
C1 Department of Gastroenterology and Hepatology, Royal Brisbane and Women's Hospital, Herston, Australia.
   University of Queensland, Brisbane, Australia.
   Department of Gastroenterology and Hepatology, Royal Brisbane and Women's Hospital, Herston, Australia.
   University of Queensland, Brisbane, Australia.
   Department of Gastroenterology and Hepatology, Royal Brisbane and Women's Hospital, Herston, Australia.
   University of Queensland, Brisbane, Australia.
NR 0
TC 0
SN 2468-448
EI 
J9 VideoGIE
PD JUL 24
PY 2025
VL 10
IS 8
BP 406
EP 409
DI 10.1016/j.vgie.2025.03.035 
PG 3
UT PubMed:40704112
PM 40704112
DA 2025-07-24
ER

PT J
AU Xu, X
   Zhou, MM
   Hao, HY
   Chen, HY
AF Xu, Xiao
   Zhou, Ming-Ming
   Hao, Hai-Yan
   Chen, Hai-Yan
TI Enhancing peri-operative pain management in urological cancer: exploring the role 
SO BJU international
LA English
DT Letter
C1 Research Center of Molecular Medicine (Ph.D. Lab), Nantong Health College of Jiangsu Province, Nantong, China.
   Department of Nursing, Nantong Health College of Jiangsu Province, Nantong, 
   Research Center of Molecular Medicine (Ph.D. Lab), Nantong Health College of Jiangsu Province, Nantong, China.
   Department of Nursing, Nantong Health College of Jiangsu Province, Nantong, 
   Clinical Research Unit, Affiliated Hospital of Nantong University, Nantong, China.
   Department of Urology, Nantong Hospital of Traditional Chinese Medicine, Affiliated Nantong Hospital of Nanjing University of Chinese Medicine, Nantong,China.
NR 0
TC 0
SN 1464-410
EI 
J9 BJU Int
PD MAR 19
PY 2025
VL 135
IS 6
BP 1060
EP 1061
DI 10.1111/bju.16700 
PG 1
UT PubMed:40104920
PM 40104920
DA 2025-03-19
ER

PT J
AU Zhang, Y
   Sun, Y
   Li, D
   Liu, X
   Fang, C
   Yang, C
   Luo, T
   Lu, H
   Li, H
   Zhang, H
   Liang, Q
   Wu, J
   Huang, L
   Xu, R
   Ren, L
   Chen, Q
AF Zhang, Yuzhu
   Sun, Yang
   Li, Dongmei
   Liu, Xiaoyuan
   Fang, Chen
   Yang, Chunmin
   Luo, Tianyu
   Lu, Hai
   Li, Huachao
   Zhang, Hongyan
   Liang, Qianyi
   Wu, Jiahua
   Huang, Limei
   Xu, Rui
   Ren, Liping
   Chen, Qianjun
TI Acupuncture for Breast Cancer: A Systematic Review and Meta-Analysis of 
SO Frontiers in oncology
LA English
DT Journal Article
DE acupuncture; breast cancer; meta-analysis; patient-reported outcome; systematic review
AB ABSTRACT: The present systematic review and meta-analysis was undertaken to 
   evaluate the effects of acupuncture in women with breast cancer (BC), focusing on 
   patient-reported outcomes (PROs). METHODS: A comprehensive literature search was 
   carried out for randomized controlled trials (RCTs) reporting PROs in BC patients 
   with treatment-related symptoms after undergoing acupuncture for at least four 
   weeks. Literature screening, data extraction, and risk bias assessment were 
   independently carried out by two researchers. RESULTS: Out of the 2, 524 
   identified studies, 29 studies representing 33 articles were included in this 
   meta-analysis. At the end of treatment (EOT), the acupuncture patients' quality 
   of life (QoL) was measured by the QLQ-C30 QoL subscale, the Functional Assessment 
   of Cancer Therapy-Endocrine Symptoms (FACT-ES), the Functional Assessment of 
   Cancer Therapy-General/Breast (FACT-G/B), and the Menopause-Specific Quality of 
   Life Questionnaire (MENQOL), which depicted a significant improvement. The use of 
   acupuncture in BC patients lead to a considerable reduction in the scores of all 
   subscales of the Brief Pain Inventory-Short Form (BPI-SF) and Visual Analog Scale 
   (VAS) measuring pain. Moreover, patients treated with acupuncture were more 
   likely to experience improvements in hot flashes scores, fatigue, sleep 
   disturbance, and anxiety compared to those in the control group, while the 
   improvements in depression were comparable across both groups. Long-term 
   follow-up results were similar to the EOT results. CONCLUSIONS: Current evidence 
   suggests that acupuncture might improve BC treatment-related symptoms measured 
   with PROs including QoL, pain, fatigue, hot flashes, sleep disturbance and 
   anxiety. However, a number of included studies report limited amounts of certain 
   subgroup settings, thus more rigorous, well-designed and larger RCTs are needed 
   to confirm our results.
C1 Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Department, Zhuhai Hospital of Guangdong Province Hospital of Chinese Medicine, Zhuhai, China.
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
   Breast Clinic Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
   Breast Clinic Center, The Second Affiliated Hospital of Guangzhou University of 
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD JUN 29
PY 2021
VL 11
IS 
BP 646315
EP 646315
DI 10.3389/fonc.2021.646315 
PG 0
UT PubMed:34178633
PM 34178633
DA 2021-06-29
ER

PT J
AU Chen, J
   Fu, T
   Liu, L
   Xie, Y
   Li, Y
AF Chen, Jiu
   Fu, Tianxiao
   Liu, Li
   Xie, Yirui
   Li, Youdi
TI Effect of acupuncture inclusion in the enhanced recovery after surgery protocol 
SO Frontiers in oncology
LA English
DT Journal Article
DE acupuncture; enhanced recovery after surgery; gastrointestinal function; meta-analysis; tumor
AB INTRODUCTION: Acupuncture has been shown to be effective in restoring 
   gastrointestinal function in tumor patients receiving the enhanced recovery after 
   surgery (ERAS) protocol. The present systematic review and meta-analysis aimed to 
   evaluate the rationality and efficacy of integrating acupuncture in the ERAS 
   strategy to recuperate gastrointestinal function. METHODS: We searched eleven 
   databases for relevant randomized clinical trials (RCTs) of acupuncture for the 
   treatment of gastrointestinal dysfunction in tumor patients treated with the ERAS 
   protocol. The quality of each article was assessed using the Cochrane 
   Collaboration risk of bias criteria and the modified Jadad Scale. As individual 
   symptoms, the primary outcomes were time to postoperative oral food intake, time 
   to first flatus, time to first distension and peristaltic sound recovery time 
   (PSRT). Pain control, adverse events, and acupoint names reported in the included 
   studies were also investigated. RESULTS: Of the 211 reviewed abstracts, 9 studies 
   (702 patients) met eligibility criteria and were included in the present 
   systematic review and meta‑analysis. Compared to control groups, acupuncture 
   groups showed a significant reduction in time to postoperative oral food intake 
   [standardized mean difference (SMD) = -0.77, 95% confidence interval (CI) -1.18 
   to -0.35], time to first flatus (SMD=-0.81, 95% CI -1.13 to -0.48), time to first 
   defecation (SMD=-0.91, 95% CI -1.41 to -0.41, PSRT (SMD=-0.92, 95% CI -1.93 to 
   0.08), and pain intensity (SMD=-0.60, 95% CI -0.83 to -0.37).The Zusanli (ST36) 
   and Shangjuxu (ST37) acupoints were used in eight of the nine included studies. 
   Adverse events related to acupuncture were observed in two studies, and only one 
   case of bruising was reported. DISCUSSION: The present systematic review and 
   meta‑analysis suggested that acupuncture significantly improves recovery of 
   gastrointestinal function and pain control in tumor patients receiving the ERAS 
   protocol compared to the control group. Moreover, ST36 and ST37 were the most 
   frequently used acupoints. Although the safety of acupuncture was poorly 
   described in the included studies, the available data suggested that acupuncture 
   is a safe treatment with only mild side effects. These findings provide 
   evidence-based recommendations for the inclusion of acupuncture in the ERAS 
   protocol for tumor patients. SYSTEMATIC REVIEW REGISTRATION: 
   https://www.crd.york.ac.uk/prospero/ PROSPERO, identifier CRD42023430211.
C1 Department of Traditional Chinese Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
   Department of Traditional Chinese Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
   Department of Library, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
   State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Centerfor Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
   The Department of Infectious Diseases, The First Affiliated Hospital, School of 
   Department of Traditional Chinese Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD SEP 1
PY 2023
VL 13
IS 
BP 1232754
EP 1232754
DI 10.3389/fonc.2023.1232754 
PG 0
UT PubMed:37655096
PM 37655096
DA 2023-09-01
ER

PT J
AU Seo, YJ
   Jeong, YS
   Park, HS
   Park, SW
   Choi, JY
   Jung, KJ
   Lim, JY
AF Seo, Young Jae
   Jeong, Yong Sung
   Park, Hyo Sik
   Park, Shin Who
   Choi, Ja Young
   Jung, Kang Jae
   Lim, Jong Youb
TI Late-Onset Post-radiation Lymphedema Provoked by Bee Venom Therapy: A Case 
SO Annals of rehabilitation medicine
LA English
DT Journal Article
DE Acupuncture; Bee venoms; Lymphedema
AB Lymphedema is a common complication associated with cancer itself or with cancer 
   treatment. Lymphedema infrequently occurs after drug therapy. Bee venom is one of 
   the materials used in acupuncture, and it has been used in the treatment of a 
   variety of inflammatory diseases including arthritis. We report a 74-year-old 
   male patient with late-onset post-radiation lymphedema provoked by bee venom 
   therapy. He was free of lymphedema for 5 years after the complete remission of 
   prostate cancer which had been treated with transurethral resection and radiation 
   therapy. The patient developed left leg swelling after undergoing bee venom 
   therapy for left hip pain. Computed tomography and lymphoscintigraphy showed 
   lymphedema without tumor recurrence or infection. The lymphatic system was 
   suspected to be injured by bee venom therapy and lymphedema was provoked. Bee 
   venom therapy should be used cautiously in patients prone to lymphedema.
C1 Department of Rehabilitation Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
   Department of Rehabilitation Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
   Department of Rehabilitation Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
   Department of Rehabilitation Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
   Department of Rehabilitation Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
   Department of Rehabilitation Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
   Department of Rehabilitation Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
NR 0
TC 0
SN 2234-065
EI 2234-064
J9 Ann Rehabil Med
PD SEP 6
PY 2018
VL 42
IS 4
BP 626
EP 629
DI 10.5535/arm.2018.42.4.626 
PG 3
UT PubMed:30180534
PM 30180534
DA 2018-09-06
ER

PT J
AU Wu, Z
   Liu, Q
AF Wu, Zanhua
   Liu, Qinghua
TI Effects of repetitive transcranial magnetic stimulation combined with acupuncture 
SO American journal of translational research
LA English
DT Journal Article
DE IGF-1; NLRP3; Repetitive transcranial magnetic stimulation; acupuncture; inflammatory factor; neuropathic pain
AB PURPOSE: This study aimed to investigate whether repetitive transcranial magnetic 
   stimulation (rTMS) combined with acupuncture could alleviate pain in patients 
   suffering from postherpetic neuralgia (PHN) by inhibiting NOD-like receptor 3 
   (NLRP3) inflammasome activation. METHODS: Data of 92 PHN patients were 
   retrospectively collected. The patients were grouped as control (nerve block), 
   rTMS, and rTMS + acupuncture groups according to treatment methods. The visual 
   analogue scale (VAS) score, as well as tumor necrosis factor (TNF)-α, interleukin 
   (IL)-1β, IL-6, NLRP3, and Caspase-1 levels of patients in each group prior and 
   post-treatment were analyzed. RESULTS: The rTMS + acupuncture group showed higher 
   efficacy than the rTMS group and the control group, contributing to markedly 
   lower VAS score, as well as TNF-α, IL-1β, IL-6, NLRP3 and Caspase-1 levels than 
   the other two groups (P < 0.05). CONCLUSION: rTMS plus acupuncture can reduce the 
   inflammatory immune response and ease the pain in patients by inhibiting NLRP3 
   inflammasome and its resulting inflammatory factors, Caspase-1 and IL-1β.
C1 Department of Rehabilitation Medicine, People's Hospital of Guangxi Zhuang Autonomous Region Nanning 530000, Guangxi, The People's Republic of China.
   Department of Rehabilitation Medicine, People's Hospital of Guangxi Zhuang Autonomous Region Nanning 530000, Guangxi, The People's Republic of China.
   Department of Orthopaedics, Hanzhong 3201 Hospital Hanzhong 723000, Shaanxi, The 
NR 0
TC 0
SN 1943-814
EI 1943-814
J9 Am J Transl Res
PD AUG 10
PY 2023
VL 15
IS 7
BP 4699
EP 4708
DI 
PG 9
UT PubMed:37560225
PM 37560225
DA 2023-08-10
ER

PT J
AU Yu, ML
   Qian, JJ
   Fu, SP
   Chen, JY
   Zheng, YW
   Lu, ZG
   Lu, SF
AF Yu, Mei-Ling
   Qian, Jia-Jia
   Fu, Shu-Ping
   Chen, Jia-Ying
   Zheng, Yu-Wen
   Lu, Zhi-Gang
   Lu, Sheng-Feng
TI Acupuncture for Cancer-Induced Bone Pain in Animal Models: A Systemic Review and 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Review
AB BACKGROUND: Cancer-induced bone pain (CIBP) is a highly prevalent symptom, which 
   afflicts vast majority of patients who suffer from cancer. The current treatment 
   options failed to achieve satisfactory effect and the side effects were 
   prominent. Recent randomized controlled trials (RCTs) of animal demonstrate the 
   benefit of acupuncture for CIBP. We sought to determine if the pooled data from 
   available RCTs supports the use of acupuncture for CIBP. METHODS: A literature 
   search for randomized controlled trials was conducted in six electronic databases 
   from inception to May 31, 2019. Meta-analysis was performed with Review Manager 
   5.3 software; the publication bias was assessed by Stata 12.0 software. We used 
   random effects model for pooling data because heterogeneity is absolute among 
   studies to some extent. RESULTS: Twenty-four trials were included in the review, 
   of which 12 trials provided detailed data for meta-analyses. Preliminary evidence 
   indicates that compared to wait list/sham group, acupuncture was effective on 
   increasing paw withdrawal threshold (PWT) and paw withdrawal latency (PWL). 
   Compared to medicine, acupuncture was less effective on PWT, but as effective as 
   medicine on PWL. Acupuncture can reinforce medicine's effect on PWT and PWL. 
   Compared to the control group, acupuncture was superior to increase body weight 
   (BW), decrease spinal cord glial fibrillary acidic protein (GFAP), and 
   interleukin-1β (IL-1β). Furthermore, some studies showed acupuncture delay or 
   partially reverse morphine tolerance. Three studies found acupuncture has no 
   effect on PWT, but 2 of them found acupuncture could enhance small dose of 
   Celebrex's effect on CIBP. CONCLUSIONS: Acupuncture was superior to wait 
   list/sham acupuncture on increasing PWT and has no less effect on increasing PWL 
   compared to medicine; acupuncture improved the efficacy of drugs, increased the 
   CIBP animals' body weight, and decreased their spinal cord GFAP and IL-1β. 
   High-quality studies are necessary to confirm the results.
C1 First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   Acupuncture and Rehabilitation College, Nanjing University of Chinese Medicine, 
   First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   Acupuncture and Rehabilitation College, Nanjing University of Chinese Medicine, 
   Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   Acupuncture and Rehabilitation College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   Acupuncture and Rehabilitation College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
   College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, 
   Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD AUG 18
PY 2020
VL 2020
IS 
BP 5606823
EP 5606823
DI 10.1155/2020/5606823 
PG 0
UT PubMed:32802130
PM 32802130
DA 2020-08-18
ER

PT J
AU Brown, ML
   Rojas, E
   Gouda, S
AF Brown, Melanie L
   Rojas, Enrique
   Gouda, Suzanne
TI A Mind-Body Approach to Pediatric Pain Management.
SO Children (Basel, Switzerland)
LA English
DT Review
DE acupuncture; hypnosis; meditation; mind–body medicine; pain management; pediatrics; yoga
AB Pain is a significant public health problem that affects all populations and has 
   significant financial, physical and psychological impact. Opioid medications, 
   once the mainstay of pain therapy across the spectrum, can be associated with 
   significant morbidity and mortality. Centers for Disease and Control (CDC) 
   guidelines recommend that non-opioid pain medications are preferred for chronic 
   pain outside of certain indications (cancer, palliative and end of life care). 
   Mindfulness, hypnosis, acupuncture and yoga are four examples of mind-body 
   techniques that are often used in the adult population for pain and symptom 
   management. In addition to providing significant pain relief, several studies 
   have reported reduced use of opioid medications when mind-body therapies are 
   implemented. Mind-body medicine is another approach that can be used in children 
   with both acute and chronic pain to improve pain management and quality of life.
C1 Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA erojas@peds.bsd.uchicago.edu (E.R.). melanie.brown@childrensmn.org.
   Department of Pain, Palliative Care and Integrative Medicine, Children's 
   Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA erojas@peds.bsd.uchicago.edu (E.R.). erojas@peds.bsd.uchicago.edu.
   Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA erojas@peds.bsd.uchicago.edu (E.R.). Suzanne.Gouda@uchospitals.edu.
NR 0
TC 0
SN 2227-906
EI 2227-906
J9 Children (Basel)
PD JUN 21
PY 2017
VL 4
IS 6
BP 
EP 
DI 10.3390/children4060050 
PG 0
UT PubMed:28632194
PM 28632194
DA 2017-06-21
ER

PT J
AU Chang, TJ
   Chien, LY
AF Chang, Tsui-Ju
   Chien, Li-Yu
TI [Evidence-Based Knowledge Transition: An Integrative Nursing Experience With 
SO Hu li za zhi The journal of nursing
LA chi
DT Journal Article
DE chemotherapy-induced peripheral neuropathy (CIPN); evidence-based knowledge transition; integrative nursing; rectal cancer
AB Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of 
   oxaliplatin in colorectal cancer patients that may impact both physical and 
   mental well-being significantly. When Western medical care alone is unable to 
   satisfy patient needs, integrative care combining traditional Chinese and Western 
   medicine approaches is an alternative option. This article shares the integrative 
   care experience of a post-operative rectal cancer patient who suffered from 
   chemotherapy-induced peripheral neuropathy. An intervention that followed a 
   holistic assessment approach in traditional Chinese medicine (TCM; i.e., 
   observation, auscultation, inquiry, and pulse feeling) combined with listening 
   and communication was conducted between April 11th and May 27th, 2022. The 
   patient's health problems were identified as chronic pain syndrome, sleep 
   disturbances, and death anxiety. During the caring process, evidence-based 
   practices were applied, the scientific literature was systematically reviewed 
   using an evidence-based approach, and an integrative care plan was developed in 
   collaboration with the medical team. Exercise, acupuncture, aromatherapy massage, 
   music, and auricular acupressure therapies were administered to reduce the 
   severity of the patient's health problems. It is hoped that this experience 
   combining evidence-based knowledge with integrative care offers a reference for 
   providing alternative patient care in a broad range of clinical settings.
C1 MSN, RN, Assistant Head Nurse, Department of Nursing, Taipei Chang Gung Memorial Hospital, Taiwan, ROC.
   PhD, RN, Associate Professor, Department of Nursing, Chang Gung University of Science and Technology, and Associate Research Fellow, Department of Nursing,Linko Chang Gung Memorial Hospital, Taiwan, ROC. lychien@mail.cgust.edu.tw.
NR 0
TC 0
SN 
EI 0047-262
J9 Hu Li Za Zhi
PD DEC 2
PY 2024
VL 71
IS 6
BP 109
EP 118
DI 10.6224/JN.202412_71(6).13 
PG 9
WC Humans; Peripheral Nervous System Diseases; chemically induced; Evidence-Based Nursing; Medicine, Chinese Traditional; methods; Antineoplastic Agents; adverse effects
UT PubMed:39618141
PM 39618141
DA 2024-12-02
ER

PT J
AU Mao, Q
   Huang, B
   Zhu, D
   Wang, Y
   Xu, S
   Wu, D
   Huang, G
   Li, Z
   Chi, Z
   Chen, R
AF Mao, Qiangjian
   Huang, Biao
   Zhu, Daocheng
   Wang, Yuqing
   Xu, Shiqi
   Wu, Desheng
   Huang, Guomin
   Li, Ziru
   Chi, Zhenhai
   Chen, Rixin
TI A Bibliometric Analysis of Acupuncture Therapy in the Treatment of 
SO Journal of pain research
LA English
DT Review
DE CiteSpace; acupuncture therapy; bibliometrics; musculoskeletal pain
AB BACKGROUND: Acupuncture therapy has been widely used in the treatment of 
   musculoskeletal pain (MP) in many countries around the world. However, there are 
   no bibliometric studies on acupuncture therapy for MP. Therefore, the aim of this 
   study was to analyze the current status, frontiers and hot spots in the use of 
   acupuncture therapy for the treatment of MP. METHODS: Literature on acupuncture 
   therapy for MP was extracted from the Web of Science Core Collection database 
   from 2003 to 2022. CiteSpace 6.2.R4 (64-bit) software was used to analyze the 
   number and centrality of journals, countries, institutions, authors, references 
   and keywords, and the functions of co-occurrence and clustering were applied to 
   draw a visual knowledge map. RESULTS: Over the past 20 years, the annual journal 
   publications have been on a steady upward trend, with 438 articles published in 
   143 journals, including Acupuncture in Medicine Journal published the most (28, 
   6.39%), JAMA-Journal of the American Medical Association was the journal with the 
   highest impact factor (IF = 120.7003), USA dominated with the most publications 
   (140, 31.96%) among 44 countries, and among 196 research organizations Kyung Hee 
   University was the most prolific (19, 4.34%) and Ha, In-Hyuk was the most 
   published author (9, 2.05%). "Acupuncture" is the most popular and highly sought 
   after keywords. "Low back pain" is the keyword with the highest centrality. 
   CONCLUSION: This article provides the current situation of the use of acupuncture 
   therapy in the treatment of MP in the past 20 years, and statistical analysis 
   reveals that "low back pain", "knit osteoporosis" and "break cancer" are new 
   research diseases related to acupuncture therapy for MP, and "myobasic trigger 
   point" is a new research direction of acupuncture therapy for MP. Therefore, this 
   study helps researchers grasp the research hotspots and provide certain 
   references for in-depth research and future topic selection.
C1 The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
   Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
   Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
   The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD NOV 29
PY 2023
VL 16
IS 
BP 3853
EP 3870
DI 10.2147/JPR.S431689 
PG 17
UT PubMed:38026461
PM 38026461
DA 2023-11-29
ER

PT J
AU Mao, JJ
AF Mao, Jun J
TI Oncology Acupuncture: Precision Medicine Meets Patient-Centered Care.
SO Medical acupuncture
LA English
DT Journal Article
DE acupuncture; hot flashes; insomnia; oncology; pain; precision medicine
AB The Precision Medicine Initiative of 2015, together with a growing focus on 
   patient-centered care, has challenged the U.S. health care system to provide the 
   correct treatment to the correct individual patient rather than to a collective 
   population. This demonstrates that acupuncture-with its history as an 
   individualized therapy and with growing evidence-based clinical findings-is the 
   ideal model for personalized medicine within oncology care. The current author 
   and colleagues used previously conducted oncology acupuncture trials for pain, 
   hot flashes, and insomnia to demonstrate that precise delivery of acupuncture 
   might depend on a patient's genetics. Individual preferences and perceived 
   evidence surrounding treatments might also factor into patient treatment choices. 
   Further effectiveness evidence comparing acupuncture to drugs or 
   cognitive-behavioral therapy provides insight on the relative benefit or harm of 
   each treatment, which, in turn, can help clinicians and patients to choose the 
   best treatment plans centered on patients' goals. To advance precision oncology 
   acupuncture research, appropriate biomarkers and psychologic attributes should be 
   incorporated into adequately powered and well-designed clinical trials to 
   evaluate how acupuncture can be delivered to the correct patients.
C1 Bendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD DEC 29
PY 2020
VL 32
IS 6
BP 405
EP 407
DI 10.1089/acu.2020.1501 
PG 2
UT PubMed:33362901
PM 33362901
DA 2020-12-29
ER

PT J
AU Rossi, E
   Di, Stefano M
   Firenzuoli, F
   Monechi, MV
   Baccetti, S
AF Rossi, Elio
   Di Stefano, Mariella
   Firenzuoli, Fabio
   Monechi, Maria Valeria
   Baccetti, Sonia
TI Add-On Complementary Medicine in Cancer Care: Evidence in Literature and 
SO Medicines (Basel, Switzerland)
LA English
DT Review
DE cancer care; complementary medicines (CM); evidence in literature; integration in public health service
AB Background: According to the literature an increasing number of cancer patients 
   demand for complementary therapies during their disease. Research has 
   demonstrated that some of these therapies are effective and safe as adjunctive 
   treatments in specific symptoms of these patients. Methods: The aims of the paper 
   are to review the main and recent papers of international literature on the 
   effectiveness of complementary medicine (CM) therapies on side effects of 
   anti-cancer protocols and improvement in the quality of life of oncological 
   patients, and to describe the integration of evidence-based acupuncture, herbal 
   medicine and homeopathy treatments in Public Cancer Network of the region of 
   Tuscany. Results: After the review of literature and the approval of a Regional 
   Resolution, some CM will be introduced in Cancer Departments in Tuscany to 
   additionally treat cancer-related symptoms and side effects of conventional 
   cancer therapy: acupuncture for nausea and post-chemotherapy and post-surgery 
   vomiting, pain, hot flashes of iatrogenic menopause, xerostomia; homeopathy for 
   hot flashes of iatrogenic menopause and the side effects of radiotherapy; herbal 
   medicine for cancer-related fatigue, nausea and vomiting, pain, mucositis, 
   anxiety, and depression. Conclusions: The integration of evidence-based 
   complementary treatments allows for an effective response to the demand coming 
   from cancer patients and combines safety and equity of access in public health 
   systems.
C1 Tuscan Network of Integrative Medicine (TNIM), Regione Toscana, Assessorato al Diritto alla Salute, al Welfare e all'Integrazione socio-sanitaria, DirezioneDiritti di cittadinanza e coesione sociale, Via Taddeo Alderotti 26/N, Firenze50139, Italy. e.rossi@mednat.it.
   Tuscan Network of Integrative Medicine (TNIM), Regione Toscana, Assessorato al Diritto alla Salute, al Welfare e all'Integrazione socio-sanitaria, DirezioneDiritti di cittadinanza e coesione sociale, Via Taddeo Alderotti 26/N, Firenze50139, Italy. m.distefano@mednat.it.
   Tuscan Network of Integrative Medicine (TNIM), Regione Toscana, Assessorato al Diritto alla Salute, al Welfare e all'Integrazione socio-sanitaria, DirezioneDiritti di cittadinanza e coesione sociale, Via Taddeo Alderotti 26/N, Firenze50139, Italy. fabio.firenzuoli@unifi.it.
   Tuscan Network of Integrative Medicine (TNIM), Regione Toscana, Assessorato al Diritto alla Salute, al Welfare e all'Integrazione socio-sanitaria, DirezioneDiritti di cittadinanza e coesione sociale, Via Taddeo Alderotti 26/N, Firenze50139, Italy. valeriamonechi@gmail.com.
   Tuscan Network of Integrative Medicine (TNIM), Regione Toscana, Assessorato al Diritto alla Salute, al Welfare e all'Integrazione socio-sanitaria, DirezioneDiritti di cittadinanza e coesione sociale, Via Taddeo Alderotti 26/N, Firenze50139, Italy. sonia.baccetti@uslcentro.toscana.it.
NR 0
TC 0
SN 2305-632
EI 2305-632
J9 Medicines (Basel)
PD SEP 21
PY 2017
VL 4
IS 1
BP 
EP 
DI 10.3390/medicines4010005 
PG 0
UT PubMed:28930222
PM 28930222
DA 2017-09-21
ER

PT J
AU Wang, X
   Shen, Q
   Hu, X
   Liang, Y
AF Wang, Xiaoying
   Shen, Qiongying
   Hu, Xinyi
   Liang, Yi
TI Comment on 'Efficacy and Safety of Different Acupuncture Treatments for 
SO Integrative cancer therapies
LA English
DT Letter
NR 0
TC 0
SN 1552-695
EI 1534-735
J9 Integr Cancer Ther
PD MAY 26
PY 2025
VL 24
IS 
BP 15347354251344281
EP 15347354251344281
DI 10.1177/15347354251344281 
PG 1
UT PubMed:40417861
PM 40417861
DA 2025-05-26
ER

PT J
AU Williams, JE
   Kim, Y
   Moramarco, J
AF Williams, James E
   Kim, Yun
   Moramarco, Jacques
TI Research Supports the Integration of Acupuncture in Mainstream Health Care for 
SO Medical acupuncture
LA English
DT Journal Article
DE acupuncture; acupuncture-physician (AP); acupuncturist; biopuncture; doctor of acupuncture and herbal medicine (DAHM); doctor of oriental medicine (DOM/OMD); integrative therapies; medical acupuncture; medical doctor (MD); osteopathic doctor (DO); translational research
AB PURPOSE: To address the role of acupuncture in mainstream health care for symptom 
   relief, condition outcome, pain management, and shared therapy in resolving 
   chronic diseases. This article explores how acupuncture education can adapt to 
   meet the standards required for inclusion in conventional health care. 
   OBJECTIVES: To discuss the future of acupuncture education and its part in 
   training providers for inclusion in a comprehensive health care system that 
   involves physician acupuncturists and licensed acupuncturists for treating and 
   managing specific chronic diseases. To strategize the future of acupuncture 
   education at an advanced clinical level that fosters incorporating acupuncture 
   therapy into selected allopathic settings. To encourage the recognition of 
   translational research for promoting the acceptance of acupuncture by providers 
   and insurers. CONCLUSION: Translational research employs clinical evidence to 
   support acupuncture therapy when incorporated into selected areas of allopathic 
   practices, including pain management, palliative care for patients with end-stage 
   cancer, sleep disorders, anxiety disorders, post-traumatic stress, female 
   hormonal conditions such as premenstrual syndrome and menopausal syndrome, as 
   well as chronic fatigue syndromes including Myalgic encephalomyeltitis/chronic 
   fatigue syndrome (ME/CFS) and Long COVID. Advanced clinical training in 
   acupuncture schools and postgraduate certification courses are required to 
   prepare acupuncturists to safely and effectively provide the specialized 
   integrative acupuncture services needed in these clinical areas.
C1 Emperor's College, Culver City, CA, USA.
   Emperor's College, Culver City, CA, USA.
   Emperor's College, Culver City, CA, USA.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD MAY 1
PY 2025
VL 37
IS 2
BP 106
EP 111
DI 10.1089/acu.2024.0108 
PG 5
UT PubMed:40308724
PM 40308724
DA 2025-05-01
ER

PT J
AU Berberian, P
   Obimba, C
   Glickman-Simon, R
   Sethi, T
AF Berberian, Peter
   Obimba, Chinyere
   Glickman-Simon, Richard
   Sethi, Tanmeet
TI Herbs for Low-Back Pain, Acupuncture for Psychological Distress, Osteopathic 
SO Explore (New York, N.Y.)
LA English
DT Journal Article
NR 0
TC 0
SN 1878-754
EI 
J9 Explore (NY)
PD AUG 5
PY 2015
VL 11
IS 5
BP 410
EP 4
DI 10.1016/j.explore.2015.07.011 
PG -406
UT PubMed:26238168
PM 26238168
DA 2015-08-05
ER

PT J
AU Hao, YB
   Liu, YL
   Wang, XM
   Cheng, K
   Tu, QY
   Dai, F
   Yang, XB
AF Hao, Ya-Bo
   Liu, Yan-Lin
   Wang, Xiao-Mei
   Cheng, Kai
   Tu, Qing-Yu
   Dai, Fei
   Yang, Xi-Bing
TI Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers 
SO Neurogastroenterology and motility
LA English
DT Journal Article
DE Zusanli; electroacupuncture; inflammatory biomarkers; visceral hypersensitivity; visceral pain
AB BACKGROUND: Irritable bowel syndrome (IBS) is characterized by recurrent visceral 
   pain associated with low-grade gut inflammation. Electroacupuncture (EA) at 
   acupoint ST36 (Zusanli) is reputed to alleviate gastrointestinal disorders, but 
   its effects on IBS-related visceral hypersensitivity and inflammation remain to 
   be fully elucidated. This study evaluated whether EA at ST36 attenuates visceral 
   pain and modulates key inflammatory mediators in the IBS rat model. METHODS: 
   Forty male rats were randomly assigned to Control, IBS model, IBS + EA, and 
   IBS + Sham groups (n = 10 each). IBS was induced by intracolonic acetic acid 
   enema combined with daily restraint stress for 1 week, validating the IBS-D 
   model. EA was applied at bilateral ST36 (2/100 Hz alternating frequency, ~0.5 mA, 
   20 min) every other day for 2 weeks; sham treatment used superficial needling 
   with no electrical current. Visceral pain was assessed by abdominal withdrawal 
   reflex (AWR) scores and electromyographic responses to graded colorectal 
   distension. Colonic tissues were analyzed for pro-inflammatory cytokines 
   (interleukin-1β, IL-6, tumor necrosis factor-α) by ELISA and for the expression 
   of pain or inflammation-related proteins (TRPV1 and nuclear factor kappa B, 
   NF-κB) by Western blot analyses. RESULTS: IBS model rats exhibited pronounced 
   visceral hypersensitivity, with AWR scores significantly elevated (e.g., score 3 
   threshold volume reduced by ~40% vs. controls, p < 0.01). EA at ST36 markedly 
   alleviated visceral pain, increasing pain threshold and reducing AWR scores by 
   ~30%-50% compared to untreated IBS (p < 0.05). EA also significantly 
   downregulated colonic IL-1β, IL-6, and TNF-α levels (by 45%-60% vs. IBS, 
   p < 0.01) and reduced TRPV1 and NF-κB expression toward normal levels. 
   CONCLUSION: EA at ST36 produced significant analgesic and anti-inflammatory 
   effects in IBS model rats. Visceral hypersensitivity was blunted and colonic 
   inflammatory biomarkers (cytokines, TRPV1, NF-κB) were suppressed by EA, 
   suggesting that EA at ST36 modulates neuro-immune pathways to relieve IBS-related 
   pain. These findings support the therapeutic potential of ST36-targeted 
   electroacupuncture for managing IBS visceral pain via inflammatory mechanism 
   attenuation.
C1 Acupuncture and Moxibustion Department, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China.
   Acupuncture and Moxibustion Department, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China.
   Acupuncture and Moxibustion Department, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China.
   Pediatrics Department, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China.
   Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China.
   Division of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
   Acupuncture and Moxibustion Department, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China.
NR 0
TC 0
SN 1365-298
EI 
J9 Neurogastroenterol Motil
PD DEC 19
PY 2025
VL 0
IS 
BP e70195
EP e70195
DI 10.1111/nmo.70195 
PG 1
UT PubMed:41413920
PM 41413920
DA 2025-12-19
ER

PT J
AU Chen, R
   Li, M
   Ding, M
AF Chen, Rong
   Li, Meng
   Ding, Mingxing
TI Optogenetic stimulation of the "Zusanli" acupoint alleviates inflammatory pain 
SO Heliyon
LA English
DT Journal Article
AB Inflammatory pain, an important form of common pain, negatively influences the 
   quality of life. Pathway-selective optogenetic control is a popular tool in 
   neuronal function research; however, attempts to modulate rodent behavior using 
   pathway-selective optogenetics remain unverified. We developed a methodology for 
   pathway-selective optogenetics in rats, focusing on the delivery of recombinant 
   adeno-associated virus (rAAV) containing channelrhodopsin-2 (ChR2) injected at 
   the "Zusanli" acupoints to the dorsal root ganglia (DRG) and toes, which is a 
   part of the complex neuron network. Optogenetic stimulation of gamma-aminobutyric 
   acid (GABA) projections to the "Zusanli" acupoints delivered several 
   rAAV9-GAD1-ChR2-mcherry particles to the spinal cord horn (SCDH) and DRG and few 
   rAAV9-GAD1-ChR2-mcherry particles to toes, thereby evoking an analgesic effect in 
   complete Freund's adjuvant (CFA) rats similar to those of acupuncture. 
   Furthermore, blue light stimulation (LED) and electroacupuncture (EA) reduced 
   inflammatory pain in CFA rats, as evidenced by the changes in the paw edema, paw 
   withdrawal latency (PWL), and paw withdrawal threshold (PWT) values. Further 
   exploration of the mechanisms underlying this phenomenon revealed that 
   optogenetic stimulation upregulates the decarboxylase-65 (GAD65) and 
   decarboxylase-67 (GAD67) protein levels and downregulates the levels of GABA 
   transporter-1 (GAT1) and GABA transporter-3 (GAT3) to alleviate inflammatory 
   pain. The activation of the p38 mitogen-activated protein kinases (MAPK) and Wnt 
   signal transduction pathways decreased the release of interleukin 6 (IL-6), 
   interleukin 10 (IL-10), and tumor necrosis factor-α (TNFα). These findings 
   indicate that optogenetic stimulation of the "Zusanli" acupoint alleviated 
   inflammatory pain.
C1 College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
   College of Animal Science and Technology, Tarim University, Alar, Xinjiang, 
   College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
   College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
NR 0
TC 0
SN 2405-844
EI 2405-844
J9 Heliyon
PD NOV 18
PY 2024
VL 10
IS 21
BP e39992
EP e39992
DI 10.1016/j.heliyon.2024.e39992 
PG 1
UT PubMed:39553603
PM 39553603
DA 2024-11-18
ER

PT J
AU Lu, W
   Matulonis, UA
   Dunn, JE
   Lee, H
   Doherty-Gilman, A
   Dean-Clower, E
   Goodman, A
   Davis, RB
   Buring, J
   Wayne, P
   Rosenthal, DS
   Penson, RT
AF Lu, Weidong
   Matulonis, Ursula A
   Dunn, Julie E
   Lee, Hang
   Doherty-Gilman, Anne
   Dean-Clower, Elizabeth
   Goodman, Annekathryn
   Davis, Roger B
   Buring, Julie
   Wayne, Peter
   Rosenthal, David S
   Penson, Richard T
TI The Feasibility and Effects of Acupuncture on Quality of Life Scores During 
SO Medical acupuncture
LA English
DT Journal Article
DE Acupuncture; Chemotherapy; EORTC; Neutropenia; Ovarian Cancer; Quality of Life; Randomized Controlled Trial
AB BACKGROUND: Within a pilot trial regarding chemotherapy-induced neutropenia, the 
   secondary aim of the main study was explored. This involved measuring the 
   effects-as shown on two key measurement scales reflecting quality of life 
   (QoL)-of verum versus sham acupuncture on patients with ovarian cancer during 
   chemotherapy. OBJECTIVE: The aim of this substudy was to determine the 
   feasibility of determining the effects of verum acupuncture versus sham 
   acupuncture on QoL in patients with ovarian cancer during chemotherapy. DESIGN: 
   This was a randomized, sham-controlled trial. SETTING: The trial was conducted at 
   two cancer centers. PATIENTS: Patients with ovarian cancer (N=21) who were 
   receiving chemotherapy-primarily intravenous carboplatin and 
   paclitaxel-participated in this substudy. INTERVENTION: The participants were 
   given either active or sham acupuncture 1 week prior to cycle 2 of chemotherapy. 
   There were ten sessions of acupuncture, with manual and electro-stimulation over 
   a 4-week period. MAIN OUTCOME MEASURES: The European Organization for Research 
   and Treatment of Cancer-Quality-of-Life Questionnaire-Core 30 Item 
   (EORTC-QLQ-C30) and the Quality of Life Questionnaire-Ovarian Cancer Module-28 
   Item (QLQ-OV28) were administered to the patients at baseline and at the end of 
   their acupuncture sessions. RESULTS: Of the original 21, 15 patients (71%) 
   completed the study, and 93% of them completed the questionnaires. The 
   EORTC-QLQ-C30 subscores were improved in the acupuncture arm, including the mean 
   scores of social function (SF), pain, and insomnia (p=0.05). However, after 
   adjusting for baseline differences, only the SF score was significantly higher in 
   the active acupuncture arm, compared with the sham acupuncture arm (p=0.03). 
   CONCLUSIONS: It appears feasible to conduct a randomized sham-controlled 
   acupuncture trial measuring QoL for patients with ovarian cancer who are 
   undergoing chemotherapy. Acupuncture may have a role in improving QoL during 
   chemotherapy.
C1 Leonard P. Zakim Center for Integrative Therapies, Dana-Farber Cancer Institute , Boston, MA. 
   The New England School of Acupuncture , Newton, MA.
   Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, MA.
   The New England School of Acupuncture , Newton, MA.
   Biostatistics Center, Massachusetts General Hospital , Boston, MA.
   Leonard P. Zakim Center for Integrative Therapies, Dana-Farber Cancer Institute , Boston, MA.
   Leonard P. Zakim Center for Integrative Therapies, Dana-Farber Cancer Institute , Boston, MA.
   Department of Gynecologic Oncology & Medicine, Massachusetts General Hospital , Boston, MA.
   Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital , Boston, MA.
   Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital , Boston, MA.
   Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital , Boston, MA.
   Leonard P. Zakim Center for Integrative Therapies, Dana-Farber Cancer Institute , Boston, MA.
   Department of Gynecologic Oncology & Medicine, Massachusetts General Hospital , Boston, MA.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD DEC 1
PY 2012
VL 24
IS 4
BP 233
EP 240
DI 10.1089/acu.2012.0904 
PG 7
UT PubMed:24761165
PM 24761165
DA 2012-12-01
ER

PT J
AU Li, Z
   Gao, Y
   Yan, D
   Feng, YH
AF Li, Zhe
   Gao, Yu
   Yan, Dong
   Feng, Yi-Hui
TI Efficacy of electroacupuncture for cervical spondylosis-related pain in patients 
SO World journal of psychiatry
LA English
DT Journal Article
DE Cervical spondylosis; Electroacupuncture; Generalized anxiety disorder; Neuroinflammation; Pain management
AB BACKGROUND: Cervical spondylosis (CS) frequently co-occurs with generalized 
   anxiety disorder (GAD), presenting a complex clinical challenge. Managing 
   CS-related pain in patients with GAD is particularly challenging because of the 
   bidirectional relationship between pain and anxiety, necessitating integrated 
   treatment strategies. AIM: To evaluate the efficacy of electroacupuncture (EA) in 
   treating CS-related pain and anxiety in patients with GAD. METHODS: This 
   retrospective cohort study analyzed data from 83 patients with CS-related pain 
   and GAD who received EA treatment over 2-year period. Pain intensity was assessed 
   using the visual analog scale, and anxiety symptoms were measured using the 
   Hamilton Anxiety Rating Scale. Additionally, neuroinflammatory markers, including 
   interleukin-6, tumor necrosis factor-alpha, and high-sensitivity C-reactive 
   protein, were examined. Outcomes were evaluated at baseline, after 4 weeks, and 
   after 8 weeks of treatment. RESULTS: EA treatment significantly reduced 
   CS-related pain (mean visual analog scale reduction: 3.24 ± 1.18; P < 0.001) and 
   improved anxiety symptoms (mean Hamilton Anxiety Rating Scale reduction: 7.83 ± 
   2.65; P < 0.001) after 8 weeks of treatment. Neuroinflammatory markers also 
   showed significant reductions, with interleukin-6 and tumor necrosis factor-alpha 
   levels decreasing by 32.7% and 28.5%, respectively (P < 0.01). Pain reduction was 
   significantly correlated with improvements in anxiety symptoms (r = 0.68; P < 
   0.001) and a decrease in inflammatory markers (r = 0.54; P < 0.01). CONCLUSION: 
   EA demonstrates significant efficacy in reducing CS-related pain in patients with 
   comorbid GAD, along with concurrent improvements in anxiety symptoms and 
   neuroinflammatory profiles. These findings suggest that EA may offer a valuable 
   integrative approach for managing this complex clinical presentation, potentially 
   addressing both pain and anxiety through the modulation of neuroinflammatory 
   pathways.
C1 Department of Pain Disease Treatment, Zhengzhou Orthopaedic Hospital, Zhengzhou 450052, Henan Province, China.
   Department of Cervicolumbar, Zhengzhou Orthopaedic Hospital, Zhengzhou 450052, Henan Province, China.
   Department of Cervicolumbar, Zhengzhou Orthopaedic Hospital, Zhengzhou 450052, Henan Province, China.
   Department of Acupuncture and Moxibustion, University of Health and Rehabilitation Sciences, Qingdao 266042, Shandong Province, China.walgzzh@126.com.
NR 0
TC 0
SN 2220-320
EI 2220-320
J9 World J Psychiatry
PD NOV 24
PY 2025
VL 15
IS 11
BP 108288
EP 108288
DI 10.5498/wjp.v15.i11.108288 
PG 0
UT PubMed:41281520
PM 41281520
DA 2025-11-24
ER

PT J
AU DeMoss, P
   Ramsey, LH
   Karlson, CW
AF DeMoss, Patrick
   Ramsey, Logan H
   Karlson, Cynthia Windham
TI Phantom Limb Pain in Pediatric Oncology.
SO Frontiers in neurology
LA English
DT Review
DE adolescent; amputation; cancer; children; pediatrics; phantom limb pain; therapy; treatment
AB Phantom limb pain (PLP) is a prevalent problem for children and adolescents 
   undergoing amputation due to cancer treatment. The symptoms are wide ranging from 
   sharp to tingling. PLP in children typically lasts for a few minutes but can be 
   almost constant and can be highly distressing. This focused review describes the 
   characteristics, epidemiology, mechanisms, and evidence-based treatment of PLP in 
   pediatric populations, focusing on pediatric cancer. In pediatric oncology, the 
   administration of chemotherapy is a risk factor that potentially sensitizes the 
   nervous system and predisposes pediatric cancer patients to develop PLP after 
   amputation. Gabapentin, tricyclic antidepressants, opiates, nerve blocks, and 
   epidural catheters have shown mixed success in adults and case reports document 
   potential utility in pediatric patients. Non-pharmacologic treatments, such as 
   mirror therapy, psychotherapy, and acupuncture have also been used in pediatric 
   PLP with success. Prospective controlled trials are necessary to advance care for 
   pediatric patients with PLP.
C1 Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, United States.
   School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.
   Division of Hematology/Oncology, Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, United States.
NR 0
TC 0
SN 1664-229
EI 1664-229
J9 Front Neurol
PD APR 25
PY 2018
VL 9
IS 
BP 219
EP 219
DI 10.3389/fneur.2018.00219 
PG 0
UT PubMed:29686645
PM 29686645
DA 2018-04-25
ER

PT J
AU Viel, E
   Truong, D
   Rambach, L
   Guinet, F
   Vanoli, A
   Schipman, B
   Harami, D
AF Viel, Erika
   Truong, David
   Rambach, Laurie
   Guinet, François
   Vanoli, André
   Schipman, Benjamin
   Harami, Djamel
TI Efficacy of Auricular Acupuncture in Chemotherapy-Induced Peripheral Neuropathy: 
SO Medical acupuncture
LA English
DT Journal Article
DE auricular acupuncture; auriculotherapy; cancer; chemotherapy-induced peripheral neuropathy; neuropathy
AB Background: Chemotherapy-induced peripheral neuropathy (CIPN) can adversely 
   affect completion of systemic anticancer treatment and cause long-term morbidity. 
   To date, its physiopathology remains unclear, and treatments are rare and poorly 
   performed. Auricular acupuncture has already offered interesting results in 
   several symptoms. Objective: This study (AACIPN2020) assessed the efficacy of 
   auriculotherapy in CIPN. Design: We used patients' systematically collected data 
   of 2014-2016 in a medical oncology practice. The treatment was made according to 
   guidelines of the interuniversity diploma and the cartography of the World Health 
   Organization. Pain assessment according to the Common Terminology Criteria for 
   Adverse Event scale was orally collected. Results: Seventy-three cancer patients 
   were treated for CIPN. They had finished chemotherapy 24 weeks prior on average. 
   They received on average 23 punctures at each appointment. Sixty-five percent of 
   patients met satisfaction, with 31% with a real impact on their daily life. 
   Efficacy appeared after one or two treatments for 96% of cases. Some patients 
   continued treatment to maximize benefits. Conclusions: Auricular acupuncture is a 
   safe and inexpensive method of CIPN treatment. It may be applied earlier in 
   chemotherapy administration, and in a large variety of other symptoms. Clinical 
   trial registration number: COS RGDS 2019 09 001.
C1 Medical Oncology, Ramsay Générale de Santé, Hopital Privé Sainte Marie, Chalon-sur-Saône, France.
   Centre Georges-François Leclerc, Dijon, France.
   Toussus-Le-Noble, France.
   Medical Oncology, Centre Hospitalier William Morey, Chalon-sur-Saône, France.
   Medical Oncology, Centre Hospitalier Galuzot, Montceau Les Mines, France.
   Medical Oncology, Ramsay Générale de Santé, Hopital Privé Sainte Marie, Chalon-sur-Saône, France.
   Radiotherapy, Institut de Cancérologie de Bourgogne, Chalon-sur-Saône, France.
   Oncology Department, Chalon-sur-Saône, France.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD JAN 11
PY 2022
VL 33
IS 3
BP 212
EP 218
DI 10.1089/acu.2020.1506 
PG 6
UT PubMed:35003493
PM 35003493
DA 2022-01-11
ER

PT J
AU Cha, MH
   Nam, TS
   Kwak, Y
   Lee, H
   Lee, BH
AF Cha, Myeoung Hoon
   Nam, Taick Sang
   Kwak, Yongho
   Lee, Hyejung
   Lee, Bae Hwan
TI Changes in cytokine expression after electroacupuncture in neuropathic rats.
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB The production of proinflammatory cytokines including interleukin-1 (IL-1), 
   interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) plays a key role in 
   chronic pain such as neuropathic pain. We investigated changes in cytokine 
   expression in injured peripheral nerves and dorsal root ganglia (DRG) following 
   electroacupuncture (EA) treatment. Neuropathic pain was induced by peripheral 
   nerve injury to the left hind limb of Sprague-Dawley rats under pentobarbital 
   anesthesia. Two weeks later, the nerve-injured rats were treated by EA for 10 
   minutes. The expression levels of IL-1β, IL-6, and TNF-α in peripheral nerves and 
   DRG of neuropathic rats were significantly increased in nerve-injured rats. 
   However, after EA, the cytokine expression levels were noticeably decreased in 
   peripheral nerves and DRG. These results suggest that EA stimulation can reduce 
   the levels of proinflamtory cytokines elevated after nerve injury.
C1 Department of Physiology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, P.O. Box 8044, Seoul 120-752, Republic of Korea.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD MAR 29
PY 2012
VL 2012
IS 
BP 792765
EP 792765
DI 10.1155/2012/792765 
PG 0
UT PubMed:22454684
PM 22454684
DA 2012-03-29
ER

PT J
AU McDonald, JL
   Bauer, M
AF McDonald, John L
   Bauer, Matthew
TI Is Electroacupuncture Contraindicated for Preventing and Treating 
SO Medical acupuncture
LA English
DT Review
DE CIPN; EA; chemotherapy-induced peripheral neuropathy; conflicting evidence; electroacupuncture
AB BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common 
   side-effect of several drugs used to combat cancer. Thus, researchers have sought 
   better treatments for and prevention of CIPN, such as electroacupuncture (EA). 
   Some trials show EA worsens or prolongs CIPN pain and recommend against further 
   studies on this. This narrative review explores EA for preventing or treating 
   CIPN, comparing positive and negative outcomes. METHODS: PubMed, ScienceDirect, 
   and Google Scholar were searched for electroacupuncture, CIPN, and peripheral 
   neuropathy. A snowballing method was used to find systematic reviews and studies 
   in systematic reviews. RESULTS: Seven English-language trials were found on using 
   EA for preventing or treating CIPN. In 3 prevention studies, 1 had significant 
   benefits, 1 had modest benefits, and 1 had worse pain in an EA group at 
   follow-up, compared to sham controls. In 4 treatment studies, 2 had significant 
   benefits, 1 had no difference from 3 controls, and 1 had sham control was 
   superior to verum EA. CONCLUSIONS: Most of the studies were limited by small 
   sample sizes, and some studies used EA protocols and treatment doses (frequency 
   and total number of sessions) that were potentially suboptimal. The quantity and 
   quality of the studies are insufficient to draw firm conclusions on effectiveness 
   and safety. More studies must test optimal EA protocols and treatment dosages. It 
   is inappropriate to say that EA is not recommended for CIPN prevention or 
   treatment, because there is no robust evidence to justify this. Generally, 
   research has found benefits and no harms.
C1 Department of Chinese Medicine, Endeavour College of Natural Health, Southport, Queensland, Australia.
   Acupuncture New Foundation, La Verne, CA, USA.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD JAN 2
PY 2024
VL 35
IS 6
BP 290
EP 295
DI 10.1089/acu.2023.0085 
PG 5
UT PubMed:38162553
PM 38162553
DA 2024-01-02
ER

PT J
AU McMahon, D
   Kadiyala, S
   Estores, IM
AF McMahon, David
   Kadiyala, Sushma
   Estores, Irene M
TI Acupuncture, Shingles, and Allergen Immunotherapy.
SO Medical acupuncture
LA English
DT Journal Article
DE dermatologic conditions; musculoskeletal pain; neurological disorders
AB Background: The Varicella-zoster virus (VZV) remains dormant in the dorsal root 
   ganglia and can become reactive later in a person's life. Factors such as stress, 
   trauma, chronic disease, systemic illness, immune disorders, and age-related 
   decline in host immunologic responses can potentially incite reactivation. 
   Activation of VZV resulting in shingles following acupuncture has been reported 
   in the literature previously, and some mechanisms have been proposed for this 
   observation. Case: A patient with a history of total thyroidectomy for thyroid 
   cancer presented with chronic neck pain. She was clinically and biochemically in 
   a euthyroid state and on thyroid replacement therapy. She had a history of 
   chickenpox, at age 13, and seasonal allergies. After her first acupuncture 
   session, she received an allergy shot for her seasonal allergies. A day after the 
   procedure, she developed a vesicular rash and was subsequently diagnosed with 
   acute Herpes zoster. Subsequent acupuncture was withheld following this event. 
   She received acyclovir and applied topical Aloe vera to the cutaneous lesions, 
   and developed mild scarring, but did not experience postherpetic neuralgia. 
   Conclusions: Acupuncture is a minor trauma that can predispose a patient to 
   reactivation of VZV and shingles in the setting of immune activation with 
   allergen immunotherapy.
C1 Integrative Medicine Program and University of Florida Health, Gainsville, Florida, USA.
   Division of Endocrinology, University of Florida Health, Gainsville, Florida, USA.
   Integrative Medicine Program and University of Florida Health, Gainsville, Florida, USA.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD JAN 4
PY 2022
VL 33
IS 6
BP 443
EP 446
DI 10.1089/acu.2020.1521 
PG 3
UT PubMed:34976278
PM 34976278
DA 2022-01-04
ER

PT J
AU Lin, HC
   Hsu, HC
   Liao, HY
   Chen, ALP
   Lin, YW
AF Lin, Huan-Chin
   Hsu, Hsin-Cheng
   Liao, Hsien-Yin
   Chen, Arbee L P
   Lin, Yi-Wen
TI Electroacupuncture Modulates Programmed Cell Death 1 Ligand 1 on Peripheral and 
SO Biomedicines
LA English
DT Journal Article
DE PD-L1; TRPV1; electroacupuncture; fibromyalgia; somatosensory cortex; spinal cord
AB Background: Fibromyalgia, a chronic condition that causes long-lasting pain over 
   several months, is a global medical issue with both personal and societal 
   implications. It is one of the hardest types of pain to heal, given the lack of 
   objective parameters for diagnosis and progression evaluation. The main symptoms 
   of fibromyalgia are long-lasting widespread pain alongside with anxiety, fatigue, 
   sleep disorders, cognitive dysfunction, and obesity. Programmed cell death 1 
   ligand 1 (PD-L1) has been used as a target in cancer immunotherapy. It can 
   inhibit acute and chronic pain by suppressing nociceptive neuron activity via 
   PD-1 receptors. Methods: The current study aimed to investigate the role of 
   PD-L1/PD1 in a mouse fibromyalgia pain model. Mice were exposed to intermittent 
   cold stress (ICS) to produce a murine fibromyalgia model characterized using von 
   Frey and Hargreaves tests. Results: The ICS-induced mice fibromyalgia pain model 
   showed mechanical (2.26 ± 0.18 g) and thermal (4.36 ± 0.31 s) hyperalgesia. 
   Nociceptive responses could be relieved with electroacupuncture, intracerebral 
   PD-L1 injection, or Trpv1 deletion. We also identified a lower PD-1 level in the 
   dorsal root ganglion, spinal cord, thalamus, and somatosensory cortex. In 
   contrast, levels of pain-related kinases increased after fibromyalgia induction, 
   an effect which could be reversed by EA, PD-L1, or Trpv1 deletion. Conclusions: 
   Our findings shed light on the contribution of PD-L1/PD1 to EA and fibromyalgia 
   pain, indicating its potential as a treatment target for fibromyalgia.
C1 College of Chinese Medicine, Graduate Institute of Acupuncture Science, China Medical University, Taichung 404328, Taiwan.
   Department of Traditional Chinese Medicine, Feng Yuan Hospital, Ministry of 
   Department of Traditional Chinese Medicine, China Medical University Hsinchu Hospital, China Medical University, Hsinchu 302056, Taiwan.
   College of Chinese Medicine, School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 404328, Taiwan.
   Department of Computer Science and Information Engineering, Asia University, Taichung 413305, Taiwan.
   College of Chinese Medicine, Graduate Institute of Acupuncture Science, China Medical University, Taichung 404328, Taiwan.
   Chinese Medicine Research Center, China Medical University, Taichung 404328, 
NR 0
TC 0
SN 2227-905
EI 2227-905
J9 Biomedicines
PD FEB 26
PY 2025
VL 13
IS 2
BP 
EP 
DI 10.3390/biomedicines13020396 
PG 0
UT PubMed:40002809
PM 40002809
DA 2025-02-26
ER

PT J
AU Xi, Z
   Wei, X
   Ye, Z
   Wang, K
   Zhou, J
AF Xi, Ziqi
   Wei, Xuqiang
   Ye, Zi
   Wang, Ke
   Zhou, Jia
TI Acupuncture for adult lung cancer of patient-reported outcomes: A systematic 
SO Frontiers in oncology
LA English
DT Journal Article
DE PROs = patient-reported outcomes; acupuncture; lung cancer; meta-analysis; systematic review
AB PURPOSE: This systematic review and meta-analysis aims to assess the effects of 
   acupuncture on patient-reported outcomes (PROs) in adults with lung cancer. 
   METHODS: Electronic databases including PubMed, Embase, Cochrane Library, Web of 
   Science, China National Knowledge Infrastructure (CNKI), China Science and 
   Technology Journal Database (CQVIP), Wanfang Data, SinoMed, and gray literatures 
   were retrieved from inception to 1 July 2022 for randomized controlled trials 
   (RCTs). Acupuncture was defined as an experimental intervention, and the patients 
   of the control groups included either treatment including conventional therapy 
   (usual care, sham/placebo acupuncture, pharmacotherapy including Western medicine 
   and Chinese traditional medicine). PROs for this study were measured by seven 
   scales of primary outcomes including the Karnofsky Performance Status (KPS), 
   European Organization for Research and Treatment of Cancer Quality of Life 
   Questionnaire, Functional Assessment of Cancer Therapy-Lung, Functional 
   Assessment of Cancer Therapy Lung Cancer Subscale, Leicester Cough Questionnaire 
   (LCQ score), the Medical Outcomes Study (MOS) item short form health survey 
   (SF-36), and the St George's Respiratory Questionnaire, and 12 scales of 
   secondary outcomes. Cochrane Collaboration's tool was used to assess the risks of 
   bias. Data were combined and analyzed with RevMan 5.4 and Stata/SE 16.0. RESULTS: 
   We retrieved 3,002 lung cancer patients from 33 trials. KPS included with 1,000 
   patients showed that acupuncture could significantly improve the quality of life 
   (QOL) compared with the control group regardless of different 
   tumor-node-metastasis stages or the different stages of disease. The study showed 
   that acupuncture significantly improved lung cancer-related symptoms in the QOL, 
   pain, nausea and vomiting, insomnia, anxiety and depression, fatigue, and 
   constipation compared with the control group. Eight RCTs reported the occurrence 
   of adverse events, whereas four reported none and four RCTs reported that the 
   events in the observation group were significantly less than those in the control 
   group. CONCLUSION: Acupuncture proved to be a promising intervention, both 
   postoperatively and after chemotherapy, and should be recommended as a beneficial 
   alternative strategy to promote PROs in lung cancer patients at all stages of 
   application. Considering the low quality, we suggest more rigorous clinical 
   trials of acupuncture for lung cancer in the future and more emphasis on the 
   effect of acupuncture in patients with lung cancer on their PROs, mainly in the 
   aspect of the QOL. SYSTEMATIC REVIEW REGISTRATION: 
   https://www.crd.york.ac.uk/prospero/display_record.php?, identifier 
   [CRD42021274122].
C1 Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, China.
   Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, China.
   Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, China.
   Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, China.
   Acupuncture Anesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD SEP 20
PY 2022
VL 12
IS 
BP 921151
EP 921151
DI 10.3389/fonc.2022.921151 
PG 0
UT PubMed:36119472
PM 36119472
DA 2022-09-20
ER

PT J
AU Chen, VE
   Greenberger, BA
   Shi, Z
   Gajjar, S
   Shi, W
   Mourad, WF
   Yan, W
AF Chen, Victor E
   Greenberger, Benjamin A
   Shi, Zheng
   Gajjar, Shefali
   Shi, Wenyin
   Mourad, Waleed F
   Yan, Weisi
TI Post-mastectomy and post-breast conservation surgery pain syndrome: a review of 
SO Translational cancer research
LA English
DT Journal Article
DE Etiology; acupuncture; detection; early predictor; narrative medicine
AB Postmastectomy pain syndrome (PMPS) or breast conservation surgery (BCS) pain 
   syndrome could be long-term and lead to disability and impairment on body and 
   social function. The pain syndromes are not uncommon in breast cancer patients. 
   It can affect social, psychological, physical and behavioral aspects of a 
   patient. Surgery, radiation, chemotherapy and psychological factors can all 
   contribute to the development of pain syndromes. Axillary dissection is a strong 
   predictor for pain development. Pain medications, ganglion blocks are typically 
   given to the patient for management. Integrative medicine such as acupuncture and 
   psychological management methods are promising modalities in the management 
   arsenal. In this study, we summarized the up-to-date literature to elucidate the 
   etiology, risk factors and management strategies for PMPS.
C1 Department of Radiation Oncology, Sidney Kimmel Medical College & Cancer Center at Thomas Jefferson University, Philadelphia, PA, USA.
   Department of Radiation Oncology, Sidney Kimmel Medical College & Cancer Center at Thomas Jefferson University, Philadelphia, PA, USA.
   Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
   Department of Radiation Oncology, Sidney Kimmel Medical College & Cancer Center at Thomas Jefferson University, Philadelphia, PA, USA.
   Department of Radiation Oncology, Sidney Kimmel Medical College & Cancer Center at Thomas Jefferson University, Philadelphia, PA, USA.
   Department of Radiation Oncology, University of Kentucky, Lexington, KY, USA.
   Department of Radiation Oncology, Sidney Kimmel Medical College & Cancer Center at Thomas Jefferson University, Philadelphia, PA, USA.
NR 0
TC 0
SN 2219-680
EI 2218-676
J9 Transl Cancer Res
PD JAN 1
PY 2020
VL 9
IS Suppl 1
BP S77
EP S85
DI 10.21037/tcr.2019.06.46 
PG 1
UT PubMed:33828953
PM 33828953
DA 2020-01-01
ER

PT J
AU Hervik, J
   Mjåland, O
AF Hervik, Jill
   Mjåland, Odd
TI Quality of life of breast cancer patients medicated with anti-estrogens, 2 years 
SO International journal of women's health
LA English
DT Journal Article
DE anti-estrogen medication; breast cancer; quality of life
AB OBJECTIVE: The aim of this study was to examine the quality of life of breast 
   cancer patients medicated with estrogen antagonists, 2 years after having 
   acupuncture treatment for hot flashes. METHODS AND MATERIALS: Our sample was 
   taken from women who had recently participated in a randomized controlled trial 
   investigating the effects of acupuncture on hot flashes, a side effect of 
   estrogen-antagonist treatment. Forty-one women from the true acupuncture 
   treatment group and 41 women from the control group (sham acupuncture), who had 2 
   years previously received a course of 15 acupuncture treatments over a period of 
   10 weeks, were asked to answer an open question. The question, "Would you like to 
   share your thoughts and experiences related to your breast cancer diagnosis, 
   treatments or anything else?" was by being open, broad, and nonspecific, intended 
   to stimulate subjective information, which was not included in the original, or 
   future quantitative studies. Qualitative data were analyzed using systematic text 
   condensation. RESULTS: Most women were troubled by two or more side effects due 
   to anti-estrogen medication, negatively affecting their life quality. Symptoms 
   included hot flashes, sleep problems, muscle and joint pain, arm edema, fatigue, 
   weight gain, depression, and lack of sexual desire. Women previously treated with 
   sham acupuncture complained that hot flashes were still problematic, whilst those 
   previously treated with traditional Chinese acupuncture found them less of a 
   problem and generally had a more positive outlook on life. These results compare 
   favorably with the findings from our original study that measured quantitatively 
   health related quality of life. CONCLUSION: Side effects due to anti-estrogen 
   treatment seriously affect the quality of life of breast cancer operated 
   patients. Patients who had previously been treated with traditional Chinese 
   acupuncture complained less of hot flashes, and had a more positive outlook on 
   life, than women who had previously been treated with sham acupuncture.
C1 Pain Clinic, Vestfold Hospital, Tønsberg, Norway. jill.hervik@siv.no
NR 0
TC 0
SN 1179-141
EI 
J9 Int J Womens Health
PD DEC 15
PY 2010
VL 2
IS 
BP 319
EP 25
DI 10.2147/IJWH.S12809 
PG -294
UT PubMed:21151679
PM 21151679
DA 2010-12-15
ER

PT J
AU Duan, H
   Zhou, Y
   Ma, B
   Liu, R
   Yang, T
   Chu, H
   Huo, Z
   Qi, H
AF Duan, Hongyu
   Zhou, Yifan
   Ma, Baikai
   Liu, Rongjun
   Yang, Tingting
   Chu, Hongling
   Huo, Zejun
   Qi, Hong
TI Effect of Acupuncture Treatment on the Ocular Pain, Mental State and Ocular 
SO Clinical ophthalmology (Auckland, N.Z.)
LA English
DT Journal Article
DE acupuncture; depression; dry eye disease; inflammatory cytokines; ocular pain
AB BACKGROUND: Ocular pain is a prevalent symptom of dry eye disease (DED), which 
   often accompanies potential psychological issues. The study aimed to explore 
   whether acupuncture could improve ocular pain, mental state, and dry eye 
   parameters in patients with DED. METHODS: The non-randomized pilot study included 
   48 patients divided into two groups: the acupuncture group (n=27) and the 0.3% 
   sodium hyaluronate (SH) group (n=21). Participants in the acupuncture group 
   underwent treatments on six bilateral acupuncture points (BL1, BL2, ST1, LI 20, 
   SI1 and SI3) 3 times per week for 4 weeks. Patients in the SH group received 0.3% 
   SH 4 times per day for 4 weeks. Ocular pain was assessed using the numerical 
   rating scale (NRS), and mental state was evaluated through the self-rating 
   anxiety scale (SAS) and self-rating depression scale (SDS). Ocular surface 
   parameters, concentrations of inflammatory cytokines, and corneal nerve 
   morphological indicators were measured at baseline, the first week, and the 
   fourth week. Randomization procedures were not used in this study, and outcome 
   assessors and statistical analysts were blinded. RESULTS: Compared with baseline, 
   both NRS scores (from 5.91 ± 1.52 to 1.94 ± 1.57) and ocular surface discomfort 
   index (OSDI) scores (from 49.75 ± 14.92 to 29.64 ± 18.79) were decreased after 1 
   and 4 weeks of treatment in both groups (all p < 0.05). At 4 weeks, the 
   acupuncture group showed significant improvements, including increased tear 
   break-up time (TBUT) and corneal perception, decreased SAS and SDS scores, and 
   reduced concentrations of interleukin (IL)-1β, IL-6, and tumor necrosis factor 
   (TNF)-α concentration in tears (all p < 0.05). These changes were not observed in 
   the SH group (all p > 0.05). CONCLUSION: Acupuncture treatment could improve 
   ocular surface characteristics in patients with DED, and more importantly, it 
   alleviates their ocular pain and depressive state. The anti-inflammatory effect 
   of acupuncture may be involved in this process. Future research with larger, 
   randomized controlled trials (RCTs) is necessary to confirm these findings and 
   clarify the mechanisms involved.
C1 Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Beijing, People's Republic ofChina.
   Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.
   Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Beijing, People's Republic ofChina.
   Department of Ophthalmology, Peking University First Hospital, Beijing, People's Republic of China.
   Department of Ophthalmology, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, People's Republic of China.
   Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, People's Republic of China.
   Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing, People's Republic of China.
   Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Beijing, People's Republic ofChina.
NR 0
TC 0
SN 1177-548
EI 1177-546
J9 Clin Ophthalmol
PD OCT 8
PY 2024
VL 18
IS 
BP 2751
EP 2764
DI 10.2147/OPTH.S476573 
PG 13
UT PubMed:39376907
PM 39376907
DA 2024-10-08
ER

PT J
AU Sanaei, O
   Fernández-Esparrach, G
   De, La Serna-Higuera C
   Carrara, S
   Kumbhari, V
   El, Zein MH
   Ismail, A
   Ginès, A
   Sendino, O
   Montenegro, A
   Repici, A
   Rahal, D
   Brewer, Gutierrez OI
   Moran, R
   Yang, J
   Parsa, N
   Paiji, C
   Aghaie, Meybodi M
   Shin, EJ
   Lennon, AM
   Kalloo, AN
   Singh, VK
   Canto, MI
   Khashab, MA
AF Sanaei, Omid
   Fernández-Esparrach, Glòria
   De La Serna-Higuera, Carlos
   Carrara, Silvia
   Kumbhari, Vivek
   El Zein, Mohamad H
   Ismail, Amr
   Ginès, Angels
   Sendino, Oriol
   Montenegro, Andrea
   Repici, Alessandro
   Rahal, Daoud
   Brewer Gutierrez, Olaya I
   Moran, Robert
   Yang, Juliana
   Parsa, Nasim
   Paiji, Christopher
   Aghaie Meybodi, Mohamad
   Shin, Eun Ji
   Lennon, Anne Marie
   Kalloo, Anthony N
   Singh, Vikesh K
   Canto, Marcia Irene
   Khashab, Mouen A
TI EUS-guided 22-gauge fine needle biopsy versus single-incision with needle knife 
SO Endoscopy international open
LA English
DT Journal Article
AB Background and study aims  EUS-FNA has suboptimal accuracy in diagnosing 
   gastrointestinal subepithelial tumors (SETs). EUS-guided 22-gauge fine needle 
   biopsy (EUS-FNB) and single-incision with needle knife (SINK) were proposed to 
   increase accuracy of diagnosis. This study aimed to prospectively compare the 
   diagnostic accuracy and safety of EUS-FNB with SINK in patients with upper 
   gastrointestinal SETs. Patients and methods  All adult patients referred for EUS 
   evaluation of upper gastrointestinal SETs ≥ 15 mm in size were eligible for 
   inclusion. Patients were randomized to undergo EUS-FNB or SINK. Lesions were 
   sampled with a 22-gauge reverse beveled core needle in the EUS-FNB group and by a 
   conventional needle-knife sphincterotome and biopsy forceps in the SINK 
   group. Patients were blinded to the technique used. The primary outcome was 
   diagnostic accuracy. Secondary outcomes included adverse events, histological 
   yield and procedure duration. Study enrollment was terminated early due to poor 
   recruitment. Results  A total of 56 patients (31 male (55.37 %); mean age, 
   67.41 ± 12.70 years) were randomized to either EUS-FNB (n = 26) or SINK (n = 30). 
   Technical success was 96.15 % and 96.66 %, respectively. The majority of lesions 
   were gastrointestinal stromal tumors (51.78 %). No significant difference was 
   found between EUS-FNB and SINK in terms of diagnostic accuracy for a malignant or 
   benign disease (76 % vs. 89.28 %, respectively; P  = 0.278). The rate of adverse 
   events (none severe) was also comparable (7.69 % vs. 10 %, respectively; P =  
   1.0) including two abdominal pain episodes in the EUS-FNB group compared to two 
   delayed bleeding (one requiring hospitalization and radiologic embolization) and 
   1 abdominal pain in the SINK group. Conclusion  EUS-FNB and SINK are equally 
   effective techniques for upper gastrointestinal SETs sampling. SINK can be 
   associated with mild to moderate delayed bleeding.
C1 Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Endoscopy Unit, Gastroenterology Department, ICMDiM, Hospital Clinic, University of Barcelona, Catalonia, Spain.
   Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, 
   Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
   Gastroenterology Department, Hospital Universitario Rio Hortega, Valladolid, Spain.
   Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Endoscopy Unit, Gastroenterology Department, ICMDiM, Hospital Clinic, University of Barcelona, Catalonia, Spain.
   Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, 
   Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
   Endoscopy Unit, Gastroenterology Department, ICMDiM, Hospital Clinic, University of Barcelona, Catalonia, Spain.
   Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, 
   Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
   Endoscopy Unit, Gastroenterology Department, ICMDiM, Hospital Clinic, University of Barcelona, Catalonia, Spain.
   Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
   Department of Pathology, Humanitas Clinical and Research Center, Rozzano, Italy.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
   Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, United States.
NR 0
TC 0
SN 2196-973
EI 2364-372
J9 Endosc Int Open
PD MAR 3
PY 2020
VL 8
IS 3
BP E266
EP E273
DI 10.1055/a-1075-1900 
PG 1
UT PubMed:32118100
PM 32118100
DA 2020-03-03
ER

PT J
AU Saraswati, W
   Wardani, R
   Suhatno
   Hartono, P
   Imandiri, A
AF Saraswati, Wita
   Wardani, Ratih
   Suhatno
   Hartono, Pudjo
   Imandiri, Ario
TI WITHDRAWN: The Effect of Electroacupuncture Therapy on Pain, Plasma β-Endorphin, 
SO Journal of acupuncture and meridian studies
LA English
DT Journal Article
AB This article has been withdrawn at the request of the editor. The Publisher 
   apologizes for any inconvenience this may cause. The full Elsevier Policy on 
   Article Withdrawal can be found at 
   https://www.elsevier.com/about/our-business/policies/article-withdrawal.
C1 Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
   Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
   Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
   Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
   Department of Traditional Healer, Faculty of Vocations, Universitas Airlangga, Surabaya, Indonesia.
NR 0
TC 0
SN 2093-815
EI 
J9 J Acupunct Meridian Stud
PD JAN 8
PY 2021
VL 0
IS 
BP 
EP 
DI 10.1016/j.jams.2020.12.005 
PG 0
UT PubMed:33412296
PM 33412296
DA 2021-01-08
ER

PT J
AU Chen, CT
   Lin, JG
   Huang, CP
   Lin, YW
AF Chen, Chao-Tsung
   Lin, Jaung-Geng
   Huang, Chun-Ping
   Lin, Yi-Wen
TI Electroacupuncture attenuates chronic fibromyalgia pain through the 
SO Iranian journal of basic medical sciences
LA English
DT Journal Article
DE 3-kinase; Dorsal root ganglion; Electroacupuncture; Fibromyalgia; Phosphatidylinositol; Somatosensory cortex; Thalamus
AB OBJECTIVES: Fibromyalgia (FM) is a central nervous system disorder characterized 
   by widespread mechanical hyperalgesia due to unknown mechanisms. Several 
   inflammatory mediators, such as interleukin-1 (IL-1), IL-6, IL-8, and tumor 
   necrosis factor, are increased in the serum of FM patients. Although medications 
   including pregabalin, duloxetine, and milnacipran are used to treat FM, the 
   results are unsatisfying. In the present study we assessed whether 
   electroacupuncture (EA) can reduce chronic FM pain and then proposed an 
   underlying mechanism for this effect. MATERIALS AND METHODS: Chronic FM pain was 
   induced in mice by dual acid saline injection lasting up to 4 weeks. RESULTS: 
   Chronic FM pain was treated by EA manipulation, but not in the sham operated 
   group. Phosphorylated phosphatidylinositol 3-kinase (pPI3K), protein kinase B, 
   mechanistic target of rapamycin, and nuclear factor kappa-light-chain-enhancer of 
   activated B cells were unaltered in the mouse dorsal root ganglion (DRG) and 
   spinal cord (SC) after inducing FM and administering EA treatment. The 
   pPI3K-associated nociceptive signaling pathway was increased in the thalamus of 
   FM mice, but reversed by EA. Similar results were observed in the mouse 
   somatosensory cortex. CONCLUSION: These data suggest that EA has a significant 
   effect on a signaling pathway in brain areas of FM mice. These findings suggest 
   the value of EA for clinical practice.
C1 Center for General Education, Chung Yuan Christian University, Taoyuan 32023, Taiwan.
   College of Chinese Medicine, School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
   College of Chinese Medicine, Graduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan.
   College of Chinese Medicine, Graduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan.
NR 0
TC 0
SN 2008-387
EI 2008-386
J9 Iran J Basic Med Sci
PD DEC 7
PY 2019
VL 22
IS 9
BP 1085
EP 1090
DI 10.22038/ijbms.2019.35887.8547 
PG 5
UT PubMed:31807253
PM 31807253
DA 2019-12-07
ER

PT J
AU Smith, CL
   Reddy, B
   Wolf, CM
   Schnyer, RN
   St, John K
   Conboy, L
   Stone, J
   Lao, L
AF Smith, Clasina Leslie
   Reddy, Bill
   Wolf, Charis M
   Schnyer, Rosa N
   St John, Korina
   Conboy, Lisa
   Stone, Jen
   Lao, Lixing
TI The State of 21st Century Acupuncture in the United States.
SO Journal of pain research
LA English
DT Journal Article
DE acupuncture; herbal medicine; integrative health; integrative medicine; medical policy; traditional Chinese medicine
AB The term "acupuncture" commonly refers to a non-pharmacologic therapy that is 
   increasingly employed by diverse segments of the population for a wide variety of 
   complaints including pain, insomnia, anxiety, depression, frozen shoulder, and 
   other issues. The term is also used as a short-hand for the wider medical system 
   from which the placement of needles into the skin for therapeutic benefit and 
   related techniques evolved. Thus "acupuncture" refers both to the therapeutic 
   technique and the therapeutic system of Acupuncture and Herbal Medicine (AHM). 
   The other modalities included within AHM include a wide variety of physical and 
   mechanical manipulations, herbal medicines, dietary recommendations, and 
   lifestyle modifications. Clinically, acupuncture is increasingly offered in a 
   variety of conventional medical settings such as hospitals, medical school 
   clinics, veterans' healthcare centers, oncology facilities, and rehabilitation 
   centers, and its safety profile is excellent overall. Barriers to further 
   incorporation of acupuncture into biomedical sites include insurance coverage of 
   acupuncture, education of conventional medical practitioners and other 
   stakeholders about the utility, efficacy, and evidence base of acupuncture. 
   Acupuncturists in the United States are skilled practitioners who are highly 
   educated in the complex therapeutic system from which acupuncture arose and in 
   the technical aspects of its utility as a treatment modality. The training, 
   certification, licensure, and regulation of acupuncturists is similar to that of 
   conventional providers such has physician's assistants, advanced practice nurses, 
   and medical and osteopathic doctors. While clinical use and acceptance of 
   acupuncture continues to grow, there is to date no definitive composite document 
   explaining the utility of acupuncture in various healthcare settings, the current 
   understanding of how acupuncture works, and the training, professional 
   regulation, and certification of acupuncture practitioners. This article will 
   address these topics and strive to create a reference for practitioners, 
   administrators, legislators, insurance providers, patients and their families, 
   and other stakeholders.
C1 Chicago Healing Center, Chicago, IL, USA.
   School of Medicine, Southern Illinois University, Springfield, IL, USA.
   Vital Point Acupuncture, Annandale, VA, USA.
   Seattle Institute of East Asian Medicine, Seattle, WA, USA.
   Middle Way Acupuncture Institute, Seattle, WA, USA.
   School of Nursing, University of Texas, Austin, TX, USA.
   Oregon College of Oriental Medicine, Portland, OR, USA.
   Modern Medicine Woman, LLC, Palmer, AK, USA.
   Seattle Institute of East Asian Medicine, Seattle, WA, USA.
   Oregon College of Oriental Medicine, Portland, OR, USA.
   Beth Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
   California Institute of Integral Studies, San Francisco, CA, USA.
   Pacific College of Oriental Medicine, San Diego, CA, USA.
   YoSan University, Los Angeles, CA, USA.
   Five Branches University, Santa Cruz, CA, USA.
   American Academy of Health and Wellness, Roseville, MN, USA.
   CTSI, Indiana University School of Medicine, Indianapolis, IN, USA.
   Virginia University of Integrative Medicine, Vienna, VA, USA.
   School of Medicine, University of Maryland, Baltimore, MD, USA.
   School of Chinese Medicine, University of Hong Kong, Pokfulam, Hong Kong.
NR 0
TC 0
SN 1178-709
EI 1178-709
J9 J Pain Res
PD OCT 15
PY 2024
VL 17
IS 
BP 3329
EP 3354
DI 10.2147/JPR.S469491 
PG 25
UT PubMed:39403098
PM 39403098
DA 2024-10-15
ER

PT J
AU Wang, Y
   Zhang, J
   Jin, Y
   Zhang, Q
AF Wang, Yunxia
   Zhang, Jiayuan
   Jin, Yuxia
   Zhang, Qi
TI Auricular Acupressure Therapy for Patients with Cancer with Sleep Disturbance: A 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Review
AB AIM: We aim to provide available synthesized evidence of the efficacy and safety 
   of auricular acupressure for cancer patients with sleep disturbance. METHODS: 
   Randomized controlled clinical trials (RCTs) were identified from PubMed, EMBASE, 
   Web of Science, The Cochrane Library, PsycINFO, Chinese Biomedical Database, 
   China National Knowledge Infrastructure, Chongqing VIP, and Wanfang Data, and the 
   search date ranged from the inception of the databases to May 2021. Literature 
   screening and data extraction were independently performed by three researchers. 
   The Cochrane collaboration's tool for assessing the risk of bias was applied to 
   evaluate the risk of bias of the RCTs included. The extracted data were analyzed 
   using Rev-Man 5.4.1 software. RESULTS: Nine trials involving 688 participants met 
   the inclusion criteria and were included in the qualitative analysis; 6 trials 
   involving 485 participants were included in the meta-analysis. Synthesized 
   results showed that auricular acupressure had a significant effect on reducing 
   the total Pittsburgh Sleep Quality Index (PSQI) score (MD = -3.88, 95% CI (-5.24, 
   -2.53), P < 0.00001), and the scores of five PSQI components, sleep latency 
   (MD = -0.53, 95% CI (-0.73, -0.32), P < 0.00001), subjective sleep quality 
   (MD = -0.79, 95% CI (-1.05, -0.53), P < 0.00001), sleep duration (MD = -0.50, 95% 
   CI (-0.69, -0.31), P < 0.0001), daytime dysfunction (MD = -0.53, 95% CI (-0.77, 
   -0.29), P < 0.0001), and sleep disturbances (MD = -0.54, 95% CI (-0.60, -0.49), P 
   < 0.00001), were also obviously decreased after the intervention of auricular 
   acupressure. Shenmen and heart were the most commonly selected auricular 
   acupoints, the main intervention durations ranged from 10 to 42 days, and the 
   pressing times of auricular acupoints were 1-6 times a day, 1-5 min each time. 
   One trial reported slight and transient pain caused by auricular acupressure, 
   while the remaining 8 trials did not report obvious side effects. CONCLUSION: 
   Auricular acupressure can significantly improve the sleep quality of cancer 
   patients with sleep disturbance, with no obvious side effects. Rigorously 
   designed clinical trials are necessary for the further support of the clinical 
   application.
C1 Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
   Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD OCT 26
PY 2021
VL 2021
IS 
BP 3996101
EP 3996101
DI 10.1155/2021/3996101 
PG 0
UT PubMed:34691214
PM 34691214
DA 2021-10-26
ER

PT J
AU Tian, H
   Luo, Q
   Huang, L
   Chen, G
   Sun, M
   Liang, F
AF Tian, Hao
   Luo, Qin
   Huang, Liuyang
   Chen, Guang
   Sun, Mingsheng
   Liang, Fanrong
TI Exploration of the quantitative-effectiveness association between acupuncture 
SO Frontiers in oncology
LA English
DT Review
DE acupuncture; chemotherapy-induced peripheral neuropathy; dose-response; meta-analysis; pain management
AB BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the 
   commonly reported symptoms impacting cancer survivors. This study evaluated and 
   compared the effectiveness of acupuncture treatments for CIPN. METHODS: We 
   searched six databases from their inception to August 2024 to identify eligible 
   randomized controlled trials (RCTs). Primary outcome were pain scores. Secondary 
   outcomes were quality of life including FACT/GOG-Ntx and EORTC QLQ-C30. The 
   robust error meta-regression (REMR) method was used to evaluate the dose-response 
   relationship across treatment parameters, including number of sessions, 
   frequency, and duration. RESULTS: In total, 11 RCTs featuring 740 participants 
   were included. The meta-analysis demonstrated that the primary analysis achieved 
   a significant reduction in pain scores, with a standardized mean difference of 
   [SMD= -1.23, 95% CI = (-2.22, -0.24); P < 0.01; I² = 95%], improvement quality of 
   life including FACT/GOG-Ntx [SMD = 0.95, 95% CI = (0.02, 1.88); P < 0.01; I² = 
   93%] and EORTC QLQ-C30 [SMD = 0.36, 95% CI = (0.03, 0.68); P = 0.14; I² = 46%]. 
   The nonlinear dose-response analysis suggests that pain improvement achieves the 
   MCID at 16 treatment sessions, over 8 weeks, with a frequency of twice per week. 
   Furthermore, analysis of the treatment duration chart shows that acupuncture 
   maintains therapeutic effects during the follow-up period. Sensitivity analysis 
   confirmed the robustness of these findings. CONCLUSION: Acupuncture demonstrates 
   significant potential in managing CIPN, particularly through individualized 
   treatment regimens. The identified time-dose-response relationship suggests that 
   tailoring acupuncture frequency and duration can to optimize pain relief in CIPN 
   patients. Future high-quality studies and large-scale multicenter clinical trials 
   are needed to validate these findings.
C1 College of Acupuncture and Tuina/The 3rd Teaching Hospital/College of Basic Medicine/College of International Education, Chengdu University of TraditionalChinese Medicine/Clinical Research Center for Acupuncture and Moxibustion inSichuan Province, Chengdu, Sichuan, China.
   Department of Rheumatology and Orthopedics, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, China.
   College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, China.
   Hubei Provincial Collaborative Innovation Center of Preventive Treatment by 
   Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China.
   College of Acupuncture and Tuina/The 3rd Teaching Hospital/College of Basic Medicine/College of International Education, Chengdu University of TraditionalChinese Medicine/Clinical Research Center for Acupuncture and Moxibustion inSichuan Province, Chengdu, Sichuan, China.
   College of Acupuncture and Tuina/The 3rd Teaching Hospital/College of Basic Medicine/College of International Education, Chengdu University of TraditionalChinese Medicine/Clinical Research Center for Acupuncture and Moxibustion inSichuan Province, Chengdu, Sichuan, China.
   College of Acupuncture and Tuina/The 3rd Teaching Hospital/College of Basic Medicine/College of International Education, Chengdu University of TraditionalChinese Medicine/Clinical Research Center for Acupuncture and Moxibustion inSichuan Province, Chengdu, Sichuan, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD MAR 4
PY 2025
VL 14
IS 
BP 1527331
EP 1527331
DI 10.3389/fonc.2024.1527331 
PG 0
UT PubMed:40034252
PM 40034252
DA 2025-03-04
ER

PT J
AU Tang, HY
   Chen, XQ
   Wang, H
   Chu, HR
   Zhu, CF
   Huang, S
   Zhang, MT
   Shen, GM
AF Tang, He-Yong
   Chen, Xi-Qiuyu
   Wang, Hao
   Chu, Hao-Ran
   Zhu, Cai-Feng
   Huang, Shun
   Zhang, Meng-Ting
   Shen, Guo-Ming
TI Acupuncture relieves the visceral pain of diarrhea-predominant irritable bowel 
SO American journal of translational research
LA English
DT Journal Article
DE IBS-D rat; P2X4; acupuncture; visceral pain
AB OBJECTIVES: We researched the effect and mechanism of acupuncture treatment for 
   visceral pain in rats with diarrhea-predominant irritable bowel syndrome (IBS-D). 
   METHODS: We set up a rat model of IBS-D with chemical and chronic- and 
   acute-pressure stimulations. Then, the IBS-D rats were treated with acupuncture 
   or 5-BDBD, and the therapeutic efficacy of acupuncture in IBS-D rats was assessed 
   by means of the Bristol scale, diarrhea index, abdominal withdrawal reflex (AWR) 
   score, mast cell count and histologic staining. RESULTS: Acupuncture 
   significantly decreased clinical symptoms in IBS-D rats after a 14 day-treatment. 
   Furthermore, significant down-regulation of P2X4, OX42, BDNF (brain-derived 
   neurotrophic factor) and IRF-5 (interferon regulatory factor 5) expressions were 
   observed in the IBS-D rats, along with the decreased inflammatory factors 
   [interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and interleukin 
   6 (IL-6)], chemokines [monocyte chemoattractant protein-1 (MCP-1), regulated on 
   activation, normal T cell expressed and secreted (RANTES), and C-X-C motif 
   chemokine ligand 1 (CXCL1)], and neurotransmitters [substance P (SP), 
   5-hydroxytryptamine (5-HT), and calcitonin gene-related peptide (CGRP)]. 5-BDBD 
   treatment had a similar effect on IBS-D rats. CONCLUSIONS: Acupuncture can 
   effectively alleviate abdominal pain by decreasing visceral hypersensitivity and 
   controlling the expression of P2X4 and spinal microglial inflammation in IBS 
   rats.
C1 School of Integrated Traditional Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine Hefei 230012, Anhui, China.
   School of Integrated Traditional Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine Hefei 230012, Anhui, China.
   School of Integrated Traditional Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine Hefei 230012, Anhui, China.
   The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine Hefei 230012, Anhui, China.
   The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine Hefei 230012, Anhui, China.
   School of Integrated Traditional Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine Hefei 230012, Anhui, China.
   School of Integrated Traditional Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine Hefei 230012, Anhui, China.
   School of Integrated Traditional Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine Hefei 230012, Anhui, China.
NR 0
TC 0
SN 1943-814
EI 1943-814
J9 Am J Transl Res
PD SEP 16
PY 2022
VL 14
IS 8
BP 5563
EP 5573
DI 
PG 10
UT PubMed:36105029
PM 36105029
DA 2022-09-16
ER

PT J
AU Smeester, BA
   Al-Gizawiy, M
   Beitz, AJ
AF Smeester, Branden A
   Al-Gizawiy, Mona
   Beitz, Alvin J
TI Effects of different electroacupuncture scheduling regimens on murine bone 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB Previous studies have shown that electroacupuncture (EA) is able to reduce 
   hyperalgesia in rodent models of persistent pain, but very little is known about 
   the analgesic effects and potential sex differences of different EA treatment 
   regimens. In the present study, we examined the effects of five different EA 
   treatments on tumor-induced hyperalgesia in male and female mice. EA applied to 
   the ST-36 acupoint either twice weekly (EA-2X/3) beginning on postimplantation 
   day (PID) 3 or prophylactically three times prior to implantation produced the 
   most robust and longest lasting antinociceptive effects. EA treatment given once 
   per week beginning at PID 7 only produced an antinociceptive effect in female 
   animals. The analgesic effect of EA-2X/3 began earlier in males, but lasted 
   longer in females indicating sex differences in EA. We further demonstrate that 
   EA-2X/3 elicits a marked decrease in tumor-associated inflammation as evidenced 
   by a significant reduction in tumor-associated neutrophils at PID 7. Moreover, 
   EA-2X/3 produced a significant reduction in tumor-associated PGE(2) as measured 
   in microperfusate samples. Collectively, these data provide evidence that EA-2X/3 
   treatment reduces tumor-induced hyperalgesia, which is associated with a decrease 
   in tumor-associated inflammation and PGE(2) concentration at the tumor site 
   suggesting possible mechanisms by which EA reduces tumor nociception.
C1 Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD JAN 16
PY 2013
VL 2012
IS 
BP 671386
EP 671386
DI 10.1155/2012/671386 
PG 0
UT PubMed:23320035
PM 23320035
DA 2013-01-16
ER

PT J
AU Jeong, YJ
   Kwak, MA
   Seo, JC
   Park, SH
   Bong, JG
   Shin, IH
   Park, SH
AF Jeong, Young Ju
   Kwak, Min Ah
   Seo, Jung Chul
   Park, Seong Hoon
   Bong, Jin Gu
   Shin, Im Hee
   Park, Sung Hwan
TI Acupuncture for the Treatment of Taxane-Induced Peripheral Neuropathy in Breast 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB OBJECTIVES: Some chemotherapy drugs can damage the nerves and cause peripheral 
   neuropathy which is accompanied by severe neuropathic pain or gait impairment. 
   The purpose of this study was to assess the feasibility and the safety of 
   acupuncture for the treatment of peripheral neuropathy following chemotherapy in 
   Korean breast cancer patients. DESIGN: This study was a prospective single-arm 
   observational study using before and after measurements in breast cancer patients 
   presenting with taxane-induced peripheral neuropathy. SETTINGS/LOCATION: This 
   study was performed at East-West Medical Center at Daegu Catholic University 
   Hospital, Daegu, South Korea. INTERVENTIONS: Acupuncture was administered 3 times 
   a week for 4 consecutive weeks, for 25 ± 5 minutes at each session. OUTCOME 
   MEASURES: The primary outcome measure was severity of CIPN using the Neuropathic 
   Pain Symptom Inventory (NPSI) assessed by a self-administered questionnaire and 
   Nerve Conduction Study (NCS) of extremities. The secondary outcome measure was 
   quality of life (QoL) assessed by a self-administered questionnaire using the 
   36-Item Short From Health Survey (SF-36). RESULTS: Acupuncture significantly 
   reduced the severity of CIPN assessed by NPSI score. Four weeks after the last 
   treatment, the symptoms were not aggravated. According to NCS, 42.9% of 
   participants showed improvement of sensory neuropathy. At the end of the 
   treatment, SF-36 scores were significantly increased for variables including 
   physical functioning, role limitations due to physical health problems, social 
   functioning, and general health perceptions compared to those of baseline 
   measurement. CONCLUSIONS: Acupuncture improved symptoms of CIPN and QoL in Korean 
   women suffering from peripheral neuropathy after chemotherapy using taxane for 
   breast cancer. The effects of acupuncture lasted for at least 1 month after the 
   treatment.
C1 Department of Surgery, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
   Department of Oriental Internal Medicine, College of Oriental Medicine, Daegu Haany University, Daegu, Republic of Korea.
   Comprehensive and Integrative Medicine Institute, Daegu, Republic of Korea.
   Comprehensive and Integrative Medicine Institute, Daegu, Republic of Korea.
   Department of Surgery, Raphael Hospital, Daegu, Republic of Korea.
   Department of Medical Statistics, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
   Department of Surgery, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD NOV 14
PY 2018
VL 2018
IS 
BP 5367014
EP 5367014
DI 10.1155/2018/5367014 
PG 0
UT PubMed:30420895
PM 30420895
DA 2018-11-14
ER

PT J
AU Zhou, J
   Fang, L
   Wu, WY
   He, F
   Zhang, XL
   Zhou, X
   Xiong, ZJ
AF Zhou, J
   Fang, L
   Wu, W Y
   He, F
   Zhang, X L
   Zhou, X
   Xiong, Z J
TI The effect of acupuncture on chemotherapy-associated gastrointestinal symptoms in 
SO Current oncology (Toronto, Ont.)
LA English
DT Journal Article
DE Acupuncture; chemotherapy; gastric cancer; gastrointestinal symptoms; quality of life
AB BACKGROUND: Gastrointestinal (gi) symptoms are the most notable side effects of 
   chemotherapeutic drugs; such symptoms are currently treated with drugs. In the 
   present study, we investigated the effect of acupuncture on gi symptoms induced 
   by chemotherapy in patients with advanced gastric cancer. METHODS: A cohort of 56 
   patients was randomly divided into an experimental group and a control group. All 
   patients received combination chemotherapy with oxaliplatin-paclitaxel. Patients 
   in the experimental group received 30 minutes of acupuncture therapy daily for 2 
   weeks. The frequency and duration of nausea, vomiting, abdominal pain, and 
   diarrhea, the average days and costs of hospitalization, and quality-of-life 
   scores were compared between the groups. RESULTS: Nausea was sustained for 32 ± 5 
   minutes and 11 ± 3 minutes daily in the control and experimental groups 
   respectively (p < 0.05). On average, vomiting occurred 2 ± 1 times daily in the 
   experimental group and 4 ± 1 times daily in the control group (p < 0.05). 
   Abdominal pain persisted for 7 ± 2 minutes and 16 ± 5 minutes daily in the 
   experimental and control groups respectively (p < 0.05). On average, diarrhea 
   occurred 1 ± 1 times daily in the experimental group and 3 ± 1 times daily in the 
   control group (p < 0.05). The average quality-of-life score was higher in the 
   experimental group than in the control group (p < 0.05). No adverse events were 
   observed for the patients receiving acupuncture. CONCLUSIONS: Acupuncture, a safe 
   technique, could significantly reduce gi symptoms induced by chemotherapy and 
   enhance quality of life in patients with advanced gastric cancer.
C1 Department of Chemotherapy, Sichuan Cancer Hospital, and.
   Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R.C.
   Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R.C.
   Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R.C.
   Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R.C.
   Department of Chemotherapy, Sichuan Cancer Hospital, and.
   Department of Chemotherapy, Sichuan Cancer Hospital, and.
NR 0
TC 0
SN 1718-772
EI 1198-005
J9 Curr Oncol
PD MAR 9
PY 2017
VL 24
IS 1
BP e1
EP e5
DI 10.3747/co.24.3296 
PG 1
UT PubMed:28270726
PM 28270726
DA 2017-03-09
ER

PT J
AU Chu, EC
   Lee, WT
AF Chu, Eric Chun-Pu
   Lee, Wai Ting
TI Prostate Cancer Presenting as Hip Pain at the Chiropractic Office: A Case Report 
SO Cureus
LA English
DT Journal Article
DE chiropractic; hip cancer; hip metastasis; hip pain; prostate cancer
AB Prostate cancer is one of the most common cancers found in males, and it tends to 
   metastasize to bony parts such as the hip, spine, and pelvis, resulting in pain 
   and/or radicular pain, which can present similarly to musculoskeletal complaints. 
   The lack of routine screening and musculoskeletal symptoms present challenges in 
   the diagnosis of prostate cancer. We report the case of a 62-year-old male with 
   no history of cancer and no previous prostate cancer screening who visited a 
   chiropractor for the care of worsening left hip pain after a marathon. The 
   patient visited other healthcare providers and was suggested to have degenerative 
   conditions; he received nonsteroidal anti-inflammatory medication, physiotherapy, 
   and acupuncture. Given the patient's limited improvement by other providers and 
   neurological symptoms, the chiropractor requested lumbar spine radiography, which 
   revealed suspected bone metastasis, and ordered a hip MRI accordingly. MRI 
   findings suggested prostate cancer, and the chiropractor referred the patient to 
   an oncologist, who performed additional imaging and testing to make a presumptive 
   prostate cancer diagnosis. A literature search found nine cases of undiagnosed 
   prostate cancer presenting to a chiropractor for care. All patients included in 
   this case were older males with no previous prostate screening or bone 
   metastasis. The study is focused on the need for a comprehensive evaluation of 
   patients with hip pain during a chiropractic visit due to the chances of prostate 
   cancer. There are higher chances of ignoring cancer symptoms during a hip 
   examination. Comprehensive evaluation and advanced imaging could help 
   chiropractors detect patients with prostate cancer.
C1 Department of Chiropractic and Physiotherapy, New York Chiropractic and Physiotherapy Centre, Hong Kong, HKG.
   Department of Chiropractic and Physiotherapy, New York Chiropractic and Physiotherapy Centre, Hong Kong, HKG.
NR 0
TC 0
SN 2168-818
EI 2168-818
J9 Cureus
PD FEB 25
PY 2023
VL 15
IS 1
BP e34049
EP e34049
DI 10.7759/cureus.34049 
PG 1
UT PubMed:36824534
PM 36824534
DA 2023-02-25
ER

PT J
AU Lu, DP
   Lu, GP
AF Lu, Dominic P
   Lu, Gabriel P
TI An Historical Review and Perspective on the Impact of Acupuncture on U.S. 
SO Medical acupuncture
LA English
DT Review
DE Acupuncture; Health Care; Impact; Perspective
AB BACKGROUND: It took almost 300 years for Europe and 400 years for the United 
   States to finally appreciate the therapeutic value of acupuncture. Findings from 
   basic medical research that acupuncture stimulation causes release of endorphins, 
   serotonin, enkephalins, and γ-amino-butyric acid (GABA; a major inhibitory 
   neurotransmitter of the brain), norepinephrine, and dopamine helped to explain 
   the acupuncture effect on a biomedical and pharmacological basis that was 
   acceptable to the Western medical establishment. CONTEXT: In the United States, 
   there is significantly increased familiarity with acupuncture and U.S. patients 
   have sought acupuncture treatment to relieve stress-related syndromes, to enhance 
   the immune system, to reduce insomnia, to improve athletic performance, and to 
   address Alzheimer's disease, as well as for cardiac and poststroke therapy. This 
   article briefly reviews the history of acupuncture in the United States and 
   discusses the potential of this modality in the the future. DISCUSSION: 
   Acupuncture can be combined with conventional Western medicine for pain 
   management in patient with cancer to reduce dosages of narcotic medications, 
   side-effects, adverse reactions, and the possibility of narcotic addiction. 
   Because of acupuncture's increased popularity, acupuncture training schools have 
   been set up in the United States, and some insurance companies cover acupuncture 
   therapy. CONCLUSIONS: By studying both Eastern and Western medicine and using 
   them in a complementary fashion, we open ourselves to many discoveries for the 
   benefit of humanity.
C1 Department of Oral Medicine, University Pennsylvania , Philadelphia, PA.
   Department of Clinical Anesthesiology, Albert Einstein College of Medicine , Bronx, NY.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD APR 25
PY 2014
VL 25
IS 5
BP 311
EP 316
DI 10.1089/acu.2012.0921 
PG 5
UT PubMed:24761180
PM 24761180
DA 2014-04-25
ER

PT J
AU Liu, L
   Yin, P
   Dong, Y
   Fan, Q
   Huai, Y
   Zhang, S
   Lv, S
   Wang, X
   Chen, Y
AF Liu, Lumin
   Yin, Ping
   Dong, Yiyue
   Fan, Qian
   Huai, Yisheng
   Zhang, Shijie
   Lv, Shunyi
   Wang, Xueyang
   Chen, Yuelai
TI Neurological mechanism and efficacy of acupuncture for breast cancer-related 
SO Frontiers in neurology
LA English
DT Journal Article
DE acupuncture; breast cancer; fMRI; insomnia; protocol; randomized controlled trial
AB BACKGROUND: Breast cancer survivors (BCSs) are at a higher risk of developing 
   insomnia. The negative effects of cancer-related insomnia (CRI) include 
   depression, anxiety, fatigue, aggressive pain, impaired immune functioning, 
   decreased quality of life, and even increased cancer mortality. Although 
   preliminary progress has been made in the treatment of CRI with acupuncture, the 
   evidence is insufficient and the neurological mechanism underlying the effect of 
   acupuncture is still unclear. METHODS: The study employs a single-blinded, 
   randomized, controlled trial design. A total of 80 participants will be randomly 
   allocated in a 1:1 ratio to either the treatment group (n = 40) or the control 
   group (n = 40). The former will receive acupuncture treatment, while the latter 
   will receive sham acupuncture treatment. Both groups will receive 12 sessions 
   over a 4-week period, three times per week (every other day), and each session 
   will last for 30 min. Follow-up assessments will be conducted in week 8. The 
   primary outcome will be the treatment response rate. Secondary outcomes include 
   the change in Insomnia Severity Index (ISI), the treatment remission rate, 
   actigraphy sleep assessment, Generalized Anxiety Disorder Scale (GAD-7), Patient 
   Health Questionnaire-9 (PHQ-9), Quality of Life Core Scale (QLQ-C30), the weekly 
   usage of remedial drugs, and functional magnetic resonance imaging (fMRI) 
   analysis. Data for the outcomes will be collected at week 0 (the baseline), week 
   1 (the intervention period), week 4 (the post-treatment period), and week 8 (the 
   follow-up period). DISCUSSION: The objective of this study is to assess the 
   efficacy of acupuncture for patients with CRI in comparison with sham 
   acupuncture. Additionally, the research aims to explore the neuropathological 
   mechanisms of CRI and provide the first evidence on the characteristics of 
   acupuncture treatment using fMRI. We expect that the results of this study will 
   provide valuable scientific evidence of acupuncture treatment for CRI.Clinical 
   trial registration: Chinese Clinical Trial Registry, identifier ChiCTR2300070349: 
   https://www.chictr.org.cn/showproj.html?proj=188677.
C1 LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
   LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
NR 0
TC 0
SN 1664-229
EI 1664-229
J9 Front Neurol
PD JAN 8
PY 2024
VL 14
IS 
BP 1278564
EP 1278564
DI 10.3389/fneur.2023.1278564 
PG 0
UT PubMed:38187141
PM 38187141
DA 2024-01-08
ER

PT J
AU Schlaeger, J
   Cai, HY
   Steffen, AD
   Angulo, V
   Shroff, AR
   Briller, JE
   Hoppensteadt, D
   Uwizeye, G
   Pauls, HA
   Takayama, M
   Yajima, H
   Takakura, N
   DeVon, HA
AF Schlaeger, Judith
   Cai, Hui Yan
   Steffen, Alana D
   Angulo, Veronica
   Shroff, Adhir R
   Briller, Joan E
   Hoppensteadt, Debra
   Uwizeye, Glorieuse
   Pauls, Heather A
   Takayama, Miho
   Yajima, Hiroyoshi
   Takakura, Nobuari
   DeVon, Holli A
TI Acupuncture to Improve Symptoms for Stable Angina: Protocol for a Randomized 
SO JMIR research protocols
LA English
DT Journal Article
DE acupuncture; complementary medicine; ischemic heart disease; stable angina
AB BACKGROUND: Acupuncture has demonstrated physiologic analgesic effects in Chinese 
   patients with stable angina. One proposed mechanism of action for these analgesic 
   effects is the downregulation of M1 macrophages, interleukin 1 beta, 
   interleukin-6, interleukin-18, and tumor necrosis factor alpha. OBJECTIVE: This 
   study aims to test a 10-session, 5-week acupuncture treatment protocol as a 
   complementary therapy for symptoms of stable angina for American patients, who 
   vary from Chinese patients in health care systems and other salient variables. 
   METHODS: We are conducting a randomized controlled trial (RCT) of 69 adults (35 
   assigned to initial acupuncture and 34 to an attention control condition) with a 
   medically confirmed diagnosis of stable angina, whose pain and associated 
   symptoms have not been controlled to their satisfaction with guideline-directed 
   medical management. Participants in the experimental group will receive a 
   standardized traditional Chinese medicine point prescription. The attention 
   control group will view non-pain-related health education videos over 5 weeks 
   equal to the 10 hours of treatment for the acupuncture group. Participants will 
   complete the McGill Pain Questionnaire and the Seattle Angina Questionnaire-7, as 
   well as have inflammatory cytokines measured at baseline and study completion. 
   The primary outcomes are anginal pain and quality of life. RESULTS: This study 
   has been funded over 2 years by the National Institutes of Health, National 
   Institute for Nursing Research. We are currently recruiting and expect to have 
   initial results by December 2020. CONCLUSIONS: We will generate data on 
   feasibility, acceptability, effect sizes, and protocol revisions for a future 
   fully powered RCT of the protocol. Findings will help determine if patients with 
   persistent ischemic symptoms experience a proinflammatory state and hyperalgesia 
   caused by multiple neural and immune processes not always relieved with 
   medication. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): 
   DERR1-10.2196/14705.
C1 Department of Women, Children and Family Health Science, College of Nursing, University of Illinois at Chicago, Chicago, IL, United States.
   Department of Acupuncture and Oriental Medicine, National University of Health Sciences, Lagrange, IL, United States.
   Department of Health Systems Science, College of Nursing, University of Illinois at Chicago, Chicago, IL, United States.
   Department of Women, Children and Family Health Science, College of Nursing, University of Illinois at Chicago, Chicago, IL, United States.
   Department of Cardiology, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States.
   Department of Cardiology, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States.
   Department of Pathology and Pharmacology, Loyola University Medical Center, Maywood, IL, United States.
   Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago, Chicago, IL, United States.
   Office of Research Facilitation, College of Nursing, University of Illinois at Chicago, Chicago, IL, United States.
   Department of Acupuncture and Moxibustion, Tokyo Ariake University of Medical and Health Sciences, Tokyo, Japan.
   Department of Acupuncture and Moxibustion, Tokyo Ariake University of Medical and Health Sciences, Tokyo, Japan.
   Department of Acupuncture and Moxibustion, Tokyo Ariake University of Medical and Health Sciences, Tokyo, Japan.
   Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago, Chicago, IL, United States.
NR 0
TC 0
SN 1929-074
EI 1929-074
J9 JMIR Res Protoc
PD JUL 31
PY 2019
VL 8
IS 7
BP e14705
EP e14705
DI 10.2196/14705 
PG 1
UT PubMed:31359872
PM 31359872
DA 2019-07-31
ER

PT J
AU Gómez-Neva, ME
   Pulido-Ramirez, E
   Ibañez-Rodriguez, LJ
   Caroprese, O
   Buitrago-Lopez, A
AF Gómez-Neva, María Elizabeth
   Pulido-Ramirez, Edwin
   Ibañez-Rodriguez, Leidy Johana
   Caroprese, Oscar
   Buitrago-Lopez, Adriana
TI Non-pharmacological interventions for side effects of antineoplastic chemotherapy 
SO Revista Cuidarte
LA English
DT Journal Article
DE Complementary Therapies; Drug-Related Side Effects and Adverse Reactions; Integrative Oncology; Signs and Symptoms
AB INTRODUCTION: Different non-pharmacological interventions have been studied to 
   manage symptoms derived from chemotherapy, but their effectiveness is unknown. 
   OBJECTIVE: To describe non-pharmacological interventions for managing symptoms 
   secondary to antineoplastic chemotherapy in adults. MATERIALS AND METHODS: 
   Systematic review of analytical experimental and observational studies (2021 to 
   2023). The studies were selected, and data was extracted in parallel. 
   Discrepancies were resolved with a third reviewer. The risk of bias was assessed 
   using the Risk of Bias (RoB) tool and The Newcastle-Ottawa Scale (NOS). The 
   literature was synthesized descriptively based on prioritized outcomes. RESULTS: 
   The prioritized outcomes were neutropenia, pain, neuropathy, nausea, vomiting, 
   alopecia, anorexia, and sleep disorders. Out of 7520 references found, 62 were 
   included for analysis. Acupressure showed a possible effect in controlling 
   symptoms such as nausea and vomiting. The intervention with cold on the scalp 
   showed differences in the stages of alopecia severity. Other interventions showed 
   heterogeneity. DISCUSSION: Non-pharmacological interventions have been widely 
   described in observational and experimental studies in the control of side 
   effects of chemotherapy; however, there is homogeneity and a high risk of bias. 
   CONCLUSION: Acupressure, muscle massage, music therapy, foot baths, and other 
   interventions have been studied for nausea, vomiting, sleep disorders, 
   neutropenia, alopecia, anorexia, pain, and neuropathy as secondary symptoms 
   prioritized by patients. It is necessary to standardize both the interventions 
   and how measure the outcomes.
C1 Pontificia Universidad Javeriana, Facultad de Enfermería. Bogotá, Colombia. E-mail: m.gomezn@javeriana.edu.co Pontificia Universidad Javeriana PontificiaUniversidad Javeriana Facultad de Enfermería Bogotá Colombiam.gomezn@javeriana.edu.co.
   Pontificia Universidad Javeriana. Departamento de Epidemiología Clínica y Bioestadística, Facultad de Medicina. Bogotá, Colombia. E-mail:pulidoedwin@javeriana.edu.co Pontificia Universidad Javeriana PontificiaUniversidad Javeriana Departamento de Epidemiología Clínica y BioestadísticaFacultad de Medicina Bogotá Colombia pulidoedwin@javeriana.edu.co.
   Hospital Universitario San Ignacio. Bogotá, Colombia. E-mail: leidy.ibanez@javeriana.edu.co Hospital Universitario San Ignacio Bogotá Colombialeidy.ibanez@javeriana.edu.co.
   Subred Integrada de Servicios de Salud Norte. Bogotá, Colombia. E-mail: ocaropresse@g mail.com Subred Integrada de Servicios de Salud Norte BogotáColombia ocaropresse@g mail.com.
   Pontificia Universidad Javeriana, Departamento de Epidemiología Clínica y Bioestadística, Facultad de Medicina. Bogotá, Colombia. E-mail:buitragod@javeriana.edu.co Pontificia Universidad Javeriana PontificiaUniversidad Javeriana Departamento de Epidemiología Clínica y BioestadísticaFacultad de Medicina Bogotá Colombia buitragod@javeriana.edu.co.
NR 0
TC 0
SN 2346-341
EI 2216-097
J9 Rev Cuid
PD MAR 21
PY 2025
VL 15
IS 3
BP e3612
EP e3612
DI 10.15649/cuidarte.3612 
PG 1
UT PubMed:40115309
PM 40115309
DA 2025-03-21
ER

PT J
AU Li, J
   Xu, D
   Liu, Y
   Cao, Y
   He, J
   Liao, M
AF Li, Jialing
   Xu, Danghan
   Liu, Yingyu
   Cao, Yang
   He, Jun
   Liao, Muxi
TI Acupuncture Treatment of Guillain-Barré Syndrome After Using Immune Checkpoint 
SO Frontiers in neurology
LA English
DT Journal Article
DE Guillain–Barré syndrome; acupuncture; case report; immune checkpoint inhibitors; immune-related adverse events; limb weakness; numbness
AB Guillain-Barré syndrome(GBS) is an autoimmune-mediated peripheral neuropathy. 
   Immune checkpoint inhibitors (ICIs) are the standard treatment for cancer and may 
   lead to immune-related adverse events (irAEs) such as GBS. Corticosteroids, 
   plasma exchange (PE), and intravenous immunoglobulin (IVIG) are currently 
   accepted treatments for ICI-induced GBS. However, there are still adverse 
   reactions, and the effect of relieving symptoms is not as good as expected. Safe 
   and effective complementary replacement therapy to alleviate GBS symptoms and 
   ameliorate the quality of life is urgently required. In this case, a 63-year-old 
   man received ICI therapy and antitumor chemotherapy for lung malignancy. After 
   two courses of treatment, the patient gradually developed limb weakness, 
   numbness, and pain at the ends of the limbs, with cerebrospinal fluid (CSF) 
   albuminocytological dissociation, and electromyography (EMG) suggested 
   demyelinating changes and was diagnosed as GBS. Although the patient received 
   high doses of intravenous gamma globulin and limb weakness symptoms were 
   alleviated, there was still significant numbness and pain in the extremities. 
   After four times of acupuncture treatments, the patient complained that the 
   symptoms of limb numbness and fatigue were significantly alleviated without any 
   discomfort. This case report may provide a new alternative and complementary 
   therapy for immune checkpoint inhibitor-induced GBS, but more definitive and 
   robust evidence is needed to support its efficacy.
C1 The First Clinical School of Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine,Guangzhou, China.
   The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
   Guangdong Provincial Key Laboratory of Traditional Chinese Medicine and 
   Acupuncture and Rehabilitation Clinical School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
   The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
   The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
   The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
NR 0
TC 0
SN 1664-229
EI 1664-229
J9 Front Neurol
PD JUN 21
PY 2022
VL 13
IS 
BP 908282
EP 908282
DI 10.3389/fneur.2022.908282 
PG 0
UT PubMed:35720101
PM 35720101
DA 2022-06-21
ER

PT J
AU Liu, Q
   Qin, X
   Luo, C
   Zhao, Z
   Xie, W
   Du, X
   Qin, X
AF Liu, Qiang
   Qin, Xiaoguang
   Luo, Chenglin
   Zhao, Zhongting
   Xie, Wangjun
   Du, Xiaozheng
   Qin, Xin
TI Effects of warm needle acupuncture on behavioral pain threshold in a rat model of 
SO Frontiers in neurology
LA English
DT Journal Article
DE 5-HT; CGRP; ET-1 protein; migraine; needle warming acupuncture
AB BACKGROUND: As a traditional Chinese treatment method, acupuncture has a long 
   history in the treatment of migraine and a rich literature base. As a traditional 
   acupuncture technique, warm needle acupuncture has clearly demonstrated clinical 
   efficacy in the treatment of migraine, although its mechanism of action remains 
   unclear. This study aimed to evaluate the efficacy and safety of warm needle 
   acupuncture in the treatment of migraine in a rat model of migraine by comparing 
   pain threshold and analgesic-related factors among different groups. METHODS: 
   Thirty Sprague-Dawley rats were randomly divided into control, model, and 
   acupuncture groups, with 10 animals in each group. On day 8, rat migraine models 
   were established by subcutaneous injection of nitroglycerin. The acupuncture 
   group was bilaterally needled once per day at Fengchi, Baihui, Fengfu, and Hegu. 
   Behavioral changes and biochemical alterations among the rats before and after 
   modeling were observed for 7 consecutive days after treatment. The expression of 
   Endothelin-1 (ET-1), interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-α) 
   in the brain stem of the animals were assessed using ELISA. Expression levels of 
   calcitonin gene-related peptide (CGRP) mRNA were determined using real-time 
   quantitative polymerase chain reaction techniques. RESULTS: After treatment, the 
   expression of ET-1, IL-6, TNF-α, and CGRP in the brain stem of the model group 
   was significantly increased compared with that of the control group (p < 0.05), 
   while the expression of IL-6, TNF-α, and CGRP in the brain stem of the 
   acupuncture group was decreased. CONCLUSION: Warm needle acupuncture reduced ET-1 
   protein levels and promoted the expression of neurotransmitters, such as 
   5-hydroxytryptamine, in migraine rat model animals. In addition, needle warming 
   acupuncture decreased IL-6, TNF-α, and CGRP levels in the brain stem of the 
   migraine group, which may explain its mechanism of action in treating migraine.
C1 Department of Acupuncture and Moxibustion, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
   Department of Acupuncture and Moxibustion, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
   Department of Acupuncture and Moxibustion, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
   Department of Acupuncture and Moxibustion, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
   Department of Acupuncture and Moxibustion, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
   Department of Acupuncture and Moxibustion, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
   Medical Faculty, Northwest Minzu University, Lanzhou, China.
NR 0
TC 0
SN 1664-229
EI 1664-229
J9 Front Neurol
PD OCT 17
PY 2025
VL 16
IS 
BP 1538182
EP 1538182
DI 10.3389/fneur.2025.1538182 
PG 0
UT PubMed:41103513
PM 41103513
DA 2025-10-17
ER

PT J
AU Ma, WG
   Si, YX
   Zhang, YL
   Gao, WF
   Dong, YG
   Li, YQ
   Xu, ZF
   Xi, Q
   Li, ZZ
AF Ma, Wei-Gang
   Si, Yu-Xin
   Zhang, Yong-Long
   Gao, Wei-Fang
   Dong, Yu-Ge
   Li, Yan-Qi
   Xu, Zhi-Fang
   Xi, Qiang
   Li, Zhong-Zheng
TI Combining acupuncture and mesenchymal stem cell therapy offers promise as a 
SO World journal of stem cells
LA English
DT Review
DE Acupuncture; Anti-inflammatory; Inflammatory bowel disease; Mesenchymal stem cell; Oxidative stress
AB Inflammatory bowel disease (IBD) is a persistent gastrointestinal ailment driven 
   by a range of immunological and pathophysiological factors, and often exposes 
   patients to persistent pain and a greater risk of tumor development. In clinical 
   settings, sulfasalazine is among the most common treatments used to manage IBD, 
   but such treatment can result in a range of side effects in addition to leading 
   to relatively poor efficacy. In certain refractory cases, patients must undergo 
   surgical resection of affected tissues, underscoring the need to devise safer and 
   more efficacious forms of alternative treatment. Mesenchymal stem cells (MSCs) 
   have recently been shown to exhibit been shown to exhibit robust immunomodulatory 
   activity and potential for differentiation such that they may be an effective 
   tool for treating IBD. Acupuncture has also shown promise as an efficacious 
   treatment option for IBD, performing better than drug-based treatments in certain 
   clinical trials. Acupuncture is capable of enhancing endogenous MSC proliferation 
   and homing, enabling these cells to more effectively migrate toward target lesion 
   sites and to promote tissue repair. In light of these findings, this review was 
   formulated to survey the potential therapeutic advantages of combining MSCs and 
   acupuncture when attempting to treat IBD.
C1 Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Department of Clinical Practice, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Department of Clinical Practice, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
   Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, School of Acupuncture and Tuina, Tianjin 301617,China. lizhzh2008@163.com.
NR 0
TC 0
SN 1948-021
EI 1948-021
J9 World J Stem Cells
PD JUL 31
PY 2025
VL 17
IS 7
BP 105371
EP 105371
DI 10.4252/wjsc.v17.i7.105371 
PG 0
UT PubMed:40740536
PM 40740536
DA 2025-07-31
ER

PT J
AU Ho, EY
   Agne, RR
   Santana, T
   Thompson, N
   McClendon, G
   Ng, E
   Merrick, S
   Gonzalez, F
   Smith, T
   Drewke, K
   Gutierrez, A
   Floyd, G
   Chao, MT
AF Ho, Evelyn Y
   Agne, Robert R
   Santana, Trilce
   Thompson, Nicole
   McClendon, Genevieve
   Ng, Eliza
   Merrick, Shannette
   Gonzalez, Felicia
   Smith, Tenaya
   Drewke, Kathleen
   Gutierrez, Amalia
   Floyd, Gary
   Chao, Maria T
TI A Communication Perspective on What Patient Advisory Boards Do: 
SO Journal of general internal medicine
LA English
DT Journal Article
DE acupuncture; cancer; implementation; inpatient; pain; pragmatic effectiveness
AB Stakeholder advisory boards are recognized as an essential and useful part of 
   patient-centered research. However, such engagement can involve exchanges of 
   diverse individual experiences, multiple opinions, and strong feelings in the 
   face of researchers' limitations, deadlines, and agendas. Yet, little work 
   examines how these potential tensions occur and are resolved in actual advisory 
   board meetings. This perspective article describes and employs a communication 
   framework for analyzing a patient advisory council (PAC) for a comparative 
   effectiveness study on acupuncture and pain counseling for inpatients with 
   cancer. The framework, Action-Implicative Discourse Analysis (AIDA), is an 
   observational method that examines challenges through recorded and transcribed, 
   naturally occurring interaction. Our analysis focused on two short excerpts from 
   the first PAC meeting to demonstrate members' navigation of advice-giving and 
   advice-receiving-one in which advice was ultimately implemented by the study team 
   and another in which it was deemed unfeasible. Although advice is inherent to the 
   work of all PACs, it often emerges unannounced as negotiated moments, made up of 
   seemingly minor conversation moves. As a recurring event, advice can and should 
   be analyzed and discussed within PACs to improve communication and team dynamics.
C1 Department of Communication Studies, University of San Francisco, 2130 Fulton Street, Communication Studies KA 313, San Francisco, CA, 94117, USA.eyho@usfca.edu.
   Asian American Research Center on Health, University of California, San Francisco 
   Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services Advisory Board, San Francisco, CA, USA. eyho@usfca.edu.
   School of Communication and Journalism, Auburn University, Auburn, AL, USA.
   Osher Center for Integrative Medicine, UCSF, San Francisco, CA, USA.
   Osher Center for Integrative Medicine, UCSF, San Francisco, CA, USA.
   Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services Advisory Board, San Francisco, CA, USA.
   Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services Advisory Board, San Francisco, CA, USA.
   Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services Advisory Board, San Francisco, CA, USA.
   School of Medicine, University of California Davis, Davis, CA, USA.
   Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services Advisory Board, San Francisco, CA, USA.
   Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services Advisory Board, San Francisco, CA, USA.
   Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services Advisory Board, San Francisco, CA, USA.
   Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services Advisory Board, San Francisco, CA, USA.
   Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services Advisory Board, San Francisco, CA, USA.
   Asian American Research Center on Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.
   Osher Center for Integrative Medicine, UCSF, San Francisco, CA, USA.
   Department of Medicine, Division of General Internal Medicine at San Francisco General Hospital, UCSF, San Francisco, CA, USA.
NR 0
TC 0
SN 1525-149
EI 0884-873
J9 J Gen Intern Med
PD OCT 1
PY 2021
VL 37
IS Suppl 1
BP 99
EP 104
DI 10.1007/s11606-021-07062-3 
PG 5
WC Communication; Counseling; Humans; Inpatients; Negotiating
UT PubMed:34591265
PM 34591265
DA 2021-10-01
ER

PT J
AU Gamus, D
AF Gamus, Dorit
TI [Advances in research of complementary and integrative medicine: a review of 
SO Harefuah
LA heb
DT Review
AB This article assesses the evidence for effectiveness, adverse effects and 
   cost-effectiveness of complementary therapies, as reflected in publications in 
   high impact factor medical journals during the years 2012-2014. The search 
   detected 13 randomized controlled studies (RCTs) and 14 meta-analyses, which 
   collectively assessed results of 191 RCTs involving the participation of several 
   thousand patients. Pain was the major focus of acupuncture research in both 
   clinical and fMRI studies, which demonstrated that the effect of acupuncture is 
   beyond the placebo effect. In addition, RCTs supported the use of acupuncture as 
   an adjunctive therapy in chronic obstructive pulmonary disease and in moderate to 
   severe depression. A promising trend was reported for the ameliorating effect of 
   acupuncture in gout. Spinal manipulations may be helpful in cervical pain and 
   yoga may be a useful treatment option for chronic neck pain, chronic low back 
   pain and for pain-related disability. Beneficial effects of adding hypnosis and 
   massage therapy to the treatment of fibromyalgia patients were also documented. 
   Tai-chi may reduce balance impairment in mild-to-moderate Parkinson's disease and 
   improve symptoms in patients with osteoarthritis. Products containing cranberry 
   are associated with protective effects in some subgroups of patients with 
   recurrent urinary tract infections. Chinese herbs may assist in glycemic control 
   of diabetes patients and improve survival rate of patients with non-small cell 
   lung cancer. Some of the complementary therapies were found to be cost-effective. 
   Physicians should be aware of the possible adverse effects of these treatments 
   and of possible drug-herb interactions. Further larger scale trials are 
   justified.
NR 0
TC 0
SN 
EI 0017-776
J9 Harefuah
PD MAR 24
PY 2015
VL 154
IS 1
BP 9
EP 15, 70
DI 
PG 1
WC Complementary Therapies; adverse effects; Cost-Benefit Analysis; Humans; Integrative Medicine; methods; Randomized Controlled Trials as Topic
UT PubMed:25796668
PM 25796668
DA 2015-03-24
ER

PT J
AU Lam, WC
   Zhong, L
   Liu, Y
   Shi, N
   Ng, B
   Ziea, E
   Bian, Z
   Lu, A
AF Lam, Wai Ching
   Zhong, Linda
   Liu, Yuqi
   Shi, Nannan
   Ng, Bacon
   Ziea, Eric
   Bian, Zhaoxiang
   Lu, Aiping
TI Hong Kong Chinese Medicine Clinical Practice Guideline for Cancer Palliative 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB It is common for patients with cancers in Hong Kong seeking Chinese Medicine (CM) 
   therapies as supportive care during cancer treatment and to manage 
   treatment-related side effects. This article provides clinical practice guideline 
   (CPG) on the use of CM for specific clinical indications caused by cancer and 
   during cancer treatment, including pain, constipation, and insomnia, and aims to 
   guide local licensed CM practitioners and provide beneficial reference for social 
   medical decision makers and patients. In this manuscript, we summarize the 
   clinical manifestation, CM pattern classification, and CM intervention including 
   herbal treatment, acupuncture treatment, regulating, and nursing based on pattern 
   differentiation.
C1 Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Kowloon 999077, Hong Kong.
   Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Kowloon 999077, Hong Kong.
   China Academy of Chinese Medical Science, Beijing 100700, China.
   China Academy of Chinese Medical Science, Beijing 100700, China.
   Department of Chinese Medicine, Hong Kong Hospital Authority, Kowloon 999077, Hong Kong.
   Department of Chinese Medicine, Hong Kong Hospital Authority, Kowloon 999077, Hong Kong.
   Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Kowloon 999077, Hong Kong.
   Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Kowloon 999077, Hong Kong.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD FEB 26
PY 2019
VL 2019
IS 
BP 1038206
EP 1038206
DI 10.1155/2019/1038206 
PG 0
UT PubMed:30805017
PM 30805017
DA 2019-02-26
ER

PT J
AU Schnyer, RN
   Hullender, Rubin L
AF Schnyer, Rosa N
   Hullender Rubin, Lee
TI Overcoming Barriers in Clinical Acupuncture Research: Translating Clinical 
SO Medical acupuncture
LA English
DT Journal Article
DE acupuncture; chronic illness management; dose response; hypothesis-driven outcomes; interprofessional teams
AB Background: The translation of clinical practice into research presents unique 
   challenges. This is especially the case in evaluating the effect of interventions 
   in the management of chronic conditions such as pain, mental health, substance 
   misuse, and oncology care. Chronic complex conditions might respond to different 
   strategies at different points in time and may require an interdisciplinary 
   approach to treatment. Objectives: To define the key barriers to the design, 
   implementation, and evaluation of clinical trials of acupuncture that derive from 
   a unidirectional translational research strategy. Results: Critical challenges to 
   the design, implementation, and evaluation of clinical trials of acupuncture 
   center around four areas: (1) insufficient early phase research, (2) suboptimal 
   treatment protocols, (3) inadequate research questions, and 4) a narrowed 
   assessment of outcomes. Conclusions: By promoting research priorities that 
   reflect the complex nature of chronic illness, we can more clearly articulate 
   research questions that better reflect clinical practice, while evaluating the 
   impact of acupuncture in patient care. Key priorities include phase I research 
   funding opportunities, pragmatic trials that evaluate acupuncture embedded in 
   interprofessional teams, and the inclusion of hypothesis-driven secondary 
   outcomes.
C1 School of Nursing, University of Texas, Austin, TX, USA.
   Osher Center for Integrative Medicine, University of California, San Francisco, San Francisco, CA, USA.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD DEC 29
PY 2020
VL 32
IS 6
BP 388
EP 390
DI 10.1089/acu.2020.1479 
PG 2
UT PubMed:33362894
PM 33362894
DA 2020-12-29
ER

PT J
AU Li, H
   Wang, B
   Chen, C
AF Li, Hanjing
   Wang, Biao
   Chen, Chuanyuan
TI Acupuncture around the greater tuberosity of the femur combined with acupuncture 
SO American journal of translational research
LA English
DT Journal Article
DE Greater tuberosity of the femur; Xuehai acupoint; intertrochanteric fracture; pain
AB OBJECTIVE: To determine the efficacy of acupuncture around the greater tuberosity 
   of the femur (AGTF) combined with acupuncture at Xuehai acupoint for 
   postoperative pain in elderly patients with intertrochanteric fracture. METHODS: 
   A total of 97 elderly patients with intertrochanteric fracture treated by 
   proximal femoral nail antirotation (PFNA) were enrolled and randomly assigned 
   into an observation group (Obs group, n=48) and a control group (Con group, 
   n=49). The Obs group was treated by aspirin and AGTF combined with acupuncture at 
   Xuehai acupoint for analgesia, while the Con group was treated by aspirin alone 
   for analgesia. Both groups were treated for 7 consecutive days. The two groups 
   were compared in pain degree (visual analog scale (VAS) score) after operation 
   and hip joint function (Harris score), daily living ability (modified Barthel 
   index (MBI) score), bone metabolism-related indexes, and inflammatory factors 
   before and after treatment. RESULTS: At 1-7 d after operation, both groups had 
   gradually lower VAS scores, and at 5 and 7 d after operation, the Obs group had a 
   lower VAS score than the Con group (both P<0.05). Additionally, at 2 months after 
   operation, both groups had higher Harris scores and MBI scores, and the scores of 
   the Obs group were both higher than those of the Con group (both P<0.05). At 7 d 
   after operation, both groups showed a decrease in serum beta collagen degradation 
   products (β-CTx) and an increase in procollagen type I amino-terminal propeptide 
   (PINP) (both P<0.05), but the differences between the two groups in β-CTx and 
   PINP were insignificant (P>0.05). Moreover, at 7 d after operation, both groups 
   showed a decrease in C-reactive protein (CRP) and tumor necrosis factor-α 
   (TNF-α), and the two levels in the Obs group were lower than those in the Con 
   group (both P<0.05). CONCLUSION: For elderly patients with intertrochanteric 
   fracture, AGTF combined with acupuncture at the Xuehai acupoint can more 
   effectively relieve their postoperative pain and postoperative inflammation and 
   more strongly promote their postoperative recovery of hip joint function.
C1 Department of Traditional Chinese Medicine, Fuzhou Second Hospital Affiliated to Xiamen University Fuzhou, Fujian Province, China.
   Department of Orthopedics, Fuzhou Second Hospital Affiliated to Xiamen University Fuzhou, Fujian Province, China.
   Department of Orthopedics, Fuzhou Second Hospital Affiliated to Xiamen University Fuzhou, Fujian Province, China.
NR 0
TC 0
SN 1943-814
EI 1943-814
J9 Am J Transl Res
PD AUG 12
PY 2021
VL 13
IS 7
BP 8372
EP 8378
DI 
PG 6
UT PubMed:34377330
PM 34377330
DA 2021-08-12
ER

PT J
AU Shan, Y
   Zhang, J
   Ma, Y
   Zhang, Y
AF Shan, Yunping
   Zhang, Juan
   Ma, Yinhua
   Zhang, Yiming
TI The effects of acupuncture combined with western medicine in the treatment of 
SO American journal of translational research
LA English
DT Journal Article
DE Neck shoulder low back pain; acupuncture treatment; inflammatory factors; motor functions; symptom improvement
AB OBJECTIVE: To investigate the effect of Traditional Chinese Medicine (TCM) 
   acupuncture combined with western medicine in the treatment of neck, shoulder, 
   lumbar and leg pain and its influence on the degree of pain, motor functions and 
   inflammatory factor levels. METHODS: In this retrospective study, 86 patients 
   with neck, shoulder, lumbar and leg pain treated in Department of Orthopedics and 
   Traumatology, Hangzhou Fuyang Hospital of TCM from June 2019 to June 2022 were 
   selected as the study subjects. According to different treatment methods, these 
   patients were divided into an observation group (n=43) and a control group 
   (n=43). Patients from the control group were treated with conventional western 
   medicine, while those from the observation group were treated with combination of 
   traditional Chinese medicine acupuncture (Acupuncture + Fumigation with 
   Collaterals-Dredging Decoction) and western medicine. Patients in both groups 
   were treated for 4 weeks continuously. The treatment effect, visual analogue 
   scale (VAS) score, limb motor function scale (Fugl-Meyer) score, cervical 
   function score, daily living ability score, the levels of inflammatory factors 
   including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive 
   protein (CRP) were recorded and compared between two groups. RESULTS: The 
   effective rate of patients in the observation group was 93.02%, which was 
   significantly higher than 76.74% in the control group (P<0.05). There was no 
   significant difference in the term of Fugl-Meyer score, VAS score and levels of 
   inflammatory factors before treatment between two groups (all P>0.05). After 
   treatment, the VAS score and the levels of IL-6, TNF-α and CRP in both of groups 
   significantly decreased in contrast to before treatment. The Fugl-Meyer score 
   after treatment in both of groups was significantly increased in contrast to 
   before treatment. Compared with those after treatment in control group, the VAS 
   score and the levels of IL-6, TNF-α and CRP after treatment in the observation 
   group were obviously lower, while the Fugl-Meyer score in the observation group 
   was significantly higher (all P<0.05). CONCLUSION: TCM acupuncture combined with 
   western medicine has a good therapeutic effect on neck, shoulder, lumbar and leg 
   pains, which can effectively relieve the pain, improve motor function and reduce 
   the inflammatory reactions in patients. The combined treatment has clinical 
   application values and is worth promoting.
C1 Department of Pain Treatment, Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology Hangzhou, Zhejiang, China.
   Department of Pain Treatment, Zhejiang Provincial Hospital of TCM Hangzhou, Zhejiang, China.
   Department of Pain Treatment, Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology Hangzhou, Zhejiang, China.
   Orthopedics and Traumatology Department, Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology Hangzhou, Zhejiang, China.
NR 0
TC 0
SN 1943-814
EI 1943-814
J9 Am J Transl Res
PD JUL 12
PY 2023
VL 15
IS 6
BP 4246
EP 4254
DI 
PG 8
UT PubMed:37434859
PM 37434859
DA 2023-07-12
ER

PT J
AU Klose, P
   Voiß, P
   Voswinkel, M
   Reumkens, E
AF Klose, Petra
   Voiß, Petra
   Voswinkel, Martje
   Reumkens, Eva
TI [Palliative medicine and integrative medicine as complementary approaches in 
SO Urologie (Heidelberg, Germany)
LA ger
DT Review
DE Cancer; Depression; Early Integration; Quality of life; Symptom management
AB BACKGROUND: Uro-oncological diseases have negative long-term consequences for 
   physical, functional, psychological, and socioeconomic well-being. A common focus 
   of palliative and integrative medicine is improving quality of life by 
   alleviating symptoms. OBJECTIVES: What treatment options are available for 
   frequently occurring symptoms in uro-oncology patients? METHODS: Based on current 
   literature and international guideline recommendations, an overview of palliative 
   and integrative medical therapies and their significance in the management of 
   advanced uro-oncological tumors is given. RESULTS: Palliative care treatment 
   options combined with complementary medicine can effectively contribute to 
   symptom relief. The foundation of tumor pain therapy is medication, which can be 
   effectively supplemented with acupuncture, for example. Medication and relaxation 
   exercises can also have synergistic effects on sleep disorders. 
   A multiprofessional and interdisciplinary approach is also beneficial for the 
   treatment of anxiety and depression, combining medication, psycho-oncological 
   support, physiotherapy, social services, nutritional therapy, mindfulness 
   exercises, meditative movement exercises, and so on. It is important that 
   palliative and integrative medical support be offered early in the course of the 
   illness. This support includes not only optimizing symptom relief but also 
   communication with patients and their families and caregivers. CONCLUSION: 
   Palliative medicine and integrative medicine offer the chance to improve the 
   quality of life and symptom management in advanced uro-oncological cancer.
C1 Klinik für Integrative Onkologie & Supportivmedizin, KEM, Evang. Kliniken Essen-Mitte, Essen, Deutschland.
   Klinik für Integrative Onkologie & Supportivmedizin, KEM, Evang. Kliniken Essen-Mitte, Essen, Deutschland.
   Klinik für Palliativmedizin, KEM, Evang. Kliniken Essen-Mitte, Evang. Huyssens-Stiftung Essen-Huttrop, Henricistraße 92, 45136, Essen, Deutschland.
   Klinik für Palliativmedizin, KEM, Evang. Kliniken Essen-Mitte, Evang. Huyssens-Stiftung Essen-Huttrop, Henricistraße 92, 45136, Essen, Deutschland.palliativmedizin@kem-med.com.
NR 0
TC 0
SN 2731-707
EI 
J9 Urologie
PD JAN 13
PY 2026
VL 0
IS 
BP 
EP 
DI 10.1007/s00120-025-02745-9 
PG 0
UT PubMed:41528449
PM 41528449
DA 2026-01-13
ER

PT J
AU Gao, J
   Yuan, YS
   Liu, T
   Lv, HR
   Xu, HL
AF Gao, Jie
   Yuan, Yu-Song
   Liu, Ting
   Lv, Hao-Run
   Xu, Hai-Lin
TI Synovial sarcoma in the plantar region: A case report and literature review.
SO World journal of clinical cases
LA English
DT Journal Article
DE Case report; Imaging examination; Pathological examination; Plantar; Synovial sarcoma
AB BACKGROUND: Synovial sarcoma (SS), a rare malignant soft tissue tumor whose 
   histological origin is still unknown, often occurs in limbs in young people and 
   is easily misdiagnosed. CASE SUMMARY: We report a 24-year-old man who sought 
   treatment for plantar pain thought to be caused by a foot injury that occurred 4 
   years prior. Currently, he had been seen at another hospital for a 1-wk history 
   of unexplained pain in the left plantar region and was treated with acupuncture, 
   a kind of therapy of Chinese medicine, which partly relieved the pain. Because of 
   this, the final diagnosis of biphasic SS was made after two subsequent treatments 
   by pathological evaluation after the last operation. SS is rarely seen in the 
   plantar area, and his history of a left plantar injury confused the original 
   diagnosis. CONCLUSION: This study shows that pathological and imaging 
   examinations may play a vital role in the early diagnosis and treatment of SS.
C1 Pingxiang Health Vocational College, Pingxiang Medical School, Pingxiang 337000, Jiangxi Province, China.
   Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing 100044, China.
   Pingxiang Health Vocational College, Pingxiang Medical School, Pingxiang 337000, Jiangxi Province, China.
   Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing 100044, China.
   Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing 100044, China.
NR 0
TC 0
SN 2307-896
EI 2307-896
J9 World J Clin Cases
PD SEP 29
PY 2019
VL 7
IS 17
BP 2549
EP 2555
DI 10.12998/wjcc.v7.i17.2549 
PG 6
UT PubMed:31559291
PM 31559291
DA 2019-09-29
ER

PT J
AU Zhu, XY
   Li, Z
   Chen, C
   Feng, RL
   Cheng, BR
   Liu, RY
   Wang, RT
   Xu, L
   Wang, Y
   Tao, X
   Zhao, P
AF Zhu, Xue-Ying
   Li, Zhong
   Chen, Cong
   Feng, Ru-Li
   Cheng, Bai-Ru
   Liu, Ruo-Yi
   Wang, Rui-Ting
   Xu, Li
   Wang, Yue
   Tao, Xin
   Zhao, Peng
TI Physical Therapies for Psychosomatic Symptoms and Quality of Life Induced by 
SO Frontiers in oncology
LA English
DT Journal Article
DE acupuncture; aromatase inhibitors; breast cancer; exercise; pain; physical therapies; quality of life
AB OBJECTIVE: To evaluate the effects of Physical Therapies (PTs) on improvement in 
   psychosomatic symptoms and quality of life (QOL) in breast cancer patients. DATA 
   SOURCES: Seven databases (MEDLINE, EMBASE, Cochrane CENTRAL, China National 
   Knowledge Infrastructure, Wangfang, VIP, and China Biology Medicine disc 
   databases) were systematically searched from the database inception through May 
   18, 2021. STUDY SELECTION: Randomized controlled trials (RCTs) which compared 
   acupuncture or exercise with a sham control or usual care for the treatment of 
   aromatase inhibitors (AIs)-related psychosomatic symptoms and QOL. DATA 
   EXTRACTION AND SYNTHESIS: Data were screened and extracted independently using 
   predesigned forms. The quality of RCTs was assessed with the Cochrane Handbook 
   for Systematic Reviews of Interventions. The effect size was calculated via 
   random-effects modeling. The quality of evidence was evaluated with the Grading 
   of Recommendations Assessment, Development and Evaluation approach. MAIN OUTCOMES 
   AND MEASURES: The score of pain was measured with BPI scale and Western Ontario 
   and the McMaster Universities Index (WOMAC) scale. Emotional state was measured 
   with Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale 
   (HADS-A), and Functional Assessment of Chronic Illness Therapy-Fatigue 
   (FACIT-Fatigue). The QOL score was measured by self-reported measurements, 
   including the Functional Assessment of Cancer Therapy-General (FACT-G) scale and 
   36-Item Short Form Survey (SF-36) scale. RESULTS: Eleven RCTs (with 830 patients) 
   were included in the systematic review, and data from 10 RCTs (with 798 patients) 
   were used in the meta-analysis. Results showed acupuncture significantly reduced 
   worst pain scores (P < 0.00001, I (2) = 83.5%) [SMD = -0.81, 95% CI (-1.51, 
   -0.11)], but the effect of exercise therapies was not significant in overall 
   change in worst pain scores (P =0.006, I (2) = 72.3%) [SMD = -0.30, 95% CI 
   (-0.76, 0.16)]. Both acupuncture and exercise resulted in little to no difference 
   in overall change in HADS-A subscale (P = 0.026<0.05, I (2) = 79.8%) 
   [WMD = -0.21, 95% CI (-3.44, 3.03)], PSQI subscale (P = 0.488, I (2) = 0%) 
   [WMD = 0.98, 95% CI (-0.57, 2.53)], and FACIT-Fatigue subscale (P = 0.022<0.05, I 
   (2) = 81.0%) [WMD = 1.6, 95% CI (-5.75, 8.94)]. Exercise (compared with usual 
   care) was associated with improving overall change in health-related QOL 
   (subscales of SF-36 tool) (P = 0, I (2) = 72.1%) [WMD = 7.97, 95% CI (5.68, 
   10.25)] and cancer-specific QOL (subscales of FACT-G tool) (P = 0.304, I 
   (2) = 16%) [WMD = 1.16, 95% CI (0.34, 1.97)]. CONCLUSIONS AND RELEVANCE: This 
   systematic review and meta-analysis suggested that based on moderate-level 
   evidence, acupuncture was associated with significant reductions in pain 
   intensity, and exercise might improve QOL in breast cancer patients treated with 
   AIs. However, in psychosomatic symptoms such as anxiety, sleep disturbance, and 
   fatigue, acupuncture and exercise training did not result in significant 
   improvements.
C1 Department of Oncology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   Department of Oncology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   Department of Encephalopathy, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   Department of Gynecology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
   Graduate School of Beijing University of Chinese Medicine, Beijing, China.
   School of Medical Humanities, Capital Medical University, Beijing, China.
   Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD DEC 7
PY 2021
VL 11
IS 
BP 745280
EP 745280
DI 10.3389/fonc.2021.745280 
PG 0
UT PubMed:34868943
PM 34868943
DA 2021-12-07
ER

PT J
AU Wang, Y
   Tao, S
   Yu, Z
   Luo, Y
   Li, Y
   Tang, J
   Chen, G
   Shuai, R
   Hu, X
   Wu, P
AF Wang, Yingni
   Tao, Siyu
   Yu, Zeyun
   Luo, Yun
   Li, Yuan
   Tang, Jie
   Chen, Guanhua
   Shuai, Rouxian
   Hu, Xinyue
   Wu, Ping
TI Effect of Moxibustion on β-EP and Dyn Levels of Pain-Related Indicators in 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB BACKGROUND: Rheumatoid arthritis (RA) is a systemic immunodeficiency disease 
   characterized by persistent synovial inflammation, pannus formation, and bone and 
   cartilage destruction, resulting in joint malformations and function decline. 
   OBJECTIVE: The purpose of this study is to evaluate the effect of moxibustion on 
   clinical symptoms and levels of pain-related indicators beta-endorphin (β-EP) and 
   dynorphin (Dyn) in patients with RA and to explore the potential 
   anti-inflammatory and analgesic mechanisms of moxibustion in RA treatment. 
   METHODS: A total of 64 patients with RA who met the inclusion criteria were 
   randomly and equally classified into the control and treatment groups. The 
   control group received conventional treatment (oral methotrexate, folate, or 
   leflunomide prescribed for a long time). The treatment group was treated with 
   moxibustion at ST36 (Zusanli), BL23 (Shenshu), and Ashi points with respect to 
   the control group. Patients' clinical symptoms and routine inspection indexes 
   (rheumatoid factor [RF], erythrocyte sedimentation rate [ESR], and C-reactive 
   protein [CRP]) were recorded before and after treatment. Serum levels of tumor 
   necrosis factor-α (TNF-α), interleukin-1β (IL-1β), β-EP, and Dyn were determined 
   by enzyme-linked immunosorbent assay (ELISA). The software SPSS24.0 was used for 
   statistical analysis. RESULTS: (1) Compared with the pretreatment result, both of 
   the two groups' clinical symptoms and routine inspection indexes (RF, ESR, and 
   CRP) improved (P < 0.05), and the improvement of clinical symptoms in the 
   treatment group outperformed that in the control group (P < 0.05). (2) TNF-α and 
   IL-1β levels decreased significantly in the treatment group after treatment 
   (P < 0.01), while no significant difference was observed in the control group 
   (P > 0.05). (3) β-EP and Dyn levels in the treatment group were significantly 
   increased after treatment (P < 0.01, P < 0.01), but the control group showed no 
   significant difference (P > 0.05, P > 0.05). It is worth mentioning that the 
   serum TNF-α, IL-1β, β-EP, and Dyn levels between the two groups were 
   significantly different after 8 weeks of treatment (P < 0.05). (4) Differences in 
   the serum β-EP and Dyn levels in the patients of the treatment group were 
   correlated with TNF-α and IL-1β levels after treatment, and the correlation was 
   mainly negative (r < 0). CONCLUSION: Moxibustion can improve joint pain in 
   patients with RA using conventional western medicine. One of the mechanisms may 
   affect the serum β-EP and Dyn levels by downregulating the inflammatory factors 
   to play an anti-inflammatory and analgesic role.
C1 Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu 610075, China.
   Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu 610075, China.
   Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu 610075, China.
   Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu 610075, China.
   Hospital of Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu 610075, China.
   Hospital of Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu 610075, China.
   Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu 610075, China.
   Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu 610075, China.
   Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu 610075, China.
   Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu 610075, China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD APR 23
PY 2021
VL 2021
IS 
BP 6637554
EP 6637554
DI 10.1155/2021/6637554 
PG 0
UT PubMed:33884025
PM 33884025
DA 2021-04-23
ER

PT J
AU Carannante, F
   Caricato, M
   Ripetti, V
AF Carannante, F
   Caricato, M
   Ripetti, V
TI The valdoni technique for bowel anastomosis. A rare complication.
SO Annals of medicine and surgery (2012)
LA English
DT Journal Article
DE Colon cancer; Ileocolic anastomose; Right emicolectomy; Surgery complications; Valdoni technique
AB BACKGROUND: Valdoni technique involves leaving the mucosa layer, between the two 
   anastomosed bowel tract intact, providing for a subsequent breakage of the 
   intestine. It is a technique that allows you to keep the operating field 
   clean.Surgical technique and Case Report: We describe the Valdoni technique. We 
   also report a case of 75 years old man affected by an ascending colon cancer with 
   no metastasis. The patient underwent right hemicolectomy. Making the anastomose, 
   the surgeon did the Valdoni technique, with no intraoperative complications.The 
   postoperative course was characterized by an abdominal pain with swollen abdomen, 
   no flatus and vomit. A computed tomography (CT) revealed a sub-stenosis of the 
   anastomose. We decided to do an urgent colonoscopy, with a resection of the 
   mucosa layer not totally opened, using a Needle-knife Precut. The post procedure 
   course was uneventful. The patient was discharged three days later. CONCLUSION: 
   Valdoni technique allows the surgeon to keep the operating field clean. It is a 
   valid alternative when the surgeons have to make a colonic anastomosis, doing 
   open surgery.
C1 Department of General Surgery, Università Campus Bio-Medico, Via Alvaro del Portillo 21, 00128, Rome, Italy.
   Department of General Surgery, Università Campus Bio-Medico, Via Alvaro del Portillo 21, 00128, Rome, Italy.
   Department of General Surgery, Università Campus Bio-Medico, Via Alvaro del Portillo 21, 00128, Rome, Italy.
NR 0
TC 0
SN 2049-080
EI 2049-080
J9 Ann Med Surg (Lond)
PD JUL 19
PY 2019
VL 44
IS 
BP 68
EP 71
DI 10.1016/j.amsu.2019.06.006 
PG 3
UT PubMed:31316770
PM 31316770
DA 2019-07-19
ER

PT J
AU Zhang, X
   Yang, W
   Shang, J
   Dan, W
   Shi, L
   Tong, L
   Yang, G
AF Zhang, Xu
   Yang, Wenjing
   Shang, Junliang
   Dan, Wenchao
   Shi, Lin
   Tong, Li
   Yang, Guowang
TI The lower He-sea points playing a significant role in postoperative ileus in 
SO Frontiers in oncology
LA English
DT Journal Article
DE acupuncture; association rules; colorectal cancer; machine-learning; postoperative ileus
AB BACKGROUND: Postoperative ileus (POI) is a common complication following 
   abdominal surgery, which can lead to significant negative impacts on patients' 
   well-being and healthcare costs. However, the efficacy of current treatments is 
   not satisfactory. The purpose of this study was to evaluate the therapeutic 
   effects of acupuncture intervention and explore the regulation of acupoint 
   selection for treating POI in colorectal cancer (CRC) patients. METHODS: We 
   searched eight electronic databases to identify randomized controlled trials 
   (RCTs) on acupuncture for POI in CRC and conducted a meta-analysis. Subsequently, 
   we utilized the Apriori algorithm and the Frequent pattern growth algorithm, in 
   conjunction with complex network and cluster analysis, to identify association 
   rules of acupoints. RESULTS: The meta-analysis showed that acupuncture led to 
   significant reductions in time to first defecation (MD=-20.93, 95%CI: -25.35, 
   -16.51; I(2 =) 93.0%; p < 0.01; n=2805), first flatus (MD=-15.08, 95%CI: -18.39, 
   -11.76; I(2 =) 96%; p < 0.01; n=3284), and bowel sounds recovery (MD=-10.96, 
   95%CI: -14.20, -7.72; I(2 =) 94%; p < 0.01; n=2043). A subgroup analysis revealed 
   that acupuncture not only reduced the duration of POI when administered alongside 
   conventional care but also further expedited the recovery of gut function after 
   colorectal surgery when integrated into the enhanced recovery after surgery 
   (ERAS) pathway. The studies included in the analysis reported no instances of 
   serious adverse events associated with acupuncture. We identified Zusanli (ST36), 
   Shangjuxu (ST37), Neiguan (PC6), Sanyinjiao (SP6), Xiajuxu (ST39), Hegu (LI4), 
   Tianshu (ST25), and Zhongwan (RN12) as primary acupoints for treating POI. 
   Association rule mining suggested potential acupoint combinations including 
   {ST37, ST39}≥{ST36}, {PC6, ST37}≥{ST36}, {SP6, ST37}≥{ST36}, and {ST25, 
   ST37}≥{ST36}. CONCLUSION: Meta-analysis indicates acupuncture's safety and 
   superior effectiveness over postoperative care alone in facilitating 
   gastrointestinal recovery. Machine-learning approaches highlight the importance 
   of the lower He-sea points, including Zusanli (ST36) and Shangjuxu (ST37), in 
   treating POI in CRC patients. Incorporating additional acupoints such as Neiguan 
   (PC6) (for pain and vomiting) and Sanyinjiao (SP6) (for abdominal distension and 
   poor appetite) can optimize treatment outcomes. These findings offer valuable 
   insights for refining treatment protocols in both clinical and experimental 
   settings, ultimately enhancing patient care.
C1 Department of Nutrition, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
   Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
   Department of Surgery, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
   School of Graduates, Capital Medical University, Beijing, China.
   Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
   Department of Nutrition, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
   Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD AUG 11
PY 2023
VL 13
IS 
BP 1206196
EP 1206196
DI 10.3389/fonc.2023.1206196 
PG 0
UT PubMed:37564931
PM 37564931
DA 2023-08-11
ER

PT J
AU Kotlyar, A
AF Kotlyar, Arkady
TI I Ching Balance Acupuncture Treatment of Migraines, Insomnia, and Depression in a 
SO Medical acupuncture
LA English
DT Journal Article
DE I Ching Balance Acupuncture (ICBA); depression; insomnia; integrative medicine; migraine; ovariectomy
AB Introduction: Surgical menopause is associated with symptoms that can affect a 
   woman's quality of life (QoL) significantly. These symptoms include migraines, 
   insomnia, and depression. Case: A 45-year-old Caucasian female presented at an 
   acupuncture clinic. Fourteen years prior, she had been diagnosed with ovarian 
   carcinoma, underwent ovariectomy, and was prescribed hormone replacement therapy. 
   Deteriorating QoL caused her to seek acupuncture for migraines, insomnia, and 
   depression. The outcomes sought for treatment of this case included intensity, 
   duration, and frequency of migraines, insomnia, and depression, as well as her 
   QoL. The outcome measures were estimated monthly throughout her treatment. Each 
   was rated on a numeric scale of 0-10 (0 = "the lowest possible" and 10 = "the 
   worst imaginable"). At baseline, the patient rated the intensity, duration, and 
   frequency of each complaint as 10. She was treated with 60-minute, I Ching 
   Balance Acupuncture (ICBA) sessions once per week for 7 months. Results: This 
   acupuncture treatment did not cause any adverse events, pain, or discomfort. Her 
   migraines, insomnia, and depression decreased to a great extent. In addition, 
   this patient reported considerable improvement in her QoL. The improvement in her 
   QoL was inversely related to the intensity, duration, and frequency of her 
   complaints throughout her acupuncture treatment. Conclusions: This patient 
   reported a considerable improvement in all the outcome measures. She completed 
   the treatment after experiencing great improvement in her QoL. Additional, 
   larger-scale studies are warranted to investigate the effects of ICBA.
C1 Outpatient Pain Clinic, Kaplan Medical Center, Rehovot, Israel.
NR 0
TC 0
SN 1933-659
EI 1933-658
J9 Med Acupunct
PD FEB 8
PY 2018
VL 30
IS 1
BP 41
EP 45
DI 10.1089/acu.2017.1249 
PG 4
UT PubMed:29410721
PM 29410721
DA 2018-02-08
ER

PT J
AU Silva, JG
   Santana, CG
   Inocêncio, KR
   Orsini, M
   Machado, S
   Bergmann, A
AF Silva, Julio Guilherme
   Santana, Camila Gonçalves
   Inocêncio, Kelly Rosane
   Orsini, Marco
   Machado, Sergio
   Bergmann, Anke
TI Electrocortical Analysis of Patients with Intercostobrachial Pain Treated with 
SO Journal of physical therapy science
LA English
DT Journal Article
DE Electroencephalography; Mastectomy; Transcutaneous electric nerve stimulation
AB [Purpose] Among the physical therapeutic procedures to decrease pain, there is 
   transcutaneous electrical neural stimulation (TENS). There is no consensus about 
   its efficacy for oncological patients, especially for post-mastectomy pain and 
   eletrocortical changes in somatosensory areas. The aim of this study was to 
   analyze acute electrocortical changes after TENS treatment of patients with 
   intercostobrachial post mastectomy pain. [Subjects] Eighteen patients were 
   divided into acupuncture (A) and burst (B) group. [Methods] In this pre and 
   post-intervention study each group was measured for EEG analysis in absulte power 
   in alpha band (8-14 Hz). Outcomes variables were the alpha waveband in the 
   sensorymotor cortex and pain pre-and-post TENS intervention. Data were analyzed 
   using ANOVA to compare times (rest, 10 and 15 min), group and electrodes. Pain 
   was analyzed using percentual pain evaluation (PPE) in both groups. [Results] 
   Outcomes indicate main effects of time and electrodes because of slow (8-10 Hz) 
   and fast alpha (10-12 Hz) wavebands decreased. PPE reduced 88.4% in A and 66.3% 
   in G. [Conclusion] TENS promoted electrical modification in the parietal region 
   and a decrease in pain. Future studies should investigate other wave must be 
   proposed for other bands and use different methods of EEG analysis to elucidate 
   the actual mechanisms behind the efficacy of TENS treatment.
C1 Department of Physical Therapy, Federal University of Rio de Janeiro (UFRJ), Brazil 
   Rehabilitation Science Masters Program, Augusto Motta University Center(UNISUAM), Brazil.
   Rehabilitation Science Masters Program, Augusto Motta University Center (UNISUAM), Brazil.
   Municipal Rehabilitation Center (CMR), Department of Physical Therapy in Oncology, Brazil.
   Department of Physical Therapy, Federal University of Rio de Janeiro (UFRJ), Brazil.
   Panic and Respiration Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro (UFRJ), Brazil 
   Quiropraxia Program, Central University, Chile.
   Rehabilitation Science Masters Program, Augusto Motta University Center (UNISUAM), Brazil 
   National Cancer Institute (INCA), Brazil.
NR 0
TC 0
SN 2187-562
EI 0915-528
J9 J Phys Ther Sci
PD APR 8
PY 2014
VL 26
IS 3
BP 349
EP 53
DI 10.1589/jpts.26.349 
PG -296
UT PubMed:24707082
PM 24707082
DA 2014-04-08
ER

PT J
AU Zhang, Q
   Zhao, Y
   Cheng, GY
AF Zhang, Qi
   Zhao, Yue
   Cheng, Guang-Yu
TI Effect of negative mood, serum inflammatory factors, miR-155, and brain-derived 
SO World journal of psychiatry
LA English
DT Journal Article
DE Abdominal surgery; Depression; Negative mood; Serum inflammatory factor; Syndrome differentiation acupuncture; Tiny RNA-155
AB BACKGROUND: Abdominal postoperative patients are susceptible to postoperative 
   depression resulting from pain and stress, which can hinder their rehabilitation. 
   Acupuncture has shown potential to relieve this condition. AIM: To analyze the 
   mechanism by which acupuncture relieves postoperative depression in patients 
   post-abdominal surgery. METHODS: Abdominal postoperative patients with depression 
   between January 2015 and December 2023 at the First Affiliated Hospital of 
   Heilongjiang University of Chinese Medicine were enrolled. Patients were divided 
   into two groups using the random throwing method: Observation (250 cases, 
   fluoxetine hydrochloride + acupuncture treatment) and control (250 cases, 
   fluoxetine hydrochloride treatment). Changes in negative emotions Hamilton 
   Depression Scale 24, serum inflammatory factors [tumor necrosis factor α, 
   interleukin (IL)-1β, IL-6], miR-155 expression levels, and BDNF levels were 
   assessed. RESULTS: Significant improvements were observed in the observation 
   group compared to the control group in all assessed parameters after six weeks (P 
   < 0.05). This suggests that the combination of fluoxetine hydrochloride and 
   acupuncture may be more effective in managing postoperative depression than 
   medication alone. CONCLUSION: Acupuncture complies with the principle of 
   traditional Chinese medicine syndrome differentiation and ensures the pertinence 
   and effectiveness of treatment. In addition, it not only actively improves 
   depressive symptoms but also effectively regulates the serum level of 
   inflammatory factors.
C1 Prevention and Treatment Center, First Affiliated Hospital Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang Province, China.
   Department of Medical, First Affiliated Hospital Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang Province, China.
   Traditional Chinese Medicine Translational Medicine Research Center, First Affiliated Hospital Heilongjiang University of Chinese Medicine, Harbin 150040,Heilongjiang Province, China. chengguangyu@hljucm.edu.cn.
NR 0
TC 0
SN 2220-320
EI 2220-320
J9 World J Psychiatry
PD FEB 20
PY 2025
VL 15
IS 2
BP 99573
EP 99573
DI 10.5498/wjp.v15.i2.99573 
PG 0
UT PubMed:39974477
PM 39974477
DA 2025-02-20
ER

PT J
AU Chou, YH
   Yeh, ML
   Huang, TS
   Hsu, H
AF Chou, Ya-Hui
   Yeh, Mei-Ling
   Huang, Tzu-Shin
   Hsu, Hedi
TI Acupoint stimulation improves pain and quality of life in head and neck cancer 
SO Asia-Pacific journal of oncology nursing
LA English
DT Journal Article
DE Acupoint stimulation; Chemoradiotherapy; Head and neck cancer; Pain; Quality of life
AB OBJECTIVE: This study aimed to evaluate the effect of acupoint stimulation on 
   pain, negative moods, and quality of life for head and neck cancer (HNC) patients 
   who underwent concurrent chemoradiotherapy (CCRT). METHODS: This randomized 
   controlled trial recruited participants from a medical center and randomly 
   assigned using a permuted block randomization list with computer-generated random 
   serial numbers into the AcuCare group (n ​= ​46) receiving acupoint stimulation 
   with transcutaneous acupoint electrical stimulation (TAES) and auricular 
   acupressure (AA) or the control group (n ​= ​46) without any acupoint 
   stimulation. Outcomes were repeatedly assessed pain intensity using the visual 
   analogue scale, negative moods using the hospital anxiety and depression scale, 
   and quality of life (QoL) using the European Organization for Research and 
   Treatment of Cancer Quality of Life Questionnaire-Head and Neck 35. RESULTS: 
   After adjusting varying mucositis grades and time-dependent growth effects, the 
   generalized estimating equations showed a significantly increase in pain 
   intensity at weeks 1, 2, 3, and 6 (P ​< ​0.05), but not in negative moods 
   (P ​> ​0.05), compared to baseline and control group. Analysis of covariance 
   showed a significant group-difference in the senses problems of QoL (F ​= ​7.33, 
   P ​= ​0.01) at Week 6. CONCLUSIONS: This study supports that acupoint stimulation 
   could effectively reduce pain and improve senses problem of QoL for patients with 
   HNC. TRIAL REGISTRATION: This study was registered at 
   https://clinicaltrials.gov/NCT03640195.
C1 Department of Nursing, Taoyuan Chang Gung Memorial Hospital
   School of Nursing, National Taipei University of Nursing and Health Sciences, Taoyuan, Taiwan.
   School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
   Department of Nursing, Taoyuan Chang Gung Memorial Hospital, Taoyuan, Taiwan.
   School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
NR 0
TC 0
SN 2349-667
EI 2347-562
J9 Asia Pac J Oncol Nurs
PD MAY 10
PY 2022
VL 9
IS 1
BP 61
EP 68
DI 10.1016/j.apjon.2021.11.002 
PG 7
UT PubMed:35528798
PM 35528798
DA 2022-05-10
ER

PT J
AU Nikitas, J
   Yanagawa, J
   Sacks, S
   Hui, EK
   Lee, A
   Deng, J
   Abtin, F
   Suh, R
   Lee, JM
   Toste, P
   Burt, BM
   Revels, SL
   Cameron, RB
   Moghanaki, D
AF Nikitas, John
   Yanagawa, Jane
   Sacks, Sandra
   Hui, Edward K
   Lee, Alan
   Deng, Jie
   Abtin, Fereidoun
   Suh, Robert
   Lee, Jay M
   Toste, Paul
   Burt, Bryan M
   Revels, Sha'Shonda L
   Cameron, Robert B
   Moghanaki, Drew
TI Pathophysiology and Management of Chest Wall Pain after Surgical and Non-Surgical 
SO JTO clinical and research reports
LA English
DT Review
DE Chest wall pain; Image guided thermal ablation; Lung cancer; Lung surgery; Radiation therapy; Thoracotomy
AB Chest wall pain syndromes can emerge following local therapies for lung cancer 
   and can adversely affect patients' quality-of-life. This can occur after lung 
   surgery, radiation therapy, or percutaneous image-guided thermal ablation. This 
   review describes the multifactorial pathophysiology of chest wall pain syndromes 
   that develop following surgical and non-surgical local therapies for lung cancer 
   and summarizes evidence-based management strategies for inflammatory, 
   neuropathic, myofascial, and osseous pain. It discusses a step-wise approach to 
   treating chest wall pain that begins with non-opioid oral analgesics and includes 
   additional pharmacologic treatments as clinically indicated, such as 
   anticonvulsants, serotonin and norepinephrine reuptake inhibitors, tricyclic 
   antidepressants, and various topical treatments. For myofascial pain, physical 
   medicine techniques, such as acupuncture, trigger point injections, deep tissue 
   massage, and intercostal myofascial release can also offer pain relief. For 
   severe or refractory cases, opioid analgesics, intercostal nerve blocks, or 
   intercostal nerve ablations may be indicated. Fortunately, palliation of 
   treatment-related chest wall pain syndromes can be managed by most clinical 
   providers, regardless of the type of local therapy utilized for a patient's lung 
   cancer treatment. In cases where a patient's pain fails to respond to initial 
   medical management, clinicians can consider referring to a pain specialist who 
   can tailor a more specific pharmacologic approach or perform a procedural 
   intervention to relieve pain.
C1 Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, California.
   Division of Thoracic Surgery, University of California, Los Angeles, Los Angeles, California.
   Department of Anesthesiology, University of California, Los Angeles, Los Angeles, California.
   Center for East-West Medicine, University of California, Los Angeles, Los Angeles, California.
   Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, California.
   Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, California.
   Thoracic Imaging and Intervention, Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, California.
   Thoracic Imaging and Intervention, Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, California.
   Division of Thoracic Surgery, University of California, Los Angeles, Los Angeles, California.
   Division of Thoracic Surgery, University of California, Los Angeles, Los Angeles, California.
   Division of Thoracic Surgery, University of California, Los Angeles, Los Angeles, California.
   Division of Thoracic Surgery, University of California, Los Angeles, Los Angeles, California.
   Division of Thoracic Surgery, University of California, Los Angeles, Los Angeles, California.
   Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, California.
   Radiation Oncology Service, Greater Los Angeles Veterans Affairs Healthcare 
NR 0
TC 0
SN 2666-364
EI 
J9 JTO Clin Res Rep
PD JUL 30
PY 2024
VL 5
IS 7
BP 100690
EP 100690
DI 10.1016/j.jtocrr.2024.100690 
PG 0
UT PubMed:39077624
PM 39077624
DA 2024-07-30
ER

PT J
AU Chen, LS
   Li, YY
   Chen, H
   Liu, BW
   Wang, DW
   Zhao, YH
AF Chen, Li-Shu
   Li, Yue-Ying
   Chen, Hao
   Liu, Bo-Wen
   Wang, Da-Wei
   Zhao, Yong-Hua
TI Polyglycolic acid sutures embedded in abdominal acupoints for treatment of simple 
SO Chinese medicine
LA English
DT Journal Article
DE Polyglycolic acid sutures embedding therapy; Regulation of inflammatory response; Simple obesity; Therapeutic effects
AB BACKGROUND: Acupoint catgut embedding therapy characterized by acupoint, needle 
   and catgut are superior to traditional acupuncture, due to exerting more 
   comprehensive therapeutic efficacy. However, it is still deficient in clinical 
   evidence for polyglycolic acid sutures, a novel biodegradable material instead of 
   catgut, embedded for the treatment of simple obesity. In our study, we 
   investigate the efficacy and related mechanism of polyglycolic acid sutures 
   embedded in abdominal acupoints on simple obese persons by a randomized control 
   trial. METHODS: A total of 51 eligible participators were randomly allocated to a 
   polyglycolic acid sutures embedding therapy (PASET) group (n = 28) or control 
   group (n = 23). Participators in PASET group received polyglycolic acid sutures 
   alternatively embedded in abdominal I group and II group acupoints in odd and 
   even number therapeutic courses, and participators in control group were required 
   to perform lifestyle modification. The duration of the study was 10 weeks. 
   RESULTS: It suggested that PASET significantly reduced weight, body mass index, 
   hip circumference, waist circumference, waist/hip ratio, waist-to-height ratio 
   and thickness of abdominal subcutaneous fat tissue compared with those before 
   treatment (p < 0.01), but lifestyle modification only illustrated downward trend 
   of weight (p < 0.05). Moreover, PASET group also improved the evaluated scores in 
   aspects of physical function, self-esteem, public distress and sexual life, as 
   well as decreased blood pressure, glycemia, low density lipoprotein, uric acid 
   and the levels of tumor necrosis factor-alpha, interleukin-1β, and increased high 
   density lipoprotein in comparison with those before treatment (p < 0.05), whose 
   efficacies are superior to control group. Additionally, our results also indicate 
   PASET is relative safe and its pain and discomfort can be tolerable. CONCLUSIONS: 
   PASET distinctly ameliorates anthropometric data and quality of life in obese 
   population, which associates with improvements of metabolic profile and 
   inflammatory response. Based on the advantageous actions, we think PASET is an 
   effective therapeutic approach to simple obesity treatment.Trial registration 
   ChiCTR, ChiCTR1800015591. Registered 10 April 2018, 
   http://www.chictr.org.cn/showproj.aspx?proj=23258.
C1 1Ningbo College of Health Sciences, Ningbo, 315100 China. ISNI: 0000 0004 1760 1080. GRID: grid.496809.a
   Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin'sClinical Research Center for Cancer, Tianjin, 300060 China.
   3Nanjing University of Chinese Medicine, Nanjing, 210046 China. ISNI: 0000 0004 1765 1045. GRID: grid.410745.3
   4Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine,Nanjing, 210008 China. ISNI: 0000 0004 1765 1045. GRID: grid.410745.3
   Shunde Hospital of Guangzhou University of Chinese Medicine, Shunde, 528333 China.
   State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, 999078 Macao SARChina.
NR 0
TC 0
SN 1749-854
EI 1749-854
J9 Chin Med
PD SEP 25
PY 2019
VL 14
IS 
BP 32
EP 32
DI 10.1186/s13020-019-0258-5 
PG 0
UT PubMed:31548850
PM 31548850
DA 2019-09-25
ER

PT J
AU Trevisani, L
   Zelante, A
   Sartori, S
AF Trevisani, Lucio
   Zelante, Angelo
   Sartori, Sergio
TI Colonoscopy, pain and fears: Is it an indissoluble trinomial?
SO World journal of gastrointestinal endoscopy
LA English
DT Review
DE Anxiety; Colonoscopy; Conscious sedation; Discomfort; Fear; Pain
AB Colonoscopy is the reference method in the secondary prevention, diagnosis and, 
   in some cases, treatment of colorectal cancer. It can often cause pain associated 
   with embarrassment, anxiety, and physical and emotional discomfort. Pain 
   intensity is influenced by a lot of factors, and there is a strict relationship 
   among pain, pain perception, and mind. Several methods can be used to break the 
   trinomial colonoscopy, pain and fear. Sedoanalgesia is recommended by several 
   guidelines. If no sedation is offered, the patient must accept a higher chance of 
   unacceptable discomfort and the endoscopist a lower chance of completing the 
   procedure because of patient discomfort. Other non-pharmacologic methods such as 
   acupuncture, music, and hydrocolonoscopy can be used as alternatives to 
   pharmacologic sedoanalgesia. Furthermore, new endoscopic technologies such as 
   variable-stiffness colonoscopes and ultrathin colonoscopes, or the use of carbon 
   dioxide instead of air for colon insufflation, can reduce the pain caused by 
   colonoscopy. In the future, technical improvements such as wireless capsules or 
   robotic probes, will probably enable to overcome the present concept of 
   colonoscopy, avoiding the use of traditional endoscopes. However, at present the 
   poor attention paid by endoscopists to the pain and discomfort caused by 
   colonoscopy can not be justified. There are several methods to reduce pain and 
   anxiety and to break the trinomial colonoscopy, pain and fear. We must use them.
C1 Lucio Trevisani, Angelo Zelante, Sergio Sartori, Digestive Endoscopy Unit, Department of Medicine, University Hospital "S. Anna", 44124 Cona (FE), Italy.
   Lucio Trevisani, Angelo Zelante, Sergio Sartori, Digestive Endoscopy Unit, Department of Medicine, University Hospital "S. Anna", 44124 Cona (FE), Italy.
   Lucio Trevisani, Angelo Zelante, Sergio Sartori, Digestive Endoscopy Unit, Department of Medicine, University Hospital "S. Anna", 44124 Cona (FE), Italy.
NR 0
TC 0
SN 1948-519
EI 1948-519
J9 World J Gastrointest Endosc
PD JUN 17
PY 2014
VL 6
IS 6
BP 227
EP 33
DI 10.4253/wjge.v6.i6.227 
PG -194
UT PubMed:24932374
PM 24932374
DA 2014-06-17
ER

PT J
AU Yan, J
   Jiang, S
   Ma, J
   Zhou, X
   Zhao, M
   Huang, J
   Zhu, H
   Huang, B
   Li, E
   Chang, H
AF Yan, Jun
   Jiang, Suying
   Ma, Junjie
   Zhou, Xuan
   Zhao, Mei
   Huang, Jinliang
   Zhu, Huimeng
   Huang, Bingyao
   Li, Ermei
   Chang, Hong
TI Use of the improved tug-of-war acupuncture for promoting cartilage repair by 
SO Heliyon
LA English
DT Journal Article
DE Knee osteoarthritis; Macrophage polarization; Tug of war acupuncture
AB INTRODUCTION: Knee osteoarthritis (KOA) is a type of joint disease causing 
   degenerative changes that are challenging to treat. The improved tug-of-war 
   acupuncture (BHZF) can improve joint pain in KOA. However, the associated 
   mechanism has not been validated. METHODS: The KOA rabbit model was established. 
   After the surgery, the improved BHZF was provided as an intervention, and the 
   animals were euthanized after 2 weeks. Histopathological changes in the synovium 
   and cartilage were observed on hematoxylin & eosin staining and Safranin O-Fast 
   Green staining. Synovial fluid and serum samples were collected to assess the 
   presence of cytokines using the enzyme-linked immunosorbent assay. The expression 
   of M1 macrophage (CD86) and M2 macrophage (ARG1) markers in the cartilage and 
   synovium was detected via immunohistochemistry and immunofluorescence assays. 
   RESULTS: The improved BHZF could reduce KOA-related pain and inhibit joint 
   swelling. Further, it significantly maintained the morphology of articular 
   chondrocytes in KOA and reduced the decomposition of the cartilage matrix. Then, 
   it significantly reduced the expression of CD86-positive cells (P < 0.05), and 
   increased the expression of ARG1-positive cells in the cartilage and synovium 
   (P < 0.05). Moreover, it significantly decreased the expression of inflammatory 
   factors interleukin (IL)-1 beta and tumor necrosis factor-alpha in the serum and 
   synovial fluid (P < 0.05), and significantly increased the expression levels of 
   anti-inflammatory cytokines IL-4 and IL-10 (P < 0.05). CONCLUSIONS: The improved 
   BHZF can relieve pain and improve cartilage damage by regulating macrophage 
   polarization in KOA.
C1 Department of Rehabilitation, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, Guangdong, China.
   Hospital Infection Control Section, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, Guangdong, China.
   Department of Rehabilitation, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, Guangdong, China.
   Department of Rehabilitation, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, Guangdong, China.
   Department of Rehabilitation, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, Guangdong, China.
   Department of Rehabilitation, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, Guangdong, China.
   Department of Rehabilitation, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, Guangdong, China.
   Department of Rehabilitation, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, Guangdong, China.
   Department of Rehabilitation, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, Guangdong, China.
   Department of Orthopedics, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510000, Guangdong, China.
NR 0
TC 0
SN 2405-844
EI 2405-844
J9 Heliyon
PD FEB 22
PY 2024
VL 10
IS 4
BP e25495
EP e25495
DI 10.1016/j.heliyon.2024.e25495 
PG 1
UT PubMed:38384563
PM 38384563
DA 2024-02-22
ER

PT J
AU Giambrone, G
   Catone, G
   Marino, G
   Sfacteria, A
   Miloro, R
   Vullo, C
AF Giambrone, Giada
   Catone, Giuseppe
   Marino, Gabriele
   Sfacteria, Alessandra
   Miloro, Renato
   Vullo, Cecilia
TI Perioperative Pain Management for Mastectomy in Dogs: A Narrative Review.
SO Animals : an open access journal from MDPI
LA English
DT Review
DE dog; mastectomy; pain management
AB Mammary tumours are the most common neoplasia in adult female dogs. Mastectomy 
   leads to moderate to severe pain. Effective pain management is crucial in 
   veterinary medicine. This review outlines analgesic techniques for managing 
   perioperative pain in dogs undergoing mastectomy. A literature search on dog 
   mastectomy analgesia was conducted from January 2001 to January 2025. Pre-emptive 
   meloxicam reduces postoperative cardiovascular changes without affecting renal 
   function. When combined with gabapentin, it lowers the need for rescue analgesic 
   opioids, similar to robenacoxib. With regard to tramadol, it offers contrasting 
   analgesia in the studies considered when used alone, while its effect appears 
   enhanced when used in combination with meloxicam/dipyrone. However, methadone 
   provides superior pain control, especially when given preoperatively or 
   intraoperatively. The combination of ketamine, lidocaine, and maropitant enhances 
   pain management, while fentanyl, alone or with lidocaine and ketamine, is 
   effective for intraoperative pain control. Local infiltration with 
   lidocaine/bupivacaine provides effective pain control, and devices like 
   Comfont-in(®) or WSC facilitate this process. Tumescent anaesthesia using 
   lidocaine/ropivacaine allows for extensive infiltration of the mammary gland. 
   Epidural analgesia, paravertebral blocks, and TAP blocks are beneficial in 
   multimodal protocols. Transdermal patches containing fentanyl/buprenorphine offer 
   prolonged analgesia, while electroacupuncture can help reduce the need for rescue 
   analgesics. Multimodal analgesic protocols are crucial for effective pain 
   management in dog mastectomy surgeries, minimising the need for rescue opioids.
C1 Department of Veterinary Sciences, University of Messina, Via G. Palatucci, 98168 Messina, Italy.
   Department of Veterinary Sciences, University of Messina, Via G. Palatucci, 98168 Messina, Italy.
   Department of Veterinary Sciences, University of Messina, Via G. Palatucci, 98168 Messina, Italy.
   Department of Veterinary Sciences, University of Messina, Via G. Palatucci, 98168 Messina, Italy.
   Department of Veterinary Sciences, University of Messina, Via G. Palatucci, 98168 Messina, Italy.
   Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina,Italy.
NR 0
TC 0
SN 2076-261
EI 2076-261
J9 Animals (Basel)
PD MAY 14
PY 2025
VL 15
IS 9
BP 
EP 
DI 10.3390/ani15091214 
PG 0
UT PubMed:40362030
PM 40362030
DA 2025-05-14
ER

PT J
AU Zhou, M
   Pang, F
   Liao, D
   He, X
   Yang, Y
   Tang, C
AF Zhou, Min
   Pang, Fang
   Liao, Dongmei
   He, Xinlu
   Yang, Yunhao
   Tang, Chenglin
TI Electroacupuncture at Fengchi(GB20) and Yanglingquan(GB34) Ameliorates Paralgesia 
SO Brain sciences
LA English
DT Journal Article
DE electroacupuncture; inflammatory response; microglia; migraine; paralgesia
AB BACKGROUND: Multiple studies have suggested that paralgesia (hyperalgesia and 
   cutaneous allodynia) in migraine reflects the activation and sensitisation of the 
   trigeminovascular system (TGVS). In particular, it reflects the second-order and 
   higher nerve centre sensitisation, which is caused and maintained by 
   neuroinflammation. Microglia activation leads to the release of proinflammatory 
   cytokines involved in inflammatory responses. Accumulating evidence indicates 
   that electroacupuncture (EA) is effective in ameliorating paralgesia, but the 
   underlying mechanisms of EA in migraine attacks caused by microglia and 
   microglia-mediated inflammatory responses are still unclear. The purpose of this 
   study was to explore whether EA could ameliorate the dysregulation of pain 
   sensation by suppressing microglial activation and the resulting 
   neuroinflammatory response, and to evaluate whether this response was regulated 
   by Toll-like receptor 4 (TLR4)/nuclear factor-kappa B(NF-κB) in the trigeminal 
   nucleus caudalis (TNC) in a rat model of migraine. METHODS: Repeated Inflammatory 
   Soup (IS) was infused into the dura for seven sessions to establish a recurrent 
   migraine-like rat model, and EA treatment was administered at Fengchi (GB20) and 
   Yanglingquan (GB34) after daily IS infusion. Facial mechanical withdrawal 
   thresholds were measured to evaluate the change in pain perception, and plasma 
   samples and the TNC tissues of rats were collected to examine the changes in 
   calcitonin gene-related peptide (CGRP), the Ibal-1-labelled microglial 
   activation, and the resulting inflammatory response, including interleukin-1β 
   (IL-1β), tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), and their 
   regulatory molecules TLR4/NF-κB, via enzyme-linked immunosorbent assay (ELISA), 
   real-time polymerase chain reaction (RT-PCR), immunohistochemistry (IHC) and 
   Western blot analysis. RESULTS: Repeated IS injections into the dura induced 
   facial mechanical paralgesia, which is the manifestation of migraine attacks, and 
   increased the expression of CGRP, Ibal-1, microglial mediated inflammatory 
   cytokines (IL-1β, TNF-α, IL-6), and regulatory molecules TLR4/NF-κB. EA at 
   GB20/34 significantly attenuated repetitive IS-induced pain hypersensitivity. 
   This effect was consistent with decreased levels of CGRP and inflammatory 
   cytokines in the plasma and the TNC via the inhibition of microglia activation, 
   and this response may be regulated by TLR4/NF-κB. CONCLUSIONS: EA ameliorated 
   paralgesia in repetitive IS-induced migraine-like rats, which was mainly mediated 
   by a reduction in microglial activation and microglial-mediated inflammatory 
   responses that could be regulated by TLR4/NF-κB.
C1 College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
   Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure 
   College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
   Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure 
   College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
   Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure 
   College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
   Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure 
   College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
   Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure 
   College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
   Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure 
NR 0
TC 0
SN 2076-342
EI 2076-342
J9 Brain Sci
PD MAY 16
PY 2023
VL 13
IS 4
BP 
EP 
DI 10.3390/brainsci13040541 
PG 0
UT PubMed:37190506
PM 37190506
DA 2023-05-16
ER

PT J
AU Zhou, J
   Jin, Y
   Ma, R
   Song, H
   Chen, Q
   Chai, Y
   Liang, Y
   Zhou, Y
   Fang, J
AF Zhou, Jie
   Jin, Ying
   Ma, Ruijie
   Song, Hongyun
   Chen, Qin
   Chai, Yueyang
   Liang, Yi
   Zhou, You
   Fang, Jianqiao
TI Electroacupuncture Alleviates Experimental Chronic Inflammatory Pain by 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB BACKGROUND: Both experimental and clinical studies have shown that 
   electroacupuncture (EA) administration ameliorates chronic inflammatory pain 
   (CIP). However, the multifaceted mechanism underlying the effects of EA on CIP is 
   poorly understood. In this study, the mRNA transcriptome was used to study 
   various therapeutic targets of EA. METHODS: Using RNA-sequencing, protein-coding 
   mRNA expression profiles of the L4-L5 dorsal root ganglion (DRG) were examined in 
   the control (CN), complete Freund's adjuvant- (CFA-) induced CIP, and EA-treated 
   CIP groups. A series of bioinformatics analyses was performed; "EA-reversed 
   upregulated genes with CIP" (up-DEGs) and "EA-reversed downregulated genes with 
   CIP" (down-DEGs) were identified. Thereafter, based on up-DEGs and down-DEGs, 
   biological functions and signaling pathways were enriched using gene ontology 
   (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway analyses. 
   RESULTS: In total, 189 DEGs were identified, including 134 up- and 55 down-DEGs, 
   which were enriched in arachidonic acid metabolism (rno00590), glutamatergic 
   synapse (rno04724), serotonergic synapse (rno04726), FoxO signaling pathway 
   (rno04068), insulin signaling pathway (rno04910), amyotrophic lateral sclerosis 
   (rno05014), cholinergic synapse (rno04725), ECM-receptor interaction (rno04512), 
   and choline metabolism in cancer (rno05231). CONCLUSION: We identified a few GOs, 
   pathways, and genes that could play key roles in the amelioration of CIP by EA. 
   Hence, this study may provide a theoretical basis for CIP amelioration by EA.
C1 The Third Affiliated Hospital of Zhejiang Chinese Medical University, 219 Moganshan Road, Xihu District, Hangzhou City, Zhejiang Province 310005, China.
   Department of Rehabilitation in Traditional Chinese Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88, JiefangRd,Hangzhou City, Zhejiang Province 310000, China.
   The Third Affiliated Hospital of Zhejiang Chinese Medical University, 219 Moganshan Road, Xihu District, Hangzhou City, Zhejiang Province 310005, China.
   Department of Rehabilitation in Traditional Chinese Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88, JiefangRd,Hangzhou City, Zhejiang Province 310000, China.
   The Third Affiliated Hospital of Zhejiang Chinese Medical University, 219 Moganshan Road, Xihu District, Hangzhou City, Zhejiang Province 310005, China.
   Department of Emergency Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88, JiefangRd, Hangzhou City, ZhejiangProvince 310000, China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou City, Zhejiang Province 310053, China.
   Department of Rehabilitation in Traditional Chinese Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88, JiefangRd,Hangzhou City, Zhejiang Province 310000, China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou 310053,China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD FEB 28
PY 2020
VL 2020
IS 
BP 7061972
EP 7061972
DI 10.1155/2020/7061972 
PG 0
UT PubMed:32104194
PM 32104194
DA 2020-02-28
ER

PT J
AU Li, F
   Wan, H
   Liu, X
   Deng, Y
   Tian, W
   Zhao, Z
AF Li, Fanrui
   Wan, Hejia
   Liu, Xiaohui
   Deng, Yuanting
   Tian, Wuyang
   Zhao, Zilin
TI Auricular Acupoint Therapy in Symptom Management of Cancer patients: A Scoping 
SO Cancer management and research
LA English
DT Review
DE auricular point therapy; cancer; scoping review; symptom management
AB BACKGROUND: The incidence of cancer is rising annually. With advances in 
   diagnosis and treatment, cancer patients' long-term survival rates have improved, 
   leading them to gradually enter a chronic disease state. However, they frequently 
   experience physiological and psychological symptoms during treatment, which 
   severely impact their survival and quality of life. Auricular acupoint therapy, a 
   green non-pharmacological intervention characterized by ease of operation and low 
   cost, can alleviate cancer-related symptoms. Despite its widespread use, 
   systematic summarization and comprehensive evaluation of this therapy remain 
   insufficient. OBJECTIVE: To systematically analyze the application of auricular 
   therapy in cancer patients, identify its characteristics and intervention effects 
   on symptoms, and provide a reference for symptom management in these patients. 
   METHODS: Relevant studies were systematically retrieved from PubMed, Web of 
   Science, Cochrane Library, Embase, CINAHL, CNKI, CBM, WanFang Database, and VIP 
   Database from their inception to April 20, 2025. Data from the included 
   literature were extracted and analyzed. RESULTS: A total of 42 studies were 
   included. Auricular therapy is applicable across multiple stages of cancer care 
   and exerts positive effects on cancer-related pain, fatigue, sleep disorders, 
   anxiety, and chemotherapy-induced symptoms. Notably, the pain-fatigue-sleep 
   disorder cluster is the most common and interrelated symptom group, with 
   auricular acupressure as the most frequently used intervention. CONCLUSION: Owing 
   to its simplicity and cost-effectiveness, auricular therapy offers unique 
   advantages for managing symptoms in cancer patients. The current focus in this 
   field has shifted from managing single symptoms or individual dimensions within 
   symptom clusters to a comprehensive management of symptom clusters. Future 
   research should pay attention to the dynamic progression of symptoms, focus on 
   the core symptom clusters in cancer patients, and optimize intervention 
   strategies to enhance the efficiency of symptom management.
C1 School of Nursing (Nursing School of Smart Healthcare Industry), Henan University of Chinese Medicine, Zhengzhou, Henan, People's Republic of China.
   School of Nursing (Nursing School of Smart Healthcare Industry), Henan University of Chinese Medicine, Zhengzhou, Henan, People's Republic of China.
   School of Nursing (Nursing School of Smart Healthcare Industry), Henan University of Chinese Medicine, Zhengzhou, Henan, People's Republic of China.
   Nursing Department, Henan Provincial Hospital of Traditional Chinese Medicine 
   School of Nursing (Nursing School of Smart Healthcare Industry), Henan University of Chinese Medicine, Zhengzhou, Henan, People's Republic of China.
   School of Nursing (Nursing School of Smart Healthcare Industry), Henan University of Chinese Medicine, Zhengzhou, Henan, People's Republic of China.
   School of Nursing (Nursing School of Smart Healthcare Industry), Henan University of Chinese Medicine, Zhengzhou, Henan, People's Republic of China.
NR 0
TC 0
SN 1179-132
EI 1179-132
J9 Cancer Manag Res
PD DEC 9
PY 2025
VL 17
IS 
BP 3005
EP 3023
DI 10.2147/CMAR.S562388 
PG 18
UT PubMed:41362632
PM 41362632
DA 2025-12-09
ER

PT J
AU Zhou, X
   Cao, SG
   Tan, XJ
   Liu, XD
   Li, ZQ
   Kong, LX
   Tian, YL
   Liu, D
   Shen, S
   Sun, YQ
   Jiang, HT
   Zhou, YB
AF Zhou, Xin
   Cao, Shou-Gen
   Tan, Xiao-Jie
   Liu, Xiao-Dong
   Li, Ze-Qun
   Kong, Ling-Xin
   Tian, Yu-Long
   Liu, Dan
   Shen, Shuai
   Sun, Yu-Qi
   Jiang, Hai-Tao
   Zhou, Yan-Bing
TI Effects of Transcutaneous Electrical Acupoint Stimulation (TEAS) on Postoperative 
SO Cancer management and research
LA English
DT Journal Article
DE acupuncture therapy; enhanced recovery after surgery; gastrointestinal function; pain management; stomach neoplasms
AB PURPOSE: Transcutaneous electrical acupoint stimulation (TEAS) is an innovative 
   choice for postoperative pain management. However, the safety and effectiveness 
   of this traditional Chinese medicine (TCM) therapy for patients who underwent 
   gastrectomy is largely unknown. So, the purpose of this study is to evaluate the 
   safety and effectiveness of TEAS for patients who underwent gastrectomy. PATIENTS 
   AND METHODS: We recruited 96 patients with gastric cancer from May 2019 to 
   November 2019; 82 patients were enrolled, and 81 patients completed. Patients 
   were randomly assigned to TEAS group (TG) received TEAS on postoperative day 
   (POD) 1-3 or control group (CG) at a 1:1 ratio. The primary outcomes were pain 
   score and consumption of analgesics. The secondary were the time of first 
   postoperative flatus and defecation, frequency of postoperative nausea, vomiting, 
   distention, diarrhea, comfort of semi-fluid diet, Clavien-Dindo grade (C-D grade) 
   and length of postoperative day. We performed hematological analysis to explore 
   the possible mechanisms. RESULTS: Overall, 81 patients were enrolled included in 
   the analysis. Compared with CG, pain scores in TG were lower on POD 1-5 (average: 
   2.55±0.21 vs 3.10±0.42, P<0.001), and the use rate of opioids was lower (43.9 vs 
   75.0, P=0.004); time of first postoperative flatus (55.63±16.74 vs 72.60±20.92, 
   P<0.001) and defecation (72.20±16.24 vs 95.78±17.75, P<0.001) were shorter; the 
   frequency of nausea were fewer (1.88±1.09 vs 2.58±0.77, P=0.029) and patients 
   were more comfortable with semi-fluid diet (7.63±0.63 vs 6.93±0.69, P<0.001); 
   among the hematologic results, β-endorphin (β-End), interleukin-2 (IL-2), motilin 
   (MTL) on POD 3, POD 5 were lower, 5-hydroxytryptamine (5-HT), interleukin-6 
   (IL-6), tumor necrosis factor-α (TNF-α) were higher. And no adverse event was 
   reported. CONCLUSION: TEAS can relieve postoperative pain and promote the 
   recovery of gastrointestinal function. Consequently, it can be an adjunctive 
   therapy to enhance postoperative recovery for patients after gastrectomy.
C1 Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
   Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
   Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
   Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
   Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
   Department of Rehabilitation, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
   Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
   Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
   Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
   Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
   Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
   Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
NR 0
TC 0
SN 1179-132
EI 1179-132
J9 Cancer Manag Res
PD FEB 20
PY 2021
VL 13
IS 
BP 1449
EP 1458
DI 10.2147/CMAR.S292325 
PG 9
UT PubMed:33603487
PM 33603487
DA 2021-02-20
ER

PT J
AU Yin, J
   Feng, M
   Xu, H
AF Yin, Jie
   Feng, Mengmeng
   Xu, Haiyang
TI Cai's gynecology chronic pelvic formula with acupuncture alleviates chronic 
SO American journal of translational research
LA English
DT Journal Article
DE Cai’s gynecology chronic pelvic formula; acupuncture; chronic pelvic pain; clinical efficacy; cox regression analysis; recurrence rate
AB OBJECTIVE: To assess the efficacy of Cai's Gynecology Chronic Pelvic Formula 
   combined with acupuncture in managing chronic pelvic pain (CPP) secondary to 
   pelvic inflammatory disease (PID) sequelae, and its effect on recurrence. 
   METHODS: A retrospective study assessed medical records from 240 CPP patients 
   undergoing treatment between February 2019 and February 2024. Patients were 
   divided into a control group (standard treatment, n = 120) and an observation 
   group (standard treatment plus Cai's Chronic Pelvic Formula combined with 
   acupuncture, n = 120), with treatment lasted for 28 days and follow-up for 6 
   months. The symptom scores (Visual Analog Scale, Self-rating Anxiety Scale and 
   Self-rating Depression Scale), inflammatory markers [C-reactive protein (CRP), 
   tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and cancer antigen 125 
   (CA125)], efficacy rates, and recurrence rates were all employed to measure 
   treatment outcomes. Cox regression was leveraged to identify recurrence risk 
   factors, while a nomogram model was developed and validated by Receiver Operating 
   Characteristic (ROC), calibration curves, and decision curve analysis (DCA). 
   RESULTS: The observation group had significantly lower post-treatment Traditional 
   Chinese Medicine symptom scores, inflammatory markers (CRP: P < 0.001; TNF-α: P = 
   0.003; IL-6: P = 0.004), and CA125 (P < 0.001) versus the control group. The 
   observation group also demonstrated shorter symptom resolution time (P < 0.05), 
   with higher total treatment efficacy in comparison to the control group (93.46% 
   vs. 79.70%; P = 0.002). In addition, the observation group showed lower 
   recurrence rates (14.2% vs. 28.3%; P = 0.008) as well as postponed recurrence 
   time when compared to the control group. Cox regression analysis identified 
   treatment protocol (HR = 0.41, 95% CI: 0.24-0.71), disease duration (HR = 1.32, 
   95% CI: 1.08-1.62), and pre-treatment CRP level (HR = 1.18, 95% CI: 1.02-1.36) as 
   independent recurrence predictors. In addition, the nomogram demonstrated high 
   accuracy in predicting disease recurrence (C-index = 0.852), with both ROC (AUC = 
   0.837) and calibration curves confirming its reliability. DCA indicated high 
   clinical net benefit of the studying treatment protocol. CONCLUSION: Cai's 
   Gynecology Chronic Pelvic Formula combined with acupuncture could significantly 
   alleviate CPP and inflammation, and decrease recurrence rates. The nomogram may 
   be used as a validated tool for predicting the disease recurrence, with benefits 
   when integrated into clinical practice as a novel therapeutic strategy.
C1 Department of Gynaecology, Shangluo Traditional Chinese Medicine Hospital No. 148, Beixin Street, Shangzhou District, Shangluo 726000, Shaanxi, China.
   Traditional Chinese Medicine Teaching and Research Office, Shangluo Vocational and Technical College Dannan New District, West Section of Shangyang Avenue,Shangluo 726000, Shaanxi, China.
   Department of Postpartum and Pelvic Floor Rehabilitation, Xi'an International Medical Center Hospital No. 777 Xitai Road, Chang'an District, Xi'an 710100,Shaanxi, China.
NR 0
TC 0
SN 1943-814
EI 1943-814
J9 Am J Transl Res
PD AUG 18
PY 2025
VL 17
IS 7
BP 5241
EP 5256
DI 10.62347/YVFO2330 
PG 15
UT PubMed:40821053
PM 40821053
DA 2025-08-18
ER

PT J
AU Lu, C
   Li, G
   Deng, D
   Li, R
   Li, X
   Feng, X
   Wu, T
   Shao, X
   Chen, W
AF Lu, Chao
   Li, Guangliang
   Deng, Dehou
   Li, Rongrong
   Li, Xiaoyu
   Feng, Xukang
   Wu, Taoping
   Shao, Xiying
   Chen, Weiji
TI Efficacy of electroacupuncture in the treatment of peripheral neuropathy caused 
SO Frontiers in neurology
LA English
DT Journal Article
DE Utidelone (UTD1); breast cancer; chemotherapy-induced peripheral neuropathy (CIPN); electroacupuncture (EA); peripheral neuropathy (PN); protocol
AB INTRODUCTION: Utidelone (UTD1) is a new chemotherapeutic drug for recurrent or 
   metastatic breast cancer. However, it usually leads to severe peripheral 
   neuropathy (PN) and causes numbness of the hands and feet and significant pain in 
   patients' life. Electroacupuncture (EA) is considered beneficial in improving PN 
   and relieving numbness of the hands and feet. This trial aims to evaluate the 
   therapeutic effect of EA on PN caused by UTD1 in patients with advanced breast 
   cancer. METHODS AND ANALYSIS: This study is a prospective randomized controlled 
   trial. A total of 70 patients with PN caused by UTD1 will be randomly assigned to 
   the EA treatment group and the control group in a ratio of 1:1. The patients in 
   the EA treatment group will receive 2 Hz EA three times a week for 4 weeks. The 
   patients in the control group will take mecobalamin (MeCbl) tablets orally, one 
   tablet each, three times a day for 4 weeks. The main outcome measures will be the 
   evaluation scale of peripheral neurotoxicity of chemotherapeutic drugs according 
   to the European Organization for Research and Treatment of Cancer Quality of Life 
   Questionnaire-CIPN 20-item (EORTC QLQ-CIPN20) and the peripheral neurotoxicity 
   assessment rating according to NCI CTCAE version 5.0. Secondary outcomes will be 
   the quality of life scale according to the European Organization for Research and 
   Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30). The 
   results will be evaluated at baseline, post-treatment phase, and follow-up. All 
   major analyses will be based on the intention-to-treat principle. ETHICS AND 
   DISSEMINATION: This protocol was approved by the Medical Ethics Committee of 
   Zhejiang Cancer Hospital on 26 July 2022. The license number is IRB-2022-425. 
   This study will provide clinical efficacy data on EA in the treatment of PN 
   caused by UTD1 and will help to prove whether EA is an effective and safe 
   therapy. The study results will be shared with healthcare professionals through 
   the publication of manuscripts and conference reports. TRIAL REGISTRATION NUMBER: 
   ChiCTR2200062741.
C1 Department of Traditional Chinese Medicine, Zhejiang Cancer Hospital, Hangzhou, China.
   Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
   Department of Traditional Chinese Medicine, Zhejiang Cancer Hospital, Hangzhou, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province),Hangzhou, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province),Hangzhou, China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, 
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
   The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
   Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
   Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province),Hangzhou, China.
NR 0
TC 0
SN 1664-229
EI 1664-229
J9 Front Neurol
PD FEB 28
PY 2023
VL 14
IS 
BP 1065635
EP 1065635
DI 10.3389/fneur.2023.1065635 
PG 0
UT PubMed:36846114
PM 36846114
DA 2023-02-28
ER

PT J
AU Bonucci, M
   Geraci, A
   Pero, D
   Villivà, C
   Cordella, D
   Condello, M
   Meschini, S
   Del, Campo L
   Tomassi, F
   Porcu, A
   De, Lorenzo F
   Lozupone, F
AF Bonucci, Massimo
   Geraci, Andrea
   Pero, Dina
   Villivà, Cristina
   Cordella, Daniele
   Condello, Maria
   Meschini, Stefania
   Del Campo, Laura
   Tomassi, Franco
   Porcu, Alessandro
   De Lorenzo, Francesco
   Lozupone, Francesco
TI Complementary and Integrative Approaches to Cancer: A Pilot Survey of Attitudes 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB BACKGROUND: Cancer patients are among the main consumers of traditional, 
   complementary, integrative, and alternative medicine (TCIM) such as natural 
   products (herbals, integrators, etc.) and mind and body practices (yoga, 
   acupuncture, etc.). METHODS: A questionnaire on TCIM was submitted to 415 Italian 
   cancer patients. The questionnaire consisted of three sections: (i) biographical 
   and clinical information; (ii) use of natural substances; and (iii) use of 
   mind-body practices. RESULTS: 406 patients completed the questionnaire. The 
   prevalence of TCIM use was 72.3%. Of them, 75.6% started to use TCIM after a 
   tumor diagnosis. The main reasons for using TCIM were to mitigate side effects 
   (65.0%), to regain physical and mental balance (35.9%), to relieve pain (18.3%), 
   and to improve the efficacy of cancer therapy (16.0%). 44.7% of patients taking 
   natural products used them during conventional therapies (chemotherapy, 
   radiotherapy, etc.), and in 67.5% of cases without consulting a doctor. As a 
   consequence, only about 50% of patients taking natural substances used these 
   compounds appropriately, and the most common errors were related with the purpose 
   of reducing the side effects of the therapy (52.3%) and for boosting immune 
   system (32.1%). CONCLUSIONS: There is an impelling need to provide patients with 
   scientifically validated information to raise awareness about the benefits and 
   risks of using TCIM.
C1 Association for Research on Integrative Oncological Therapies (ARTOI), Roma, Italy.
   Italian Center for Global Health, Istituto Superiore di Sanità, Roma, Italy.
   Italian Association for Cancer Patients, Relatives and Friends (AIMaC), Roma, Italy.
   Association for Research on Integrative Oncological Therapies (ARTOI), Roma, Italy.
   Directorate-General Information Technology Unit, Istituto Superiore di Sanità, Roma, Italy.
   National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Roma, Italy.
   National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Roma, Italy.
   Italian Association for Cancer Patients, Relatives and Friends (AIMaC), Roma, Italy.
   Association for Research on Integrative Oncological Therapies (ARTOI), Roma, Italy.
   Italian Association for Cancer Patients, Relatives and Friends (AIMaC), Roma, Italy.
   Italian Association for Cancer Patients, Relatives and Friends (AIMaC), Roma, Italy.
   Italian Center for Global Health, Istituto Superiore di Sanità, Roma, Italy.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD AUG 13
PY 2022
VL 2022
IS 
BP 2923967
EP 2923967
DI 10.1155/2022/2923967 
PG 0
UT PubMed:35958921
PM 35958921
DA 2022-08-13
ER

PT J
AU Radeva, S
   Zaralieva, A
   Tonev, D
AF Radeva, Stoika
   Zaralieva, Aycha
   Tonev, Dimitar
TI Predetermined physical factors and alternative factors in the treatment of 
SO Reumatologia
LA English
DT Journal Article
DE chronic pain; discogenic lumbosacral radiculitis; predetermined physical factors
AB OBJECTIVES: Evolution of acute pain in discogenic lumbosacral radiculopathy to 
   subacute and chronic pain reflects pharmacotherapeutic issues and even 
   helplessness in some cases. It has social significance since 80% of people in 
   working age have faced it at least once in their working lifetime. Most of the 
   acute and subacute (> 6 weeks) episodes resolve within 3 months while in 10-15% 
   of patients their condition does not resolve and they develop chronic (> 3 
   months) lumbosacral syndrome. MATERIAL AND METHODS: We present our experience in 
   non-pharmaceutical treatment of chronic pain in discogenic lumbosacral 
   radiculopathy after comparison of different predetermined and alternative 
   therapies that have been given to patients who were selected by highly 
   informative assessment indicators for the extent of spinal root lesion. Sixty 
   patients were enrolled in this study and were divided into two groups of 30 
   patients each. The first group was treated with classic acupuncture, and the 
   second group with two predetermined factors from conventional physiotherapy. The 
   effect of the two treatments applied was followed up after each procedure in the 
   therapeutic course, and also a month later. RESULTS: As a result of the obtained 
   statistical data, we present a variant of non-invasive treatment of chronic pain 
   that would be useful in clinical practice. CONCLUSIONS: In cases of chronic pain 
   in this particular disease, a recommendation should be given for the combination 
   of two physical factors - paravertebral application of ultrasound in impulse mode 
   with an appropriate anti-inflammatory medicament as a mediator in the area of the 
   lumbosacral spine segment, by a labile method, combined with low frequency 
   impulse magnet field in the low back area and the affected leg. Also, acupuncture 
   could be used in fighting against pain, especially in patients contraindicated 
   for predetermined factors (those with a pacemaker, or an oncological process in 
   the small pelvis area).
C1 Department of Physiotherapy, Tsaritsa Yoanna-ISUL University Hospital, Sofia, Bulgaria.
   Department of Physical Medicine and Rehabilitation, Medical University Sofia, Bulgaria.
   Department of Anesthesiology and Intensive Care, Tsaritsa Yoanna-ISUL University Hospital, Sofia, Bulgaria.
NR 0
TC 0
SN 2084-983
EI 0034-623
J9 Reumatologia
PD JUL 6
PY 2022
VL 60
IS 2
BP 110
EP 115
DI 10.5114/reum.2022.116143 
PG 5
UT PubMed:35782025
PM 35782025
DA 2022-07-06
ER

PT J
AU Mazur-Bialy, A
   Tim, S
   Pępek, A
   Skotniczna, K
   Naprawa, G
AF Mazur-Bialy, Agnieszka
   Tim, Sabina
   Pępek, Anna
   Skotniczna, Kamila
   Naprawa, Gabriela
TI Holistic Approaches in Endometriosis - as an Effective Method of Supporting 
SO Reproductive sciences (Thousand Oaks, Calif.)
LA English
DT Review
DE Endometriosis; Manual therapy; Pain; Physical activity; Physiotherapy; Quality of life
AB Endometriosis is one of the gynecological diseases where women suffer from pain, 
   quality of life decreased. The aim of this review was to describe the most common 
   non-medical methods used in the treatment of symptoms associated with 
   endometriosis and to determine their effectiveness. The review was performed in 
   PubMed, Embase and Web of Science databases. Randomized controlled trials, case 
   studies, observational studies, retrospective studies, prospective studies, pilot 
   studies, trails, publications in English or Polish were searched based on the 
   Participant-Intervention-Comparator-Outcomes-Study design (PICOS) format. The 
   criteria used to select studies were: women with endometriosis, no cancer, 
   included any physiotherapeutic or non-medical intervention. 3706 articles were 
   found, however only 26 met the inclusion criteria and were included in the 
   review. Quality of the studies was assessed by Risk of Bias 2 tool and ROBINS-1 
   tool. The most holistic approach used in the treatment of symptoms of 
   endometriosis include physical therapy, manual therapy, electrophysical agents 
   acupuncture, diet and psychological interventions. Most research has focused on 
   relieving pain and increasing quality of life. Non-medical methods showed 
   reduction of symptoms of endometriosis. Physical activity, manual therapy, 
   electrophysical agents, acupuncture, diet and cognitive behavioral therapy showed 
   no negative side effects and reduced pain, what improved the quality of life and 
   reduced the perceived stress.
C1 Department of Biomechanics and Kinesiology, Faculty of Health Science, Jagiellonian University Medical College, Skawińska 8, Krakow, 31-066, Poland.agnieszka.mazur@uj.edu.pl.
   Department of Biomechanics and Kinesiology, Faculty of Health Science, Jagiellonian University Medical College, Skawińska 8, Krakow, 31-066, Poland.
   Student Scientific Group, Faculty of Health Science, Jagiellonian University Medical College, Krakow, Poland.
   Student Scientific Group, Faculty of Health Science, Jagiellonian University Medical College, Krakow, Poland.
   Student Scientific Group, Faculty of Health Science, Jagiellonian University Medical College, Krakow, Poland.
NR 0
TC 0
SN 1933-720
EI 1933-719
J9 Reprod Sci
PD JUL 24
PY 2024
VL 31
IS 11
BP 3257
EP 3274
DI 10.1007/s43032-024-01660-2 
PG 17
WC Female; Humans; Endometriosis; therapy; Holistic Health; Quality of Life; Treatment Outcome
UT PubMed:39043999
PM 39043999
DA 2024-07-24
ER

PT J
AU Caiado-Vencio, R
   Raffa, PEAZ
   Lopes, BM
   Cobucci, FLR
   Vieira, RVG
   Franceschini, PR
   de, Aguiar PHP
AF Caiado-Vencio, Rafael
   Raffa, Paulo Eduardo Albuquerque Zito
   Lopes, Bruna Marques
   Cobucci, Fernanda Lopes Rocha
   Vieira, Raphael Vinícius Gonzaga
   Franceschini, Paulo Roberto
   de Aguiar, Paulo Henrique Pires
TI Success of lateral cervical spinal cord stimulation for the treatment of chronic 
SO Surgical neurology international
LA English
DT Journal Article
DE Epidural lead; Lateral spinal cord; Neurostimulation; Schwannoma; Spinal cord stimulation
AB BACKGROUND: Spinal cord stimulation (SCS) is traditionally performed by 
   implanting surgical leads along the midline of the spinal cord, over the dorsal 
   columns. Here, we present a patient who successfully underwent lateral cervical 
   SCS to treat chronic refractory neuropathic pain. METHODS: A 46-year-old female, 
   with a schwannoma involving the right axillary nerve, presented with a chronic 
   refractory right upper extremity pain syndrome. The tumor was located between the 
   fibers of the teres minor and the posterior deltoid, and measured 2.2 cm in 
   diameter. After 8 months of analgesics, opioids, physiotherapy, and acupuncture, 
   the patient underwent surgery; however, the tumor was unresectable (i.e., due to 
   significant adjacent vascular/neural structures). Three months later, she had a 
   midline C6-C7 laminectomy for placement of a right-sided epidural SCS lead (i.e., 
   containing 16 electrode contacts). RESULTS: Within 4 days following this SCS 
   procedure, the patient's pain completely resolved; at 10 postoperative months, 
   she still remains pain free. CONCLUSION: Lateral SCS at the C6-C7 level provided 
   a safe and effective option for the relief of chronic neuropathic pain attributed 
   to an unresectable schwannoma of the right axillary nerve in a 46-year-old 
   female.
C1 Department of Medicine, Pontifical Catholic University of Goiás, Goiânia, Goiás, Brazil.
   Department of Medicine, Catanduva Medical School (FAMECAUNIFIPA), Catanduva, Brazil.
   Department of Medicine, Faculty of Medical Sciences, Santa Casa de São Paulo, Brazil.
   Department of Medicine, Faculdade de Medicina do ABC, Brazil.
   Department of Neurosurgery, Santa Paula Hospital, São Paulo, Brazil.
   Department of Neurology and Neurosurgery, University of Caxias do Sul, Rio Grande do Sul, Brazil.
   Department of Neurology, Pontifical Catholic University of São Paulo, Sao Paulo, Brazil.
NR 0
TC 0
SN 2152-780
EI 2229-509
J9 Surg Neurol Int
PD MAR 5
PY 2022
VL 13
IS 
BP 52
EP 52
DI 10.25259/SNI_853_2021 
PG 0
UT PubMed:35242418
PM 35242418
DA 2022-03-05
ER

PT J
AU Zhang, XC
   Shen, DL
   Shi, JL
   Gong, GW
   Wang, G
   Jiang, ZW
   Jin, HY
   Deng, ZM
AF Zhang, Xiao-Chun
   Shen, Dan-Li
   Shi, Jia-Ling
   Gong, Guan-Wen
   Wang, Gang
   Jiang, Zhi-Wei
   Jin, Hei-Ying
   Deng, Zheng-Ming
TI Development of a Nomogram for Predicting Postoperative Prolonged Ileus in Gastric 
SO The American surgeon
LA English
DT Journal Article
DE electroacupuncture; gastric cancer; nomogram; postoperative ileus; risk prediction
AB ObjectiveTo develop and validate a nomogram for predicting the risk of 
   postoperative prolonged ileus (PPOI) in patients undergoing gastric cancer (GC) 
   surgery, providing a personalized risk assessment tool for early identification 
   and optimized postoperative management.MethodsA retrospective cohort (January 
   2019-December 2023) was used to develop and internally test the nomogram, while a 
   prospective cohort (January-December 2024) was used for external validation. 
   Univariate and multivariate logistic regression with backward stepwise selection 
   identified independent predictors. Model performance was assessed through 
   receiver operating characteristic (ROC) curves, calibration curves, 
   decision-curve analysis (DCA), and clinical impact curve analysis (CICA). 
   Patients were stratified into low, medium, and high-risk groups based on nomogram 
   scores for further analysis.ResultsA total of 780 patients in the training cohort 
   and 294 in the validation cohort were included, with postoperative prolonged 
   ileus rates of 11.54% and 16.33%, respectively (χ(2) = 4.371, P =.037). 
   Independent predictors included electroacupuncture, pain self-efficacy 
   questionnaire (PSEQ) score, preoperative serum albumin (Alb), body fat, 
   postoperative day 1 Visual Analog Scale (Pod1 VAS), and intensive care unit (ICU) 
   admission. The nomogram demonstrated strong discriminatory ability and 
   calibration, with clinical utility confirmed through DCA and CICA. Higher 
   nomogram scores correlated with increased PPOI incidence.ConclusionsThe developed 
   nomogram is a valuable tool for early identification of PPOI in GC patients, 
   supporting clinicians and nurses in implementing personalized preventive 
   strategies.
C1 Department of Colorectal Surgery, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. RINGGOLD: 531909
   Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. RINGGOLD: 531909
   Department of Surgical Nursing, College of Nursing, Nanjing University of Chinese Medicine, Nanjing, China. RINGGOLD: 66478
   Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. RINGGOLD: 531909
   Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. RINGGOLD: 531909
   Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. RINGGOLD: 531909
   Department of Colorectal Surgery, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. RINGGOLD: 531909
   Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. RINGGOLD: 531909
NR 0
TC 0
SN 1555-982
EI 
J9 Am Surg
PD SEP 29
PY 2025
VL 0
IS 
BP 31348251383475
EP 31348251383475
DI 10.1177/00031348251383475 
PG 1
UT PubMed:41021978
PM 41021978
DA 2025-09-29
ER

PT J
AU Sheng, G
   Yang, J
   Rong, P
   Yang, X
AF Sheng, Guanyun
   Yang, Jing
   Rong, Peng
   Yang, Xueyi
TI Effects of Warm Needle Acupuncture plus Xitong Waixi Lotion in Patients with Knee 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB OBJECTIVE: To evaluate the effect of warm needle acupuncture plus Xitong Waixi 
   lotion on the levels of IL-1, TNF-α, and MMP-3 in patients with knee 
   osteoarthritis. METHODS: Eighty patients with knee osteoarthritis admitted to our 
   hospital from October 2019 to June 2021 were recruited and assigned via the 
   random number table method at a ratio of 1 : 1 to receive either Xitong Waixi 
   lotion (conventional group) or warm needle acupuncture plus Xitong Waixi lotion 
   (combined group). Outcome measures included clinical efficacy, inflammatory 
   cytokine level, Western Ontario and McMaster Universities Arthritis Index (WOMAC) 
   score, visual analogue scale (VAS) score, Hospital for Special Surgery (HSS) knee 
   score, and adverse reactions. RESULTS: Warm needle acupuncture plus Xitong Waixi 
   lotion was associated with a significantly higher clinical efficacy versus Xitong 
   Waixi lotion alone (P=0.006). Patients in the combined group had significantly 
   lower levels of interleukin (IL)-1, tumor necrosis factor-α (TNF-α), and matrix 
   metalloproteinase-3 (MMP-3) than those in the conventional group (P=0.020). Warm 
   needle acupuncture plus Xitong Waixi lotion resulted in significantly lower WOMAC 
   scores and VAS scores and higher HSS scores for the patients versus Xitong Waixi 
   lotion (P=0.012). The two groups had a similar incidence of adverse events 
   (P=0.068). CONCLUSION: Warm needle acupuncture plus Xitong Waixi lotion 
   effectively alleviates the inflammatory response and knee pain in patients with 
   knee osteoarthritis, with significant clinical effects and a high safety profile.
C1 Department of Orthopaedics, Liuzhou Traditional Chinese Medical Hospital, Guangxi University of Chinese Medicine, Liuzhou 545001, China.
   Intensive Care Unit, Liuzhou Traditional Chinese Medical Hospital, Guangxi University of Chinese Medicine, Liuzhou 545001, China.
   Graduate School, Guangxi University of Chinese Medicine, Nanning 530000, China.
   Department of Orthopaedics, Liuzhou Traditional Chinese Medical Hospital, Guangxi University of Chinese Medicine, Liuzhou 545001, China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD AUG 16
PY 2022
VL 2022
IS 
BP 5467712
EP 5467712
DI 10.1155/2022/5467712 
PG 0
UT PubMed:35966733
PM 35966733
DA 2022-08-16
ER

PT J
AU Yao, C
   Zeng, X
   Zhang, S
   Xiao, B
   Sun, P
   Kong, L
   Tao, J
   Fang, M
AF Yao, Chongjie
   Zeng, Xinyu
   Zhang, Shuaipan
   Xiao, Bin
   Sun, Pingping
   Kong, Lingjun
   Tao, Jiming
   Fang, Min
TI Acupoint massage: a comprehensive descriptive review of its forms, applications, 
SO Chinese medicine
LA English
DT Review
DE Acupoint; Acupressure; Massage; Mechanism; Tuina
AB Acupoint massage is a non-invasive traditional therapy that has demonstrated 
   reliable clinical outcomes in pain management, mental health relief, sleep 
   disorder regulation, gastrointestinal treatment, and as an adjunct therapy for 
   cancer. Its convenience and cost-effectiveness further enhance its appeal. 
   However, the existing English literature lacks a systematic review that 
   encompasses the various forms of acupoint massage. The acupoint massage forms 
   adaptability is particularly notable when considering the diverse conditions, it 
   addresses, as well as its applicability across different age groups and gender 
   differences. Providing a comprehensive understanding, it is crucial to outline 
   common practices and explore specific applications in key areas. The 
   comprehensive understanding can create opportunities for effective collaboration 
   between preclinical and clinical studies. Defining and categorizing different 
   forms of acupoint massage is essential, alongside investigating the neural 
   circuits involved in touch sensation. Future efforts should enhance collaboration 
   with modern biology, facilitating the transition from empirical to evidence-based 
   practice. This review summarizes forms, applications, and mechanisms of 
   mainstream acupoint massage and provides insights for future research and 
   applications, promoting deeper integration into healthcare.
C1 Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional 
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
   Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
   Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
   School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional 
   School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
   Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
   Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China. taoyecheng@163.com.
   Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China. fm-tn0510@shutcm.edu.cn.
   Research Institute of Tuina, Shanghai Academy of Traditional Chinese Medicine, 
NR 0
TC 0
SN 1749-854
EI 1749-854
J9 Chin Med
PD APR 24
PY 2025
VL 20
IS 1
BP 54
EP 54
DI 10.1186/s13020-025-01105-1 
PG 0
UT PubMed:40270014
PM 40270014
DA 2025-04-24
ER

PT J
AU Lin, LL
   Wang, YH
   Lai, CY
   Chau, CL
   Su, GC
   Yang, CY
   Lou, SY
   Chen, SK
   Hsu, KH
   Lai, YL
   Wu, WM
   Huang, JL
   Liao, CH
   Juan, HF
AF Lin, Li-Ling
   Wang, Ya-Hui
   Lai, Chi-Yu
   Chau, Chan-Lao
   Su, Guan-Chin
   Yang, Chun-Yi
   Lou, Shu-Ying
   Chen, Szu-Kai
   Hsu, Kuan-Hao
   Lai, Yen-Ling
   Wu, Wei-Ming
   Huang, Jian-Long
   Liao, Chih-Hsin
   Juan, Hsueh-Fen
TI Systems biology of meridians, acupoints, and chinese herbs in disease.
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Journal Article
AB Meridians, acupoints, and Chinese herbs are important components of traditional 
   Chinese medicine (TCM). They have been used for disease treatment and prevention 
   and as alternative and complementary therapies. Systems biology integrates omics 
   data, such as transcriptional, proteomic, and metabolomics data, in order to 
   obtain a more global and complete picture of biological activity. To further 
   understand the existence and functions of the three components above, we reviewed 
   relevant research in the systems biology literature and found many recent studies 
   that indicate the value of acupuncture and Chinese herbs. Acupuncture is useful 
   in pain moderation and relieves various symptoms arising from acute spinal cord 
   injury and acute ischemic stroke. Moreover, Chinese herbal extracts have been 
   linked to wound repair, the alleviation of postmenopausal osteoporosis severity, 
   and anti-tumor effects, among others. Different acupoints, variations in 
   treatment duration, and herbal extracts can be used to alleviate various symptoms 
   and conditions and to regulate biological pathways by altering gene and protein 
   expression. Our paper demonstrates how systems biology has helped to establish a 
   platform for investigating the efficacy of TCM in treating different diseases and 
   improving treatment strategies.
C1 Department of Life Science, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 106, Taiwan.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD NOV 3
PY 2012
VL 2012
IS 
BP 372670
EP 372670
DI 10.1155/2012/372670 
PG 0
UT PubMed:23118787
PM 23118787
DA 2012-11-03
ER

PT J
AU Liu, S
   Chen, Q
   Zhang, Q
   Tao, K
   Li, C
   Chang, B
   Wang, W
   Wu, Z
AF Liu, Shengfu
   Chen, Qiudan
   Zhang, Qinggang
   Tao, Kun
   Li, Changhong
   Chang, Baolei
   Wang, Weifeng
   Wu, Zhong
TI Electroacupuncture combined with extracorporeal shock wave therapy improves pain 
SO Heliyon
LA English
DT Journal Article
DE Electroacupuncture; Extracorporeal shock wave therapy; Knee osteoarthritis; Synovial fluid
AB OBJECTIVE: To compare the clinical efficacy and safety of electroacupuncture 
   combined with extracorporeal shock wave therapy (EESWT) and extracorporeal shock 
   wave therapy (ESWT) in the treatment of knee osteoarthritis (KOA). METHODS: A 
   total of 135 KOA patients who received EESWT treatment were selected as the EESWT 
   group, and 135 KOA patients who received extracorporeal shock wave therapy (ESWT) 
   were selected as the ESWT group. The clinical efficacy, inflammatory factors in 
   joint synovial fluid and adverse events during treatment were compared before and 
   after treatment. RESULTS: The clinical effective rate of patients in the EESWT 
   group (89.63 %) after treatment was significantly higher than that of the ESWT 
   group (74.81 %) (p < 0.01). The lysholm kness (LKSS) score and range of motion 
   (ROM) of the patients in the EESWT group after treatment were higher than those 
   of the ESWT group, while Lequesne index score, visual analogue scale (VAS) score 
   and Western Ontario and McMaster Universities Arthritis Index (WOMAC) were lower 
   than those of the ESWT group (p < 0.01). Compared with ESWT group, the changes in 
   the expression levels of nitric oxide (NO), superoxide dismutase (SOD), 
   interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α), matrix 
   metalloproteinase-3 (MMP-3), and transforming growth factor β1 (TGF-β1) in the 
   synovial fluid of the EESWT group after treatment were significantly greater than 
   those of the ESWT group (p < 0.01). No significant difference in the incidence of 
   adverse events between the EESWT group and the ESWT group (p > 0.05). CONCLUSION: 
   EESWT significantly improves pain symptoms and inflammatory factor levels in KOA 
   patients and is an optional KOA treatment option worthy of clinical attention.
C1 Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
   Department of Central Laboratory, Clinical Laboratory, Jing'an District Center Hospital of Shanghai, Fudan University, Shanghai 200040, China.
   Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
   Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
   Second Department of Surgery, People's Hospital of Gengma Dai and Va Autonomous County, Lincang, Yunnan 677599, China.
   Ma Anshan No.17 Metallurgical Hospital, Ma Anshan, Anhui 243000, China.
   Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
   Department of Laboratory Medicine, Longhua Hospital, Shanghai University of 
   Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
NR 0
TC 0
SN 2405-844
EI 2405-844
J9 Heliyon
PD OCT 16
PY 2023
VL 9
IS 10
BP e20771
EP e20771
DI 10.1016/j.heliyon.2023.e20771 
PG 1
UT PubMed:37842584
PM 37842584
DA 2023-10-16
ER

PT J
AU Jacobson, KA
   Reitman, ML
AF Jacobson, Kenneth A
   Reitman, Marc L
TI Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs.
SO Cells
LA English
DT Review
DE CNS; adenosine receptor; cardiovascular system; inflammation; nucleoside transport; pain
AB Many ligands directly target adenosine receptors (ARs). Here we review the 
   effects of noncanonical AR drugs on adenosinergic signaling. Non-AR mechanisms 
   include raising adenosine levels by inhibiting adenosine transport (e.g., 
   ticagrelor, ethanol, and cannabidiol), affecting intracellular metabolic pathways 
   (e.g., methotrexate, nicotinamide riboside, salicylate, and 
   5-aminoimidazole-4-carboxamide riboside), or undetermined means (e.g., 
   acupuncture). However, other compounds bind ARs in addition to their canonical 
   'on-target' activity (e.g., mefloquine). The strength of experimental support for 
   an adenosine-related role in a drug's effects varies widely. AR knockout mice are 
   the 'gold standard' method for investigating an AR role, but few drugs have been 
   tested on these mice. Given the interest in AR modulation for treatment of 
   cancer, CNS, immune, metabolic, cardiovascular, and musculoskeletal conditions, 
   it is informative to consider AR and non-AR adenosinergic effects of approved 
   drugs and conventional treatments.
C1 Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
   Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
NR 0
TC 0
SN 2073-440
EI 
J9 Cells
PD APR 17
PY 2020
VL 9
IS 4
BP 
EP 
DI 10.3390/cells9040956 
PG 0
WC Animals; Humans; Mice; Pharmaceutical Preparations; chemistry; Receptors, Purinergic P1; metabolism; Signal Transduction
UT PubMed:32295065
PM 32295065
DA 2020-04-17
ER

PT J
AU Chang, KL
   Fillingim, R
   Hurley, RW
   Schmidt, S
AF Chang, Ku-Lang
   Fillingim, Roger
   Hurley, Robert W
   Schmidt, Siegfried
TI Chronic pain management: nonpharmacological therapies for chronic pain.
SO FP essentials
LA English
DT Journal Article
AB Nonpharmacologic therapies have become a vital part of managing chronic pain 
   (CP). Although these can be used as stand-alone therapies, nonpharmacologic 
   treatments often are used to augment and complement pharmacologic treatments (ie, 
   multimodal therapy). Nonpharmacologic approaches can be classified as behavioral, 
   cognitive, integrative, and physical therapies. Core principles in developing a 
   treatment plan are explaining the nature of the CP condition, setting appropriate 
   goals, and developing a comprehensive treatment approach and plan for adherence. 
   Clinicians should become familiar with these interventions so that they can offer 
   patients flexibility in the pain management approach. Effective noninvasive 
   treatment modalities for CP include behavioral therapy for short-term pain 
   relief; cognitive behavioral therapy for reducing long-term pain and disability; 
   hypnosis as adjunctive therapy; guided imagery, diaphragmatic breathing, and 
   muscle relaxation, especially for cancer-related pain; mindfulness-based stress 
   reduction for patients with chronic low back pain; acupuncture for multiple pain 
   conditions; combination manipulation, manual therapy, endurance exercise, 
   stretching, and strengthening for chronic neck pain; animal-assisted therapy; and 
   S-adenosyl-L-methionine for joint pain. Guidelines for use of these treatment 
   modalities are based on expert panel recommendations in combination with data 
   from randomized controlled trials.
C1 University of Florida Health Family Medicine - Hampton Oaks, 200 SW 62nd Blvd Suite D, Gainesville, FL 32608, changk@shands.ufl.edu.
   Clinical and Translational Research Building Room 3216, 2004 Mowry Road, Gainesville, FL 32610-0404, RFillingim@dental.ufl.edu.
   MCW Pain Management Center, 959 N. North Mayfair Road, Milwaukee, WI 53226, rwhurley2010@gmail.com.
   University of Florida Health Family Medicine - Hampton Oaks, 200 SW 62nd Blvd Suite D, Gainesville, FL 32608, siggy@shands.ufl.edu.
NR 0
TC 0
SN 
EI 2159-300
J9 FP Essent
PD MAY 15
PY 2015
VL 432
IS 
BP 21
EP 6
DI 
PG -15
UT PubMed:25970869
PM 25970869
DA 2015-05-15
ER

PT J
AU Lu, C
   Bao, W
   Deng, D
   Li, R
   Li, G
   Zou, S
   Wang, Y
AF Lu, Chao
   Bao, Wenlong
   Deng, Dehou
   Li, Rongrong
   Li, Guangliang
   Zou, Shanlin
   Wang, Yan
TI Efficacy of electroacupuncture with different frequencies in the treatment of 
SO Frontiers in neurology
LA English
DT Journal Article
DE Mecobalamin; chemotherapy-induced peripheral neuropathy; electroacupuncture; protocol; randomized controlled trial
AB INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is a common 
   complication in patients with cancer during chemotherapy. It mainly leads to 
   severe numbness of the hands and feet and causes great pain in patients. 
   Electroacupuncture (EA) is considered to be beneficial in improving peripheral 
   neuropathy and relieving numbness of the hands and feet. This trial aims to 
   evaluate the therapeutic effect of different frequencies of EA on CIPN in 
   patients with cancer. METHODS AND ANALYSIS: This study is a randomized controlled 
   trial. In total, 160 eligible CIPN patients are randomly assigned to the 2 Hz EA 
   group, 100 Hz EA group, 2/100 Hz EA group, and control group in the ratio of 
   1:1:1:1. All patients in the EA treatment groups receive treatment with EA three 
   times a week for 4 weeks and following up for 4 weeks. The patients in the 
   control group are given Mecobalamin (MeCbl) tablets orally, one tablet at a time, 
   three times a day, for 4 weeks, and following up for 4 weeks. The primary outcome 
   measures are the participant neurotoxicity questionnaire (PNQ) and the peripheral 
   neurotoxicity assessment rating (NCI CTCAE V5.0). Secondary outcomes are the 
   quality of life scale (EORTC QLQ-C30) and the measurement of peripheral nerve 
   conduction velocity (NCV). The results are evaluated at baseline, post-treatment 
   phase, and following up for 4 weeks. All major analyses are based on the 
   intention to treat principle. ETHICS/DISSEMINATION: This protocol was approved by 
   the Medical Ethics Committee of the Cancer Hospital of the University of Chinese 
   Academy of Sciences (Zhejiang Cancer Hospital) on 7 December 2021. The license 
   number is IRB-2021-458. This study provides clinical efficacy data of different 
   frequencies of EA in the treatment of CIPN. The results help to prove whether EA 
   is an effective therapy for CIPN and optimize the frequency of EA for CIPN. The 
   results of this study are shared with health care professionals, the public, and 
   relevant organizations through the publication of manuscripts and conference 
   reports. TRIAL REGISTRATION NUMBER: ChiCTR2100054458.
C1 The Traditional Chinese Medicine Department, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou,China.
   The Traditional Chinese Medicine Department, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou,China.
   The Traditional Chinese Medicine Department, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou,China.
   The Third Clinical Medical College, Zhejiang University of Traditional Chinese Medicine, Hangzhou, China.
   Breast Medical Oncology Department, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.
   The Traditional Chinese Medicine Department, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou,China.
   The Traditional Chinese Medicine Department, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou,China.
NR 0
TC 0
SN 1664-229
EI 1664-229
J9 Front Neurol
PD AUG 16
PY 2022
VL 13
IS 
BP 843886
EP 843886
DI 10.3389/fneur.2022.843886 
PG 0
UT PubMed:35968286
PM 35968286
DA 2022-08-16
ER

PT J
AU Liu, JP
   Han, M
   Li, XX
   Mu, YJ
   Lewith, G
   Wang, YY
   Witt, CM
   Yang, GY
   Manheimer, E
   Snellingen, T
   Berman, B
   Gluud, C
AF Liu, Jian-Ping
   Han, Mei
   Li, Xin-Xue
   Mu, Yu-Jie
   Lewith, George
   Wang, Yu-Yi
   Witt, Claudia M
   Yang, Guo-Yan
   Manheimer, Eric
   Snellingen, Torkel
   Berman, Brian
   Gluud, Christian
TI Prospective registration, bias risk and outcome-reporting bias in randomised 
SO BMJ open
LA English
DT Journal Article
AB BACKGROUND: Clinical trials on Traditional Chinese Medicine (TCM) should be 
   registered in a publicly accessible international trial register and report on 
   all outcomes. We systematically assessed and evaluated TCM trials in registries 
   with their subsequent publications. OBJECTIVE: To describe the characteristics of 
   TCM trials, estimate bias risk and outcome-reporting bias in clinical trials. 
   DATA SOURCES AND STUDY SELECTION: Fifteen trial registries were searched from 
   their inception to July 2012 to identify randomised trials on TCM including 
   Chinese herbs, acupuncture and/or moxibustion, cupping, tuina, qigong, etc. DATA 
   EXTRACTION: We extracted data including TCM specialty and treated 
   disease/conditions from the registries and searched for subsequent publications 
   in PubMed and Chinese databases. We compared information in the registries of 
   completed trials with any publications focusing on study design, sample size, 
   randomisation, bias risk including reporting bias from the register protocol. 
   RESULTS: 1096 registered randomised trials were identified evaluating TCM, of 
   which 505 were completed studies (46.1%). The most frequent conditions were pain 
   (13.3%), musculoskeletal (11.7%), nervous (8.7%), digestive (7.1%), circulatory 
   (6.5%), respiratory (6.3%), mental and behavioural disorders (6.2%) and cancer 
   (6.0%). The trial register data identified parallel, phase II/III randomised 
   trials with sample size estimations and blinding, but limited information about 
   randomisation (sequence generation and allocation concealment). Comparing trial 
   registration data of 115 completed trials (22.8%) with their subsequent 136 
   publications, inconsistencies were identified in one or more of the following: 
   sample size (11%), outcome assessor blinding (37.5%), primary outcomes (29%) and 
   safety (28%) reporting. CONCLUSIONS: Increasing numbers of clinical trials 
   investigating a variety of TCM interventions have been registered in 
   international trial registries. The study design of registered TCM trials has 
   improved in estimating sample size, use of blinding and placebos. However, 
   selective outcome reporting is widespread and similar to conventional medicine 
   and therefore study conclusions should be interpreted with caution.
C1 Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
NR 0
TC 0
SN 2044-605
EI 
J9 BMJ Open
PD JUL 19
PY 2013
VL 3
IS 7
BP 
EP 
DI 10.1136/bmjopen-2013-002968 
PG 0
UT PubMed:23864210
PM 23864210
DA 2013-07-19
ER

PT J
AU Xu, Y
   Wu, G
   Zhang, G
   Li, D
   Zhang, L
   Yang, W
AF Xu, Yuanyuan
   Wu, Guangrong
   Zhang, Guomin
   Li, Dongxue
   Zhang, Lunyou
   Yang, Wei
TI Rare Emphysematous Osteomyelitis of the Femoral Head: A Case Report and 
SO Infection and drug resistance
LA English
DT Journal Article
DE CT; MRI; acupotomy; diabetes; emphysematous osteomyelitis
AB Emphysematous osteomyelitis (EO) is a perilous infection of the femoral head. In 
   this case, we present a 66-year-old male patient of Han ethnicity, who had lumbar 
   disc herniation and type 2 diabetes mellitus. The patient reported severe pain in 
   his lower back and right lower limb, which had worsened over the past 20 days. 
   Despite undergoing invasive procedures such as regional anesthetic blocks and 
   other traditional Chinese medical methods such as acupuncture and acupotomy, his 
   condition deteriorated. Pain in the lumbar region was not relieved, and there was 
   a new onset of pain in the right hip, groin, and thighs. Preliminary medical 
   evaluation revealed normal body temperature but elevated levels of the 
   inflammatory marker high-sensitivity C-reactive protein (hsCRP). In the imaging 
   tests, computed tomography revealed air bubbles within the right femoral head, 
   corresponding to the EO. Diabetes mellitus and malignant neoplasms have been 
   well-established as predominant risk factors for EO, while iatrogenic 
   interventions may serve as potential precipitating factors in disease 
   pathogenesis. Our report underlines the critical role of radiologists in 
   identifying EO through distinctive imaging features, such as the "pumice stone" 
   sign. This highlights the need for further research to enhance our understanding, 
   diagnosis, and management of EO.
C1 Department of Radiology, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, People'sRepublic of China.
   Department of Radiology, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, People'sRepublic of China.
   Department of Radiology, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, People'sRepublic of China.
   Department of Radiology, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, People'sRepublic of China.
   Department of Pathology, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, People'sRepublic of China.
   Department of Radiology, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, People'sRepublic of China.
NR 0
TC 0
SN 1178-697
EI 1178-697
J9 Infect Drug Resist
PD MAR 10
PY 2025
VL 18
IS 
BP 1279
EP 1285
DI 10.2147/IDR.S479261 
PG 6
UT PubMed:40059938
PM 40059938
DA 2025-03-10
ER

PT J
AU Burnstock, G
AF Burnstock, Geoffrey
TI Therapeutic potential of purinergic signalling for diseases of the urinary tract.
SO BJU international
LA English
DT Journal Article
AB This review begins with background information about the discovery and conceptual 
   steps contributing to our current knowledge of purinergic signalling. It then 
   deals with several topics concerned with the physiology and pathophysiology of 
   the lower urinary tract, including: the involvement in the voiding reflex of ATP 
   released as a co-transmitter with acetylcholine from parasympathetic nerves 
   supplying the bladder and ATP released from urothelial cells during bladder 
   distension to initiate the voiding reflex via P2X₃ receptors on suburothelial 
   low-threshold sensory nerve fibres; this latter mechanosensory transduction 
   pathway is also involved via high-threshold fibres in the initiation of pain. 
   Treatment of prostate and bladder cancer with ATP not only appears to be 
   effective against the primary tumours, but also improves the systemic symptoms 
   associated with advanced malignancy. There is dual control of the tone of blood 
   vessels: constriction by ATP released as a co-transmitter from sympathetic nerves 
   and vasodilatation via ATP released from endothelial cells during shear stress 
   acting on endothelial P2 receptors to release nitric oxide. A purinergic 
   hypothesis is discussed for the mechanism underlying acupuncture, widely used for 
   the treatment of urinary disorders.
C1 Autonomic Neuroscience Centre, University College Medical School, London, UK. g.burnstock@ucl.ac.uk
NR 0
TC 0
SN 1464-410
EI 
J9 BJU Int
PD JAN 7
PY 2011
VL 107
IS 2
BP 192
EP 204
DI 10.1111/j.1464-410X.2010.09926.x 
PG 12
WC Adenosine Triphosphate; physiology; Female; Humans; Male; Nitric Oxide; metabolism; Purinergic P2X Receptor Antagonists; therapeutic use; Signal Transduction; physiology; Urination; physiology; Urologic Diseases; physiopathology
UT PubMed:21208364
PM 21208364
DA 2011-01-07
ER

PT J
AU Mentink, M
   Verbeek, D
   Noordman, J
   Timmer-Bonte, A
   von, Rosenstiel I
   van, Dulmen S
AF Mentink, Marit
   Verbeek, Daniëlle
   Noordman, Janneke
   Timmer-Bonte, Anja
   von Rosenstiel, Ines
   van Dulmen, Sandra
TI The Effects of Complementary Therapies on Patient-Reported Outcomes: An Overview 
SO Cancers
LA English
DT Review
DE complementary medicine; meta-analysis; oncology; overview of systematic reviews; patient-reported outcomes (PROMS)
AB Many patients with cancer make use of complementary medicine alongside 
   conventional medicine, but clinicians in oncology often lack the knowledge to 
   adequately advise patients on the evidence base for complementary therapies. This 
   study aims to provide an overview of recently published systematic reviews that 
   assess the effects of complementary therapies on patient-reported health outcomes 
   in patients with cancer. Systematic reviews, including a meta-analysis of at 
   least two randomized controlled trials, were identified from the PubMed, Embase, 
   Cochrane Library, CINAHL and PsycINFO databases. The methodological quality was 
   assessed with AMSTAR 2. One hundred systematic reviews were included. The results 
   suggest that several complementary therapies can improve health outcomes reported 
   by patients with cancer, such as acupuncture to relieve pain, music interventions 
   to reduce anxiety and yoga to improve cancer-related fatigue. The side effects 
   related to complementary therapy use are generally mild. The results remain 
   inconclusive for some intervention-outcome combinations. Many of the included 
   systematic reviews insufficiently assessed the causes and impact of bias in their 
   interpretation of the results. This overview of systematic reviews can support 
   clinicians in counselling their patients on this topic and provide directions for 
   future research and clinical practice guidelines in the field of complementary 
   medicine.
C1 Nivel (Netherlands Institute of Health Services Research), Otterstraat 118, 3512 CR Utrecht, The Netherlands.
   Department of Primary and Community Care, Radboud Institute for Health Sciences, 
   Praktijk Integratieve Oncologie, Heesterpoort 18, 9713 KZ Groningen, The Netherlands.
   Nivel (Netherlands Institute of Health Services Research), Otterstraat 118, 3512 CR Utrecht, The Netherlands.
   Department of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
   Department of Integrative Oncology, Rijnstate Hospital, Wagnerlaan 55, 6815 AD Arnhem, The Netherlands.
   Nivel (Netherlands Institute of Health Services Research), Otterstraat 118, 3512 CR Utrecht, The Netherlands.
   Department of Primary and Community Care, Radboud Institute for Health Sciences, 
   Faculty of Caring Science, University of Borås, Work Life and Social Welfare, Allégatan 1, 501 90 Borås, Sweden.
NR 0
TC 0
SN 2072-669
EI 2072-669
J9 Cancers (Basel)
PD SEP 28
PY 2023
VL 15
IS 18
BP 
EP 
DI 10.3390/cancers15184513 
PG 0
UT PubMed:37760483
PM 37760483
DA 2023-09-28
ER

PT J
AU Ding, Y
   Cao, H
   Huang, Y
   Xue, H
   Cai, S
   Chen, X
   Duan, M
AF Ding, Yajun
   Cao, Hanzhong
   Huang, Ying
   Xue, Hong
   Cai, Shenquan
   Chen, Xiaohong
   Duan, Manlin
TI Fire Acupuncture Combined with Pulse Radiofrequency Relieves Tactile Allodynia in 
SO International journal of general medicine
LA English
DT Journal Article
DE P13K/AKT; fire acupuncture; postherpetic neuralgia; pulse radiofrequency
AB BACKGROUND: Postherpetic neuralgia (PHN) remains challenging to treat, with 
   40%-50% of patients experiencing inadequate pain relief despite comprehensive 
   interventions. Neuromodulation techniques such as pulsed radiofrequency (RF) and 
   traditional methods such as fire acupuncture (FA) are increasingly used for PHN. 
   This study investigated the combined effect of FA and RF on tactile allodynia in 
   a rat model of PHN and explored its underlying mechanisms. METHODS: Adult male 
   rats were randomly divided into: Control, PHN, FA, RF, and combined FA_RF groups. 
   PHN was induced by varicella-zoster virus inoculation. FA and/or RF interventions 
   began on Day 15. Pain behavior was assessed via mechanical allodynia and thermal 
   hyperalgesia tests. On Day 37, spinal cord tissues and cerebrospinal fluid were 
   collected to evaluate astrocyte and microglial activation, neuronal apoptosis, 
   expression of Insulin-Like Growth Factor 2 (IGF2), Peripheral Myelin Protein 2 
   (PMP2), Claudin-19 (CLDN19), Homeobox C8 (HOXC8), and levels of interleukin-1β 
   (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis 
   factor-α (TNF-α). The role of the phosphatidylinositol 3-kinase (PI3K)/protein 
   kinase B (AKT) pathway was verified using a PI3K/AKT agonist. RESULTS: The 
   results revealed that mechanical allodynia thresholds decreased on Day 8 
   post-inoculation. Compared to the PHN group, FA_RF combination significantly 
   increased mechanical thresholds and prolonged thermal hyperalgesia latency, with 
   superior effects versus FA or RF alone. The FA_RF group showed increased spinal 
   IGF2, PMP2, and CLDN19 expression, decreased HOXC8, reduced astrocyte activation, 
   and modulated cytokine levels (IL-1β, IL-6, TNF-α, IL-10). The PI3K/AKT agonist 
   reversed the analgesic effects of FA_RF. CONCLUSION: Combined fire acupuncture 
   and pulsed radiofrequency alleviates tactile allodynia in PHN rats, possibly by 
   inhibiting spinal astrocyte activation, modulating inflammatory responses, and 
   promoting nerve repair via IGF2, PMP2, and CLDN19 expression. The PI3K/AKT 
   pathway may be critically involved in this analgesic mechanism.
C1 Department of Anesthesiology, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210002, People's Republic of China.
   Tumor Hospital Affiliated to Nantong University, Nantong Tumor Hospital, Nantong, 
   Tumor Hospital Affiliated to Nantong University, Nantong Tumor Hospital, Nantong, 226361, People's Republic of China.
   Department of Pain Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, People's Republic of China.
   Department of Anesthesiology, The Affiliated Huaian Hospital of Xuzhou Medical University and Huaian Second People's Hospital, Huai'an, 223002, People'sRepublic of China.
   Department of Pain Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, People's Republic of China.
   Tumor Hospital Affiliated to Nantong University, Nantong Tumor Hospital, Nantong, 226361, People's Republic of China.
   Department of Anesthesiology, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210002, People's Republic of China.
NR 0
TC 0
SN 1178-707
EI 1178-707
J9 Int J Gen Med
PD SEP 25
PY 2025
VL 18
IS 
BP 5699
EP 5716
DI 10.2147/IJGM.S541807 
PG 17
UT PubMed:40994884
PM 40994884
DA 2025-09-25
ER

PT J
AU Kim, S
   Chen, N
   Reid, P
AF Kim, Sara
   Chen, Nan
   Reid, Pankti
TI Current and future advances in practice: aromatase inhibitor-induced arthralgia.
SO Rheumatology advances in practice
LA English
DT Review
DE aromatase inhibitor; aromatase inhibitor–associated joint pain; arthralgia; arthritis; breast cancer
AB Aromatase inhibitors (AIs) have shown great success as adjuvant therapy for 
   post-menopausal women with hormone receptor-positive breast cancers. AI-induced 
   arthralgia (AIA) is a frequent AI toxicity contributing to non-adherence and 
   discontinuation. This review aims to understand current knowledge of AIA. The 
   mean incidence of AIA was 39.1% and the mean discontinuation of AI therapy due to 
   AIA was 9.3%. Most of the AIAs were non-inflammatory. A shorter time since the 
   last menstrual period and pre-existing joint pain were risk factors. Vitamin D3 
   supplementation may be a preventative measure and treatment with duloxetine, 
   acupuncture and/or exercise is supported by large randomized controlled trials. 
   There was consistent improvement in AIAs with switching to an alternate AI, and 
   this could additionally allow continuation of cancer treatment with AI. Further 
   research is needed to identify predictive biomarkers, better characterize AIA 
   subcategories and study more reliable therapeutic options.
C1 Department of Medicine, University of Chicago, Chicago, IL, USA.
   Division of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
   Division of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
NR 0
TC 0
SN 2514-177
EI 
J9 Rheumatol Adv Pract
PD APR 11
PY 2024
VL 8
IS 2
BP rkae024
EP rkae024
DI 10.1093/rap/rkae024 
PG 1
UT PubMed:38601139
PM 38601139
DA 2024-04-11
ER

PT J
AU Cao, Y
   Jing, F
   Jiang, L
   Tian, M
   Qiu, J
   Tang, L
   Hu, Y
AF Cao, Yuling
   Jing, Feng
   Jiang, Lingyun
   Tian, Maoting
   Qiu, Jiajia
   Tang, Lichen
   Hu, Yan
TI The experience of musculoskeletal symptoms among patients with breast cancer 
SO Asia-Pacific journal of oncology nursing
LA English
DT Journal Article
DE Aromatase inhibitor therapy; Breast cancer; Musculoskeletal symptoms; Qualitative study; Symptom experience; Symptom management
AB OBJECTIVE: To examine the musculoskeletal symptom experiences of Chinese patients 
   with breast cancer receiving aromatase inhibitor (AI) therapy and identify 
   patient-centered strategies for symptom management. METHODS: A descriptive 
   qualitative study was conducted from June to August 2023 at a tertiary hospital 
   in Shanghai, China. Using purposive sampling with maximum variation, 37 women 
   with hormone receptor-positive (HR+) breast cancer (stages I-III) undergoing AI 
   therapy participated in semi-structured telephone interviews. Data were 
   audio-recorded, transcribed verbatim, and analyzed thematically. RESULTS: Four 
   themes were identified: (1) Symptom burden-persistent joint pain, stiffness, and 
   fatigue interfered with daily activities; (2) Emotional impact-symptoms provoked 
   anxiety, frustration, and reduced well-being; (3) Social challenges-decreased 
   participation in social and family life led to feelings of isolation; and (4) 
   Coping strategies-pharmacological measures (e.g., calcium and vitamin D 
   supplementation) and non-pharmacological interventions (e.g., exercise, 
   acupuncture) were adopted, though access to reliable information and professional 
   guidance was often inadequate. CONCLUSIONS: Musculoskeletal symptoms related to 
   AI therapy impose considerable physical, emotional, and social burdens on Chinese 
   patients with breast cancer, potentially undermining treatment adherence. 
   Culturally appropriate, patient-centered management incorporating both 
   pharmacological and non-pharmacological interventions is essential to optimize 
   symptom control and quality of life.
C1 School of Nursing, Fudan University, Shanghai, China.
   School of Nursing, Fudan University, Shanghai, China.
   Fudan University Shanghai Cancer Center, Shanghai, China.
   School of Nursing, Fudan University, Shanghai, China.
   School of Nursing, Fudan University, Shanghai, China.
   Fudan University Shanghai Cancer Center, Shanghai, China.
   Fudan University Shanghai Cancer Center, Shanghai, China.
   School of Nursing, Fudan University, Shanghai, China.
NR 0
TC 0
SN 2349-667
EI 2347-562
J9 Asia Pac J Oncol Nurs
PD OCT 6
PY 2025
VL 12
IS 
BP 100784
EP 100784
DI 10.1016/j.apjon.2025.100784 
PG 0
UT PubMed:41048407
PM 41048407
DA 2025-10-06
ER

PT J
AU Seddio, AE
   Dhodapkar, MM
   Halperin, SJ
   Jabbouri, SS
   Gouzoulis, MJ
   Joo, PY
   Grauer, JN
AF Seddio, Anthony E
   Dhodapkar, Meera M
   Halperin, Scott J
   Jabbouri, Sahir S
   Gouzoulis, Michael J
   Joo, Peter Y
   Grauer, Jonathan N
TI Predictors of Physical, Chiropractic, and Acupuncture Therapy Utilization in the 
SO Clinical spine surgery
LA English
DT Journal Article
DE acupuncture; chiropractic; conservative management; low back pain; national database study; physical therapy; resource utilization; therapy utilization
AB STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To assess the relative 
   utilization and predictors of physical therapy (PT), chiropractic therapy (CT), 
   and acupuncture therapy (AT) within 90 days of low back pain (LBP) diagnosis. 
   BACKGROUND: LBP is the most common musculoskeletal problem globally. Following 
   diagnosis, patients often seek treatments including PT, CT, and AT, however, 
   their relative use and drivers of therapeutic selection remain poorly 
   characterized. METHODS: Adults diagnosed with LBP who utilized PT, CT, or AT 
   within 90 days were identified from the PearlDiver M161 database. Exclusion 
   criteria included: therapy utilization before diagnosis and those presenting for 
   trauma, neoplasm, or infection. Patients utilizing each therapy type were 
   characterized based on clinical and nonclinical factors and compared by 
   univariable analyses and multivariable logistic regression. RESULTS: Of 
   10,046,167 LBP patients, no therapy/other was noted for 9,560,636 (94.78%), PT 
   for 413,554 (4.10%), CT for 103,444 (1.03%), and AT for 10,026 
   (0.10%).Independent predictors of CT utilization, relative to PT, were lower age 
   [per decade increase: odds ratio (OR): 0.986], male sex (OR: 1.046), lower 
   Elixhauser Comorbidity Index (ECI, per 1-point increase: OR: 0.882), lower mean 
   family income: (OR: 0.999), lower unemployment: (OR: 0.888), region (relative to 
   South: Northeast OR: 0.773, Midwest OR: 1.265), and insurance (relative to 
   commercial: Medicaid OR: 0.489, Medicare OR: 0.896; P <0.001 for all).Independent 
   predictors of AT utilization, relative to PT, were lower ECI (OR: 0.960), higher 
   mean family income (OR: 1.0000160), region (West OR: 2.214, Northeast OR: 1.390, 
   Midwest OR: 1.293), and insurance (Medicaid OR: 0.372, Medicare OR: 0.510; P 
   <0.001 for all). CONCLUSIONS: PT was more frequently utilized than both CT and AT 
   within 90 days of LBP diagnosis. However, clinical and nonclinical factors proved 
   to be significant predictors for patients who utilized CT and AT versus PT. 
   Understanding these drivers helps characterize therapy utilization patterns at a 
   national level, an area previously not well defined. LEVEL OF EVIDENCE: Level 
   III.
C1 Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT.
NR 0
TC 0
SN 2380-019
EI 
J9 Clin Spine Surg
PD JUN 16
PY 2025
VL 0
IS 
BP 
EP 
DI 10.1097/BSD.0000000000001859 
PG 0
UT PubMed:40521727
PM 40521727
DA 2025-06-16
ER

PT J
AU Lo, YJ
   Mishra, VK
   Lo, HY
   Dubey, NK
   Lo, WC
AF Lo, Yun-Jo
   Mishra, Viraj Krishna
   Lo, Hung-Yao
   Dubey, Navneet Kumar
   Lo, Wen-Cheng
TI Clinical Spectrum and Trajectory of Innovative Therapeutic Interventions for 
SO Aging and disease
LA English
DT Journal Article
AB Increasing incidences of insomnia in adults, as well as the aging population, 
   have been reported for their negative impact on the quality of life. Insomnia 
   episodes may be associated with neurocognitive, musculoskeletal, cardiovascular, 
   gastrointestinal, renal, hepatic, and metabolic disorders. Epidemiological 
   evidence also revealed the association of insomnia with oncologic and asthmatic 
   complications, which has been indicated as bidirectional. Two therapeutic 
   approaches including cognitive behavioral therapy (CBT) and drugs-based therapies 
   are being practiced for a long time. However, the adverse events associated with 
   drugs limit their wide and long-term application. Further, Traditional Chinese 
   medicine, acupressure, and pulsed magnetic field therapy may also provide 
   therapeutic relief. Notably, the recently introduced cryotherapy has been 
   demonstrated as a potential candidate for insomnia which could reduce pain, by 
   suppressing oxidative stress and inflammation. It seems that the synergistic 
   therapeutic approach of cryotherapy and the above-mentioned approaches might 
   offer promising prospects to further improve efficacy and safety. Considering 
   these facts, this perspective presents a comprehensive summary of recent advances 
   in pathological aetiologies of insomnia including COVID-19, and its therapeutic 
   management with a greater emphasis on cryotherapy.
C1 EUDA Wellness, Taipei 114, Taiwan.
   Biosource Tech, Ambala 133101, Haryana, India.
   EUDA Wellness, Taipei 114, Taiwan.
   Victory Biotechnology Co., Ltd., Taipei 114757, Taiwan.
   ShiNeo Technology Co., Ltd., New Taipei City 24262, Taiwan.
   Department of Surgery, Division of Neurosurgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
   Department of Neurosurgery, Taipei Medical University Hospital, Taipei 11031, 
   Taipei Neuroscience Institute, Taipei Medical University, Taipei 11031, Taiwan.
NR 0
TC 0
SN 2152-525
EI 2152-525
J9 Aging Dis
PD MAY 10
PY 2023
VL 14
IS 4
BP 1038
EP 1069
DI 10.14336/AD.2022.1203 
PG 31
UT PubMed:37163444
PM 37163444
DA 2023-05-10
ER

PT J
AU Liedtke, W
AF Liedtke, Wolfgang
TI Long March Toward Safe and Effective Analgesia by Enhancing Gene Expression of 
SO Frontiers in molecular neuroscience
LA English
DT Review
DE GSK3; KCC2; Kaiso; Kcc2 gene expression enhancer; delta-catenin; pain; spinal cord dorsal horn
AB Low intraneuronal chloride in spinal cord dorsal horn pain relay neurons is 
   critical for physiologic transmission of primary pain afferents because low 
   intraneuronal chloride dictates whether GABA-ergic and glycin-ergic 
   neurotransmission is inhibitory. If the neuronal chloride elevates to pathologic 
   levels, then spinal cord primary pain relay becomes leaky and exhibits the 
   behavioral hallmarks of pathologic pain, namely hypersensitivity and allodynia. 
   Low chloride in spinal cord dorsal horn neurons is maintained by proper gene 
   expression of Kcc2 and sustained physiologic function of the KCC2 chloride 
   extruding electroneutral transporter. Peripheral nerve injury and other forms of 
   neural injury evoke greatly diminished Kcc2 gene expression and subsequent 
   corruption of inhibitory neurotransmission in the spinal cord dorsal horn, thus 
   causing derailment of the gate function for pain. Here I review key discoveries 
   that have helped us understand these fundamentals, and focus on recent insights 
   relating to the discovery of Kcc2 gene expression enhancing compounds via 
   compound screens in neurons. One such study characterized the kinase inhibitor, 
   kenpaullone, more in-depth, revealing its function as a robust and long-lasting 
   analgesic in preclinical models of nerve injury and cancer bone pain, also 
   elucidating its mechanism of action via GSK3β inhibition, diminishing 
   delta-catenin phosphorylation, and facilitating its nuclear transfer and 
   subsequent enhancement of Kcc2 gene expression by de-repressing Kaiso epigenetic 
   transcriptional regulator. Future directions re Kcc2 gene expression enhancement 
   are discussed, namely combination with other analgesics and analgesic methods, 
   such as spinal cord stimulation and electroacupuncture, gene therapy, and 
   leveraging Kcc2 gene expression-enhancing nanomaterials.
C1 Regeneron Pharmaceuticals, Global Development Scientific Council, Tarrytown, NY, United States.
NR 0
TC 0
SN 1662-509
EI 1662-509
J9 Front Mol Neurosci
PD JUN 2
PY 2022
VL 15
IS 
BP 865600
EP 865600
DI 10.3389/fnmol.2022.865600 
PG 0
UT PubMed:35645734
PM 35645734
DA 2022-06-02
ER

PT J
AU Adams, R
   White, B
   Beckett, C
AF Adams, Rose
   White, Barb
   Beckett, Cynthia
TI The effects of massage therapy on pain management in the acute care setting.
SO International journal of therapeutic massage & bodywork
LA English
DT Journal Article
DE Massage therapy; Swedish effleurage; acupressure; acute care; anxiety; cancer; craniosacral; fibromyalgia; hospital; inpatients; pain management; patient care management; postoperative pain; pregnancy; reflexology; relaxation; research
AB BACKGROUND: Pain management remains a critical issue for hospitals and is 
   receiving the attention of hospital accreditation organizations. The acute care 
   setting of the hospital provides an excellent opportunity for the integration of 
   massage therapy for pain management into the team-centered approach of patient 
   care. PURPOSE AND SETTING: This preliminary study evaluated the effect of the use 
   of massage therapy on inpatient pain levels in the acute care setting. The study 
   was conducted at Flagstaff Medical Center in Flagstaff, Arizona-a nonprofit 
   community hospital serving a large rural area of northern Arizona. METHOD: A 
   convenience sample was used to identify research participants. Pain levels before 
   and after massage therapy were recorded using a 0 - 10 visual analog scale. 
   Quantitative and qualitative methods were used for analysis of this descriptive 
   study. PARTICIPANTS: Hospital inpatients (n = 53) from medical, surgical, and 
   obstetrics units participated in the current research by each receiving one or 
   more massage therapy sessions averaging 30 minutes each. The number of sessions 
   received depended on the length of the hospital stay. RESULT: Before massage, the 
   mean pain level recorded by the patients was 5.18 [standard deviation (SD): 
   2.01]. After massage, the mean pain level was 2.33 (SD: 2.10). The observed 
   reduction in pain was statistically significant: paired samples t(52) = 12.43, r 
   = .67, d = 1.38, p < .001. Qualitative data illustrated improvement in all areas, 
   with the most significant areas of impact reported being overall pain level, 
   emotional well-being, relaxation, and ability to sleep. CONCLUSIONS: This study 
   shows that integration of massage therapy into the acute care setting creates 
   overall positive results in the patient's ability to deal with the challenging 
   physical and psychological aspects of their health condition. The study 
   demonstrated not only significant reduction in pain levels, but also the 
   interrelatedness of pain, relaxation, sleep, emotions, recovery, and finally, the 
   healing process.
C1 Therapy Services, Massage Therapy;
NR 0
TC 0
SN 1916-257
EI 
J9 Int J Ther Massage Bodywork
PD JAN 1
PY 2010
VL 3
IS 1
BP 4
EP 11
DI 
PG 7
UT PubMed:21589696
PM 21589696
DA 2010-01-01
ER

PT J
AU Mok, S
   Chu, EC
AF Mok, Sharon
   Chu, Eric Chun-Pu
TI The Importance of Early Detection of Spinal Tumors Through Magnetic Resonance 
SO Cureus
LA English
DT Journal Article
DE back pain; chiropractic; chiropractor; magnetic resonance imaging; radiculopathy; schwannoma; spine tumor
AB Primary spinal tumors such as schwannomas are uncommon causes of back pain that 
   can be easily missed during the initial workup. Delayed diagnosis is associated 
   with further neurological impairment. A 46-year-old man presented with a 
   six-month history of progressive lower back pain and left leg radiculopathy. 
   Previous treatments failed, including medications, physical therapy, acupuncture, 
   and chiropractic manipulations. Examination revealed weakness (4/5) in left knee 
   extension and ankle dorsiflexion. Magnetic resonance imaging (MRI) revealed a 
   2-cm intraspinal schwannoma at the L4 level with nerve root compression. The 
   patient underwent laminectomy and gross total resection without any 
   complications. The patient had near-complete symptomatic resolution six weeks 
   postoperatively and returned to normal functioning. After four months of 
   postoperative rehabilitation, the patient remained asymptomatic. This case 
   reinforces the urgent need for early MRI in the presence of neurological deficits 
   and other symptoms, despite normal radiographs. An increased suspicion of spinal 
   tumors can prevent delays in diagnosis and minimize adverse outcomes. 
   Multidisciplinary care optimizes the treatment of complex cases.
C1 Chiropractic and Physiotherapy Clinic, New York Medical Group, Hong Kong, CHN.
   Chiropractic and Physiotherapy Clinic, New York Medical Group, Hong Kong, CHN.
NR 0
TC 0
SN 2168-818
EI 2168-818
J9 Cureus
PD FEB 1
PY 2024
VL 16
IS 1
BP e51440
EP e51440
DI 10.7759/cureus.51440 
PG 1
UT PubMed:38298283
PM 38298283
DA 2024-02-01
ER

PT J
AU Jayatilleke, A
AF Jayatilleke, Arundathi
TI Arthritis: Rheumatoid Arthritis.
SO FP essentials
LA English
DT Review
AB Key principles of rheumatoid arthritis (RA) management include early patient 
   evaluation by a rheumatologist and early initiation of pharmacologic therapy in 
   patients at risk for chronic disease. Early diagnosis and appropriate management 
   are essential to prevent joint damage. Patients with RA usually report pain and 
   swelling in multiple joints and prolonged stiffness in the morning that improves 
   with activity. Joint involvement typically is bilateral and symmetric. RA affects 
   large and small joints, particularly the metacarpophalangeal and proximal 
   interphalangeal joints of the hands. Patients with RA may be started on 
   nonsteroidal anti-inflammatory drugs, glucocorticoids, or conventional synthetic 
   disease-modifying antirheumatic drugs (DMARDs) before evaluation by a 
   rheumatologist. Patients who have a poor response to conventional synthetic 
   DMARDs or aggressive arthritis at initial evaluation may be prescribed biologic 
   or targeted synthetic DMARDs. Anti-tumor necrosis factor alpha agents also may be 
   used. Patients typically are managed with a treat-to-target strategy to achieve 
   and maintain low disease activity or remission. Regular monitoring visits using 
   formal assessment of disease activity have been shown to improve outcomes. RA and 
   the medications used in its treatment are associated with increased risks of 
   infections and malignancy. Integrative medicine therapies with limited evidence 
   include acupuncture, mind-body therapies (eg, yoga, tai chi), and dietary 
   supplements.
C1 Department of Medicine at Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
NR 0
TC 0
SN 
EI 2159-300
J9 FP Essent
PD JAN 22
PY 2025
VL 548
IS 
BP 25
EP 30
DI 
PG 5
WC Humans; Arthritis, Rheumatoid; diagnosis; Antirheumatic Agents; therapeutic use; Glucocorticoids; therapeutic use; Anti-Inflammatory Agents, Non-Steroidal; therapeutic use; Tumor Necrosis Factor-alpha; antagonists & inhibitors
UT PubMed:39836893
PM 39836893
DA 2025-01-22
ER

PT J
AU Chen, S
   Ding, Y
   Zhang, X
   Zhang, X
   Xiang, J
   Deng, Y
   Tao, X
   Cai, W
   Li, Z
   Chen, J
   Kong, F
   Li, N
AF Chen, Shuang
   Ding, Ying
   Zhang, Xiaoming
   Zhang, Xue
   Xiang, Jiajia
   Deng, Yiling
   Tao, Xingran
   Cai, Wenke
   Li, Zhigui
   Chen, Jiayu
   Kong, Fanyi
   Li, Na
TI Efficacy of Transcutaneous Electrical Acupoint Stimulation on Chronic 
SO Pain and therapy
LA English
DT Journal Article
DE Anesthesia pain management; Transcutaneous electrical acupuncture stimulation; Trial protocol; Video-assisted thoracoscopic lobectomy
AB INTRODUCTION: Patients undergoing video-assisted thoracoscopic lobectomy (VATL) 
   often experience chronic postsurgical pain (CPSP). Postoperative pain can affect 
   the recovery of postoperative lung function, prolong postoperative recovery time, 
   and increase patient hospitalization expenses. Transcutaneous electrical acupoint 
   stimulation (TEAS) is an alternative therapy based on acupuncture that has shown 
   promise in postoperative recovery and pain management across various medical 
   fields. However, research specifically focused on the improvement of CPSP after 
   VATL is currently lacking. The purpose of this study is to evaluate whether TEAS 
   can effectively reduce the severity and occurrence of chronic postsurgical pain 
   in patients undergoing VATL. By investigating the potential benefits of TEAS in 
   mitigating CPSP after VATL, this study aims to provide valuable clinical evidence 
   to support the integration of TEAS into postoperative care protocols for patients 
   undergoing VATL. METHODS: This study is a prospective, single-center, 
   double-blinded, randomized controlled trial to be conducted at the 920th Hospital 
   of Joint Logistics Support Force. Eighty patients undergoing VATL will be 
   randomly divided into an experimental group (TEAS group) and a control group 
   (sham group). The experimental group will receive TEAS at bilateral PC6, LI4, 
   LR3, LU5, TE5, and LI11. The control group will not receive TEAS at the same 
   acupoints. Both groups will receive TEAS or no TEAS before anesthesia induction 
   and 1-7 days after surgery, with each session lasting 30 min. PLANNED OUTCOMES: 
   The primary outcome will be the incidence of CPSP at 3 months after surgery. 
   Secondary outcomes will include the incidence of CPSP at 6 months after surgery, 
   the numerical rating scale (NRS) scores at 3 and 6 months after surgery, as well 
   as the NRS scores at 24, 48, and 72 h after surgery, remifentanil consumption 
   during general anesthesia, demand for rescue analgesics, number and duration of 
   indwelling chest tubes, incidence of postoperative nausea and vomiting, and 
   changes of norepinephrine (NE), cortisol (Cor), tumor necrosis factor (TNF- α), 
   and interleukin 6 (IL-6) in serum. TRIAL REGISTRATION: ChiCTR2300069458. 
   Registered on March 16, 2023.
C1 Department of Anesthesiology, 920th Hospital of Joint Logistics Support Force, 212 Daguan Road, Xishan District, Kunming, Yunnan, China.
   Kunming Medical University, Kunming, Yunnan, China.
   Department of General Surgery, 920th Hospital of Joint Logistics Support Force, 212 Daguan Road, Xishan District, Kunming, Yunnan, China.
   Department of Anesthesiology, 920th Hospital of Joint Logistics Support Force, 212 Daguan Road, Xishan District, Kunming, Yunnan, China.
   Department of Anesthesiology, 920th Hospital of Joint Logistics Support Force, 212 Daguan Road, Xishan District, Kunming, Yunnan, China.
   Kunming Medical University, Kunming, Yunnan, China.
   Department of Anesthesiology, 920th Hospital of Joint Logistics Support Force, 212 Daguan Road, Xishan District, Kunming, Yunnan, China.
   Kunming Medical University, Kunming, Yunnan, China.
   Kunming Medical University, Kunming, Yunnan, China.
   Department of Orthopedics, The First People's Hospital of Yunnan Province, Xishan 
   Department of Anesthesiology, 920th Hospital of Joint Logistics Support Force, 212 Daguan Road, Xishan District, Kunming, Yunnan, China.
   Department of Cardiothoracic Surgery, 920th Hospital of Joint Logistics Support Force, 212 Daguan Road, Xishan District, Kunming, Yunnan, China.
   Department of Anesthesiology, 920th Hospital of Joint Logistics Support Force, 212 Daguan Road, Xishan District, Kunming, Yunnan, China.
   Department of Orthopedics, The First People's Hospital of Yunnan Province, Xishan District, Kunming, Yunnan, China.
   Department of Neurology, Affiliated Hospital of Yunnan University, 176 Qingnian Road, Wuhua District, Kunming, Yunnan, China.
   Department of Anesthesiology, 920th Hospital of Joint Logistics Support Force, 212 Daguan Road, Xishan District, Kunming, Yunnan, China. lina@kmmu.edu.cn.
NR 0
TC 0
SN 2193-651
EI 2193-823
J9 Pain Ther
PD FEB 17
PY 2024
VL 13
IS 2
BP 269
EP 280
DI 10.1007/s40122-024-00580-y 
PG 11
UT PubMed:38367159
PM 38367159
DA 2024-02-17
ER

PT J
AU Xu, G
   Lei, H
   Zhou, Y
   Huang, L
   Tian, H
   Zhou, Z
   Zhao, L
   Liang, F
AF Xu, Guixing
   Lei, Hanzhou
   Zhou, Yuanfang
   Huang, Liuyang
   Tian, Hao
   Zhou, Zhuo
   Zhao, Ling
   Liang, Fanrong
TI Acupuncture for Quality of Life of Patients with Defecation Dysfunction after 
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Review
AB PURPOSE: To evaluate the effectiveness and safety of acupuncture for quality of 
   life of patients with defecation dysfunction (DD) after sphincter preserving 
   surgery for rectal cancer. METHODS: We searched nine online databases from 
   inception to July 1, 2021, and did not restrict the type of language. Then, 
   studies were independently selected by two research team members with screening 
   criteria and risk bias assessment, and the data were extracted. The primary 
   outcome was Quality of Life Questionnaire-Core 29 (QLQ-CR29). The data were then 
   synthesized using the RevMan V.5.2 by random-effects model. Also, we used the 
   standardized mean differences with 95% credible interval (CI) to describe the 
   outcome of the analysis. RESULTS: A total of 6 randomized controlled trials 
   (RCTs) (with 439 patients) were included in the systematic review, and data from 
   2 RCTs (with 200 patients) were used in the meta-analysis. Five studies (83%) 
   were judged to have a medium risk of bias, and one was at high risk of bias. For 
   synthesis, data from two medium-risk studies found that acupuncture or 
   electropuncture may improve the QLQ-CR29 with urination (mean difference, -0.39 
   points; 95%CI, -0.46 to -0.32; I (2) = 34%), abdominal pain (mean difference, 
   -0.71 points; 95%CI, -0.89 to -0.54; I (2) = 9%), stool (mean difference, -0.49 
   points; 95%CI, -0.77 to -0.20; I (2) = 57%), defecation (mean difference, -0.59 
   points; 95% CI, -0.85 to -0.33; I (2) = 51%), sexual function (mean difference, 
   0.93 points; 95% CI, 0.48 to 1.38; I (2) = 90%), and self-feelings (mean 
   difference, 1.04 points; 95% CI, 0.36 to 1.73; I (2) = 94%). CONCLUSION: Findings 
   in this study indicate that acupuncture or electropuncture may be effective and 
   safe for DD, but the quality of included studies was very low. So, more 
   large-scale, multicenter, long-term, and high-quality original research is still 
   expected in the future.
C1 Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
   Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD DEC 28
PY 2021
VL 2021
IS 
BP 7858252
EP 7858252
DI 10.1155/2021/7858252 
PG 0
UT PubMed:34956383
PM 34956383
DA 2021-12-28
ER

PT J
AU Shrateh, ON
   Habib, A
   Ur, Rehman Shamsi H
   Kumar, KA
   Mousa, Omar BM
   Mansour, A
   Mohsen, M
   Hamad, AM
   Mair, M
   Sahota, B
AF Shrateh, Oadi N
   Habib, Ashna
   Ur Rehman Shamsi, Hammad
   Kumar, Kanwal Ashok
   Mousa Omar, Belal Mohammad
   Mansour, Ahmad
   Mohsen, Mahmoud
   Hamad, Ali M
   Mair, Manish
   Sahota, Bindy
TI Treatment options for radiation-induced xerostomia in patients with head and neck 
SO The British journal of oral & maxillofacial surgery
LA English
DT Review
DE head and neck cancer; radiotherapy; salivary gland dysfunction; xerostomia
AB Radiation-induced xerostomia is a frequent and debilitating complication in 
   patients undergoing radiotherapy for head and neck cancer. This study aimed to 
   compare the effectiveness of available treatment modalities in preventing or 
   managing radiation-induced xerostomia and associated complications in head and 
   neck cancer patients. A detailed search of PubMed and Google Scholar was 
   conducted. Only randomised controlled trials (RCTs) involving 
   radiotherapy-treated head and neck cancer patients were included. The 
   interventions that were analysed encompassed pharmacological agents (for example, 
   pilocarpine, and amifostine), antioxidants, herbal formulations, acupuncture, 
   low-level laser therapy (LLLT), and regenerative approaches. Primary outcomes 
   included severity of xerostomia, rates of salivary flow, mucositis, oral pain, 
   dysphagia, and fatigue. Thirty-one randomised clinical trials met the inclusion 
   criteria. Pooled analysis showed no significant reduction in severity of 
   xerostomia at weeks 3, 4, or 6, or 6 months. Stimulated salivary flow did not 
   significantly improve (mean difference (MD): 0.22; p = 0.15), while unstimulated 
   salivary flow showed a significant benefit (MD: 0.13; 95% CI: 0.09 to 0.17; 
   p < 0.00001). A significant reduction in the severity of oral pain was also noted 
   (MD: -2.25; p < 0.0001). No significant differences were found for the incidence 
   or duration of mucositis, dysphagia, or fatigue. Considerable heterogeneity was 
   observed across the studies and no single intervention demonstrated consistent 
   efficacy in managing radiation-induced xerostomia. Some therapies have shown 
   promise in improving unstimulated salivary flow and reducing oral pain; however, 
   the overall evidence remains inconclusive. To address this persistent clinical 
   challenge, future trials should adopt standardised outcome measures, assess 
   combination therapies, and investigate novel regenerative strategies.
C1 Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. 
   Dow University of Health Sciences, Karachi, Pakistan.
   Dow University of Health Sciences, Karachi, Pakistan.
   Dow University of Health Sciences, Karachi, Pakistan.
   Faculty of Medicine, Al-Quds University, Jerusalem, Palestine.
   Faculty of Medicine, Al-Quds University, Jerusalem, Palestine.
   Faculty of Medicine, Al-Quds University, Jerusalem, Palestine.
   Basildon University Hospital, Basildon, United Kingdom.
   University Hospitals of Leicester, Leicester, United Kingdom.
   University Hospitals of Leicester, Leicester, United Kingdom
   University of Leicester, Leicester, United Kingdom
   University of Derby, Derby, United Kingdom.
EM oadi.nawaf97@gmail.com
NR 0
TC 0
SN 1532-194
EI 
J9 Br J Oral Maxillofac Surg
PD NOV 19
PY 2025
VL 0
IS 
BP 
EP 
DI 10.1016/j.bjoms.2025.10.003 
PG 0
UT PubMed:41253620
PM 41253620
DA 2025-11-19
ER

PT J
AU Zeng, J
   Lu, Y
   Chu, H
   Lu, L
   Chen, Y
   Ji, K
   Lin, Y
   Li, J
   Wang, S
AF Zeng, Jingchun
   Lu, Yiqian
   Chu, Hui
   Lu, Liming
   Chen, Yuexuan
   Ji, Kaisong
   Lin, Yeze
   Li, Jingjing
   Wang, Shuxin
TI Research trends and frontier hotspots of TRPV1 based on bibliometric and 
SO Heliyon
LA English
DT Review
DE Bibliometrics; CiteSpace; Research hotspots; TRPV1; Visualization analyses
AB BACKGROUND: Transient receptor potential vanilloid type1 (TRPV1) is a 
   non-selective cation channel with multiple activation mechanisms, which has 
   received increasing attention since it was first cloned in 1997. METHODS: We used 
   bibliometric and visualization analyses to evaluate the theme trends and 
   knowledge structure of TRPV1 research-papers on TRPV1 from 2002 to 2022 obtained 
   from the Web of Science Core Collection. VOSviewer and CiteSpace were used to 
   analyze authors, institutions, countries, co-cited references, and keywords. 
   RESULTS: A total of 7413 papers were included. The main research area of TRPV1 
   was neuroscience; the most published country was the United States, and the 
   University of California, San Francisco, had the highest centrality. Two major 
   collaborative sub-networks were formed between the authors. The distribution of 
   keywords shows that TRPV1 was initially studied extensively, and the recent 
   studies focused on TRPV1 structure and diseases. "Oxidative stress," "TRPV1 
   structure," "cancer," and "model" have been the research hotspots in recent 
   years. CONCLUSIONS: This research provides valuable information for the study of 
   TRPV1. Disease research was focused on pain, cancer, and neurodegenerative 
   diseases. Both agonists and antagonists of TRPV1 are gradually being used in 
   clinical practice, and acupuncture was effective in treating TRPV1-mediated 
   inflammatory pain. TRPV1 is involved in classical endogenous cannabis system 
   signaling, and new signaling pathways continue to be revealed.
C1 Rehabilitation Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Clinical Research and Data Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, GuangzhouUniversity of Chinese Medicine, Guangzhou, Guangdong, China.
   The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Rehabilitation Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
   Bao'an Traditional Chinese Medicine Hospital//Seventh Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Shenzhen, Guangdong, China.
   Rehabilitation Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
NR 0
TC 0
SN 2405-844
EI 2405-844
J9 Heliyon
PD JAN 31
PY 2024
VL 10
IS 2
BP e24153
EP e24153
DI 10.1016/j.heliyon.2024.e24153 
PG 1
UT PubMed:38293347
PM 38293347
DA 2024-01-31
ER

PT J
AU Cheon, S
   Zhang, X
   Lee, IS
   Cho, SH
   Chae, Y
   Lee, H
AF Cheon, Soyeon
   Zhang, Xiuyu
   Lee, In-Seon
   Cho, Seung-Hun
   Chae, Younbyoung
   Lee, Hyangsook
TI Pharmacopuncture for cancer care: a systematic review.
SO Evidence-based complementary and alternative medicine : eCAM
LA English
DT Review
AB Background. Pharmacopuncture, injection to acupoints with pharmacological 
   medication or herbal medicine, is a new acupuncture therapy widely available in 
   Korea and China for cancer-related symptoms. However, the evidence is yet to be 
   clear. Objective. To determine pharmacopuncture's effectiveness on cancer-related 
   symptoms. Methods. Eleven databases were searched for randomized controlled 
   trials of pharmacopuncture in cancer patients. The Cochrane risk of bias (ROB) 
   assessment tool was used for quality assessment. Results. Twenty-two studies 
   involving 2,459 patients were included. Five trials of chemotherapy-induced 
   nausea and vomiting (CINV) underwent meta-analysis. Pharmacopuncture 
   significantly relieved severity of CINV compared with control group (3 trials, 
   risk ratio (RR) 1.28, 95% confidence interval (CI) = 1.14-1.44). The frequency of 
   CINV was also significantly reduced with pharmacopuncture (2 trials, RR 2.47, 95% 
   CI = 2.12-2.89). Seventeen trials studied various symptoms, and in most studies, 
   pharmacopuncture significantly relieved pain, ileus, hiccup, fever, and 
   gastrointestinal symptoms and improved quality of life in various cancer 
   patients. ROB was generally high. Conclusion. It may be suggested with caution 
   that pharmacopuncture may help various symptom relief in cancer patients, but it 
   is hard to draw a firm conclusion due to clinical heterogeneity and high ROB of 
   the included studies, hence warranting further investigation.
C1 Department of Korean Medical Science, Graduate School, Kyung Hee University, Kyung Hee Dae-ro 26, Dongdaemun-gu, Seoul 130-701, Republic of Korea ;Acupuncture and Meridian Science Research Center, College of Korean Medicine,Kyung Hee University, Kyung Hee Dae-ro 26, Dongdaemun-gu, Seoul 130-701, Republicof Korea.
   Department of Korean Medical Science, Graduate School, Kyung Hee University, Kyung Hee Dae-ro 26, Dongdaemun-gu, Seoul 130-701, Republic of Korea ;Acupuncture and Meridian Science Research Center, College of Korean Medicine,Kyung Hee University, Kyung Hee Dae-ro 26, Dongdaemun-gu, Seoul 130-701, Republicof Korea.
   Department of Korean Medical Science, Graduate School, Kyung Hee University, Kyung Hee Dae-ro 26, Dongdaemun-gu, Seoul 130-701, Republic of Korea ;Acupuncture and Meridian Science Research Center, College of Korean Medicine,Kyung Hee University, Kyung Hee Dae-ro 26, Dongdaemun-gu, Seoul 130-701, Republicof Korea.
   Hospital of Korean Medicine, Kyung Hee University Medical Center, Kyung Hee Dae-ro 23, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
   Department of Korean Medical Science, Graduate School, Kyung Hee University, Kyung Hee Dae-ro 26, Dongdaemun-gu, Seoul 130-701, Republic of Korea ;Acupuncture and Meridian Science Research Center, College of Korean Medicine,Kyung Hee University, Kyung Hee Dae-ro 26, Dongdaemun-gu, Seoul 130-701, Republicof Korea.
   Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Kyung Hee Dae-ro 26, Dongdaemun-gu, Seoul 130-701, Republicof Korea.
NR 0
TC 0
SN 1741-428
EI 1741-427
J9 Evid Based Complement Alternat Med
PD JUN 6
PY 2014
VL 2014
IS 
BP 804746
EP 804746
DI 10.1155/2014/804746 
PG 0
UT PubMed:24899911
PM 24899911
DA 2014-06-06
ER

PT J
AU Xu, Y
   Chen, Y
   Feng, Y
   Zhang, Q
   Zhou, T
   Wo, C
   Zhang, M
AF Xu, Yun
   Chen, Yunting
   Feng, Yongfu
   Zhang, Qian
   Zhou, Tao
   Wo, Chunxin
   Zhang, Minmin
TI Silver needle thermal conduction therapy relieves pain in rats with myofascial 
SO American journal of translational research
LA English
DT Journal Article
DE Myofascial pain syndrome; acupuncture effect; chronic pain; silver needle thermal conduction therapy; thermal effect
AB OBJECTIVE: To assess the effects of silver needle thermal conduction therapy on 
   spinal neurotransmitter activation and inflammation reduction in the myofascial 
   trigger point musculature of a rat model with myofascial pain syndrome (MPS). 
   METHODS: The MPS rat model was induced by a combination of impact and exercise 
   fatigue. MPS rats were then subjected to silver needle thermal conduction therapy 
   for 14 days. Thermal and mechanical pain thresholds were assessed using the 
   thermal hyperalgesia and mechanical hyperalgesia tests. Transverse and 
   longitudinal sections of the right medial thigh muscle were prepared for 
   histological analysis using HE staining. Western blot and immunohistochemistry 
   were used to measure the expression of calcitonin gene-related peptide (CGRP), 
   substance P (SP), and 5-hydroxytryptamine (5-HT) in the L4-6 segment of the 
   spinal cord. Additionally, the levels of inflammatory cytokines, including 
   interleukin 1-β (IL-1β) and tumor necrosis factor α (TNF-α), in the right medial 
   femoral muscle were assessed via ELISA. RESULTS: MPS rats exhibited a decreased 
   thermal and mechanical pain threshold compared to control rats. Muscle fiber 
   atrophy and deformation were observed in the MPS rats. Levels of IL-1β and TNF-α 
   were elevated in the right medial femoral muscle, while CGRP and SP expression 
   were increased, and 5-HT expression was decreased in the spinal cord. Silver 
   needle thermal conduction therapy effectively reversed these pathological changes 
   in the MPS rats. CONCLUSIONS: Silver needle thermal conduction therapy alleviated 
   MPS in rats by modulating spinal neurotransmitter expression and reducing muscle 
   inflammation.
C1 Department of Pain, The Second Affiliated Hospital of Guizhou Medical University Kaili 556000, Guizhou, China.
   Department of Pain, Affiliated Hospital of Guizhou Medical University Guiyang 550004, Guizhou, China.
   Department of Pain, The Second Affiliated Hospital of Guizhou Medical University Kaili 556000, Guizhou, China.
   Department of Pain, The Second Affiliated Hospital of Guizhou Medical University Kaili 556000, Guizhou, China.
   Department of Pain, The Second Affiliated Hospital of Guizhou Medical University Kaili 556000, Guizhou, China.
   Department of Pain, Affiliated Hospital of Guizhou Medical University Guiyang 550004, Guizhou, China.
   Department of Pain, Affiliated Hospital of Guizhou Medical University Guiyang 550004, Guizhou, China.
NR 0
TC 0
SN 1943-814
EI 1943-814
J9 Am J Transl Res
PD MAY 19
PY 2025
VL 17
IS 4
BP 2604
EP 2613
DI 10.62347/QQBB3856 
PG 9
UT PubMed:40385020
PM 40385020
DA 2025-05-19
ER

PT J
AU Liu, W
   Zhang, Y
   Zhu, Q
   Wu, L
AF Liu, Wei
   Zhang, Ying
   Zhu, Qi
   Wu, Lan
TI A scientometric study on research trends and characteristics of burning mouth 
SO Journal of dental sciences
LA English
DT Journal Article
DE Bibliometrics; Burning mouth syndrome; Neurological factors; Psychological factors; Therapy strategy
AB BACKGROUND/PURPOSE: Burning mouth syndrome (BMS) is a chronic condition 
   characterized by intraoral burning sensation and orofacial pain but without oral 
   mucosal lesions. The purpose of this study was to analyze the scientometric 
   characteristics and research trends of BMS. MATERIALS AND METHODS: All the papers 
   on BMS were comprehensively retrieved from the Scopus database. The years of 
   publication were divided into before 2015 and 2015-2024 in the analysis of 
   research trends. RESULTS: There were 924 papers on BMS, with total citations of 
   24,024 and the h index of 76. The related disorders of BMS were depression, 
   xerostomia, pain, anxiety, glossodynia, taste disorder, nociception, paresthesia, 
   analgesia, sleep disorder, diabetes mellitus, and neuralgia. Clonazepam was most 
   common pharmacotherapy for BMS. After 2015, pharmacologic keywords including drug 
   safety, aripiprazole, duloxetine, folic acid, hydrocortisone, and pregabalin were 
   more frequent. Low level laser therapy, acupuncture, and cognitive behavioral 
   therapy were the emerging nonpharmacologic strategies for BMS. Moreover, 
   laboratory investigations on biomarkers, blood, genetics, interleukin 6, and 
   tumor necrosis factor were more common. Various questionnaires, comorbidity, 
   complication, anemia, hypertension, diabetes mellitus, and sleep were also more 
   concerned after 2015. CONCLUSION: This scientometric study elucidated the current 
   scenario and research trends of BMS, and would help in improving in reciprocal 
   collaboration and communication for investigations on this condition.
C1 Department of Stomatology, Fengcheng Hospital of Fengxian District, Shanghai Ninth People's Hospital Fengcheng Branch Hospital, Shanghai, China.
   Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth 
   College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai KeyLaboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai,China.
   College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai KeyLaboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai,China.
   Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai 
   Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai,China.
   College of Stomatology, Shanghai Jiao Tong University, National Center for 
   College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai KeyLaboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai,China.
   Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai 
NR 0
TC 0
SN 2213-886
EI 1991-790
J9 J Dent Sci
PD APR 14
PY 2025
VL 20
IS 2
BP 1252
EP 1256
DI 10.1016/j.jds.2025.01.009 
PG 4
UT PubMed:40224121
PM 40224121
DA 2025-04-14
ER

PT J
AU Al-Ajlouni, YA
   Al, Ta'ani O
   Zweig, SA
   Bak, M
   Tanashat, M
   Gabr, A
   Khamis, Z
   Al-Bitar, F
   Islam, M
AF Al-Ajlouni, Yazan A
   Al Ta'ani, Omar
   Zweig, Sophia A
   Bak, Magdalena
   Tanashat, Mohammad
   Gabr, Ahmed
   Khamis, Zaid
   Al-Bitar, Farah
   Islam, Mohammad
TI Assessing the Therapeutic Role of Rehabilitation Programs in Chemotherapy-Induced 
SO Healthcare (Basel, Switzerland)
LA English
DT Review
DE chemotherapy-induced peripheral neuropathy; neuropathic symptoms; pain management; rehabilitation programs; scoping review
AB Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, 
   debilitating side effect of cancer treatment. Characterized by symptoms like 
   pain, numbness, and muscle weakness, CIPN significantly impacts patients' quality 
   of life. Current management strategies vary, with limited consensus on effective 
   treatments. This scoping review aims to explore comprehensive rehabilitation 
   interventions for CIPN, focusing on enhancing patient well-being and functional 
   abilities. Methods: A scoping review, guided by Arksey and O'Malley's framework 
   and Levac et al.'s refinements, was conducted to assess rehabilitation programs 
   for CIPN. Searches across six databases were performed, with inclusion and 
   exclusion criteria focusing on studies with physical rehabilitation 
   interventions. Data were charted, detailing interventions, demographics, and 
   outcomes. Results were synthesized descriptively and presented narratively with 
   tables. Results: The review included 24 studies covering diverse cancer types and 
   treatments, involving a total of 1167 participants. Various interventions for 
   CIPN were assessed, and results were thematically categorized according to 
   exercise category. Physical modalities like ultrasound and exercise showed 
   promise in symptom relief for colorectal and breast cancer patients. No distinct 
   advantage was found in the timing of exercise interventions. Complementary 
   therapies such as acupuncture and yoga demonstrated effectiveness in managing 
   CIPN symptoms. Conclusions: This review highlights the effectiveness of diverse 
   physical and complementary interventions in managing CIPN, advocating for their 
   integration into standard protocols. It emphasizes the need for holistic, 
   patient-centered approaches that combine exercises, physical therapy, and 
   complementary therapies to improve patient outcomes. These findings set a 
   direction for future research and clinical practices focused on comprehensive and 
   personalized CIPN management strategies.
C1 School of Medicine, New York Medical College, Valhalla, NY 10595, USA.
   Department of Physical Medicine and Rehabilitation, Metropolitan Hospital, New 
   Department of Medicine, Staten Island University Hospital, Staten Island, NY 10305, USA.
   Alleghany Health Network, Pittsburgh, PA 15212, USA.
   School of Medicine, SUNY Downstate College of Medicine, Brooklyn, NY 11203, USA.
   School of Sciences, New York University Abu Dhabi (NYUAD), Abu Dhabi P.O. Box 129188, United Arab Emirates.
   Faculty of Medicine, Yarmouk University, Irbid 21163, Jordan.
   School of Medicine, New York Medical College, Valhalla, NY 10595, USA.
   Department of Medicine, Staten Island University Hospital, Staten Island, NY 10305, USA.
   Homer Stryker M.D. School of Medicine, Western Michigan University, Kalamazoo, MI 49007, USA.
   Department of Physical Medicine and Rehabilitation, Metropolitan Hospital, New York, NY 10029, USA.
NR 0
TC 0
SN 2227-903
EI 2227-903
J9 Healthcare (Basel)
PD JUL 13
PY 2025
VL 13
IS 13
BP 
EP 
DI 10.3390/healthcare13131526 
PG 0
UT PubMed:40648551
PM 40648551
DA 2025-07-13
ER

PT J
AU Hoang, BX
   Han, BO
   Tran, HQ
   Fang, WH
   Tran, HD
AF Hoang, Ba X
   Han, B O
   Tran, Hung Q
   Fang, William H
   Tran, Hau D
TI Successful Phytotherapy for Acute Refractory Radiation Cystitis in a Cervical 
SO Cancer diagnosis & prognosis
LA English
DT Journal Article
DE Ich Nieu Khang; Radiation cystitis; cervical cancer; food supplements; phytotherapy
AB BACKGROUND/AIM: Radiation cystitis is a frequent complication that can occur 
   after therapeutic irradiation of pelvic cancers. The current treatment for this 
   condition is complex and often ineffective. CASE REPORT: We present a clinical 
   case of a 54-year-old patient diagnosed with small cell cervical cancer FIGO 
   stage IIIC who developed grade 2-3 radiation cystitis following post-operational 
   chemoradiation therapy. The patient exhibited increased urinary urgency and 
   frequency, dysuria, and low abdominal pain, which failed to respond to 
   acupuncture and corticosteroid treatments. A course of Ich Nieu Khang 
   phytotherapy tablets, resulted in significant improvement of symptoms within 24 
   hours of initiation. The symptoms resolved completely within 10 days, and 
   ultrasonography documented a marked decrease in bladder wall thickening and 
   improved bladder evacuation function. The phytotherapy was well-tolerated, and no 
   side-effects were observed during the 60-day treatment period. CONCLUSION: These 
   findings suggest that phytotherapy may be viable for managing radiation cystitis. 
   However, further controlled clinical trials are needed to confirm the efficacy of 
   Ich Nieu Khang and promote its broader clinical applications.
C1 Nimni-Cordoba Tissue Engineering and Drug Discovery Laboratory, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles,CA, U.S.A.
   Nimni-Cordoba Tissue Engineering and Drug Discovery Laboratory, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles,CA, U.S.A.
   Department of Oncology, Phenikaa University, Hanoi, Vietnam.
   Department of Translational Research, Western University of Health Sciences, Pomona, CA, U.S.A.
   Department of Oncology, National Children Hospital of Vietnam, Hanoi, Vietnam.
NR 0
TC 0
SN 2732-778
EI 
J9 Cancer Diagn Progn
PD MAY 12
PY 2023
VL 3
IS 3
BP 383
EP 386
DI 10.21873/cdp.10228 
PG 3
UT PubMed:37168975
PM 37168975
DA 2023-05-12
ER

PT J
AU Wu, MM
   Liu, XH
   Wang, LJ
   Chen, XY
   Li, YX
AF Wu, Min-Min
   Liu, Xiao-Hua
   Wang, Li-Jiao
   Chen, Xiao-Yu
   Li, Ya-Xue
TI [Clinical observation on deep needling at Xiaguan (ST 7) with round sharp needle 
SO Zhongguo zhen jiu = Chinese acupuncture & moxibustion
LA chi
DT Journal Article
DE Point ST 7 (Xiaguan); inflammatory cytokine; plum-blossom needle; round sharp needle; trigeminal neuralgia
AB OBJECTIVE: To compare the clinical therapeutic effect between deep needling at 
   Xiaguan (ST 7) with round sharp needle combined with plum-blossom needle and 
   conventional acupuncture in patients with trigeminal neuralgia (TN) of wind and 
   heat, and explore its mechanism. METHODS: A total of 60 patients with TN of wind 
   and heat were randomized into an observation group (30 cases) and a control group 
   (30 cases). In the observation group, deep needling with round sharp needle was 
   applied at Xiaguan (ST 7), and tapping with plum-blossom needle was applied at 
   Yangbai (GB 14), Quanliao (SI 18), Dicang (ST 4), Sibai (ST 2), etc. of affected 
   side. In the control group, conventional acupuncture was applied at the same 
   acupoints selected in the observation group. The treatment was given once a day, 
   5 times a week for 4 weeks in the both groups. Before and after treatment, the 
   scores of short-form McGill pain questionnaire (SF-MPQ), TCM syndrome, patient 
   global impression of change (PGIC) and comprehensive symptom were observed, the 
   serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), vasoactive 
   intestinal peptide (VIP) and β-endorphin (β-EP) were detected, and the adverse 
   reaction was observed in the both groups. RESULTS: After treatment, the scores of 
   PRI, PPI, VAS, TCM syndrome, PGIC and comprehensive symptom and the serum levels 
   of IL-6, TNF-α and VIP were decreased compared before treatment in the both 
   groups (P<0.05), and the variations of above indexes in the observation group 
   were larger than those in the control group (P<0.05). After treatment, the serum 
   levels of β-EP were increased compared before treatment in the both groups 
   (P<0.05), and the variation of that in the observation group was larger than the 
   control group (P<0.05). No severe adverse reaction was observed in the both 
   groups. CONCLUSION: Deep needling at Xiaguan (ST 7) with round sharp needle 
   combined with plum-blossom needle can effectively treat the trigeminal neuralgia 
   of wind and heat and relieve pain, its therapeutic effect is superior to 
   conventional acupuncture. The mechanism may be related to the regulation of serum 
   IL-6, TNF-α, VIP and β-EP.
C1 Graduate School of Heilongjiang University of CM, Harbin 150040, China.
   Graduate School of Heilongjiang University of CM, Harbin 150040, China.
   Graduate School of Heilongjiang University of CM, Harbin 150040, China.
   Graduate School of Heilongjiang University of CM, Harbin 150040, China.
   Department of Acupuncture and Moxibustion, First Affiliated Hospital of Heilongjiang University of CM, Harbin 150040.
NR 0
TC 0
SN 
EI 0255-293
J9 Zhongguo Zhen Jiu
PD OCT 11
PY 2021
VL 41
IS 10
BP 1089
EP 94
DI 10.13703/j.0255-2930.20210318-0003 
PG -995
WC Flowers; Hot Temperature; Humans; Prunus domestica; Trigeminal Neuralgia; therapy; Wind
UT PubMed:34628740
PM 34628740
DA 2021-10-11
ER

PT J
AU Jazebi, N
   Evans, C
   Kadaru, HS
   Kompella, D
   Raji, M
   Fang, F
   Pappolla, M
   Tang, SJ
   Chung, JM
   Hammock, B
   Fang, X
AF Jazebi, Noushin
   Evans, Chad
   Kadaru, Hima S
   Kompella, Divya
   Raji, Mukaila
   Fang, Felix
   Pappolla, Miguel
   Tang, Shao-Jun
   Chung, Jin Mo
   Hammock, Bruce
   Fang, Xiang
TI HIV-related Neuropathy: Pathophysiology, Treatment and Challenges.
SO Journal of neurology and experimental neuroscience
LA English
DT Journal Article
DE HIV; neuropathy; pain; pathophysiology; treatment
AB HIV-sensory neuropathy (HIV-SN) is a debilitating complication in HIV patients 
   with or without anti-retroviral treatment (ART). Common symptoms of HIV-SN 
   include pain, decreased sensation, paresthesias, and dysesthesias in a symmetric 
   stocking-glove distribution. While HIV-1 protein such as gp120 is implicated in 
   HIV-SN (e.g. impaired large-diameter fiber), ART itself was recently shown to 
   contribute to HIV-SN in HIV patients and impair thin fiber. Multiple host 
   mechanisms may play roles during the pathogenesis of HIV-SN, including 
   neuron-glia interactions in the spinal dorsal horn (SDH), inflammation, 
   mitochondrial dysfunction and endoplasmic reticulum stress. Concurrent 
   infections, such as tuberculosis, also carry a higher likelihood of HIV-SN as 
   well as environmental or genetic predisposition. Pro-inflammatory cytokines such 
   as IL-1, IL2 receptor-alpha, and tumor necrosis factor (TNF) along with abnormal 
   lactate levels have been identified as potential players within the complex 
   pathophysiology of this condition. In this paper, we review the pathophysiology 
   of HIV neuropathy, focusing on the various treatment options available or under 
   investigation. Although several treatment options are available e.g., the 
   capsaicin patch and spinal cord stimulation, symptomatic control of HIV-SN are 
   often challenging. Alternative approaches such as self-hypnosis, resistance 
   exercise, cannabinoids, and acupuncture have all shown promising results, but 
   need further investigation.
C1 Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.
   Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.
   Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.
   Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.
   Department of Medicine, University of Texas Medical Branch, Galveston, TX 77555.
   Department of Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, TX 77555.
   Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.
   Department of Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, TX 77555.
   Department of Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, TX 77555.
   Department of Entomology and Nematology & Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA.
   Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.
NR 0
TC 0
SN 2469-407
EI 2469-407
J9 J Neurol Exp Neurosci
PD JAN 1
PY 2021
VL 7
IS 1
BP 15
EP 24
DI 10.17756/jnen.2021-082 
PG 9
UT PubMed:35252633
PM 35252633
DA 2021-01-01
ER

PT J
AU Pan, WT
   Ji, MH
   Ma, D
   Yang, JJ
AF Pan, Wei-Tong
   Ji, Mu-Huo
   Ma, Daqing
   Yang, Jian-Jun
TI Effect of perioperative autonomic nervous system imbalance on surgical outcomes: 
SO British journal of anaesthesia
LA English
DT Journal Article
DE autonomic nervous system; parasympathetic tone; perioperative autonomic imbalance; perioperative outcomes; vagus nerve stimulation
AB The autonomic nervous system (ANS) is essential for maintaining physiological 
   homeostasis. Autonomic nervous system imbalance, characterised by sympathetic 
   hyperactivation and low parasympathetic tone, can occur during the perioperative 
   period. These changes drive systemic stress responses, cardiovascular 
   instability, impaired tissue repair, and immunosuppression, which in turn 
   increase infection risk, neurocognitive decline, and multiorgan dysfunction. 
   Surgical trauma, anaesthesia, pain, hypothermia, and psychological stressors all 
   contribute to this dysregulation, and consequently low parasympathetic tone 
   results in the cholinergic anti-inflammatory pathway being less effective. High 
   sympathetic nervous system activity promotes catecholamine surges and 
   pro-inflammatory cytokine release. Pharmacological interventions, including 
   dexmedetomidine and β-blockers, together with nonpharmacological strategies, such 
   as electroacupuncture and temperature management, are measures that have 
   potential to restore ANS balance. This systematic review covers ANS-mediated 
   organ regulation, pathophysiological consequences of perioperative dysautonomia, 
   and evidence-based therapeutic strategies. By integrating findings from multiple 
   basic and clinical studies, the pivotal roles of ANS modulation in mitigating 
   postoperative complications, including neurocognitive disorders, 
   immunosuppression, and cancer recurrence, are discussed. Maintaining balance of 
   the sympathetic and parasympathetic nervous systems is an important prospect in 
   perioperative medicine that could benefit surgical patients' short- or long-term 
   recovery.
C1 Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China;Neuroscience Research Institute, Zhengzhou University Academy of MedicalSciences, Zhengzhou, Henan, China.
   Department of Anesthesiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
   Perioperative and Systems Medicine Laboratory and Department of Anesthesiology, Children's Hospital, Zhejiang University School of Medicine, National ClinicalResearch Center for Child Health, Hangzhou, Zhejiang, China
   Department ofAnesthesiology, The First Affiliated Hospital, Ningbo University, Ningbo,Zhejiang, China
   Division of Anaesthetics, Pain Medicine & Intensive Care,Department of Surgery & Cancer, Faculty of Medicine, Imperial College London,Chelsea & Westminster Hospital, London, UK. 
   Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China;Neuroscience Research Institute, Zhengzhou University Academy of MedicalSciences, Zhengzhou, Henan, China. 
EM yjyangjj@126.com
NR 0
TC 0
SN 1471-677
EI 0007-091
J9 Br J Anaesth
PD JUL 5
PY 2025
VL 135
IS 3
BP 608
EP 622
DI 10.1016/j.bja.2025.06.004 
PG 14
WC Humans; Autonomic Nervous System; physiopathology; Postoperative Complications; physiopathology; Perioperative Care; methods; Autonomic Nervous System Diseases; physiopathology; Treatment Outcome
UT PubMed:40615330
PM 40615330
DA 2025-07-05
ER

PT J
AU Li, D
   Wu, Y
   Chang, L
   Song, Y
   Du, X
   Xue, F
   Liu, Y
   Wu, J
   Wang, T
AF Li, Daxian
   Wu, Yan
   Chang, Lirong
   Song, Yizhi
   Du, Xiaoqiang
   Xue, Fenqin
   Liu, Yang
   Wu, Jie
   Wang, Tianlong
TI Therapeutic effects of melittin on paclitaxel-induced peripheral neuropathic pain 
SO Frontiers in neuroscience
LA English
DT Journal Article
DE acupuncture; analgesia; bee venom; chemotherapy-induced peripheral neuropathy; electrophysiological recording; noradrenergic system; wide dynamic range neuron
AB INTRODUCTION: As a taxane-based cytostatic agent, paclitaxel holds a broad 
   spectrum of life-saving properties. However, its use is frequently limited by 
   painful neuropathy in the extremities, which severely hinders the ultimate 
   prognosis of cancer survivors. While bee venom therapy has shown promise in 
   alleviating chemotherapy-induced neuropathic pain, the analgesic potential of its 
   primary bioactive components, such as melittin and phospholipase A2 (bvPLA2), 
   remains uncharacterized. This study investigated the ameliorative effects of 
   melittin against paclitaxel-induced peripheral neuropathy in rats through 
   integrated behavioral, in vivo electrophysiological, and neuropharmacological 
   approaches. METHODS: Paclitaxel was administered intraperitoneally (i.p.) at a 
   total dose of 8 mg/kg. Cold and mechanical allodynia and hyperalgesia were 
   quantified using the acetone drop and von Frey filament tests. To compare the 
   therapeutic properties of bee venom ingredients, either melittin (0.5 mg/kg) or 
   bvPLA2 (0.12 mg/kg) was administered subcutaneously at ST36 (Zusanli acupoint). 
   In vivo extracellular recordings of wide dynamic range (WDR) neurons were 
   performed in the spinal dorsal horn. Noradrenaline depletion was induced by the 
   i.p. treatment with N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4, 50 
   mg/kg), and serotonin depletion was conducted by the i.p. administration of 
   para-chlorophenylalanine (PCPA, 450 mg/kg). RESULTS: ST36 treatment with 
   melittin, but not bvPLA2, markedly impeded mechanical and cold hypersensitivity. 
   Electrophysiological analysis revealed that paclitaxel induced spontaneous and 
   stimulus-evoked hyperexcitation of spinal WDR neurons. Melittin selectively 
   suppressed evoked neuronal activities (i.e., acute responses and 
   after-discharges) without modulating the spontaneous firing of WDR neurons. 
   Neuropharmacological investigation demonstrated that the effects of melittin were 
   fully reversed by noradrenaline depletion, whereas serotonin depletion had no 
   effect. DISCUSSION: Our findings establish that melittin treatment at ST36 could 
   ease paclitaxel-induced neuropathic pain by partially attenuating the 
   hyperexcitable state of spinal WDR neurons. Furthermore, these ameliorative 
   actions were mediated by the specific recruitment of the endogenous noradrenergic 
   system. This study provides novel evidence supporting melittin as a targeted 
   symptomatic agent for paclitaxel-induced peripheral neuropathy, which would 
   advance the development of promising analgesic strategies in oncological care.
C1 Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
   National Clinical Research Center for Geriatric Diseases, Beijing, China.
   Beijing Key Laboratory of Neural Regeneration and Repair, Department of Anatomy, School of Basic Medical Sciences, Beijing Institute of Brain Disorders, CapitalMedical University, Beijing, China.
   College of Veterinary Medicine, Beijing University of Agriculture, Beijing, 
   Beijing Key Laboratory of Neural Regeneration and Repair, Department of Anatomy, School of Basic Medical Sciences, Beijing Institute of Brain Disorders, CapitalMedical University, Beijing, China.
   Beijing Key Laboratory of Neural Regeneration and Repair, Department of Anatomy, School of Basic Medical Sciences, Beijing Institute of Brain Disorders, CapitalMedical University, Beijing, China.
   Beijing Key Laboratory of Neural Regeneration and Repair, Department of Anatomy, School of Basic Medical Sciences, Beijing Institute of Brain Disorders, CapitalMedical University, Beijing, China.
   Core Facilities Center, Capital Medical University, Beijing, China.
   Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
   National Clinical Research Center for Geriatric Diseases, Beijing, China.
   Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
   National Clinical Research Center for Geriatric Diseases, Beijing, China.
   Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
   National Clinical Research Center for Geriatric Diseases, Beijing, China.
NR 0
TC 0
SN 1662-453
EI 1662-454
J9 Front Neurosci
PD JUL 17
PY 2025
VL 19
IS 
BP 1622553
EP 1622553
DI 10.3389/fnins.2025.1622553 
PG 0
UT PubMed:40672870
PM 40672870
DA 2025-07-17
ER

PT J
AU Ye, AL
   Abdi, S
AF Ye, Alice L
   Abdi, Salahadin
TI Beyond p-values: a cross-sectional umbrella review of chemotherapy-induced 
SO Frontiers in pain research (Lausanne, Switzerland)
LA English
DT Journal Article
DE chemotherapy-induced peripheral neuropathy; clinical research methodology; effect size analysis; p-values; randomized controlled trials; systematic reviews; umbrella review
AB INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side 
   effect of neurotoxic chemotherapy agents, significantly impacting the daily lives 
   of many cancer survivors. Despite thousands of articles published on CIPN, we 
   remain no closer to a successful treatment regimen for the condition. In recent 
   years, several new clinical trials and systematic reviews have been published, 
   many exploring nonpharmaceutical interventions, prompting the need for a 
   comprehensive synthesis of this emerging evidence. METHODS: We conducted an 
   umbrella review to identify and appraise the 19 systematic reviews (SRs) 
   published in 2023 that examined randomized controlled trials (RCTs) for 
   established CIPN treatment. We focused our analysis on the three most researched 
   treatment options: oral drugs, exercise, and acupuncture. RCTs not previously 
   synthesized together were reviewed, and effect size analyses were performed to 
   allow readers to interpret the existing literature beyond binary p-values. 
   RESULTS: Our analysis of RCTs revealed the following key findings. For cancer 
   survivors with CIPN after completing chemotherapy, serotonin-norepinephrine 
   reuptake inhibitors (SNRIs) as well as acupuncture provided at least short-term 
   relief for pain and sensory symptoms. For patients with CIPN who were actively 
   undergoing chemotherapy, home-based balance and strength training exercises 
   appeared to alleviate symptoms. Effect size analyses highlighted variability in 
   treatment responses, underscoring the limitations of relying solely on p-values 
   to assess intervention efficacy. DISCUSSION: Through an umbrella review approach, 
   we demonstrate that SRs are often less systematic than expected. None of the 19 
   SRs captured all relevant RCTs within their search timeframe. However, by 
   cross-referencing SRs, we identified 41 RCTs across 42 publications, illustrating 
   the feasibility of an umbrella review approach to uncover relevant trials. 
   Furthermore, many SRs exhibited methodological concerns that limit the 
   interpretability of their findings. Finally, we discuss multiple opportunities 
   for refining methods and reporting in future CIPN treatment trials. SYSTEMATIC 
   REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024508283, 
   PROSPERO (42024508283).
C1 Department of Pain Medicine, The University of Texas MD Anderson Texas Center, Houston, TX, United States.
   Department of Pain Medicine, The University of Texas MD Anderson Texas Center, Houston, TX, United States.
NR 0
TC 0
SN 2673-561
EI 2673-561
J9 Front Pain Res (Lausanne)
PD APR 3
PY 2025
VL 6
IS 
BP 1564662
EP 1564662
DI 10.3389/fpain.2025.1564662 
PG 0
UT PubMed:40176845
PM 40176845
DA 2025-04-03
ER

PT J
AU Romeiser, JL
   Chen, Z
   Nanavati, K
   Williams, AA
AF Romeiser, Jamie L
   Chen, Zhi
   Nanavati, Kaushal
   Williams, Augusta A
TI Correlates and patterns of using complementary health approaches among 
SO Journal of cancer survivorship : research and practice
LA English
DT Journal Article
DE Cancer; Complementary and integrative health; Complementary health approaches; Complementary therapies; Integrative medicine; Mind and body therapies; Prevalence; Survivorship
AB PURPOSE: To (1) describe and compare the prevalence of using of complementary 
   health approaches, focusing on mind and body practices, and reasons for use among 
   cancer survivors, and (2) examine characteristics associated with use among those 
   with a recent and non-recent diagnosis of cancer compared to those without a 
   previous cancer diagnosis. METHODS: Using data from the 2022 US National Health 
   Interview Survey, prevalence estimates were derived for using any complementary 
   health approach, by category (manipulative body-based [chiropractor, acupuncture, 
   massage], creative [music therapy, art therapy], and mind-body [meditation, 
   guided imagery, yoga]), and reasons for use. Regression models identified 
   correlates of use among all participants and within cancer diagnosis subgroups. 
   RESULTS: Among 26,523 adult participants, overall prevalence of using any 
   complementary approach was similar amongst individuals with recent cancer 
   (40.17%), non-recent cancer (37.75%), and no cancer diagnosis (37.93%). However, 
   odds of use were higher amongst recent (OR = 1.37) and relatively long 
   term (OR = 1.14) cancer survivors compared to those without a history of cancer 
   in adjusted models (both p < 0.05). In cancer survivors, mind-body approaches 
   were mostly used for general health purposes, whereas manipulative approaches 
   were used for general health and pain management. Female sex, younger age, higher 
   education and income were among the prominent variables associated with using 
   complementary approaches. CONCLUSION: We present an important snapshot of the 
   landscape of using complementary approaches, specifically mind and body 
   practices, in adult cancer survivors in the US. Inequalities in access to these 
   therapies may exist, as use remains highest amongst those with higher 
   socioeconomic conditions. IMPLICATIONS FOR CANCER SURVIVORS: Given the prevalence 
   and potential benefits of complementary approaches among cancer survivors, there 
   is a need to better understand their effectiveness, optimal use, and integration 
   into cancer care. Further research is needed to understand and address access 
   barriers that might exist amongst some cancer survivors.
C1 Department of Public Health and Preventive Medicine, Upstate Medical University, Syracuse, NY, USA. RomeiseJ@upstate.edu.
   Department of Public Health and Preventive Medicine, Upstate Medical University, Syracuse, NY, USA.
   Upstate Cancer Center, Upstate Medical University, Syracuse, NY, USA.
   Department of Family Medicine, Upstate Medical University, Syracuse, NY, USA.
   Department of Public Health and Preventive Medicine, Upstate Medical University, Syracuse, NY, USA.
NR 0
TC 0
SN 1932-226
EI 
J9 J Cancer Surviv
PD SEP 9
PY 2024
VL 0
IS 
BP 
EP 
DI 10.1007/s11764-024-01665-5 
PG 0
UT PubMed:39249689
PM 39249689
DA 2024-09-09
ER

PT J
AU Abushukur, Y
   Cascardo, C
   Ibrahim, Y
   Teklehaimanot, F
   Knackstedt, R
AF Abushukur, Yasmine
   Cascardo, Camilla
   Ibrahim, Yousef
   Teklehaimanot, Fayven
   Knackstedt, Rebecca
TI Improving Breast Surgery Outcomes Through Alternative Therapy: A Systematic 
SO Cureus
LA English
DT Review
DE alternative medicine; breast; breast and endocrine surgery; breast cancer; complementary medicine; integrative medicine
AB Enhanced recovery after surgery (ERAS) protocols are the current standard of care 
   when it comes to improving post-surgical outcomes in breast cancer patients. 
   Compliance with all protocol items is required in order for patients to 
   experience significant benefits. Given that the ERAS protocols involve numerous 
   medications which each have unique side effect profiles and medication 
   interactions, this is often difficult to accomplish. Additionally, breast cancer 
   patients are often left with a large psychological burden, which ERAS protocols 
   fail to address. This review aims to determine the role that alternative 
   therapies can play in improving both the emotional and physical strains patients 
   experience during the post-operative stage of recovery. A PubMed search was 
   conducted using the following search terms ("alternative medicine" or 
   "complementary medicine" or "integrative medicine" or "holistic medicine" or 
   "natural medicine" or "mediation" or "aromatherapy" or "music" or "art" or 
   "reiki" or "massage") and ("surgery") and ("pain"). Studies selected for this 
   review include articles published or translated in English that addressed 
   alternative medical interventions affecting pre-, peri-, or post-operative 
   outcomes in breast biopsies, surgeries, or breast-related procedures. Eighteen 
   articles fit the inclusion criteria, with seven addressing music, five addressing 
   meditation, yoga, and guided imagery, five addressing massage, one addressing 
   myofascial release, four addressing aromatherapy, two addressing acupuncture, and 
   three addressing hypnosis. Most forms of alternative therapies offered some 
   benefit to patients following breast-related procedures, many resulting in 
   improvements in post-operative outcomes including pain, fatigue, energy, stress, 
   anxiety, mood, and depression. The reviewed studies demonstrated numerous 
   benefits to integrating alternative medicine into standardized therapy to improve 
   postoperative outcomes. Most studies analyzed did not include placebo controls as 
   including proper placebos was often not feasible. Future studies with larger 
   sample sizes are needed to better quantify the benefits patients receive from 
   these noninvasive, low-risk complementary therapies.
C1 Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, USA.
   Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, USA.
   Medicine, Oakland University William Beaumont School of Medicine, Roha, USA.
   Medicine, Michigan State University College of Osteopathic Medicine, Detroit, USA.
   Plastic Surgery, Cleveland Clinic, Cleveland, USA.
NR 0
TC 0
SN 2168-818
EI 2168-818
J9 Cureus
PD APR 29
PY 2022
VL 14
IS 3
BP e23443
EP e23443
DI 10.7759/cureus.23443 
PG 1
UT PubMed:35481320
PM 35481320
DA 2022-04-29
ER

PT J
AU Venkatasalu, MR
   Murang, ZR
   Ramasamy, DTR
   Dhaliwal, JS
AF Venkatasalu, Munikumar Ramasamy
   Murang, Zaidah Rizidah
   Ramasamy, Divya Thirumalai Rajam
   Dhaliwal, Jagjit Singh
TI Oral health problems among palliative and terminally ill patients: an integrated 
SO BMC oral health
LA English
DT Journal Article
DE Cancer; Integrated review; Oral conditions; Oral diseases; Palliative; Terminally-ill
AB BACKGROUND: High incidence of treatable oral conditions has been reported among 
   palliative patients. However, a large proportion of palliative patients lose 
   their ability to communicate their sufferings. Therefore, it may lead to 
   under-reporting of oral conditions among these patients. This review 
   systematically synthesized the published evidence on the presence of oral 
   conditions among palliative patients, the impact, management, and challenges in 
   treating these conditions. METHODS: An integrative review was undertaken with 
   defined search strategy from five databases and manual search through key 
   journals and reference list. Studies which focused on oral conditions of 
   palliative patients and published between years 2000 to 2017 were included. 
   RESULTS: Xerostomia, oral candidiasis and dysphagia were the three most common 
   oral conditions among palliative patients, followed by mucositis, orofacial pain, 
   taste change and ulceration. We also found social and functional impact of having 
   certain oral conditions among these patients. In terms of management, 
   complementary therapies such as acupuncture has been used but not well explored. 
   The lack of knowledge among healthcare providers also posed as a challenge in 
   treating oral conditions among palliative patients. CONCLUSIONS: This review is 
   first in its kind to systematically synthesize the published evidence regarding 
   the impact, management and challenges in managing oral conditions among 
   palliative patients. Although there is still lack of study investigating 
   palliative oral care among specific group of patients such as patients with 
   dementia, geriatric or pediatric advanced cancer patients, this review has 
   however provided baseline knowledge that may guide health care professionals in 
   palliative settings.
C1 Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam.
   Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam.
   Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam.
   Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam.jagjit.dhaliwal@ubd.edu.bn.
NR 0
TC 0
SN 1472-683
EI 
J9 BMC Oral Health
PD MAR 20
PY 2020
VL 20
IS 1
BP 79
EP 79
DI 10.1186/s12903-020-01075-w 
PG 0
WC Aged; Child; Humans; Mouth Diseases; etiology; Oral Health; Oral Ulcer; etiology; Palliative Care; methods; Terminally Ill; Xerostomia; etiology
UT PubMed:32188452
PM 32188452
DA 2020-03-20
ER

PT J
AU Ge, W
   Qu, Y
   Hou, T
   Zhang, J
   Li, Q
   Yang, L
   Cao, L
   Li, J
   Zhang, S
AF Ge, Wanbao
   Qu, Yuan
   Hou, Tingting
   Zhang, Jiayin
   Li, Qiuju
   Yang, Lili
   Cao, Lanqing
   Li, Jindong
   Zhang, Shanyong
TI Case report: Surgical treatment of a primary giant epithelioid 
SO Frontiers in oncology
LA English
DT Journal Article
DE epithelioid hemangioendothelioma; giant; total en-bloc spondylectomy; vascular neoplasm; vertebral lesion
AB BACKGROUND: Epithelioid hemangioendothelioma (EHE) is an extremely uncommon 
   malignant neoplasm that originates from vascular endothelial or pre-endothelial 
   cells. In this report, we present the case of patient who was diagnosed with a 
   primary giant EHE of the spine and underwent treatment with total en-bloc 
   spondylectomy (TES). CASE PRESENTATION: A 43-year-old male patient with a history 
   of he presented to our hospital with chronic and progressive back pain. Physical 
   examination revealed weakened sensation of acupuncture and touch on the left 
   costal arch, while relatively normal neurological functions were preserved. 
   Radiological examinations identified a giant destructive soft tissue lesion 
   occupying the T8 vertebral region, with moderate destruction of the pedicle and 
   lamina, as well as the 7(th) left rib. A preoperative biopsy of the 8th vertebra 
   resulted in a diagnosis of epithelioid hemangioendothelioma(EHE). Postoperative 
   immunohistochemical and pathological reports confirmed the presence of EHE in the 
   left ribs and T8 ribs. The patient underwent resection of the 7th left rib and 
   posterior pedicle screw fixation with 8 pairs of screws and a titanium mesh cage. 
   Subsequently, thoracic en bloc spondylectomy was performed on the T8 vertebra. 
   The patient did not receive radiation or chemotherapy following surgery. Over a 
   period of 3 years, the patient remained free of disease and relapse. CONCLUSION: 
   The use of transarterial embolization with spherical embolic agents (TES) has 
   been demonstrated to be a safe, effective, and reliable treatment option for 
   hepatic epithelioid hemangioendothelioma (EHE). Nevertheless, it is crucial to 
   conduct long-term follow-up of this patient in order to assess their clinical 
   outcome.
C1 Department of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, China.
   Department of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, China.
   Department of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, China.
   Department of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, China.
   Department of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, China.
   Department of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, China.
   Department of Pathology, Second Affiliated Hospital of Jilin University, Changchun, Jilin, China.
   Department of Thoracic Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, China.
   Department of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, China.
NR 0
TC 0
SN 2234-943
EI 2234-943
J9 Front Oncol
PD APR 15
PY 2023
VL 13
IS 
BP 1109643
EP 1109643
DI 10.3389/fonc.2023.1109643 
PG 0
UT PubMed:37056332
PM 37056332
DA 2023-04-15
ER

PT J
AU Ben-Arye, E
   Zohar, S
   Keshet, Y
   Gressel, O
   Samuels, N
   Eden, A
   Vagedes, J
   Kassem, S
AF Ben-Arye, Eran
   Zohar, Shaked
   Keshet, Yael
   Gressel, Orit
   Samuels, Noah
   Eden, Arieh
   Vagedes, Jan
   Kassem, Sameer
TI Sensing the lightness: a narrative analysis of an integrative medicine program 
SO Supportive care in cancer : official journal of the Multinational Association of 
LA English
DT Journal Article
DE Burnout; COVID-19; Integrative medicine; Narrative-based medicine; Pain; Palliative care
AB OBJECTIVES: The research addressing physical and emotional exhaustion among 
   healthcare providers (HCPs) in COVID-19 departments is limited. We examined the 
   impact of integrative medicine (IM) intervention for HCPs working in isolated 
   COVID-19 in-patient departments, addressing concerns and well-being. METHODS: 
   HCPs working in 3 isolated COVID-19 in-patient departments underwent 40-min IM 
   treatment sessions (including acupuncture, manual movement, and/or mind-body 
   modalities) provided by integrative oncology practitioners. The MYCAW (Measure 
   Yourself Concerns and Well-being) questionnaire examined HCP concerns and 
   free-text narratives following IM treatments. Data were qualitatively analyzed 
   using ATLAS.Ti software for systematic coding. RESULTS: A total of 181 HCPs 
   underwent 305 IM treatments. Narrative themes focused on physical symptoms 
   (primarily pain and fatigue) and emotional concerns, including perceived 
   communication barriers with patients, and reflections on well-being and insights 
   following IM treatments. HCPs reported feeling a sense of "relief" which was 
   likely related to the 3 main effects of the IM intervention: a sense of "being 
   cared for" and treated; experiencing emotional, sometimes spiritual effects of 
   the treatment; and the feeling of relaxation, combined with the relief of pain. 
   Qualitative analysis identified clusters of emotional and spiritual-related 
   keywords such as "calming," "release," "relaxation," and "disengagement" 
   following the first IM session (119 of 181 narratives, 65.7%). CONCLUSIONS: HCPs 
   working in isolated COVID-19 departments reported improved well-being and the 
   addressing of their concerns following IM treatment sessions provided during 
   their work shift. Further research is needed to explore the impact of IM on HCP 
   burnout and resilience in palliative care settings.
C1 Integrative Oncology Program, The Oncology Service, Lin, Carmel, and Zebulun Medical Centers, Clalit Health Services, 35 Rothschild St., Haifa, Israel.eranben@netvision.net.il.
   Ruth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of 
   Ruth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Department of Sociology, Western Galilee Academic College, Galilee, Israel.
   Integrative Oncology Program, The Oncology Service, Lin, Carmel, and Zebulun Medical Centers, Clalit Health Services, 35 Rothschild St., Haifa, Israel.
   Ruth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of 
   Center for Integrative Complementary Medicine, Shaarei Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
   Ruth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Depatment of Anesthesiology, Critical Care and Pain Medicine, Lady Davis Carmel 
   ARCIM Institute, Research Institute, Filderstadt, Germany.
   Department of Neonatology, University Hospital Tuebingen, University Tuebingen, 
   Ruth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
   Department of Internal Medicine, Lady Davis Carmel Medical Center, Haifa, Israel.
NR 0
TC 0
SN 1433-733
EI 0941-435
J9 Support Care Cancer
PD SEP 17
PY 2021
VL 30
IS 2
BP 1419
EP 1426
DI 10.1007/s00520-021-06546-6 
PG 7
WC COVID-19; Health Personnel; Humans; Integrative Medicine; Integrative Oncology; SARS-CoV-2
UT PubMed:34528124
PM 34528124
DA 2021-09-17
ER

PT J
AU Raybin, JL
   Montgomery, KE
   Skeens, M
   Janosy, N
   Mist, S
   Franklin, H
   Dieckmann, NF
   Hendricks-Ferguson, VL
   Jankowski, CM
AF Raybin, Jennifer L
   Montgomery, Kathleen E
   Skeens, Micah
   Janosy, Norah
   Mist, Scott
   Franklin, Heather
   Dieckmann, Nathan F
   Hendricks-Ferguson, Verna L
   Jankowski, Catherine M
TI Integrative and Complementary Interventions Result in Significant Positive Effect 
SO Research square
LA English
DT Journal Article
DE childhood cancer; complementary; creative arts; integrative; quality of life; symptoms
AB PURPOSE: Children with cancer report intractable symptoms and endorse using 
   complementary and integrative health interventions (CHI) without strong published 
   evidence. We conducted a prospective study of CHI in 100 participants at two 
   children's hospitals. The secondary aim was to estimate outcome effect sizes. 
   Here we report preliminary effect size estimates of CHI on quality of life (QOL) 
   and symptom burden in pediatric participants with cancer and other serious 
   illness. METHODS: We used standardized patient reported outcome (PRO) measures in 
   response to CHI sessions. Data were collected at baseline, pre/post CHI, and 
   monthly up to 6 months. Outcomes were QOL and symptom burden. RESULTS: 
   Participants (n=100) were aged 2-29 years (M=13.5, SD=5.6), 65% identified as 
   female, 23% were from underrepresented populations, 52% were receiving treatment 
   for cancer versus other serious illness. Participants completed 191 CHI sessions 
   with 811 PRO assessments. CHI included acupuncture (39%), aromatherapy (35%), 
   creative arts (20%), massage therapy (5%), and hypnosis (1%). Mixed-effects 
   models controlling for cancer diagnosis revealed improvement in anxiety, fatigue, 
   pain, sadness, and mood (Cohen's d effect sizes 0.20-1.45; all p<0.05). Creative 
   arts were associated with improvement in all symptoms except for nausea 
   (0.31-1.45; all p<0.03). QOL improved over time (b = 0.21; p<0.05) and was 
   clinically significant compared to standard clinical cut offs. CONCLUSION: 
   Patients (or proxy) reported improvement in QOL and symptom burden with CHI. The 
   positive effect size estimates support for the need for additional efficacy 
   studies of targeted CHI among children with serious illnesses including cancer, 
   especially creative arts interventions.
C1 University of Colorado College of Nursing and School of Medicine (Drs. Jankowski and Janosy)
   Saint Louis University School of Nursing (Dr. Hendricks-Ferguson);Oregon Health and Sciences University Schools of Nursing and Medicine (Drs.Raybin, Mist, Franklin, and Dieckmann)
   University of Wisconsin-Madison School ofNursing (Dr. Montgomery)
   College of Medicine, The Ohio State University.
   University of Colorado College of Nursing and School of Medicine (Drs. Jankowski and Janosy)
   Saint Louis University School of Nursing (Dr. Hendricks-Ferguson);Oregon Health and Sciences University Schools of Nursing and Medicine (Drs.Raybin, Mist, Franklin, and Dieckmann)
   University of Wisconsin-Madison School ofNursing (Dr. Montgomery)
   College of Medicine, The Ohio State University.
   University of Colorado College of Nursing and School of Medicine (Drs. Jankowski and Janosy)
   Saint Louis University School of Nursing (Dr. Hendricks-Ferguson);Oregon Health and Sciences University Schools of Nursing and Medicine (Drs.Raybin, Mist, Franklin, and Dieckmann)
   University of Wisconsin-Madison School ofNursing (Dr. Montgomery)
   College of Medicine, The Ohio State University.
   University of Colorado College of Nursing and School of Medicine (Drs. Jankowski and Janosy)
   Saint Louis University School of Nursing (Dr. Hendricks-Ferguson);Oregon Health and Sciences University Schools of Nursing and Medicine (Drs.Raybin, Mist, Franklin, and Dieckmann)
   University of Wisconsin-Madison School ofNursing (Dr. Montgomery)
   College of Medicine, The Ohio State University.
   University of Colorado College of Nursing and School of Medicine (Drs. Jankowski and Janosy)
   Saint Louis University School of Nursing (Dr. Hendricks-Ferguson);Oregon Health and Sciences University Schools of Nursing and Medicine (Drs.Raybin, Mist, Franklin, and Dieckmann)
   University of Wisconsin-Madison School ofNursing (Dr. Montgomery)
   College of Medicine, The Ohio State University.
   University of Colorado College of Nursing and School of Medicine (Drs. Jankowski and Janosy)
   Saint Louis University School of Nursing (Dr. Hendricks-Ferguson);Oregon Health and Sciences University Schools of Nursing and Medicine (Drs.Raybin, Mist, Franklin, and Dieckmann)
   University of Wisconsin-Madison School ofNursing (Dr. Montgomery)
   College of Medicine, The Ohio State University.
   University of Colorado College of Nursing and School of Medicine (Drs. Jankowski and Janosy)
   Saint Louis University School of Nursing (Dr. Hendricks-Ferguson);Oregon Health and Sciences University Schools of Nursing and Medicine (Drs.Raybin, Mist, Franklin, and Dieckmann)
   University of Wisconsin-Madison School ofNursing (Dr. Montgomery)
   College of Medicine, The Ohio State University.
   University of Colorado College of Nursing and School of Medicine (Drs. Jankowski and Janosy)
   Saint Louis University School of Nursing (Dr. Hendricks-Ferguson);Oregon Health and Sciences University Schools of Nursing and Medicine (Drs.Raybin, Mist, Franklin, and Dieckmann)
   University of Wisconsin-Madison School ofNursing (Dr. Montgomery)
   College of Medicine, The Ohio State University.
   University of Colorado College of Nursing and School of Medicine (Drs. Jankowski and Janosy)
   Saint Louis University School of Nursing (Dr. Hendricks-Ferguson);Oregon Health and Sciences University Schools of Nursing and Medicine (Drs.Raybin, Mist, Franklin, and Dieckmann)
   University of Wisconsin-Madison School ofNursing (Dr. Montgomery)
   College of Medicine, The Ohio State University.
NR 0
TC 0
SN 2693-501
EI 
J9 Res Sq
PD SEP 18
PY 2025
VL 0
IS 
BP 
EP 
DI 10.21203/rs.3.rs-7208100/v1 
PG 0
UT PubMed:40964042
PM 40964042
DA 2025-09-18
ER

PT J
AU Mohanty, S
   Panigrahi, MK
   Turuk, J
   Dhal, S
AF Mohanty, Srujana
   Panigrahi, Manas Kumar
   Turuk, Jyotirmayee
   Dhal, Sagarika
TI Liver Abscess due to Streptococcus constellatus in an Immunocompetent Adult: A 
SO Journal of the National Medical Association
LA English
DT Journal Article
DE Hepatic abscess; Liver abscess; Pyogenic liver abscess; Streptococcus constellatus
AB BACKGROUND: Pyogenic liver abscesses (PLAs) are an uncommon, but potentially life 
   threatening infection. We report a case of PLA due to Streptococcus constellatus, 
   a member of the Streptococcus anginosus group (SAG) bacteria, commonly found as 
   commensals of the oropharyngeal, gastrointestinal and genitourinary flora. CASE: 
   The patient, a 42-year-old man with no premorbidities, non-smoker and 
   non-alcoholic, presented to our hospital with high-grade fever associated with 
   chills and rigors and right upper quadrant pain of one month duration. Culture of 
   the ultrasound-guided liver aspirate yielded a pure growth of S. constellatus 
   subspecies constellatus identified by conventional biochemical tests. In a 
   standard antimicrobial disk-diffusion test, the isolate was susceptible to 
   cefepime, cefotaxime, ceftriaxone, vancomcyin, levofloxacin, clindamycin and 
   linezolid. Treatment with parenteral ceftriaxone alongwith appropriate surgical 
   management led to resolution of the abscess with no recurrence of infection at 
   three months follow-up. CONCLUSIONS: The pathogenic potential of SAG has 
   generally been disregarded because of the commensal nature of these 
   microorganisms; however, streptococci belonging to this group have been 
   increasingly reported as relevant pathogens in abscesses and blood cultures. An 
   underlying condition, such as diabetes, cirrhosis or cancer or some medical 
   manipulation, such as dental extraction, acupuncture, or hemorrhoidectomy is 
   associated with the majority of patients with SAG abscess. However, the present 
   case highlights the need to include S. constellatus and other members of the SAG 
   while investigating for etiology of PLA, even in immunocompetent adults.
C1 Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odisha, India. 
   Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odisha, India.
   Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odisha, India.
   Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odisha, India.
EM srujana_micro@yahoo.co.in
NR 0
TC 0
SN 
EI 0027-968
J9 J Natl Med Assoc
PD AUG 22
PY 2018
VL 110
IS 6
BP 591
EP 595
DI 10.1016/j.jnma.2018.03.006 
PG 4
WC Adult; Anti-Bacterial Agents; pharmacology; Ceftriaxone; pharmacology; Disk Diffusion Antimicrobial Tests; Humans; Immunocompetence; Liver Abscess; drug therapy; Male; Streptococcal Infections; complications; Streptococcus constellatus; drug effects
UT PubMed:30129495
PM 30129495
DA 2018-08-22
ER

PT J
AU Church, D
   Stapleton, P
   Vasudevan, A
   O'Keefe, T
AF Church, Dawson
   Stapleton, Peta
   Vasudevan, Anitha
   O'Keefe, Tom
TI Clinical EFT as an evidence-based practice for the treatment of psychological and 
SO Frontiers in psychology
LA English
DT Journal Article
DE PTSD; anxiety; depression; emotional freedom techniques (EFT); insomnia; obesity; pain; somatic symptoms
AB BACKGROUND: Since the turn of the century, Emotional Freedom Techniques (EFT) has 
   come into widespread use in medical and psychological treatment settings. It is 
   also used as self-help by tens of millions of people each year. Clinical EFT, the 
   manualized form of the method, has been validated as an "evidence-based" practice 
   using criteria published by the American Psychological Association (APA) Division 
   12 Task Force on Empirically Validated Therapies. Its three essential ingredients 
   are exposure, cognitive framing, and acupressure. OBJECTIVES: In 2013 we 
   published a paper defining Clinical EFT and reviewing published research. It has 
   been viewed or downloaded over 36,000 times, indicating widespread interest in 
   this treatment modality. Here we update our findings based on subsequently 
   published literature and propose directions for future research. METHOD: We 
   performed a systematic review of the literature to identify randomized controlled 
   trials (RCTs) and meta-analyses. Retrieval of 4,167 results resulted in the 
   identification of 56 RCTs (n = 2,013), 41 of which were published subsequent to 
   our earlier review, as well as eight meta-analyses. RESULTS: RCTs have found EFT 
   treatment to be effective for (a) psychological conditions such as anxiety, 
   depression, phobias, and posttraumatic stress disorder (PTSD); (b) physiological 
   issues such as pain, insomnia, and autoimmune conditions; (c) professional and 
   sports performance; and (d) biological markers of stress. Meta-analyses 
   evaluating the effect of EFT treatment have found it to be "moderate" to "large." 
   Successful independent replication studies have been carried out for anxiety, 
   depression, PTSD, phobias, sports performance, and cortisol levels. We outline 
   the next steps in EFT research. These include determining its impact on cancer, 
   heart disease, diabetes, and cognitive impairment; analysis of the large-scale 
   datasets made possible by mobile apps; and delivery through channels such as 
   virtual practitioner sessions, artificial intelligence agents, online courses, 
   apps, virtual reality platforms, and standardized group therapy. CONCLUSIONS: 
   Subsequent research has confirmed the conclusions of earlier studies. These find 
   Clinical EFT to be efficacious for a range of psychological and physiological 
   conditions. Comparatively few treatment sessions are required, treatment is 
   effective whether delivered in person or virtually, and symptom improvements 
   persist over time. Treatment is associated with measurable biological effects in 
   the dimensions of gene expression, brain synchrony, hormonal synthesis, and a 
   wide range of biomarkers. Clinical EFT is a stable and mature method with an 
   extensive evidence base. Its use in primary care settings as a safe, rapid, 
   reliable, and effective treatment for both psychological and medical diagnoses 
   continues to grow.
C1 National Institute for Integrative Healthcare, Petaluma, CA, United States.
   Department of Society and Design, Bond University, Gold Coast, QLD, Australia.
   National Institute for Integrative Healthcare, Petaluma, CA, United States.
   Department of Society and Design, Bond University, Gold Coast, QLD, Australia.
NR 0
TC 0
SN 1664-107
EI 1664-107
J9 Front Psychol
PD NOV 29
PY 2022
VL 13
IS 
BP 951451
EP 951451
DI 10.3389/fpsyg.2022.951451 
PG 0
UT PubMed:36438382
PM 36438382
DA 2022-11-29
ER

PT J
AU Ren, X
   Qu, YP
   Xia, T
   Tang, XF
AF Ren, Xu
   Qu, Yong-Ping
   Xia, Tian
   Tang, Xiu-Fen
TI Technical success, clinical efficacy, and safety of endoscopic minor papilla 
SO World journal of gastroenterology
LA English
DT Journal Article
DE Abdominal pain improvement; Endoscopic minor papilla intervention; Obstructive chronic pancreatitis; Pancreas division; Symptomatic pancreatic diseases
AB BACKGROUND: Endoscopic minor papilla intervention (EMPI) is an option for 
   diagnosing or treating symptomatic pancreatic diseases in cases with failed 
   pancreatic duct deep cannulation via the major papilla, pancreas divisum with 
   obstruction of the minor papilla, or an abnormal patulous orifice of the minor 
   papilla during endoscopic retrograde cholangiopancreatography (ERCP). However, 
   the relatively low patency and small opening of the minor papillae pose technical 
   challenges. AIM: To evaluate the technical success, clinical success, stone 
   clearance, and safety profile of EMPI for diagnosis and treatment of symptomatic 
   pancreatic diseases. METHODS: Patients diagnosed with symptomatic pancreatic 
   diseases and EMPI between February 1996 and February 2023 were included. The 
   primary outcomes were the initial technical success, defined as successful deep 
   cannulation via the minor papilla (DCMP; access of the guidewire to the upstream 
   pancreatic duct via the minor papilla) alone, overall technical success, defined 
   as successful DCMP alone and successful DCMP with additional needle-knife precut 
   minor papillotomy (NKPMP), and immediate clinical success, defined as > 50% 
   improvement in abdominal pain after therapeutic EMPI. Secondary outcomes included 
   long-term clinical success at 1, 3, and 7 years, pancreatic stone clearance, and 
   procedure-related early and late adverse events (AEs). RESULTS: Overall, 43 
   patients, 32 with obstructive chronic pancreatitis, 8 with pancreatic divisum, 
   and 3 with intraductal papillary mucinous neoplasm were included. The initial and 
   overall technical success rates were 74.4% (32/43) and 88.4% (38/43), 
   respectively. The immediate clinical success rate was 79.1% (34/43), and the 
   long-term clinical success rates at 1, 3, and 7 years were 74.7%, 55.3%, and 
   41.5%, respectively, among the 22 patients with a follow-up period of 57.5 
   (7-266) months. Complete and partial success of pancreatic stone clearance was 
   achieved in 53.9% (7/13) and 15.4% (2/13), respectively. Early AEs included 
   post-ERCP pancreatitis (PEP, n = 5) and self-limiting bleeding (n = 1); surgery 
   therapy was required for 1 case with severe PEP and conservative management for 
   the other 4 with mild PEP. Late AEs included minor papilla stricture (n = 1) 
   after endoscopic minor papillotomy and pancreatic duct stricture (n = 1) after 
   double pancreatic stent placement; no specific treatment was implemented for 
   these events. CONCLUSION: EMPI is feasible, effective, and safe for symptomatic 
   pancreatic diseases, in terms of the technical and clinical success, stone 
   clearance, and incidence and severity of AEs. NKPMP appears to enhance technical 
   success. However, potential risks of developing PEP and late AEs should be kept 
   in mind.
C1 Digestive Hospital of Heilongjiang Provincial Hospital, Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatmentof Pancreaticobiliary Diseases, Harbin 150001, Heilongjiang Province, China.hljxhy2001@126.com.
   Digestive Endoscopy Center of Heilongjiang Provincial Hospital, Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis andTreatment of Pancreaticobiliary Diseases, Harbin 150001, Heilongjiang Province,China.
   Digestive Hospital of Heilongjiang Provincial Hospital, Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatmentof Pancreaticobiliary Diseases, Harbin 150001, Heilongjiang Province, China.
   First Department of Gastroenterology, Digestive Hospital of Heilongjiang Provincial Hospital, Heilongjiang Provincial Clinical Medical Research Center forMinimally Invasive Diagnosis and Treatment of Pancreaticobiliary Diseases, Harbin150001, Heilongjiang Province, China.
NR 0
TC 0
SN 2219-284
EI 1007-932
J9 World J Gastroenterol
PD JUN 11
PY 2025
VL 31
IS 20
BP 100192
EP 100192
DI 10.3748/wjg.v31.i20.100192 
PG 0
WC Humans; Male; Female; Cholangiopancreatography, Endoscopic Retrograde; adverse effects; Middle Aged; Treatment Outcome; Pancreatic Ducts; surgery; Aged; Pancreatic Diseases; surgery; Sphincterotomy, Endoscopic; adverse effects; Adult; Retrospective Studies; Postoperative Complications; epidemiology
UT PubMed:40495942
PM 40495942
DA 2025-06-11
ER

PT J
AU Raybin, JL
   Montgomery, K
   Janosy, N
   Mist, S
   Franklin, H
   Dieckmann, NF
   Hendricks-Ferguson, VL
   Jankowski, CM
AF Raybin, Jennifer L
   Montgomery, Kathleen
   Janosy, Norah
   Mist, Scott
   Franklin, Heather
   Dieckmann, Nathan F
   Hendricks-Ferguson, Verna L
   Jankowski, Catherine M
TI Study of Complementary and Integrative Interventions in Pediatric Patients With 
SO Journal of pain and symptom management
LA English
DT Journal Article
DE Integrative; childhood cancer; complementary; quality of life; symptoms
AB CONTEXT: Pediatric patients report using complementary and integrative health 
   interventions (CHI) for symptom management. OBJECTIVE: Feasibility and initial 
   effect sizes of CHI with patients at two children's hospitals. METHODS: Using 
   convenience sampling at two academic centers and accepting the wide age range of 
   patients traditionally treated in children's hospitals, we examined feasibility 
   of CHI and outcomes of quality of life (QOL) and symptoms with validated surveys 
   and two physiologic measures. A priori feasibility thresholds were 90% accrual 
   rate and 60% completion of at least two surveys and one CHI session. RESULTS: 
   Over 18 months we accrued 100 participants (Site 1, n = 34; Site 2, n = 66) who 
   completed 811 assessments. Participants were aged 2-29 years (M = 13.5, SD = 
   5.6), 65% female, 23% from underrepresented populations, 52% with cancer versus 
   other serious illness. Accrual rate was 94%, completion rate was 87%, 
   acceptability was 96%. Ninety-nine participants received 191 total CHI sessions: 
   acupuncture (39%), aromatherapy (35%), creative arts (20%), massage therapy (5%) 
   and hypnosis (1%). After CHI heart rate decreased and symptom scores improved for 
   anxiety, fatigue, nausea, pain, and sadness (Cohen's d effect sizes 0.22-0.99). 
   Adjusted mixed-effects models suggested that the Faces Scale scores improved over 
   time (b = -0.19, P < 0.01). CONCLUSION: Prospective two-site data collection in 
   relationship to CHI exceeded feasibility thresholds and was acceptable. When 
   given the choice, CHI were popular and may have contributed to improved QOL 
   immediately and longitudinally. These preliminary findings support further study 
   of CHI for targeted symptoms in distinct populations with rigor.
C1 Oregon Health and Sciences University Schools of Nursing and Medicine (J.L.R., S.M., H.F., N.F.D), Portland, Oregon. 
   University of Wisconsin-Madison School of Nursing (K.M.), Madison, Wisconsin.
   University of Colorado College of Nursing and School of Medicine (C.M.J.), Auroroa, Colorado.
   Oregon Health and Sciences University Schools of Nursing and Medicine (J.L.R., S.M., H.F., N.F.D), Portland, Oregon.
   Oregon Health and Sciences University Schools of Nursing and Medicine (J.L.R., S.M., H.F., N.F.D), Portland, Oregon.
   Oregon Health and Sciences University Schools of Nursing and Medicine (J.L.R., S.M., H.F., N.F.D), Portland, Oregon.
   Saint Louis University School of Nursing (V.L.H.F.), St Louis, Missouri.
   University of Colorado College of Nursing and School of Medicine (C.M.J.), Auroroa, Colorado.
EM raybin@ohsu.edu
NR 0
TC 0
SN 1873-651
EI 0885-392
J9 J Pain Symptom Manage
PD FEB 20
PY 2025
VL 69
IS 5
BP 515
EP 526
DI 10.1016/j.jpainsymman.2025.02.013 
PG 11
WC Humans; Female; Child; Male; Adolescent; Complementary Therapies; methods; Child, Preschool; Quality of Life; Young Adult; Adult; Feasibility Studies; Integrative Medicine; Treatment Outcome; Critical Illness; therapy
UT PubMed:39971211
PM 39971211
DA 2025-02-20
ER

PT J
AU Liu, Z
   Qiao, F
   Liu, D
   Kong, X
   Liu, K
   Gu, H
   Zhang, Y
   Meng, Q
   Cheng, L
AF Liu, Zhenchuan
   Qiao, Fei
   Liu, Dejian
   Kong, Xiangzhen
   Liu, Kaiwen
   Gu, Hanwen
   Zhang, Yuanqiang
   Meng, Qunbo
   Cheng, Lei
TI Periplocin targets LRP4 to regulate metabolic homeostasis and anti-inflammation 
SO Phytomedicine : international journal of phytotherapy and phytopharmacology
LA English
DT Journal Article
DE Intervertebral disc degeneration; LRP4; Molecular docking; Periplocin; TNF-α; inflammation
AB BACKGROUND: Intervertebral disc degeneration (IVDD) is characterized by 
   deteriorating intervertebral discs, leading primarily to low back pain and leg 
   pain. Most current treatments for IVDD primarily address symptoms without 
   targeting the underlying degenerative process. Moreover, tumor necrosis factor-α 
   (TNF-α)-mediated inflammation and degradation of the nucleus pulposus (NP) 
   extracellular matrix (ECM) influence this pathological process. Periplocin, a 
   cardiotonic steroid extracted from periplocin forrestii, has demonstrated a wide 
   range of medical benefits, including cardiotonic, anticancer, anti-inflammatory, 
   and wound healing properties. Nevertheless, the effects of periplocin on IVDD 
   remain unexplored. OBJECTIVE: Our study explores the mechanism of action and the 
   potential target of periplocin in mitigating IVDD pathology. METHODS: Rat models 
   of IVDD were established using acupuncture, and the affected discs underwent 
   analysis via Safranin O-Fast Green (S-O) and Hematoxylin and Eosin (H&E) 
   staining. Nucleus pulposus cells (NPCs) were harvested from IVDD patients and 
   experimental animals for examination. A variety of techniques, including Western 
   blot analysis, quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) assay, 
   immunofluorescence staining, Alcian Blue staining and Immunohistochemistry (IHC) 
   staining, were utilized to evaluate inflammation-related proteins, mRNAs and the 
   ECM metabolism. In order to ascertain the potential protein targets of 
   periplocin, the binding site of periplocin to LRP4 was elucidated through the 
   utilisation of molecular docking experiments. Subsequently, the expression of 
   low-density lipoprotein receptor-related protein 4 (LRP4) in NPCs was modified 
   through the use of small interfering RNA (siRNA) knockdown and overexpression 
   vectors, which were employed for the purposes of target validation. RESULTS: We 
   conclude from the present study that periplocin alleviates the progression of 
   IVDD mainly through the following aspects: periplocin inhibits TNF-α-induced 
   inflammatory; periplocin reduces matrix degradation; periplocin promotes matrix 
   anabolism and regulates metabolic homeostasis. Moreover, the present study 
   demonstrates that LRP4 is involved as a potential target in the multiple pathways 
   mentioned above to protect the intervertebral disc. CONCLUSION: Our research 
   suggests that periplocin may serve as a promising treatment for IVDD, offering 
   anti-inflammatory benefits, preventing ECM degradation, and promoting ECM 
   anabolism.
C1 Department of Orthopedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
   Department of Orthopedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China
   Department of PediatricOrthopedic, Dalian Women and Children's Medical Center(group), Dalian, Liaoning,116012, China.
   Department of Orthopedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
   Department of Orthopedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
   Department of Orthopedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
   Department of Orthopedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
   Department of Orthopedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. 
   Department of Orthopedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. 
   Department of Orthopedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. 
EM henglei@email.sdu.edu.cn
NR 0
TC 0
SN 1618-095
EI 
J9 Phytomedicine
PD MAY 29
PY 2025
VL 143
IS 
BP 156885
EP 156885
DI 10.1016/j.phymed.2025.156885 
PG 0
WC Animals; Intervertebral Disc Degeneration; drug therapy; Homeostasis; drug effects; Male; Humans; Rats; Rats, Sprague-Dawley; Anti-Inflammatory Agents; pharmacology; Nucleus Pulposus; drug effects; Molecular Docking Simulation; Tumor Necrosis Factor-alpha; metabolism; Female; Inflammation; drug therapy; Disease Models, Animal; Middle Aged
UT PubMed:40440911
PM 40440911
DA 2025-05-29
ER

PT J
AU Tong, YY
   He, W
   Yang, C
   Zhang, B
   Du, J
   Zhao, YK
AF Tong, Yuan-yuan
   He, Wei
   Yang, Ce
   Zhang, Bin
   Du, Jian
   Zhao, Ying-kai
TI [Analysis of the status and trends of international research in complementary and 
SO Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
LA chi
DT Journal Article
AB OBJECTIVE: To have an overview of the international status and trends of 
   complementary and alternative medicine (CAM) research, and to provide a reference 
   tool for researchers. METHODS: Taking PubMed as the retrieval source, and using 
   the methods of informetrics analysis (such as Price's Law of exponential growth, 
   Bradford's law) and text mining (association rules), CAM articles published 
   between 1998 and 2010 were statistically analyzed on, for example, document 
   growth, core journals and active fields. RESULTS: The literature about CAM 
   research published between 1998 and 2010 showed the trends of exponential growth 
   in quantity. Regional distribution of literature was extensive; China and the 
   United States were the two major sources. Forty-five periodicals were selected 
   from core journals based on Bradford's law of scattering; some colleges and 
   schools constituted the main force in research on CAM. The active fields mainly 
   focus on (1) acupuncture research; (2) phytotherapy research; (3) mind-body 
   medicine; (4) integrative medicine; (5) treatment and prevention of key 
   conditions such as neoplasm, low back pain, mental disorder and chronic diseases. 
   CONCLUSION: (1) CAM research has attracted attention from all over the world, and 
   it will enter a rapid development stage in the future; (2) Treatment and 
   prevention of neoplasm is a consistent key subject and research field in global 
   CAM research; (3) Elucidating clinical effects, mechanisms of action, and safety 
   of major CAM methods constitutes the most important task; (4) Studies on 
   mind-body medicine have increased in recent years, so clinical evaluation and 
   studies of mind-body interventions should be supported; (5) Research has been 
   done increasingly for identification of the clinical effects and biological 
   mechanisms of CAM interventions in symptom management; (6) Research on CAM will 
   stimulate the development of modern medical model; (7) TCM is an active 
   discipline of CAM, and China will thus face increasing challenges.
C1 Intelligence Center on Traditional Chinese Medicine, Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing100700, China. tongyy@mail.cintcm.ac.cn.
NR 0
TC 0
SN 
EI 1672-197
J9 Zhong Xi Yi Jie He Xue Bao
PD JUN 19
PY 2012
VL 10
IS 6
BP 597
EP 603
DI 10.3736/jcim20120601 
PG 6
WC Bibliometrics; Biomedical Research; trends; Complementary Therapies; Integrative Medicine
UT PubMed:22704406
PM 22704406
DA 2012-06-19
ER

PT J
AU Zhang, YP
   Hu, RX
   Han, M
   Lai, BY
   Liang, SB
   Chen, BJ
   Robinson, N
   Chen, K
   Liu, JP
AF Zhang, Ya-Peng
   Hu, Rui-Xue
   Han, Mei
   Lai, Bao-Yong
   Liang, Shi-Bing
   Chen, Bing-Jie
   Robinson, Nicola
   Chen, Kevin
   Liu, Jian-Ping
TI Evidence Base of Clinical Studies on Qi Gong: A Bibliometric Analysis.
SO Complementary therapies in medicine
LA English
DT Review
DE Ba Duan Jin; Bibliometric Analysis; Clinical Study; Non-drug therapy; Qigong
AB OBJECTIVE: This bibliometric study aimed to systematically and comprehensively 
   summarize the volume, breadth and evidence for clinical research on Qigong. And 
   this bibliometric analysis also can provide the evidence of this field. DESIGN: 
   Bibliometric analysis. METHODS: All types of primary and secondary studies on 
   humans were included: systematic reviews, randomized clinical trials, 
   non-randomized controlled clinical studies, case series and case reports. Chinese 
   Biomedical Literature Database, China National Knowledge Infrastructure, Chinese 
   Scientific Journal Database, Chinese Academic Conference Papers Database and 
   Chinese Dissertation Database, PubMed and the Cochrane Library were searched from 
   the date of inception to December 10, 2018. Bibliometric information, such as 
   publication information, disease/condition, Qigong intervention and research 
   results were extracted and analyzed. RESULTS: A total of 886 clinical studies 
   were identified: including 47 systematic reviews, 705 randomized clinical trials, 
   116 non-randomized controlled clinical studies, 12 case series and 6 case 
   reports. The studies were conducted in 14 countries. The top 15 
   diseases/conditions studied were: diabetes, chronic obstructive pulmonary 
   disease, hypertension, stroke, cervical spondylosis, lumbar disc herniation, 
   insomnia, knee osteoarthritis, low back pain, and osteoporosis, Coronary heart 
   disease, breast cancer, periarthritis of shoulder, depression, metabolic 
   syndrome. Of the various Qigong exercises reported in these 886 clinical studies, 
   Ba Duan Jin was the most frequently researched in 492 (55.5%) studies, followed 
   by Health Qigong 107 (12.1%), Dao Yin Shu 85 (9.6%), Wu Qin Xi 67 (7.6%) and Yi 
   Jin Jing 66 (7.4%). The most frequently used comparisons in randomized trials 
   were maintaining normal way of life unchanged 149 (18.1%), the remaining controls 
   included conventional treatment, mainly western medicine, Chinese herbal 
   medicine, acupuncture, health education, psychological therapy, Yoga, Tai Chi and 
   other non-drug therapy. The most frequently reported outcomes were physical 
   function, quality of life, symptoms, pain and mental health indicators. 
   Beneficial results from practicing Qigong were reported in 97% of studies. 
   CONCLUSIONS: Qigong research publications have been increasing gradually. Reports 
   on study types, participants, Qigong Intervention, and outcomes are diverse and 
   inconsistent. There is an urgent need to develop a set of reporting standards for 
   various interventions of Qigong. Further trials of high methodological quality 
   with sufficient sample size and real world studies are needed to verify the 
   effects of Qigong in health and disease management.
C1 Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China
   Institute of Integrated Traditional ChineseMedicine and Western Medicine, Guangzhou Medical University, Guangzhou, China.
   Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China
   Center of Evidence Based Traditional ChineseMedicine, Institute of Basic Research in Clinical Medicine, China Academy ofChinese Medical Sciences, China
   Institute of Integrated Traditional ChineseMedicine and Western Medicine, Guangzhou Medical University, Guangzhou, China.
   Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China
   Institute of Integrated Traditional ChineseMedicine and Western Medicine, Guangzhou Medical University, Guangzhou, China.
   The Third Affiliated Hospital of Beijing Universality of Chinese Medicine, Beijing 100029, China
   Institute of Integrated Traditional Chinese Medicine andWestern Medicine, Guangzhou Medical University, Guangzhou, China. Electronicaddress: by_lai@126.com.
   Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China
   College of Basic Medical Sciences, ShanxiUniversity of Traditional Chinese Medicine, Taiyuan, 030000, China
   Institute ofIntegrated Traditional Chinese Medicine and Western Medicine, Guangzhou MedicalUniversity, Guangzhou, China. 
   College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China
   Institute of Integrated Traditional Chinese Medicine andWestern Medicine, Guangzhou Medical University, Guangzhou, China. Electronicaddress: tian8388@163.com.
   Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China
   School of Health and Social Care, London SouthBank University, London, SE1 0AA, UK
   Institute of Integrated Traditional ChineseMedicine and Western Medicine, Guangzhou Medical University, Guangzhou, China.
   University of Maryland School of Medicine, Center for Integrative Medicine, United States
   ShenZhen University, Faculty of Physical Education, China;Institute of Integrated Traditional Chinese Medicine and Western Medicine,Guangzhou Medical University, Guangzhou, China. 
   Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China
   Institute of Integrated Traditional ChineseMedicine and Western Medicine, Guangzhou Medical University, Guangzhou, China.
EM Liujp@bucm.edu.cn
NR 0
TC 0
SN 1873-696
EI 
J9 Complement Ther Med
PD MAY 24
PY 2020
VL 50
IS 
BP 102392
EP 102392
DI 10.1016/j.ctim.2020.102392 
PG 0
WC Bibliometrics; Evidence-Based Medicine; Humans; Periodicals as Topic; Qigong
UT PubMed:32444061
PM 32444061
DA 2020-05-24
ER

PT J
AU Dyer, NL
   Surdam, J
   Srinivasan, R
   Agarwal, A
   Dusek, JA
AF Dyer, Natalie L
   Surdam, Jessica
   Srinivasan, Roshini
   Agarwal, Ankita
   Dusek, Jeffery A
TI The Impact of Individualized Complementary and Integrative Health Interventions 
SO Journal of integrative and complementary medicine
LA English
DT Journal Article
DE cancer; complementary and integrative health; integrative medicine; pain; practice-based research; quality of life; systematic review; well-being
AB Background: The goal of this systematic review was to evaluate the impact of 
   individualized complementary and integrative health (CIH) interventions on 
   quality-of-life outcomes as collected in CIH outpatient clinics. Methods: A 
   systematic review was conducted using PubMed, OVID, Cochrane, Web of Science, 
   Scopus, and Embase through December 2020. Inclusion criteria were as follows: 
   individualized CIH treatment, longitudinal effectiveness design, patient-reported 
   outcomes, outpatient CIH clinic setting, participants aged ≥18 years, sample size 
   of ≥25, and English full text. The study was listed in the PROSPERO database 
   (CRD42020159193), and PRISMA guidelines were used. The variables extracted from 
   articles focused on study details/demographics, CIH intervention characteristics, 
   and outcome characteristics. Results: The literature search yielded 3316 records 
   with 264 assessed for full-text review. Of these, 19 studies (including ∼14,002 
   patients) were specific to quality of life (or well-being) as a main outcome. 
   Most studies included were multidisciplinary studies (n = 12), followed by 
   acupuncture (n = 4), chiropractic (n = 3), and massage or reflexology (n = 1). 
   The short-form group of questionnaires (SF-12, SF-36, SF-8) were the most used 
   quality-of-life/well-being questionnaire, comprising 37% of studies (n = 7), and 
   the Patient Reported Outcomes Measurement Information System (PROMIS) measures 
   comprised 21% (n = 4). Both questionnaires are normed to U.S. population, 
   allowing for comparison. The average improvement across the comparable SF and 
   PROMIS measures for Physical Health was 6% (range 2%-20%) and for Mental Health 
   was 5% (range 1%-11%), demonstrating clinical significance. Improvements in the 
   observational studies are comparable to improvements reported from randomized 
   controlled trials. Conclusions: Results from this systematic review indicate that 
   CIH therapies largely have positive effects on health-related quality of life and 
   well-being for various patient populations seen in CIH clinical settings. Direct 
   comparisons across studies were limited due to the variability in study design 
   and incomplete reporting in some of the publications. Suggestions for improving 
   the design and reporting for future practice-based research are provided.
C1 Connor Whole Health, University Hospitals, Cleveland, OH, USA.
   Connor Whole Health, University Hospitals, Cleveland, OH, USA.
   Duke University School of Medicine, Durham, NC, USA.
   Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA.
   Connor Whole Health, University Hospitals, Cleveland, OH, USA.
   Department of Family Medicine and Community Health, Case Western Reserve 
NR 0
TC 0
SN 2768-361
EI 2768-360
J9 J Integr Complement Med
PD JUL 15
PY 2022
VL 28
IS 8
BP 618
EP 640
DI 10.1089/jicm.2021.0413 
PG 22
WC Adolescent; Adult; Complementary Therapies; Humans; Massage; Mental Health; Patient Reported Outcome Measures; Quality of Life
UT PubMed:35834609
PM 35834609
DA 2022-07-15
ER

PT J
AU Turawa, EB
   Musekiwa, A
   Rohwer, AC
AF Turawa, Eunice B
   Musekiwa, Alfred
   Rohwer, Anke C
TI Interventions for preventing postpartum constipation.
SO The Cochrane database of systematic reviews
LA English
DT Journal Article
AB BACKGROUND: Postpartum constipation, with symptoms, such as pain or discomfort, 
   straining, and hard stool, is a common condition affecting mothers. Haemorrhoids, 
   pain at the episiotomy site, effects of pregnancy hormones, and haematinics used 
   in pregnancy can increase the risk of postpartum constipation. Eating a 
   high-fibre diet and increasing fluid intake are usually encouraged. Although 
   laxatives are commonly used in relieving constipation, the effectiveness and 
   safety of available interventions for preventing postpartum constipation should 
   be ascertained. This is an update of a review first published in 2015. 
   OBJECTIVES: To evaluate the effectiveness and safety of interventions for 
   preventing postpartum constipation. SEARCH METHODS: We searched Cochrane 
   Pregnancy and Childbirth's Trials Register, and two trials registers 
   ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform 
   (ICTRP) (7 October 2019), and screened reference lists of retrieved trials. 
   SELECTION CRITERIA: We considered all randomised controlled trials (RCTs) 
   comparing any intervention for preventing postpartum constipation versus another 
   intervention, placebo, or no intervention in postpartum women. Interventions 
   could include pharmacological (e.g. laxatives) and non-pharmacological 
   interventions (e.g. acupuncture, educational and behavioural interventions). 
   Quasi-randomised trials and cluster-RCTs were eligible for inclusion; none were 
   identified. Trials using a cross-over design were not eligible. DATA COLLECTION 
   AND ANALYSIS: Two review authors independently screened the results of the search 
   to select potentially relevant trials, extracted data, assessed risk of bias, and 
   the certainty of the evidence, using the GRADE approach. We did not pool results 
   in a meta-analysis, but reported them per study. MAIN RESULTS: We included five 
   trials (1208 postpartum mothers); three RCTs and two quasi-RCTs. Four trials 
   compared a laxative with placebo; one compared a laxative plus a bulking agent 
   versus the same laxative alone, in women who underwent surgical repair of third 
   degree perineal tears. Trials were poorly reported, and four of the five trials 
   were published over 40 years ago. We judged the risk of bias to be unclear for 
   most domains. Overall, we found a high risk of selection and attrition bias. 
   Laxative versus placebo We included four trials in this comparison. Two of the 
   trials examined the effects of laxatives that are no longer used; one has been 
   found to have carcinogenic properties (Danthron), and the other is not 
   recommended for lactating women (Bisoxatin acetate); therefore, we did not 
   include their results in our main findings. None of the trials included in this 
   comparison assessed our primary outcomes: pain or straining on defecation, 
   incidence of postpartum constipation, or quality of life; or many of our 
   secondary outcomes. A laxative (senna) may increase the number of women having 
   their first bowel movement within 24 hours after delivery (risk ratio (RR) 2.90, 
   95% confidence interval (CI) 2.24 to 3.75; 1 trial, 471 women; low-certainty 
   evidence); may have little or no effect on the number of women having their first 
   bowel movement on day one after delivery (RR 0.94, 95% CI 0.72 to 1.22; 1 trial, 
   471 women; very low-certainty evidence); may reduce the number of women having 
   their first bowel movement on day two (RR 0.23, 95% CI 0.11 to 0.45; 1 trial, 471 
   women; low-certainty evidence); and day three (RR 0.05, 95% CI 0.00 to 0.89; 1 
   trial, 471 women; low-certainty evidence); and may have little or no effect on 
   the number of women having their first bowel movement on day four after delivery 
   (RR 0.22, 95% CI 0.03 to 1.87; 1 trial, 471 women; very low-certainty evidence), 
   but some of the evidence is very uncertain. Adverse effects were poorly reported. 
   Low-certainty evidence suggests that the laxative (senna) may increase the number 
   of women experiencing abdominal cramps (RR 4.23, 95% CI 1.75 to 10.19; 1 trial, 
   471 women). Very low-certainty evidence suggests that laxatives taken by the 
   mother may have little or no effect on loose stools in the baby (RR 0.62, 95% CI 
   0.16 to 2.41; 1 trial, 281 babies); or diarrhoea (RR 2.46, 95% CI 0.23 to 26.82; 
   1 trial, 281 babies). Laxative plus bulking agent versus laxative only Very 
   low-certainty evidence from one trial (147 women) suggests no evidence of a 
   difference between these two groups of women who underwent surgical repair of 
   third degree perineal tears; only median and range data were reported. The trial 
   also reported no evidence of a difference in the incidence of postpartum 
   constipation (data not reported), but did not report on quality of life. Time to 
   first bowel movement was reported as a median (range); very low-certainty 
   evidence suggests little or no difference between the two groups. A laxative plus 
   bulking agent may increase the number of women having any episode of faecal 
   incontinence during the first 10 days postpartum (RR 1.81, 95% CI 1.01 to 3.23; 1 
   trial, 147 women; very low-certainty evidence). The trial did not report on 
   adverse effects of the intervention on babies, or many of our secondary outcomes. 
   AUTHORS' CONCLUSIONS: There is insufficient evidence to make general conclusions 
   about the effectiveness and safety of laxatives for preventing postpartum 
   constipation. The evidence in this review was assessed as low to very 
   low-certainty evidence, with downgrading decisions based on limitations in study 
   design, indirectness and imprecision. We did not identify any trials assessing 
   educational or behavioural interventions. We identified four trials that examined 
   laxatives versus placebo, and one that examined laxatives versus laxatives plus 
   stool bulking agents. Further, rigorous trials are needed to assess the 
   effectiveness and safety of laxatives during the postpartum period for preventing 
   constipation. Trials should assess educational and behavioural interventions, and 
   positions that enhance defecation. They should report on the primary outcomes 
   from this review: pain or straining on defecation, incidence of postpartum 
   constipation, quality of life, time to first bowel movement after delivery, and 
   adverse effects caused by the intervention, such as: nausea or vomiting, pain, 
   and flatus.
C1 Division of Health Systems and Public Health, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town,South Africa.
   South African Medical Research Council, Burden of Disease Research Unit, Cape 
   Centre for Evidence-based Health Care, Division of Epidemiology and Biostatistics, Faculty of Medicine and Health Sciences, Stellenbosch University,Cape Town, South Africa.
   Centre for Evidence-based Health Care, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
NR 0
TC 0
SN 1469-493
EI 
J9 Cochrane Database Syst Rev
PD AUG 8
PY 2020
VL 8
IS 8
BP CD011625
EP CD011625
DI 10.1002/14651858.CD011625.pub3 
PG 1
WC Adult; Constipation; prevention & control; Defecation; Dietary Fiber; adverse effects; Female; Humans; Laxatives; adverse effects; Perineum; injuries; Postpartum Period; Puerperal Disorders; prevention & control; Randomized Controlled Trials as Topic; Time Factors
UT PubMed:32761813
PM 32761813
DA 2020-08-08
ER

